@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B2UM73_AKKM8: (2019-01-26 )
MKELSRLVHRSFHIIPRQEDFRPLALGASGRTIVRIHFGGRTCIGIQWGNDRADNDSFIPAARHLHAHGVNVPEIYDYEPLGPGCGAALVEDLGDANLLAFRKEPWPSLRLRYIRAMEQLHLLHSCPFPEEFPLQPAFDEALYRWEQSYFAEHFLGSHLGLETASFLNHPALKEQAQFLAALPECPVHRDSQSQNVHIHAGKTWLIDFQGMRGGRPEYDLASLVYDGYARLEPEQADELLREWENISAHSIDHRIFRACALQRIMQMLGAYANIGHNQGKTWYLAQIPAGLGHLRKLLPGSTLAEPLAAMLA
Atome Classification :
(20 SA)
-------------------------...--------......10---......-----...---------20........30...-....----------.--------40.----------....-...50-.----.--.-..--....60.-......-.70........80---.-----.-----.....--..90-...-----..-...100..-.....------110........120.-......130-..--...-...----140-...-...-.-150.--.-------.----.-------.-..-160.-..---.--....170....---...-----180.--.------..-----.....190-----......--..-----200-----.-----.-..--------..-...210.......220..------------------.-.----...------------230--------------.----------------....------------....-240.....----------.--------------.250.--......260...-....270-----......--------..280.......290.......300.......310--------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------
M
K
E
--------
L
S
R
L
V
H
R
----SFHIIP-----RQE---------DFR
P
L
A
LGASG
R
T
I
V
-
R
I
HF----------G--------G
R
T
----------
C
I
G
I
-QWGN--D----R--A-DN--DS
F
I
P
A
A
-
R
H
L
H
AH-GVNVPEIYDYEP----L-----G-----PG
C
G
A
--
A
L
V
E
-DLG-----DA-N
L
L
A
FRKE-P
W
P
S
L
------
R
-
L
R
Y
I
R
A
M
E
Q
L
H
L
L
-HSCP
F
P
EE--FP--LQ
P
-
A
F
D
----
E
A
L
-
Y
R
W
-
E
Q
S
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Y
-
F
A
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H
--
F
-------
L
----
G
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-HL-GL-
E
-
T
A
---
S
--
F
LN
H
P
A
L
K
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Q
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---
Q
F
L
-----
A
--A--L------PE-----CPVHRDS------QS
Q
N
V
H
--
I
H-----A-------G-----
K
-
T
W
--------
L
I
-
D
FQGMRGGRPE
Y
D
L
A
S
L
V
------------------
Y
-D----GYA------------R----------------L----------------
E
P
E
Q
------------
A
D
E
L
-
L
R
E
W
ENIS----------A--------------H
S
I
D
H
--
R
I
F
R
A
C
A
L
Q
R
I
M
-
Q
M
L
G
A
Y
------
A
NIGHN--------QG
K
T
W
Y
L
A
QI
P
A
G
L
G
H
L
R
K
LLPG
S
T
L
A
E
P
L
A
A
MLA--------------------------------
22
Fugue
80.51
23%
-6
- C7 -
-
3CSV
11
?
A:
[4-333]
-----------------------S
R
E
D
E
--------
I
R
D
F
L
A
T
----
H
-------------------------
G
Y
A
D
W
N
R
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P
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-
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L
R
S
----------
P
--------
T
G
A
----------
K
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----
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--
G
-
G
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Q
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Q
Y
L
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L
-
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A
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----
A
-----
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--------
G
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--
L
L
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-
D
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-----
D
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N
N
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D
-
P
A
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------
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M
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R
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A
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L
L
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H
L
-
H
D
A
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T
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--------
L
A
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R
L
D
----
P
E
T
-
L
S
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L
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A
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F
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--
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-------
Y
----
A
-------
I
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A
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---
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--
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K
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L
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------
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H
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D
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------
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A
Q
N
L
L
--
W
L
PEREG
L
-------
A
-----
R
-
V
G
--------
V
I
-
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
V
S
L
L
------------------
Q
-
D
----
A
R
R
------------
D
----------------
V
-----------------
P
A
Q
------------
V
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A
Q
M
I
D
H
Y
I
Q
A
T
----------
G
--------------
V
D
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F
R
S
A
Y
A
V
I
A
V
Q
R
-
N
M
R
I
L
G
I
F
------
A
R
L
S
Q
R
--------
F
G
K
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H
Y
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W
A
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L
A
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P
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A
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I
L
N
A
L
PAPA
P
E
V
L
E
R
L
R
A-----------------
47
HHSearch
76.18
23%
7
- C7 -
-
3CSV
11
?
A:
[9-312]
------------------------------------
I
R
D
F
L
A
T
-----
H
G
--
Y
-----
A
D
W
---------
N
R
T
P
--------
R
Y
Q
R
L
R
S
P
----------
T
--------
G
A
K
----------
A
V
L
M
-
D
W
S
P
--
E
E---
G
--
G
-
D
T
--
Q
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A
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Y
L
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N
L
-
D
I
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A
P
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A
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H
-----------------
A
R
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L
--
L
L
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-
D
L
G
-----
D
A
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L
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T
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N
N
-
D
P
A
Q
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------
M
-
P
L
Y
R
A
A
V
D
L
L
I
H
L
-
H
D
A
Q
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P
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L
---
A
------
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L
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----
P
E
T
-
L
S
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-
M
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A
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--
R
------------
Y
-------
A
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L
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G
D
-
A
-
A
E
---
D
N
R
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R
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M
-----
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F
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H
R
D
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------
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N
L
L
--
W
L
-----
P
-------
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REGLA
R
-
V
G
--------
V
I
-
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
V
S
L
L
------------------
Q
-
D
----
A
R
R
------------
D
----------------
V
----------------
P
A
Q
V
------------
E
A
Q
M
-
I
D
H
Y
I
Q
A
T
GV--------
D
--------------
E
S
H
F
R
--
S
A
Y
A
V
I
A
V
Q
R
N
M
-
R
I
L
G
I
F
------
A
R
L
S
Q
R
--------
F
G
K
R
H
Y
I
E
F
V
P
R
V
W
A
H
F
E
R
G
L
A
-
H
P
A
L
A
S
A
-------------------------------------
26
Fugue
61.54
13%
24
- C7 -
-
3I1A
2
?
A:
[3-330]
--------------------KQPIQ
A
Q
Q
--------
L
I
E
L
L
K
V
----
H
Y
G
I
D
I
-----
H
T
A
---------
Q
F
I
Q
G
G
A
D
T
N
A
F
A
Y
Q
-
A
D
S
E
----------
S
--------
K
S
Y
----------
F
I
K
L
-
K
Y
G
Y
--
H
----
D
--
E
--------
I
N
L
S
-
I
I
R
L
L
H
-
D
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I
K
E
I
I
F
P
I
H
----
T
-----
L
-----
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A
-----
K
L
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Q
-
Q
L
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-----
H
F
-
K
I
I
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I
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H
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FT
Q
N
L
T
G
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K
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W
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L
R
Q
I
-
H
E
T
S
V
P
I
S
--
I
Q
--
Q
Q
L
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S
P
K
-
W
R
E
-
I
V
R
-
S
-
F
Y
N
Q
--
I
-------
E
----
F
-------
D
-
N
S
-
D
D
-
K
-
L
T
---
A
--
A
F
K
S
F
F
N
Q
N
S
A
---
A
I
H
-----
R
--
L
--
V
------
D
T
-----
S
E
K
L
S
K
K
IQPDLD
K
Y
V
L
C
H
SD
I
H
-----
A
-------
G
-----
N
-
V
L
VGNEE
S
I
Y
I
I
-
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
I
G
------------------
G
G
V
----
G
N
V
------------
W
----------------
N
----------------
K
P
H
E
------------
I
Q
Y
F
-
Y
E
G
Y
G
E
---------------------------
I
N
V
D
K
--
T
I
L
S
Y
Y
R
H
E
R
I
V
-
E
D
I
A
V
Y
------
G
Q
D
L
L
S
--------
R
N
Q
N
--
N
Q
S
R
L
E
S
F
K
Y
F
K
E
M
F
D
P
N
N
V
V
E
I
A
F
A
T
E
---------------------------------
39
SP3
57.18
13%
-8
- C7 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
--------G
M
K
E
L
L
S
T
MDLDTDANT
I
P
E
--------
L
K
E
R
A
H
M
----
L
C
A
R
F
L
-----
G
G
A
WKTVPLEH
L
R
I
S
R
I
K
G
G
M
S
N
-
M
L
F
-
L
C
R
L
----------
S
--------
E
V
Y
PPIRNEPN
K
V
L
L
R
V
-
Y
F
N
P
--
E
----
T
--
E
S
H
L
--
V
A
E
S
V
I
F
-
T
L
L
S
E
R
-
H
L
-
G
P
K
L
Y
--------------
G
-----
I
F
S
G
G
--
R
L
E
E
-
Y
I
P
-----
S
R
-
P
----
L
S
C
-
H
E
I
S
L
------
A
-
H
M
S
T
K
I
A
K
R
V
A
K
V
-
H
Q
L
E
V
P
----
I
W
--
K
E
P
-
D
Y
L
----
C
E
A
-
L
Q
R
-
W
L
K
-
Q
-
L
T
G
T
--
V
DAE
H
R
F
D
L
----
P
-------
E
-
E
C
-
G
V
S
S
-
V
N
---
C
--
L
D
L
A
R
E
L
E
F
L
R
---
A
H
I
-----
S
--
L
SK
S
------
P
V
-----
T
F
C
H
N
D
L
------
Q
E
G
N
I
L
--
L
P
-------------
K
-----
R
-
L
V
--------
L
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
------------------
I
-
E
----
W
T
I
------------
D
----------------
Y
DIDEAPF
Y
K
I
Q
TENFP
E
N
D
Q
------------
M
L
E
F
-
F
L
N
Y
L
R
E
Q
----------
G
--------------
N
T
R
E
N
--
E
--
L
Y
K
K
S
E
D
L
V
-
Q
E
T
L
P
F
------
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
V
G
F
--
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A
--------------------------------
34
Fugue
57.06
14%
-4
- C7 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
A
H
M
L
--------
C
A
R
F
L
G
G
----
A
W
K
T
V
P
-----
L
E
H
---------
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
-
L
C
R
L
S
EVYPPIRNE
P
--------
N
K
V
----------
L
L
R
V
-
Y
F
N
P
--
E
----
T
--
E
-
S
H
--
L
V
A
E
S
V
I
-
F
T
L
L
S
E
-
R
H
L
G
P
K
L
Y
G
I
F
S
----
G
-----
G
-------------
R
L
E
-
E
Y
I
-----
P
S
-
R
P
L
S
C
H
E
I
-
S
L
A
H
M
------
S
-
T
K
I
A
K
R
V
A
K
V
H
Q
L
-
E
V
P
I
W
K
E
P
--
D
Y
--
L
C
E
-
A
L
Q
----
R
W
L
-
K
Q
L
-
T
G
T
-
V
-
D
A
E
H
--
R
-------
F
----
D
-------
L
-
P
E
-
E
C
-
G
-
V
S
---
S
--
V
-
N
C
L
D
L
A
R
E
L
---
E
F
L
-----
R
--
A
--
H
I
S
L
SKS
P
V
-----
T
F
C
H
N
D
L
------
Q
E
G
N
I
L
--
L
P
-------------
K
-----
R
-
L
V
--------
L
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
------------------
I
-
E
----
W
T
I
------------
D
----------------
Y
----------------
D
I
D
E
------------
A
P
F
Y
-
K
I
Q
T
E
N
F
P
----------
E
----------------------------
N
D
Q
M
L
-
E
F
F
L
N
Y
------
L
R
E
Q
G
N
--------
T
R
E
N
E
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
ELSPVGFG
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA
28
Fugue
54.93
14%
18
- C7 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
---------------------TDIT
E
D
E
--------
L
R
N
F
L
T
Q
Y
DVG
S
L
T
S
Y
K
-----
G
I
A
---------
E
N
S
N
F
L
L
H
T
T
K
D
P
L
I
-
L
T
L
Y
-------------------------------------------
E
----
K
--
K
-
N
D
--
L
P
F
F
L
G
L
M
Q
H
L
A
A
K
-
G
L
S
C
P
L
-----
P
----
L
-----
P
-----
R
K
D
G
E
--
L
L
G
E
L
S
G
R
-----
P
A
-
A
L
I
S
F
L
E
G
M
W
L
R
K
P
------
E
-
A
K
H
C
R
E
V
G
K
A
L
A
A
M
H
L
A
S
E
G
F
E
--
I
K
--
R
P
N
-
A
L
S
----
V
D
G
-
W
K
V
-
L
W
D
-
K
-
S
E
E
R
--
A
-------
D
----
E
-------
V
-
E
K
-
G
L
-
R
-
E
E
---
I
--
R
P
E
I
D
Y
L
A
A
H
W
---
P
-------
K
--
D
--
L
------
P
A
-----
G
V
I
H
A
D
L
------
F
Q
D
N
V
F
--
F
L
G----
D
-------
E
-----
L
-
S
G
--------
L
I
-
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
------------------
N
-
A
WCFE
K
D
G
------------
A
----------------
Y
----------------
N
V
T
K
------------
G
K
A
L
-
L
E
G
Y
Q
S
V
R
----------
P
L
S
------------
E
A
E
L
E
--
A
L
P
L
L
S
R
G
S
A
L
R
-
F
F
L
T
R
L
------
Y
D
W
L
T
T
--------
P
A
G
A
L
V
V
K
K
D
P
L
E
Y
L
R
K
L
R
F
H
R
T
I
A
N
V
A
E
Y
G
L
A
----------------------------------
23
Fugue
52.64
14%
11
- C7 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
----------------SAFT
F
Q
T
L
H
P
D
T
--------
I
M
D
A
L
F
E
------
H
G
I
R
-----
V
D
S
---------
G
L
T
P
L
N
S
Y
E
N
R
V
Y
Q
F
-
Q
D
E
D
----------
R
--------
R
R
F
----------
V
V
K
F
-
Y
R
P
E
RW
T
----
A
--
D
-
Q
I
--
L
E
E
H
Q
F
A
-
L
Q
L
V
N
D
-
E
V
P
V
A
A
P
V
A
F
N
G
QT
L
L
N
-----
H
-----
Q
G
F
Y
F
--
A
V
F
P
-
S
V
G
-----
G
--------
R
Q
-
F
E
A
D
N
------
I
-
D
Q
M
E
A
V
G
R
Y
L
G
R
M
-
H
Q
T
G
R
K
Q
L
--
F
I
--
H
R
P
-
T
I
G
----
L
N
E
-
Y
L
I
-
E
P
R
-
K
-
L
F
E
D
AT
L
-------
I
----
P
-------
S
-
G
L
-
K
A
-
A
-
F
L
---
K
--
A
T
D
E
L
I
A
A
V
T
A
---
H
W
R
-----
E
--
D
--
F
------
T
V
-----
L
R
L
H
G
D
C
------
H
A
G
N
I
L
--
W
R
-------------
D
-----
G
-
P
M
--------
F
V
-
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
-
M
L
------------------
L
-
N
----
G
D
K
------------
A
----------------
E
----------------
Q
R
M
Q
------------
L
E
T
I
-
I
E
A
Y
E
--
E
----------
F
--------------
S
E
F
D
T
--
A
E
I
G
L
I
E
P
L
R
A
M
-
R
L
V
Y
Y
L
------
A
W
L
M
R
R
--------
W
A
D
P
A
F
P
K
N
F
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
E
PPLQLTPMY-----------------------
50
HHSearch
52.46
18%
-22
- C7 -
-
3DXQ
-
?
B:
[21-254]
----------------------------------------------------------------------
G
P
L
E
R
L
G
G
L
T
N
L
V
F
R
-
A
-----------------------
G
D
----------
L
C
L
R
-
I
P
--------------
N
R
--
A
N
E
A
V
A
A
-
R
E
A
A
K
A
-
G
V
S
-
P
E
V
L
H
V
D
P
-----------------
A
T
G
V
--
M
V
T
R
-
Y
I
A
-----
G
A
Q
T
M
S
P
E
K
F
K
-
T
---
R
------
P
-
G
S
P
A
R
A
G
E
A
F
R
K
L
-
H
G
S
G
A
V
F
P
--
F
R
---
F
--
E
L
F
-----
A
------
M
I
D
-
D
-
Y
L
K
V
--
L
-------
S
----
T
-------
K
-
N
V
-
T
L
-
P
-
A
G
---
Y
--
H
D
V
V
R
E
A
G
G
V
R
---
S
A
L
-----
A
--
A
H
P
L
------
P
L
-----
A
A
C
H
C
D
P
------
L
C
E
N
F
L
--
D
T
-----
G
-------
E
-----
R
-
M
W
--------
I
V
-
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
D
L
S
------------------
V
-
E
----
G
--------------
K
----------------
F
----------------
N
A
N
Q
------------
D
E
E
L
-
M
R
A
Y
F
G
G
E
----------
A
--------------
R
P
A
E
R
--
G
R
V
V
I
Y
K
A
M
C
D
L
-
L
W
T
------------------------------------------------------------------------------------------
29
Fugue
51.97
12%
-8
- C7 -
-
3HAM
3
?
A:
[1-299]
-------------------------
M
V
N
--------
L
D
A
E
I
Y
E
----
H
L
N
K
Q
I
-----
K
I
N
---------
E
L
R
Y
L
S
S
G
---
D
D
S
D
-
T
F
L
C
----------
N
--------
E
Q
------------
Y
V
V
-
K
V
P
K
--
R
----
D
--
S
-
V
R
--
I
S
Q
K
R
E
F
-
E
L
Y
R
F
L
-
E
N
C
K
L
S
Y
Q
I
P
A
V
----
V
-----
Y
-----
Q
S
D
R
F
--
N
I
M
K
-
Y
I
K
G
E
R
I
T
Y
E
-
Q
Y
H
K
L
S
E
K
-
E
K
D
A
L
------
A
-
Y
D
E
A
T
F
L
K
E
L
H
S
I
-
E
I
D
C
S
V
S
L
--
F
S
DA
L
V
N
-
K
K
D
----
K
F
L
-
Q
D
K
-
K
L
L
-
I
-
S
I
L
E
--
K
-------
E
----
Q
-------
L
-
L
T
-
D
E
-
M
-
L
E
---
H
--
I
E
T
I
Y
E
N
I
L
N
N
---
A
V
L
-----
F
--
K
--
Y
------
T
P
-----
C
L
V
H
N
D
F
------
S
A
N
N
M
I
--
F
R
-----
N
-------
N
-----
R
L
F
G
--------
V
I
-
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
L
---------------------------
L
D
------------
C
----------------
S
----------------
T
D
D
F
------------
G
K
E
F
-
G
R
K
V
L
K
Y
Y
----------
Q
--------------
H
K
A
P
E
--
V
A
E
R
K
A
E
L
N
D
V
Y
-
W
S
I
D
Q
I
------
I
Y
G
Y
E
R
--------
K
D
--------
R
E
M
L
I
K
G
V
S
E
L
L
-
Q
T
Q
A
E
M
F
I
F
-----------------------------------
27
Fugue
51.36
12%
7
- C7 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
-------------KTPL
Y
E
T
L
N
E
S
S
A
V
A
--------
L
A
V
K
L
G
L
----
T
L
T
C
Q
E
-----
I
G
D
---------
G
N
L
N
Y
V
F
H
I
Y
D
R
A
L
I
-
I
K
Q
A
----------
V
--------
P
--------------
Y
W
-
P
L
T
I
--
D
----
R
--
A
-
R
I
--
E
S
S
A
L
I
R
-
Q
G
E
H
V
P
-
H
L
-
V
P
R
V
F
Y
S
D
T
----
E
-----
M
-----
A
V
T
V
M
--
E
D
L
S
-
H
L
K
-----
I
A
-
R
K
G
L
I
E
G
E
-
N
Y
P
H
L
------
S
-
Q
H
I
G
E
F
L
G
K
T
L
F
Y
-
S
S
D
Y
A
L
E
P
--
K
V
--
K
K
Q
-
L
V
K
Q
F
TN
P
E
L
-
C
D
I
-
T
E
R
-
L
V
F
T
D
P
--
F
-------
F
----
D
HDT
N
D
F
E
E
-
E
L
-
R
P
-
F
-
V
E
---
K
--
L
W
N
N
D
S
V
K
I
E
A
---
A
K
L
-----
K
--
K
--
S
------
F
L
TSAE-
T
L
I
H
G
D
L
------
H
T
G
S
I
F
--
A
S
-----
E
-------
H
-----
E
-
T
K
--------
V
I
-
D
P
E
F
A
F
Y
G
P
I
G
F
D
V
G
Q
F
I
A
N
L
F
L
N
A
L
S
R
DGADR
E
P
L
Y
-
E
----
H
V
N
------------
Q
----------------
V
----------------
W
E
T
F
------------
E
E
T
F
-
S
E
A
W
Q
K
D
S
LDVYANIDG
Y
L
--------------
T
D
T
L
S
--
H
I
F
E
E
A
I
G
F
A
G
C
-
E
L
I
R
R
T
IGLAHV
A
D
L
D
T
I
--------
V
P
F
D
K
R
I
G
R
K
R
L
A
L
E
T
G
T
A
F
I
E
K
R
S
E
F
K
T
I
T
D
V
I
E
L
F
K
L
L
V
K-------------------------
30
Fugue
51.06
13%
-9
- C7 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
----------------T
L
P
A
V
I
S
R
W
L
S
S
V
LPGGAA
P
E
V
T
V
E
S
G
----
V
D
S
T
G
M
-----
S
S
E
---------
T
I
I
L
T
A
R
W
Q
Q
D
G
R
S
I
-
Q
Q
K
L
----------
V
--------
A
R
V
----------
A
P
A
A
-
E
D
V
P
--
V
----
F
--
P
-
T
Y
R
L
D
H
Q
F
E
V
I
-
R
L
V
G
E
L
T
D
V
P
V
P
R
V
R
W
I
E
T
----
T
-----
G
-----
D
V
L
G
T
P
F
F
L
M
D
-
Y
V
E
G
V
V
PP
D
V
-
M
P
Y
T
F
G
D
N
-
W
F
A
D
A
P
A
E
R
Q
-
R
-
Q
L
Q
D
A
T
V
A
A
L
A
T
L
-
H
S
I
P
N
A
Q
N
T
F
S
F
--
L
T
D
-
T
T
L
----
H
R
H
-
F
N
W
-
V
R
S
-
W
-
Y
D
F
A
--
V
-------
E
----
G
-------
I
-
G
R
-
S
P
-
L
-
L
E
---
R
--
T
F
E
W
L
Q
S
H
W
P
D
---
D
A
A
-----
A
--
R
---------
E
P
-----
V
L
L
W
G
D
A
------
R
V
G
N
V
L
--
Y
R
-----
D
-------
F
-----
Q
-
P
V
--------
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
W
M
I
------------------
F
-
A
----
H
R
V
------------
F
----------------
Q
----------------
E
L
A
G
L
A
TLPGLPEVMR
E
D
D
V
-
R
A
T
Y
Q
A
L
T
----------
G
--------------
V
E
L
G
D
L-
H
W
F
Y
V
Y
S
G
V
M
W
A
-
C
V
F
M
R
T
------
G
A
R
R
V
H
--------
F
G
E
I
-
E
K
P
D
D
V
E
S
L
F
Y
H
A
G
L
M
K
H
L
L
G
E
E
H
--------------------------------------
49
HHSearch
50.12
18%
-19
- C- -
-
3DXQ
-
?
A:
[21-254]
----------------------------------------------------------------------
G
P
L
E
R
L
G
G
L
T
N
L
V
F
R
-
A
-----------------------
G
D
----------
L
C
L
R
-
I
P
G
K
-------
Y
--
I
-
N
R
--
A
N
E
A
V
A
A
-
R
E
A
A
K
A
-
G
V
S
-
P
E
V
L
H
V
D
P
-----------------
A
T
G
V
--
M
V
T
R
-
Y
I
A
-----
G
A
Q
T
M
S
P
E
K
F
K
-
T
---
R
------
P
-
G
S
P
A
R
A
G
E
A
F
R
K
L
-
H
G
S
G
A
V
F
P
--
F
R
---
F
--
E
L
F
-----
A
------
M
I
D
-
D
-
Y
L
K
V
--
L
-------
S
--------------
N
V
-
T
L
-
P
-
A
G
---
Y
--
H
D
V
V
R
E
A
G
G
V
R
---
S
A
L
-----
A
--
A
H
P
L
------
P
L
-----
A
A
C
H
C
D
P
------
L
C
E
N
F
L
--
D
T
-----
G
-------
E
-----
R
-
M
W
--------
I
V
-
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
D
L
S
------------------
V
-
E
----
G
--------------
K
----------------
F
----------------
N
A
N
Q
------------
D
E
E
L
-
M
R
A
Y
F
G
G
E
----------
A
--------------
R
P
A
E
R
--
G
R
V
V
I
Y
K
A
M
C
D
L
-
L
W
T
------------------------------------------------------------------------------------------
59
HHSearch
48.49
17%
-31
- C7 -
-
2PPQ
-
KHSE_AGRFC
A:
[11-255]
---------------------------
E
--------
L
R
N
F
L
T
-----
Q
Y
D
V
G
------
S
L
T
---------
S
Y
K
G
I
A
E
---
N
S
N
F
L
-
L
H
T
T
-------------------
K
D
P
----------
L
I
L
T
-
L
Y
E
K
-------
K
--
N
-
D
L
--
P
F
F
L
G
L
M
-
Q
H
L
A
A
K
-
G
L
S
C
P
L
P
L
P
R
K
D
----
G
-----
E
L
L
G
E
L
S
G
R
P
A
--
A
L
I
S
-
F
L
E
-----
G
M
-
W
L
R
K
P
--------
E
------
A
-
K
H
C
R
E
V
G
K
A
L
A
A
M
-
H
L
A
S
E
G
F
E
--
I
K
--
R
P
N
-
A
L
S
----
V
D
G
-
W
K
V
-
L
W
D
-
K
-
S
E
E
R
--
A
------------
D
-------
E
-
V
E
-
K
--
G
-
L
----
R
--
E
E
I
R
P
E
I
D
Y
L
A
---
A
H
W
-----
P
K-
D
--
L
------
P
A
-----
G
V
I
H
A
D
L
------
F
Q
D
N
V
F
--
F
L
-----
G
D------
E
-----
L
-
S
G
--------
L
I
-
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
------------------
N
-
A
----
W
C
F
EKDG--------
A
----------------
Y
----------------
N
V
T
K
------------
G
K
A
L
-
L
E
G
Y
Q
S
V
R
------------------------------------------------------------------------------------------------------------------------------------------
37
SP3
47.13
11%
-19
- C7 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
---------------------------------------
G
S
P
A
----
A
W
V
E
R
L
-----
F
G
Y
---------
D
W
A
Q
Q
T
I
G
C
S
D
A
A
V
F
-
R
L
S
A
----------
Q
--------
G
R
P
----------
V
L
F
V
-
K
T
D
L
SG
A
----
L
--
N
-
E
L
--
Q
D
E
A
A
R
L
-
S
W
L
A
T
T
-
G
V
P
C
A
A
V
L
D
V
-
V
----
T
-----
E
-----
A
G
R
D
W
--
L
L
L
G
-
E
V
P
-----
G
Q
-
D
----
L
L
S
-
S
H
L
A
P
------
A
-
E
K
V
S
I
M
A
D
A
M
R
R
L
-
H
T
L
D
P
A
T
-------
C
P
F
-
D
H
Q
----
A
K
H
-
R
I
E
-
R
A
R
-
T
-
R
M
E
----------------
A
-------
G
-
L
V
-
D
Q
-
D
D
L
D
---
E
--
E
H
Q
G
L
A
P
A
E
L
F
---
A
R
L
-----
K
--
A
--
R
------
M
P
DGEDL
V
V
T
H
G
D
A
------
C
L
P
N
I
M
--
V
E
-----
N
-------
G
-----
R
F
S
G
--------
F
I
-
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
T
------------------
R
-
D
----
I
A
E
------------
E
----------------
L
----------------
G
G
E
W
------------
A
D
R
F
-
L
V
L
Y
------------------------------
G
I
A
A
--
P
D
S
Q
R
I
A
F
Y
R
L
L
-
D
E
F
--
F
---------------------------------------------------------------------------------------
55
HHSearch
46.45
12%
-22
- C7 -
-
5FTG
11
CHKA_HUMAN
A:
[11-344]
---------------------------
R
--------
A
Y
L
W
C
K
E
----
F
L
P
G
A
W
RGLRE
D
E
F
---------
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
-
C
S
L
P
----------
D
TTATLGDE
P
R
K
----------
V
L
L
R
-
L
Y
G
-----------
E
-
A
M
--
V
L
E
S
V
M
F
-
A
I
L
A
E
R
-
S
L
G
-
P
K
L
Y
G
I
F
P
-------------------
Q
G
--
R
L
E
Q
-
F
I
P
-----
S
R
-
R
L
D
T
E
E
L
S
-----
L
------
P
-
D
I
S
A
E
I
A
E
K
M
A
T
F
-
H
G
M
K
M
P
F
N
--
K
E
---
P
K
-
W
L
F
-----
G
T
-
M
E
K
-
Y
L
K
-
E
-
V
L
R
I
--
K
-------
F
----
T
-------
E
-
E
S
R
I
K
-
K
-
L
H
K
L
L
S
--
Y
N
L
P
L
E
L
E
N
L
R
---
S
L
L
-----
E
S
T
P
--
S
------
P
V
-----
V
F
C
H
N
D
C
------
Q
E
G
N
I
L
--
L
L
-----
E
GRENSEK
Q
-----
K
-
L
M
--------
L
I
-
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
------------------
C
-
E
----
W
M
Y
------------
D
YSYEKYPF
F
R
A
N
IRKY
P
----------------
T
K
K
Q
------------
Q
L
H
F
-
I
S
S
Y
L
P
A
F
----------
Q
NDFENLS
T
E
E
K
S
I
I
K
E
E
M
L
--
L
E
V
N
R
F
A
L
A
S
H
F
-
L
W
G
L
W
----------------------------------------------------------------------------------------
56
HHSearch
46.12
12%
-13
- C7 -
-
5FUT
10
CHKA_HUMAN
A:
[11-344]
---------------------------
R
--------
A
Y
L
W
C
K
E
----
F
L
P
G
A
W
RGLRE
D
E
F
---------
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
-
C
S
L
P
----------
D
TTATLGDE
P
R
K
----------
V
L
L
R
-
L
Y
G
---------G
A
E
-
A
M
--
V
L
E
S
V
M
F
-
A
I
L
A
E
R
-
S
L
G
-
P
K
L
Y
G
I
F
P
-------------------
Q
G
--
R
L
E
Q
-
F
I
P
-----
S
R
-
R
L
D
T
E
E
L
S
-----
L
------
P
-
D
I
S
A
E
I
A
E
K
M
A
T
F
-
H
G
M
K
M
P
F
N
--
K
E
---
P
K
-
W
L
F
-----
G
T
-
M
E
K
-
Y
L
K
-
E
-
V
L
R
I
--
K
-------
F
----
T
-------
E
-
E
S
R
I
K
-
K
-
L
H
K
L
L
S
--
Y
N
L
P
L
E
L
E
N
L
R
---
S
L
L
-----
E
S
T
P
--
S
------
P
V
-----
V
F
C
H
N
D
C
------
Q
E
G
N
I
L
--
L
L
-----
E
GRENSEK
Q
-----
K
-
L
M
--------
L
I
-
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
------------------
C
-
E
----
W
M
Y
------------
D
YSYEKYPF
F
R
A
N
IRKY
P
----------------
T
K
K
Q
------------
Q
L
H
F
-
I
S
S
Y
L
P
A
F
----------
Q
NDFENLS
T
E
E
K
S
I
I
K
E
E
M
L
--
L
E
V
N
R
F
A
L
A
S
H
F
-
L
W
G
L
W
----------------------------------------------------------------------------------------
52
HHSearch
45.07
13%
-16
- C7 -
-
1ZYL
-
SRKA_ECOLI
A:
[15-275]
---------------------------
T
--------
I
M
D
A
L
F
E
-----
H
G
I
R
------
V
D
S
---------
G
L
T
P
L
-
N
S
Y
E
N
R
V
Y
Q
-
F
Q
D
E
----------
D
--------
R
R
R
----------
F
V
V
K
-
F
Y
R
P
--
E
RWT-
A
--
D
-
Q
I
--
L
E
E
H
Q
F
A
-
L
Q
L
V
N
D
-
E
V
P
V
A
A
P
V
A
F
N
G
----
Q
T
L
L
N
-
H
-----
Q
G
F
Y
F
--
A
V
F
P
-
S
V
G
-----
G
R
-
Q
F
E
A
D
--------
N
------
I
-
D
Q
M
E
A
V
G
R
Y
L
G
R
M
-
H
Q
T
G
R
K
Q
L
--
F
I
--
H
R
P
-
T
I
G
----
L
N
E
-----
Y
L
I
-
E
-
P
R
K
L
--
F
-------
E
----
D
-------
A
T
L
I
-
P
S
-
G
-
L
----
K
--
A
A
F
L
K
A
T
D
E
L
I
---
A
A
V
T
A
H
WR
E
--
D
--
F
------
T
V
-----
L
R
L
H
G
D
C
------
H
A
G
N
I
L
--
W
R
-----
D
-------------
G
-
P
M
--------
F
V
-
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
L
L
------------------
N
-
G
----
D
K
-------------
A
----------------
E
----------------
Q
R
M
Q
------------
L
E
T
I
-
I
E
A
Y
E
E
F
S
----------
E
F-------------
D
T
A
E
I
--
G
L
I
E
P
L
R
A
M
R
L
V
----------------------------------------------------------------------------------------------
60
HHSearch
41.96
12%
-22
- C7 -
-
4OCV
2
?
A:
[29-298]
--------------------------------------
F
D
V
A
S
----
H
F
A
L
E
G
-----
T
V
D
---------
S
I
E
P
Y
G
D
G
H
I
N
T
T
Y
L
-
V
T
T
D
-------------------
G
P
R
----------
Y
I
L
Q
-
R
M
N
T
--
G
IFPD
T
--
V
-
N
L
M
-
R
N
V
E
L
V
T
-
S
T
L
K
A
Q
-
G
K
E
T
L
D
I
V
R
T
T
S
----
G
DTWAE
I
-----
D
G
G
A
W
--
R
V
Y
K
-
F
I
E
-----
H
T
-
M
S
Y
N
L
V
P
------
N
------
P
-
D
V
F
R
E
A
G
R
A
F
G
D
F
-
Q
N
F
L
S
G
F
D
--
A
N
--
Q
L
T
E
T
I
A
----
H
F
H
D
T
P
H
-
R
F
E
-
D
-
F
K
K
A
--
L
-------
A
A
DEL
G
-------
R
-
A
A
-
G
C
-
G
-
P
E
---
I
--
E
F
Y
L
S
H
A
D
Q
Y
A
V
V
M
D
G
L
-----
R
D
G
S
--
I
------
P
L
-----
R
V
T
H
N
D
T
------
K
L
N
N
I
L
--
M
D
-----
A
TTG----
K
-----
A
-
R
A
--------
I
I
-
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
S
I
------------------
R
-
F
----
G
A
S
TALEDERDLDK
V
H
----------------
F
----------------
S
T
E
L
------------
F
R
A
Y
-
T
E
G
F
V
G
--------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
41.38
14%
-31
- C7 -
-
5IGH
-
?
A:
[11-255]
---------------------------
Q
--------
L
Y
A
L
A
A
R
-----
H
G
L
K
------
L
H
G
---------
P
L
T
V
N
E
L
G
L
D
Y
R
I
V
I
-
A
T
V
D
----------
D
--------
G
R
R
----------
W
V
L
R
-
I
P
R
R
--
A
E
V
--
S
--
A
-
K
V
--
E
P
E
A
R
V
L
-
A
M
L
K
N
R
L
P
F
A
V
P
D
W
R
V
A
N
A
----
E
-----
L
V
A
Y
P
-
M
L
E
D
S
--
T
A
M
V
-
I
Q
P
-----
G
S
-
S
T
P
D
W
V
V
P
---
Q
D
S
------
E
-
V
F
A
E
S
F
A
T
A
L
A
A
L
-
H
A
V
P
I
S
A
A
--
V
D
A
-
G
M
L
-
I
R
T
----
P
T
Q
-
A
R
Q
-
K
V
A
-
D
-
D
V
D
R
--
V
-------
R
----
R
-------
E
-----
F
-
V
-
V
N
---
D
--
K
R
-
L
H
R
W
Q
R
W
L
---
D
D
D
S----
S
W-
P
--
D
------
F
S
-----
V
V
V
H
G
D
L
------
Y
V
G
H
V
L
--
I
D
-----
N
TE-----
R
-----
V
-
S
G
--------
M
I
-
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
L
------------------
M
-
V
------------------------------------
F
----------------
G
E
E
G
------------
L
A
K
L
-
L
L
T
Y
E
A
A
G
------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
40.69
15%
30
- C7 -
-
4R78
2
?
A:
[38-252]
----------------------------------------------------------
E
V
L
---------
S
V
E
Q
L
-
G
G
M
T
N
Q
N
Y
L
-
A
K
T
T
-------------------
N
K
Q
----------
Y
I
V
K
-
F
F
G
K
--
G
TEK-
L
--
I
-
N
R
--
Q
D
E
K
Y
N
L
-
E
L
L
K
D
L
-
G
L
D
V
K
N
Y
L
F
D
I
------------------
E
A
G
I
--
K
V
N
E
-
Y
I
E
-----
S
A
I
T
L
D
S
T
S
-------
I
------
K
-
T
K
F
D
K
I
A
P
I
L
Q
T
I
-
H
T
S
A
K
E
L
R
--
G
E
---
F
A
-
P
F
E
------------
E
I
K
-
K
-
Y
E
S
L
--
I
-------
E
----
E
-------
Q
--
I
-
P
Y
-
A
-
N
----
Y
--
E
S
V
R
N
A
V
F
S
L
E
---
K
R
L
-----
A
--
D
L
G
V
------
D
R
-----
K
S
C
H
I
D
L
------
V
P
E
N
F
I
--
E
S
-----
P
Q------
G
-----
R
-
L
Y
--------
L
I
-
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
------------------
L
-
E
----
S
--------------
E
----------------
F
----------------
T
S
Q
E
------------
E
E
T
F
-
L
S
H
Y
E
S
D
Q
------------------------------------------------------------------------------------------------------------------------------------------