Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTIAVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLEPVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQLFAHVPRLPHDIPVHKLITEDRIISCFS 1YDM Chain:A ((4-186)) ---QLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTIAVTISRGLEIPTRPVIEQAWEEGKQVCIPKC---TKKMQFRTYQTDDQLETVYAGLLEPV--KTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQLFAHVPRLPHDIPVHKLITEDRIISCF-

General information: TITO was launched using: RESULT: Template: 1YDM.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 848 -109272 -128.86 -613.89 target 2D structure prediction score : 0.65 Monomeric hydrophicity matching model chain A : 0.98 3D Compatibility (PKB) : -128.86 2D Compatibility (Sec. Struct. Predict.) : 0.65 1D Compatibility (Hydrophobicity) : 0.98 QMean score : 0.624

(partial model without unconserved sides chains): PDB file : Tito_1YDM.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1YDM-query.scw PDB file : Tito_Scwrl_1YDM.pdb: