Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MERKTVLYIAVSLDGMIAKEDGSIDWLDE--FEGEGDNGYSDFYQTVDTVILGRSTYEHV-KVLTP-VFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLKQEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGTKQFGQAVQLHYVRA 3JTW Chain:A ((4-178)) --RKVILFIAMSIDNYIADDQGAVDWLEKNVHGTESDDSYEKMYSKIDTVIMGRTTYEQVTQKLSPEKYVYADRQTYIVTSHLGEDTDK-IKYWKQSPVELVKRIQKEKGKDVWIVGGAKIIDPLVQANLIDTYILTTVPIFLGSGIRLFDRLEEQVPVRLIDVYQKNELVYSIYQRG

General information: TITO was launched using: RESULT: Template: 3JTW.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 768 -27273 -35.51 -159.49 target 2D structure prediction score : 0.55 Monomeric hydrophicity matching model chain A : 0.83 3D Compatibility (PKB) : -35.51 2D Compatibility (Sec. Struct. Predict.) : 0.55 1D Compatibility (Hydrophobicity) : 0.83 QMean score : 0.581

(partial model without unconserved sides chains): PDB file : Tito_3JTW.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3JTW-query.scw PDB file : Tito_Scwrl_3JTW.pdb: