Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRF-LPRELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFN----LKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVL--QGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSF----PTHLSISADCQDLLKRLLEPDMILRPSIEEVSWHPWLAST 2WTD Chain:A ((14-284)) -----LRDEYIMSKTLGS----EVKLAFERKTCKKVAIKIISK--------PALNVETEIEILKKLNHPCIIKIKNFFDAEDYYI--VLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL--T--SLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDE

General information: TITO was launched using: RESULT: Template: 2WTD.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -137988 for 1740 contacts (-79.3/contact) + 2D Compatibility (PS) -25969 + (NN) -12169 + (LL) 1056 1D Compatibility (HY) -20400 + (ID) 4800 Total energy: -200270.0 ( -115.10 by residue) QMean score : 0.435

(partial model without unconserved sides chains): PDB file : Tito_2WTD.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2WTD-query.scw PDB file : Tito_Scwrl_2WTD.pdb: