Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKNVAIVGDGGHGKVIRELINARSDTRLAAVLDDKFKTFEGGKEWYTGPPKAVTELRRLIPDVLFLIAVGNNSVRKQLAERLGLGKDDFITLIHPSAIVSKSAVIGE--GTVIMAGAIIQADARIGAHCIINTGAVAEHDNQISDYVHLSPRATLSGAVSVQEGAHVGTGASVIPQIIIGAWSIVGAGSAVIRSIPDRVTAAGAPARIISSIQTSNKG 2VHE Chain:A ((4-192)) -EKIYIYGASGHGLVCEDV--AKNMGYKECIFLDDFKG---------------MKFESTLPKYDFFIAIGNNEIRKKIYQKISENGFKIVNLIHKSALISPSAIVEENAGILIMPYVVINAKAKIEKGVILNTSSVIEHECVIGEFSHVSVGAKCAGNVKIGKNCFLGINSCVLPNLSLADDSILGGGATLVKNQDEKGVFVGVPAK-----------

General information: TITO was launched using: RESULT: Template: 2VHE.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1112 -111602 -100.36 -596.80 target 2D structure prediction score : 0.44 Monomeric hydrophicity matching model chain A : 0.77 3D Compatibility (PKB) : -100.36 2D Compatibility (Sec. Struct. Predict.) : 0.44 1D Compatibility (Hydrophobicity) : 0.77 QMean score : 0.524

(partial model without unconserved sides chains): PDB file : Tito_2VHE.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2VHE-query.scw PDB file : Tito_Scwrl_2VHE.pdb: