Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP--RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 2W05 Chain:A ((4-287)) -----FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR------------STAIREISLLKELN---HPNIVKLLDVIHT-----ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGL------------EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP

General information: TITO was launched using: RESULT: Template: 2W05.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -172845 for 2003 contacts (-86.3/contact) + 2D Compatibility (PS) -27884 + (NN) -17587 + (LL) 972 1D Compatibility (HY) -30800 + (ID) 6450 Total energy: -254594.0 ( -127.11 by residue) QMean score : 0.533

(partial model without unconserved sides chains): PDB file : Tito_2W05.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2W05-query.scw PDB file : Tito_Scwrl_2W05.pdb: