Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MLTEQPNWLMQRAQL-TPERIALIYEDQ--TVTFAELFAASKRMAEQLAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGS--------GFLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDA-TATLMYTSGTTGKPKG--VQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSA-LFKSVIYGMTVVLHQRFSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCP-----ESIRCILLGGGPAPLPLLEECREKGFP--VFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDG----QVCEPYEHGEIMVKGPN-VMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGENIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLV--LHKPVSAGELTDYCK-ERLAKYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL 2QVZ Chain:X ((5-498)) ------NEMLRRAATRAPDHCALAVPARGLRLTHAELRARVEAVAARLHADGLRPQQRVAVVAPNSADVVIAILALHRLGAVPALLNPRLKSAE-LAELIKRGEMTAAVIAV--QVADAIFQSGSGARIIFLGDLVRDGEPYSYGPPIEDPQREPAQPAFIFYTS---GLPKAAIIPQRAAESRVLFMSTQVGLRHGRHNVVLGLMPLYHVVGFFAVLVAALALDGTYVVVEEFRPVDALQLVQQEQVTSLFATPTHLDALAAAAAHAGSSLKLDSLRHVTFAGATMPDAVLETVHQH-LPGEKVNAYGTTEAMNSLYMRQP-----KTGTEMAPGFFSEVRIVRIGGGVDEIVANGEEGELIVAASDSAFVGYLNQPQATAEKLQDGWYRTSDVAVWTPEGTVRILGRVDDMIISGGENIHPSEIERVLGTAPGVTEVVVIGLADQRWGQSVTACVVPRLGETLSADALDTFCRSSELADFKRPKRYFILDQLPKNALNKVLRRQL---------

General information: TITO was launched using: RESULT: Template: 2QVZ.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain X - contact count / total energy / energy per contact / energy per residue : 2649 -14830 -5.60 -32.31 target 2D structure prediction score : 0.54 Monomeric hydrophicity matching model chain X : 0.76 3D Compatibility (PKB) : -5.60 2D Compatibility (Sec. Struct. Predict.) : 0.54 1D Compatibility (Hydrophobicity) : 0.76 QMean score : 0.363

(partial model without unconserved sides chains): PDB file : Tito_2QVZ.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2QVZ-query.scw PDB file : Tito_Scwrl_2QVZ.pdb: