@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : A9AZC6_HERA2: (2019-01-26 )
MQINPALAQAIEADSGFELTQVEFIGAGWFAQAYRFCSQAKHYVVRISKHYHDFLKDVYAYQHWGQQLPIPAILAHGQFADGWAYAISPHIAGQTIVSLEAAELRQIQPALFKSLQQLHQLKLGPVTGWGSVNSQGHGRYQSWAEEVLDIGNYKFDFDWHDWIKRDDQTGTLLRQGYRLMEQLLSTISTERSLIHRDFGFDNVLCQPPTIVAVLDWADFGYGDWVYDIAQQSCYGQAEIYLQPWLKFAQQHDLIPDNFEKRLHCYWLRMNLTDLIVSQLRNDWHWQRKIVAELSWLIENPVVVRLNQ
Atome Classification :
(20 SA)
--.........10.....--.--..20........30........40......--.-.50-----.......-.60..---...----.---..70......---.-.---80........90..-.....--.-----100---.........110.----......120........130...--.-----...140.......-150.......160.......170.......180.....-..190....--.....200.....----..210.......220.......230..-----------...---..240...--.--------..-.250..--.---....260-------.........270.......280-......-----...290.......300.....-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--MQI
N
P
A
L
A
Q
A
IEADSG--F--
E
L
T
Q
V
E
F
IG
A
G
W
F
A
Q
A
Y
R
F
C
S
QA
K
H
Y
V
V
R
I
--
S
-
K
H
Y
-----
H
D
F
L
K
D
V
-
Y
A
Y
Q
H
---WGQ----Q---LP
I
P
A
I
LAHG---Q-F---ADG
W
A
Y
A
ISPHIAG-
Q
T
I
V
S
--
L
-----
E
-----
A
A
E
L
R
Q
I
Q
P
A
L
F
K
----
S
L
Q
Q
L
H
Q-LKLGPVTGWGSVNSQ--G-----H
G
R
Y
Q
S
W
A
E
E
V
L
D
-IG
N
Y
K
F
DF
D
W
H
D
W
IKRDDQ
T
G
T
L
L
R
Q
G
Y
R
L
M
E
Q
L
L
S
T
I
-
S
T
E
--
R
S
L
I
--
H
RDFGFDNVLCQP----P
T
I
V
A
V
L
DWADFGY
G
D
W
V
Y
D
I
A
Q
Q
SCY-----------GQ
A
---
E
I
Y
L
Q
P
W
L
--
K
--------
F
A
-
Q
QHDLI--
P
---
D
N
F
E
K---------
R
L
H
C
Y
W
L
RM
N
L
T
D
L
I
V
S
Q
L
R
---N
D
W
H
W
Q
-----
R
K
I
V
A
E
L
S
W
L
IEN
P
V
V
V
R
LNQ-
7
PsiBlast_PDB
82.90
27%
-34
- C4 -
-
3W0S
2
KHYB_ECOLX
A:
[20-274]
---------------
D
S
V
--
S
--
D
L
M
Q
---
L
S
E
G
E
E
S
R
A
F
S
F
D
V
G
G
R
G
Y
V
L
R
V
--
N
-
S
C
A
-----
D
G
F
Y
K
D
R
-
Y
V
Y
R
H
---
F
A
S
----
A
A--
L
P
I
P
E
V
L
D
I
G
---
E
-
F
---
S
E
S
L
T
Y
C
I
S
R
R
A
Q
G
-
V
T
L
Q
D
--
L
-----
P
-----
E
T
E
L
P
A
V
L
Q
P
V
A
E
----
A
M
D
A
I
A
A
-
A
D
L
S
Q
T
S
G
F
G
P
F
G
P
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
C
A
-
I
A
D
P
H
V
-
Y
H
W
Q
T
V
M
--
D
D
T
V
S
A
S
V
A
Q
A
L
D
E
L
M
L
W
A
E
D
C
-
P
E
V
--
R
H
L
V
--
H
A
D
F
G
S
N
N
V
L
T
D
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
S
Q
Y
E
V
A
N
I
---------------------
F
F
W
R
P
W
L
--
A
--------
C
M
-
E
Q
Q
T
R
Y
--------
F
E
R
R
H
PELAGS
P
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
------------------------------------------
33
HHSearch
80.96
24%
-23
- C4 -
-
3W0S
2
KHYB_ECOLX
A:
[6-278]
----
L
T
A
T
S
V
E
K
F
L
I
E
K
F
--
D
--
S
V
S
D
L
M
Q
L
S
E
G
E
E
S
R
A
F
S
F
D
V
G
G
R
G
Y
V
L
R
V
--
N
-
S
C
A
-----
D
G
F
Y
K
D
R
-
Y
V
Y
R
H
---
F
A
S
A---
A
---
L
P
I
P
E
V
L
D
I
G
---
E
-
F
S--
E
S
-
L
T
Y
C
I
S
R
R
A
Q
G
-
V
T
L
Q
D
--
L
-----
P
-----
E
T
E
L
P
A
V
L
Q
P
V
A
E
----
A
M
D
A
I
A
A
-
A
D
L
S
Q
T
S
G
F
G
P
F
G
P
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
C
A
-
I
A
D
P
H
V
Y
H
-
W
Q
T
V
M
D
D
--
T
V
S
A
S
V
A
Q
A
L
D
E
L
M
L
W
A
E
D
C
-
P
E
V
--
R
H
L
V
--
H
A
D
F
G
S
N
N
V
L
T
D
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
S
Q
Y
E
V
A
N
I
F
F
W
-----------
R
-------
P
W
L
A
C
M
--
E
Q
Q
T
R
----
Y
F
E
R
R
H
P
E
L
-------
A
G
S
P
---------
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
Y
Q
S
L
--------------------------------------
2
PsiBlast_PDB
80.40
27%
-33
- C4 -
-
3W0N
2
KHYB_ECOLX
A:
[28-274]
------------------------------
L
S
E
G
E
E
S
R
A
F
S
F
D
V
G
G
R
G
Y
V
L
R
V
--
N
-
S
C
A
-----
D
G
F
Y
K
D
R
-
Y
V
Y
R
H
---
F
A
S
----
A
A--
L
P
I
P
E
V
L
D
I
G
---
E
-
F
---
S
E
S
L
T
Y
C
I
S
R
R
A
Q
G
-
V
T
L
Q
D
--
L
-----
P
-----
E
T
E
L
P
A
V
L
Q
P
V
A
E
----
V
M
D
A
I
A
A
-
A
D
L
S
Q
T
S
G
F
G
P
F
G
P
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
C
A
-
I
A
D
P
H
V
-
Y
H
W
Q
T
V
M
--
D
D
T
V
S
A
S
V
A
Q
A
L
D
E
L
M
L
W
A
E
D
C
-
P
E
V
--
R
H
L
V
--
H
A
D
F
G
S
N
N
V
L
T
D
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
---------------------
F
F
W
R
P
W
L
--
A
C
M
E
Q
Q
A
R
Y
F
E
-
R
R
H
P
E
L
--
A
---
G
S
--
P
---------
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
------------------------------------------
1
PsiBlast_PDB
80.20
27%
-27
- C4 -
-
3W0M
1
KHYB_ECOLX
A:
[28-274]
------------------------------
L
S
E
G
E
E
S
R
A
F
S
F
D
V
G
G
R
G
Y
V
L
R
V
--
N
-
S
C
A
-----
D
G
F
Y
K
D
R
-
Y
V
Y
R
H
---
F
A
S
----
A
A--
L
P
I
P
E
V
L
D
I
G
---
E
-
F
---
S
E
S
L
T
Y
C
I
S
R
R
A
Q
G
-
V
T
L
Q
D
--
L
-----
P
-----
E
T
E
L
P
A
V
L
Q
P
V
A
E
----
V
M
D
A
I
A
A
-
A
D
L
S
Q
T
S
G
F
G
P
F
G
P
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
C
A
-
I
A
D
P
H
V
-
Y
H
W
Q
T
V
M
--
D
D
T
V
S
A
S
V
A
Q
A
L
D
E
L
M
L
W
A
E
D
C
-
P
E
V
--
R
H
L
V
--
H
A
D
F
G
S
N
N
V
L
T
D
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
---------------------
F
F
W
R
P
W
L
--
A
C
M
E
Q
Q
A
R
Y
F
E
-
R
R
H
P
E
L
--
A
---
G
S
--
P
---------
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
------------------------------------------
5
PsiBlast_PDB
79.86
26%
-34
- C4 -
-
3W0P
2
KHYB_ECOLX
A:
[28-274]
------------------------------
L
S
E
G
E
E
S
R
A
F
S
F
D
V
G
G
R
G
Y
V
L
R
V
--
N
-
S
C
A
-----
D
G
F
Y
K
D
R
-
Y
V
Y
R
H
---
F
A
S
----
A
A--
L
P
I
P
E
V
L
D
I
G
---
E
-
F
---
S
E
S
L
T
Y
C
I
S
R
R
A
Q
G
-
V
T
L
Q
D
--
L
-----
P
-----
E
T
E
L
P
A
V
L
Q
P
V
A
E
----
V
M
D
A
I
A
A
-
A
D
L
S
Q
T
S
G
F
G
P
F
G
P
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
C
A
-
I
A
D
P
H
V
-
Y
H
W
Q
T
V
M
--
D
D
T
V
S
A
S
V
A
Q
A
L
D
E
L
M
L
W
A
E
D
C
-
P
E
V
--
R
H
L
V
--
H
A
A
F
G
S
N
N
V
L
T
D
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
---------------------
F
F
W
R
P
W
L
--
A
C
M
E
Q
Q
A
R
Y
F
E
-
R
R
H
P
E
L
--
A
---
G
S
--
P
---------
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
------------------------------------------
35
HHSearch
79.70
24%
-25
- C4 -
-
3W0O
2
KHYB_ECOLX
A:
[9-278]
-------
T
S
V
E
K
F
L
I
E
K
F
--
G
--
S
V
S
D
L
M
Q
L
S
E
G
E
E
S
R
A
F
S
F
D
V
G
G
R
G
Y
V
L
R
V
--
N
-
S
C
A
-----
D
G
F
Y
K
D
R
-
Y
V
Y
R
H
---
F
A
S
A---
A
---
L
P
I
P
E
V
L
D
I
G
---
E
-
F
S--
E
S
-
L
T
Y
C
I
S
R
R
A
Q
G
-
V
T
L
Q
D
--
L
-----
P
-----
E
T
E
L
P
A
V
L
Q
P
V
A
E
----
V
M
D
A
I
A
A
-
A
D
L
S
Q
T
S
G
F
G
P
F
G
P
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
C
A
-
I
A
D
P
H
V
Y
H
-
W
Q
T
V
M
D
D
--
T
V
S
A
S
V
A
Q
A
L
D
E
L
M
L
W
A
E
D
C
-
P
E
V
--
R
H
L
V
--
H
A
D
F
G
S
N
N
V
L
T
D
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
F
F
W
-----------
R
-------
P
W
L
A
C
M
--
E
--------
Q
Q
A
R
Y
F
E
R
R
--
H
PE-
L
A
G
S
P
---------
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
Y
Q
S
L
--------------------------------------
3
PsiBlast_PDB
79.65
27%
-32
- C4 -
-
3W0O
2
KHYB_ECOLX
A:
[28-274]
------------------------------
L
S
E
G
E
E
S
R
A
F
S
F
D
V
G
G
R
G
Y
V
L
R
V
--
N
-
S
C
A
-----
D
G
F
Y
K
D
R
-
Y
V
Y
R
H
---
F
A
S
----
A
A--
L
P
I
P
E
V
L
D
I
G
---
E
-
F
---
S
E
S
L
T
Y
C
I
S
R
R
A
Q
G
-
V
T
L
Q
D
--
L
-----
P
-----
E
T
E
L
P
A
V
L
Q
P
V
A
E
----
V
M
D
A
I
A
A
-
A
D
L
S
Q
T
S
G
F
G
P
F
G
P
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
C
A
-
I
A
D
P
H
V
-
Y
H
W
Q
T
V
M
--
D
D
T
V
S
A
S
V
A
Q
A
L
D
E
L
M
L
W
A
E
D
C
-
P
E
V
--
R
H
L
V
--
H
A
D
F
G
S
N
N
V
L
T
D
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
---------------------
F
F
W
R
P
W
L
--
A
C
M
E
Q
Q
A
R
Y
F
E
-
R
R
H
P
E
L
--
A
---
G
S
--
P
---------
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
------------------------------------------
4
PsiBlast_PDB
79.27
27%
-31
- C4 -
-
3W0R
2
KHYB_ECOLX
A:
[28-274]
------------------------------
L
S
E
G
E
E
S
R
A
F
S
F
D
V
G
G
R
G
Y
V
L
R
V
--
N
-
S
C
A
-----
D
G
F
Y
K
D
R
-
Y
V
Y
R
H
---
F
A
S
----
A
A--
L
P
I
P
E
V
L
D
I
G
---
E
-
F
---
S
E
S
L
T
Y
C
I
S
R
R
A
Q
G
-
V
T
L
Q
D
--
L
-----
P
-----
E
T
E
L
P
A
V
L
Q
P
V
A
E
----
V
M
D
A
I
A
A
-
A
D
L
S
Q
T
S
G
F
G
P
F
G
P
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
C
A
-
I
A
D
P
H
V
-
Y
H
W
Q
T
V
M
--
D
D
T
V
S
A
S
V
A
Q
A
L
D
E
L
M
L
W
A
E
D
C
-
P
E
V
--
R
H
L
V
--
H
A
D
F
G
S
A
N
V
L
T
D
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
---------------------
F
F
W
R
P
W
L
--
A
C
M
E
Q
Q
A
R
Y
F
E
-
R
R
H
P
E
L
--
A
---
G
S
--
P
---------
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
------------------------------------------
6
PsiBlast_PDB
79.17
26%
-29
- C4 -
-
3W0Q
2
KHYB_ECOLX
A:
[28-274]
------------------------------
L
S
E
G
E
E
S
R
A
F
S
F
D
V
G
G
R
G
Y
V
L
R
V
--
N
-
S
C
A
-----
D
G
F
Y
K
D
R
-
Y
V
Y
R
H
---
F
A
S
----
A
A--
L
P
I
P
E
V
L
D
I
G
---
E
-
F
---
S
E
S
L
T
Y
C
I
S
R
R
A
Q
G
-
V
T
L
Q
D
--
L
-----
P
-----
E
T
E
L
P
A
V
L
Q
P
V
A
E
----
V
M
D
A
I
A
A
-
A
D
L
S
Q
T
S
G
F
G
P
F
G
P
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
C
A
-
I
A
D
P
H
V
-
Y
H
W
Q
T
V
M
--
D
D
T
V
S
A
S
V
A
Q
A
L
D
E
L
M
L
W
A
E
D
C
-
P
E
V
--
R
H
L
V
--
H
A
D
F
G
S
N
A
V
L
T
D
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
---------------------
F
F
W
R
P
W
L
--
A
C
M
E
Q
Q
A
R
Y
F
E
-
R
R
H
P
E
L
--
A
---
G
S
--
P
---------
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
------------------------------------------
56
Fugue
63.99
13%
-4
- C4 -
-
3HAM
3
?
A:
[1-299]
-M
V
N
L
D
A
E
I
Y
E
H
L
N
K
Q
----
I
--
K
I
N
E
L
R
Y
L
S
S
G
D
D
S
D
T
F
L
C
N
E
Q
Y
V
V
K
V
P
K
R
--
D
-
S
V
R
-----
I
S
Q
K
R
E
F
-
E
L
Y
R
F
---
L
E
N
----
C
KLS
Y
Q
I
P
A
V
V
Y
Q
S
---
D
-
R
---
F
N
I
M
K
Y
I
K
G
E
R
I
T
Y
-
E
Q
Y
H
K
--
L
-----
S
-----
E
K
E
K
D
A
L
A
Y
D
E
A
T
----
F
L
K
E
L
H
S
-
I
E
I
D
-----
C
S
V
S
L
F
--
S
-----
D
A
L
V
N
K
K
D
K
F
L
Q
D
-
K
K
L
L
I
S
I
L
E
K
E
Q
--
L
L
T
D
E
M
L
E
H
I
E
T
I
Y
E
N
I
L
N
N
A
V
L
F
-
K
Y
T
--
P
C
L
V
--
H
N
D
F
S
A
N
N
M
I
F
R
N
----
N
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
L
L
D
C
-----------
S
T
D
DFG
K
E
F
G
R
K
V
L
--
K
--------
Y
Y
-
Q
H
K
--
A
--
P
---
E
V
A
E
R
---------
K
A
E
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
E
R
---
K
D
---------
R
E
M
L
I
K
G
V
S
E
L
L
Q
T
Q
A
E
M
F
I
F
-
34
HHSearch
58.86
13%
-4
* C4 *
-
3TDW
1
?
A:
[4-300]
-----
N
K
L
H
Y
T
T
M
I
M
T
Q
F
PD
I
--
S
I
Q
S
V
E
S
L
G
E
G
F
R
N
Y
A
I
L
V
N
---
G
D
W
V
F
R
F
--
P
-
K
S
Q
Q
G
A
--
D
E
L
N
K
E
I
-
Q
L
L
P
L
---
L
V
G
CV--
K
---
V
N
I
P
Q
Y
V
Y
I
G
---
K
R
S
---
D
G
-
N
P
F
V
G
Y
R
K
V
Q
G
-
Q
I
L
G
E
--
D
-----
G
M
A
V
LP
D
D
A
K
D
R
L
A
L
Q
L
A
E
----
F
M
N
E
L
S
A
-
F
P
V
E
T
A
I
S
A
G
V
P
--------------
V
T
N
L
K
N
K
I
L
L
-
L
S
E
A
V
E
D
Q
-
V
F
P
L
L
D
E
--
S
L
R
D
Y
L
T
L
R
F
Q
S
Y
M
T
H
P
V
Y
T
-
R
Y
T
--
P
R
L
I
--
H
G
D
L
S
P
D
H
F
L
T
N
L
NSRQ
T
P
L
T
G
I
I
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
V
Y
L
L
---------------------
E
D
C
G
E
L
--
F
T
-------
R
Q
V
M
A
Y
R
G
E
VD
L
---
D
T
H
I
R
---------
K
V
S
L
F
V
T
F
D
Q
V
S
Y
L
L
E
G
L
R
A
RD
Q
D
W
I
S
E
G
-----
L
E
L
L
E
E
D
K
A
N
N
-----------
63
Fugue
57.16
12%
-50
- C4 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
--
T
D
I
T
E
D
E
L
R
N
F
L
T
Q
----
Y
--
D
V
G
S
L
T
S
Y
K
G
I
A
E
N
S
N
F
L
L
H
T
T
K
D
P
L
I
L
T
L
Y
E
K
-
K
N
D
-----
L
P
F
F
L
G
L
M
Q
H
L
A
A
---
K
G
L
----
S
---
C
P
L
P
L
P
R
K
D
G
EL
L
G
-
E
---
L
S
G
R
P
A
A
L
I
S
F
L
E
G
M
W
L
-
R
K
--
P
-----
E
-----
A
K
H
C
R
E
V
G
K
A
L
A
-----------
A
M
H
L
A
S
E
G
F
E
I
K
R
P
N
A
L
--
S
-----
V
D
G
W
K
V
L
W
D
K
S
E
E
-
R
A
D
E
--------------
V
E
K
G
L
R
E
E
I
R
P
E
I
D
Y
L
A
A
H
W
-
P
K
D
LP
A
G
V
I
--
H
A
D
L
F
Q
D
N
V
F
F
L
G
----
D
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
A
WCFEKDGAYN
V
T
K
G
---
K
A
L
L
E
G
Y
Q
--
S
--------
V
R
-
P
L
S
E
A
E
--
L
---
E
A
L
P
L
---------
L
S
R
G
S
A
L
R
F
F
L
T
R
L
Y
D
W
L
T
T
---
P
A
G
A
L
V
VKKD
P
L
E
Y
L
R
K
L
R
F
H
R
T
I
A
N
V
A
E
Y
G
L
A
16
PsiBlast_PDB
56.76
21%
-13
- C4 -
-
3Q2J
1
KKA3_ENTFL
A:
[4-222]
--
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
--
V
--
K
D
T
E
-----
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
L
Y
L
K
M
--
T
D
S
R
Y
-----
K
G
T
T
Y
D
V
-
E
R
E
K
D
M
M
L
W
L
E
G---
K
---
L
P
V
P
K
V
L
-
H
F
---
E
-
R
---
H
D
G
W
S
N
L
L
M
S
E
A
D
G
---
V
L
C
--
S
-----
E
-----
E
Y
E
D
E
Q
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
-
I
D
I
S
D
C
P
Y
T
N
S
L
D
S
R
--------------
L
A
E
L
D
Y
L
-
L
N
N
D
L
A
D
V
D
C
E
N
W
--
E
E
D
T
P
F
K
D
P
R
E
L
Y
----
D
F
L
K
T
E
-
K
P
E
--
E
E
L
V
FS
H
G
D
L
G
D
S
N
I
F
V
K
D
----
G
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
56.73
14%
9
- C4 -
-
3JR1
3
?
A:
[18-309]
---
Q
G
M
W
K
S
I
S
Q
V
L
A
E
Q
F
G-
A
Y
Y
F
I
K
H
K
E
K
L
Y
S
G
E
M
N
E
I
W
L
I
N
D
E
V
Q
T
V
F
V
K
I
--
N
-
E
R
S
Y
R
---
S
M
F
R
A
E
A
-
D
Q
L
A
L
---
L
A
K
T
N--
S
---
I
N
V
P
L
V
Y
G
I
G
---
N
-
S
---
Q
G
-
H
S
F
L
L
L
E
A
L
N
K
-
S
K
N
K
-------------------
Q
S
S
F
T
I
F
A
E
----
K
I
A
Q
L
H
Q
-
I
Q
G
P
D
K
--
Y
G
L
D
F
D
T
W
L
G
P
I
Y
Q
P
N
D
W
Q
T
S
W
A
K
F
F
S
E
N
R
I
G
W
Q
L
-----
Q
I
C
K
E
K
G
L
I
F
G
N
I
D
L
I
V
Q
I
V
A
D
T
L
S
K
H
-
N
P
K
--
P
S
I
L
--
H
G
N
L
W
I
E
N
C
I
Q
V
D
----
D
K
-
I
F
V
C
N
P
-
A
C
Y
W
G
D
R
E
C
D
I
A
F
S
S
---------------------
L
F
E
P
F
P
--
T
--------
N
F
Y
Q
R
Y
N
E
I
--
Y
P
L
E
E
G
Y
L
E
---------
R
K
L
I
Y
Q
L
Y
Y
L
L
N
F
S
Y
R
Y
Y
N
K
KQ-
S
Y
V
S
L
T
-----
Q
K
L
I
N
Q
I
L
H
K
------------
55
Fugue
56.43
17%
10
- C4 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
AK
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
--
V
--
K
D
T
E
-----
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
L
Y
L
K
M
--
T
-
D
S
R
YKGTT
Y
D
V
E
R
E
K
-
D
M
M
L
W
---
L
E
G
----
K
---
L
P
V
P
K
V
L
H
F
E
---
R
-
H
----
D
G
W
S
N
L
L
M
S
E
A
D
G
-
V
L
C
S
E
E
Y
E
-----
D
-----
E
Q
S
P
E
K
I
I
E
L
Y
A
E
----
C
I
R
L
F
H
S
-
I
D
I
S
D
C
P
-------------------
Y
T
N
S
L
D
S
R
L
A
-
E
L
D
Y
L
L
N
N
D
L
A
D
V
D
C
E
N
W
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
F
L
K
T
E
K
P
E
E
E
--
L
V
F
S
--
H
G
D
L
G
D
S
N
I
F
V
K
D
----
G
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
-----------
I
R
E
---
D
I
G
E
E
Q
Y
V
--
E
--------
L
F
-
F
D
L
L
G
I
--
K
---
P
D
-
W
E
---------
K
I
K
Y
Y
I
L
L
D
E
L
F
--------------------------------------------
49
HHSearch
56.20
14%
-7
- C4 -
-
5IQC
2
AACA_STAAU
A:
[10-285]
----
T
N
V
K
A
M
K
Y
L
I
E
H
Y
F
DN
F
--
K
V
D
S
I
E
I
I
G
S
G
Y
D
S
V
A
Y
L
V
N
---
N
E
Y
I
F
K
T
--
K
-
F
S
T
NKK--
K
G
Y
A
K
E
K
-
A
I
Y
N
F
---
L
N
T
N
LET
N
---
V
K
I
P
N
I
E
Y
S
Y
---
I
-
S
---
D
E
-
L
S
I
L
G
Y
K
E
I
K
G
-
T
F
L
T
P
--
E
I
Y
S
T
M
S
-----
E
E
E
Q
N
L
L
K
R
D
I
A
S
----
F
L
R
Q
M
H
G
-
L
D
Y
T
D
I
S
E
C
T
I
D
-------------
N
K
Q
N
V
L
E
E
Y
I
L
-
L
R
E
T
-----
I
Y
N
D
L
T
D
--
I
E
K
D
Y
I
E
S
F
M
E
R
L
N
A
T
T
-
V
F
-
E
G
K
--
K
C
L
C
--
H
N
D
F
S
C
N
H
L
L
L
D
G
N---
N
R
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
I
Y
L
L
E
D
-----------
S
------
E
E
E
I
G
T
N
F
G
E
--------
D
I
L
R
M
Y
G
N
I
D-
I
---
E
K
A
K
E
---------
Y
Q
D
I
V
E
E
Y
Y
P
I
E
T
I
V
Y
G
I
K
N
------------------------------------
50
HHSearch
55.42
13%
-1
- C4 -
-
5IQI
1
AACA_STAAU
C:
[9-285]
---
A
T
N
V
K
A
M
K
Y
L
I
E
H
Y
F
DN
F
--
K
V
D
S
I
E
I
I
G
S
G
Y
D
S
V
A
Y
L
V
N
---
N
E
Y
I
F
K
T
--
K
-
F
S
T
NKK--
K
G
F
A
K
E
K
-
A
I
Y
N
F
---
L
N
T
N
LET
N
---
V
K
I
P
N
I
E
Y
S
Y
---
I
-
S
---
D
E
-
L
S
I
L
G
Y
K
E
I
K
G
-
T
F
L
T
P
--
E
-----
I
Y
S
T
MS
E
E
E
Q
N
L
L
K
R
D
I
A
S
----
F
L
R
Q
M
H
G
-
L
D
Y
T
D
I
S
E
C
T
----------------
I
D
N
K
Q
N
V
L
E
E
-
Y
I
L
L
R
E
T
--
I
Y
N
D
L
T
D
--
I
E
K
D
Y
I
E
S
F
M
E
R
L
N
A
T
T
-
V
F
-
E
G
K
--
K
C
L
C
--
H
N
D
F
S
C
N
H
L
L
L
D
G
N---
N
R
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
I
Y
L
L
E
D
-----------
S
------
E
E
E
I
G
T
N
F
G
E
--------
D
I
L
R
M
Y
G
N
I
D-
I
---
E
K
A
K
E
---------
Y
Q
D
I
V
E
E
Y
Y
P
I
E
T
I
V
Y
G
I
K
N
------------------------------------
37
HHSearch
55.27
16%
-11
- C- -
-
3N4U
-
?
A:
[3-282]
---
T
Y
T
F
D
Q
V
E
K
A
I
E
Q
L
Y
P-
D
F-
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
I
---
N
R
D
F
I
F
K
F
--
P
-
K
H
S
R
G
S
--
T
N
L
F
N
E
V
-
N
I
L
K
R
---
I
H
N
KL--
P
---
L
P
I
P
E
V
V
F
T
G
---
M
-
P
S
ET
Y
Q
-
M
S
F
A
G
F
T
K
I
K
G
-
V
P
L
T
P
--
L
-----
L
L
N
N
LP
K
Q
S
Q
N
Q
A
A
K
D
L
A
R
----
F
L
S
E
L
H
S
-
I
N
I
S
G
F
K
---
S
N
-------------
L
V
L
D
F
R
E
K
I
N
E
-
D
N
K
K
I
K
K
L
-
L
S
R
E
L
K
G
--
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
N
E
I
Y
F
-
K
Y
Y
--
P
C
L
I
--
H
N
D
F
S
S
D
H
I
L
F
D
T
EK--
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
M
E
D
-----------
D
-------
E
E
Y
G
M
E
F
V
S
--------
K
I
L
N
H
Y
K
H
K
--
D
I
--
P
T
V
L
E
---------
K
Y
R
M
K
E
K
Y
W
S
F
E
K
I
I
Y
G
K
E
Y
------------------------------------
14
PsiBlast_PDB
53.92
21%
-9
- C4 -
-
1J7L
1
KKA3_ENTFL
A:
[4-222]
--
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
--
V
--
K
D
T
E
-----
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
L
Y
L
K
M
--
T
D
S
R
Y
-----
K
G
T
T
Y
D
V
-
E
R
E
K
D
M
M
L
W
L
E
G---
K
---
L
P
V
P
K
V
L
-
H
F
---
E
-
R
---
H
D
G
W
S
N
L
L
M
S
E
A
D
G
---
V
L
C
--
S
-----
E
-----
E
Y
E
D
E
Q
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
-
I
D
I
S
D
C
P
Y
T
N
S
L
D
S
R
--------------
L
A
E
L
D
Y
L
-
L
N
N
D
L
A
D
V
D
C
E
N
W
--
E
E
D
T
P
F
K
D
P
R
E
L
Y
----
D
F
L
K
T
E
-
K
P
E
--
E
E
L
V
FS
H
G
D
L
G
D
S
N
I
F
V
K
D
----
G
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
53.75
21%
-6
- C4 -
-
1J7U
1
KKA3_ENTFL
A:
[4-222]
--
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
--
V
--
K
D
T
E
-----
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
L
Y
L
K
M
--
T
D
S
R
Y
-----
K
G
T
T
Y
D
V
-
E
R
E
K
D
M
M
L
W
L
E
G---
K
---
L
P
V
P
K
V
L
-
H
F
---
E
-
R
---
H
D
G
W
S
N
L
L
M
S
E
A
D
G
---
V
L
C
--
S
-----
E
-----
E
Y
E
D
E
Q
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
-
I
D
I
S
D
C
P
Y
T
N
S
L
D
S
R
--------------
L
A
E
L
D
Y
L
-
L
N
N
D
L
A
D
V
D
C
E
N
W
--
E
E
D
T
P
F
K
D
P
R
E
L
Y
----
D
F
L
K
T
E
-
K
P
E
--
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
----
G
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
------------------------------------------------------------------------------------------------------------------------------