Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRF-LPRELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFN----LKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVL--QGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSF----PTHLSISADCQDLLKRLLEPDMILRPSIEEVSWHPWLAST 2XM9 Chain:A ((14-284)) -----LRDEYIMSKTLGS---GEVKLAFERKTCKKVAIKIISK--------PALNVETEIEILKKLNHPCIIKIKNFFDAEDYYI--VLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGET--SLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDE

General information: TITO was launched using: RESULT: Template: 2XM9.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -127441 for 1782 contacts (-71.5/contact) + 2D Compatibility (PS) -26387 + (NN) -12838 + (LL) 1160 1D Compatibility (HY) -20400 + (ID) 4800 Total energy: -190706.0 ( -107.02 by residue) QMean score : 0.451

(partial model without unconserved sides chains): PDB file : Tito_2XM9.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2XM9-query.scw PDB file : Tito_Scwrl_2XM9.pdb: