@TOME V3
(Feb 2022)
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-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : D1A4X4_THECD: (2019-01-27 )
MNAHVPSGPDELTPEWLSRALGAEVTSVSWERVGSGQIGACYRLTLKGEEKVPARLVAKMASEDPTTRAFLASAYRTEVLFYRDVVPTVAVRTPRCHYQAIADDNSAFVLLLEDMAPAEQGDQLAGCTPQQAAAAVTNLAGLHGPRWCDKTLTEIPWLSVVTEDDAAVLTEVFAPAVDAFVQRFTGRLSDEDIDTLRRVADRIAAWAVARPERFGLVHGDYRLDNLLFAPPPQQTVTAVDWQTLSIGHPVRDLSFFLGTAMDPAERSAHERALVETYHTALTGYGVDDYDLQSCWEDYRFGALQGPLITVLGCAVGTPTERGDRMFLAMTRRSCAAIRELGSLELI
Atome Classification :
(21 SA)
----------.........10..--...-...20.---.-.---..-.-----.-.30--........-40........----50--....-.....-60........70..-.......80...-....-.90.---...-....100.---------.--.....110---------.-.--------.......120-...---------.-..----.----130--...----...--..140-..----.....150..-.....160..-...-..170-...-.-...180..---------.----------....--190-.------.......200...--------.----.--..---.210---....-.....220....------.-..230--.-......-240---........-250...-.-------------...260-----------.------..------..--.---------------..-----------.-----------270.-.....-----.--280.......290...-...-...300-.....-..-.310.......------------------320.---......330..-......340....------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------MNAHVPSGPDEL
T
--
P
E
W
-
L
S
R
A
LG---A-E---VT-
S
-----
V
-
S
W
E
--RVGSGQ
I
G
-
A
C
Y
R
L
T
LKGE----E---K
V
P
A
-
R
L
V
A
K
-
M
ASEDP
T
T
R
A
F
-
L
A
-
S
A
Y
R
T
E
V
L
F
Y
RD-VV
P
T
-VAVR---TPR-
C
H
Y
Q
A
IAD---------D--N
S
A
F
V
L
-----------
L
-L--------EDMAPAEQGD-QLA---------G-C
T
----
P
----
Q
Q
---
A
A
A
----
A
V
T
--
N
L
AGL-HG----PR
W
C
D
K
T
L
TE-IP
W
L
S
V
VTED-
D
A
A
-
V
L
T
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V
-
F
A
P
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---------T----------GRLS--DE--
D
------
I
D
T
L
R
R
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A
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R
I
A
--------
A
----
W
--AV---AR-----PERF-G
L
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HGDYRLDNL------L-FAPPP--Q-
Q
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----
Q
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LSIGHP-
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-------------LGTA-------------M------
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YRF-G-ALQG
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GCAVGTPT------------------ERG
D
---
R
M
F
L
A
M
T
R
-
R
S
-
C
A
A
I
R
E
LGSLELI------------------------
61
Fugue
79.41
22%
-8
- C5 -
-
3CSV
11
?
A:
[4-333]
-----------------
S
R
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R
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---
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A
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A
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51
Fugue
71.23
17%
13
* C5 *
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
-----------------
T
L
P
A
V
I
--
S
R
W
-
L
S
S
V
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P
---
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-----------
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Q
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H
F
G
E
I
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------------------
P
D
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-------
V
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L
F
-
Y
H
-
A
G
L
M
K
H
L
L
G
E
E
H
-------------------------
62
Fugue
70.74
16%
-29
- C5 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
--------------
S
A
F
T
F
Q
T
L
H
--
P
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---
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---
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-----
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V
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Q
F
Q
D
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D
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----
R
--------
R
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Y
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Q
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L
-
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A
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---
A
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---
N
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L
L
N
---------
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----
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A
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N
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A
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M
-
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-------------
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N
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---------------------
D
K
------
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---------------
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M
-----------
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L
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A
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-----
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------------------
L
T
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---
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A
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Q
LTPMY-------------------
19
HHSearch
65.24
20%
9
- C5 -
-
3ATT
2
Y3168_MYCTU
A:
[4-297]
--------------------
A
V
I
--
S
R
W
-
L
S
S
V
L
P
G--
G
-
A
---
A
P
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-----
V
-
T
V
E
SG
V
D
S
T
G
M
S
S
-
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I
I
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A
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W
Q
----
Q
DG
R
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Q
-
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---
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T
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---------
D
V-
L
G
T
P
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-----------
L
-
M
--------
D
Y
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-
V
M
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YTFGDNWFA
D
-
A
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----
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---
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D
A
----
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A
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A
L
A
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L
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H
S
----
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P
N
A
Q
N
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F
----
S
F
L
T
-------
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T
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T
L
H
R
H
-
F
-
N
-
W
-
V
R
S
W
Y
D
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A
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V
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E
G
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--------
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A
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F
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H
-------------
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--
L
---------------
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L
A
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R
-----------
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D
D
V
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A
T
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Q
-----
A
--
L
-------------------------------------------------------------------------------------------------------------------------
20
HHSearch
64.57
20%
7
- C5 -
-
3ATS
1
Y3168_MYCTU
A:
[4-297]
--------------------
A
V
I
--
S
R
W
-
L
S
S
V
L
P
G--
G
-
A
---
A
P
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V
-
T
V
E
SG
V
D
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G
M
S
S
-
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I
L
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A
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----
Q
DG
R
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---
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V-
L
G
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-----------
L
-
M
--------
D
Y
V
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V
V
P
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D
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V
M
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D
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A
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----
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----
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A
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A
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I
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N
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----
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F
L
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-------
D
T
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F
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Y
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G
----
I
G
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-------------
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F
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H
-------------
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------
V
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------
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--
L
---------------
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L
A
TLPGLPEVM
R
-----------
E
D
D
V
-
R
A
T
Y
Q
-----
A
--
L
-------------------------------------------------------------------------------------------------------------------------
52
Fugue
61.36
12%
-54
- C5 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
--------------
K
T
P
L
Y
E
T
L
N
--
E
S
S
-
A
V
A
L
A
V
---
K
-
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---
G
L
-
T
-----
L
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--
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---
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---
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---------
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--
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-----------
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-
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--------
K
G
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E
G
E
N
Y
P
-
H
L
S
---------
Q
-
H
I
----
G
----
E
F
---
L
G
K
----
T
L
F
--
Y
S
S
D
Y
A
L
E
----
P
K
V
K
K
Q
L
V
K
Q
-
F
T
N
P
E
L
C
D
I
T
-
E
R
L
-
V
F
T
D
P
-
F
F
D
-
H
D
T
N
D
F
E
E
E
L
---------
R
----------
P
F
V
E
--
K
L
W
-
N
------
N
D
S
V
K
I
E
A
A
-
K
L
K
--------
K
----
S
--
F
L
---
T
S
-----
A
E
---
T
L
I
H
G
D
L
H
T
G
S
I
------
F
-
A
S
E
H
E
------
T
K
V
I
-
D
P
----
E
F
A
F
Y
G
P
I
-
G
F
D
V
G
Q
-
F
-------------
I
A
N
L
-------------
F
------
L
N
------
A
L
--
S
R
DGADR
E
P
L
Y
E
H
V
--
N
Q
-----------
V
-----------
W
E
T
F
-
E
E
T
F
S
-----
E
--
A
W
Q
K
D
S
L
D
V
Y
A
--
N
I
D
-
G
Y
L
-
T
D
T
L
-
S
-
H
I
F
E
E
-
A
I
-
G
F
A
G
C
E
L
I
R
R
T
IGLAHV
A
D
L
D
T
IVP
F
D
K
R
I
G
R
K
---
R
L
A
L
E
T
G
T
-
A
F
-
I
E
K
R
S
E
F
K
T
I
T
D
V
I
E
L
F
K
L
L
V
K---------------
60
Fugue
60.82
11%
-67
- C5 -
-
3HAM
3
?
A:
[1-299]
----------
M
V
N
L
D
A
E
I
Y
E
H
L
N
--
K
Q
I
-----------------
K
-
I
-----
N
-
E
L
R
--
Y
L
S
S
G
D
D
S
-
D
T
F
L
C
N
E
Q
Y
V
----
V
---
K
V
P
K
--------------------
R
-
D
S
V
R
I
S
Q
K
R
E
F
E
-
L
Y
R
F
-
L
E
N
C
---
K
L
S
-
Y
Q
I
P
A
V
V
Y
---------
Q
--
S
D
R
F
N
I
-----------
M
-
K
--------
Y
I
K
G
E
R
I
T
Y
E
-
Q
Y
H
---------
K
-
L
S
----
E
----
K
E
---
K
D
A
----
L
A
Y
--
D
E
A
T
F
-
L
K
----
E
L
H
S
I
E
I
-
D
C
-
S
V
S
L
F
S
D
A
L
V
-
N
K
K
-
D
K
F
L
Q
-
D
K
K
-
L
-
L
I
S
I
L
E
K
----------
E
----------
Q
L
L
T
--
D
E
--
M
------
L
E
H
I
E
T
I
Y
E
-
N
I
L
--------
N
----
N
--
A
V
---
L
F
-----
K
Y
T
P
-
C
L
V
H
N
D
F
S
A
N
N
M
------
I
-
F
R
-----
N
-
N
R
L
F
G
V
I
D
F
----
G
D
F
N
V
G
D
P
-
D
N
D
F
L
C
-
L
-------------
L
-
D
C
-------------
S
------
T
D
------
D
F
--
G
---------------
K
E
-----------
F
-----------
G
R
K
V
-
L
K
Y
Y
Q
-----
H
--
K
A
-----------
P
E
V
-
A
E
R
-
K
A
E
L
-
N
-
D
V
Y
W
S
-
I
D
-
Q
I
I
Y
G
Y
E
R
K
D
R
------------------
E
M
L
I
---
K
G
V
S
E
L
L
Q
-
T
Q
-
A
E
M
F
I
F
-------------------------------
57
Fugue
57.15
12%
-37
- C5 -
-
3I1A
2
?
A:
[3-330]
--------------
K
Q
P
I
Q
A
Q
Q
L
--
I
E
L
-
L
K
V
H
Y
G
---
I
-
D
---
I
H
-
T
-----
A
-
Q
F
I
--
Q
G
G
A
D
T
N
A
-
F
A
Y
Q
A
D
S
E
S
K
-------------
S
Y
F
I
K
-
L
K
Y
G
Y
H
D
E
I
N
L
-
S
I
-
I
R
L
L
H
D
-
S
G
I
K
E
-
I
I
F
P
-
I
H
T
L
---
E
A
K
-
L
F
Q
Q
---
L
---------
K
--
H
F
K
I
I
A
-----------
Y
-
P
--------
F
I
H
A
P
N
G
F
T
Q
-
N
L
-------------
T
----
G
----
K
Q
---
W
K
Q
----
L
G
K
--
V
L
R
Q
I
-
H
E
T
S
V
P
I
S
I
Q
Q
Q
L
R
K
E
-
I
Y
S
P
K
W
R
E
I
V
-
R
S
F
-
Y
N
Q
I
E
-
F
D
N
-
S
-
D
D
K
L
T
A
A
F
---------
K
----------
S
F
F
N
Q
N
S
A
--
A
------
I
H
R
L
V
D
T
S
E
-
K
L
S
--------
K
----
K
--
I
Q
---
P
D
-----
L
D
K
Y
-
V
L
C
H
S
D
I
H
A
G
N
V
------
L
-
V
--
G
N
--
E
-
E
S
I
Y
I
I
-
D
W
----
D
E
P
M
L
A
P
K
-
E
R
D
L
M
F
-
I
-------------
G
G
G
V
-------------
G
------
N
V
------
W
N
--
K
---------------
P
H
-----------
E
-----------
I
Q
Y
F
-
Y
E
G
Y
G
-----
E
----
I
N
V
D
K
T
I
L
S
--
Y
Y
R
-
H
E
R
-
I
V
E
D
-
I
-
A
V
Y
G
Q
-
D
L
-
L
S
R
N
Q
N
N
Q
S
R
L
------------------
E
S
F
K
---
Y
F
K
E
M
F
D
P
-
N
N
-
V
V
E
I
A
F
A
T
E
----------------------------
41
SP3
56.67
10%
7
- C5 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
MD
L
D
T
D
A
N
T
I
P
E
L
K
E
R
A
H
M
L
-
C
A
R
F
L
G
---
G
-
A
---
W
K
-
T
VPLEH
L
-
R
I
S
--
R
I
K
G
G
M
S
N
-
M
L
F
L
C
R
L
S
E
V
YPPI
R
---
N
E
P
N
-
K
V
L
L
R
-
V
Y
F
N
P
E
T
------
E
-
S
H
L
V
A
E
S
V
I
F
T
L
-
L
S
E
---
R
H
L
---
G
P
K
-
L
Y
G
I
F
S
G
------------------
G
-----------
R
-
L
--------
E
E
Y
I
P
S
R
P
L
S
-
C
H
E
---------
I
-
S
L
----
A
----
H
M
---
S
T
K
----
I
A
K
--
R
V
A
K
V
-
H
Q
----
L
E
----------
V
P
I
W
K
E
P
D
Y
-
L
C
E
-
A
L
Q
R
W
-
L
K
Q
-
L
-
T
G
T
V
D
A
E
H
---------
R
----------
F
D
L
P
--
E
E
--
C
GVSSVN
C
L
D
L
A
R
E
L
E
-
F
L
R
--------
A
----
H
--
I
S
---
L
S
-----
K
S
P
V
-
T
F
C
H
N
D
L
Q
E
G
N
I
------
L
-
L
P
-------
K
R
L
V
L
I
-
D
F
----
E
Y
A
S
Y
N
Y
R
-
A
F
D
F
A
N
-
H
-------------
F
I
E
W
T
IDYDIDEAPF
Y
K
I
------
Q
T
------
E
N
FP
E
---------------
N
D
-----------
Q
-----------
M
L
E
F
-
F
L
N
Y
L
-----
R
--
E
Q
G
N
T
R
E
N
E
L
Y
K
K
S
E
D
-
L
V
Q
-
E
T
L
P
F
V
-
P
V
S
H
F
-
F
W
-
G
V
W
G
L
L
Q
V
E
L
S
------------------
P
V
G
F
---
G
F
A
D
Y
G
R
D
-
R
L
-
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A-----------------------
59
Fugue
56.65
10%
11
- C5 -
-
2QG7
-
?
A:
[50-458]
-------YPI
T
E
S
N
L
R
I
L
E
G
E
D
R
--
S
E
K
-
A
K
E
L
L
K
---
K
-
Y
---
V
S
N
V
-----
F
-
E
N
E
--
K
T
L
Y
I
Y
C
K
-
Y
V
M
L
H
Y
G
K
D
L
----
V
---
N
P
N
E
-
V
D
S
L
E
-
F
Q
I
I
N
G
T
N
I
L
I
-
K
V
-
K
D
M
S
K
Q
A
K
Y
L
I
R
-
L
Y
G
P
-
T
D
E
I
---
I
N
R
-
E
R
E
K
K
I
S
C
---------
I
--
L
Y
N
K
N
I
A
K
K
I
Y
V
FFTN
G
R
-
I
--------
E
E
F
M
D
G
Y
A
L
S
-
R
E
D
---------
I
-
K
N
----
P
----
K
F
---
Q
K
L
----
I
A
K
--
N
L
K
L
L
-
H
D
----
I
K
L
N
E
N
L
Y
K
E
-
L
Q
V
T
Q
K
V
P
G
T
-
R
P
S
-
F
L
W
N
T
-
I
W
K
-
Y
-
F
H
L
L
N
E
E
R
K
KICSFDAK
A
----------
N
I
L
K
--
L
I
--
D
------
F
D
V
L
R
D
S
I
V
-
E
V
E
--------
S
----
L
--
C
K
---
R
E
-----
N
S
P
I
-
V
L
C
H
C
D
L
L
S
S
N
I
------
I
-
N
T
V
G
E
--
G
-
D
S
I
S
F
I
-
D
F
----
E
Y
S
C
P
M
E
R
-
A
Y
D
I
A
N
-
H
-------------
F
N
E
Y
-------------
A
GFNCDW
D
L
------
T
P
--
S
---------------
K
E
-----------
E
-----------
E
Y
H
F
-
I
M
H
Y
L
-----
G
--
T
D
-----
D
E
E
L
--
I
N
Q
-
L
I
R
-
E
I
Q
P
-
F
-
Y
I
C
S
H
-
I
N
-
W
G
L
W
S
L
L
Q
G
M
H
------------------
S
F
D
F
---
I
N
Y
G
M
T
R
L
-
T
A
-
S
C
L
P
I
F
R
S
K
V
---------------------------
56
Fugue
56.06
13%
-10
- C5 -
-
2Q83
5
COTI_BACSU
A:
[11-346]
----------
L
S
A
E
D
A
K
K
L
T
E
L
A
--
E
N
V
-
L
Q
G
-
W
D
---
V
-
Q
---
A
E
-
K
-----
I
-
D
V
I
--
Q
------
A
-
L
V
W
K
V
H
T
D
S
G
----
A
---
V
C
L
K
-
R
I
--------
H
R
P
E
K
K
A
-
L
F
-
S
I
F
A
Q
D
Y
L
A
K
K
G
M
N
V
P
G
-
I
-
L
P
---
N
K
K
-
G
S
L
Y
S
K
H
G
---------
S
--
F
L
F
V
V
Y
-----------
D
-
W
--------
I
E
G
R
P
F
E
L
T
V
-
K
Q
D
---------
L
-
E
F
----
I
M
---
K
G
---
L
A
D
----
F
H
T
--
A
S
V
G
Y
-
Q
P
----
P
N
G
V
P
I
F
T
K
L
-
G
R
W
P
N
H
Y
T
K
R
-
C
K
Q
M
E
T
W
K
L
M
A
E
A
-
E
-
K
E
D
P
F
S
Q
L
---------
Y
----------
L
Q
E
I
--
D
G
--
F
------
I
E
D
G
L
R
I
K
D
-
R
L
L
Q
ST
Y
V
---
P
----
W
--
T
E
---
Q
L
-----
K
K
S
P
-
N
L
C
H
Q
D
Y
G
T
G
N
T
------
L
-
L
--
G
E
--
N
-
E
Q
I
W
V
I
-
D
L
----
D
T
V
S
F
D
L
P
-
I
R
D
L
R
K
M
I
-------------
I
P
L
L
-------------
D
------
T
T
------
G
V
--
W
---------------
D
D
-----------
E
-----------
T
F
N
V
M
L
N
A
Y
E
-----
S
--
R
---
A
P
L
T
E
E
Q
--
K
Q
V
M
F
------
I
-
D
M
L
F
P
Y
E
-
L
Y
-
D
V
I
R
E
K
Y
V
R
K
S
------------------
A
L
P
K
---
E
E
L
E
S
A
F
E
-
Y
E
-
R
I
K
A
N
A
L
R
Q
L
I
--------------------------
30
HHSearch
54.24
16%
13
- C5 -
-
4DCA
1
?
A:
[25-270]
---------------------
L
D
--
A
E
I
-
Y
E
H
L
N
K
Q
--
I
-
K
---
I
N
-
E
--------
L
R
--
Y
L
S
S
G
D
D
S
-
D
T
F
L
C
--
N
-------------
E
-
Q
Y
V
V
K
-
V
P
K
R
D
S
------
V
R
-
I
S
Q
K
R
E
L
E
L
Y
R
F
-
L
E
N
C
K
L
S
Y
Q
---
I
P
A
-
V
V
Y
Q
S
-----------------
D
R
F
N
-----------
I
-
M
--------
K
Y
I
K
G
E
R
I
T
Y
E
Q
Y
H
---------
K
-
L
S
E
K
E
K
D
----
A
L
---
A
Y
D
----
E
A
T
--
F
L
K
E
L
-
H
S
----
I
E
I
D
C
S
V
S
----
L
F
S
D
A
L
V
N
K
-
K
D
--
K
F
L
Q
D
-
K
-
K
-
L
-
L
I
S
I
L
E
K
----------
E
----------
Q
L
L
T
--
D
E
--
M
------
L
E
H
I
E
T
I
Y
E
-
N
I
L
--------
S
----
N
--
A
V
---
L
F
-----
K
Y
T
P
-
C
L
V
H
N
D
F
S
A
N
N
M
------
I
-
F
R
N
N
-----
R
L
F
G
V
I
-
D
F
----
G
D
F
N
V
G
D
P
-
D
N
D
F
L
C
-
L
-------------
L
D
C
S
--------------------
T
D
------
D
F
--
G
---------------
K
E
-----------
F
-----------
G
R
K
V
-
L
K
Y
Y
Q
-----
H
--
K
-------------------------------------------------------------------------------------------------------------------------
40
HHSearch
50.18
11%
-40
- C5 -
-
2QG7
-
?
D:
[112-399]
-------------------------------------------------------
E
F
Q
--
I
I
N
G
G
-
T
N
-
I
L
I
K
V
K
D
M
S
----------
K
Q
A
-
K
Y
L
I
R
-
L
Y
G
P
K
T
D
---------
N
R
E
R
E
K
K
I
S
C
I
-
L
Y
N
K
--
N
I
A
----
K
K
-
I
Y
V
F
F
T
N
-----------------
G
R
-----------
I
-
E
--------
E
F
M
D
G
Y
A
L
S
R
--
E
D
---------
I
-
K
N
----
P
----
K
F
---
Q
K
L
----
I
A
K
--
N
L
K
L
L
-
H
D
----
I
K
L
N
E
N
L
Y
K
E
-
L
Q
V
T
Q
K
V
P
G
T
-
R
P
S
-
F
L
W
N
T
-
I
-
W
-
K
-
Y
F
H
L
L
N
E
E
---------
R
KKICSFDAKA
N
I
L
K
--
L
I
--
D
------
F
D
V
L
R
D
S
I
V
-
E
V
E
--------
S
----
L
--
C
K
---
R
E
-----
N
S
P
I
-
V
L
C
H
C
D
L
L
S
S
N
I
------
I
-
N
T
V
G
-----
D
S
I
S
F
I
-
D
F
----
E
Y
S
C
P
M
E
R
-
A
Y
D
I
A
N
-
H
-------------
F
N
E
Y
-------------
A
------
G
F
NCDWDL
T
P
--
S
---------------
K
E
-----------
E
-----------
E
Y
H
F
-
I
M
H
Y
L
-----
G
--
T
D
------------------------------------------------------------------------------------------------------------------------
36
HHSearch
48.96
10%
-41
- C5 -
-
3MES
2
?
B:
[74-350]
-------------------------------------------------------
E
V
K
--
Q
I
F
S
G
L
T
N
-
Q
L
F
V
V
S
I
V
N
E
--------
L
K
H
P
-
R
I
L
F
R
-
I
Y
G
K
H
V
-------
F
-
Y
D
S
K
V
E
L
D
V
F
R
Y
-
L
S
N
I
--
N
I
A
----
P
N
-
I
I
A
D
F
P
-----------------
E
G
R
-----------
I
-
E
--------
E
F
I
D
G
E
P
L
T
T
-
K
-
Q
---------
L
-
Q
L
----
T
----
H
I
---
C
V
E
----
V
A
K
--
N
M
G
S
L
-
H
I
----
I
N
S
K
R
A
D
F
P
S
R
F
D
K
E
P
I
L
F
K
R
-
I
Y
--
L
W
R
E
E
-
A
K
I
-
Q
-
V
S
K
N
N
-
Q
I
---------
D
----------
K
E
L
Y
--
S
K
--
I
------
L
E
E
I
D
Q
L
E
E
-
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
--
L
Y
---
S
P
-----
A
F
S
L
-
V
F
A
H
N
D
L
Q
E
N
N
L
------
L
-
Q
T
Q
------
N
N
I
R
M
I
-
D
Y
----
E
Y
S
A
I
N
F
A
-
G
A
D
I
A
N
-
Y
-------------
F
C
E
Y
-------------
I
------
Y
D
------
Y
C
--
S
EKQPY
F
K
F
K
YEDYPC
E
E
-----------
L
-----------
R
K
L
F
-
I
S
V
Y
L
-----
S
--
Q
T
L
-----------------------------------------------------------------------------------------------------------------------
54
Fugue
48.70
10%
-70
- C5 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
----------------------
A
--
K
M
R
-
I
S
P
E
L
K
---
K
-
L
---
I
E
-
K
-----
Y
-
R
C
V
--
K
D
T
E
G
M
S
P
-
A
K
V
Y
K
L
V
G
E
N
----
E
---
N
L
Y
L
-
K
M
T
D
S
-
R
Y
K
G
T
--------
T
-
Y
D
V
E
R
E
K
D
M
M
L
W
-
L
E
G
K
-
L
P
V
-----
P
K
-
V
L
H
F
E
R
H
D
---------
G
--
W
S
N
L
L
M
-----------
S
-
E
--------
A
D
G
V
L
C
S
E
E
Y
-
E
D
E
---------
Q
-
S
P
----
E
----
K
I
---
I
E
L
----
Y
A
E
--
C
I
R
L
F
-
H
S
----
I
-----
D
I
S
D
-
C
P
Y
T
N
S
L
D
S
R
-
L
A
E
-
L
D
Y
L
L
-
N
N
D
-
L
-
A
D
V
D
C
E
N
W
---------
E
----------
E
D
T
P
--
F
K
--
D
------
P
R
E
L
Y
D
F
L
K
-
T
-------------------
E
---
K
P
-----
E
E
E
L
-
V
F
S
H
G
D
L
G
D
S
N
I
------
F
-
V
K
D
G
K
--
V
-
S
G
F
--
I
-
D
L
----
G
R
S
G
R
A
D
K
-
W
Y
D
I
A
F
-
C
-------------
V
R
S
I
-------------
R
------
E
D
------
I
G
--
E
---------------
E
Q
-----------
Y
-----------
V
E
L
F
-
F
D
L
L
G
-----
I
-----------------------------------------------
K
P
D
------------------
W
E
K
I
---
K
Y
Y
I
L
L
D
---------------
E
L
F
------------------------
42
SP3
48.67
9%
-21
- C5 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
---------------------------
G
-
S
P
A
A
W
V
---
E
-
R
---
L
F
-
G
-----
Y
-
D
W
A
--
Q
Q
T
I
G
C
S
D
A
A
V
F
R
L
S
A
Q
G
R
----
P
---
V
-----
L
F
V
K
-
T
D
L
S
G
A
L
N
E
--------
L
Q
D
E
A
A
R
L
S
W
-
L
A
T
T
--
G
V
P
---
C
A
A
-
V
L
D
V
V
T
-----------
E
--
A
G
R
D
W
L
-----------
L
-
L
--------
G
E
V
P
G
Q
D
L
L
S
-
S
H
L
---------
A
--
P
----
A
----
E
K
---
V
S
I
----
M
A
D
--
A
M
R
R
L
-
H
T
----
L
D
P
A
T
-----------
C
P
F
D
H
-
Q
A
K
-
H
R
I
E
R
-
A
R
T
-
R
-
M
E
A
G
L
V
D
Q
---------
D
----------
D
L
D
E
--
E
H
--
Q
------
G
L
A
P
A
E
L
F
A
-
R
L
K
--------
A
----
R
--
M
P
---
D
G
-----
E
D
-
L
-
V
V
T
H
G
D
A
C
L
P
N
I
------
M
-
V
--
E
N
--
G
-
R
F
S
G
F
I
-
D
C
----
G
R
L
G
V
A
D
R
-
Y
Q
D
I
A
L
-
A
-------------
T
R
D
--------------
I
------
A
E
------
E
L
--
G
---------------
G
E
-----------
W
-----------
A
D
R
F
-
L
V
L
Y
--------------
G
I
A
A
P
D
--
S
Q
R
-
I
A
F
-
Y
R
L
L
-
D
-
E
F
F
-------------------------------------------------------------------------------------------
27
HHSearch
48.30
15%
-14
- C5 -
-
2PPQ
-
KHSE_AGRFC
A:
[6-254]
--------------------
D
I
T
--
E
D
E
-
L
R
N
F
L
T
Q
--
Y
-
D
---
V
G
-
S
-----
L
T
S
Y
K
--
G
I
A
E
---
N
-
S
N
F
L
L
H
T
T
------------
K
D
-
P
L
I
L
T
-
L
Y
E
K
---------
K
-
N
D
L
P
F
F
L
G
L
M
Q
H
-
L
A
A
K
--
G
L
S
---
C
P
L
-
P
L
P
R
K
D
G
E
L
L
G
E
-----
L
--
S
G
R
P
A
A
-----------
L
-
I
--------
S
F
L
E
G
M
W
L
R
--------------
K
-
P
E
----
A
----
K
H
---
C
R
E
----
V
G
K
--
A
L
A
A
M
-
H
L
----
A
S
E
G
F
E
I
K
R
--
P
N
A
L
-
S
V
D
-------
G
W
K
V
------
L
-
W
D
K
S
E
E
R
A
--------------------
D
E
V
E
--
K
G
--
L
------
R
E
E
I
R
P
E
I
D
-
Y
L
A
--------
A
----
H
--
W
----
P
K
-----
D
L
P
A
-
G
V
I
H
A
D
L
F
Q
D
N
V
------
F
-
F
L
G
D
-----
E
L
S
G
L
I
-
D
F
----
Y
F
A
C
N
D
L
L
-
A
Y
D
V
S
I
-
C
-------------
L
N
A
W
-------------
C
------
F
E
KDG---
A
Y
--
N
---------------
V
T
-----------
K
-----------
G
K
A
L
-
L
E
G
Y
Q
-----
S
--
V
-------------------------------------------------------------------------------------------------------------------------
55
Fugue
47.85
15%
26
- C5 -
-
3DXP
1
?
A:
[20-359]
----------------
R
F
D
T
E
A
L
--
E
A
W
M
R
Q
H
V
E
G
---
F
-
A
---
G
P
-
L
-----
S
-
V
E
Q
--
F
K
G
Q
S
N
P
T
---
F
K
L
V
T
P
G
Q
----
T
---
Y
V
--------
M
R
A
K
P
G
A
I
E
R
E
Y
-
R
V
M
D
A
------------
L
A
G
-
T
D
V
P
---
V
A
K
M
Y
A
L
C
E
D
E
S
---------
V
--
I
G
R
A
F
Y
-----------
I
M
E
--------
F
V
S
G
R
V
L
W
D
Q
-
S
L
P
---------
G
M
S
P
----
A
----
E
R
---
T
A
I
----
Y
D
E
M
N
R
V
I
A
A
M
H
T
----
V
D
Y
Q
A
I
G
L
G
D
-
Y
G
K
P
G
-------------
N
Y
-
F
Q
R
-
Q
-
I
E
R
W
T
K
Q
Y
---------
K
----------
L
S
E
T
--
E
S
---------------
I
P
A
M
D
S
L
M
-------
D
----
W
--
L
P
---
Q
H
IPQED
A
D
L
T
-
S
I
V
H
G
D
Y
R
L
D
N
L
-------M
F
H
P
T
E
--
P
-
R
V
L
A
V
L
-
D
W
----
E
L
S
T
L
G
H
P
M
G
-
D
F
G
Y
-
H
C
MSWHIAPGQFRG
I
A
G
L
-------------
D
------
H
A
------
A
L
--
G
---------------
I
P
-----------
D
-----------
E
A
S
Y
-
R
K
L
Y
E
-----
Q
--
R
T
G
R
P
I
T
G
D
W
N
--
F
Y
L
-
A
F
S
M
F
R
I
A
-
G
-
I
L
Q
G
I
M
K
R
-
V
V
D
G
---
T
A
S
S
------------------
A
Q
A
L
---
D
A
G
K
R
A
R
P
M
A
E
M
G
W
E
Y
A
K
K
A
K
Q
---------------------------
64
Fugue
47.47
17%
5
- C2 -
-
5CXB
1
B:
[1-369]
----------------
P
S
P
D
E
L
K
--
P
F
-----------
P
-
T
---
V
Q
-
Q
-----
T
-
I
F
------
R
G
H
E
G
-
R
V
R
S
V
A
I
D
------------
P
T
-
G
V
A
L
A
-
T
G
G
D
D
G
T
V
R
V
W
E
L
L
-
T
G
R
Q
V
W
S
V
K
L
N
G
-
D
E
A
V
-
N
T
V
R
W
RP
T
K
D
-
T
F
I
L
A
A
A
A
---------
G
--
E
D
I
F
L
M
-----------
I
-
P
THPSVT--
P
A
L
D
Q
A
S
R
D
I
-
L
N
A
---------
G
-
F
P
----
P
----
G
K
---
W
A
R
----
P
G
T
--
R
L
E
D
--
E
G
----
V
L
L
R
I
T
V
R
S
T
-
I
K
A
I
S
W
H
R
R
G
-
D
H
F
-
A
T
V
S
P
-
S
G
Q
-
R
-
S
S
V
A
I
H
T
L
---------
S
----------
K
H
L
T
--
Q
I
--
P
------
F
R
K
L
N
G
L
A
Q
-
T
A
S
--------
F
----
H
--
P
L
----
R
-----
P
L
F
F
-
V
A
T
Q
R
S
I
R
C
Y
D
L
QKLELV
K
-
I
V
Q
P
G
--
A
-
K
W
I
S
S
F
-
D
V
H
PGG
D
N
L
V
V
G
S
Y
-
D
K
R
L
L
W
-
H
D------------
L
D
L
S
-------------
N
------
R
P
------
Y
K
--
T
---------------
M
R
-----------
F
-----------
H
T
E
A
-
I
R
A
V
R
F
HKGG
L
--
P
L
F
A
D
A
S
D
D
G
S
--
L
Q
I
-
F
H
G
-
K
V
P
N
-
D
-
Q
L
E
N
P
-
T
I
-
V
P
V
K
M
L
K
G
H
K
V
------------------
V
N
K
L
GVL
D
I
D
W
H
P
R
E
-
P
W
-
C
V
S
A
G
A
D
G
T
A
R
L
W
M-----------------------
28
HHSearch
46.94
14%
-20
- C5 -
-
3W0S
2
KHYB_ECOLX
A:
[6-237]
---------------------
L
T
--
A
T
S
-
V
E
K
F
L
I
E
K
F
D
-
S
---
V
S
-
D
--------
L
M
--
Q
L
S
E
G
E
E
S
-
R
A
F
S
F
D
V
G
------------
G
R
-
G
Y
V
L
R
-
V
N
S
C
A
D
----------
G
F
Y
K
D
R
Y
V
Y
R
H
-
F
A
S
A
--
A
L
P
---
I
P
E
-
V
L
D
I
G
E
F
S
------------
E
S
L
T
Y
C
-----------
I
-
S
--------
R
R
A
Q
G
V
T
L
Q
D
-
L
P
E
---------
T
-
E
L
----
P
----
A
V
---
L
Q
P
----
V
A
E
--
A
M
D
A
I
-
A
A
----
A
D
L
S
Q
T
S
G
---
F
G
P
F
G
P
Q
G
I
G
Q
Y
T
--
T
W
R
D
F
-
I
C
A
-
I
-
A
D
P
H
V
Y
H
W
---------
Q
----------
T
V
M
D
--
D
T
--
V
------
S
A
S
V
A
Q
A
L
D
-
E
L
M
--------
L
----
W
--
A
E
---
D
C
-----
P
E
V
R
-
H
L
V
H
A
D
F
G
S
N
N
V
------
L
-
T
D
N
G
-----
R
I
T
A
V
I
-
D
W
----
S
E
A
M
F
G
D
S
-
Q
Y
E
V
A
N
-
I
-------------
F
F
W
R
-------------
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
40.39
17%
0
- C5 -
-
6EF6
2
?
A:
[50-292]
---------------------------------------------------------------
N
L
S
E
N
-
A
T
Y
L
V
E
D
G
------------
E
H
-
Q
S
I
L
R
-
V
H
R
Q
D
Y
H
-----
Q
P
-
H
E
I
E
S
E
L
D
W
L
A
A
-
L
R
T
D
-
S
D
V
T
---
V
P
T
-
V
V
P
A
R
D
G
R
R
V
V
T
V
D
P
A
D---
V
P
R
H
V
V
-----------
H
-
F
--------
E
M
V
G
G
A
E
P
D
E
-
E
-----------
S
-
L
T
----
L
----
D
D
---
F
Q
T
----
L
G
R
--
I
T
A
S
L
-
H
E
----
H
S
Q
R
W
T
R
P
A
----
G
F
G
R
F
S
W
D
-
W
E
H
-
C
L
-
G
D
-
T
-
P
-
R
-
W
G
R
W
Q
D
A
E
---------
G
------------
V
G
--
A
S
--
E
------
T
A
L
L
T
R
A
Q
D
-
L
L
H
--------
R
----
K
--
L
E
E
Y
G
S
G
-----
P
D
R
Y
-
G
L
I
H
A
D
L
R
L
A
N
L
------
L
-
V
D
S
S
T
--
P
Q
R
T
I
T
V
I
-
D
F
----
D
D
C
G
F
G
W
Y
-
F
Y
D
F
G
T
-
A
-------------
V
S
F
I
-------------
E
------
H
D
------
P
R
--
L
---------------
G
E
-----------
W
-----------
Q
E
S
W
-
V
A
G
Y
R
-----
S
--
R
-------------------------------------------------------------------------------------------------------------------------