@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : A8LMB5_DINSH: (2019-01-26 )
MTPGDRMMASALGSWTRLAPFAGLDPAAFEAEELWRREDPGQVRIVLRMRGGAGQDLVFKRVFQPQDRGRWAEALDGQRRAVRALMRDPVHVPPAILAEDAETLSTVQDFVPGRTLQDHMLLRFDKPGARAQVLQRAGRFLAAFHGATAEGDKPFNPATMLDYIRALGRRALSGDLTLADPDLFAVLAEGLEAAAQTAAGQPVRVAAQHGDLHARNLIVSGKRATLIDFAQDRSAPVQYDMARLIVDLGARFSGDAAPEATCGLPAADLAALSDGYGRDLSQDACLAFLCRCRVLQDWAALPAVASQRSAFQQERLLQLQKTATRLAAA
Atome Classification :
(21 SA)
--------------.........10........--20......-..30----....----....-.40-----...-....-.-.50-----------------........60..-...-.---..70-----....-....80..---------....-..90..-...------...100----------.--------.---..----..---...110--------..-..-...---120..-.-------.-...130----.-........140.-..--.------...150-..------.----------.-----.---------.------.160.-......------.170--.-----------.-.-...--..180.-------......190.......200-......-----------.210.......---220-----.-----...-.-.-..230.......240.......250..----------.....260.---..-----------..-..270......----.280.-------------.----------.-....290--....-----...300------...--..-.-----..---.-------310---..-......320.......-----------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------MTP
G
D
R
M
M
A
S
A
LGSWTRLA--PFAGLDP
A
-
A
F
E
-----
A
E
E
L
----WRRE-DP------G
Q
V
-
R
I
V
L
-
R
-MRG-----------------GA
G
Q
D
L
V
F
K
R
VF-QPQ-D---RG
R
W
-----
A
E
A
L-DG
Q
R
R
A
V
R
---------
A
L
M
R-DPVHV
P
-
P
A
I
------
L
AE
D
------------
A
--------
E
---
T
L
----
S
T
---
V
Q
D
FVP--------GR-
T
L
-
Q
D
H
---
M
L
L
R
F-D-------K-P
G
A
R
------
A
-
Q
V
L
Q
R
A
G
R
F
L
A
A
-FH--G------ATAEGD-KP------F----------
N
-----
P
---------
A
------
T
M
-
L
D
-
Y
I
R
A
L
G
------
R
R
A---L-----------S-G-DLT--LA
D
P
D
L
-------
F
A
V
L
A
E
G
L
E
A
A
A
Q
TAAGQ
P
-
V
R
V
A
AQ-----------HGD
L
H
A
R
N
L
I
V---S-G-----K-----
R
A
T
-
L
-
I
-
D
FAQDRSAP
V
Q
Y
D
M
A
R
L
I
V
D
L
GARFSG----------DAAPEATCG---L
P
-----------
A
A
-
D
L
A
A
L
SDGYGR----DL
S
Q
D
-------------
A
----------
C
-
L
A
F
L
C
R
C
--
R
V
L
Q
-----
D
WAA--------
L
P
A
--
V
A
-
S
-----
Q
R
---
S
-------
A
F
----
Q
Q
-
E
R
L
L
Q
L
Q
K
T
A
T
R
LAAA-----------------------------------
22
Fugue
76.66
14%
-1
- C2 -
-
4OCV
2
?
A:
[24-378]
-----------------
T
N
E
A
L
F
D
V
A
S
H
F
A
L
E
G
--
T
V
D
S
I
E
P
Y
G
D
G
H
-----
I
N
T
T
----
Y
L
V
T
-
T
D
------
G
P
R
-
Y
I
L
Q
-
R
-
M
N
T
-----------------
G
I
F
P
D
-------------------
T
-----
V
N
L
M
-
R
N
V
E
L
V
T
S
---------
T
L
K
A
-
Q
G
K
E
T
L
-
D
I
V
------
R
T
T
S
------------
G
--------
D
---
T
W
----
A
E
---
I
D
G
-
G
A
--------
W
R
-
V
Y
-
K
F
I
---
E
H
T
M
S
-
Y
-------
N
-
L
V
P
N
------
P
-
D
V
F
R
E
A
G
R
A
F
G
D
-
F
Q
--
N
------
F
L
S
G
F
D
-
A
N
------
Q
LTETIAHFHD
T
-----
P
---------
H
------
R
F
-
E
D
-
F
K
K
A
L
A
------
A
D
E
---
L
-----------
G
R
A
-
A
G
C
--
G
P
E
I
E
F
-------
Y
L
S
H
A
D
Q
Y
A
V
V
M
D
G
L
R
D
G
S
-
I
P
L
R
V
T
-----------
H
N
D
T
K
L
N
N
I
L
M
DAT
T
-
G
-----
K
-----
A
R
A
-
I
-
I
-
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
S
I
R
F
G
A
S
T
A
L
E
----------
D
E
R
D
L
D
K
V
H
---
F
S
-----------
T
E
-
L
F
R
A
Y
T
E
G
F
V
G
----
E
L
R
D
S
IT
A
R
E
A
E
L
L
P
F
S
G
N
----------
L
-
L
T
M
E
C
G
M
--
R
F
L
A
-----
D
Y
L
E
GDVYFATK
Y
P
E
--
H
N
-
L
-----
V
R
---
S
-------
R
T
----
Q
I
-
K
L
V
R
E
M
E
Q
R
A
D
E
T
R
A
I
V
A
D
V
M
E
T
T---------------------------
47
SP3
74.66
16%
9
- C2 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-----------------
G
M
K
E
L
L
S
T
M
D
L
D
T
D
A
N
--
T
I
P
E
L
K
E
R
-
A
H
M
L
C
A
R
F
L
G
G
A
----
W
K
T
V
-
P
L
------
E
H
L
-
R
I
S
R
-
I
-
K
G
G
MS
N
M
L
F
L
C
R
L
S
EVYPPI
R
N
E
P
N
K
V
L
L
R
V
Y
F
N
P
E
-
T
------------
E
S
H
L
-
V
A
E
S
V
I
F
T
---------
L
L
S
E
-
R
H
--
L
G
-
P
K
L
------
Y
G
I
F
------------
S
--------
G
---
G
R
---------
L
E
E
Y
I
P
--------
S
R
-
P
L
S
C
H
E
---
I
S
-----------------
L
------
A
-
H
M
S
T
K
I
A
K
R
V
A
K
-
V
H
--
Q
------
L
E
V
P
I
W
-
K
------------------
E
-----
P
---------
D
------
Y
L
-
C
E
-
A
L
Q
R
W
L
------
K
Q
L
---
T
G
T
V
--------
D
-
A
-
E
H
R
--
F
D
L
P
E
E
CGVSSVN
C
L
D
L
A
R
E
L
E
F
L
R
A
H
I
S
L
S
K
-
S
P
V
T
F
C
-----------
H
N
D
L
Q
E
G
N
I
L
L
---
P
-
K
-----
R
------
L
V
-
L
-
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
I
D
Y
D
I
----------
D
E
A
P
F
Y
K
I
Q
TEN
F
P
E
N
D
Q
M
------
L
E
-
F
F
L
N
Y
L
R
E
Q
G
N
----
T
R
E
N
E
-------------
L
Y
K
K
S
E
D
L
V
Q
E
T
-
L
P
F
V
P
V
S
--
H
F
F
W
-----
G
V
W
G
--------
L
L
Q
--
V
E
-
L
SPVGF
G
F
---
A
-------
D
Y
----
G
R
-
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A----------------------------------
15
Fugue
67.90
13%
-2
- C2 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
MDLDTD
A
N
T
I
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
GG
A
W
K
T
V
P
L
E
-
H
L
R
-----
I
S
R
I
----
K
G
G
M
-
S
N
------
M
L
F
-
L
C
R
L
-
S
-
E
V
Y
-----------------
P
P
I
R
N
E
P
N
K
V
L
L
-
R
V
Y
-
F
---
N
P
E
T
-----
E
S
H
L
-
V
A
E
S
V
I
F
T
---------
L
L
S
E
-
R
--
H
L
G
-
P
K
L
------
Y
G
I
F
------------
S
--------
G
---------
G
R
---
L
E
E
Y
I
P
--------
S
R
-
P
L
-
S
C
H
---
E
I
S
L
----------------------
A
-
H
M
S
T
K
I
A
K
R
V
A
K
-
V
H
--
Q
------
L
E
V
P
I
W
-
K
E
PD----
Y
----------
L
-----
C
---------
E
------
A
L
-
Q
R
-
W
L
K
Q
L
T
------
G
T
V
---
D
-----------
A
-
E
-
H
R
F
--
D
L
P
E
E
C
GVSSVN-
C
L
D
L
A
R
E
L
E
F
L
R
A
H
I
S
L
S
K
-
S
P
V
T
F
C
-----------
H
N
D
L
Q
E
G
N
I
L
L
---
P
-------
K
-----
R
L
V
-
L
-
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
I
D
Y
D
I
----------
D
E
A
P
F
Y
K
I
Q
---
T
E
NFPE
N
D
Q
M
L
E
F
F
L
-
N
Y
L
R
E
Q
G
N
T
R
E
----
N
E
L
Y
K
-------------
K
----------
S
-
E
D
L
V
Q
E
T
--
L
P
F
V
P
V
S
H
F
F
W
G
V
--------
W
G
L
--
L
Q
-
V
-----
E
L
---
S
PVGFG
F
A
D
Y
----
G
R
-
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A----------------------------------
23
Fugue
67.39
16%
8
- C2 -
-
3CSV
11
?
A:
[4-333]
--------------------
S
R
E
D
E
I
R
D
F
L
A
T
H
--
G
Y
A
D
-----
W
N
R
-----
T
P
R
Y
----
Q
R
L
R
-
S
P
------
T
G
A
-
K
A
V
L
M
D
-
W
S
P
-----------------
E
E
G
G
D
T
-----------------------------
Q
P
F
V
D
L
A
Q
---------
Y
L
R
N
-
L
D
I
S
A
P
-
E
I
Y
------
A
E
E
H
------------
A
--------
R
---
G
L
----
L
L
---
I
E
D
L
--------------
G
-
D
A
L
---
F
T
E
V
I
-
N
-------
N
-
D
P
A
Q
------
E
M
P
L
Y
R
A
A
V
D
L
L
I
H
-
L
H
--
D
------
A
Q
T
P
E
L
-
A
R
------
L
----------
D
-----
P
---------
E
------
T
L
-
S
E
M
T
R
L
A
F
S
------
E
Y
R
---
Y
-----------
A
-
I
-
L
G
D
--
A
-
A
E
D
N
-------
R
K
R
F
E
H
R
F
A
Q
I
L
S
A
Q
L
E
G
D
M
V
F
V
--------------
H
R
D
F
H
A
Q
N
L
L
W
---
L
-
P
EREGL
A
-----
R
V
G
-
V
-
I
-
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
V
S
L
L
Q
D
A
R
R
D
V
P
A
----------
Q
V
E
A
---------
Q
M
----------
I
D
-
H
Y
I
Q
A
T
G
V
D
E
S
----
H
F
R
S
A
-------------
Y
----------
A
-
V
I
A
V
Q
R
N
M
-
R
I
L
G
-----
I
F
A
R
--------
L
S
Q
--
R
F
-
G
-----
K
R
---
H
-------
Y
I
----
E
F
V
P
R
V
W
A
H
F
E
R
G
L
A
H
P
A
L
ASA
A
E
E
I
L
N
A
L
PAPA
P
E
V
L
E
R
L
R
A-----------
16
Fugue
66.83
14%
-18
- C2 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
--------------------
T
L
P
A
V
I
S
R
W
L
S
S
V
--
L
P
G
G
A
A
P
E
-
V
T
V
-----
E
S
G
V
----
D
S
T
G
-
M
S
------
S
E
T
-
I
I
L
T
-
A
-
R
W
Q
-----------------
Q
D
G
R
S
I
Q
Q
K
L
V
A
-
R
V
A
-
P
---
A
A
E
D
VPVFP
T
Y
R
L
-
D
H
Q
F
E
V
I
R
---------
L
V
G
E
L
T
D
V
P
V
P
R
V
R
W
------
I
E
T
T
------------
G
--------
D
---
V
L
----
G
T
P
F
F
L
M
D
Y
V
E
--------
G
V
-
V
P
-
P
D
V
---
M
P
Y
T
F
-
G
DNWFADA
P
-
A
E
R
Q
------
R
-
Q
L
Q
D
A
T
V
A
A
L
A
T
-
L
H
S
I
P
------
N
A
Q
N
T
F
-
S
F
------
L
----------
T
-----
D
---------
T
------
T
L
-
H
R
-
H
F
N
W
V
R
------
S
W
Y
---
D
-----------
F
-
A
-
V
E
G
--
I
G
R
S
P
L
-------
L
E
R
T
F
E
W
L
Q
S
H
W
P
D
D
A
A
A
R
-
E
P
V
L
L
------------
W
G
D
A
R
V
G
N
V
L
Y
---
R
-
D
-----
F
-----
Q
P
V
-
A
-
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
W
M
I
F
A
H
R
V
F
Q
E
L
----------
A
G
L
A
T
L
P
G
L
---
P
E
-----------
V
M
-
R
E
D
D
V
R
A
T
Y
Q
A
----
L
T
G
V
E
-------------
L
----------
G
D
L
H
W
F
Y
V
Y
--
S
G
V
M
-----
W
A
C
V
--------
F
M
R
--
T
G
-
A
-----
R
R
---
V
-------
H
F
GEIE
K
P
-
D
D
V
E
S
L
F
Y
H
A
G
L
M
K
H
L
L
G
EEH------------------------------
11
Fugue
62.74
14%
-31
- C2 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
--------------
T
D
I
T
E
D
E
L
R
N
F
L
T
Q
Y
D
V
---------------------
G
S
L
T
----
S
Y
K
G
-
I
A
------
E
N
S
-
N
F
L
L
-
H
-
T
T
K
-----------------
D
P
----
L
I
L
T
L
Y
-
E
K
K
-
N
---
D
L
P
F
-----
F
L
G
L
M
Q
----------------
H
L
A
A
-
K
G
L
S
C
P
-
L
P
L
------
P
R
K
D
------------
G
--------
E
---
L
L
----
G
E
---
L
S
------------
G
R
-
P
A
-
A
L
I
---
S
F
L
E
G
M
W
-------
L
-
R
K
P
E
------
A
-
K
H
C
R
E
V
G
K
A
L
A
A
M
H
L
--
A
------
S
E
G
F
E
I
-
K
R
------
P
----------
N
-----
A
---------
L
------
S
V
-
D
G
-
W
K
V
L
W
--------
D
K
---
S
-----------
E
-
E
-
R
A
D
--
E
V
E
K
G
L
-------
R
E
E
I
R
P
E
I
D
Y
L
A
A
H
W
P
-
K
D
-
L
P
A
G
V
I
-----------
H
A
D
L
F
Q
D
N
V
F
F
---
L
-
G
D----
E
-----
L
S
G
-
L
-
I
-
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
A
W
C
F
E
K
D
G
----------
A
-----------
Y
N
-----------
V
T
-
K
G
K
A
L
L
E
G
Y
Q
S
V
R
P
L
S
E
A
E
L
-------------
E
----------
A
-
L
P
L
L
S
R
G
--
S
A
L
R
-----
F
F
L
T
--------
R
L
Y
--
D
W
-
L
-----
T
T
---
P
-------
A
G
----
A
L
-
V
V
K
K
D
P
L
E
Y
L
R
K
L
R
F
H
R
T
IANVAEYGLA-----------------------
37
HHSearch
61.90
21%
-22
- C2 -
-
3F7W
7
?
A:
[3-249]
-------------------------
N
S
V
A
A
R
V
T
--
E
L
T
G
R
E
V
A
---
A
-----
V
A
E
R
---------
G
H
------
S
H
R
-
W
H
L
Y
-
R
-
V
E
L
-----------------
A
D
G
T
P
L
F
V
K
-
A
L
-
P
D
D
-
A
PAL
D
G
L
F
-----
R
A
E
A
-
L
G
L
D
W
L
G
R
--------------
S
F
G
S
P
V
-
P
Q
V
------
A
G
W
D
-------------------------
D
R
----
T
L
---
A
M
E
W
V
D
--------
E
R
-
P
P
-
T
-------------------------------
P
-
E
A
A
E
R
F
G
H
Q
L
A
A
-
M
H
--
L
------
A
G
A
E
S
F
-
G
A
------
T
----------
W
-----
D
G
Y
IGP
L
P
M
D
N
------
T
P
-
R
S
-
T
W
P
E
F
Y
A
E
QRI
L
P
Y
L
---
R
-----------
R
-
A
-
A
D
R
--
G
A
L
T
P
G
-------
D
V
R
L
V
E
K
V
L
D
A
L
D
H
L
A
G
D
P
-
E
P
P
A
R
I
-----------
H
G
D
L
W
N
G
N
V
L
W
---
Q
-
D
-----
D
-----
G
A
V
-
V
-
I
-
D
P
A
-
A
H
G
G
H
R
E
A
D
L
A
M
L
A
L
F
G
L
-----------------------------------------
P
-
Y
L
D
R
V
R
D
A
Y
N
E
----
V
A
P
L
A
-------------
E
---------------------------------------------------------------------------------------------------------------------------------
19
Fugue
61.89
11%
-21
- C2 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
--------------
K
T
P
L
Y
E
T
L
-----
N
E
S
S
A
V
--
A
L
A
V
K
L
G
L
-
T
L
T
-----
C
Q
E
I
----
G
D
G
N
-
L
N
------
Y
V
F
-
H
I
Y
--------------------------
D
R
A
L
I
I
K
Q
A
---
V
P
-
Y
---
W
P
L
T
-----
I
D
R
A
-
R
I
E
S
S
A
L
I
---------
R
Q
G
E
-
H
V
P
H
L
V
-
P
R
V
------
F
Y
S
D
------------
T
--------
E
---
M
A
----
V
T
---
V
M
E
D
L
S
--------
H
L
-
K
I
-
A
R
K
---
G
L
I
E
G
-
E
-------
N
Y
P
H
L
S
------
Q
-
H
I
G
E
F
L
G
K
T
L
F
Y
-
S
S
--
D
YALE
P
K
V
K
K
Q
L
V
-
K
Q
------
F
----------
T
-----
N
---------
P
------
E
L
-
C
D
-
I
T
E
R
L
V
------
F
T
D
---
P
FFDHDT
N
D
F
E
E
E
-
L
-
R
P
F
--
V
E
K
L
W
N
-------
N
D
S
V
K
I
E
A
A
K
L
K
K
S
F
L
T
S
A
-
E
T
L
I
-------------
H
G
D
L
H
T
G
S
I
F
A
---
S
-
E
-----
H
-----
E
T
K
-
V
-
I
-
D
P
E
F
A
F
Y
G
P
I
G
F
D
V
G
Q
F
I
A
N
L
F
L
N
A
L
S
R
DGADR
E
P
L
Y
E
H
V
N
Q
V
W
E
T
---
F
E
-----------
E
T
-
F
S
E
A
W
Q
K
D
S
L
D
----
V
Y
A
N
I
-------------
D
----------
G
-
Y
L
T
D
T
L
S
--
H
I
F
E
-----
E
A
I
G
--------
F
A
G
--
C
E
-
L
-----
I
R
---
R
-------
T
I
----
G
L
-
A
H
V
A
D
L
D
T
I
V
P
F
D
K
R
I
G
R
K
R
L
A
L
E
T
G
T
A
F
I
E
KRSEFKT
I
T
D
V
I
E
L
F
K
L
L
V
K
10
Fugue
61.00
14%
-4
- C2 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
-------------S
A
F
T
F
Q
T
L
H
P
D
T
I
M
D
A
L
F
E
H
--
G
I
R
--------
V
-----
D
S
G
L
----
T
P
L
N
-
S
Y
------
E
N
R
-
V
Y
Q
F
-
Q
-
D
E
D
-----------------
R
R
R
F
V
V
K
F
Y
R
-----------
P
E
R
W
T----
A
D
Q
I
-
L
E
E
H
Q
F
A
L
---------
Q
L
V
N
-
D
E
V
P
V
A
-
A
P
V
A
F
NGQT
L
L
N
H
------------
Q
--------
G
---
F
Y
----
F
A
---
V
F
P
S
V
G
--------
G
R
-
Q
F
-
E
A
D
----------------------
N
------
I
-
D
Q
M
E
A
V
G
R
Y
L
G
R
-
M
H
--
Q
------
T
G
R
K
Q
L
F
I
H
------
R
----------
P
-----
T
---------
I
------
G
L
-
N
E
-
Y
L
I
E
P
R
------
K
L
F
---
E
D
----------
A
-
T
-
L
I
P
--
S
G
L
K
A
A
-------
F
L
K
A
T
D
E
L
I
A
A
V
T
A
H
W
R
E
D
-
F
T
V
L
R
L
-----------
H
G
D
C
H
A
G
N
I
L
W
---
R
-
D
-----
G
------
P
M
-
F
-
V
-
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
L
L
N
G
D
K
A
E
Q
R
M
----------
Q
L
E
T
I
I
E
A
Y
---
E
E
-----------
F
S
-
E
F
D
T
A
E
I
G
L
I
E
----
P
L
R
A
M
-------------
R
----------
L
-
V
Y
Y
L
A
W
L
--
M
R
R
W
-----
A
D
P
A
--------
F
P
K
N
F
P
W
-
L
-----
T
G
---
E
-------
D
Y
----
W
L
-
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
E
P
PLQLTPMY---------------------------
12
Fugue
60.08
12%
-39
- C2 -
-
3I1A
2
?
A:
[3-330]
-------------------
K
Q
P
I
Q
A
Q
Q
L
I
E
L
L
K
--
V
H
Y
G
I
D
I
H
-
T
A
Q
-----
F
I
Q
G
----
G
A
D
T
-
N
A
------
F
A
Y
-
Q
A
D
-------------------------
S
E
S
K
S
Y
F
I
K
L
K
-
Y
G
Y
-------
H
D
-----
E
I
N
L
-
S
I
I
R
L
L
H
D
---------
S
G
I
K
-
E
I
I
F
P
I
-
H
T
L
------
E
A
K
L
------------
F
--------
Q
---
Q
L
----
K
H
---
F
K
I
I
A
Y
--------
P
F
-
I
H
-
A
P
-------
N
G
-
F
-------
T
-
Q
N
L
T
------
G
-
K
Q
W
K
Q
L
G
K
V
L
R
Q
-
I
H
--
E
------
T
S
V
P
I
S
-
I
Q
------
Q
----------
Q
-----
L
---------
R
KEIYSP
K
W
-
R
E
-
I
V
R
S
F
Y
------
N
Q
I
---
E
-----------
F
-
D
-
N
S
D
--
D
K
L
T
A
A
-------
F
K
S
F
F
N
Q
N
S
A
A
I
H
R
L
V
D
T
S
-
E
K
L
S
K
K
IQPDLDKYVLC
H
S
D
I
H
A
G
N
V
L
V
---
G
N
E
-----
E
-----
S
I
Y
-
I
-
I
-
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
I
G
G
G
V
G
N
V
W
N
------------------------
K
-----------
P
H
-
E
I
Q
Y
F
Y
E
G
Y
G
E
----
I
N
V
D
K
-------------
T
----------
I
-
L
S
Y
Y
R
H
E
--
R
I
V
E
-----
D
I
A
V
--------
Y
G
Q
--
D
L
-
L
-----
S
R
NQN
N
-------
Q
S
----
R
L
-
E
S
F
K
Y
F
K
E
M
F
D
P
N
N
V
V
E
I
A
F
A
T
E----------------------------
50
SP3
59.42
14%
1
- C2 -
-
1B6C
-
TGFR1_HUMAN
B:
[14-339]
--------------
T
T
L
K
D
L
I
Y
D
M
-------
T
T
--
S
G
S
G
S
G
L
P
-
L
L
V
-----
Q
R
T
I
----
A
R
T
I
-
V
L
Q
E
SIGK
G
R
F
-
G
E
V
W
-
R
-
G
K
------------------
W
R
G
E
E
V
A
V
K
I
F
S
-
S
R
E
-
E
---
R
S
W
F
-----
R
E
A
E
-
I
Y
Q
T
V
M
L
R
HENILGFI
A
A
D
N
K
-
D
N
G
T
W
T
-
Q
L
W
------
L
---------------------------------------
V
S
D
Y
H
E
--------
H
G
-
S
L
-
F
D
Y
---
L
N
R
Y
T
-
V
-------
T
-
V
E
G
M
------
I
-
K
L
A
L
S
T
A
S
G
L
A
H
-
L
H
M
-
E
------
I
V
G
T
Q
G
-
K
P
A
IAHRD
L
----------
K
-----
S
---------
K
------
N
I
-
L
--------------------
V
-----------
K
-
K
-
N
G
T
C
C
I
A
D
----------
L
G
-
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
-
N
H
R
V
G
T
-----------
K
R
-
Y
M
A
P
E
V
L
-------------------
D
D
-
S
-
I
-
N
M
-
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
CSIGG
I
H
E
--
D
Y
Q
L
P
Y
Y
D
L
---
V
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
----
Q
K
L
R
P
-------------
N
----------
I
-
P
N
R
W
Q
S
C
--
E
A
L
R
-----
V
M
A
K
--------
I
M
R
--
E
C
-
W
-----
Y
A
---
N
-------
G
A
----
A
R
-
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G---------------------------------
33
HHSearch
56.90
17%
-20
- C2 -
-
5UXD
2
?
A:
[5-253]
-----------------------
E
D
L
D
A
L
L
D
L
A
--
A
R
H
G
L
D
L
D
-
G
G
T
-----
L
R
T
E
---------
E
I
------
G
L
D
-
F
R
V
A
-
F
-
A
R
A
-----------------
H
D
G
G
D
W
V
L
R
-
L
P
-
R
R
P
D
V
---
L
E
R
A
-----
A
V
E
G
-
R
L
L
A
M
L
A
P
--------------
H
L
D
V
A
V
-
P
D
W
------
R
I
S
T
-------------------------
S
E
----
L
I
---
A
Y
P
L
L
P
--------
G
S
-
P
G
-
L
T
V
---
A
A
D
G
E
-
V
S
W
H----
V
-
D
M
A
S
------
T
-
V
Y
A
R
S
L
G
S
V
V
A
Q
-
L
H
--
A
------
V
D
A
E
A
A
-
A
A
------
T
G
I
E
V
R
-----
S
-----
P
---------
A
------
Q
V
-
R
G
-
A
W
R
Q
D
L
------
A
R
V
---
G
-----------
A
-
E
---------
F
E
I
-------
A
P
A
L
R
E
R
W
E
A
W
L
A
D
D
G
C
W
P
-
G
H
S
V
L
T
-----------
H
G
E
L
Y
P
A
H
T
L
V
---
E
-
D
-----
E
R----
I
T
A
-
V
-
L
-
D
W
T
T
A
A
V
G
D
P
A
K
D
L
M
F
H
Q
V
S
A
P
----------------------------------------
S
A
-
I
F
E
V
A
L
Q
A
Y
A
E
----
G
G
G
-------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
56.50
15%
11
- C2 -
-
4R78
2
?
A:
[18-304]
-----------------
G
S
H
M
E
K
I
I
K
E
K
I
S
S
L
L
--
S
Q
E
E
-
E
-
V
--
L
S
-----
V
E
Q
----------
L
G
------
G
M
T
-
N
Q
N
Y
-
L
-
A
K
T
-----------------
T
N
-
K
Q
Y
I
V
K
-
F
F
-
G
K
G
-
T
EK-
L
I
N
R
-----
Q
D
E
K
-
Y
N
L
E
L
L
K
---------------
D
L
G
L
D
V
-
K
N
Y
------
L
F
D
I
---------------------
E
---
A
G
----
I
K
---
V
N
E
Y
I
E
--------
S
A
I
T
L
-
D
S
T
---
S
------------------
I
------
K
-
T
K
F
D
K
I
A
P
I
L
Q
T
-
I
H
--
T
------
S
A
K
E
L
R
-
G
E
------
F
----------
A
-----
P
---------
F
------
E
E
-
I
K
-
K
Y
E
S
L
I
------
E
E
Q
---
I
-----------------
P
--
Y
A
N
Y
E
S
-------
V
R
N
A
V
F
S
L
E
K
---
R
L
A
D
L
G
-
V
D
R
K
S
C
-----------
H
I
D
L
V
P
E
N
F
I
E
---
S
-
P
Q----
G
-----
R
L
Y
-
L
-
I
-
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
E
S
E
F
T
--------------------------------------
S
Q
-
E
E
E
T
F
L
S
H
Y
E
S
----
D
Q
T
P
V
-------------
S
H
E
--------
K
-
I
A
I
Y
K
I
L
Q
D
T
I
W
S
-----
L
W
T
V
--------
Y
K
E
--
E
Q
G
E
-----
D
F
---
G
-------
D
Y
----
G
V
-
N
R
Y
Q
R
A
V
K
G
L
A
S
Y
G
-------------------------------------
28
HHSearch
56.41
15%
9
- C2 -
-
4R7B
-
?
A:
[18-304]
-----------------
G
S
H
M
E
K
I
I
K
E
K
I
S
S
L
L
--
S
Q
E
E
-
E
-
V
--
L
S
-----
V
E
Q
----------
L
G
------
G
M
T
-
N
Q
N
Y
-
L
-
A
K
T
-----------------
T
N
-
K
Q
Y
I
V
K
-
F
F
-
G
K
G
-
T
EK-
L
I
N
R
-----
Q
D
E
K
-
Y
N
L
E
L
L
K
---------------
D
L
G
L
D
V
-
K
N
Y
------
L
F
D
I
---------------------
E
---
A
G
----
I
K
---
V
N
E
Y
I
E
--------
S
A
I
T
L
-
D
S
T
---
S
------------------
I
------
K
-
T
K
F
D
K
I
A
P
I
L
Q
T
-
I
H
--
T
------
S
A
K
E
L
R
-
G
E
------
F
----------
A
-----
P
---------
F
------
E
E
-
I
K
-
K
Y
E
S
L
I
------
E
E
Q
---
I
-----------------
P
--
Y
A
N
Y
E
S
-------
V
R
N
A
V
F
S
L
E
K
---
R
L
A
D
L
G
-
V
D
R
K
S
C
-----------
H
I
D
L
V
P
E
N
F
I
E
---
S
-
P
Q----
G
-----
R
L
Y
-
L
-
I
-
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
E
S
E
F
T
--------------------------------------
S
Q
-
E
E
E
T
F
L
S
H
Y
E
S
----
D
Q
T
P
V
-------------
S
H
E
--------
K
-
I
A
I
Y
K
I
L
Q
D
T
I
W
S
-----
L
W
T
V
--------
Y
K
E
--
E
Q
G
E
-----
D
F
---
G
-------
D
Y
----
G
V
-
N
R
Y
Q
R
A
V
K
G
L
A
S
Y
G
-------------------------------------
48
SP3
54.67
14%
7
- C2 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
--------------------------------------
G
S
-
P
A
-
A
W
------
V
E
R
L
FG
Y
D
W
A
Q
Q
-
T
I
------
G
C
S
D
A
A
V
F
-
R
-
L
S
A
-----------------
Q
G
R
P
V
L
F
V
K
T
-----
D
-
L
---
S
G
-
A
-----
L
N
E
L
-
Q
D
E
A
A
R
L
S
---------
W
L
A
T
-
T
G
V
P
C
A
-
A
V
L
D
-----
V
V
T
E
------------
A
--------
G
---
R
D
----
W
L
---
L
L
G
E
V
P
--------
G
Q
-
D
L
-----------
L
-
S
-------
S
-
H
L
A
P
------
A
-
E
K
V
S
I
M
A
D
A
M
R
R
-
L
H
--
T
------
L
D
P
A
-
T
-
C
P
------
F
----------
D
HQ---
A
---------
K
------
H
R
-
I
E
-
R
A
R
T
R
M
------
E
A
G
---
L
-----------
V
---
D
Q
D
--
D
L
D
E
E
H
-------
Q
G
L
A
P
A
E
L
F
A
R
L
K
A
R
M
P
D
G
-
E
D
L
V
V
T
-----------
H
G
D
A
C
L
P
N
I
M
V
---
E
-
N
-----
G
-----
R
F
S
-
G
F
I
-
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
T
R
D
I
A
E
E
L
G
------------------------------------
G
E
-
W
A
D
R
F
L
V
L
Y
G
I
----
A
---
A
-------------
P
----------
D
-
S
Q
R
I
A
F
Y
--
R
L
L
D
-----
E
F
F
------------------------------------------------------------------------------------------------
31
HHSearch
54.57
14%
-39
- C2 -
-
2PPQ
-
KHSE_AGRFC
A:
[6-259]
----------------------
D
I
T
E
D
E
L
R
N
F
L
--
T
Q
Y
D
V
G
-
S
-
L
T
S
-----
Y
K
G
I
---------
A
E
----------
N
S
N
F
-
L
-
L
H
T
-----------------
T
K
-
D
P
L
I
L
T
-
L
Y
-
E
K
------
K
N
D
L
-----
P
F
F
L
-
G
L
M
Q
H
L
A
---------------
A
K
G
L
S
C
-
P
L
P
------
L
P
R
K
------------
D
GEL
L
G
E
L
S
G
---
R
P
----
A
A
---
L
I
S
F
L
E
--------
G
M
-
W
L
-
R
K
P
----------------------
E
------
A
-
K
H
C
R
E
V
G
K
A
L
A
A
-
M
H
--
L
------
A
S
E
G
F
E
-
I
K
------
R
----------
P
-----
N
---------
A
------
L
S
-
V
D
-
G
W
K
V
L
W
------
D
K
S
---
E
-----------
E
-
R
-
A
D
E
--
V
--
E
K
G
-------
L
R
E
E
I
R
P
E
I
D
Y
L
A
A
H
W
P
K
D
-
L
P
A
G
V
I
-----------
H
A
D
L
F
Q
D
N
V
F
F
---
L
-
G
D----
E
-----
L
S
G
-
L
-
I
-
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
A
W
C
F
E
K
D
G
----------
A
-----------
Y
N
-----------
V
T
-
K
G
K
A
L
L
E
G
Y
Q
S
----
V
R
P
L
S
-------------
E
---------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
54.08
26%
-27
- C2 -
-
1ZYL
-
SRKA_ECOLI
A:
[39-234]
----------------------------------------------------------------------------------------------------------------
N
R
V
Y
-
Q
F
Q
-
D
---
E
D
R
--------------
R
R
F
V
V
---------
K
F
Y
R
-
P
E
R
W
T
A
-
D
Q
I
------
L
E
E
H
------------
Q
--------
F
---
A
L
----
Q
L
---
V
N
D
E
V
P
VA
A
P
V
A
F
N
G
Q
-
T
L
-
L
N
H
QG
F
Y
F
A
V
F
-
P
-------
S
-
V
G
G
R
QFEADN
I
-
D
Q
M
E
A
V
G
R
Y
L
G
R
-
M
H
--
Q
------
T
G
R
K
Q
L
-
F
I
------
H
----------
R
-----
P
---------
T
------
I
G
-
L
N
E
Y
L
--
I
E
------
P
R
K
---
L
-----------
F
-
E
-
D
A
T
--
L
I
P
S
G
L
K
A
A
----
F
L
K
A
T
D
E
L
I
A
A
V
T
A
H
W
R
E
D
-
F
T
V
L
R
L
-----------
H
G
D
C
H
A
G
N
-
I
L
---
W
-
R
-----
D
-----
G
P
M
-
F
-
V
-
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
53.64
18%
24
- C2 -
-
3CSV
8
?
A:
[4-254]
-----------------------
S
R
E
D
E
I
R
D
F
L
--
A
T
H
G
Y
A
-
D
--
W
N
-----
R
T
P
------------------------
R
Y
-
Q
R
L
R
S
-----------------
P
T
G
A
K
A
V
L
M
-
D
W
-
S
P
E
-
E
---
G
G
D
T
-----
Q
P
F
V
-
D
L
A
Q
Y
L
R
---------------
N
L
D
I
S
A
-
P
E
I
------
Y
A
E
E
------------
H
--------
A
---
R
G
----
L
L
---
L
I
E
D
L
G
--------
D
A
-
L
F
-
T
E
V
---
I
N
N
D
------------
P
A
Q
E
------
M
-
P
L
Y
R
A
A
V
D
L
L
I
H
-
L
H
--
D
------
A
Q
T
P
E
L
-
A
R
------
L
----------
D
-----
P
---------
E
------
T
L
-
S
E
-
M
T
R
L
A
F
------
S
E
Y
---
R
-----------
Y
-
A
-
I
L
G
--
D
A
A
E
D
N
-------
R
K
R
F
E
H
R
F
A
Q
I
L
S
A
--
Q
L
E
-
G
D
M
V
F
V
-----------
H
R
D
F
H
A
Q
N
L
L
W
---
L
-
P
-----
E
REGLA
R
V
G
-
V
-
I
-
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
V
S
L
L
Q
D
A
R
R
D
V
-------------------------
P
-----------
A
Q
-
V
E
A
Q
M
I
D
H
Y
I
Q
----
A
T
G
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
51.92
14%
-7
- C2 -
-
6EF6
2
?
A:
[27-297]
------------------------
D
V
T
I
A
Q
Q
A
L
--
T
H
Y
D
V
S
-
D
-
N
A
S
-----
L
R
L
L
----------
N
------
L
S
E
-
N
A
T
Y
-
L
-
V
E
D
-----------------
G
-
E
H
Q
S
I
L
R
-
V
H
-
R
Q
D
-
Y
HQ-
P
H
E
I
-----
E
S
E
L
-
D
W
L
A
A
L
R
T
--------------
D
S
D
V
T
V
-
P
T
V
------
V
P
A
R
DGRR
V
V
T
V
D
P
A
D
V
--------
P
---
R
H
----
V
V
---
H
F
E
M
V
G
--------
G
A
-
E
P
-
D
E
E
---
S
-----------------
L
T
------
L
-
D
D
F
Q
T
L
G
R
I
T
A
S
-
L
H
--
E
------
H
S
Q
R
W
T
-
R
P
------
A
G
F
--------
G
-----
R
---------
F
------
S
W
D
W
E
-
H
C
L
G
D
T
------
P
R
W
GRW
Q
-----------
D
-
A
E
G
V
G
--
A
S
E
T
A
L
-------
L
T
R
A
Q
D
L
L
H
R
K
L
E
E
Y
G
S
G
P
-
D
R
Y
G
L
I
-----------
H
A
D
L
R
L
A
N
L
L
V
---
D
-
S
STPQ-
R
-----
T
I
T
-
V
-
I
-
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
G
T
A
V
S
F
I
E
H
D
P
R
------------------------
L
-----------
G
E
-
W
Q
E
S
W
V
A
G
Y
R
S
----
R
R
E
L
P
-------------
A
---------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
51.83
16%
-37
- C2 -
-
5IGI
3
?
A:
[8-256]
------------------------
D
T
S
Q
L
Y
A
L
A
--
A
R
H
G
L
K
-
L
-
H
G
P
-----
L
T
V
N
---------
E
L
------
G
L
D
-
Y
R
I
V
-
I
-
A
T
V
-----------------
D
D
G
R
R
W
V
L
R
-
I
P
-
R
R
A
-
E
V
--
S
A
K
V
-----
E
P
E
A
-
R
V
L
A
M
L
K
N
--------------
R
L
P
F
A
V
-
P
D
W
------
R
V
A
N
------------
A
--------
E
L
V
A
Y
P
MLED
S
T
---
A
-
V
I
Q
P
--------
G
S
-
S
T
-
P
D
W
---
V
-------------
V
-
P
Q
D
S
------
E
-
V
F
A
E
S
F
A
T
A
L
A
A
-
L
H
--
A
------
V
P
I
S
A
A
-
V
D
------
A
----------
G
MLIRT
P
---------
T
------
Q
A
-
R
Q
-
K
V
A
D
D
V
------
D
R
V
---
R
-----------
R
-
E
------
F
V
---
V
-------
N
D
K
R
L
H
R
W
Q
R
W
L
D
D
D
S
S
W
P
-
D
F
S
V
V
V
-----------
H
G
D
L
Y
V
G
H
V
L
I
---
D
-
N
T----
E
R----
V
S
G
-
M
-
I
-
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
L
M
V
F
G
----------------------------------------
E
E
-
G
L
A
K
L
L
L
T
Y
E
A
----
A
G
G
-------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
49.47
15%
-10
- C2 -
-
3TDW
1
?
A:
[4-238]
-----------------------
N
K
L
H
Y
T
T
M
I
M
--
T
Q
F
P
D
I
-
S
---------
I
--
Q
----
S
V
E
S
L
G
E
------
G
F
R
-
N
Y
A
I
-
L
-
V
N
--------------------
G
-
D
W
V
F
R
-
F
P
-
K
S
Q
-
Q
G
--
A
D
E
L
-----
N
K
E
I
-
Q
L
L
P
L
L
V
G
--------------
C
V
K
V
N
I
-
P
Q
Y
------
V
Y
I
G
------------
K
R
SD-----
G
---
N
P
----
F
V
---
G
Y
R
K
V
Q
--------
G
Q
-
I
L
-
G
E
D
---
G
M
A
-
V
-
L
-------
P
-
D
D
A
K
------
D
-
R
L
A
L
Q
L
A
E
F
M
N
E
-
L
S
--
A
------
F
P
V
E
T
A
-
I
S
------
A
----------
G
-----
V
P
V
-------
T
------
N
L
-
K
N
-
K
I
L
L
L
S
------
E
A
V
---
E
-----------
D
-
Q
-
V
F
P
--
L
L
D
E
S
L
-------
R
D
Y
L
T
L
R
F
Q
S
Y
M
T
H
P
V
Y
T
R
-
Y
T
P
R
L
I
-----------
H
G
D
L
S
P
D
H
F
L
T
---
N
-
L
NSRQ-
T
-----
P
L
T
G
I
-
I
-
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
V
Y
L
L
E
D
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------