@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : D1YUH5_METPS: (2019-01-27 )
MQATLDWLAGLARQHPEVFGGHPGEMAVLEASRSSSHESRVYGSGGALVHVKFFRRTLGRTSVTYDPCREMKAEYDTLREFEKNGFASGRHRVVRTLGINESLDCALATAYVPGDTLLSIIQRTLKGGDDGELLEALGLAAGFLRKVHGLMPQSPKVDAAETFYSYMKPLFYLEEQGALDGFHRRVTKGLSRWYGHRPLFEQRGVTVHGDANPSNFKIHEGVIYGLDLERSRPGRSPLLDVGTMVAELEHHCAYVAGDAGRAKPYVERFLRAYAPSPADRKKIDELLPFYVSRGLLKIAMLGYWKHGYRRSLVEAGARRIEEGP
Atome Classification :
(21 SA)
----------------------------------------------------...----....-..10........20........30.....-...40----...---.-....50-----....------------....----60....--------------.-...--70...------....-.80-..-.-.....90........100-------..------.-.....110---..---.-.-..-----..120.....-..130-----..---------.......140.-....--.-------------.150---...----...-.--------.------.----------160.....-----..---------170------..----------..-.--..--.---------180-------..-...-----...-.190...---------..---...200.--......210.....-------------.--.220---....-.-.------..230----......--..240--......---------.250......-------.260--..-------.-.....----.270.---------.--..------...280.......290.......--300....-------...310----.........320..-------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------------------------MQ
A
----
T
L
D
W
-
L
A
G
L
A
R
QH
P
E
VFGGHPG
E
M
A
V
L
EASRSSS-HES
R
V
----YGS---G-
G
A
L
V
H
V
-----
K
F
F
R
------------
R
TLG----RTSV
T
Y
--------------
D
-
P
C
R
--
E
M
K
A
E
------
Y
D
T
L
-
R
E
F
-
E
K-N-GFASGR
H
R
V
V
R
T
LGINE--------SL------D-
C
A
L
A
T
AY----VP---
G
-
D
-
T
L
-----
L
S
I
I
Q
R
T
LKG-GD
D
-------
G
E
---------
L
L
E
A
L
G
L
A
A
G
F
-
L
R
K
V
--
H
-------------
G
L-----MPQ----SPK-V--------
D
------
A
----------
A
E
T
F
Y
S
Y
M
-----
K
P
---------
L
F
-------
Y
L
----------EE-Q--GA--L---------
D
---------
G
F
-
H
R
R
-----
V
T
K
-
G
L
-
S
R
W
Y---------GH---R
P
L
F
E
QR--
G
V
T
V
HGDANPS
N
F
K
-------------
I
--HE-
G
---
V
I
Y
G
-
L
-D------LERS-----RPGRS
P
--
L
L
D
V
G
--
T
M
V
A
E
L
---------
E
H
H
C
AYVAGD-------AG----RA-------
K
-
P
Y
V
E
R
----
F
L
R
AY---------A--PS------P
A
D
R
K
K
I
D
E
L
L
P
F
Y
V
S
R
G
L
L
K
I
A
--
M
L
G
Y
W
K
H
-------
G
Y
R
R
------
S
L
V
E
A
G
A
R
RIEEGP-------------------------------------------
31
SP3
75.29
15%
-21
- C5 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
------------------------------------------------------------------
G
S
P
A
A
W
V
E
R
L
F
G
Y
--
D
W
A
Q
Q
T
I
G
C
S
D
A
-
A
V
F
R
L
----
S
A
Q
---
G
-
R
P
V
L
F
V
-----
K
T
-----------------
D
----
L
S
G
A
L
N
--------------
E
-------
L
Q
D
E
------
A
A
R
L
-
S
W
L
-
A
T
-
T
-
G
V
P
-----
C
A
A
V
L
D
V
V
T
--------
E
A
------
G
R
D
W
L
L
L
G
E
----
V
P
---
G
-
Q
-
D
L
--------------
L
-
S
S
H
-------
L
A
---------
P
A
E
K
V
S
I
M
A
D
A
-
M
R
R
L
--
H
-------------
T
L
-----
D
P
A
----
T
C
P
-
F
--------
D
------
H
------------
Q
A
K
H
R
I
-----
E
R
---------
A
R
-------
T
R
----------
M
E
-
A
--
G
L
--
V
---------
D
QD-------
D
L
-
D
E
E
HQGLA
P
A
E
-
L
F
-
A
R
L
K
---------
A
R
---
M
P
-
D
G
E
D
--
L
V
V
T
H
G
D
A
C
L
P
N
I
M
-------------
V
--
E
N
-
G
---
R
F
S
G
-
F
I
D
------
C
G
R
L
-----
G
V
A
-
D
R
--
Y
Q
D
I
A
--
L
A
T
R
D
I
---------
A
E
E
L
--------------------
G
-------
G
-
E
W
A
D
R
----
F
L
V
L
Y
GIA------
A
--
P
D
------
S
Q
R
I
A
F
Y
R
L
L
D
E
F
F
--------------------------------------------------------------------------------------------
41
Fugue
75.27
12%
-16
* C5 *
-
3HAM
3
?
A:
[1-299]
-----------------------------------------------------------
M
V
N
L
-
D
A
E
I
Y
E
H
L
N
K
Q
I
K
I
N
E
------
L
R
Y
L
S
S
G
-
D
D
S
D
T
----
F
L
C
---
N
-
E
--------------------------
Q
Y
V
V
----
K
V
P
K
R
D
--------------
S
-
V
R
I
--
S
Q
K
R
E
------
F
E
L
Y
-
R
F
L
-
E
N
-
C
-
K
L
S
Y
Q
I
P
A
V
V
Y
-----
Q
--------
S
D
------
R
-
F
N
I
M
K
-
Y
----
I
K
---
G
-
E
-
R
I
-----
T
---
Y
E
Q
Y
H
K
-
L
S
E
-------
K
E
---------
K
D
A
L
A
Y
D
E
A
T
F
-
L
K
E
L
--
H
-------------
S
I
-----
E
I
D
----
C
S
V
-
S
--------
L
------
F
----------
S
D
A
L
V
N
K
K
-----
D
K
---------
F
L
-------
Q
D
----------
K
K
-
L
--
L
I
--
S
I
L
E
K
E
QLLT
D
---------
E
M
-
L
E
H
-----
I
E
T
-
I
Y
-
E
N
I
L
---------
N
N
---
A
V
L
F
K
Y
T
--
P
C
L
V
H
N
D
F
S
A
N
N
M
I
-------------
F
--
R
N
-
N
---
R
L
F
G
-
V
-
I
------------------
D
F
G
--
D
F
N
V
G
--
D
P
D
N
D
F
---------
L
C
L
L
D
C
S
T
D
D
-------
F
G
------------------
K
E
----
F
G
R
K
V
---------
L
--
K
Y
------
Y
Q
H
K
A
P
E
V
A
E
R
K
A
E
L
N
D
V
Y
W
S
I
D
--
Q
I
I
Y
G
Y
E
-------
R
K
D
R
------
E
M
L
I
K
G
V
S
E
L
L
Q
T
Q
AEMFIF-------------------------------------
49
Fugue
74.84
20%
12
- C5 -
-
4O7O
-
MAK1_MYCTU
A:
[6-454]
TLATKLP
W
S
D
W
L
S
R
QRWYAGRNRELATVKPG
V
V
V
A
LRHN
L
D
L
V
L
V
D
V
T
Y
TDG
A
T
E
----
R
Y
Q
V
-
L
V
G
W
D
K
A
A
I
G
V
A
D
D
R
T
G
F
D
A
L
Y
D
V
A
G
P
Q
F
-
L
L
S
L
I
----
V
S
S
AVC
G
-
T
S
T
G
E
V
-----
T
F
T
R
E
P
D
V
E
L
P
F
AAQP
R
V
C
D
A
EQ
S
N
T
S
V
I
F
--------------
D
-
R
R
A
--
I
L
K
V
F
R
RVSSG
I
N
P
D
-
I
E
L
-
N
R
-
V
-
L
T
R
A
G
N
P
H
V
A
R
L
L
G
A
Y
Q
F
GDAL---
A
Y
------
A
-
L
G
M
V
T
E
Y
EANA
A
E
---
G
-
W
-
A
M
-----
A
T
A
S
V
R
D
L
F
A
-
E
G
D
LYAHEVG
G
D
---------
F
A
G
E
S
Y
R
L
G
E
A
-
V
A
S
V
--
H
-------------
A
T
-----
L
A
D
----
S
L
G
-
T
--------
A
------
Q
----------
A
T
F
P
V
D
R
M
-----
L
A
---------
R
L
-------
S
S
----------
T
V
-
A
V
V
P
E
--
L
---------
R
---------
E
Y
-
A
P
T
-----
I
E
Q
-
Q
F
-
Q
K
L
----------
A
A
---
E
A
I
T
V
Q
R
-----
V
H
G
D
L
H
L
G
Q
V
L
-------------
R
T
P
E
S
-
W
---
L
L
I
D
-
F
-
E
GEPGQP
L
D
E
R
-----
R
A
P
D
S
P
--
L
R
D
V
A
--
G
V
L
R
S
F
---------
E
Y
A
A
Y
G
P
L
V
D
QATDK
Q
L
A
A
----
R
A
-------
R
-
E
W
V
E
R
N
R
A
A
F
C
D
G
Y
---------
A
--
V
A
S
G----
I
D
P
R
D
S
A
L
L
L
G
A
Y
E
L
D
K
A
V
Y
E
T
G
--
Y
E
T
R
H
R
P
-------
G
W
L
P
------
I
P
L
R
S
I
A
R
L
T
A
----------------------------------------------
20
HHSearch
73.63
18%
3
- C5 -
-
3F7W
7
?
A:
[25-286]
-------------------------------------------------------------------------------------------
H
S
-
H
R
W
H
L
----
Y
R
V
E
L
A
D
-
G
T
P
L
F
V
-----
K
A
L
P
------------
D
D
A
P
----
A
---------------------
L
D
G
--
L
F
R
A
E
------
A
L
G
L
-
D
W
L
-
G
R
-
S
-
F
----
G
S
P
V
P
Q
V
A
G
W
D
D
------------------
R
T
L
A
M
E
W
----
V
D
---
E
-
R
-
P
P
-----
T
P
--------------------------------
E
A
A
E
R
F
G
H
Q
-
L
A
A
M
--
H
-------------
L
A
-----
G
A
E
----
S
F
G
-
A
--------
T
------
W
D
G
Y
IGP
L
P
M
D
N
T
P
R
S
T
W
P
-----
E
F
Y
A
E
QRI
L
P
Y
L
R
-------
R
A
----------
A
D
-
R
--
G
A
--
L
---------
T
---------
P
G
-
D
V
R
-----
L
V
E
-
K
V
-
L
D
A
L
---------
D
H
---
L
A
G
D
P
E
P
--
P
A
R
I
H
G
D
L
W
N
G
N
V
L
-------------
W
--
Q
D
-
D
---
G
A
V
V
-
I
-
D
------
P
A
-
A
-----
H
G
G
-
H
R
--
E
A
D
L
A
--
M
L
A
L
F
G
-----------------------------------------
L
-
P
Y
L
D
R
----
V
R
D
A
Y
---------
N
--
E
V
------
A
P
L
A
E
G
W
R
A
R
I
P
L
H
Q
L
H
P
L
L
V
H
V
--
C
--
L
F
G
A
-------
A
Y
R
T
------
T
L
V
D
T
A
R
A
A
L
-----------------------------------------------
45
Fugue
73.19
13%
-6
- C5 -
-
2QG7
-
?
A:
[50-458]
------------------YPITESNLRILEGED
R
S
E
K
A
K
E
L
L
K
K
Y
VSNVFEN
E
K
T
----
L
Y
I
Y
-
C
K
Y
V
M
L
H
Y
G
K
D
L
V
N
P
N
E
V
D
S
L
E
F
Q
I
I
N
---
G
T
N
I
L
----
I
K
V
---
K
-
D
M
S
K
Q
A
-----
K
Y
L
I
------------
R
L
Y
G
----
P
T
D
E
I
I
--------------
N
-------
R
E
R
E
------
K
K
I
S
-
C
I
L
-
Y
N
-
K
-
N
I
A
K
K
I
Y
V
F
F
T
N
G
R
I
E
E
--------
F
M
------
D
G
Y
A
L
S
R
E
D
----
I
K
---
N
-
P
-
K
F
-----
Q
K
L
I
A
K
N
L
K
L
-
L
H
D
-------
I
K
---------
L
N
E
N
L
Y
K
E
L
Q
V
-
T
Q
K
V
--
P
-------------
G
------
T
R
P
----
S
F
L
-
W
--------
N
------
T
----------
I
W
K
Y
F
H
L
L
-----
N
E
---------
E
R
K
KICSF-
D
A
----------
K
A
-
N
--
I
L
--
K
---------
L
---------
I
D
-
F
D
V
-----
L
R
D
-
S
I
-
V
E
V
E
---------
S
L
---
C
K
R
E
N
S
P
--
I
V
L
C
H
C
D
L
L
S
S
N
I
I
-------------
N
--
T
V
-
G
E
G
D
S
I
S
F
-
I
-
D
------
F
E
Y
S
-----
C
P
M
E
-
R
--
A
Y
D
I
A
--
N
H
F
N
E
Y
---------
A
G
F
--
N
C
D
W
D
-------
L
T
----
P
S
-------
K
-
E
E
E
Y
H
----
F
I
M
H
Y
---------
L
GT
D
D
------
E
E
L
I
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
--
L
W
S
L
L
Q
G
-------
M
H
S
F
------
D
F
I
N
Y
G
M
T
R
L
T
A
S
C
L
P
I
F
R
S
K
V-----------------------------------
36
SP3
71.52
12%
-4
- C5 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-------------------------------G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
----
A
H
M
L
-
C
A
R
F
L
G
--
G
A
W
K
T
V
P
L
E
H
L
R
I
S
R
I
K
G
G
M
S
-
N
M
L
F
L
----
C
R
L
---
S
-
E
V
Y
P
P
I
RNEPN
K
V
L
L
------------
R
V
Y
F
----
N
P
E
T
-------------------
E
S
--
H
L
V
A
E
------
S
V
I
F
-
T
L
L
-
S
E
-
R
-
H
L
G
------
P
K
L
Y
G
I
F
S
--------
G
----------
G
R
L
E
E
Y
----
I
P
---
S
---------------
R
P
L
S
C
-
H
E
I
-------
S
L
----------
A
H
M
S
T
K
I
A
K
R
-
V
A
K
V
--
H
-------------
Q
L
E----
V
P
I
----
W
K
E
-
P
--------
D
Y
-----
L
----------
C
E
A
L
Q
R
W
L
-----
K
Q
---------
L
T
-------
G
T
V
DAE
H
R
F
D
L
P
E
E
-
C
--
G
V
--
S
---------
S
---------
V
N
-
C
L
D
-----
L
A
R
-
E
L
-
E
F
L
R
---------
A
H
---
I
S
L
S
K
S
P
--
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
-------------
L
--
P
K
-
R
---
L
V
L
--
I
-
D
------
F
E
Y
A
-----
S
Y
N
-
Y
R
--
A
F
D
F
A
--
N
H
F
I
E
W
---------
T
I
D
Y
D
I
D
E
A
P
-------
F
Y
----
K
I
Q
TENFPE
N
-
D
Q
M
L
E
----
F
F
L
N
Y
L
R
E
Q
GNTRE
N
--
E
L
------
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
--
V
W
G
L
L
Q
V
ELSPVGF
G
F
A
D
------
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA-------------------------------------
42
Fugue
63.02
11%
-19
- C5 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
----------------------------------------------------
T
D
I
----
T
E
D
E
-
L
R
N
F
L
T
Q
Y
--------
D
V
G
S
L
T
S
Y
K
G
I
A
E
-
N
S
N
F
L
----
L
H
T
---
T
-
K
D
P
L
I
L
-----
T
L
Y
E
------------
K
-------------------------------
K
--
N
D
L
P
F
------
F
L
G
L
M
Q
H
L
-
A
A
-
K
-
G
L
S
C
P
L
P
L
P
R
K
D
G
E
L
L
G
--------
E
L
------
S
-
G
R
P
A
A
L
I
S
F
--
L
E
---
G
M
W
-
L
R
----------------
K
P
E
-------
A
K
---------
H
C
R
E
V
G
K
A
L
A
A
M
H
L
A
S
--
E
-------------
G
F
-----
E
I
K
----
R
P
N
-
A
--------
L
------
S
----------
V
D
G
W
K
V
L
W
-----
D
K
---------
S
E
-------
E
R
----------
A
D
-
E
---
V
--
E
---------
K
---------
G
L
-
R
E
E
-----
I
R
P
-
E
I
-
D
Y
L
A
---------
A
H
---
W
P
K
D
L
P
A
--
G
-
V
I
H
A
D
L
F
Q
D
N
V
F
-------------
F
--
L
G
-
D
---
E
L
S
G
-
L
-
I
------
D
F
Y
F
-----
A
C
N
D
L
L
--
A
Y
D
V
S
--
I
C
L
N
A
W
--------------
C
F
E
K
D
-------
G
A
----
Y
N
-------
V
-
T
K
G
K
A
----
L
L
E
G
Y
---------
Q
--
S
V
------
R
P
L
S
E
A
E
L
E
A
L
P
L
L
S
R
G
S
A
L
R
F
F
--
L
T
R
L
Y
D
W
-------
L
T
T
P
------
A
G
A
L
V
V
K
K
D
P
L
E
Y
L
R
K
L
R
F
H
R
T
IANVAEYGLA-------------------------
29
HHSearch
62.65
17%
-24
- C5 -
-
4DCA
1
?
A:
[41-270]
-----------------------------------------------------------------------------------
E
L
R
Y
L
S
--
S
G
-
D
D
S
D
T
----
F
L
C
-----
N
E
Q
Y
V
V
-----
K
V
P
K
------------
R
D
S
---------------------------
V
R
I
--
S
Q
K
R
E
------
L
E
L
Y
-
R
F
L
-
E
N
-
C
-
K
L
---
S
Y
Q
I
P
A
V
V
Y
Q
S
-----------------
D
-
R
F
N
I
M
K
Y
----
I
K
---
G
-
E
-
R
I
-----
T
Y
E
Q
Y
H
K
L
----
S
E
-------
K
E
---------
K
D
A
L
A
Y
D
E
A
T
F
-
L
K
E
L
--
H
-------------
S
I
-----
E
I
D
----
C
S
V
-
S
--------
L
F
-----
S
----------
D
A
L
V
N
K
K
D
-----
K
F
---------
L
Q
D
K
K
L
L
I
S
I
L
----------
E
K
-
E
--
Q
L
--
L
---------
T
---------
D
E
-
M
L
E
-----
H
I
E
-
T
I
Y
E
N
I
L
---------
S
N
---
A
V
L
F
K
Y
T
--
P
C
L
V
H
N
D
F
S
A
N
N
M
I
-------------
F
--
R
N
-
N
R--
L
F
G
V
-
I
-
D
------
F
G
D
F
-----
N
V
G
-
D
P
--
D
N
D
F
L
--
C
L
L
D
C
S
---------
T
D
----------------
D
----
F
G
-------
K
-
E
F
G
R
K
----
V
L
K
Y
Y
---------
Q
--
H
K
----------------------------------------------------------------------------------------------------------------
55
Fugue
61.79
12%
29
- C5 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
-----------------------------------------------SAFT
F
Q
T
L
----
H
P
D
T
-
I
M
D
A
L
F
E
H
-----
G
I
R
V
D
S
G
L
T
P
L
N
S
Y
E
N
-
R
V
Y
Q
F
----
Q
D
E
---
D
-
R
R
R
F
V
V
-----
K
F
Y
R
------------
P
--
E
----
R
W
T
--------------------
A
D
--
Q
I
L
E
E
------
H
Q
F
A
-
L
Q
L
-
V
N
-
D
-
E
-----------
V
P
V
A
A
--------
P
V
------
A
-
F
N
G
Q
T
L
L
----
N
H
---
Q
-
G
-
F
Y
-----
F
A
V
F
P
S
V
G
G
R
-
Q
F
E
-------
A
D
---------
N
I
D
Q
M
E
A
V
G
R
Y
-
L
G
R
M
--
H
-------------
Q
T
G
R
KQL
F
I
H
----
R
P
T
-
I
--------
G
------
L
----------
N
E
Y
L
I
E
P
R
-----
K
L
---------
F
E
-------
D
A
----------
T
L
I
P
--
S
G
--
L
---------
K
---------
A
A
-
F
L
K
-----
A
T
D
-
E
L
-
I
A
A
V
---------
T
A
---
H
W
R
E
D
F
T
--
V
L
R
L
H
G
D
C
H
A
G
N
I
L
-------------
W
--
R
D
-
G
---
P
M
F
--
V
-
D
------
L
D
D
A
-----
R
----------
N
G
--
P
A
V
Q
D
L
---------
W
---
M
L
L
N
G
D
-------
K
A
----
E
Q
-------
R
-
M
Q
L
E
T
----
I
I
E
A
Y
---------
E
--
E
F
------
S
E
F
D
T
A
E
I
G
L
I
E
P
L
--
R
A
M
R
L
V
Y
--
Y
L
A
W
L
M
R
-------
R
W
A
D
------
P
A
F
P
K
N
F
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
EPPLQLTPMY----------------
47
Fugue
60.11
10%
5
- C5 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
------------------------------------------------------
T
----
L
P
A
V
-
I
S
R
W
L
S
S
V
L
P
G
G
A
A
P
E
V
T
V
E
S
G
V
D
S
T
G
M
S
-
S
E
T
I
I
L
T
A
R
W
Q
Q
---
D
-
G
R
S
I
Q
Q
-----
K
L
V
A
------------
R
V
A
P
----
A
A
E
D
V
P
--------------
V
F
P
T
Y
--
R
L
D
H
Q
------
F
E
V
I
-
R
L
V
-
G
E
-
L
-
T
D
V
P
V
P
R
V
R
W
I
E
T
T
G
D
V
--------
L
G
------
T
-
P
F
F
L
M
D
Y
----
V
E
---
G
-
V
-
V
P
PDVMP
Y
T
F
G
D
N
W
F
A
D
-
A
P
A
-------
E
R
---------
Q
R
Q
L
Q
D
A
T
V
A
A
-
L
A
T
L
--
H
-------------
S
I
-----
P
N
A
----
Q
N
T
-
F
--------
S
------
F
----------
L
T
D
T
T
L
H
R
-----
H
F
---------
N
W
-------
V
R
----------
S
W
-
Y
--
D
F
--
A
---------
V
---------
E
G
-
I
G
R
S
P
---
L
L
E
-
R
T
-
F
E
W
L
---------
Q
S
H
WP
D
D
A
A
A
R
E
--
P
V
L
L
W
G
D
A
R
V
G
N
V
L
-------------
Y
--
R
D
-
F
---
Q
P
V
A
V
L
-
D
------
W
E
M
V
-----
A
L
G
-
P
R
--
E
L
D
V
A
W
M
I
F
A
H
R
V
---------
F
Q
E
L
A
G
L
A
T
L
-------
P
G
----
L
P
-------
E
V
M
R
E
D
D
----
V
R
A
T
Y
---------
Q
--
A
L
------
T
--
G
V
E
L
G
D
L
-
H
W
F
Y
V
Y
S
G
V
M
W
A
C
V
F
M
R
T
G
A
R
-------
R
V
H
F
------
G
E
I
E
K
P
D
D
V
E
S
L
F
Y
H
A
G
L
M
K
H
L
L
G
EEH------------------------------
32
SP3
58.54
15%
59
- C5 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
--------------------------------------------------AK
M
R
I
----
S
-----
P
E
L
K
K
----
L
I
E
K
Y
--
R
C
V
K
D
T
E
G
M
S
P
A
-
K
V
Y
K
L
----
V
G
E
---
N
-
E
N
L
Y
L
K
-----
M
T
D
S
------------
R
Y
K
G
-------
T
T
Y
--------------
D
-------
V
E
R
E
------
K
D
M
M
-
L
W
L
-
E
G
---
K
L
P
V
P
K
---
V
L
H
F
E
R
H
D
--------
G
-------
W
-
S
N
L
L
M
S
E
----
A
D
---
G
-
V
-
L
-----------
C
S
E
E
Y
-
E
D
E
-------
Q
S
---------
P
E
K
I
I
E
L
Y
A
E
C
-
I
R
L
F
--
H
-------------
S
I
-----
D
I
S
----
D
C
P
-
Y
--------
T
------
N
------------
S
L
D
S
R
L
-----
A
E
---------
L
D
-------
Y
L
----------
L
N
-
N
--
D
L
--
A
---------
D
VDCENWEED
T
P
-
F
K
D
-----
P
R
E
-
L
Y
-
D
F
L
K
---------
T
E
---
K
P
--
E
E
E
--
L
V
F
S
H
G
D
L
G
D
S
N
I
F
-------------
V
--
K
D
-
G
---
K
V
S
G
-
F
I
D
------
L
G
R
S
-----
G
R
A
-
D
K
--
W
Y
D
I
A
--
F
C
V
R
S
I
---------
R
E
D
---------------
I
----
G
E
-------
E
-
Q
Y
V
E
L
----
F
F
D
L
L
GI-------
K
--
P
D
------
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
--------------------------------------------------------------------------------------------
53
Fugue
56.99
16%
-41
- C1 -
-
4GC0
5
XYLE_ECOLI
A:
[5-479]
-------------------YNS
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
VISGT
V
E
S
L
N
T
----
V
F
V
A
-
P
Q
N
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
-
L
G
G
Y
C
----
S
N
R
---
F
-
G
R
R
D
S
L
-----
K
I
A
A
------------
V
L
F
F
----
I
S
G
V
G
S
A
WPELGFTSINPDN
T
-
V
P
V
--
Y
L
A
G
Y
------
V
P
E
F
-
V
I
Y
R
I
I
-
G
-
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
APAHI
R
G
K
L
------
V
-
S
F
N
Q
F
A
I
----
I
F
---
G
-
Q
-
L
L
-----
V
Y
C
V
N
Y
F
I
A
R
-
S
G
D
-------
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
-
F
L
M
L
--
L
-------------
Y
T
-----
V
P
E
----
S
P
R
-
W
L
M
S
R
GK
Q
E
Q
------
A
----------
E
G
I
L
R
K
I
M
-----
G
N
---------
T
L
-------
A
T
----------
Q
A
-
V
--
Q
E
--
I
---------
K
---------
H
S
-
L
D
H
-----
G
R
K
-
T
G
-
G
R
L
L
M
F
GVG
V
I
V
I
G
V
---
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
GAS
T
D
I
A
L
L
Q
T
I
--
I
V
-
G
---
V
I
N
L
-
T
-
F
------
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
--
L
Q
I
I
G
--
A
L
G
M
A
I
---------
G
M
F
S
L
G
T
A
F
Y
-------
T
Q
AP
G
I
V
A
-------
L
-
L
S
M
L
F
----
Y
V
A
A
F
---------
A
--
M
S
WG----
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
--
V
A
A
Q
W
L
A
-------
N
Y
F
V
------
S
W
T
F
P
M
M
D
K
N
S
W
L
V
A
H
FHNG
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
KFVPETKGKTLEELEALWE
44
Fugue
56.14
14%
6
- C5 -
-
3JR1
3
?
A:
[14-309]
-----------------------------------------------------
N
L
----
Y
F
Q
G
M
W
K
S
I
S
Q
V
L
A
E
Q
F
G
-
A
Y
Y
F
I
K
H
K
E
K
L
Y
S
G
E
M
N
E
I
W
L
----
I
N
D
---
E
-
V
Q
T
V
F
V
-----
K
I
N
E
------------
R
S
Y
R
----
S
M
--------------------------
F
R
A
E
------
A
D
Q
L
-
A
L
L
-
A
K
-
T
-
N
S
I
----
N
V
P
L
V
Y
G
I
G
N
--------
S
-------------------------
Q
-
G
-
H
S
-----
F
L
L
L
E
A
L
N
K
S
-
K
N
K
-------
Q
S
---------
S
F
T
I
F
A
E
K
I
A
Q
-
L
H
Q
I
--
Q
GPDKYGLD
F
D
T
W
L
G
P
-----
I
Y
Q
P
N
D
W
Q
T
S
-
W
--------
A
------
K
----------
F
F
S
E
N
R
I
G
-----
W
Q
---------
L
Q
-------
I
C
----------
K
E
-
K
--
G
L
--
I
---------
F
---------
G
N
-
I
D
L
-----
I
V
Q
-
I
V
-
A
D
T
L
---------
S
K
------
H
N
P
K
--
P
S
I
L
H
G
N
L
W
I
E
N
C
I
-------------
Q
--
V
D
-
D
-----------------------------
K
I
F
--
V
C
N
P
A
--
C
Y
W
G
D
R
---------
E
C
D
I
A
F
S
S
L
F
-------
E
P
----
F
P
-------
T
-
N
F
Y
Q
R
----
Y
N
E
I
Y
------------
P
L
------
E
E
G
Y
L
E
R
K
L
I
Y
Q
L
Y
--
Y
L
L
N
F
S
Y
--
R
Y
Y
N
K
K
Q
-------
S
Y
V
S
------
L
T
Q
K
L
I
N
Q
I
L
H
K
---------------------------------------------
5
HHSearch
56.01
15%
-18
- C5 -
-
5UXD
2
?
A:
[25-251]
-----------------------------------------------------------------------------------
T
L
R
T
E
E
--
I
G
-
L
D
F
R
V
----
A
F
A
R
A
H
D
-
G
G
D
W
V
L
-----
R
L
P
R
------------
R
P
D
---------------------------
V
L
E
--
R
A
A
V
E
------
G
R
L
L
-
A
M
L
-
A
P
H
L
-
D
-----
V
A
V
P
D
W
R
I
S
T
-----------------
S
-
E
L
I
A
Y
P
L
----
L
P
---
G
-
S
-
P
G
-----
L
T
V
A
A
D
G
E
V
S
W
H
V
D
-------
M
A
---------
S
T
V
Y
A
R
S
L
G
S
V
-
V
A
Q
L
--
H
-------------
A
V
-----
D
A
E
----
A
A
A
A
T
--------
G
I
E
V
R
S
-
P
----------
A
Q
V
R
G
A
W
R
-----
Q
D
---------
L
A
-------
R
V
----------
G
A
-
E
--
F
E
--
I
---------
A
---------
P
A
-
L
R
--------
E
-
R
W
-
E
A
W
L
---------
A
D
---
D
G
C
W
P
G
H
--
S
V
L
T
H
G
E
L
Y
P
A
H
T
L
-------------
V
--
E
D
-
E
R--
I
T
A
V
-
L
-
D
------
W
T
T
A
-----
A
V
G
-
D
P
--
A
K
D
L
M
--
F
H
Q
V
S
A
---------
P
-------------------------------
S
-
A
I
F
E
V
----
A
L
Q
A
Y
---------
A
--
E
G
----------------------------------------------------------------------------------------------------------------
7
HHSearch
55.75
18%
1
- C5 -
-
3DXQ
-
?
B:
[27-232]
-------------------------------------------------------------------------------------------
G
G
-
L
T
N
L
V
----
F
R
A
------
G
D
L
C
L
-----
R
I
P
------------------------------------------------
N
R
A
N
E
------
A
V
A
A
-
R
E
A
-
A
K
-
A
-
G
-----
V
S
-
P
E
V
L
H
V
D
P
--------
A
-------
T
-
G
V
M
V
T
R
Y
----
I
A
---
G
-
A
Q
T
M
-----
S
P
E
K
F
K
----------------
T
---------
R
P
G
S
P
A
R
A
G
E
A
-
F
R
K
L
--
H
-------------
G
S
-----
G
A
V
----
F
P
F
-----------------
R
----------
F
E
L
F
A
M
I
D
-----
D
Y
---------
L
K
-------
V
L
----------
S
T
-
K
--
N
V
--
T
---------
L
---------
P
A
-
G
Y
H
-----
D
V
V
R
E
A
-
G
G
V
R
---------
S
A
---
L
A
A
H
P
L
P
--
L
A
A
C
H
C
D
P
L
C
E
N
F
L
-------------
D
--
T
G
-
E
---
R
M
W
I
-
V
-
D
------
W
E
Y
S
-----
G
M
N
-
D
P
--
L
W
D
L
G
--
D
L
S
V
E
G
---------
K
F
----------------------
N
-------
A
-
N
Q
D
E
E
----
L
M
R
A
Y
---------
F
--
G
G
----------------------------------------------------------------------------------------------------------------
54
Fugue
55.35
12%
9
- C5 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
--------------------------------------G
M
K
E
L
L
S
T
MDLDTD
A
N
T
----
I
P
E
L
-
K
E
R
A
H
M
L
C
A
R
F
L
G
G
A
W
K
T
V
P
L
E
H
L
R
I
S
R
I
-
K
G
G
M
S
----
N
M
L
---
F
-
L
C
R
L
S
E
-----
V
Y
P
P
------------
I
R
N
E
----
P
N
K
V
L
L
--------------
R
-
V
Y
F
--
N
P
E
T
E
------
S
H
L
V
-
A
E
S
-
V
I
-
F
-
T
L
L
S
E
R
H
L
G
P
K
L
Y
G
I
F
S
--------
G
----------
G
R
L
E
E
Y
----
I
P
---
S
-
R
-
P
L
S
C
---
H
E
I
S
L
A
H
M
S
T
-
K
I
A
-------
K
R
---------
V
A
K
V
H
Q
L
E
V
P
I
-
W
K
E
P
--
D
-------------
Y
L
-----
C
E
A
----
L
Q
R
-
W
--------
L
------
K
----------
Q
L
T
G
T
V
D
A
-----
E
H
---------
R
F
-------
D
L
----------
P
E
-
E
--
C
G
--
V
---------
S
---------
S
V
N
C
L
D
-----
L
A
R
-
E
L
-
E
F
L
R
---------
A
H
---
I
S
L
S
K
S
P
--
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
-------------
L
--
P
K
-
R
---
L
V
L
--
I
-
D
------
F
E
Y
A
-----
S
Y
N
Y
-
R
--
A
F
D
F
A
--
N
H
F
I
E
W
T
IDYDID--
E
A
P
F
Y
K
I
Q
T
E
-------
N
F
----
P
E
-------
N
-
D
Q
M
L
E
----
F
F
L
N
Y
---------
L
--
R
E
Q
GNTRE
N
E
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
--
F
W
G
V
W
G
L
-------
L
Q
V
E
LSPVGF
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA---------------------------------
48
Fugue
54.33
11%
6
- C5 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
------------------------------------------------------
K
----
T
P
L
Y
-
E
T
L
N
E
S
S
A
V
A
L
A
V
K
L
G
L
T
L
T
C
Q
E
I
G
D
G
N
L
-
N
Y
V
F
H
----
I
Y
D
---
R
-
A
L
I
I
K
Q
A
V
---
P
Y
W
P
------------
L
T
I
D
----
R
A
R
I
E
S
--------------
S
-
A
L
I
--
R
Q
G
E
H
------
V
P
H
L
-
V
P
R
-
V
F
-
Y
-
S
D
T
E
M
A
V
T
V
M
E
D
L
S
H
L
K
--------
I
A
------
R
-
K
G
L
I
E
G
E
----
N
Y
PH
L
S
-
Q
-
H
I
-----
G
E
F
L
G
K
T
L
F
Y
-
S
S
D
-------
Y
A
---------
L
E
P
K
V
K
K
Q
L
V
K
-
Q
F
T
N
--
P
-------------
E
L
-----
C
D
I
----
T
E
R
-
L
--------
V
------
F
----------
T
D
P
F
F
D
H
D
-----
T
N
---------
D
F
-------
E
E
----------
E
L
-
R
--
P
F
--
V
---------
E
---------
K
L
-
W
N
N
-----
D
S
V
-
K
I
-
E
A
A
K
---------
L
K
---
K
S
F
L
T
S
A
--
E
T
L
I
H
G
D
L
H
T
G
S
I
F
-------------
A
--
S
E
-
H
---
E
T
K
V
-
I
-
D
------
P
E
F
A
-----
F
Y
G
-
P
I
--
G
F
D
V
G
--
Q
F
I
A
N
L
F
L
N
A
L
S
R
DG
A
D
R
E
P
L
Y
E
H
V
-------
N
Q
----
V
W
-------
E
-
T
F
E
E
T
----
F
S
E
A
W
---------
Q
--
K
D
------
S
L
D
V
Y
A
N
I
D
G
Y
L
T
D
T
L
S
H
I
F
E
E
A
--
I
G
F
A
G
C
E
-------
L
I
R
R
------
T
I
G
L
A
H
V
A
D
L
D
T
I
V
P
F
D
K
R
I
G
R
K
R
L
A
L
E
T
G
T
A
F
I
E
KRSEFKT
I
T
D
V
I
E
L
F
K
L
L
V
K--
50
Fugue
52.12
14%
5
- C5 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
------------------------------------------------------------------
A
K
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
M
S
P
-
A
K
V
Y
K
----
L
V
G
---
E
-
N
E
N
L
Y
L
-----
K
M
T
D
------------
S
R
Y
K
----
G
T
T
---------------------
Y
--
D
V
E
R
E
------
K
D
M
M
-
L
W
L
-
E
G
-
K
-
L
P
V
P
K
V
L
H
F
E
R
H
D
G
-------------------
W
-
S
N
L
L
M
S
E
----
A
D
---
G
-
V
-
L
--------
C
S
E
E
Y
E
D
E
-
Q
S
P
-------
E
K
---------
I
I
E
L
Y
A
E
C
I
R
L
-
F
H
S
I
DI
S
-------------
D
C
-----
P
Y
T
----
N
S
L
-
D
--------
S
------
R
----------
L
A
E
L
D
Y
L
L
-----
N
N
---------
D
L
-------
A
D
----------
V
D
-
C
--
E
N
--
W
---------
E
---------
E
D
-
T
P
F
-----
K
D
P
-
R
E
-
L
Y
D
F
---------
L
K
---
T
E
K
P
E
E
E
--
L
V
F
S
H
G
D
L
G
D
S
N
I
F
-------------
V
--
K
D
-
G
---
K
V
S
G
F
I
-
D
------
L
G
R
S
-----
G
R
A
D
-
K
--
W
Y
D
I
A
--
F
C
V
R
S
I
---------
R
E
D
---------------
I
----
G
E
-------
E
-
Q
Y
V
E
L
----
F
F
D
L
L
GI-------
K
--
P
D
------
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
--------------------------------------------------------------------------------------------
33
SP3
50.08
12%
17
- C5 -
-
1TQI
2
RIO2_ARCFU
A:
[1-282]
-------------------------------------------MN
I
A
E
L
Y
G
K
M
G
K
H
S
W
R
I
M
D
A
-
I
F
K
N
L
W
D
Y
E
Y
V
----
P
L
Q
---
L
I
S
S
H
A
R
I
-
G
E
E
K
A
----
R
N
I
---
L
-
K
Y
L
S
D
L
-----
R
V
V
Q
------------
N
--------
R
Q
K
D
Y
--------------
E
-
G
S
T
F
T
F
I
G
L
S
------
L
Y
S
L
-
H
R
L
-
V
R
-
S
-
G
K
V
D
---
A
I
G
K
L
M
G
E
G
K
--------
E
S
------
A
-
V
F
N
C
Y
S
E
----
K
F
---
G
-
E
-
C
V
-----
V
K
F
H
K
V
K
V
K
E
-
H
F
S
-------
V
L
---------
A
I
R
S
A
R
N
E
F
R
A
-
L
Q
K
L
--
Q
-------------
G
-------
L
A
----
V
P
K
-
V
--------
Y
------
A
----------
W
E
G
N
A
V
L
M
E
L
I
DA
K
E
---------
L
Y
-------
R
V
----------
R
V
-
E
--
N
P
------------
D
---------
E
V
-
L
D
M
-----
I
L
E
-
E
V
-
A
K
F
Y
-------------------
H
R
--
G
I
-
V
H
G
D
L
S
Q
Y
N
V
L
-------------
V
--
S
E
-
E
---
G
I
W
I
-
I
-
D
------
F
P
Q
S
-----
V
E
V
G
E
E
G
W
R
E
I
L
E
--
R
D
V
R
N
I
---------
I
T
Y
F
S
R
T
Y
R
T
-------
E
K
----
D
I
-------
N
-
S
A
I
D
R
----
I
L
Q
E
-------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
50.06
15%
23
- C5 -
-
5IGH
-
?
A:
[32-254]
-------------------------------------------------------------------------------------------
L
G
-
L
D
Y
R
I
----
V
I
A
T
V
-
D
D
G
R
R
W
V
L
-----
R
I
P
R
------------
R
A
E
---------------------------
V
S
A
--
K
V
E
P
E
------
A
R
V
L
-
A
M
L
-
K
N
-
R
L
P
-----
F
A
V
P
D
W
R
V
A
N
A
--------
E
L
V
A
Y
P
ML
E
-
D
S
T
A
M
V
I
----
Q
P
---
G
-
S
-
S
T
-----
P
D
W
V
V
--------
P
-------
Q
D
---------
S
E
V
F
A
E
S
F
A
T
A
-
L
A
A
L
--
H
-------------
A
V
-----
P
I
S
----
A
A
V
-
D
--------
A
G
M
L
I
R
T
P
----------
T
Q
A
R
Q
K
V
A
-----
D
D
---------
V
D
-------
R
V
----------
R
R
-
E
--
F
V
-----------------------
V
-
N
D
K
-----
R
L
H
-
R
W
-
Q
R
W
L
---------
D
D
---
D
S
S
W
P
D
F
--
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
-------------
I
--
D
N
T
E
R--
V
S
G
M
-
I
-
D
------
W
S
E
A
-----
R
V
D
-
D
P
--
A
I
D
M
A
--
A
H
L
M
V
F
---------
G
-------------------------------
E
-
E
G
L
A
K
----
L
L
L
T
Y
---------
E
--
A
A
----------------------------------------------------------------------------------------------------------------
18
HHSearch
49.87
21%
43
- C5 -
-
4R78
2
?
A:
[41-251]
-----------------------------------------------------------------------------------
S
V
E
Q
L
G
---
G
-
M
T
N
Q
N
----
Y
L
A
K
T
-
T
-
N
K
Q
Y
I
V
-----
K
F
F
G
------------
K
G
T
E
--------------------------
K
L
I
--
N
R
Q
D
E
------
K
Y
N
L
-
E
L
L
-
K
D
-
L
-
G
-----
L
D
V
K
N
Y
L
F
D
I
---------
E
-------
A
-
G
I
K
V
N
E
Y
----
I
E
---
S
-
A
I
T
L
-----
D
S
T
S
----------------------------
I
K
T
K
F
D
K
I
A
P
I
-
L
Q
T
I
--
H
-------------
T
S
-----
A
K
E
----
L
R
-----------
G
------
E
----------
F
A
P
F
E
E
I
K
-----
K
Y
---------
E
S
-------
L
I
----------
E
E
-
Q
--
I
P
YA
N
---------
Y
---------
E
S
-
V
R
N
-----
A
V
F
-
S
L
----
E
---------
K
R
---
L
A
D
L
G
V
D
--
R
K
S
C
H
I
D
L
V
P
E
N
F
I
-------------
E
--
S
P
Q
G
---
R
L
Y
L
-
I
-
D
------
W
E
Y
S
-----
S
M
N
-
D
P
--
M
W
D
L
A
--
A
L
F
L
E
S
---------
E
F
----------------------
T
-------
S
-
Q
E
E
E
T
----
F
L
S
H
Y
---------
E
--
S
D
----------------------------------------------------------------------------------------------------------------