Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRF-LPRELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFN----LKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVL--QGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSF----PTHLSISADCQDLLKRLLEPDMILRPSIEEVSWHPWLAST 4BDE Chain:A ((14-284)) -----LRDEYIMSKTL------EVKLAFERKTCKKVAIKIISK---------ALNVETEIEILKKLNHPCIIKIKNFFDAEDYYI--VLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL--T--SLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDE

General information: TITO was launched using: RESULT: Template: 4BDE.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -135541 for 1722 contacts (-78.7/contact) + 2D Compatibility (PS) -25537 + (NN) -11126 + (LL) 1108 1D Compatibility (HY) -20400 + (ID) 4750 Total energy: -196246.0 ( -113.96 by residue) QMean score : 0.422

(partial model without unconserved sides chains): PDB file : Tito_4BDE.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4BDE-query.scw PDB file : Tito_Scwrl_4BDE.pdb: