Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMGRKGDPYATDSLLGLLYGD---------------------------------------------------QSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTGAQAGFLTNDQHTNAKII-----EMKPERLFSVLANHDAVVVAGFQGATE-KGDTTTIGRGGSDTSAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISPRAVEIAMQAKVPIRVRSTYSNDK-GTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKVPAKIGQ--Y--NVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQ---RI----LMDM-GYD-PMVTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSAD--SHTTIWVLVHEADMVPAVNALHEVFELSK 2CDQ Chain:A ((27-485)) -ITCVMKFGGSSVASAERMKEVADLILTFPE-E-SPVIVLSAM-----GKTTNNLLLAGEKAVSCGVSNASEIEELSIIKELHIRTVKELNIDPSVILTYLEELEQLLKGIAMMKELTLRTRDYLVSFGECLSTRIFAAYLNTIGVKARQYDAFEIGFITTDDFTNGDILEATYPAVAKRLYDDWMHDPAVPIVTGFLGKGWKTGAVTTLGRGGSDLTATTIGKALGLKEIQVWKDVDGVLTCDPTIYKRATPVPYLTFDEAAELAYFGAQVLHPQSMRPAREGEIPVRVKNSYNPKAPGTIITKTRDM------TKSILTSIVLKRNVTMLDIASTRMLGQVGFLA--KVFSIFEELGISVDVVATSEVSISLTLDPSKLWSRELIQQELDHVVEELEKIAVVNLLKGRAIISLIGN-VQHSSLILERAFHVLYTKGVNVQMISQGASKVNISFIVNEAEAEGCVQALHKSFFES-

General information: TITO was launched using: RESULT: Template: 2CDQ.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2135 -246848 -115.62 -639.50 target 2D structure prediction score : 0.68 Monomeric hydrophicity matching model chain A : 0.71 3D Compatibility (PKB) : -115.62 2D Compatibility (Sec. Struct. Predict.) : 0.68 1D Compatibility (Hydrophobicity) : 0.71 QMean score : 0.438

(partial model without unconserved sides chains): PDB file : Tito_2CDQ.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2CDQ-query.scw PDB file : Tito_Scwrl_2CDQ.pdb: