Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNYPTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTKTQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGH-----PYFDKDVVVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFGACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFNEETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH 1XHC Chain:A ((9-299)) ---SKVVIVGNGPGGFELAKQLSQ-TYEVTVIDKEPVPYYSKPMLSH--YIA--------GF--IP------RNRLFPYSLDWYRKRGIEIRLAEEAKLIDRG-R-K-VVITEKGEVPYDTLVLATGA--RAREPQIKGKEYLLTLRTIFDADRIKESIENSGEAIIIGGGFIGLELAGNLAEAGYHVKLIHRGAMFL-GLDEELSNMIKDMLEETGVKFFLNSELLEANEEGVLT-NS----GFIEGKVKICAIGIVPNVDLARRSGIHTG--RG-ILIDD-NFRTSAKDVYAIGDCAEYSGIIAGTAKAAMEQARVLADIL------

General information: TITO was launched using: RESULT: Template: 1XHC.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1565 -55256 -35.31 -196.64 target 2D structure prediction score : 0.59 Monomeric hydrophicity matching model chain A : 0.72 3D Compatibility (PKB) : -35.31 2D Compatibility (Sec. Struct. Predict.) : 0.59 1D Compatibility (Hydrophobicity) : 0.72 QMean score : 0.496

(partial model without unconserved sides chains): PDB file : Tito_1XHC.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1XHC-query.scw PDB file : Tito_Scwrl_1XHC.pdb: