Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQP------RLEDWLDTLSLYQHTLH-ENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKSLPT---------------L----QML----------------------------DEFTQGS----------------------F----D------HQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQID-AALYEVQHGGHFLEDEGFTSLPIVYDVLTSYFSKETR 4Y7D Chain:A ((33-300)) -GPPVLVVHGSPGGH-DAGLA-MARFLVAEGLRAIVVDRPGYFGTPLGSGVTPDEQAELYAALFDALGLAAAGVLCWSGGGPSSYRLAARH--PDRVRALVSVAAVSHRYHFDGEKGAEKVLMGTGLGRRMLQLMAAHTPEKLVSATIAAEGHLSKEHVAERVAQIMADPDKERFTLELAVSANHSGPRKAGFDNDMDQFARIDSLELDRITAPTLVVSGTADSDVDPEFSRFAAAQIAGSELVHLDAGTHLAFWVH-PDSGPVRRRAAELLRA---

General information: TITO was launched using: RESULT: Template: 4Y7D.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1044 -136692 -130.93 -755.20 target 2D structure prediction score : 0.67 Monomeric hydrophicity matching model chain A : 0.68 3D Compatibility (PKB) : -130.93 2D Compatibility (Sec. Struct. Predict.) : 0.67 1D Compatibility (Hydrophobicity) : 0.68 QMean score : 0.498

(partial model without unconserved sides chains): PDB file : Tito_4Y7D.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4Y7D-query.scw PDB file : Tito_Scwrl_4Y7D.pdb: