@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : C9Z3E0_STRSW: (2019-01-27 )
MAETHTAIVFFAGDRAYKVKKAVDLGFVDYTDRQARRAACVREVALNRRFAPDVYLGVGEVVAPDAEVSEPLVVMRRMPAGRRLSALVRAGADVDEVLRAVARRLAAWHATAPRGRDVDEQGTRDALASRWEASFEQVRATTEGGSGFDGVPEVQRLVRRYLAGREALFDSRIEQRRVVDGHGDLLAEDIFCLDDGPRVLDCLEFDDHLRYVDGLDDAAFLAMDLEQLGAPAAAARFLARYGEYSGDPAPPSLWHHYVAYRAFVRAKVSLIQAEQGAPGVRSAARRLVSTTLRHLRTSAVGLTLVGGLPGSGKSTLSGALADRLGVTLLSSDRLRKELAGIPPESPAPAAYEEGLYTPEWTARTYDILLDRAAALLSRGESVVLDATWSAAELRAAAGRVAERTCADLVALHCQVPDEVAAARLSTRSPGPSDADLGVADALAAREPPWPDAVVVDTSGPLESAVSRALAAVRPWGTDQAPVFRRPSAEPDQDRGAGSSLP
Atome Classification :
(22 SA)
-----------------------------------------------------------------------------------------------...-..----....10........20...-.....30.....------...40-----------------........50..------....-----..60........70.......-.80........90...--------------.....100...-....110.......120.......130--------------.......140------.........150...----------....160....-.--....170-----........180.......190----....--....200.......210.......220.......230----------------------.........240.......250.......260..----------------.....---270.......--280.......290.......300-.........310.......320..------.------.--..--.330-........--340.......350.--......360.......370....-...-380.......390.......400.......410.......420-----..-----.....-.430------.-.---..------...-.-440.....--.---.----450------.--.......-460.......470.......480.......490.......500--------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------MAE-
T
H
----
T
A
I
V
F
F
AGD
R
A
Y
K
V
K
K
A
V
D-LGFVDY
T
D
R
Q
A
R
------
R
A
A
C
V
-----------------
R
E
V
A
LNRRFAPD------
V
Y
L
G-----VGEVVAPDAEVS
E
P
L
V
V
M
RRM-PA
G
R
R
L
S
A
L
V
RAGA
D
V
--------------
D
E
V
L
R
A
V
A
R
R
L
-
A
A
W
HATAPRGRDVDEQG
T
R
D
A
L
A
S
R
W
E
--------------
A
S
F
E
Q
V
R
A--------TTEGGSGFDG
V
P
E
V
Q
----------
R
L
V
R
R
--
Y
LAG-
R
--
E
A
L
F
D
S
------
R
I
E
Q
R
R
VVDGHG
D
L
L
A
E
D
I
F
-----CLDD--GP
R
V
L
D
CLEFDDH
L
R
Y
VDGLD
D
A
A
F
L
A
M
D
L
E
Q
LGA------------------------
P
A
A
A
A
R
F
L
A
R
YGEYSGDPA
P
P
S
L
W
H
H
Y
V
A
Y
R
A
F
V
----------------
R
A
K
V
S
---
L
I
QAEQGAP
G
--
V
R
S
A
A
R
R
L
V
S
T
T
L
R
H
L
R
TSAV---
G
L
T
L
VGGLPGSG
K
S
T
L
S
G
A
L
A
D
RL------
G
------
V
--
T
L--L
S
S
--
D
R
L
R
K
E
L
A--GIPPESPAP
A
A
Y
EE--GLYTPEWTA
R
T
Y
D
I
L
L
D
R
A
A
A
L
L
-SRG-
E
S
V
V
L
DATW
S
A
A
E
L
R
A
A
A
G
R
V
A
E
R
T
C
A
D
L
V
A
L
HCQV
P
D
E
V
A
A
------
A
R
-----LSTRS-PGP-------S-D---AD------L
G
V
-
A
-
D
A
L
AAREP--P---W----P
D
-------
A
--
V
V
V
DTSG-
P
L
E
S
A
V
S
R
A
L
A
A
VRPWGTDQAPVFRRPSAEPDQDRGAGSSLP---------------
114
Fugue
70.55
16%
24
- C5 -
-
1I2D
2
MET3_PENCH
A:
[2-573]
-----------------------------------------------------------------------------------------------
A
N
A
-
P
H
GGVL
K
D
L
L
A
R
D
A
P
R
Q
A
E
L
A
A
E
A
E
S
L
P
A
V
T
L
T
E
R
Q
L
C
------
D
L
E
L
I
M
N
GGFSPLEGFMN
Q
A
D
Y
D
R
V
C
E
D
N
R
L
A
D
G
NVFS
M
P
I
T
L
D
-----
A
S
Q
E
V
I
D
E
K
K
L
Q
A
G
S
R
I
T
L
R
D
-
F
R
D
D
R
N
L
A
I
L
T
I
D
D
I
Y
--------------
R
P
D
K
T
K
E
A
K
L
V
-
F
G
G
D
P
E
H
P
A
I
V
Y
L
N
N
T
V
K
E
F
Y
I
G
G
K
I
E
A
VNKLNHYDYVALR
Y
T
P
A
E
L
R
V
--------
H
F
D
K
L
-
G
W
S
R
V
V
A
F
Q
T
RNPMH
R
A
H
R
E
L
T
V
R
--
A
A
R
S
-
R
Q
A
N
V
L
I
H
P
------
V
V
G
L
T
K
P
G
D
I
D
H
F
T
R
V
R
A
Y
Q
-----
A
L
L
P
RY
P
N
G
M
A
V
L
G
L
L
G
L
A
M
R
M
G
-
G
P
R
E
A
I
W
H
A
I
I
R
K
N
H
G
A
T
H
F
I
V
G
R
DHAGPGSNSKGEDFYGP
Y
D
A
Q
H
A
V
E
K
Y
K
D
E
L
G
I
E
V
V
E
F
Q
M
V
T
Y
L
P
D
T
D
E
Y
R
P
VDQVPAG
V
K
T
L
N
I
S
G
T
E
L
R
R
---
R
L
R
S
G
A
H
I
P
E
WF
S
Y
P
E
V
V
K
I
L
R
E
S
N
P
P
R
A
T
Q
G
F
---
T
I
F
L
T
G
-
Y
M
N
S
G
K
D
A
I
A
R
A
L
Q
V
T
L
------
N
Q
Q
GG
R
S
V
--
S
L
--
L
L
G
--
D
T
V
R
H
E
L
S
--
S
E
L
G
--------------
F
T
R
E
D
R
H
T
N
I
Q
R
I
A
F
V
A
T
E
L
T
-
R
A
G
-
A
A
V
I
A
A
P
I
A
P
Y
E
E
S
R
K
F
A
R
D
A
V
S
Q
A
-
G
S
F
F
L
V
H
V
A
T
P
L
E
H
C
E
------
Q
S
DKRG
I
Y
A
A
A
R
-
R
G
E
-------
I
-
K
---
G
F
------
T
G
V
-
D
-
D
P
Y
E
--
T
P
--
E
---
K
----
A
D
-------
L
--
V
V
D
F
S
K
Q
-
S
V
R
S
I
V
H
E
I
I
L
V
L
E
S
Q
G
F
L
E
R
Q
-----------------------------------
116
Fugue
63.38
18%
-29
- C2 -
-
5F4H
5
?
A:
[1-437]
----------------------------------------------------------------------------------------------------
M
----
N
D
L
M
L
---
D
-----
K
S
A
L
L
-
F
G
V
S
K
Y
L
E
K
G
I
I
------
T
G
N
V
L
-----------------
I
H
K
S
L
L
A
E
L
E
R
E
------
S
N
D
G
-----
L
V
S
A
E
I
A
L
D
E
V
K
K
L
K
D
I
T
E
R
I
-
L
V
N
F
E
I
V
G
D
D
S
K
K
G
E
A
--------------
N
E
L
S
R
E
Y
C
L
E
K
-
G
C
I
I
V
T
A
D
--------
E
T
Q
K
K
I
C
D
A
M
G
--------------
I
Q
Y
N
F
L
Q
P
--------
L
K
Q
G
------------------------------
L
S
-
F
--
E
S
F
F
D
D
------
E
T
M
S
L
H
I
K
E
D
T
V
--------------------
P
R
A
K
K
--
G
K
P
G
N
W
K
F
V
N
-
L
S
D
K
P
M
L
S
T
D
V
R
M
I
A
N
------------------------
E
I
I
N
A
V
R
L
I
K
-
G
S
F
V
E
I
E
R
R
G
S
L
I
I
Q
L
G
N
Y
R
V
V
I
T
---------------
R
P
P
L
S
D
G
W
E
I
T
I
T
R
P
V
V
R
--
K
R
L
E
D
Y
N
L
D
E
R
L
I
K
R
L
E
E
R
A
E
---
G
I
I
I
A
G
A
-
P
G
M
G
A
T
T
F
A
Q
A
L
A
E
Y
Y
------
M
------
R
-------------
L
G
K
I
V
K
--
T
I
--
E
S
P
R
D
M
H
L
P
P
--
E
I
--
T
Q
Y
S
K
N
Y
A
E
I
G
E
L
H
D
I
L
L
L
-
S
R
P
-
D
Y
T
V
Y
D
E
M
R
N
D
E
D
F
K
L
Y
V
D
L
R
L
A
G
--
V
G
M
V
G
V
V
H
A
T
S
P
I
D
A
I
------
H
R
-----
F
V
N
R
V
------------------
D
------
I
G
T
-
I
-
P
N
I
L
----------------
D
-------
T
--
I
I
F
I
N
S
G
-
N
V
S
K
V
Y
T
L
E
M
T
V
K
V
P
A
G
L
K
E
A
D
L
-
A
R
P
V
V
E
I
K
D
L
A
T
G
N
T
E
Y
E
I
Y
V
FGEQ
T
M
I
V
P
VNR
96
SP3
61.66
14%
31
- C5 -
-
1I2D
2
MET3_PENCH
A:
[2-573]
ANAPHGGVLKD
L
L
A
R
D
A
PR
Q
A
E
L
A
A
E
A
E
S
L
P
A
V
T
L
T
E
R
Q
L
C
D
L
E
L
I
M
N
GGFSPLEGFMN
Q
A
D
Y
D
R
V
C
E
DNRLADGNVFS
M
P
I
T
L
D
A
S
Q
E
V
I
D
E
K
K
L
Q
A
G
S
R
----
I
T
L
R
D
F
R
D
D
R
N
L
A
I
L
T
I
D
D
-
I
Y
R
P
D
K
T
K
E
A
K
L
V
FGGDP
E
H
P
A
I
-----------------
V
Y
L
N
N
T
V
---
K
E
------
F
Y
I
G
G
K
I
E
A
V
N
K
L
N
H
Y
D
Y
-------
V
A
L
R
Y
-
T
P
A
E
L
R
V
H
F
D
K
L
G
W
S
R
V
V
A
F
Q
T
RNPMH
R
A
H
R
E
L
T
V
R
A
A
R
S
R
Q
A
N
V
L
I
H
P
V
V
G
L
T
K
P
G
D
I
D
H
F
T
R
V
R
A
Y
Q
--------------
A
L
L
P
R
Y
P
N
GM
A
V
L
G
L
L
G
L
A
M
R
M
G
G
P
R
E
A
I
W
H
----------
A
I
I
R
K
--
N
H
G
A
-
T
--
H
F
I
V
G
R
DHAGPG
S
N
S
K
G
E
--
D
F
Y
G
P
Y
D
A
Q
H
A
V
E
K
Y
K
D
E
L
G
I
--
E
V
V
E
F
Q
M
V
T
Y
L
P
D
T
D
E
Y
R
P
V
D
Q
V
P
------
A
G
V
K
T
------------------------
L
N
I
S
G
T
E
L
R
R
R
L
R
S
-
G
A
H
I
P
E
-----------------------------------------
W
F
S
Y
P
E
--
V
V
K
I
L
R
E
S
N
P
-----
P
R
A
T
Q
G
---
F
T
I
F
L
T
G
Y
M
N
S
G
K
D
A
I
A
R
A
L
Q
V
T
L
N
Q
Q
GG
R
S
------
V
--
S
L
--
L
L
G
--
D
T
V
R
H
E
--------------
L
S
S
E
--
L
G
F
T
R
E
D
R
H
T
N
I
Q
R
I
A
F
V
A
T
E
L
T
-
R
A
G
-
A
A
V
I
A
A
P
I
A
P
Y
E
E
S
R
K
F
A
R
D
A
V
S
Q
A
G
-
S
F
F
L
V
H
V
A
T
P
L
E
H
C
E
Q
S
DKRG
I
Y
-----
A
A
A
R
R
-
G
E
I
-------
K
-
G
---
F
T
-------
G
V
-
D
-
D
P
Y
---
E
T
--
P
---
E
----
K
A
-------
D
--
L
V
V
D
F
S
K
Q
S
V
R
S
I
V
H
E
I
I
L
V
L
E
S
Q
G
-----
F
L
E
R
Q
------------------------------
120
HHSearch
56.82
23%
-94
- C5 -
-
2RHM
-
?
C:
[2-190]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
T
P
---
A
L
I
I
V
T
G
H
P
A
T
G
K
T
T
L
S
Q
A
L
A
T
G
L
------
R
------
L
--
P
L
--
L
S
K
--
D
A
F
K
E
V
M
F
--
D
G
L
G
W
S
-------
D
--
R
E
W
S
R
R
V
G
A
T
A
I
M
M
L
Y
H
T
A
A
T
I
L
-
Q
S
G
-
Q
S
L
I
M
E
S
N
F
R
V
D
L
D
T
E
R
M
Q
N
L
H
T
I
A
P
F
T
P
I
Q
I
R
C
V
A
S
G
D
V
L
V
------
E
R
-----
I
L
S
R
I
-
A
Q
G
ARHPGHC
D
-
D
RSP
A
D
------
L
E
L
-
V
-
R
S
R
G
D
-
I
P
--
P
---
L
PLG-
G
P
-------
L
--
L
T
V
D
T
T
F
-
P
E
Q
I
D
M
N
A
I
V
Q
W
V
R
Q
H
L
Q
S
G
T
------------------------------------
109
Fugue
54.68
16%
11
- C5 -
-
1YJ5
-
PNKP_MOUSE
A:
[5-383]
----------------------------------------------------------------------------------------------L
G
W
E
-
S
L
----
K
K
L
L
V
F
T
A
S
G
V
K
P
Q
G
K
V
A
A
-
F
D
L
D
G
T
L
I
T
T
R
S
------
G
K
V
F
P
-----------------
T
S
P
S
D
W
R
I
L
Y
P
----------
E
-----
I
P
K
K
L
Q
E
L
A
A
E
G
Y
K
L
V
I
F
T
N
Q
M
G
I
G
R
G
K
L
P
A
E
V
F
K
G
K
V
--------------
E
A
V
L
E
K
L
G
V
P
F
-
Q
V
L
V
A
T
H
A
G
L
--------------------------------------------------------------------------
N
R
K
--
P
V
S
G
M
W
--
D
H
L
Q
E
Q
------
A
N
E
G
I
P
I
S
------
V
E
D
S
V
F
-----
V
G
D
A
--
A
G
R
L
A
N
---
W
A
P
G
R
K
K
K
D
F
S
C
A
D
R
L
F
A
L
N
V
G
--------------------------------
L
P
F
A
T
P
E
E
F
F
L
K
W
P
A
A
R
F
--------------------------------------
E
L
P
A
F
D
P
R
--
T
I
S
S
A
G
P
L
Y
L
P
E
S
S
S
L
L
S
P
N
P
---
E
V
V
V
A
V
G
F
P
G
A
G
K
S
T
F
I
Q
E
H
L
V
S
A
------
G
------
Y
--
V
H
--
V
N
R
--
D
T
L
G
--------------------------------
S
W
Q
R
C
V
S
S
C
Q
A
A
L
-
R
Q
G
-
K
R
V
V
I
D
N
T
N
P
D
V
P
S
R
A
R
Y
I
Q
C
A
K
D
A
G
V
P
C
R
C
F
N
F
C
A
T
I
E
Q
A
R
------
H
N
-----
N
R
F
R
E
M
T
D
P
-------
S
-
H
---
A
P
------
V
S
D
M
V
M
F
S
Y
R
K
Q
F
E
--
P
---
P
----
T
L
-------
A
--
E
-------
G
F
L
E
I
L
E
I
P
F
R
L
Q
E
H
L
D
P
A
L
Q
R
L
Y
R
Q
F
S
E
G
---------------------------
118
Fugue
51.21
18%
-42
- C3 -
-
4MND
3
DIPPS_ARCFU
A:
[40-457]
---------------------------------------------------------------------------------------------------
L
M
----
K
A
V
I
L
A
A
G
L
G
G
G
V
P
K
P
L
V
R
-
V
G
G
C
E
-----------------------------------------------------
I
I
L
R
-----
T
M
K
L
L
S
P
H
--
V
S
E
F
I
I
V
A
S
R
Y
---
A
D
D
I
D
A
F
L
K
D
K
G
F
N
--------------
Y
K
I
V
R
-----------------
H
D
R
P
E
K
G
N
G
Y
S
L
L
V
A
K
N
--------------
H
V
E
D
R
F
I
L
--------
T
M
--
G
D
H
V
Y
S
Q
Q
F
I
E
----------
K
A
V
R
G
E
G
V
I
A
D
-
R
--
E
P
R
F
V
D
------
I
G
E
A
T
K
I
R
V
E
D
G
-----
R
V
A
-----
K
I
G
K
--
D
L
R
E
F
D
C
V
D
T
G
-
F
F
V
L
D
D
S
I
F
E
H
A
E
K
L
R
D
R
E
E
I
P
L
------------------------
S
E
I
V
K
L
A
R
L
P
V
T
Y
V
D
G
E
-----
L
W
M
D
V
D
T
K
E
D
V
R
----------------
R
A
N
R
A
---
L
V
S
A
A
V
G
D
G
F
--
I
S
R
K
I
N
R
K
I
S
T
R
I
S
A
A
I
V
N
K
V
N
P
N
Q
M
T
L
I
S
F
L
V
G
A
F
S
A
L
A
S
F
F
S
I
P
L
A
------
G
------
L
--
L
Y
--
Q
F
S
--
S
I
L
D
G
C
D
G
--
E
I
A
R
A
S
L
K
M
S
--
K
K
--
G
G
Y
V
D
S
I
L
D
R
F
V
D
F
L
F
L
A
I
I
A
L
L
Y
P
K
T
-
A
T
V
A
M
F
A
I
F
G
S
V
M
V
S
Y
T
S
E
K
Y
K
A
E
F
G
E
S
I
--------------------
R
-----
V
L
N
Y
I
-
P
G
K
-------
R
-
D
---
E
R
------
I
F
L
-
I
-
M
I
F
C
L
L
S
A
--
I
---
S
----
L
Q
-------
W
--
I
F
W
M
F
L
F
-
V
A
A
I
S
L
T
R
V
V
V
T
L
L
A
V
L
V
S
--------------------------------------
126
HHSearch
48.35
20%
-83
- C5 -
-
4EUN
-
?
A:
[28-195]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
---
R
H
V
V
V
M
G
V
S
G
S
G
K
T
T
I
A
H
G
V
A
D
E
T
------
G
------
L
--
E
F
--
A
E
A
--
D
A
F
H
S
P
E
N
--
I
A
T
M
Q
-------
R
G
--
I
P
L
T
D
E
D
R
W
P
W
L
R
S
L
A
E
W
M
D
A
R
A
-
D
A
G
-
V
S
T
I
I
T
C
S
A
L
K
R
T
Y
R
D
V
L
R
----
E
G
P
P
S
V
D
F
L
H
L
D
G
P
A
E
V
I
K
------
G
R
-----
M
S
K
R
E
-
G
H
F
-------------
M
P
------
A
S
L
-
L
-
Q
S
Q
L
A
T
L
E
--
A
LEP
D
----
E
S
-------
G
--
I
V
L
D
L
R
Q
-
P
P
E
Q
L
I
E
R
A
L
T
W
L
D
I
A
P
----------------------------------------
129
HHSearch
46.30
21%
-94
- C5 -
-
3T61
-
?
A:
[15-186]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
F
P
---
G
S
I
V
V
M
G
V
S
G
S
G
K
S
S
V
G
E
A
I
A
E
A
C
------
G
------
Y
--
P
F
--
I
E
G
--
D
A
L
H
P
P
E
N
--
I
R
K
M
S
E
-------
G
--
I
P
L
T
D
D
D
----
R
W
P
W
L
A
A
I
G
E
R
L
-
A
S
R
-
E
P
V
V
V
S
C
S
A
L
K
R
S
Y
R
D
K
L
R
E
S
A
---
P
G
G
L
A
F
V
F
L
H
G
S
E
S
V
L
A
------
E
R
-----
M
H
H
R
T
-
G
H
F
-------------
M
P
------
S
S
L
-
L
-
Q
T
Q
L
E
T
L
E
--
D
---
P
RGE-
V
R
-------
T
--
V
A
V
D
V
A
Q
-
P
L
A
E
I
V
R
E
A
L
A
G
L
A
R
L
A
E
N
L
Y
F
-----------------------------------
128
HHSearch
46.26
21%
-91
- C5 -
-
3T61
-
?
B:
[15-186]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
F
P
---
G
S
I
V
V
M
G
V
S
G
S
G
K
S
S
V
G
E
A
I
A
E
A
C
------
G
------
Y
--
P
F
--
I
E
G
--
D
A
L
H
P
P
E
N
--
I
R
K
M
S
E
-------
G
--
I
P
L
T
D
D
D
----
R
W
P
W
L
A
A
I
G
E
R
L
-
A
S
R
-
E
P
V
V
V
S
C
S
A
L
K
R
S
Y
R
D
K
L
R
E
S
A
---
P
G
G
L
A
F
V
F
L
H
G
S
E
S
V
L
A
------
E
R
-----
M
H
H
R
T
-
G
H
F
-------------
M
P
------
S
S
L
-
L
-
Q
T
Q
L
E
T
L
E
--
D
---
P
RGE-
V
R
-------
T
--
V
A
V
D
V
A
Q
-
P
L
A
E
I
V
R
E
A
L
A
G
L
A
R
L
A
E
N
L
Y
F
-----------------------------------
104
Fugue
45.78
19%
-80
- C5 -
-
1KNQ
-
GNTK_ECOLI
A:
[3-173]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
N
H
D
H
---
H
I
Y
V
L
M
G
V
S
G
S
G
K
S
A
V
A
S
E
V
A
H
Q
L
------
H
------
A
--
A
F
--
L
D
G
--
D
F
L
H
---------
P
R
R
N
I
E
K
M
A
S
G
--
E
P
L
N
D
D
D
R
K
P
W
L
Q
A
L
N
D
A
A
F
A
M
Q
-
R
T
N
-
K
V
S
L
I
V
C
S
----
A
L
K
K
H
Y
R
D
L
L
R
E
G
N
P
N
L
S
F
I
Y
L
K
G
D
F
D
V
I
E
------
S
R
-----
L
K
A
R
K
-
G
H
F
-------
F
-
K
---
T
Q
------
M
L
V
-
T
-
Q
F
E
T
L
Q
E
P
GA
D
---
E
----
T
D
-------
V
--
L
V
V
D
I
D
Q
-
P
L
E
G
V
V
A
S
T
I
E
V
I
K
K
------------------------------------------
115
Fugue
43.40
21%
-83
- C5 -
-
1SHK
-
AROL_DICCH
A:
[1-173]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
E
---
P
I
F
M
V
G
-
A
R
G
C
G
K
T
T
V
G
R
E
L
A
R
A
L
------
G
------
Y
--
E
F
--
V
D
T
--
D
I
F
M
Q
H
T
S
--
G
---
M
T
V
A
D
V
V
A
A
E
--
G
-------
W
P
G
F
R
R
R
E
S
E
A
L
Q
A
V
-
A
T
P
-
N
R
V
V
A
-
T
G
G
G
M
V
L
L
E
Q
N
R
Q
F
M
R
A
H
G
----
T
V
V
Y
L
F
A
P
A
E
E
L
A
------
L
R
-----
L
Q
I
--------------------
A
------
E
E
M
-
E
-
A
V
L
R
E
R
E
A
--
L
---
Y
----
Q
D
-------
V
AH
Y
V
V
D
A
T
Q
-
P
P
A
A
I
V
C
E
L
M
Q
T
M
R
L
P
A
A
---------------------------------------
111
Fugue
42.73
21%
-83
- C5 -
-
1SHK
-
AROL_DICCH
A:
[1-173]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
E
---
P
I
F
M
V
G
-
A
R
G
C
G
K
T
T
V
G
R
E
L
A
R
A
L
------
G
------
Y
--
E
F
--
V
D
T
--
D
I
F
M
Q
H
T
S
--
G
---
M
T
V
A
D
V
V
A
A
E
--
G
-------
W
P
G
F
R
R
R
E
S
E
A
L
Q
A
V
-
A
-
T
-
P
N
R
V
V
A
T
G
G
G
M
V
L
L
E
Q
N
R
Q
F
M
R
A
H
G
----
T
V
V
Y
L
F
A
P
A
E
E
L
A
------
L
R
-----
L
-----------------
Q
---
I
A
------
E
E
M
-
E
-
A
V
L
R
E
R
E
A
--
L
---
Y
----
Q
D
-------
V
AH
Y
V
V
D
A
T
Q
-
P
P
A
A
I
V
C
E
L
M
Q
T
M
R
L
P
A
A
---------------------------------------
139
HHSearch
42.30
19%
-36
- C5 -
-
1KNQ
-
GNTK_ECOLI
A:
[5-173]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
H
D
H
---
H
I
Y
V
L
M
G
V
S
G
S
G
K
S
A
V
A
S
E
V
A
H
Q
L
------
H
------
A
--
A
F
--
L
D
G
--
D
F
L
H
P
R
R
N
--
I
E
K
M
A
S
-------
G
--
E
P
L
N
D
D
D
R
K
P
W
L
Q
A
L
N
D
A
A
F
A
M
Q
-
R
T
N
K
V
S
L
I
V
C
S
A
L
-
K
K
H
Y
R
D
L
L
R
----
E
G
N
P
N
L
S
F
I
Y
L
K
G
D
F
D
V
I
E
------
S
R
-----
L
K
A
R
K
-
G
H
F
-------------
F
K
------
T
Q
M
-
L
-
V
T
Q
F
E
T
L
Q
--
E
---
P
GADE
T
D
-------
V
--
L
V
V
D
I
D
Q
-
P
L
E
G
V
V
A
S
T
I
E
V
I
K
K
------------------------------------------
124
HHSearch
41.42
19%
23
- C5 -
-
4BZP
5
?
A:
[2-173]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
R
G
---
K
T
V
W
F
T
G
L
S
G
S
G
K
S
S
V
A
M
L
V
E
R
K
L
L
E
K
GI-
S
------
A
--
Y
V
--
L
D
G
--
D
N
L
R
H
G
L
N
--
A
D
L
G
F
S
--------------
M
A
D
R
A
E
N
L
R
R
L
S
H
V
A
T
L
L
A
-
D
C
G
-
H
L
V
L
V
P
A
I
S
P
L
A
E
H
R
A
L
A
R
K
V
H
A
D
A
G
I
D
F
F
E
V
F
C
D
T
P
L
Q
D
C
E
------
R
R
-----
D
P
K
G
L
-
Y
A
K
-------
A
-
R
A
--
G
E
------
I
T
H
-
F
-
T
G
I
D
S
P
Y
Q
--
R
---
P
K---
N
P
-------
D
--
L
R
L
T
P
D
R
-
S
I
D
E
Q
A
Q
E
V
I
D
L
L
E
-------------------------------------------
123
HHSearch
41.20
19%
34
* C5 *
-
4BZQ
4
B:
[2-172]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
G
---
K
T
V
W
F
T
G
L
S
G
S
G
K
S
S
V
A
M
L
V
E
R
K
L
LEKGI-
S
------
A
--
Y
V
--
L
D
G
--
D
N
L
R
H
G
L
N
--
A
D
L
G
F
S
--------------
M
A
D
R
A
E
N
L
R
R
L
S
H
V
A
T
L
L
A
-
D
C
G
-
H
L
V
L
V
P
A
I
S
P
L
A
E
H
R
A
L
A
R
K
V
H
A
D
A
G
I
D
F
F
E
V
F
C
D
T
P
L
Q
D
C
E
------
R
R
-----
D
P
K
G
L
-
Y
A
K
-------
A
-
R
A--
G
E
------
I
T
H
-
F
-
T
G
I
D
S
P
Y
Q
--
R
---
P
K---
N
P
-------
D
--
L
R
L
T
P
D
R
-
S
I
D
E
Q
A
Q
E
V
I
D
L
L
E
-------------------------------------------
136
HHSearch
39.88
17%
15
- C5 -
-
5CB8
1
CYSC_SYNY3
A:
[23-193]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
G
---
V
T
I
W
L
T
G
L
S
G
A
G
K
T
T
I
T
H
A
L
E
K
K
L
------
R
D
S
G
Y
R
-
L
--
E
V
--
L
D
G
--
D
V
V
R
T
N
L
T
--
K
G
L
G
F
S
-------
K
--
E
D
R
-----
D
T
N
I
R
R
I
G
F
V
S
H
L
L
T
-
R
N
G
-
V
I
V
L
V
S
A
I
S
P
Y
A
A
I
R
Q
E
V
K
H
T
----
I
G
D
F
L
E
V
F
V
N
A
P
L
A
V
C
E
------
E
R
-----
D
V
K
G
L
-
Y
A
K
-------
A
R
S
---
G
E
------
I
K
G
-
F
-
T
G
I
D
D
P
Y
E
--
P
---
P
T---
N
P
-------
D
--
V
E
C
R
T
D
L
E
E
L
D
E
S
V
G
K
I
W
Q
K
L
V
D
L
K
----------------------------------------
137
HHSearch
39.46
17%
18
- C5 -
-
5CB8
1
CYSC_SYNY3
B:
[22-193]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
R
G
---
V
T
I
W
L
T
G
L
S
G
A
G
K
T
T
I
T
H
A
L
E
K
K
L
------
R
D
S
G
Y
R
-
L
--
E
V
--
L
D
G
--
D
V
V
R
T
N
L
T
--
K
G
L
G
F
S
-------
K
--
E
D
R
-----
D
T
N
I
R
R
I
G
F
V
S
H
L
L
T
-
R
N
G
-
V
I
V
L
V
S
A
I
S
P
Y
A
A
I
R
Q
E
V
K
H
T
----
I
G
D
F
L
E
V
F
V
N
A
P
L
A
V
C
E
------
E
R
-----
D
V
K
G
L
-
Y
A
K
-------
A
R
S
---
G
E
------
I
K
G
-
F
-
T
G
I
D
D
P
Y
E
--
P
---
P
T---
N
P
-------
D
--
V
E
C
R
T
D
L
E
E
L
D
E
S
V
G
K
I
W
Q
K
L
V
D
L
K
----------------------------------------
94
SP3
39.05
6%
-77
- C5 -
-
1KNQ
-
GNTK_ECOLI
A:
[3-173]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
N
H
D
H
---
H
I
Y
V
L
M
G
V
S
G
S
G
K
S
A
V
A
S
E
V
A
H
Q
L
------
H
------
A
--
A
F
--
L
D
G
--
D
F
L
H
P
R
R
N
--
I
E
K
M
A
S
G
E
P
---------
L
N
D
D
D
R
K
P
W
L
Q
A
L
N
D
A
A
F
A
M
Q
-
R
T
N
-
K
V
S
L
I
V
C
S
A
L
K
K
H
Y
R
D
L
L
R
E
----
G
N
P
N
L
S
F
I
Y
L
K
G
D
F
D
V
I
E
------
S
R
-----
L
K
A
R
K
-
G
H
F
-------
F
-
K
---
T
Q
M
L
----
V
T
Q
-
F
-
E
T
L
Q
E
P
G
A
--
D
---
E
----
T
D
-------
V
--
L
V
V
D
I
D
Q
-
P
L
E
G
V
V
A
S
T
I
E
V
I
K
K
------------------------------------------
97
SP3
38.30
6%
38
- C5 -
-
1QF9
2
KCY_DICDI
A:
[1-194]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
K
S
K
P
---
N
V
V
F
V
L
G
G
P
G
S
G
K
G
T
Q
C
A
N
I
V
R
D
F
------
G
------
W
--
V
H
--
L
S
A
--
G
D
L
L
R
Q
E
Q
Q
S
G
S
K
D
G
E
M
I
A
T
M
I
K
N
--
G
E
I
V
P
S
--
I
V
T
V
K
L
L
K
N
A
I
D
A
---
N
Q
G
-
K
N
F
L
V
D
G
F
P
R
N
E
E
N
N
N
S
W
E
E
N
M
K
D
F
V
D
T
K
F
V
L
F
F
D
C
P
E
E
V
M
T
------
Q
R
-----
L
L
K
R
G
-
E
S
S
-------
G
-
R
---
S
D
DN
I
E
S
I
K
K
R
-
F
-
N
T
F
N
V
Q
T
K
--
L
---
V
----
I
D
H
Y
N
K
F
DK
V
--
K
I
I
P
A
N
R
-
D
V
N
E
V
Y
N
D
V
E
N
L
F
K
S
M
G
F
---------------------------------------
106
Fugue
38.23
16%
-22
- C5 -
-
1QHX
1
CPT_STRVP
A:
[1-178]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
T
---
R
M
I
I
L
N
G
G
S
S
A
G
K
S
G
I
V
R
C
L
Q
S
V
L
------
P
------
E
--
P
W
--
L
A
F
G
V
D
S
L
I
E
A
M
P
--
L
K
M
Q
S
A
E
G
G
I
E
F
D
A
DG
G
V
S
I
G
P
E
F
R
A
L
E
G
A
W
A
E
G
V
V
A
M
A
-
R
A
G
-
A
R
I
I
I
D
D
V
F
L
G
G
A
A
A
Q
E
R
W
R
S
F
V
G
D
-
L
D
V
L
W
V
G
V
R
C
D
G
A
V
A
E
------
G
R
-----
E
T
A
R
---
G
D
-------
R
-
V
---
A
G
------
M
A
A
-
K
-
Q
A
Y
V
V
H
E
G
--
V
---
E
----
Y
D
-------
V
--
E
V
D
T
T
H
K
-
E
S
I
E
C
A
W
A
I
A
A
H
V
V
P
------------------------------------------
138
HHSearch
36.80
17%
24
- C5 -
-
2PEZ
2
PAPS1_HUMAN
A:
[4-176]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
---
C
T
V
W
L
T
G
L
S
G
A
G
K
T
T
V
S
M
A
L
E
E
Y
L
V
C
H
---
G
------
I
P
C
Y
T
--
L
D
G
--
D
N
I
R
Q
G
L
N
--
K
N
L
G
F
S
--------------
P
E
D
R
E
E
N
V
R
R
I
A
E
V
A
K
L
F
A
-
D
A
G
-
L
V
C
I
T
S
F
I
S
P
Y
T
Q
D
R
N
N
A
R
Q
I
H
E
G
A
S
L
P
F
F
E
V
F
V
D
A
P
L
H
V
C
E
------
Q
R
-----
D
V
K
G
L
-
Y
K
K
A
------
R
-
A
---
G
E
------
I
K
G
-
F
-
T
G
I
D
S
E
Y
E
--
K
---
P
E---
A
P
-------
E
--
L
V
L
K
T
D
S
C
D
V
N
D
C
V
Q
Q
V
V
E
L
L
Q
E
R
-----------------------------------------
127
HHSearch
35.97
17%
30
- C5 -
-
2OFX
2
PAPS1_HUMAN
A:
[29-204]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
R
G
---
C
T
V
W
L
T
G
L
S
G
A
G
K
T
T
V
S
M
A
L
E
E
Y
L
V
C
H
---
G
------
I
--
P
C
Y
T
L
D
G
--
D
N
I
R
Q
G
L
N
--
K
N
L
G
F
S
--------------
P
E
D
R
E
E
N
V
R
R
I
A
E
V
A
K
L
F
A
-
D
A
G
-
L
V
C
I
T
S
F
I
S
P
Y
T
Q
D
R
N
N
A
R
Q
I
H
E
G
A
S
L
P
F
F
E
V
F
V
D
A
P
L
H
V
C
E
------
Q
R
-----
D
V
K
G
L
-
Y
K
K
A
------
R
-
A
---
G
E
------
I
K
G
-
F
-
T
G
I
D
S
E
Y
E
--
K
---
P
E---
A
P
-------
E
--
L
V
L
K
T
D
S
C
D
V
N
D
C
V
Q
Q
V
V
E
L
L
Q
E
R
D
----------------------------------------