Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDGVGLAAPQIGILKRAAVV--EIGDDRGR-IDLVNPEILEKSGE-QTGIEGCLSFPNVYGDVTRADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG 4DR8 Chain:C ((28-179)) ------------VLRQPAKRVSRIDDELRQTIRQMLQTMYSADGIGLAAPQVGINKQLIVIDLELEDEQAPPLVLINPKIERTAGDLEQCQEGCLSIPGVYLDVERPEIVEVSYKDENGRPQRLVADGLLARCIQHEMDHLNGVLFVDRVENRLELNEALDKKG

General information: TITO was launched using: RESULT: Template: 4DR8.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain C - contact count / total energy / energy per contact / energy per residue : 644 -61361 -95.28 -414.60 target 2D structure prediction score : 0.53 Monomeric hydrophicity matching model chain C : 0.81 3D Compatibility (PKB) : -95.28 2D Compatibility (Sec. Struct. Predict.) : 0.53 1D Compatibility (Hydrophobicity) : 0.81 QMean score : 0.438

(partial model without unconserved sides chains): PDB file : Tito_4DR8.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4DR8-query.scw PDB file : Tito_Scwrl_4DR8.pdb: