@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : D2NS48_ROTMD: (2019-01-27 )
MTLSPLQLAAIVSAGVPGIYPVGAEPVREDSDDFDSAIIADSTGRRWRVRAPRRPDASMRLEAEHLILQSFSPGLRARLPFAVPTVAGTVPYAGGNVFVYTHIPGTIYDVDQLAELSRREVAARRPSLASIIAKDIATLHVMPEDIIYEADLPSYSSEQIRLRKNAELERAAATGKVPADLLAHWRAVLSPGPMWQFRPRVVHGDMGAENLVLHVTPTEARIVEVTGWSEVHVGDPAQDFAWLYSCQDIDFTDEAIEVYRQQMPQLPDAYLAQRANFYAEFAIAQWLTHTVEVGDRDGATHAVSMLLDIQDDLRASGELLGQEEVGPLVGPAE
Atome Classification :
(21 SA)
.........10-........-.-----20-........30........40-.-.---------..------..---..50.......--.-------60..-......70........80........-90-.---.....----..100...-....110.....----..-120---......-..130.......-140-.......150.......160........170.-----.----..----...---180-.-..-.----..---...-190.......200.......210.......--220----....-----.....230.......240-.....--------.----.--------------------.250---------....----.....260---......-----------...270.------......280--....----...290..-.-----....300.......310.......320........330.---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTL
S
P
L
Q
L
A
A
--
I
V
S
AGVPG-I-----YP-VGAEPVREDSDDFD
S
A
I
IAD-S-T---------G
R
------
R
W
---
R
VRAPRRPDAS--
M
-------
R
L
E
A
-
E
H
L
I
L
Q
SFSPGLRARLPFAVPTVAGT-VP-Y---AGG
N
V
----
F
V
Y
T
HIPG-TIY
D
V
D
Q
L
A
E
L
S
----
R
R
-
E
V
----
A
ARR
P
S
-
L
A
S
I
I
A
K
D
I
A
T
L
-HVM-
P
E
D
I
I
YEADLPSYS
S
E
Q
I
-
R
LRKNA
E
L
E
R
AAA-----T----GK----V
P
A
---
D
---
L
-
L
A
-
H
----
W
R
---
A
VL-SPGPM
W
Q
F
RP
R
V
VHGDMGAE
N
L
V
L
H
VTPTE--
A
------
R
I
V
E
-----VTG
W
S
E
V
HVGD
P
A
Q
D
F
A
--
W
L
YSC--------Q----D--------------------ID-----------F
T
D
E
----
A
I
E
V
Y
R
-----
Q
QMPQL-----------
P
D
A
Y
L
A
Q
------
R
A
N
F
Y
A
E
F
A
--
I
A
Q
W
----
L
T
H
T
VEVG-D-----RDG
A
T
H
A
V
S
M
L
L
D
I
Q
D
D
L
R
A
S
G
E
LL-GQEEVGPLVGPAE---
12
PsiBlast_PDB
78.91
27%
-68
- C2 -
-
5IGR
3
?
A:
[20-233]
-------------------
G
-
L
-----
K
L
-
H
G
P
L
T
V
N
E
L
G
L
D
Y
R
I
V
I
A
T
V
-
D
-
D
---------
G
R
------
R
W
---
V
L
R
I
P
R
R
A
E
V
S
--
A
-------
K
V
E
P
-
E
A
R
V
L
A
M
----
L
K
N
R
L
P
F
A
V
P
D
W
R
------
V
---
A
N
A
E
L
----
V
A
Y
P
M
L
E
D
-
S
T
A
M
V
I
Q
P
G
S
S
T
----
P
D
-
W
V
----
V
P
Q
D
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
-
H
A
V
-
P
I
S
A
A
V
D
A
G
M
L
I
R
T
P
T
Q
A
-
R
Q
K
V
A
D
D
V
D
R
V
R
R
-----
E
----
F
V
----
V
N
D
---
K
---
R
-
L
H
-
R
----
W
Q
---
R
W
L
-
D
D
D
S
S
W
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T
E
-----------
R
V
S
G
-----
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
78.59
23%
-31
- C2 -
-
5IGH
-
?
A:
[8-299]
---
D
T
S
Q
L
Y
A
--
L
A
A
R
-
H
-
G
-
L
-----
K
L
H
G
P
L
T
V
N
--
E
L
G
L
D
Y
R
I
V
I
A
T
-
V
-
D
D--------
G
R
------
R
W
---
V
L
R
I
P
R
R
A
E
V
S
--
A
-------
K
V
E
P
-
E
A
R
V
L
A
M
L
K
----
N
R
L
P
F
A
V
P
D
W
R
V
A
-
N
A
-
E
L
--
V
A
Y
P
M
LEDS
T
A
M
V
I
Q
P
G
-
S
S
T
P
D
W
V
V
P
----------------
Q
D
-
S
E
V
-
F
A
E
S
F
A
T
A
L
A
A
L
-
H
A
V
-
P
I
S
A
A
V
D
A
G
M
L
I
R
T
P
T
Q
A
-
R
Q
K
V
A
D
D
V
D
R
V
R
R
-----
E
----
F
V
----
V
N
D
---
K
---
R
-
L
H
-
R
----
W
Q
---
R
W
L
-
D
D
D
S
S
W
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
----
N
T-
E
------
R
V
S
G
-----
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
--
A
H
L
M
V
--------
F
----
G
--------------------
E
E
-----------
G
L
A
K
----
L
L
L
T
Y
E
-----
A
A
G
G
R
------------
V
W
P
R
L
A
H
------
H
I
A
E
R
L
A
F
G
--
A
V
T
Y
----
A
L
F
A
L
D
S
G
-
N
-----
E
E
Y
L
A
A
A
K
A
Q
L
A
A
-----------------------------
13
PsiBlast_PDB
78.52
27%
-67
- C2 -
-
5IGS
3
?
A:
[20-233]
-------------------
G
-
L
-----
K
L
-
H
G
P
L
T
V
N
E
L
G
L
D
Y
R
I
V
I
A
T
V
-
D
-
D
---------
G
R
------
R
W
---
V
L
R
I
P
R
R
A
E
V
S
--
A
-------
K
V
E
P
-
E
A
R
V
L
A
M
----
L
K
N
R
L
P
F
A
V
P
D
W
R
------
V
---
A
N
A
E
L
----
V
A
Y
P
M
L
E
D
-
S
T
A
M
V
I
Q
P
G
S
S
T
----
P
D
-
W
V
----
V
P
Q
D
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
-
H
A
V
-
P
I
S
A
A
V
D
A
G
M
L
I
R
T
P
T
Q
A
-
R
Q
K
V
A
D
D
V
D
R
V
R
R
-----
E
----
F
V
----
V
N
D
---
K
---
R
-
L
H
-
R
----
W
Q
---
R
W
L
-
D
D
D
S
S
W
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T
E
-----------
R
V
S
G
-----
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
78.48
27%
-67
- C2 -
-
5IGP
3
?
A:
[20-233]
-------------------
G
-
L
-----
K
L
-
H
G
P
L
T
V
N
E
L
G
L
D
Y
R
I
V
I
A
T
V
-
D
-
D
---------
G
R
------
R
W
---
V
L
R
I
P
R
R
A
E
V
S
--
A
-------
K
V
E
P
-
E
A
R
V
L
A
M
----
L
K
N
R
L
P
F
A
V
P
D
W
R
------
V
---
A
N
A
E
L
----
V
A
Y
P
M
L
E
D
-
S
T
A
M
V
I
Q
P
G
S
S
T
----
P
D
-
W
V
----
V
P
Q
D
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
-
H
A
V
-
P
I
S
A
A
V
D
A
G
M
L
I
R
T
P
T
Q
A
-
R
Q
K
V
A
D
D
V
D
R
V
R
R
-----
E
----
F
V
----
V
N
D
---
K
---
R
-
L
H
-
R
----
W
Q
---
R
W
L
-
D
D
D
S
S
W
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T
E
-----------
R
V
S
G
-----
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
78.36
27%
-67
- C2 -
-
5IGT
3
?
A:
[20-233]
-------------------
G
-
L
-----
K
L
-
H
G
P
L
T
V
N
E
L
G
L
D
Y
R
I
V
I
A
T
V
-
D
-
D
---------
G
R
------
R
W
---
V
L
R
I
P
R
R
A
E
V
S
--
A
-------
K
V
E
P
-
E
A
R
V
L
A
M
----
L
K
N
R
L
P
F
A
V
P
D
W
R
------
V
---
A
N
A
E
L
----
V
A
Y
P
M
L
E
D
-
S
T
A
M
V
I
Q
P
G
S
S
T
----
P
D
-
W
V
----
V
P
Q
D
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
-
H
A
V
-
P
I
S
A
A
V
D
A
G
M
L
I
R
T
P
T
Q
A
-
R
Q
K
V
A
D
D
V
D
R
V
R
R
-----
E
----
F
V
----
V
N
D
---
K
---
R
-
L
H
-
R
----
W
Q
---
R
W
L
-
D
D
D
S
S
W
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T
E
-----------
R
V
S
G
-----
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.19
27%
-68
- C2 -
-
5IGJ
3
?
A:
[20-233]
-------------------
G
-
L
-----
K
L
-
H
G
P
L
T
V
N
E
L
G
L
D
Y
R
I
V
I
A
T
V
-
D
-
D
---------
G
R
------
R
W
---
V
L
R
I
P
R
R
A
E
V
S
--
A
-------
K
V
E
P
-
E
A
R
V
L
A
M
----
L
K
N
R
L
P
F
A
V
P
D
W
R
------
V
---
A
N
A
E
L
----
V
A
Y
P
M
L
E
D
-
S
T
A
M
V
I
Q
P
G
S
S
T
----
P
D
-
W
V
----
V
P
Q
D
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
-
H
A
V
-
P
I
S
A
A
V
D
A
G
M
L
I
R
T
P
T
Q
A
-
R
Q
K
V
A
D
D
V
D
R
V
R
R
-----
E
----
F
V
----
V
N
D
---
K
---
R
-
L
H
-
R
----
W
Q
---
R
W
L
-
D
D
D
S
S
W
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T
E
-----------
R
V
S
G
-----
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
77.91
18%
-25
- C2 -
-
3HAM
3
?
A:
[1-299]
---
M
V
N
L
D
A
E
--
I
Y
E
H
L
N
K
Q
-
I
-----
K
I
-
N
E
L
R
Y
L
S
S
G
D
D
S
D
T
F
L
C
----------------
N
E
------
Q
Y
---
V
V
K
V
P
K
R
D
S
V
R
--
I
-------
S
Q
K
R
-
E
F
E
L
Y
R
F
L
E
N
---
C
K
L
S
Y
Q
I
P
A
-----
V
V
-
Y
---
Q
S
D
R
F
----
N
I
M
K
Y
I
K
G
-
E
R
I
T
Y
E
Q
Y
H
K
L
S
-------------
E
K
E
K
D
A
-
L
A
Y
D
E
A
T
F
L
K
E
L
-
H
S
I
E
I
D
C
S
V
S
L
F
S
D
A
L
V
N
K
K
D
K
-
F
L
Q
D
K
K
L
L
I
S
I
L
E
K
E
QLL
T
----
D
E
----
M
L
E
---
H
---
I
-
E
T
-
I
----
Y
E
---
N
I
L
-
N
N
A
V
L
F
K
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
----
N
--
N
------
R
L
F
G
-----
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
--
C
L
L
D
C
--------
S
----
T
--------------------
D
D
-----------
F
G
K
E
----
F
G
R
K
V
L
-----
K
Y
Y
Q
H
K
-----------
A
P
E
V
A
E
R
------
K
A
E
L
N
D
V
Y
W
--
S
I
D
Q
----
I
I
Y
G
Y
E
R
K
-
D
-----
R
E
M
L
I
K
G
V
S
E
L
L
Q
T
Q
A
E
M
F
I
F
---------------------
15
PsiBlast_PDB
77.45
27%
-67
- C2 -
-
5IGH
-
?
A:
[20-233]
-------------------
G
-
L
-----
K
L
-
H
G
P
L
T
V
N
E
L
G
L
D
Y
R
I
V
I
A
T
V
-
D
-
D
---------
G
R
------
R
W
---
V
L
R
I
P
R
R
A
E
V
S
--
A
-------
K
V
E
P
-
E
A
R
V
L
A
M
----
L
K
N
R
L
P
F
A
V
P
D
W
R
------
V
---
A
N
A
E
L
----
V
A
Y
P
M
L
E
D
-
S
T
A
M
V
I
Q
P
G
S
S
T
----
P
D
-
W
V
----
V
P
Q
D
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
-
H
A
V
-
P
I
S
A
A
V
D
A
G
M
L
I
R
T
P
T
Q
A
-
R
Q
K
V
A
D
D
V
D
R
V
R
R
-----
E
----
F
V
----
V
N
D
---
K
---
R
-
L
H
-
R
----
W
Q
---
R
W
L
-
D
D
D
S
S
W
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T
E
-----------
R
V
S
G
-----
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
77.23
23%
-26
* C2 *
-
5IGI
3
?
A:
[8-299]
---
D
T
S
Q
L
Y
A
--
L
A
A
R
-
H
-
G
-
L
-----
K
L
H
G
P
L
T
V
N
--
E
L
G
L
D
Y
R
I
V
I
A
T
-
V
-
D
D--------
G
R
------
R
W
---
V
L
R
I
P
R
R
A
E
V
S
--
A
-------
K
V
E
P
-
E
A
R
V
L
A
M
L
K
----
N
R
L
P
F
A
V
P
D
W
R
V
A
-
N
A
-
E
L
--
V
A
Y
P
M
LEDS
T
A
-
V
I
Q
P
G
-
S
S
T
P
D
W
V
V
P
----------------
Q
D
-
S
E
V
-
F
A
E
S
F
A
T
A
L
A
A
L
-
H
A
V
-
P
I
S
A
A
V
D
A
G
M
L
I
R
T
P
T
Q
A
-
R
Q
K
V
A
D
D
V
D
R
V
R
R
-----
E
----
F
V
----
V
N
D
---
K
---
R
-
L
H
-
R
----
W
Q
---
R
W
L
-
D
D
D
S
S
W
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
----
N
T-
E
------
R
V
S
G
-----
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
--
A
H
L
M
V
--------
F
----
G
--------------------
E
E
-----------
G
L
A
K
----
L
L
L
T
Y
E
-----
A
A
G
G
R
------------
V
W
P
R
L
A
H
------
H
I
A
E
R
L
A
F
G
--
A
V
T
Y
----
A
L
F
A
L
D
S
G
-
N
-----
E
E
Y
L
A
A
A
K
A
Q
L
A
A
-----------------------------
16
PsiBlast_PDB
74.95
20%
-27
- C2 -
-
3HAM
3
?
A:
[28-293]
-------------------------------------
D
D
S
D
T
F
--------
L
-
C
---------
N
E
------
Q
Y
---
V
V
K
V
P
K
R
D
S
V
R
--
I
-------
S
Q
K
R
-
E
F
E
L
Y
R
F
L
E
---
N
C
K
L
S
Y
Q
I
P
A
V
V
------
Y
---
Q
S
D
R
F
----
N
I
M
K
Y
I
K
G
-
E
R
I
T
Y
E
Q
Y
H
K
L
S
----
E
K
-
E
--------
K
D
A
-
L
A
Y
D
E
A
T
F
L
K
E
L
-
H
S
I
-
E
I
D
C
S
V
S
L
F
S
D
A
L
V
N
K
K
D
-
K
F
L
Q
D
K
K
L
L
I
S
I
L
-----
E
----
K
E
QL--
L
T
D
---
E
---
M
-
L
E
-
H
I
E
T
I
Y
E
---
N
I
L
-
N
N
A
V
L
F
K
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
----
N
--
N
------
R
L
F
G
-----
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
--
C
L
L
D
C
--------
S
----
T
--------------------
D
D
-----------
F
G
K
E
F
G
R
K
V
L
K
Y
Y
Q
-----
H
K
A
P
E
----------------
V
A
E
------
R
K
---
A
E
L
N
--
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
E
R
K
-
D
-----
R
E
M
L
I
K
G
V
S
E
L
L
Q
T
Q
---------------------------
9
PsiBlast_PDB
74.44
27%
-67
- C2 -
-
5IGI
3
?
A:
[20-233]
-------------------
G
-
L
-----
K
L
-
H
G
P
L
T
V
N
E
L
G
L
D
Y
R
I
V
I
A
T
V
-
D
-
D
---------
G
R
------
R
W
---
V
L
R
I
P
R
R
A
E
V
S
--
A
-------
K
V
E
P
-
E
A
R
V
L
A
M
----
L
K
N
R
L
P
F
A
V
P
D
W
R
------
V
---
A
N
A
E
L
----
V
A
Y
P
M
L
E
D
-
S
T
A
-
V
I
Q
P
G
S
S
T
----
P
D
-
W
V
----
V
P
Q
D
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
-
H
A
V
-
P
I
S
A
A
V
D
A
G
M
L
I
R
T
P
T
Q
A
-
R
Q
K
V
A
D
D
V
D
R
V
R
R
-----
E
----
F
V
----
V
N
D
---
K
---
R
-
L
H
-
R
----
W
Q
---
R
W
L
-
D
D
D
S
S
W
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T
E
-----------
R
V
S
G
-----
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
74.30
16%
-17
- C2 -
-
3TDW
1
?
A:
[4-300]
---
N
K
L
H
Y
T
T
--
M
I
M
T
Q
F
P
D
-
I
-----
S
I
-
Q
S
V
E
S
L
--
G
E
G
F
R
N
Y
A
I
L
V
--------------
N
G
------
D
W
---
V
F
R
F
P
K
S
Q
Q
G
A
--
D
-------
E
L
N
K
-
E
I
Q
L
L
P
L
L
V
----
G
C
V
K
V
N
I
P
Q
Y
V
Y
I
-
G
K
R
S
---
D
G
N
P
F
----
V
G
Y
R
K
V
Q
G
-
Q
I
L
G
E
D
G
M
A
V
L
P
--------
D
----
D
A
-
K
D
R
-
L
A
L
Q
L
A
E
F
M
N
E
L
-
S
A
F
-
P
V
E
T
A
I
S
A
G
V
P
V
T
N
L
K
N
K
-
I
L
L
L
S
E
A
V
E
D
Q
V
F
----------
P
L
----
L
D
E
---
S
L
R
D
Y
-
L
T
L
R
----
F
Q
---
S
Y
M
-
T
H
P
V
Y
T
R
Y
T
P
R
L
I
H
G
D
L
S
P
D
H
F
L
T
N
L
N
S
R
Q
--
T
------
P
L
T
G
-----
I
I
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
V
--
Y
L
L
E
D
--------
C
----
G
--------------------
E
L
------------
F
T
R
----
Q
V
M
A
Y
R
-----
G
E
V
D
--------------
L
D
T
H
I
R
------
K
V
S
L
F
V
T
F
D
--
Q
V
S
Y
----
L
L
E
G
L
R
A
R
-
D
-----
Q
D
W
I
S
E
G
L
E
L
L
E
E
D
K
A
N
N
------------------------
17
PsiBlast_PDB
71.49
20%
-29
- C2 -
-
3HAV
2
?
A:
[28-293]
-------------------------------------
D
D
S
D
T
F
--------
L
-
C
---------
N
E
------
Q
Y
---
V
V
K
V
P
K
R
D
S
V
R
--
I
-------
S
Q
K
R
-
E
F
E
L
Y
R
F
L
E
---
N
C
K
L
S
Y
Q
I
P
A
V
V
------
Y
---
Q
S
D
R
F
----
N
I
M
K
Y
I
K
G
-
E
R
I
T
Y
E
Q
Y
H
K
L
S
----
E
K
-
E
--------
K
D
A
-
L
A
Y
D
E
A
T
F
L
K
E
L
-
H
S
I
-
E
I
D
C
S
V
S
L
F
S
D
A
L
V
N
K
K
D
-
K
F
L
Q
D
K
K
L
L
I
S
I
L
-----
E
----
K
E
QL--
L
T
D
---
E
---
M
-
L
E
-
H
I
E
T
I
Y
E
---
N
I
L
-
N
N
A
V
L
F
K
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
----
N
--
N
------
R
L
F
G
-----
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
--
C
L
L
D
C
--------
S
----
T
--------------------
D
D
-----------
F
G
K
E
F
G
R
K
V
L
K
Y
Y
Q
-----
H
K
A
P
E
----------------
V
A
E
------
R
K
---
A
E
L
N
--
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
----
D
-----
R
E
M
L
I
K
G
V
S
E
L
L
Q
T
Q
---------------------------
57
HHSearch
71.34
15%
-38
- C- -
-
3N4U
-
?
A:
[3-298]
-
T
Y
T
F
D
Q
V
E
K
--
A
I
E
Q
L
Y
P
D
-
F
-----
T
I
-
N
T
I
E
I
S
--
G
E
G
N
D
C
I
A
Y
E
I
--------------
N
R
------
D
F
---
I
F
K
F
P
K
H
S
R
G
S
--
T
-------
N
L
F
N
-
E
V
N
I
L
K
R
I
H
----
N
K
L
P
L
P
I
P
E
V
V
F
T
-
G
M
-
P
S
ET
Y
Q
M
S
F
----
A
G
F
T
K
I
K
G
-
V
P
L
T
P
L
L
L
N
N
L
P
--------
K
----
Q
S
-
Q
N
Q
-
A
A
K
D
L
A
R
F
L
S
E
L
-
H
S
I
-
N
I
S
G
F
K
S
N
L
V
-----
L
D
F
-
R
E
K
I
N
E
D
N
K
K
I
K
K
-----
L
L
S
--
R
E
----
L
K
G
P
Q
M
K
---
K
-
V
D
-
D
----
F
Y
---
R
D
I
L
E
N
E
I
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
----
T
EK
N
------
T
I
C
G
-----
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
--
S
L
M
E
D
DEE-----
Y
----
G
--------------------
M
E
-----------
F
V
S
K
----
I
L
N
H
Y
K
-----
H
K
D
I
---------------
P
T
V
L
E
------
K
Y
R
M
K
E
K
Y
W
--
S
F
E
K
----
I
I
Y
G
K
E
Y
G
-
Y
-----
M
D
W
Y
E
E
G
L
N
E
I
R
S
I
----------------------------
37
Fugue
69.88
18%
9
- C2 -
-
4OCV
2
?
A:
[24-378]
T
N
E
A
L
F
D
V
A
S
H
F
A
L
E
G
T
V
D
S
-
I
-----
E
P
-
Y
G
D
G
H
I
-------
N
T
T
Y
L
V
T
-
T
-
D
---------
G
P
------
R
Y
I
L
Q
R
M
N
T
G
I
F
P
D
T
V
--
N
-------
L
M
R
N
-
V
E
L
V
T
S
T
L
K
A
Q
G
K
E
T
L
D
I
V
R
T
T
S
G
D
T
W
A
E
-
I
---
D
G
G
A
W
----
R
V
Y
K
F
I
E
H
-
T
M
S
Y
N
L
V
P
N
P
D
V
----
F
R
-
E
A
----
G
R
A
F
G
D
-
F
Q
N
F
L
S
G
F
D
A
N
Q
---
L
-
T
E
T
I
A
H
F
H
D
T
P
H
R
F
E
D
F
K
-
K
A
L
A
A
D
E
L
G
R
A
A
G
-----
C
----
G
P
----
E
I
E
---
F
---
Y
-
L
S
-
H
----
A
D
QYA
V
V
M
-
D
G
L
R
D
G
S
I
P
L
R
V
T
H
N
D
T
K
L
N
N
I
L
M
D
A
T
T
G
K
--
A
------
R
A
I
I
DLDTI
M
P
G
S
M
L
F
D
F
G
D
S
I
R
F
G
A
ST
A
L
E
D
E
--------
R
----
D
--------------------
L
D
K
V
H
F
S
T
E
L
F
R
A
Y
T
E
G
----
F
V
G
E
L
R
-----
D
S
I
T
A
R
-----------
E
A
E
L
L
P
F
------
S
G
N
L
L
T
M
E
C
--
G
M
R
F
----
L
A
D
Y
L
E
G
D
-
V
-----
Y
F
A
T
K
Y
P
E
H
N
L
V
R
S
R
T
Q
I
K
L
V
R
E
M
E
Q
R
A
D
E
T
R
A
I
V
A
D
V
M
E
T
T
55
HHSearch
65.71
18%
-5
- C2 -
-
5UXA
-
?
A:
[2-299]
-
S
K
D
I
K
Q
V
I
E
--
I
A
K
K
H
N
L
F
-
L
-----
K
E
-
E
T
I
Q
F
N
--
E
S
G
L
D
F
Q
A
V
F
A
Q
-
D
N
N
---------
G
I
------
D
W
---
V
L
R
L
P
R
R
E
D
V
M
--
P
-------
R
T
K
V
-
E
K
Q
A
L
D
L
V
N
K
---
Y
A
I
S
F
Q
A
P
N
W
I
I
Y
-
T
--------
E
E
L
----
I
A
Y
K
K
L
D
G
-
V
P
A
G
T
I
D
H
N
I
G
N
YIWE
I
D
-
I
N
----
N
V
-
P
E
L
-
F
H
K
S
L
G
R
V
L
A
E
L
-
H
S
I
-
P
S
N
K
A
A
A
L
D
L
V
V
H
T
P
E
E
A
-
R
M
S
M
K
Q
R
M
D
A
V
R
A
-----
K
----
F
G
----
V
G
E
---
N
---
L
-
W
N
-
R
----
W
Q
---
A
W
L
-
N
D
D
D
M
W
P
K
K
T
G
L
I
H
G
D
V
H
A
G
H
T
M
I
D
K
---
D
--
A
------
N
V
T
G
-----
L
I
D
W
T
E
A
K
V
T
D
V
S
H
D
F
I
--
F
N
Y
R
A
--------
F
----
G
--------------------
E
E
-----------
G
L
E
A
----
L
I
L
A
Y
K
-----
E
I
G
G
Y
Y
------------
W
P
K
M
K
E
------
H
I
I
E
L
N
A
A
Y
--
P
V
S
I
----
A
E
F
A
L
V
S
G
-
I
-----
E
E
Y
E
Q
M
A
K
E
A
L
E
V
-----------------------------
51
HHSearch
65.22
19%
-9
- C2 -
-
5UXD
2
?
A:
[4-299]
-
P
E
D
L
D
A
L
L
D
--
L
A
A
R
H
G
L
D
-
L
-----
D
G
-
G
T
L
R
T
E
--
E
I
G
L
D
F
R
V
A
F
A
R
A
H
-
D
---------
G
G
------
D
W
---
V
L
R
L
P
R
R
P
D
V
L
--
E
-------
R
A
A
V
-
E
G
R
L
L
A
M
L
A
----
P
H
L
D
V
A
V
P
D
W
R
I
S
-
T
--------
S
E
L
----
I
A
Y
P
L
L
P
G
-
S
P
G
L
T
V
A
A
D
G
E
V
----
S
W
H
V
D
----
M
A
-
S
T
V
-
Y
A
R
S
L
G
S
V
V
A
Q
L
-
H
A
V
-
D
A
E
A
A
A
A
T
G
I
E
V
R
S
P
A
Q
V
-
R
G
A
W
R
Q
D
L
A
R
V
G
A
-----
E
----
F
E
----
I
A
P
---
A
---
L
-
R
E
-
R
----
W
E
---
A
W
L
-
A
D
D
G
C
W
P
G
H
S
V
L
T
H
G
E
L
Y
P
A
H
T
L
V
E
----
D
--
E
------
R
I
T
A
-----
V
L
D
W
T
T
A
A
V
G
D
P
A
K
D
L
M
--
F
H
Q
V
S
--------
A
----
P
--------------------
S
A
-----------
I
F
E
V
----
A
L
Q
A
Y
A
-----
E
G
G
G
R
P
------------
W
P
G
L
A
R
------
H
--
C
T
E
M
F
S
A
A
P
L
G
Y
----
G
L
Y
A
L
A
T
G
-
E
-----
A
A
H
R
E
A
A
A
A
A
L
N
P
P
E
E
--------------------------
29
Fugue
64.97
14%
-38
- C2 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
T
D
I
T
E
D
E
L
R
N
--
F
L
T
Q
-----------
Y
D
-
V
G
S
L
T
S
Y
K
G
I
A
E
N
S
N
F
L
L
H
T
-
T
-
K
---------
D
P
------
L
I
---
L
T
L
Y
E
K
K
N
D
L
P
--
F
-------
F
L
G
L
M
Q
H
L
A
A
K
----
G
L
S
C
P
L
P
L
P
R
K
D
G
E
L
L
-
G
E
-
L
---
S
G
R
P
A
----
A
L
I
S
F
L
E
G
M
W
L
R
K
-----------------------
P
E
A
K
-
H
C
R
E
V
G
K
A
L
A
-
A
M
H
L
A
-
S
E
G
F
E
I
K
R
P
N
A
L
S
V
D
G
W
K
-
V
L
W
D
K
S
E
E
R
A
D
E
V
-----
E
----
K
G
----
L
R
E
---
E
---
I
-
R
P
-
E
----
I
D
---
Y
L
A
-
A
H
W
P
K
-
D
L
P
A
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
----
G
--
D
------
E
L
S
G
-----
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
--
I
C
L
N
A
WCFEKDGA
Y
----
N
--------------------
V
T
-----------
K
G
K
A
----
L
L
E
G
Y
Q
-----
S
V
R
P
-
L
-----------
S
E
A
E
L
E
A
------
L
P
L
L
S
R
G
S
A
--
L
R
F
F
----
L
T
R
L
Y
D
W
L
T
T
-----
P
A
G
A
L
V
V
K
K
D
P
L
E
Y
L
R
K
L
R
F
H
R
T
I
A
-
N
V
A
E
Y
G
L
A
--------
61
HHSearch
64.72
14%
-14
- C2 -
-
5FUT
10
CHKA_HUMAN
A:
[8-377]
---
T
R
R
R
A
Y
L
--
W
C
K
E
F
L
P
G
A
W
RGLRE
D
E
-
F
H
I
S
V
I
--
R
G
G
L
S
N
M
L
F
Q
C
S
-
L
-
P
DTTATLGDE
P
R
------
K
V
---
L
L
R
L
Y
G
-----G
A
E
-------
A
M
V
L
-
E
S
V
M
F
A
I
L
A
-----
E
R
S
L
G
-
P
K
L
Y
G
I
-
F
P
-
Q
-------
G
----
R
L
E
Q
F
I
P
S
-
R
R
L
D
T
E
E
L
S
-------------------
L
P
D
-
I
S
A
E
I
A
E
K
M
A
T
F
-
H
G
M
-
K
M
P
F
N
K
E
P
--
K
--
W
L
F
G
T
-
M
E
K
Y
L
K
E
V
L
R
I
K
F
T----
E
E
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
---
E
-
L
E
-
N
----
L
R
---
S
L
L
-
E
S
---
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
----
E
--
G
RENSEK
Q
K
L
M
-----
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
--
N
H
F
C
E
--------
W
----
M
YDYSYEKYPF
F
R
A
N
IRKYPT
K
K
-----------
Q
Q
L
H
----
F
I
S
S
Y
L
-----
P
A
F
Q
N
D
FENLS
T
E
E
K
S
I
I
K
E
E
M
L
L
------
E
V
N
R
F
A
L
A
S
--
H
F
L
W
----
G
L
W
S
I
V
Q
A
-
K
ISSIE
F
G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
F
H
Q
K
R
K
L
G
--------------------
41
SP3
64.33
14%
-66
- C2 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
---------
G
--
S
P
A
A
W
V
E
R
-
L
-----
F
G
-
Y
D
W
A
Q
Q
T
-
I
G
C
S
D
A
A
V
F
R
L
S
-
A
-
Q
---------
G
R
------
P
V
---
L
F
V
K
T
D
L
S
G
A
L
--
N
-------
E
L
Q
D
-
E
A
A
R
L
S
W
L
A
T
T
-----
G
V
P
C
A
A
V
L
D
V
-
V
T
-
E
---
A
G
R
D
W
----
L
L
L
G
E
V
P
G
-
Q
D
L
L
S
S
H
L
A
-------------------
P
A
E
-
K
V
S
I
M
A
D
A
M
R
R
L
-
H
T
L
-
D
P
A
T
C
P
F
D
H
Q
A
K
H
R
I
E
R
A
-
R
T
R
M
E
A
G
L
V
D
Q
D
D
-----
L
----
D
E
----
E
H
Q
---
G
---
L
A
P
A
-
E
----
L
F
---
A
R
L
-
K
A
R
M
P
D
G
E
D
L
V
V
T
H
G
D
A
C
L
P
N
I
M
V
E
----
N
--
G
------
R
F
S
G
-----
F
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
--
L
A
T
R
D
--------
I
A
E
E
L
G
--------------------
G
E
-----------
W
A
D
R
----
F
L
V
L
Y
G
----------------------
I
A
A
P
D
S
Q
------
R
I
A
F
Y
R
L
L
D
--
E
F
F
--------------------------------------------------------------
26
Fugue
58.29
15%
-11
- C2 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
--
T
L
P
A
V
I
S
R
--
W
L
S
S
V
L
P
G
-
G
AA---
P
E
-
V
T
V
E
S
G
V
D
S
T
G
M
S
S
E
T
I
I
L
T
-
A
-
R
---------
W
Q
Q
DG
R
S
I
Q
Q
---
K
L
V
A
R
V
A
P
A
A
E
--
D
VPVFPTY
R
L
D
H
-
Q
F
E
V
I
R
L
V
G
E
L
T
D
V
P
V
P
-
R
V
R
W
I
E
T
T
-
G
D
-
V
---
L
G
T
P
F
----
F
L
M
D
Y
V
E
G
-
V
V
P
P
D
V
M
P
Y
T
F
G
----
D
N
-
W
F
ADAP
A
E
R
Q
R
Q
-
L
Q
D
A
T
V
A
A
L
A
T
L
-
H
S
I
-
P
N
A
Q
N
T
F
S
F
L
T
D
T
T
L
H
R
H
F
N
W
V
R
S
W
Y
D
F
A
V
E
G
-----
I
----
G
R
----
S
P
L
L
--
E
---
R
-
T
F
-
E
----
W
L
---
Q
S
H
-
W
P
D
D
A
A
A
R
E
P
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
----
D
--
F
------
Q
P
V
A
-----
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
--
W
M
I
F
A
--------
H
----
R
--------------------
V
F
-----------
Q
E
L
A
----
G
L
A
T
L
P
GLPEV
M
R
E
D
D
V
-----------
R
A
T
Y
Q
A
L
TG
V
E
L
G
D
L
H
W
F
Y
V
Y
S
--
G
V
M
W
----
A
C
V
F
M
R
T
G
-
A
-----
R
R
V
H
F
G
E
I
E
K
P
D
D
V
E
S
L
F
Y
H
A
G
L
M
K
-
H
L
L
G
E
E
H
---------