@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : A9GMF3_SORC5: (2019-01-26 )
MTRDALDRAAVTAFLVARHGDAVCDSAIEIRPLPGGLCSEVALVTARLRGAAGARRVTLVAKLVHGTAAREAAVYRRLSRSVGRRFSPELLGAERLGRGRWLLYLERIEPAHAWPWADSGHTARVLERLARLHEETPQGAALPAWDYEAENLAMARDTLSLAERLPRGEVPALARALPALRRVVSALPAMRRQLLAFQPLGRAVIHGDVHPGNVMVRRRDGVVEPVLLDWARARMGSPLEDVSSWLQALGYWEPEARRRHDTLLAGYLSARGLPPALTRPLRDVYWFASASNALAGALGHHLAMACGASAPGVLAAAARNAADWLRVIRRADACWS
Atome Classification :
(22 SA)
--------------.........10........20--..---...---....30........40..-..---....50-........60-----.-..--.-----.-----...----------.70........80.-.....-...90.....----------..------.100--.........---110.-....-----.-------------.----------------.-120....-...130.......-------------.140...-...----.150-.-...-.-...160------...-----..----.-.170---......-----...180.......190.....---...200-.......210.....-..220---........230.......240..-..----------------...----------250.-----------------.-...----...--------------260.-....--..270--.......280--.........290-.......300.......310--.....---...320.......330....---------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------M
T
R
D
A
L
D
R
A
A
V
T
A
F
L
V
ARHG---DA---VCD---S
A
I
E
IRPLPG
G
L
C
S
E
V
A
L
-
V
T
---
A
R
LRGA-AGA
R
R
V
T
L
V
------
A
-
K
L
--
V
-----H-----GT
A
----------
A
R
E
A
A
V
Y
R
R
L
S
R
-
S
-VGRRF-
S
P
E
L
L
G
A
E
R
L----------GR------G
R
----
W
L
L
Y
L
E
RIE---P-AH-AWPW-----A-------------D----------------S-G
H
T
A
R
V
L
-
E
R
L
A
R
-
L
H
EETPQ-------------GAALPAW-DYE----A
E
-
N
-
L
-
A
M
A
-
R
-
D
T
L
S
L
A
------
E
RL-----PR----G-E
V
-----
P
A
L
A
R
A
-----
L
P
A
L
R
R
V
V
S
A
L
P
A
M
-
R
R
Q
L
L
A
---FQPLG
R
-
A
V
I
HGDVHPG
N
V
M
V
R
-RRDG----VV
E
P
V
L
L
D
W
A
R
A
RMGS
P
L
E
D
V
S
S
-
W
L
----------------
Q
AL----------GY-W-----------------
E
-
P
E
A
----
R
R
R
--------------
H
D
T
L
-
L
A
G
Y
--
L
S
ARG--L
P
P
A
L
T
R
P
----
L
R
D
V
Y
W
FASA
S
N
-
A
L
A
G
A
L
G
H
H
L
A
M
ACGASA
P
---
G
V
L
A
A
---
A
A
R
N
A
A
D
W
L
R
V
I
R
RADACWS---------------------
30
Fugue
79.74
15%
-31
- C3 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
------------------
T
L
P
A
V
I
S
R
W
L
S
S
V
L
P
G
---
G
A
---
A
P
E
---
V
T
V
E
S
G
V
D
S
T
G
M
S
S
E
T
I
I
-
L
T
---
A
R
W
Q
Q
D
-
G
R
S
I
Q
Q
K
L
V
------
A
-
R
V
--
A
-----
P
-----
A
A
E
DVPVFPTYR
L
D
H
Q
F
E
V
I
R
L
V
G
E
-
L
-
T
D
V
P
V
-
P
R
V
R
W
I
E
T
T
G
----------
D
V
L-----
G
T
----
P
F
F
L
M
D
Y
V
E
G
V
V
P
-
P
D
-
V
M
P
Y
-----
T
FGDNWFADAP
A
E
R
Q
----------------
R
-
Q
L
Q
D
A
T
V
-
A
A
L
A
T
-
L
H
S
I
P
N
A
-------------
Q
N
T
F
S
F
L
T
D
T
T
----
L
H
-
R
-
H
-
F
N
W
-
V
-
R
S
W
Y
D
F
------
A
V
E
-----
G
I
----
G
-
R
S
-----
P
L
L
E
R
T
-----
F
E
W
L
Q
S
H
W
P
D
D
A
A
A
-
R
E
P
-------------
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
-
D
F
-------
Q
P
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
W
-
M
I
----------------
F
A
H
----------
R
V
-
F
-----------------
Q
-
E
L
A
----
G
L
A
--------------
T
L
P
G
-
L
P
E
V
--
M
R
E
D
D
--
V
R
A
T
Y
Q
A
L
TG
V
E
L
G
D
L
H
W
F
Y
V
Y
S
G
-
V
M
W
A
C
V
F
M
R
T
G
A
R
R
V
H
F
G
E
---
I
E
K
P
D
---
D
V
E
S
L
F
Y
H
A
G
L
M
K
H
L
L
G
E
E
H
---------------------
39
Fugue
79.49
16%
-31
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
-----------------
T
D
I
T
E
D
E
L
R
N
F
L
T
Q
Y
D
V
---
G
S
---
L
T
S
---
Y
K
G
I
A
E
N
S
N
F
L
L
H
T
T
K
D
P
-
L
I
---
L
T
L
Y
E
K
-
K
N
D
L
P
F
F
L
G
------
L
M
Q
H
--
L
-----
A
-----
A
K
G
----------
L
S
C
P
L
P
L
P
R
K
D
G
-
E
-
L
L
G
E
L
-
S
---------------------------
G
R
----
P
A
A
L
I
S
F
L
E
---
G
M
W
L
-
R
K
P
--------------------
E
----------------
A
-
K
H
C
R
E
V
G
-
K
A
L
A
A
M
H
L
A
S
E
G
F
-------------
E
I
K
R
P
N
A
-
L
S
V
----
D
G
-
W
-
K
-
V
L
W
-
D
-
K
S
E
E
R
A
------
D
E
V
-----
E
K
----
G
-
L
R
-----
E
E
I
R
P
E
-----
I
D
Y
L
A
A
H
W
P
----------------
K
D
L
P
A
-
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
----
G
----
D
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
-
C
L
----------------
N
A
W
----------
C
F
-
E
-----------------
K
-
D
G
A
YN--
V
T
K
--------------
G
K
A
L
-
L
E
G
Y
--
Q
S
V
R
P
--
L
S
E
A
E
L
E
A
----
L
P
L
L
S
R
G
S
A
L
R
F
-
F
L
T
R
L
Y
D
W
L
T
T
P
A
G
A
L
V
V
K
---
K
D
P
L
E
---
Y
L
R
K
L
R
F
H
R
T
I
A
N
V
A
E
Y
G
L
A
---------------------
44
HHSearch
78.00
19%
-37
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-263]
-----------------
T
D
I
T
E
D
E
L
R
N
F
L
T
Q
-
Y
D
---
V
----
G
-----
S
L
T
S
Y
K
G
I
A
E
---
N
S
N
F
L
-
L
H
---
T
T
K
---------
D
P
L
I
------
L
-
T
L
Y
-
E
K----
K
-----
N
D
L
----------
P
F
F
L
G
L
M
Q
H
L
A
A
-
K
---
G
L
S
-
C
P
L
P
L
P
R
K
D
G
EL
L
G
E
-----
L
S
------
G
R
----
P
A
A
L
I
S
F
L
E
-----
G
M
-
W
L
R
K
-----
P
-------------
E
----------------
A
-
K
H
C
R
E
V
G
-
K
A
L
A
A
-
M
H
L
A
S
E
G
-------------
F
E
I
K
-
R
P
-
N
------
A
------
L
S
V
-
D
-
G
W
K
V
L
W
------
D
K
S
-----
E
E
RA--
D
-
E
V
-----
E
K
G
L
R
----------
E
E
I
R
P
E
I
D
Y
L
-
A
A
H
--
W
---
P
K
D
L
P
A
-
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
-
G
-
D
------
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
-
C
L
----------------
N
A
W
----------
C
F
-
E
KDGAY------------
N
-
V
T
K
----
G
K
A
-----------------
L
-
L
E
G
Y
--
Q
S
V
R
P
--
L
S
E
A
E
L
E
-----------------------------------------------------------------------------------------
41
Fugue
75.20
17%
10
- C3 -
-
3CSV
11
?
A:
[4-333]
--------------------
S
R
E
D
E
I
R
D
F
L
A
T
H
G
---
Y
A
---
D
W
N
---
R
T
P
R
Y
Q
R
L
R
S
P
T
G
A
K
A
V
L
M
D
W
---
S
P
E
E
G
G
-
D
T
Q
P
F
V
D
L
A
------
Q
-
Y
L
--
R
-----
N
-----
L
D
I
------------------
S
A
P
E
-
I
-
Y
A
E
E
H
-
A
R
G
L
L
L
I
E
D
L
----------
G
D
------
A
L
----
F
T
E
V
I
N
N
D
P
---
A
-
Q
------------------------------------------
E
M
P
L
Y
R
A
A
V
-
D
L
L
I
H
-
L
H
D
A
Q
T
P
-------------
E
L
A
R
L
D
P
-
E
T
L
----
S
E
M
T
-
R
-
L
A
F
-
S
-
E
----------------------------------
Y
R
Y
A
I
L
-----
G
D
A
A
E
D
N
R
K
R
F
E
H
R
-
F
A
Q
I
L
S
---
A
Q
L
E
G
D
M
V
F
V
H
R
D
F
H
A
Q
N
L
L
W
L
P
E
R
E
G
----
L
A
R
V
G
V
I
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
V
S
-
L
L
----------------
Q
D
A
-------------------------------
R
-
R
D
V
----
P
A
Q
--------------
V
E
A
Q
M
I
D
H
Y
--
I
Q
A
T
G
--
V
D
---
E
S
H
----
F
R
S
A
Y
A
V
I
A
V
Q
R
-
N
M
-
R
I
L
G
I
F
A
R
L
S
Q
R
F
G
K
R
---
H
Y
I
E
F
---
V
P
R
V
W
A
H
F
E
R
G
L
A
H
P
A
L
A
S
A
A
E
E
I
L
N
A
L
PAPA
P
E
V
L
E
R
L
R
A
31
Fugue
74.58
13%
-1
- C3 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
------------SA
F
T
F
Q
T
L
H
P
D
T
I
M
D
A
L
F
E
H
G
I
---
R
----------
V
D
S
G
L
T
P
L
N
S
Y
E
N
R
V
Y
Q
F
-
Q
D
-------
E
D
-
R
R
R
F
V
V
K
F
Y
RP----
E
-
R
W
--
T
-----
A
-----
D
Q
I
----------
L
E
E
H
Q
F
A
L
Q
L
V
N
-
D
-
E
V
P
V
A
-
A
P
V
A
F
N
G
Q
T
L
----------
L
N
H
-----
Q
G
----
F
Y
F
A
V
F
P
S
V
---
G
-
G
R
-
Q
F
E
A
-----
D
-------------
N
----------------
I
-
D
Q
M
E
A
V
G
-
R
Y
L
G
R
-
M
H
Q
T
G
R
K
-------------
Q
L
F
I
H
R
P
-
T
I
G
----
L
N
-
E
-
Y
L
I
E
P
-
R
-
K
L
F
E
D
A
------
T
L
I
-----
P
S
----
G
-
L
K
-----
A
A
F
L
K
A
-----
T
D
E
L
I
A
A
V
T
A
H
W
R
------------
E
D
F
T
V
-
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
-
D
G
P
M
----
F
V
-----
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
--------------------
M
L
L
----------
N
G
-
D
-----------------
K
-
A
E
Q
----
R
M
Q
--------------
L
E
T
I
-
I
E
A
Y
--
E
E
F
S
E
--
F
D
T
A
E
I
G
L
----
I
E
P
L
R
A
M
R
L
V
Y
Y
-
L
A
W
L
M
R
R
W
A
D
P
---
A
F
P
K
N
---
F
P
W
L
T
---
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
EPPLQLTPMY-----------
66
HHSearch
74.37
15%
-8
- C3 -
-
5FTG
11
CHKA_HUMAN
A:
[4-309]
----------------
P
E
P
R
T
R
R
R
A
Y
L
W
C
K
E
F
L
P
---
G
A
---
W
R
G
LRE
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
-
C
S
---
L
P
D
T
T
A
T
L
G
D
E
P
R
K
V
L
------
L
-
R
L
YG------------
E
A
M
----------
V
L
E
S
V
M
F
A
I
L
A
E
-
R
---
S
L
G
--
P
K
L
Y
G
I
F
P
-------------------------
Q
G
R
L
E
Q
F
I
P
-----
S
R
-
R
L
D
T
-----
E
-------------
E
LSL-------------
P
-
D
I
S
A
E
I
A
-
E
K
M
A
T
-
F
H
G
M
K
M
P
-------------
F
N
K
E
P
K
----------
W
-
L
-
F
-
G
T
M
-
E
-
K
Y
L
K
E
V
------
L
R
I
-----
K
F
----
T
-
E
E
S
R
---
I
K
K
L
H
K
------
L
L
S
Y
N
L
P
L
E
L
E
N
L
-
R
S
L
-
L
E
---
S
T
P
S
P
V
-
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
-
E
-
G
R
ENSE
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
-
H
F
----------------
C
E
W
----------
M
Y
-
D
YSYEKYPF
F
R
A
N
IRKYP
T
-
K
K
Q
----
Q
L
H
-----------------
F
-
I
S
S
Y
--
L
P
A
F
Q
--
N
-----------------------------------------------------------------------------------------------
28
Fugue
73.69
12%
-17
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
MDLDTD
A
N
T
I
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
GAW
K
T
---
V
P
L
---
E
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
-
C
R
L
S
E
V
Y
P
P
I
R
-
N
E
P
N
K
V
L
L
R
------
V
-
Y
F
--
N
-----
P
-----
E
T
E
----------
S
H
L
V
A
E
S
V
I
F
T
L
-
L
-
S
E
R
H
L
-
G
P
K
L
Y
G
--
I
F
----------
S
G
------
G
R
----
L
E
E
Y
I
P
S
R
P
---
L
-
S
C
-
H
-
E
I
-----
S
-------------
L
----------------
A
-
H
M
S
T
K
I
A
-
K
R
V
A
K
-
V
H
Q
L
E
V
P
-------------
I
W
K
E
P
D
--
Y
L
C
----
E
A
-
L
-
Q
-
R
W
L
-
K
-
Q
L
T
G
T
V
------
D
A
E
-----
H
R
----
F
-
D
L
-----
P
E
E
C
G
V
-----
S
S
V
N
C
L
D
L
A
R
E
L
E
F
-
L
R
A
H
I
S
---
L
S
K
S
P
V
-
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
-
K
R
---------
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
-
H
F
----------------
I
E
W
T
IDYDIDEAP
F
Y
-
K
-----------------
I
-
Q
T
E
NFPE
N
D
Q
--------------
M
L
E
F
-
F
L
N
Y
--
L
R
E
Q
G
NT
R
E
N
E
L
Y
K
K
----
S
E
D
L
V
Q
E
T
L
P
F
V
-
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
---
V
G
F
G
F
---
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA-------------------
29
Fugue
70.79
10%
-20
- C3 -
-
3I1A
2
?
A:
[3-330]
----------------
K
Q
P
I
Q
A
Q
Q
L
I
E
L
L
K
V
H
Y
G
---
I
D
---
I
-----
H
T
A
Q
F
I
Q
G
G
A
D
T
N
A
F
A
Y
Q
-
A
D
---
S
E
-----
S
K
S
Y
F
I
K
L
K
------
Y
-
G
Y
--
H
-----
D
-----
E
I
N
----------
L
S
I
I
R
L
L
H
D
S
G
I
-
K
-
E
I
I
F
P
-
I
H
T
L
E
A
K
L
F
Q
----------
Q
L
------
K
H
----
F
K
I
I
A
Y
P
F
I
---
H
-
A
P
-
N
G
F
T
-----
Q
-------------
N
L
T
--------------
G
-
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
-
I
H
E
T
S
V
P
-------------
I
S
I
Q
Q
Q
L
-
R
K
E
----
I
Y
-
S
-
P
-
K
W
R
-
E
-
I
V
R
S
F
Y
------
N
Q
I
EFDNS
D
D
----
K
-
L
T
-----
A
A
F
K
S
F
-----
F
N
Q
N
S
A
A
I
H
R
L
V
D
T
-
S
E
K
L
S
K
K
IQ
P
D
L
D
K
Y
-
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
-
N
E
E
S
-------
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
-
I
G
----------------
G
G
V
----------
G
N
-------------------
V
-
W
N
K
----
P
H
E
--------------
I
Q
Y
F
-
Y
E
G
Y
GE
I
N
V
D
K
--
T
I
L
S
Y
Y
R
H
----
E
R
I
V
E
D
I
A
V
Y
G
Q
-
D
L
L
S
R
N
Q
N
-----------------
N
Q
---
S
R
L
E
S
F
K
Y
F
K
E
M
F
D
P
N
N
V
V
E
I
A
F
A
T
E---------------
65
HHSearch
69.98
15%
6
- C3 -
-
5FUT
10
CHKA_HUMAN
A:
[4-309]
----------------
P
E
P
R
T
R
R
R
A
Y
L
W
C
K
E
F
L
P
---
G
A
---
W
R
G
LRE
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
-
C
S
---
L
P
D
T
T
A
T
L
G
D
E
P
R
K
V
L
------
L
-
R
L
YG-------G
A
---
E
A
M
----------
V
L
E
S
V
M
F
A
I
L
A
E
-
R
---
S
L
G
--
P
K
L
Y
G
I
F
P
-------------------------
Q
G
R
L
E
Q
F
I
P
-----
S
R
-
R
L
D
T
-----
E
-------------
E
LSL-------------
P
-
D
I
S
A
E
I
A
-
E
K
M
A
T
-
F
H
G
M
K
M
P
-------------
F
N
K
E
P
K
----------
W
-
L
-
F
-
G
T
M
-
E
-
K
Y
L
K
E
V
------
L
R
I
-----
K
F
----
T
-
E
E
S
R
---
I
K
K
L
H
K
------
L
L
S
Y
N
L
P
L
E
L
E
N
L
-
R
S
L
-
L
E
---
S
T
P
S
P
V
-
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
-
E
-
G
R
ENSE
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
-
H
F
----------------
C
E
W
----------
M
Y
-
D
YSYEKYPF
F
R
A
N
IRKYP
T
-
K
K
Q
----
Q
L
H
-----------------
F
-
I
S
S
Y
--
L
P
A
F
Q
--
N
-----------------------------------------------------------------------------------------------
45
HHSearch
69.46
16%
-11
- C3 -
-
6EF6
2
?
A:
[27-303]
---------------------
D
V
T
I
A
Q
Q
A
L
T
H
Y
D
---
V
----
S
-----
D
N
A
S
L
R
L
L
-
N
L
S
E
N
A
T
Y
L
-
V
E
---
D
G
E
---------
H
Q
S
I
------
L
-
R
V
H
-
R
Q
DYHQ
P
-----
H
E
I
----------
E
S
E
L
D
W
L
A
A
L
R
T
D
S
---
D
V
T
-
V
P
T
V
V
P
A
R
D
G
RR
V
V
T
V
D
P
A
D-
V
------
P
R
----
H
V
V
H
F
E
M
V
G
-----
G
A
-
E
P
D
E
-----
E
SL-----------
T
----------------
L
-
D
D
F
Q
T
L
G
-
R
I
T
A
S
-
L
H
E
H
S
Q
R
-------------
W
T
R
P
A
G
F
-
G
R
F
S
WDW
E
H
-
C
-
L
-
G
D
T
-
P
-
R
W
G
R
W
Q
------
D
A
------------
E
-
G
V
-----
G
A
S
E
T
A
-------
L
L
T
R
A
Q
D
L
L
H
R
K
-
L
E
E
-
Y
G
---
S
G
P
D
R
Y
-
G
L
I
H
A
D
L
R
L
A
N
L
L
V
D
-
S
-
S
T
P---
Q
R
T
I
T
V
I
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
G
T
-
A
V
----------------
S
F
I
----------
E
H
-
D
PR---------------
L
-
G
E
W
----
Q
E
S
-----------------
W
-
V
A
G
Y
--
R
S
R
R
E
--
L
P
A
A
D
E
A
M
----
L
-----------------------------------------------------------------------------------
49
HHSearch
69.45
14%
-44
- C3 -
-
3I1A
4
?
B:
[2-272]
---------------
L
K
Q
P
I
Q
A
Q
Q
L
I
E
L
L
K
V
H
Y
G
---
I
----------
D
I
H
T
A
Q
F
I
Q
G
G
A
D
T
N
A
F
A
-
Y
Q
---
A
D
S
E
---
S
----
K
S
Y
F
------
I
-
K
L
K
-
Y
-----
G
-----
Y
H
D
----------
E
I
N
L
S
I
I
R
L
L
H
D
-
S
---
G
I
K
E
I
I
F
P
I
H
T
L
E
A
KL
F
Q
Q
-----
L
K
------
H
F
----
K
I
I
A
Y
P
F
I
H
-----
A
P
-
N
G
F
T
-----
Q
N
L
-----------
T
----------------
G
-
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
-
I
H
E
T
S
V
P
-------------
I
S
I
Q
Q
Q
L
-
R
K
-----
E
I
-
Y
-
S
-
P
K
W
R
E
-
I
V
R
S
F
Y
------
N
Q
I
-----
E
F
DNSD
D
-
K
L
-----
T
A
A
F
K
S
F
F
N
Q
N
S
A
A
I
H
R
L
V
D
T
S
E
K
L
-
S
K
K
-
I
Q
---
P
D
L
D
K
Y
-
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
-
N
-
E
------
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
-
I
G
----------------
G
G
V
----------
G
N
V
W
-----------------
N
K
P
H
E
----
I
Q
Y
-----------------
F
-
Y
E
G
Y
--
G
E
I
N
V
--------------------------------------------------------------------------------------------------
70
SP3
68.49
11%
0
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
MDLDTD
A
N
T
I
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
---
G
A
WKT
V
P
L
---
E
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
-
C
R
---
L
S
E
V
Y
P
-
P
I
R
N
E
P
N
K
V
L
L
R
V
Y
F
N
-
P
E
--
T
-----
E
-----
S
H
L
----------
V
A
E
S
V
I
F
T
L
L
S
E
-
R
-
H
L
-
G
P
-
K
L
Y
G
I
F
S
G
---------------------------
G
R
L
E
E
Y
I
P
---
S
-
R
P
-
L
S
C
H
E
I
---
S
-------------
L
----------------
A
-
H
M
S
T
K
I
A
-
K
R
V
A
K
-
V
H
Q
L
E
V
P
-------------
I
W
------
K
E
P
----
D
Y
-
L
-
C
-
E
A
L
-
Q
-
R
W
L
K
Q
L
------
T
G
T
-----
V
D
----
A
-
E
H
R
F
D
L
P
E
E
C
G
V
S
-----
S
V
N
C
L
D
L
A
R
E
L
E
F
L
-
R
A
H
I
-
S
---
L
S
K
S
P
V
-
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
-
K
R
---------
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
-
H
F
----------------
I
E
W
----------
T
I
-
D
-----------------
Y
-
D
I
D
----
E
A
P
F
Y
K
I
Q
TENFPE
N
D
Q
M
L
E
F
-
F
L
N
Y
--
L
R
E
Q
G
NT
R
E
N
E
L
Y
K
K
----
S
E
D
L
V
Q
E
T
L
P
F
V
-
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
VGF
G
F
A
D
Y
---
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A
----------------------
63
HHSearch
63.63
19%
-13
- C3 -
-
5IGH
-
?
A:
[5-257]
-----------------
T
T
A
D
T
S
Q
L
Y
A
L
A
A
R
-
H
G
---
L
----
K
L
H
-----
G
P
L
T
V
N
E
L
G
L
D
Y
R
I
V
I
-
A
T
---
V
D
D
----
G
----
R
R
W
V
------
L
-
R
I
P
R
R
A
E
V
--
S
-----
A
K
V
----------
E
P
E
A
R
V
L
A
M
L
K
N
-
R
--
L
P
F
A
-
V
P
D
W
R
V
A
N
A
E
----------
L
V
------
A
Y
P
MLE
D
S
T
A
M
V
I
Q
P
-----
G
S
-
S
T
P
D
W
V
V
P
Q
D
-------------
S
----------------
E
-
V
F
A
E
S
F
A
-
T
A
L
A
A
-
L
H
A
V
P
I
S
-------------
A
A
V
D
A
G
M
-
L
I
-----
R
T
-
P
---
T
Q
A
R
Q
-
K
V
A
D
D
V
------
D
R
V
-----
R
-----
R
-
E
F
-----
V
-
V
N
D
K
-------
R
L
H
R
W
Q
R
W
L
D
D
D
-
S
--------
S
W
P
D
F
S
-
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
-
N
-
T
E
-----
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
-
H
L
----------------
M
V
--------------
F
-----------------
G
-
E
E
G
----
L
A
K
-----------------
L
-
L
L
T
Y
--
E
A
A
G
G
--
R
-----------------------------------------------------------------------------------------------
64
HHSearch
62.58
16%
-16
- C3 -
-
1ZYL
-
SRKA_ECOLI
A:
[9-263]
-----------------
Q
T
L
H
P
D
T
I
M
D
A
L
F
E
-
H
G
---
I
----
R
V
D
-----
S
G
L
T
P
L
-
N
S
Y
E
N
R
V
Y
Q
-
F
Q
---
D
E
D
----
R
----
R
R
F
V
------
V
-
K
F
Y
-
R
PERWT
A
-----
D
Q
I
----------
L
E
E
H
Q
F
A
L
Q
L
V
N
-
D
---
E
V
P
-
V
A
A
P
V
A
F
N
G
Q
T
L
L
N
------
H
Q
------
G
F
----
Y
F
A
V
F
P
S
V
G
-----
G
R
-
Q
F
E
A
-----
D
-------------
N
----------------
I
-
D
Q
M
E
A
V
G
-
R
Y
L
G
R
-
M
H
Q
T
G
R
K
-------------
Q
L
F
I
H
R
P
-
T
------
I
G
-
L
---
N
E
Y
L
I
-
E
P
R
K
L
F
------
E
D
A
-----------
T
-
L
I
-----
P
S
G
L
K
A
------
A
F
L
K
A
T
D
E
L
I
A
A
V
-
T
A
H
--
W
---
R
E
D
F
T
V
-
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
-
D
---------
G
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
-
L
L
----------------
N
G
D
----------
K
A
-
E
-----------------
Q
-
R
M
Q
----
L
E
T
-----------------
I
-
I
E
A
Y
--
E
E
F
S
E
--
F
D
T
A
E
I
------------------------------------------------------------------------------------------
46
HHSearch
62.22
18%
-28
- C3 -
-
5UXD
2
?
A:
[3-255]
-----------------
M
P
E
D
L
D
A
L
L
D
L
A
A
R
H
G
L
---
D
------
L
---
D
G
G
T
L
R
T
E
E
I
G
L
D
F
R
V
A
F
-
A
R
---
A
H
D
----
G
----
G
D
W
V
------
L
-
R
L
P
-
R
RPDV-
L
-----
E
R
A
----------
A
V
E
G
R
L
L
A
M
L
A
P
-
H
--
L
D
V
A
-
V
P
D
W
R
I
S
T
---------------------
S
----
E
L
I
A
Y
P
L
L
P
-----
G
S
-
P
G
L
T
-----
V
-------------
A
ADG
E
V
S
W
HVDMAS---
T
-
V
Y
A
R
S
L
G
-
S
V
V
A
Q
-
L
H
A
V
D
A
E
-------------
A
A
A
A
T
G
I
-
E
V
-----
R
S
-
P
---
A
Q
V
R
G
-
A
W
R
Q
D
L
------
A
R
V
-----
G
A
----
E
F
E
I
-----
A
P
A
----------
L
R
E
R
W
E
A
W
L
A
D
D
-
G
--------
C
W
P
G
H
S
-
V
L
T
H
G
E
L
Y
P
A
H
T
L
V
E
-
D
-
E
------
R
I
T
A
V
L
D
W
T
T
A
A
V
G
D
P
A
K
D
L
M
F
-
H
Q
----------------
V
------------
S
--
A
-----------------
P
-
S
A
I
----
F
E
V
-----------------
A
-
L
Q
A
Y
--
A
E
G
G
G
--
R
P
----------------------------------------------------------------------------------------------
33
Fugue
62.20
9%
-3
- C3 -
-
2Q83
5
COTI_BACSU
A:
[11-346]
--------------
L
S
A
E
D
A
K
K
L
T
E
L
A
E
N
V
L
Q
G
W
---
D
V
---
Q
A
E
---
K
I
D
V
I
Q
A
------------
L
V
---
W
K
V
H
T
D
-
S
G
A
V
C
L
K
R
I
------
H
-
R
P
--
E
-----
K
-----
K
A
L
----------
F
S
I
F
A
Q
D
Y
L
A
K
K
-
G
M
N
V
P
G
I
-
L
P
N
K
K
G
S
L
Y
S
----------
K
H
------
G
S
----
F
L
F
V
V
Y
D
W
I
---
E
-
G
R
-
P
F
E
L
-------------------
T
----------------
V
-
K
Q
D
L
E
F
I
M
K
G
L
A
D
-
F
H
T
A
S
V
G
Y
Q
P
P
NG
V
P
I
F
T
KL
G
R
W
P
N
H
Y
-
T
K
R
----
C
K
-
Q
M
E
-
T
W
K
-
L
M
A
E
A
E
K
E
------
D
P
F
-----
S
Q
----
L
-
Y
L
-----
Q
E
I
D
G
F
-----
I
E
D
G
L
R
I
K
D
R
L
L
Q
S
T
Y
V
P
W
T
E
---
Q
L
K
K
S
P
-
N
L
C
H
Q
D
Y
G
T
G
N
T
L
L
G
-
E
N
E
-------
Q
I
W
V
I
D
L
D
T
V
S
F
D
L
P
I
R
D
L
R
K
M
I
I
----------------
P
L
L
----------
D
T
-------------------
T
-
G
V
W
----
D
D
E
--------------
T
F
N
V
M
L
N
A
Y
--
E
S
R
A
P
--
L
T
E
E
Q
K
Q
V
M
---
F
---------
I
D
M
L
F
P
Y
E
L
Y
D
V
I
R
E
K
Y
V
R
K
S
A
---
L
P
K
E
E
---
L
E
S
A
F
E
Y
E
R
I
K
A
N
A
L
R
Q
L
I
----------------------
35
Fugue
61.07
12%
1
- C3 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
------------KT
P
L
Y
E
T
L
N
E
S
S
A
V
A
L
A
V
K
L
G
L
---
T
------------
L
T
C
Q
E
I
G
D
G
N
L
N
Y
V
F
H
-
I
Y
---
D
R
---
A
-
L
I
I
K
Q
A
V
P
Y
------
W
-
P
L
--
T
-----
I
-----
D
R
A
----------
R
I
E
S
S
A
L
I
R
Q
G
E
-
H
-
V
P
H
L
V
-
P
R
V
F
Y
S
D
T
E
M
----------
A
V
T
V
M
E
D
L
S
H
----
L
K
I
A
R
K
G
L
I
---
E
-
G
E
-
N
Y
P
H
-----
L
-------------
S
----------------
Q
-
H
I
G
E
F
L
G
-
K
T
L
F
Y
-
S
S
D
Y
A
L
E
-------------
P
K
V
K
K
Q
L
-
V
K
Q
----
F
T
-
N
-
P
-
E
L
C
-
D
-
I
T
E
R
L
V
FTDPFF
D
H
D
-----
T
N
----
D
-
F
E
-----
E
E
L
R
P
F
-----
V
E
K
L
W
N
N
D
S
V
K
I
E
A
-
A
K
L
K
K
S
---
F
L
T
S
A
E
-
T
L
I
H
G
D
L
H
T
G
S
I
F
A
S
-
E
H
--------
E
T
K
V
I
D
P
E
F
A
F
Y
G
P
I
G
F
D
V
G
Q
-
F
I
A
N
L
F
L
N
A
L
S
R
DGADR
E
P
L
Y
----------
E
H
-
V
-----------------
N
-
Q
V
W
----
E
T
F
--------------
E
E
T
F
-
S
E
A
W
--
Q
K
D
S
L
--
D
V
Y
A
N
I
D
G
----
Y
L
T
D
T
L
S
H
I
F
E
E
-
A
I
G
F
A
G
C
E
L
I
R
R
T
I
G
L
A
H
V
---
A
D
L
D
T
IVP
F
D
K
R
I
G
R
K
R
L
A
L
E
T
G
T
A
F
I
E
KRSEFKT
I
T
D
V
I
E
L
F
K
L
L
V
K-
47
HHSearch
60.38
17%
1
- C3 -
-
3CSV
8
?
A:
[4-256]
-------------------
S
R
E
D
E
I
R
D
F
L
A
T
-
H
G
----------
Y
---
A
D
W
N
R
T
P
--------
R
Y
Q
R
L
R
---
S
P
T
----
G
----
A
K
A
V
------
L
-
M
D
W
-
S
PEE--
G
-----
G
D
T
----------
Q
P
F
V
D
L
A
Q
Y
L
R
N
-
L
---
D
I
S
-
A
P
E
I
Y
A
E
E
H
-------------------
A
R
----
G
L
L
L
I
E
D
L
G
-----
D
A
-
L
F
T
E
-----
V
-------------
I
N
N
DPAQ
E
---------
M
-
P
L
Y
R
A
A
V
-
D
L
L
I
H
-
L
H
D
A
Q
T
P
-------------
E
L
A
--
R
L
-
D
P
-----
E
T
-
L
-
S
-
E
M
T
R
L
-
A
F
S
E
Y
R
------
Y
A
--------------
I
L
-----
G
D
A
A
E
D
-------
N
R
K
R
F
E
H
R
F
A
Q
I
-
L
S
A
------
Q
L
E
G
D
M
-
V
F
V
H
R
D
F
H
A
Q
N
L
L
W
L
-
P
-
E
R
EG--
L
A
R
V
G
V
I
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
V
S
-
L
L
----------------
Q
D
A
----------
R
R
D
V
-----------------
P
-
A
Q
V
----
E
A
Q
-----------------
M
-
I
D
H
Y
--
I
Q
A
T
G
--
V
D
E
S
--------------------------------------------------------------------------------------------
59
HHSearch
60.15
17%
-23
- C3 -
-
5UXA
-
?
A:
[3-257]
-------------------
K
D
I
K
Q
V
I
E
I
A
K
K
H
N
L
---------
F
L
---
K
E
E
T
I
Q
F
N
E
S
G
L
D
F
Q
A
V
F
-
A
Q
---
D
N
N
----
G
----
I
D
W
V
------
L
-
R
L
P
-
R
RED
V
-
M
-----
P
R
T
----------
K
V
E
K
Q
A
L
D
L
V
N
K
-
Y
-
A
I
S
F
Q
-
A
P
N
W
I
I
Y
T
---------------------
E
----
E
L
I
A
Y
K
K
L
D
-----
G
V
-
P
A
G
T
-----
I
-------------
D
HNIGNYIWEIDINNVP
E
-
L
F
H
K
S
L
G
-
R
V
L
A
E
-
L
H
S
I
P
S
N
-------------
K
A
A
A
L
D
L
-
V
V
-----
H
T
-
P
---
E
E
A
R
M
-
S
M
K
Q
R
M
------
D
A
V
-----
R
-----
A
-
K
F
-----
G
-
V
G
E
N
-------
L
W
N
R
W
Q
A
W
L
N
D
D
------
D
---
M
W
P
K
K
T
-
G
L
I
H
G
D
V
H
A
G
H
T
M
I
D
-
K
-
D
A
-----
N
V
T
G
L
I
D
W
T
E
A
K
V
T
D
V
S
H
D
F
I
F
-
N
Y
----------------
R
------------
A
--
F
-----------------
G
-
E
E
G
----
L
E
A
-----------------
L
-
I
L
A
Y
--
K
E
I
G
G
--
Y
-----------------------------------------------------------------------------------------------
58
HHSearch
59.94
17%
-20
- C3 -
-
5IWU
2
?
A:
[3-257]
-------------------
K
D
I
K
Q
V
I
E
I
A
K
K
H
N
L
---------
F
L
---
K
E
E
T
I
Q
F
N
E
S
G
L
D
F
Q
A
V
F
-
A
Q
---
D
N
N
----
G
----
I
D
W
V
------
L
-
R
L
P
-
R
RED
V
-
M
-----
P
R
T
----------
K
V
E
K
Q
A
L
D
L
V
N
K
-
Y
-
A
I
S
F
Q
-
A
P
N
W
I
I
Y
T
---------------------
E
----
E
L
I
A
Y
K
K
L
D
-----
G
V
-
P
A
G
T
-----
I
-------------
D
HNIGNYIWEIDINNVP
E
-
L
F
H
K
S
L
G
-
R
V
L
A
E
-
L
H
S
I
P
S
N
-------------
K
A
A
A
L
D
L
-
V
V
-----
H
T
-
P
---
E
E
A
R
M
-
S
M
K
Q
R
M
------
D
A
V
-----
R
-----
A
-
K
F
-----
G
-
V
G
E
N
-------
L
W
N
R
W
Q
A
W
L
N
D
D
------
D
---
M
W
P
K
K
T
-
G
L
I
H
G
D
V
H
A
G
H
T
M
I
D
-
K
-
D
A
-----
N
V
T
G
L
I
D
W
T
E
A
K
V
T
D
V
S
H
D
F
I
F
-
N
Y
----------------
R
------------
A
--
F
-----------------
G
-
E
E
G
----
L
E
A
-----------------
L
-
I
L
A
Y
--
K
E
I
G
G
--
Y
-----------------------------------------------------------------------------------------------
62
HHSearch
58.61
19%
-10
- C3 -
-
5IGI
3
?
A:
[5-257]
-----------------
T
T
A
D
T
S
Q
L
Y
A
L
A
A
R
-
H
G
---
L
----
K
L
H
-----
G
P
L
T
V
N
E
L
G
L
D
Y
R
I
V
I
-
A
T
---
V
D
D
----
G
----
R
R
W
V
------
L
-
R
I
PR
R
A
E
V
--
S
-----
A
K
V
----------
E
P
E
A
R
V
L
A
M
L
K
N
-
R
--
L
P
F
A
-
V
P
D
W
R
V
A
N
A
E
----------
L
V
------
A
Y
PMLE
D
S
T
A
-
V
I
Q
P
-----
G
S
-
S
T
P
D
WVVPQ
D
-------------
S
----------------
E
-
V
F
A
E
S
F
A
-
T
A
L
A
A
-
L
H
A
V
P
I
S
-------------
A
A
V
D
A
G
M
-
L
I
-----
R
T
-
P
---
T
Q
A
R
Q
-
K
V
A
D
D
V
------
D
R
V
-----
R
-----
R
-
E
F
-----
V
-
V
N
D
K
-------
R
L
H
R
W
Q
R
W
L
D
D
D
-
S
--------
S
W
P
D
F
S
-
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
-
N
-
T
E
-----
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
-
H
L
----------------
M
V
--------------
F
-----------------
G
-
E
E
G
----
L
A
K
-----------------
L
-
L
L
T
Y
--
E
A
A
G
G
--
R
-----------------------------------------------------------------------------------------------
56
HHSearch
53.58
15%
7
- C3 -
-
4R78
2
?
A:
[18-253]
-----------------
G
S
H
M
E
K
I
I
K
E
K
I
S
S
L
L
S
---
Q
E
-----
E
---
E
V
L
S
V
E
Q
L
-
G
G
M
T
N
Q
N
Y
L
-
A
K
---
T
T
N
---------
K
Q
Y
I
------
V
-
K
F
--
F
G----
K
GTEKL
I
N
R
----------
Q
D
E
K
Y
N
L
E
L
L
K
D
-
L
---
G
L
D
-
V
K
N
Y
L
F
D
I
--------------------
E
A
----
G
I
K
V
N
E
Y
I
E
-----
S
A
I
T
L
D
S
-----
T
-------------
S
I
---------------
K
-
T
K
F
D
K
I
A
-
P
I
L
Q
T
-
I
H
T
S
A
K
E
-------------
L
R
G
--
E
---------
F
A
-
P
-
F
-
E
E
I
-
K
-
K
Y
E
S
L
I
------
E
E
Q
--------------
I
-----
P
Y
A
----------
N
Y
E
S
V
R
N
A
V
F
S
L
-
E
K
R
-
L
A
---
D
L
G
V
D
R
-
K
S
C
H
I
D
L
V
P
E
N
F
I
E
S
-
P
-
Q
------
G
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
-
L
F
----------------
L
E
S
-----------
E
-
F
-----------------
T
-
S
Q
E
----
E
E
T
-----------------
F
-
L
S
H
Y
--
E
S
D
Q
T
--------------------------------------------------------------------------------------------------