@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : A4ZPY7_CHRVL: (2019-01-25 )
MSARIAERAMAALGRSGMGARATRVGGGRASEVFLVQGGDSELIAYWLPEGGAREARRRFALLERMAGQFRLAPRPLAVDEDGDAALLLVEKLEGVAPAACGPLAPDTVRRLAENFIGTLASLHALEVAPADRPPDYLRRILSEWRRRWNAEEAGGAIDADFSAVADWLTERMPETAPAAWLHNDYKLDNILVDPGDPARVVGVVDWELAAVGHPLADLGAALAYWIESRDSSLLRLDAPGPSCAPGAPTREALVDLYAAAAGREVTEPAYWYAYGLLRLAVITQQLALRRRDEGQRVPRAKLIVRWLLDRAAEACGGGRL
Atome Classification :
(22 SA)
--------------------.........10..---..-----...-----.---20...--......30....-.-----.---------..---------40.----------.......50---.------...---------.-...60..-.....-.-70.-.-.....------.---------80.----------.------.---...----..90....----....100.----------.---------.----------.-...110....---....-.120..-------...-----..130-.-----.-----.---.--..---..140--....--------------.....--------150----------..---------.-------.--------..-.------.-------------160...-----....170------.----.--.---...--.-----180.......190.....-..200.......210.......220.......230.--......240.......--250....-...260..---.----..------------.---.-.------.---270.......280.....----.--------.290.-..----------....300..-.--......310.......320---------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------MS
A
R
I
A
E
R
A
M
A
A
L---GR-----SGM-----G---A-RAT--RVGGGR
A
S
E
V
F
L
-
V
-----Q---------GG---------DS
E
----------
L
I
A
Y
WLPEG---
G
------
A
R
E
---------
A
-
R
R
R
F
A
L
L
-
E
R
M
A
G
-Q-FRL-A-PRP
L
A
------V---------DED----------G------
D
---
A
A
L
----
L
L
V
E
K
LEG----VAPAACGP----------L---------
A
----------
P
-
D
T
V
R
--
R
L
A
E
---
N
F
I
G
-
T
L
A
S
L
H
-------
A
L
E-----VAPA--D-----R-----
P
---
P
--
D
Y
---
L
R
R
----
I
L
S
E
--------------
W
R
R
RW--------N
A
-----------
E
E---------A-------G--------GA-I------D-------------
A
D
F
S
A
V
-----
A
D
W
L
T
E
R------M----P--E---TA
P
--
A
-----
A
W
LHNDYK
L
D
N
I
L
VDPGD-P
A
R
V
V
G
V
V
D
W
E
L
A
AVGH
P
L
A
D
L
G
A
A
L
A
Y
W
I
ESRDS
S
--
L
L
R
LDAPGPSCAPGA
P
--
T
R
E
A
L
V
D
-
L
Y
A
A
--AA---G----RE------------V---T-E------
P
---
A
Y
W
Y
A
Y
G
L
L
R
L
A
V
I
T
Q
Q
L
----
A
--------
L
RRRD-EG----------QRV
P
R
--
A
K
-
L
--
I
V
R
W
L
L
D
R
A
A
E
ACGGGRL----------------
23
Fugue
81.16
20%
-10
- C2 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
-------------------T
L
P
A
V
I
S
R
W
L
S
S
V
L
PGG
A
A
-----
P
E
V
-----
T
---
V
-
E
S
G
--
V
D
S
T
G
M
S
S
E
T
I
I
-
L
T
A
R
W
Q
Q
---------
D
G
---------
R
S
I
----------
Q
Q
K
L
V
A
R
V
A
---
P
------
A
A
E
DVPVFPTYR
L
-
D
H
Q
F
E
V
I
-
R
L
V
G
E
-
L
-
T
D
V
P
V
-
P
R
V
R
W
------
I
---------
E
T
T
----------
G
------
D
VLG
T
P
F
----
F
L
M
D
Y
V
E
G
----
V
V
P
P
D
V
M
P
----------
Y
---------
T
FGDNWFADAP
A
-
E
R
Q
R
--
Q
L
Q
D
---
A
T
V
A
-
A
L
A
T
L
H
-------
S
I
P
-----
N
A
Q
N
T
F
S
-----
F
-----
L
---
T
--
D
T
---
T
L
H
----
R
H
F
N
--------------
W
V
R
S
W
--------
Y
D
-----------
F
A
---------
V
-------
E
--------
G
I
G
R
------
S
-------------
P
L
L
E
R
T
-----
F
E
W
L
Q
S
H
------
W
----
P
--
D
---
D
A
A
--
A
REP--
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
F
----
Q
P
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
W
M
I
F
A
H
R
V
F
Q
E
L
A
--
G
L
----
A
T
L
P
G
L
P
E
V
M
--
R
E
D
D
V
R
A
-
T
Y
Q
A
--
L
T
---
G
----
V
E
------------
L
---
G
-
D
------
L
---
H
W
F
Y
V
Y
S
G
V
M
W
A
C
V
F
M
R
T
----
G
--------
A
R
R
V
H
-
F
G
----------
E
I
E
K
P
--
D
D
-
V
--
E
S
L
F
Y
H
A
G
L
M
K
H
L
L
G
E
E
H
----------------
38
HHSearch
80.36
22%
-37
- C2 -
-
3DXP
1
?
A:
[41-357]
-------------------------------------------------------
L
-
S
V
E
--
Q
F
K
G
-
Q
S
N
P
T
F
K
-
L
-----
V
---------
T
P
---------
G
Q
T
----------
Y
V
M
R
A
K
P
G
-------------
A
---------
I
-
E
R
E
Y
R
V
M
-
D
A
L
A
G
-
T
-
D
V
P
-
V
-
A
K
M
Y
A
------
L
---------
C
E
D
----------
E
SVI---
G
---
R
A
F
----
Y
I
M
E
F
V
S
G
----
R
V
L
W
D
Q
S
L
PG--------
M
---------
S
----------
P
-
A
E
R
T
--
A
I
Y
D
---
E
M
N
R
-
V
I
A
A
M
H
-------
T
V
D
-----
Y
Q
A
I
--
G
-----
L
GDYGK
P
---
G
--
N
Y
---
F
Q
R
----
Q
I
E
R
--------------
W
T
K
Q
Y
--------
K
L
-----------
S
E
-----------------
T
--------
E
S
-
I
--------------------
P
A
M
D
S
L
-----
M
D
W
L
P
Q
H
------
I
----
P
--
Q
ED-
A
D
L
--
T
-----
S
I
V
H
G
D
Y
R
L
D
N
L
M
F
H
P
T
E
--
P
R
V
L
A
V
L
D
W
E
L
S
T
L
G
H
P
M
G
D
F
G
Y
H
C
M
S
W
H
I
A
P
G
Q
F
--
R
G
I
A
-
G
-
L
D
H
A
A
L
G
I
P
--
D
E
A
S
Y
R
K
-
L
Y
E
Q
--
R
T
---
G
----
R
P
------------
I
T--
G
-
D
------
W
---
N
F
Y
L
A
F
S
M
F
R
I
A
G
I
L
Q
G
I
----
M
--------
K
R
V
V
D
-
G
T
----------
A
S
S
A
Q
--
A
L
D
A
G
K
R
A
R
P
M
A
E
M
G
W
E
Y
A
K
K
A
------------------
39
HHSearch
77.98
20%
-11
- C2 -
-
3ATS
1
Y3168_MYCTU
A:
[4-336]
----------------------
A
V
I
S
R
W
L
S
S
V
L
---
P
G
-----
G
A
A
-----
P
E
--
V
-
T
V
E
SG
V
D
S
T
G
M
S
S
E
T
I
I
-
L
-----
T
---------
A
R
W
Q
Q
DG
R
S
I
-
Q
Q
K
----------
L
V
A
R
V
A
P
A
A
---
E
DVPVFP
T
Y
R
---------
L
-
D
H
Q
F
E
V
I
-
R
L
V
G
E
L
T
-
D
V
P
-
V
-
P
R
V
R
W
------
I
---------
E
T
T
----------
G
DVL---
G
---
T
P
F
----
F
L
M
D
Y
V
E
G
----
V
V
P
P
D
V
M
P
YTFGDNWFAD
A
---------
P
----------
A
-
E
R
Q
R
--
Q
L
Q
D
---
A
T
V
A
-
A
L
A
T
L
H
-------
S
I
P
-----
N
A
Q
N
--
T
-----
F
-----
S
FLT-D-
T
T
---
L
H
R
----
H
F
N
W
--------------
V
R
S
W
Y
--------
D
F
-----------
A
V
---------
E
-------
G
--------
I
G
-
R
------
S
-------------
P
L
L
E
R
T
-----
F
E
W
L
Q
S
H
------
W
----
P
--
D
D
A
A
A
R
E
--
P
-----
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
F
----
Q
P
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
W
M
I
F
A
H
R
V
F
Q
E
L
A
--
G
L
A
----
T
L
P
G
L
P
E
V
M
--
R
E
D
D
V
R
A
-
T
Y
Q
A
--
L
T
---
G
----
V
E
------------
L
---
G
-
D
------
L
---
H
W
F
Y
V
Y
S
G
V
M
W
A
C
V
F
M
R
T
----
G
--------
A
R
R
V
H
F
G
E
----------
I
E
K
P
-------------------------------------------
40
HHSearch
76.56
20%
-11
- C2 -
-
3ATT
2
Y3168_MYCTU
A:
[4-336]
----------------------
A
V
I
S
R
W
L
S
S
V
L
---
P
G
-----
G
A
A
-----
P
E
--
V
-
T
V
E
SG
V
D
S
T
G
M
S
S
E
T
I
I
-
L
-----
T
---------
A
R
W
Q
Q
DG
R
S
I
-
Q
Q
K
----------
L
V
A
R
V
A
P
A
A
---
E
DVPVFP
T
Y
R
---------
L
-
D
H
Q
F
E
V
I
-
R
L
V
G
E
L
T
-
D
V
P
-
V
-
P
R
V
R
W
------
I
---------
E
T
T
----------
G
DVL---
G
---
T
P
F
----
F
L
M
D
Y
V
E
G
----
V
V
P
P
D
V
M
P
YTFGDNWFAD
A
---------
P
----------
A
-
E
R
Q
R
--
Q
L
Q
D
---
A
T
V
A
-
A
L
A
T
L
H
-------
S
I
P
-----
N
A
Q
N
--
T
-----
F
-----
S
FLT-D-
T
T
---
L
H
R
----
H
F
N
W
--------------
V
R
S
W
Y
--------
D
F
-----------
A
V
---------
E
-------
G
--------
I
G
-
R
------
S
-------------
P
L
L
E
R
T
-----
F
E
W
L
Q
S
H
------
W
----
P
--
D
D
A
A
A
R
E
--
P
-----
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
F
----
Q
P
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
W
M
I
F
A
H
R
V
F
Q
E
L
A
--
G
L
A
----
T
L
P
G
L
P
E
V
M
--
R
E
D
D
V
R
A
-
T
Y
Q
A
--
L
T
---
G
----
V
E
------------
L
---
G
-
D
------
L
---
H
W
F
Y
V
Y
S
G
V
M
W
A
C
V
F
M
R
T
----
G
--------
A
R
R
V
H
F
G
E
----------
I
E
K
P
-------------------------------------------
37
Fugue
72.18
15%
-17
- C2 -
-
4OCV
2
?
A:
[24-378]
---------------------
T
N
E
A
L
F
D
V
A
S
H
F
---
A
L
-----
E
G
T
-----
V
---
D
-
S
I
E
--
P
Y
G
D
G
H
I
N
T
T
Y
L
-
V
-----
T
---------
T
D
---------
G
P
R
----------
Y
I
L
Q
R
M
N
T
G
---
I
------
F
P
D
---------
T
-
V
N
L
M
R
N
V
-
E
L
V
T
S
-
T
-
L
K
A
-
Q
G
K
E
T
L
D
------
I
V
R
T
TSGDTW
A
E
I
----------
D
------
G
---
G
A
W
----
R
V
Y
K
F
I
E
H
----
T
M
S
Y
N
L
V
P
--------------------
N
----------
P
-
D
V
F
R
--
E
A
G
R
A
F
G
D
F
Q
N
-
F
L
S
G
F
D
-------
A
N
Q
-----
L
T
E
T
--
I
-----
A
-----
H
---
F
--
H
D
---
T
P
H
----
R
F
E
D
--------------
F
K
K
A
L
--------
A
A
-----------
D
E
LGRA-----
A
-------
G
--------
C
G
-
P
------
E
-------------
I
E
F
Y
L
S
H
ADQY
A
V
V
M
D
G
L
------
R
----
D
--
G
---
S
I
P
--
L
-----
R
V
T
H
N
D
T
K
L
N
N
I
L
M
D
A
T
T
-
G
-
K
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
S
I
R
F
G
A
----
S
T
--
A
L
E
D
E
R
D
L
D
K
V
H
F
S
T
E
--
L
F
R
A
Y
T
E
-
G
F
V
G
--
E
L
---
R
----
D
S
------------
I
T
A
R
E
-
A
------
E
---
L
L
P
F
S
G
N
L
L
T
M
E
C
G
M
R
F
L
----
A
D
Y
L
E
GDVY
F
A
T
K
Y
-
P
E
----------
H
N
L
V
R
--
S
R
-
T
--
Q
I
K
L
V
R
E
M
E
Q
R
A
D
E
T
R
A
I
V
A
D
V
M
E
T
T--------
35
Fugue
71.95
17%
1
- C2 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
---
G
G
-----
A
W
K
TVPLE
H
---
L
-
R
I
S
--
R
I
K
G
G
M
S
N
M
L
F
L
-
C
-----
R
L
S
EVYPPIR
N
E
---------
P
N
K
----------
V
L
L
R
V
Y
F
N
P
---
E
------
T
E
S
---------
H
-
L
V
A
E
S
V
I
-
F
T
L
L
S
-
E
-
R
H
L
-
G
-
P
K
L
Y
G
------
I
---------
F
S
G
----------
G
-----------------
R
L
E
E
Y
I
P
S
----
R
P
----------------
L
---------
S
----------
C
-
H
E
I
S
L
A
H
M
S
T
---
K
I
A
K
-
R
V
A
K
V
H
-------
Q
L
E
-----
V
-
P
I
--
W
-----
K
-----
E
---
P
--
D
Y
---
L
C
E
----
A
L
Q
R
--------------
W
L
K
Q
L
--------
T
G
T
V
DAE
H
R
F
D
L
P
E
E
---------
C
-------
G
--------
V
S
-
S
VN----
C
-------------
L
D
L
A
R
E
-----
L
E
F
L
R
A
H
------
I
----
S
--
L
S--
K
S
P
--
V
-----
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
R
------
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
I
D
Y
D
I
D
--
E
A
P
F
Y
K
I
Q
T
E
N
F
P
E
N
D
--
Q
M
L
E
F
F
L
-
N
Y
L
R
--
E
Q
---
G
NTRE
N
E
------------
L
---
Y
-
K
------
K
---
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
--------
L
L
Q
V
E
-
L
S
----------
P
V
G
F
G
--
F
A
-
D
--
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA--------------
30
Fugue
70.04
17%
-21
* C2 *
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
---------------------
T
D
I
T
E
D
E
L
R
N
F
L
---
T
Q
-----
Y
D
V
-----
G
---
S
-
L
T
S
--
Y
K
G
I
A
E
N
S
N
F
L
L
-
H
-----
T
---------
T
K
---------
D
P
L
----------
I
L
T
L
Y
E
K
-------------
K
N
---------
D
-
L
P
F
F
L
G
L
M
Q
H
L
A
A
-
K
-
G
L
S
-
C
-
P
L
P
L
P
R
KDGEL
L
---------
G
E
L
----------
S
------
G
---
R
P
A
----
A
L
I
S
F
L
E
G
M
---
W
L
R
----
K
----------
P
---------
E
----------
A
-
K
H
C
R
--
E
V
G
K
---
A
L
A
A
M
H
L
A
S
E
G
-------
F
E
I
-----
K
R
P
N
--
A
-----
L
-----
S
---
V
--
D
G
---
W
K
V
----
L
W
D
K
--------------
S
E
E
R
A
--------
D
E
-----------
V
E
---------
K
-------
G
-----------
L
------
R
-------------
E
E
I
R
P
E
-----
I
D
Y
L
A
A
H
------
W
----
P
--
K
---
D
L
P
--
A
-----
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
D
----
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
A
W
C
F
E
K
D
G
A
--
Y
------------
N
V
T
--
K
G
K
A
L
L
E
-
G
Y
Q
S
--
V
R
P
L
S
E
----
A
E
------------
L
---
E
-
A
------
L
---
P
L
L
S
R
G
S
A
L
R
F
F
L
T
R
L
Y
D
----
W
--------
L
T
T
P
A
-
G
A
----------
L
V
V
K
K
--
D
P
-
L
--
E
Y
L
R
K
L
R
F
H
R
T
I
A
N
V
A
E
Y
GLA-------------
1
PsiBlast_PDB
68.16
26%
-58
- C2 -
-
3DXP
1
?
A:
[115-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
F
Y
------
I
---------
M
E
F
----------
V
------
S
---
G
R
V
----
L
W
D
Q
S
L
P
G
----
M
S
P
A
E
R
T
A
----------
I
---------
Y
----------
D
-
E
M
N
R
--
V
I
A
A
---
M
H
T
----
V
D
Y
Q
-------
A
I
G
-----
L
G
D
Y
--
G
-----
K
-----
P
---
G
--
N
Y
---
F
Q
R
----
Q
I
E
R
--------------
W
T
K
Q
Y
--------
K
L
-----------
S
E
---------
T
-------
E
--------
S
I
-
P
------
A
-------------
M
D
--
S
L
-----
M
D
W
L
P
Q
H
------
I
----
P
--
Q
---
E
D
A
DL
T
-----
S
I
V
H
G
D
Y
R
L
D
N
L
M
F
H
P
T
E
-
P
-
R
V
L
A
V
L
D
W
E
L
S
T
L
G
H
P
M
G
D
F
G
Y
H
C
M
S
W
H
I
A
--
P
G
--
Q
F
R
G
I
A
G
L
D
H
A
A
L
G
I
P
--
D
E
A
S
Y
R
K
-
L
Y
E
Q
--
R
T
---
G
----
R
P
------------
I
---
T
G
D
------
W
---
N
F
Y
L
A
F
S
M
F
R
I
A
G
I
L
Q
G
I
----
M
--------
K
R
V
V
D
------------------------------------------------------------
60
SP3
68.12
14%
4
- C2 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
---
G
G
AWKTV
P
L
E
-----
H
---
L
-
R
I
S
--
R
I
K
G
G
M
S
N
M
L
F
L
-
C
-----
R
---------
L
S
---------
E
V
Y
PPIRNEPN
K
V
L
L
R
V
Y
F
N
P
E
---
T
------
E
S
H
---------
L
-
V
A
E
S
V
I
F
-
T
L
L
S
E
-
R
-
H
L
--
G
-
P
K
L
Y
G
------
I
---------
F
S
G
-----------------------
G
----
R
L
E
E
Y
I
P
S
----
R
P
L
----
S
----------
C
---------
H
----------
E
-
I
S
L
A
--
H
M
S
T
---
K
I
A
K
-
R
V
A
K
V
H
-------
Q
L
E
-----
V
-
P
I
--
W
-----
K
-----
E
---
P
--
D
Y
---
L
C
E
----
A
L
Q
R
--------------
W
L
K
Q
L
--------
T
G
-----------
T
V
---------
D
-------
A
--------
E
H
-
R
------
F
D
L
PEECGVSSVN
C
L
D
L
A
R
E
-----
L
E
F
L
R
A
H
------
I
----
S
--
L
S--
K
S
P
--
V
-----
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
R
------
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
I
D
Y
D
I
D
--
E
A
P
F
Y
K
I
Q
T
E
N
F
P
E
N
D
--
Q
M
L
E
F
F
L
-
N
Y
L
R
--
E
Q
---
G
----
N
T
------------
R
---
E
-
N
E
L
Y
K
K
S
E
---
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
----
V
--------
W
G
L
L
Q
-
V
E
----------
L
S
P
V
G
FG
F
A
-
D
--
Y
G
R
D
R
L
S
L
Y
F
K
H
--
K
Q
L
L
K
N
LA------------
29
Fugue
63.78
14%
-24
- C2 -
-
3HAM
3
?
A:
[1-299]
---------------------
M
V
N
L
D
A
E
I
Y
E
H
L
---
N
K
-----
Q
I
K
-----
I
---
N
-
E
L
R
--
Y
L
S
S
G
D
D
S
D
T
F
L
-
C
----------------
N
---------
E
Q
Y
----------
V
V
K
V
P
K
R
D
S
---
V
------
R
I
S
---------
Q
-
K
R
E
F
E
L
Y
-
R
F
L
E
N
-
C
-
K
L
S
-
Y
-
Q
I
P
A
V
------
V
---------
Y
Q
S
----------
D
------
R
---
F
N
I
----
M
K
Y
I
K
G
E
R
----
I
T
Y
E
Q
Y
H
K
----------
L
---------
S
----------
E
-
K
E
K
D
--
A
L
A
Y
---
D
E
A
T
-
F
L
K
E
L
H
-------
S
I
E
IDCSV
S
L
F
S
--
D
-----
A
-----
L
---
V
--
N
K
---
K
D
K
----
F
L
Q
D
--------------
K
K
L
L
I
--------
S
I
-----------
L
E
---------
K
-------
E
--------
Q
L
-
L
------
T
-------------
D
E
M
L
E
H
-----
I
E
T
I
Y
E
N
------
I
----
L
--
N
---
N
A
V
--
L
F
K
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
N
N
----
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
L
L
D
C
S
----------------------
T
D
D
--
F
G
K
E
F
G
R
-
K
V
L
K
--
Y
Y
---
Q
----
H
K
------------
A
---
P
-
E
------
V
---
A
E
R
K
A
E
L
N
D
V
Y
W
S
I
D
Q
I
I
----
Y
--------
G
Y
E
R
K
-
D
R
----------
E
M
L
I
K
--
G
V
-
S
--
E
L
L
Q
T
Q
A
E
M
F
I
F
----------------------
28
Fugue
60.67
16%
1
- C2 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
--------------------
A
K
M
R
I
S
P
E
L
K
K
L
I
---
E
K
-----
Y
-----------
R
-
C
V
K
--
D
T
E
G
M
S
P
A
K
V
Y
K
-
L
-----
V
---------
G
E
---------
N
E
N
----------
L
Y
L
K
M
T
D
S
R
YKG
T
------
T
Y
D
---------
V
-
E
R
E
K
D
M
M
-
L
W
L
E
G
-
K
-
L
P
V
---
P
K
V
L
H
------
F
---------
E
R
H
----------
D
------
G
---
W
S
N
----
L
L
M
S
E
A
D
G
----
V
L
C
S
E
E
-
Y
----------
E
---------
D
----------
E
-
Q
S
P
E
--
K
I
I
E
---
L
Y
A
E
-
C
I
R
L
F
H
-------
S
I
D
-----
I
S
D
C
--
P
-----
Y
-----
T
---
N
--
S
----
L
D
S
----
R
L
A
E
--------------
L
D
Y
L
L
N
N
DLADVD
C
E
-----------
N
W
---------
E
-------
E
--------
D
T
-
P
------
F
-------------
K
D
P
R
E
L
-----
Y
D
F
L
K
T
E
------
K
----
P
--
E
---
E
-
E
--
L
-----
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
----
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
E
D
I
G
E
-----------------------
E
Q
Y
V
E
-
L
F
F
D
--
L
L
---
G
----
I
K
------------
P
---
D
-
W
------
E
---
K
I
K
Y
Y
I
L
L
D
E
L
F
------------------------------------------------------------------------------------
42
HHSearch
59.58
16%
-9
- C2 -
-
2PPQ
-
KHSE_AGRFC
A:
[9-288]
-------------------------
E
D
E
L
R
N
F
L
---
T
Q
-----
Y
D
V
-----
G
SL-
T
-
S
Y
K
--
G
I
A
E
---
N
S
N
F
L
-
L
-----
H
---------
T
T
---------
K
D
P
----------
L
I
L
T
L
Y
E
K
-----------
K
N
D
---------
L
-
P
F
F
L
G
L
M
-
Q
H
L
A
A
-
K
-
G
L
S
-
C
-
P
L
P
L
P
------
R
---------
K
D
G
----------
E
L
L
G
E
L
S
G
---
R
P
A
----
A
L
I
S
F
L
E
G
----
M
W
L
R
K
P
----------------------
E
---------------
A
--
K
H
C
R
---
E
V
G
K
-
A
L
A
A
M
H
-------
L
A
S
-----
E
G
F
---
E
-----
I
-----
K
---
R
--
P
N
----
A
L
----
S
V
D
G
--------------
W
K
V
L
W
--------
D
K
-----------
S
E
---------
E
RADEV--
E
--------
K
G
-
L
------
R
-------------
E
E
I
R
P
E
-----
I
D
Y
L
A
A
H
------
W
----
P
--
K
---
D
L
P
--
A
-----
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
D
----
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
A
W
C
F
E
K
D
G
--------------
A
Y
N
V
T
--
K
G
K
A
L
L
E
-
G
Y
Q
S
--
V
R
---
P
----
L
S
------------
E
---
A
-
E
------
L
---
E
A
L
P
L
L
S
R
G
S
A
L
R
F
F
L
T
R
----
L
--------
Y
D
W
L
T
-
T
P
---------------------------------------------------------
54
HHSearch
58.60
16%
-3
- C2 -
-
1NW1
-
CKA2_CAEEL
A:
[77-391]
---------------------------------------------------------
R
I
S
--
R
I
K
G
G
M
S
N
M
L
F
L
-
C
-----
R
---------
L
S
EVYPPIRNE
P
N
K
----------
V
L
L
R
V
Y
F
N
P
E--
T
------
E
S
H
---------
L
-
V
A
E
S
V
I
F
-
T
L
L
S
E
-
R
-
H
L
G
---
P
K
L
Y
G
------
I
---------
F
S
-----------------------
G
G
----
R
L
E
E
Y
I
P
S
----
R
P
L
S
C
H
---------------------------------
E
-
I
S
L
A
--
H
M
S
T
---
K
I
A
K
-
R
V
A
K
V
H
-------
Q
L
E
-----
V
P
I
W
--
K
-----
E
-----
P
------
D
Y
---
L
C
E
----
A
L
Q
R
--------------
W
L
K
Q
L
--------
T
G
-----------
T
V
---------
D
AE
H
R
F
D
L
P
--------
E
E
-
C
GVSSVN
C
-------------
L
D
L
A
R
E
-----
L
E
F
L
R
A
H
------
I
----
S
L
-
S
---
K
S
P
--
V
-----
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
I
D
Y
D
I
D
--
E
A
P
F
Y
K
I
Q
T
E
N
F
P
E
N
D
--
Q
M
L
E
F
F
L
-
N
Y
L
R
--
E
Q
---
G
----
N
T
RENE
L
Y
K
K
S
E
D
L
V
---
Q
-
E
------
T
---
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
---------------------------------------------------------------------------------
53
HHSearch
58.57
16%
-2
- C2 -
-
1NW1
-
CKA2_CAEEL
B:
[77-391]
---------------------------------------------------------
R
I
S
--
R
I
K
G
G
M
S
N
M
L
F
L
-
C
-----
R
---------
L
S
EVYPPIRNE
P
N
K
----------
V
L
L
R
V
Y
F
N
P
E--
T
------
E
S
H
---------
L
-
V
A
E
S
V
I
F
-
T
L
L
S
E
-
R
-
H
L
G
---
P
K
L
Y
G
------
I
---------
F
S
-----------------------
G
G
----
R
L
E
E
Y
I
P
S
----
R
P
L
S
C
H
---------------------------------
E
-
I
S
L
A
--
H
M
S
T
---
K
I
A
K
-
R
V
A
K
V
H
-------
Q
L
E
-----
V
P
I
W
--
K
-----
E
-----
P
------
D
Y
---
L
C
E
----
A
L
Q
R
--------------
W
L
K
Q
L
--------
T
G
-----------
T
V
---------
D
AE
H
R
F
D
L
P
--------
E
E
-
C
GVSSVN
C
-------------
L
D
L
A
R
E
-----
L
E
F
L
R
A
H
------
I
----
S
L
-
S
---
K
S
P
--
V
-----
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
I
D
Y
D
I
D
--
E
A
P
F
Y
K
I
Q
T
E
N
F
P
E
N
D
--
Q
M
L
E
F
F
L
-
N
Y
L
R
--
E
Q
---
G
----
N
T
RENE
L
Y
K
K
S
E
D
L
V
---
Q
-
E
------
T
---
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
---------------------------------------------------------------------------------
3
PsiBlast_PDB
57.77
24%
6
- C2 -
-
3ATS
1
Y3168_MYCTU
A:
[82-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
V
G
-
E
-
L
T
D
-
V
-
P
V
P
R
V
RW----
I
---------
E
T
T
----------
G
------
D
VLG
T
P
F
----
F
L
M
D
Y
V
E
G
----
V
V
P
P
D
V
M
P
----------
Y
TFGDNWFAD
A
----------
P
A
E
R
Q
R
--
Q
L
Q
D
---
A
T
V
A
-
A
L
A
T
L
H
-------
S
I
P
-----
N
A
Q
N
--
T
F
SFLT-------------
D
T
---
T
L
H
----
R
H
F
N
--------------
W
V
R
S
W
Y
-------
D
F
-----------
A
V
---------
E
-------
G
--------
I
G
-
R
------
S
-------------
P
L
L
E
R
T
-----
F
E
W
L
Q
S
H
------
W
----
P
--
D
---
D
A
A
--
A
REP--
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
F
Q
-
P
---
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
-----
W
M
I
F
A
H
R
V
--
F
Q
E
L
--
A
G
L
A
T
L
P
G
L
P
EV
M
R
E
D
D
V
R
A
T
Y
Q
A
--
L
T
---
G
----
V
E
------------
L
---
G
-
D
------
L
---
H
W
F
Y
V
Y
S
G
V
M
W
A
C
V
F
M
R
T
----
G
--------
A
R
R
V
H
-
F
G
----------
E
----------------------------------------------
4
PsiBlast_PDB
57.69
24%
0
- C2 -
-
3ATT
2
Y3168_MYCTU
A:
[82-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
V
G
-
E
-
L
T
D
-
V
-
P
V
P
R
V
RW----
I
---------
E
T
T
----------
G
------
D
VLG
T
P
F
----
F
L
M
D
Y
V
E
G
----
V
V
P
P
D
V
M
P
----------
Y
TFGDNWFAD
A
----------
P
A
E
R
Q
R
--
Q
L
Q
D
---
A
T
V
A
-
A
L
A
T
L
H
-------
S
I
P
-----
N
A
Q
N
--
T
F
SFLT-------------
D
T
---
T
L
H
----
R
H
F
N
--------------
W
V
R
S
W
Y
-------
D
F
-----------
A
V
---------
E
-------
G
--------
I
G
-
R
------
S
-------------
P
L
L
E
R
T
-----
F
E
W
L
Q
S
H
------
W
----
P
--
D
---
D
A
A
--
A
REP--
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
F
Q
-
P
---
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
-----
W
M
I
F
A
H
R
V
--
F
Q
E
L
--
A
G
L
A
T
L
P
G
L
P
EV
M
R
E
D
D
V
R
A
T
Y
Q
A
--
L
T
---
G
----
V
E
------------
L
---
G
-
D
------
L
---
H
W
F
Y
V
Y
S
G
V
M
W
A
C
V
F
M
R
T
----
G
--------
A
R
R
V
H
-
F
G
----------
E
----------------------------------------------
41
HHSearch
57.04
18%
10
- C2 -
-
6EF6
2
?
A:
[28-323]
-------------------------
V
T
I
A
Q
Q
A
L
---
T
H
-----
Y
D
V
-----
S
DN-
A
-
S
L
R
--
L
L
-
N
L
S
E
N
A
T
Y
L
-
V
-----
E
---------
D
G
---------
E
H
Q
----------
S
I
L
R
V
H
R
Q
D
YH-
Q
------
P
H
E
---------
I
-
E
S
E
L
D
W
L
-
A
A
L
R
T
D
S
-
D
V
T
-
V
-
P
T
V
V
P
------
A
---------
R
D
G
RR
V
V
T
V
D
P
A
D
V
------
P
---
R
H
V
----
V
H
F
E
M
V
G
G
----
A
E
P
D
E
E
S
-----------------------------------
L
T
L
--
D
D
F
Q
---
T
L
G
R
-
I
T
A
S
L
H
-------
E
H
S
-----
Q
R
W
T
--
R
-----
P
-----
A
G
F
-
G
R
F
S
W
D--
W
E
H
CLG-
D
T
P
R
--------------
W
G
R
W
Q
--------
D
A
-----------
E
G
---------
V
-------
G
--------
A
S
-
E
------
T
-------------
A
L
L
T
R
A
-----
Q
D
L
L
H
R
K
------
L
E
E
Y
G
S
--
G
---
P
D
R
--
Y
-----
G
L
I
H
A
D
L
R
L
A
N
L
L
V
D
S
S
T
-
P
Q
R
T
I
T
V
I
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
G
T
A
V
S
F
I
E
H
D
P
R
-----------------
L
G
E
--
W
Q
E
S
W
V
A
-
G
Y
R
S
--
R
R
---
E
----
L
P
------------
A
---
A
-
D
------
E
---
A
M
L
P
S
F
V
F
L
R
R
L
L
L
L
A
W
M
----
G
--------
S
H
T
H
-------------------------------------------------------------
25
Fugue
56.08
15%
11
- C2 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
----------------KTPL
Y
E
T
L
N
E
S
S
A
V
A
L
A
---
V
K
-----
L
G
L
-----
T
---
L
-
T
C
Q
--
E
I
G
D
G
N
L
N
Y
V
F
H
-
I
-----
Y
---------
D
-----------
R
A
----------
L
I
I
K
Q
A
V
P
Y
WPL
T
------
I
D
R
---------
A
-
R
I
E
S
S
A
L
-
I
R
Q
G
E
-
H
-
V
P
H
-
L
-
V
-
P
R
V
------
F
---------
Y
S
D
----------
T
------
E
---
M
A
V
----
T
V
M
E
D
L
S
H
LKI
A
R
K
G
L
I
E
G
E
----------
N
---------
Y
----------
P
-
H
L
S
Q
--
H
I
G
E
---
F
L
G
K
-
T
L
F
Y
S
S
DYALE
P
K
V
K
K
-----
Q
L
V
K
--
Q
-----
F
-----
T
---
N
--
P
E
---
L
C
D
----
I
T
E
R
LVFTDPFFDHDT
N
D
F
E
E
E
L
--------
R
P
-----------
F
V
---------
E
-------
K
--------
L
W
-
N
------
N
-------------
D
S
V
K
I
E
-----
A
A
K
L
K
K
S
------
F
----
L
--
T
---
S
-
A
--
E
-----
T
L
I
H
G
D
L
H
T
G
S
I
F
A
S
E
H
E
-----
T
K
V
I
D
P
E
F
A
F
Y
G
P
I
G
F
D
V
G
Q
F
I
A
N
L
F
L
N
A
L
S
R
DG
A
D
R
E
P
L
Y
E
H
V
N
Q
V
W
E
T
--
F
E
E
T
F
S
E
-
A
W
Q
K
--
D
S
---
L
----
D
V
------------
Y
---
A
-
N
------
I
DG
Y
L
T
D
T
L
S
H
I
F
E
E
A
I
G
F
A
G
C
----
E
--------
L
I
R
R
T
-
I
G
LAHV
A
D
L
D
T
I
V
P
F
D
K
--
R
I
-
G
--
R
K
R
L
A
L
E
T
G
T
A
F
I
E
K
R
S
E
FKT
I
T
D
V
I
E
L
F
K
L
L
V
K
57
HHSearch
54.60
12%
-3
- C2 -
-
4OCV
2
?
A:
[25-334]
-------------------------
N
E
A
L
F
D
V
A
---
S
H
-----
F
A
L
-----
E
GTV
D
-
S
I
E
--
P
Y
G
D
G
H
I
N
T
T
Y
L
-
V
-----
T
---------
T
D
---------
G
P
R
----------
Y
I
L
Q
R
M
N
T
G
---
I
FPD---
T
V
N
---------
L
M
R
N
V
E
L
V
T
-
S
T
L
K
A
-
Q
-
G
K
E
-
T
-
L
D
I
V
R
------
T
---------
T
S
G
DTWAEI----
D
------
G
---
G
A
W
----
R
V
Y
K
F
I
E
H
----
T
M
S
Y
N
L
V
-----------------------------------
P
N
P
--
D
V
F
R
---
E
A
G
R
-
A
F
G
D
F
Q
-------
N
F
L
-----
S
G
F
D
--
A
-----
N
-----
Q
---
L
--
T
E
---
T
I
A
HFHD
T
P
H
R
--------------
F
E
D
F
K
--------
K
A
-----------
L
A
---------
A
DELGR--
A
--------
A
G
-
C
------
G
P
E
I
----------
E
F
Y
L
S
H
-----
A
D
Q
Y
A
V
V
M
D
G
L
--
R
----
D
--
G
---
S
I
P
--
L
-----
R
V
T
H
N
D
T
K
L
N
N
I
L
M
D
A
T
T
--
G
K
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
S
I
R
F
G
A
S
T
A
L
E
D
--
E
R
D
----
L
D
K
V
H
F
S
T
E
--
L
F
R
A
Y
T
E
-
G
F
V
G
E
L
R
D
---
S
----
I
T
------------
A
---
R
-
E
------
A
---
E
L
L
P
F
S
G
N
L
L
T
M
E
C
G
M
R
F
----
L
--------
A
D
Y
L
E
-
G
----------------------------------------------------------
47
HHSearch
54.18
18%
-8
- C2 -
-
5IGI
3
?
A:
[9-258]
-------------------------
T
S
Q
L
Y
A
L
A
---
A
R
-----
H
G
L
-----
K
L
H
-
G
-
P
L
T
--
V
N
E
L
G
L
D
Y
R
I
V
I
-
A
-----
T
---------
V
D
D--------
G
R
R
----------
W
V
L
R
I
P
R
R
A
E
--
V
------
S
A
K
---------
V
-
E
P
E
A
R
V
L
-
A
M
L
K
N
-
R
L
P
F
A
-
V
-
P
D
W
R
V
------
A
---------
N
A
E
----------
L
V
-----
A
---
Y
P
M
LEDS
T
A
-
V
I
Q
P
G
----
S
S
T
P
D
W
V
---------------------
V
----------
P
-
Q
D
S
E
--
V
F
A
E
---
S
F
A
T
-
A
L
A
A
L
H
-------
A
V
P
-----
I
S
A
A
--
V
-----
D
-----
A
---
G
--
M
L
IRT
P
T
Q
----
A
R
Q
K
--------------
V
A
D
D
V
--------
D
R
-----------
V
R
---------
R
E
------
F
--------
V
V
-
N
------
D
-------------
K
R
L
H
R
W
-----
Q
R
W
L
D
D
D
------
S
----
S
--
W
---
P
D
F
--
S
-----
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T
---
E
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
L
M
V
F
G
E
----------------------
E
--
G
L
A
K
L
L
L
-
T
Y
E
A
--
A
G
---
G
----
R
V
-----------------------------------------------------------------------------------------------------------------------------
45
HHSearch
51.91
17%
-22
- C2 -
-
3CSV
9
?
A:
[6-277]
-------------------------
E
D
E
I
R
D
F
L
---
A
T
-----
H
G
Y
-----
A
D--
W
-
N
R
T
--
P
--------
R
Y
Q
R
L
-----
R
---------
S
P
T--------
G
A
K
----------
A
V
L
M
D
W
S
P
E
---
E
------
G
G
D
---------
T
-
Q
P
F
V
D
L
A
-
Q
Y
L
R
N
-
L
-
D
I
S
-
A
-
P
E
I
Y
A
------
E
---------
E
H
A
---------------------
R
G
L
----
L
L
I
E
D
L
G
D
----
A
L
F
T
E
V
I
N
----------
N
---------
D
----------
P
-
A
Q
E
M
--
P
L
Y
R
---
A
A
V
D
-
L
L
I
H
L
H
-------
D
A
Q
-----
T
P
E
L
--
A
-----
R
-----
L
---
D
P
-
E
T
---
L
S
E
----
M
T
R
L
A-------------
F
S
E
Y
R
--------
Y
A
-----------
I
L
-----------------
G
--------
D
A
-
A
------
E
-------------
D
N
R
K
R
F
-----
E
H
R
F
A
Q
I
------
L
----
S
A
Q
L
---
E
G
D
--
M
-----
V
F
V
H
R
D
F
H
A
Q
N
L
L
W
L
P
E
R
E
G
L
A
R
V
G
V
I
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
V
S
L
L
Q
D
A
R
R
D
V
P
------------------
A
Q
--
V
E
A
Q
M
I
D
-
H
Y
I
Q
--
A
T
---
G
----
V
D
------------
E
---
S
-
H
------
F
R
--
S
A
Y
A
V
I
A
V
Q
R
N
M
R
I
L
G
I
F
------------------------------------------------------------------------------
52
HHSearch
50.56
17%
-2
- C2 -
-
2Q83
4
COTI_BACSU
A:
[19-296]
------------------------
L
T
E
L
A
E
N
V
L
---
Q
G
-----
W
D
V
-----
Q
---
A
E
K
I
D
--
V
I
Q
----
A
L
V
W
K
-
V
-----
H
---------
T
D
---------
S
G
A
----------
V
C
L
K
R
I
H
R
P
----------
E
K
K
---------
A
-
L
F
S
I
F
A
Q
-
D
Y
L
A
K
-
K
-
G
M
N
-
V
-
P
G
I
L
P
------
N
---------
K
K
G
SL
Y
S
K
H
----
G
------
S
---
F
L
F
----
V
V
Y
D
W
I
E
G
----
R
P
F
E
L
T
-------------------------------------
V
K
--
Q
D
L
E
---
F
I
M
K
-
G
L
A
D
F
H
-------
T
A
S
-----
V
G
Y
Q
--
P
-----
P
-----
N
---
G
--
V
P
---
I
F
T
----
K
L
G
R
--------------
W
P
N
H
Y
--------
T
K
R
C
K
Q
-------
M
E
T
W
K
L
M
A
E
A
E
K
-------
E
D
P
F
S
Q
L
Y
L
Q
E
-
I
------
D
G
F
I
----------
E
D
G
L
R
I
-----
K
D
R
L
L
Q
S
T
Y
V
P
W
T
E
----
Q
--
L
---
K
K
S
--
P
-----
N
L
C
H
Q
D
Y
G
T
G
N
T
L
L
G
E
N
----
E
Q
I
W
V
I
D
L
D
T
V
S
F
D
L
P
I
R
D
L
R
K
M
I
I
P
L
L
D
T
T
G
V
---------------
W
D
D
E
--
T
F
N
V
M
L
N
-
A
Y
E
S
--
R
A
---
P
----
L
T
------------
E
---
E
-
Q
------
K
---------------------------------------------------------------------------------------------------