@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : A8LBX6_FRASN: (2019-01-26 )
MSWDFETDPEFAQQLEWIDQFVRDEIEPVDLLVTNYGFDLSDPVRQALIPPLQQMVHERNLWACHLGPNLGGKGYGQVKLALMNEILGRSQCAPIVFGCQAPDSGNAEILAHYGSERLKETYLRPLVAGEVVSCYSMTEPEGGSDPTQFRTSAVPDGDEWVINGTKWYSSHSRFASFIIVLAVTDPDAEPHRRMSMFVVPADAPGLETIRNVALFGHERHDGGHGYLRYNNVRVPADHLLGKRGDGFVVSQTRLGGGRIHHAMRTVGLVRKALDMMCERVLSRYTQGERLADKQMVQEMLADSWTQLEQFRLLVLQTAWKIDKYDDYRKVRKDIAAVKATMPKVLNDVAGRALQLHGSLGTSDEMPFGDWIMESYRMGLADGATEIHKITVAKQLLRGRTPAPGLFPTGHLPALRAAAEAKFADRLAAVRGSHGSSGPSAAVAPSTAAETPVTDDAPRPDDMPEIADVRPGEELDWDRLVTYLSTALGVAAGAWSVKQFPNGSANLTYLVHVNDELSVVVRRPPLGTIAAGAHDMSREHRVLSRLPNAYPRAPRSLLVCEDPSIIGAPFDVMEYRPGVVVWRSIPEVLQVGDNVGHRIGLAVADALADLHTVDPASCDLADLGRPVGFLERQMAGWQKRWAAVASEAEAALMEEAATRLGRNVPTNPVHSLLHNDYQLTNVQFAAGDPDRVYSVFDWDMATLGDPLADLGSLLNYWPDPSDTAQSAGLYLPEQATIGLPTRAEMAERYAARSGFGLDNLGWYEAFAAYRVTVILQQLAARYQRGESTDPRMAERAQLVHPMAVRALDLLDHHGVK
Atome Classification :
(23 SA)
-----------------------....----------------.....10........----20........30.....-----.--..-40...----.....50----...---------------..-...60.....-.---------..70....---...--.80........90-...--......100.....--..110.......120.......130--.........140.-.......150..--.--...-.-160.......170-....--.....180....----.--..190.........200---------.......210.....-..220---..-----.....230.......240........250.......260.......270.......280.......290.......300.......310.......320.---.-----------...----------------..-330.......340.......350.......360.......370.-......380.......390.......400.......-410.......420.......430.......440.......450.......460.......----470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750......-.760.......770.......780.......790.......800.......810...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------MSWD----------------FET
D
P
E
F
A
Q
Q
L
E
W
I
D
----
Q
F
V
R
DEIEP
V
D
L
L
V
TNY-----G--FD-L
S
D
P
V
----
R
Q
A
L
I
P
P
----
L
Q
Q
---------------
M
V
-
H
ERN
L
W
A
C
HL-G---------PNLGGKGY---
G
Q
V
--
K
L
A
L
M
N
E
I
LGRS--QCA--
P
I
V
F
GCQAPDSG
N
A
--
E
I
L
A
H
Y
G
S
E
R
L
K
E
T
Y
L
R
P
L
VAGE----
V
V
S
C
Y
SMTEPE-G-GSDPT
Q
F
RTSAV--P--DGD-
E
-
W
V
I
NG
T
K
WYSS---H
S
R
F
--
A
S
F
I
I
V
L
A
V
TDP----D--AEP--H
R
R
M
S
M
F
V
V
PAD---------AP
G
L
E
T
I
R
N
V
A
LFGH-ERHDG---GH-----
G
Y
L
R
YN
N
V
RV
P
A
D
H
LLG-KRGD
G
F
V
V
S
Q
TRLGG
G
R
I
H
H
A
M
R
T
V
G
L
V
R
K
A
L
D
M
M
C
E
R
V
L
S
R
YTQGERL
A
D
K
Q
M
V
Q
E
M
L
A
D
S
W
T
Q
L
E
Q
F
R
L
L
V
L
Q
T
AWKIDK---
Y
-----------
D
D
Y
----------------
R
K
-
V
R
K
D
I
A
A
V
K
A
T
M
P
K
V
L
N
D
VAG
R
A
L
Q
L
HGSLGTSDEM
P
F
G
D
W
I
M
E
-
S
Y
RMGLADGA
T
E
I
H
K
I
T
V
A
K
Q
L
LRGRTPAPGLFPTG-
H
L
P
A
L
R
A
A
A
E
A
K
F
A
D
R
L
A
A
V
RGSHGSSGPSAAVAPSTAAETPVTDDAPRPDDMPEIADVR----PGEEL
D
W
D
R
L
V
T
Y
L
S
T
A
L
G
VAAGAW
S
V
KQFPNGSA
N
L
T
Y
L
V
HVND
E
L
S
V
V
V
RRPPLG
T
I
AAGAH
D
M
S
R
E
H
R
V
L
S
RLPNAYPRAP
R
S
L
L
V
CEDPSIIGAP
F
D
V
M
EYRP
G
V
V
V
W
R
S
I
P
E
V
L
Q
V
GDNVG
H
R
I
G
L
A
V
A
D
A
L
A
D
LHTVDPASC
D
L
A
D
LGR
P
V
G
F
L
E
R
Q
M
A
G
W
Q
K
R
W
A
A
V
A
S
E
A
E
A
A
L
M
E
E
A
A
T
RLGRNVP
T
N
P
V
H
S
L
L
HNDY
Q
L
T
N
V
Q
FAAGDPD
R
V
Y
S
V
FDW
D
M
A
TLG
D
P
L
A
D
L
G
S
L
L
NYWPDPSDTAQSAGLYLPEQATIGLP
T
R
A
E
M
A
E
R
Y
A
ARSGFGLDN-
L
G
W
Y
E
A
F
A
A
Y
R
V
T
V
I
L
Q
Q
L
A
A
R
Y
QRGEST
D
P
R
M
A
E
R
A
Q
L
V
H
P
M
A
V
R
A
L
D
L
L
D
HHGVK
81
Fugue
80.55
22%
20
- C2 -
-
2Z1Q
2
?
B:
[5-577]
------KKLWQKGGGWLLEVPE
R
V
Y
T
P
----------------
E
D
F
D
E
S
V
K
E
I
A
R
T
T
R
----
T
F
V
E
R
E
V
L
P
L
L
E
R
M
----------------
E
H
G
----
E
L
E
L
N
V
P
----
L
M
R
---------------
K
A
-
G
E
L
G
L
L
A
I
D
V
-
P
---------
E
E
Y
G
G
L
D
L
---
P
K
V
--
I
S
T
V
V
A
E
E
L
S
G
S
--
G
G
F
--
S
V
T
Y
G
A
H
T
S
I
G
--
T
--
L
P
L
V
Y
F
G
T
E
E
Q
K
R
K
Y
L
P
K
L
A
S
G
E
----
W
I
A
A
Y
C
L
T
E
P
G
-
S
-
G
S
D
A
L
A
A
K
T
R
A
T
L
S
E
--
D
G
K
-
H
-
Y
I
L
N
G
V
K
Q
W
I
S
---
N
A
G
F
--
A
H
L
F
T
V
F
A
K
V
D
-------------
G
E
H
F
T
A
F
L
V
E
R
D
---------
T
P
G
L
S
F
G
P
E
E
K
K
M
G
---
I
K
A
S
---
S
T
-----
R
Q
V
I
L
E
D
V
K
V
P
V
E
N
V
L
G
-
E
I
G
K
G
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
S
A
Q
Y
A
T
Q
R
V
Q
F
G
R
P
I
G
R
F
G
L
I
Q
Q
K
L
G
E
M
A
S
R
I
Y
A
A
E
S
A
V
Y
R
T
V
G
L
I
D
E
---
A
L
LGKKG
P
E
A
V
M
A
G
I
----------------
E
E
-
Y
A
V
E
A
S
I
I
K
V
L
G
S
E
V
L
D
Y
V
V
D
E
G
V
Q
I
H
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
-
A
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
L
I
P
G
M
L
L
R
--
R
A
E
P
E
D
L
E
L
H
-
Q
V
Q
N
L
K
K
L
A
L
M
V
A
G
L
A
V
Q
K
Y
---------------------------------------------
G
Q
G
V
E
E
E
----------------------------------------------------------------------------------------------------------------------
Q
E
V
L
G
A
V
A
D
I
L
I
D
A
Y
A
A
E
S
A
L
L
R
A
R
R
L
G
-----------
G
L
A
P
V
L
A
R
I
Y
L
A
Q
A
L
D
R
A
Q
A
G
A
L
S
V
L
P
R
L
V
E
G
---------------------------------
D
E
A
R
V
V
Y
S
A
A
R
R
L
T
K
R
E
P
G
D
-----------------
L
V
A
L
R
R
Q
A
A
E
A
V
L
E
A
G
G
Y
P
I
P
R
----------------------------------------------------------
1
PsiBlast_PDB
77.69
36%
0
- C2 -
-
4HR3
1
?
A:
[7-406]
-------------------------------------------
F
A
P
S
A
R
A
A
E
L
I
A
A
V
R
----
E
F
I
D
A
E
V
M
P
V
E
R
A
V
L
A
H
H
D
E
L
L
G
--
A
R
-
A
G
T
T
A
----
E
L
W
H
V
P
P
E
L
D
S
L
K
A
---------------
K
A
-
R
A
A
G
L
W
N
L
F
L
P
D
---------
P
E
L
G
G
-
G
L
---
S
N
S
--
E
Y
A
P
L
A
E
Q
M
G
R
S
--
L
F
A
--
P
T
V
F
N
C
N
A
P
D
S
G
N
M
--
E
V
L
H
R
Y
G
S
Q
E
Q
K
E
V
W
L
E
P
L
L
E
G
D
----
I
R
S
A
F
C
M
T
E
P
D
V
A
-
S
S
D
A
T
N
M
A
A
T
A
V
--
V
--
E
G
D
-
E
-
V
V
I
N
G
R
K
W
W
S
T
---
G
V
G
H
PD
C
K
V
I
I
F
M
G
L
T
D
P
----
N
--
A
H
R
--
Y
A
R
H
S
M
V
L
V
P
M
D
---------
T
P
G
I
T
V
E
R
M
L
P
T
M
G
F
-
Y
D
E
P
G
---
G
H
-----
G
V
V
S
F
D
N
V
R
L
P
A
D
A
F
I
A
-
G
P
G
K
G
F
E
I
A
Q
G
R
L
G
P
G
R
V
H
H
A
M
R
L
I
G
L
A
E
V
A
L
E
H
A
C
R
R
G
L
D
R
T
A
F
G
K
P
L
V
N
L
G
G
N
R
E
R
I
A
D
A
R
I
A
I
N
Q
T
R
L
L
V
L
H
A
A
W
L
L
D
T
---
V
-----------
G
I
M
----------------
G
A
-
L
S
A
-
V
S
E
I
K
V
A
A
P
N
M
A
Q
Q
V
I
D
M
A
I
Q
I
H
G
G
G
G
L
S
N
D
F
P
L
A
A
A
W
V
N
-
A
R
A
L
R
L
A
D
G
P
D
E
V
H
R
G
V
V
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
HHSearch
76.35
34%
-11
- C2 -
-
2WBI
2
ACD11_HUMAN
B:
[22-422]
--------------------------------------------
V
Q
T
R
K
G
Q
E
V
L
I
K
V
K
----
H
F
M
K
Q
H
I
L
P
A
E
K
E
V
T
E
F
-----
Y
V
Q
N
E
N
S
V
D
K
W
----
G
K
P
L
V
I
D
----
K
L
K
---------------
E
M
A
K
V
E
G
L
W
N
L
F
L
-
P
---------
A
V
S
G
L
------
S
H
V
--
D
Y
A
L
I
A
E
E
T
G
K
C
F
F
A
P
D
V
F
N
C
Q
A
-
P
D
---
T
G
N
M
--
E
V
L
H
L
Y
G
S
E
E
Q
K
K
Q
W
L
E
P
L
L
Q
G
N
----
I
T
S
C
F
C
M
T
E
P
D
-
V
A
S
S
D
A
T
N
I
E
C
S
I
Q
--
R
--
D
E
D
-
S
-
Y
V
I
N
G
K
K
W
W
S
S
---
G
A
G
N
PK
C
K
I
A
I
V
L
G
R
T
Q
N
----
T
S--------
Q
H
S
M
I
L
V
P
M
N
---------
T
P
G
V
K
I
I
R
P
L
S
V
F
G
Y
-
T
--
D
N
FHG
G
H
-----
F
E
I
H
F
N
Q
V
R
V
P
A
T
N
L
I
L
-
G
E
G
R
G
F
E
I
S
Q
G
R
L
G
P
G
R
I
H
H
C
M
R
T
V
G
L
A
E
R
A
L
Q
I
M
C
E
R
A
T
Q
R
I
A
F
K
K
K
L
Y
A
H
E
V
V
A
H
W
I
A
E
S
R
I
A
I
E
K
I
R
L
L
T
L
K
A
A
H
S
M
D
T
---
L
-----------
G
S
A
-----------------
G
-
A
K
K
E
I
A
M
I
K
V
A
A
P
R
A
V
S
K
I
V
D
W
A
I
Q
V
C
G
G
A
G
V
S
Q
D
Y
P
L
-
A
N
M
Y
A
I
T
R
V
L
R
L
A
D
G
P
D
E
V
H
L
S
A
I
A
T
M
E
L
R
D
Q
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
74.69
36%
5
- C2 -
-
2WBI
2
ACD11_HUMAN
B:
[34-418]
--------------------------------------------------------
V
K
----
H
F
M
K
Q
H
I
L
P
A
E
K
E
V
T
E
F
-----
Y
--
V
Q
-
N
E
N
S
V
DKWG
K
P
L
V
I
D
K
----
L
K
E
---------------
M
A
-
K
V
E
G
L
W
N
L
F
L
-----------
P
A
V
S
G
--
L
---
S
H
V
--
D
Y
A
L
I
A
E
E
T
G
K
C
--
F
F
A
--
P
D
V
F
N
C
Q
A
P
D
T
G
N
M
--
E
V
L
H
L
Y
G
S
E
E
Q
K
K
Q
W
L
E
P
L
L
Q
G
N
----
I
T
S
C
F
C
M
T
E
P
D
V
A
-
S
S
D
A
T
N
I
E
C
S
I
Q
--
R
--
D
E
D
-
S
-
Y
V
I
N
G
K
K
W
W
S
S
GAG
N
P
K
C
--
K
I
A
I
V
L
G
R
T
Q
N
T
----
S
---------
Q
H
S
M
I
L
V
P
M
N
---------
T
P
G
V
K
I
I
R
P
L
S
V
F
G
Y
T
D
N
F
H
G
---
G
H
-----
F
E
I
H
F
N
Q
V
R
V
P
A
T
N
L
I
L
-
G
E
G
R
G
F
E
I
S
Q
G
R
L
G
P
G
R
I
H
H
C
M
R
T
V
G
L
A
E
R
A
L
Q
I
M
C
E
R
A
T
Q
R
I
A
F
K
K
K
L
Y
A
H
E
V
V
A
H
W
I
A
E
S
R
I
A
I
E
K
I
R
L
L
T
L
K
A
A
H
S
M
D
T
---
L
-----------
G
S
-----------------
A
G
-
A
K
K
E
I
A
M
I
K
V
A
A
P
R
A
V
S
K
I
V
D
W
A
I
Q
V
C
G
G
A
G
V
S
Q
D
Y
P
L
A
N
M
Y
A
I
-
T
R
V
L
R
L
A
D
G
P
D
E
V
H
L
S
A
I
A
T
M
E
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.95
35%
6
- C2 -
-
2WBI
2
ACD11_HUMAN
A:
[34-418]
--------------------------------------------------------
V
K
----
H
F
M
K
Q
H
I
L
P
A
E
K
E
V
T
E
-----------------KWG-
K
P
L
V
I
D
K
----
L
K
E
---------------
M
A
-
K
V
E
G
L
W
N
L
F
L
-----------
P
A
V
S
G
--
L
---
S
H
V
--
D
Y
A
L
I
A
E
E
T
G
K
C
--
F
F
A
--
P
D
V
F
N
C
Q
A
P
D
T
G
N
M
--
E
V
L
H
L
Y
G
S
E
E
Q
K
K
Q
W
L
E
P
L
L
Q
G
N
----
I
T
S
C
F
C
M
T
E
P
D
V
A
-
S
S
D
A
T
N
I
E
C
S
I
Q
--
R
--
D
E
D
-
S
-
Y
V
I
N
G
K
K
W
W
S
S
GAG
N
P
K
C
--
K
I
A
I
V
L
G
R
T
Q
N
T
----
S
--
L
S
R
--
H
K
Q
H
S
M
I
L
V
P
M
N
---------
T
P
G
V
K
I
I
R
P
L
S
V
F
G
Y
T
D
N
F
H
G
---
G
H
-----
F
E
I
H
F
N
Q
V
R
V
P
A
T
N
L
I
L
-
G
E
G
R
G
F
E
I
S
Q
G
R
L
G
P
G
R
I
H
H
C
M
R
T
V
G
L
A
E
R
A
L
Q
I
M
C
E
R
A
T
Q
R
I
A
F
K
K
K
L
Y
A
H
E
V
V
A
H
W
I
A
E
S
R
I
A
I
E
K
I
R
L
L
T
L
K
A
A
H
S
M
D
T
---
L
-----------
G
S
-----------------
A
G
-
A
K
K
E
I
A
M
I
K
V
A
A
P
R
A
V
S
K
I
V
D
W
A
I
Q
V
C
G
G
A
G
V
S
Q
D
Y
P
L
A
N
M
Y
A
I
-
T
R
V
L
R
L
A
D
G
P
D
E
V
H
L
S
A
I
A
T
M
E
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Fugue
72.72
19%
16
- C2 -
-
2UXW
4
ACADV_HUMAN
A:
[21-607]
QSMS
F
A
V
G
M
F
K
GQLTTDQVFPYP
S
V
L
N
----------------
E
E
Q
T
Q
F
L
K
E
L
V
E
P
V
S
----
R
F
F
E
E
V
N
D
P
A
K
N
D
A
L
E
-----------------------
M
V
E
E
T
----
T
W
Q
---------------
G
L
-
K
E
L
G
A
F
G
L
Q
V
-
P
---------
S
E
L
G
G
V
G
L
---
C
N
T
--
Q
Y
A
R
L
V
E
I
V
G
M
H
---
D
L
--
G
V
G
I
T
L
G
A
H
Q
S
I
G
F
--
K
G
I
L
L
F
G
T
K
A
Q
K
E
K
Y
L
P
K
L
A
S
G
E
----
T
V
A
A
F
C
L
T
E
P
S
-
S
-
G
S
D
A
A
S
I
R
T
S
A
V
P
S
P
--
C
G
K
-
Y
-
Y
T
L
N
G
S
K
L
W
I
S
---
N
G
G
L
--
A
D
I
F
T
V
F
A
K
T
P
V
T
D
PA
T
--
G
A
V
--
K
E
K
I
T
A
F
V
V
E
R
G
---------
F
G
G
I
T
H
G
P
P
E
K
K
M
G
I
-
K
A
S
N
-----
T
-----
A
E
V
F
F
D
G
V
R
V
P
S
E
N
V
L
G
-
E
V
G
S
G
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
V
M
L
Q
Y
V
T
E
S
M
A
Y
M
V
S
A
N
M
D
Q
----------------
G
A
----------------
T
D
-
F
Q
I
E
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
-
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
F
V
A
L
Q
G
C
M
D
K
G
K
E
L
S
G
L
G
S
-------------------------------------------
A
L
K
N
P
F
G
S
G
L
S
L
S
G
L
V
H
---------------------------------------------------------------------
P
E
L
S
R
S
G
E
L
A
V
R
A
L
E
Q
F
A
T
V
V
E
A
K
L
I
K
H
K
K
G
I
V
N
E
----------------------------
Q
F
L
L
Q
R
L
A
D
G
A
I
D
L
Y
A
M
V
V
V
L
S
R
A
S
R
S
L
S
E
G
H
P
T
A
Q
H
E
K
M
L
C
D
T
W
C
I
E
A
A
A
R
I
R
E
G
M
A
A
L
Q
S
-------------------------------------------------------------------------
D
P
W
Q
Q
E
L
Y
R
N
F
K
S
I
S
K
A
L
V
E
R
G
G
V
V
T
S
N
P
L
G
F
------------------------------------------------------
101
HHSearch
68.70
24%
-18
- C2 -
-
2JIF
6
ACDSB_HUMAN
A:
[24-403]
------------------------
A
P
L
----------------
Q
T
F
T
D
E
E
M
M
I
K
S
S
V
K
----
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
E
N
---------------------
S
K
M
E
K
S
----
V
I
Q
---------------
G
L
-
F
Q
Q
G
L
M
G
I
E
V
-
D
---------
P
E
Y
G
G
T
G
A
---
S
F
L
--
S
T
V
L
V
I
E
E
L
A
K
V
D
A
S
V
A
--
V
F
C
E
I
Q
N
---
T
L
I
N
--
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
-
E
----
K
V
G
S
F
C
L
S
E
A
G
-
A
-
G
S
D
S
F
A
L
K
T
R
A
D
--
K
--
E
G
D
-
Y
-
Y
V
L
N
G
S
K
M
W
I
S
---
S
A
E
H
--
A
G
L
F
L
V
M
A
N
V
D
P
-------
T
I
G
--
Y
K
G
I
T
S
F
L
V
D
R
D
---------
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
-
R
--
A
S
---
S
T
-----
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
-
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
---
G
-----------
K
-------------------
P
-
F
I
K
E
A
S
M
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
-
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
D
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
68.49
28%
-31
- C2 -
-
1UDY
5
ACADM_PIG
A:
[29-389]
--------------------------------------------------------------
K
F
A
R
E
E
I
I
P
V
---
A
A
E
Y
-----
D
--
R
T
-
G
E
Y
P
V
----------
P
----
L
L
K
---------------
R
A
-
W
E
L
G
L
M
N
T
H
I
-
P
---------
E
S
F
G
G
L
G
L
---
G
I
I
--
D
S
C
L
I
T
E
E
L
A
Y
G
---
C
T
--
G
V
Q
T
A
I
E
A
N
T
L
G
Q
V
--
P
L
I
I
G
-
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
----
L
M
C
A
Y
C
V
T
E
P
G
-
A
-
G
S
D
V
A
G
I
K
T
K
A
E
--
K
--
K
G
D
-
E
-
Y
I
I
N
G
Q
K
M
W
I
T
---
N
G
G
K
--
A
N
W
Y
F
L
L
A
R
S
D
P
----
D
PK
A
P
A
--
S
K
A
F
T
G
F
I
V
E
A
D
---------
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
-
R
C
S
D
T
---
R
G
-------
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
-
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
-----------------
D
S
G
----------------
R
R
-
N
T
Y
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
-
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
68.19
29%
-75
- C2 -
-
2VIG
5
ACADS_HUMAN
A:
[51-384]
---------------------------------------------------------------------------------------------------------------------------------------
L
L
A
M
D
V
-
P
---------
E
E
L
G
G
A
G
L
---
D
Y
L
--
A
Y
A
I
A
M
E
E
I
S
R
G
---
C
A
--
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
--
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
----
K
I
G
C
F
A
L
S
E
P
G
-
N
-
G
S
D
A
G
A
A
S
T
T
A
R
--
A
--
E
G
D
-
S
-
W
V
L
N
G
T
K
A
W
I
T
---
N
A
W
E
--
A
S
A
A
V
V
F
A
S
T
D
-----
R
--
A
L
Q
--
N
K
S
I
S
A
F
L
V
P
M
P
---------
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
-
R
G
S
S
T
---
A
N
-------
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
-
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
----
W
R
A
A
M
---
L
-----------
K
D
N
----------------
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
-
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
R
S
Y
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
67.88
28%
-28
- C2 -
-
3MDD
2
ACADM_PIG
A:
[19-379]
--------------------------------------------------------------
K
F
A
R
E
E
I
I
P
V
---
A
A
E
Y
-----
D
--
R
T
-
G
E
Y
P
V
----------
P
----
L
L
K
---------------
R
A
-
W
E
L
G
L
M
N
T
H
I
-
P
---------
E
S
F
G
G
L
G
L
---
G
I
I
--
D
S
C
L
I
T
E
E
L
A
Y
G
---
C
T
--
G
V
Q
T
A
I
E
A
N
T
L
G
Q
V
--
P
L
I
I
G
-
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
----
L
M
C
A
Y
C
V
T
E
P
G
-
A
-
G
S
D
V
A
G
I
K
T
K
A
E
--
K
--
K
G
D
-
E
-
Y
I
I
N
G
Q
K
M
W
I
T
---
N
G
G
K
--
A
N
W
Y
F
L
L
A
R
S
D
P
----
D
PK
A
P
A
--
S
K
A
F
T
G
F
I
V
E
A
D
---------
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
-
R
C
S
D
T
---
R
G
-------
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
-
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
-----------------
D
S
G
----------------
R
R
-
N
T
Y
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
-
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
67.82
28%
-28
- C2 -
-
3MDE
3
ACADM_PIG
A:
[19-379]
--------------------------------------------------------------
K
F
A
R
E
E
I
I
P
V
---
A
A
E
Y
-----
D
--
R
T
-
G
E
Y
P
V
----------
P
----
L
L
K
---------------
R
A
-
W
E
L
G
L
M
N
T
H
I
-
P
---------
E
S
F
G
G
L
G
L
---
G
I
I
--
D
S
C
L
I
T
E
E
L
A
Y
G
---
C
T
--
G
V
Q
T
A
I
E
A
N
T
L
G
Q
V
--
P
L
I
I
G
-
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
----
L
M
C
A
Y
C
V
T
E
P
G
-
A
-
G
S
D
V
A
G
I
K
T
K
A
E
--
K
--
K
G
D
-
E
-
Y
I
I
N
G
Q
K
M
W
I
T
---
N
G
G
K
--
A
N
W
Y
F
L
L
A
R
S
D
P
----
D
PK
A
P
A
--
S
K
A
F
T
G
F
I
V
E
A
D
---------
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
-
R
C
S
D
T
---
R
G
-------
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
-
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
-----------------
D
S
G
----------------
R
R
-
N
T
Y
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
-
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
SP3
67.81
12%
-84
- C2 -
-
1JQI
4
ACADS_RAT
A:
[4-387]
-----------------------
V
Y
Q
S
----------------
V
E
L
P
E
T
H
Q
M
L
R
Q
T
C
R
----
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
E
-----
H
--
L
--------------
F
P
T
S
----
Q
V
K
---------------
K
M
-
G
E
L
G
L
L
A
M
D
V
-
P
---------
E
E
L
S
G
A
G
L
---
D
Y
L
--
A
Y
S
I
A
L
E
E
I
S
R
G
--
C
-
A
--
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
--
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
----
K
I
G
C
F
A
L
S
E
P
G
-
N
-
G
S
D
A
G
A
A
S
T
T
A
R
--
E
--
E
G
D
-
S
-
W
V
L
N
G
T
K
A
W
I
T
---
N
S
W
E
--
A
S
A
T
V
V
F
A
S
T
D
R
----
S
---
R
Q
--
N
K
G
I
S
A
F
L
V
P
M
P
---------
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
-
R
A
S
S
T
----------
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
-
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
-----------------
K
----------------
K
P
-
F
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
-
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
R
S
Y
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Fugue
67.47
26%
-4
- C2 -
-
1BUC
3
ACDS_MEGEL
A:
[1-383]
-------------------------
M
D
----------------
F
N
L
T
D
I
Q
Q
D
F
L
K
L
A
H
----
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
H
K
-----
G
------
I
Y
D
------
K
E
L
I
D
E
----
L
L
S
---------------
L
-----
G
I
T
G
A
Y
F
-
E
---------
E
K
Y
G
G
S
G
D
DGG
D
V
L
--
S
Y
I
L
A
V
E
E
L
A
K
Y
---
D
A
--
G
V
A
I
T
L
S
A
T
V
S
L
C
A
--
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
----
K
L
G
A
F
G
L
T
E
P
N
-
A
-
G
T
D
A
S
G
Q
Q
T
I
A
T
--
K
--
N
D
D
G
T
-
Y
T
L
N
G
S
K
I
F
I
T
---
N
G
G
A
--
A
D
I
Y
I
V
F
A
M
T
D
K
----
S
-----KG
N
H
G
I
T
A
F
I
L
E
D
G
---------
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
---
H
T
S
---
Q
T
-----
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
-
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
---
G
-----------
K
P
F
--------------------
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
-
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
67.34
24%
-21
- C2 -
-
4L1F
5
?
A:
[1-380]
-------------------------
M
D
----------------
F
N
L
T
E
D
Q
Q
M
I
K
D
M
A
A
----
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
---------------------
H
I
W
D
R
K
----
L
I
D
---------------
K
M
-
G
E
A
G
F
C
G
I
C
F
-
P
---------
E
E
Y
G
G
M
G
L
---
D
V
L
--
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
T
G
--
I
T
L
S
A
N
V
---
S
L
C
A
--
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
----
H
V
G
A
F
G
L
T
E
P
S
-
A
-
G
T
D
A
S
A
Q
Q
T
T
A
V
--
L
--
K
G
D
-
K
-
Y
I
L
N
G
S
K
I
F
I
T
---
N
G
K
E
--
A
D
T
Y
V
V
F
A
M
T
D
K
-------
S
Q
G
--
V
H
G
I
S
A
F
I
L
E
K
G
---------
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
-
H
--
T
S
---
I
T
-----
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
-
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
---
G
-----------
K
-------------------
P
-
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
-
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
R
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
67.23
24%
-15
- C2 -
-
3OWA
6
?
C:
[30-428]
--------------------------
P
----------------
E
D
F
S
S
E
H
K
M
I
A
K
T
T
E
----
D
F
I
V
N
E
V
L
P
E
L
E
Y
L
E
Q
H
--------------------
E
F
D
R
S
V
R
----
L
L
K
---------------
E
A
-
G
E
L
G
L
L
G
A
D
V
-
P
---------
E
E
Y
G
G
I
G
L
---
D
K
V
--
S
S
A
L
I
A
E
K
F
S
R
A
G
-
G
F
A
--
I
T
H
G
A
H
V
---
G
I
G
S
--
L
P
I
V
L
F
G
N
E
E
Q
K
K
K
Y
L
P
L
L
A
T
G
E
----
K
L
A
A
Y
A
L
T
E
P
G
-
S
-
G
S
D
A
L
G
A
K
T
T
A
R
--
L
N
A
E
G
T
-
H
-
Y
V
L
N
G
E
K
Q
W
I
T
---
N
S
A
F
--
A
D
V
F
I
V
Y
A
K
I
D
G
-------------
E
H
F
S
A
F
I
V
E
K
D
---------
Y
A
G
V
S
T
S
P
E
E
K
K
M
G
I
-
K
--
C
S
---
S
T
-----
R
T
L
I
L
E
D
A
L
V
P
K
E
N
L
L
G
-
E
I
G
K
G
H
I
I
A
F
N
I
L
N
I
G
R
Y
K
L
G
V
G
T
V
G
S
A
K
R
A
V
E
I
S
A
Q
Y
A
N
Q
R
Q
Q
F
K
Q
P
I
A
R
F
P
L
I
Q
E
K
L
A
N
M
A
A
K
T
Y
A
A
E
S
S
V
Y
R
T
V
G
L
F
E
S
---
R
-----------
M
S
T
LS
E
E
E
V
K
D
G
K
A
V
A
A
S
I
A
E
-
Y
A
I
E
C
S
L
N
K
V
F
G
S
E
V
L
D
Y
T
V
D
E
G
V
Q
I
H
G
G
Y
G
F
M
A
E
Y
E
I
-
E
R
M
Y
R
D
S
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
I
V
P
G
T
F
L
R
K
A
M
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
67.16
27%
-13
- C2 -
-
3PFD
-
?
C:
[23-393]
-------------------------------------------------
H
I
A
L
R
E
A
I
R
----
A
L
A
E
K
E
I
A
P
Y
A
A
E
V
D
E
K
---------------------
A
R
F
P
E
E
----
A
L
A
---------------
A
L
-
N
S
S
G
F
S
A
I
H
V
-
P
---------
E
E
Y
G
G
Q
G
A
---
D
S
V
--
A
T
C
I
V
I
E
E
V
A
R
V
DC
S
A
S
--
L
I
P
A
V
N
----
K
L
G
T
--
M
G
L
I
L
R
G
S
E
E
L
K
K
Q
V
L
P
A
V
A
S
G
E
----
A
M
A
S
Y
A
L
S
E
R
E
-
A
-
G
S
D
A
A
S
M
R
T
R
A
V
--
A
--
D
G
D
-
D
-
W
I
L
N
G
S
K
C
W
I
T
---
N
G
G
K
--
S
T
W
Y
T
V
M
A
V
T
D
P
-------
D
K
G
--
A
N
G
I
S
A
F
M
V
H
K
D
---------
D
E
G
F
T
V
G
P
K
E
R
K
L
G
I
-
K
--
G
S
---
P
T
-----
T
E
L
Y
F
E
N
C
R
I
P
G
D
R
I
I
G
-
E
P
G
T
G
F
K
T
A
L
A
T
L
D
H
T
R
P
T
I
G
A
Q
A
V
G
I
A
Q
G
A
L
D
A
A
I
A
Y
T
K
E
R
K
Q
F
G
R
P
V
S
D
N
Q
G
V
Q
F
M
L
A
D
M
A
M
K
I
E
A
A
R
L
M
V
Y
S
A
A
A
R
A
E
R
---
G
-------------------------------
D
-
L
G
F
I
S
A
A
S
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
L
F
G
G
Y
G
Y
T
Q
D
F
P
V
-
E
R
M
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
Q
I
Q
R
V
V
M
S
R
A
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
67.02
26%
-27
- C2 -
-
5JSC
3
?
A:
[22-400]
-------------------------
A
W
----------------
P
F
F
E
P
R
H
R
E
L
A
A
G
I
E
----
A
W
C
R
A
N
L
A
------
E
D
V
---------------------
D
A
T
C
R
R
----
L
V
R
---------------
E
L
-
G
A
A
G
W
L
K
Y
G
V
-
G
G--------
V
A
Y
G
G
H
G
D
---
T
I
D
T
R
A
V
C
L
L
R
E
T
L
A
K
H
S-
G
L
A
--
D
F
A
L
A
M
Q
---
G
L
G
S
--
G
A
I
S
L
G
G
T
H
E
Q
K
T
R
Y
L
P
R
V
A
N
G
T
----
A
I
A
A
F
A
L
S
E
P
E
-
A
-
G
S
D
V
A
A
M
T
L
S
A
R
--
E
--
D
G
D
-
A
-
Y
V
L
D
G
D
K
T
W
I
S
---
N
G
G
I
--
A
D
F
Y
V
V
F
A
R
T
G
E
-------
A
P
G
--
A
R
G
I
S
A
F
V
V
D
A
D
---------
T
P
G
L
E
I
A
E
R
I
D
V
I
A
P
-----
H
---
P
L
-----
A
R
L
H
F
A
G
A
R
V
P
R
S
Q
M
L
G
-
A
P
G
E
G
F
K
L
A
M
R
T
L
D
I
F
R
T
S
V
A
A
A
S
L
G
F
A
R
H
A
M
A
E
G
V
A
R
A
A
S
R
K
M
F
G
Q
T
L
G
D
F
Q
L
T
Q
A
K
L
A
Q
M
A
L
T
I
D
S
S
A
L
L
V
Y
R
A
A
W
L
R
D
Q
---
G
-----------
E
-------------------
N
-
V
T
R
E
A
A
M
A
K
W
H
A
S
E
G
A
Q
Q
V
I
D
A
A
V
Q
L
Y
G
G
M
G
V
Q
S
G
T
A
V
-
E
M
L
Y
R
E
I
R
A
L
R
I
Y
E
G
A
T
E
V
Q
Q
L
I
V
G
R
D
L
L
K
A
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
67.02
27%
16
- C2 -
-
1EGD
3
ACADM_HUMAN
A:
[15-389]
------------------------------------------------
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
---
A
A
E
Y
-----
D
--
K
T
-
G
E
Y
P
V
----------
P
----
L
I
R
---------------
R
A
-
W
E
L
G
L
M
N
T
H
I
-
P
---------
E
N
C
G
G
L
G
L
---
G
T
F
--
D
A
C
L
I
S
E
E
L
A
Y
G
---
C
T
--
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
--
P
I
I
I
A
-
G
N
D
Q
Q
K
K
K
Y
L
G
R
M
T
E
E
P
----
L
M
C
A
Y
C
V
T
E
P
G
-
A
-
G
S
D
V
A
G
I
K
T
K
A
E
--
K
--
K
G
D
-
E
-
Y
I
I
N
G
Q
K
M
W
I
T
---
N
G
G
K
--
A
N
W
Y
F
L
L
A
R
S
D
P
----
D
PK
A
P
A
--
N
K
A
F
T
G
F
I
V
E
A
D
---------
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
-
R
C
S
D
T
---
R
G
-------
I
V
F
E
D
V
K
V
P
K
E
N
V
L
I
-
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
E
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
-----------------
D
S
G
----------------
R
R
-
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
-
A
K
I
Y
Q
I
Y
G
G
T
S
Q
I
Q
R
L
I
V
A
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
66.80
25%
-24
- C2 -
-
2PG0
2
?
B:
[8-383]
-------------------------------------------
R
Y
L
R
E
E
H
H
M
F
R
A
A
F
R
----
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
R
---------------------
G
I
I
P
R
S
----
F
W
A
---------------
K
M
-
G
E
N
G
F
L
C
P
W
V
-
D
---------
E
K
Y
G
G
L
N
A
---
D
F
A
--
Y
S
V
V
I
N
E
E
L
E
K
V
GS
S
L
V
--
G
-
I
G
L
H
N
---
D
I
V
T
--
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
----
L
I
T
A
I
A
M
T
E
P
G
-
A
-
G
S
D
L
A
N
I
S
T
T
A
V
--
K
--
D
G
D
-
Y
-
Y
I
V
N
G
Q
K
T
F
I
T
---
N
G
I
H
--
A
D
L
I
V
V
A
C
K
T
D
P
----
Q
A-
K
P
P
--
H
R
G
I
S
L
L
V
V
E
R
D
---------
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
-
H
--
A
Q
---
D
T
-----
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
-
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
E
E
H
M
A
---
G
-----------
K
-------------------
Q
-
I
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
-
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
66.69
28%
19
- C2 -
-
2A1T
3
ACADM_HUMAN
A:
[40-414]
------------------------------------------------
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
---
A
A
E
Y
-----
D
--
K
T
-
G
E
Y
P
V
----------
P
----
L
I
R
---------------
R
A
-
W
E
L
G
L
M
N
T
H
I
-
P
---------
E
N
C
G
G
L
G
L
---
G
T
F
--
D
A
C
L
I
S
E
E
L
A
Y
G
---
C
T
--
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
--
P
I
I
I
A
-
G
N
D
Q
Q
K
K
K
Y
L
G
R
M
T
E
E
P
----
L
M
C
A
Y
C
V
T
E
P
G
-
A
-
G
S
D
V
A
G
I
K
T
K
A
E
--
K
--
K
G
D
-
E
-
Y
I
I
N
G
Q
K
M
W
I
T
---
N
G
G
K
--
A
N
W
Y
F
L
L
A
R
S
D
P
----
D
PK
A
P
A
--
N
K
A
F
T
G
F
I
V
E
A
D
---------
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
-
R
C
S
D
----
T
R
-----
G
I
V
-
F
E
D
V
K
V
P
K
E
N
V
L
I
-
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
-----------------
D
S
G
----------------
R
R
-
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
-
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
HHSearch
66.13
25%
-19
- C2 -
-
6ES9
3
?
A:
[166-551]
--------------------------------------------
G
L
D
E
D
L
E
M
I
R
D
Q
F
R
----
R
Y
A
E
E
R
V
I
P
N
A
H
E
W
H
L
K
--------------------
D
Q
L
I
P
M
E
----
I
I
E
---------------
E
L
-
A
E
L
G
V
F
G
L
T
I
-
P
---------
E
E
F
G
G
L
G
L
---
S
K
A
--
S
M
V
V
V
T
E
E
L
S
R
G
Y
I
G
V
G
--
S
L
G
T
-
R
S
---
E
I
A
A
--
E
L
I
L
C
G
G
T
E
A
Q
K
A
K
W
L
P
G
L
A
S
G
E
----
I
L
S
T
A
V
F
T
E
P
N
-
T
-
G
S
D
L
G
S
L
R
T
R
A
V
--
R
--
D
G
E
-
D
-
W
V
V
T
G
N
K
T
W
I
T
---
H
A
Q
R
--
T
H
V
M
T
L
L
A
R
T
D
P
----
E
--
T
T
D
--
W
R
G
L
S
M
F
L
A
E
K
E
P
G
T
DDDPFP
T
P
G
M
T
G
-
G
E
I
E
V
L
G
Y
-
R
--
G
M
---
K
E
-----
Y
E
L
G
F
D
G
F
R
I
K
G
E
N
L
L
G
G
E
P
G
R
G
F
K
Q
L
M
E
T
F
E
S
A
R
I
Q
T
A
A
R
A
V
G
V
A
Q
S
A
A
E
I
G
M
R
Y
A
V
D
R
K
Q
F
G
K
S
L
I
E
F
P
R
V
A
D
K
L
A
M
M
A
V
E
I
M
I
A
R
Q
L
T
Y
F
S
A
W
E
K
D
H
---
G
-----------
R
-------------------
R
-
C
D
L
E
A
G
M
A
K
L
L
G
A
R
V
A
W
A
A
A
D
N
A
L
Q
I
H
G
G
N
G
F
A
L
E
Y
A
I
-
S
R
V
L
C
D
A
R
I
L
N
I
F
E
G
A
A
E
I
Q
A
Q
V
I
A
R
R
L
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
66.05
25%
-24
- C2 -
-
2PG0
2
?
A:
[6-383]
-------------------------
T
A
----------------
R
Y
L
R
E
E
H
H
M
F
R
A
A
F
R
----
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
R
---------------------
G
I
I
P
R
S
----
F
W
A
---------------
K
M
-
G
E
N
G
F
L
C
P
W
V
-
D
---------
E
K
Y
G
G
L
N
A
---
D
F
A
--
Y
S
V
V
I
N
E
E
L
E
K
V
GS
S
L
V
--
G
-
I
G
L
H
N
---
D
I
V
T
--
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
----
L
I
T
A
I
A
M
T
E
P
G
-
A
-
G
S
D
L
A
N
I
S
T
T
A
V
--
K
--
D
G
D
-
Y
-
Y
I
V
N
G
Q
K
T
F
I
T
---
N
G
I
H
--
A
D
L
I
V
V
A
C
K
T
D
P
----
Q
A-
K
P
P
--
H
R
G
I
S
L
L
V
V
E
R
D
---------
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
-
H
--
A
Q
---
D
T
-----
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
-
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
E
E
H
M
A
---
G
-----------
K
-------------------
Q
-
I
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
-
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Fugue
58.20
16%
-9
- C2 -
-
3DJL
1
AIDB_ECOLI
A:
[3-540]
-------------------------
W
Q
T
H
T
V
F
NQPIPLNNSNL
Y
L
S
D
G
A
L
C
E
A
V
T
R
E
G
A---
G
W
D
S
D
F
L
A
S
I
G
Q
Q
L
G
T
A
-----
E
--
S
L
-
E
L
G
R
L
----
A
N
V
N
P
P
E
----
L
L
R
YDAQGRRLD
D
V
R
F
H
P
A
W
-
H
L
L
M
Q
A
L
C
T
N
-
R
VHNLAWEED
A
R
S
G
A
F
V
A
---
R
A
A
--
R
F
M
L
H
A
Q
V
E
A
G
S
--
L
C
P
--
I
T
M
T
F
A
A
T
P
L
L
L
Q
M
LP
A
P
F
Q
D
W
T
T
P
L
L
S
D
R
Y
D
S
H
L
L
P
G
G
QKR
G
L
L
I
G
M
G
M
T
E
K
Q
-
G
-
G
S
D
V
M
S
N
T
T
R
A
E
--
R
--
L
E
D
-
G
S
Y
R
L
V
G
H
K
W
F
F
S
---
V
P
Q
S
--
D
A
H
L
V
L
A
Q
T
A
G
---------------
G
L
S
C
F
F
V
P
R
F
---------
L
P
D
G
Q
--
R
N
A
I
R
L
E
R
-
L
K
D
K
L
---
G
N
RS
N
A
S
C
E
V
E
F
Q
D
A
I
G
---
W
L
L
G
-
L
E
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
L
A
R
A
W
D
R
RAD
A
-----------
K
E
A
----------------
L
W
-
A
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
-
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
V
L
N
K
Q
A
G
V
Y
D
L
L
S
E
A
F
V
E
V
K
G
Q
D
R
Y
F
D
R
A
V
R
R
L
Q
Q
Q
L
R
K
P
A
E
E
L
G
R
E
I
T
H
Q
L
F
L
L
G
C
G
A
Q
M
L
K
Y
A
S
P
P
M
A
Q
A
W
C
Q
V
M
LDTR
G
G
V
R
L
S
E
Q
I
Q
N
D
L
L
L
R
A
T
G
G
V
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------