@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : D2Q2Q9_KRIFD: (2019-01-27 )
MAAPAQSEQMRRLAGLLGVKLDPFSTGGESLTFGITGTELLVTIPTEPGEQDVQRQAELTRRVADRISIPVPEIVRVVAEAEAVVVRRLPGVPLIAVPTPQRAALTRSVALAVGTVLAELHTWDRDGYADLAPVDEYSPEEWRAETAELVSDLTPLLTTDQRDDVRRFLGRPAPRPAGRHVLSHNDLGIEHILVSPDAVTGVIDWNDAAITDPAYDFGLLLRDLGPEALRTALARYAHQIGGDPELLERASYYAVCALLEDLAFGHETGRVEYVAKSLHGWRWTFQAAG
Atome Classification :
(29 SA)
---.........10.....--.--.--.20........30-...-.---.---...40.-.....---.-.--50........60.....--...70........-----------80------..--...-----..-----..90.......-.100--------.---....-..110-.......120.......130-.-.--..--...---.140---...-.....--150...--.---------------..---.----..160-------..----.....170-.--.---.....-..180........190..--.--.----.----..200.......210.......220-...----.----.-----....230-.......240--.-....-..250.....-----..--260.--......270.......280.......-----------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---MAAP
A
Q
S
E
Q
M
R
R
L
A
G
L
--L--G--VKLDPFSTGG
E
S
L
-
T
F
G
-I---T---G
T
E
L
L
V
-
T
IPTE---P-
G
--
E
Q
D
V
Q
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Q
A
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L
T
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R
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R--ISI
P
V
P
E
I
V
R
V
V
A
-----------
E
-------
A
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--
A
V
V
-----
V
R-----RLPGV
P
L
I
AVP-T
P
Q
R
--------
A
---
A
L
T
R
-
S
V
A
L
A
-
V
G
T
V
L
A
E
L
HTWDRDGYADL--A-P--VD--EY
S
---
P
E
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----
W
R
A
-
E
T
A
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L
--
V
--
S
D
L
--
T
---------------
P
L---L----TTD
Q
R
-------
D
D
----
V
R
R
F
LG---R--P---APRPA-G
R
H
-VLSHNDLG
I
E
H
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L
V--S--P----D----
A
V
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V
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DWNDAAITDP
A
Y
D
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L
---
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D----L----
G
-----
P
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QIGG--
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A
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C
A
-----
L
L
--
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D
L
A--FGHETG
R
V
E
Y
V
A
K
SLHG
W
R
W
T
F
QAAG-----------------------------------------------------------
59
HHSearch
77.33
21%
19
- C2 -
-
5UXD
2
?
A:
[8-297]
-------
D
A
L
L
D
L
A
A
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L
--
D
LD
G
--
G
T
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G
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A
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R
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A
A
A
A
A
L
N
P
P
----------------------------------------------------------------
67
HHSearch
77.03
22%
17
- C2 -
-
3HAM
3
?
A:
[16-293]
------------------
I
--
K
--
I
--
N
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L
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Y
L
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D
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---
N
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K
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----
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K
D
R
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M
L
I
K
G
V
S
E
L
L
Q
T
Q
---------------------------------------------------------------
58
HHSearch
76.01
22%
18
- C- -
-
3N4U
-
?
A:
[13-298]
------------
I
E
Q
L
Y
P
D
F-
T
--
I
--
N
T
I
E
I
S
G
E
G
N
D
C
I
-
A
Y
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-
I
---
N
---
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F
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-----------
P
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ETYQ--
M
S
--
F
A
G
-----
F
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-----
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I
K
G
V
P
L
T
P
L
L
--
L
N
N
--------
L
P
K
-
Q
S
Q
N
-
Q
A
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K
D
-
L
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R
F
L
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I
N
I
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K
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N
--
L
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V
------
L
D
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---
R
E
K
----
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N
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D
N
K
K
I
--
K
--
K
L
L
--
S
---------------
R
E
---
L
K
G
P
Q
M
K
K
V
D
-------
D
F
----
Y
R
D
I
L
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------
N
---
E
I
Y
F
K
-
Y
Y
P
-
C
L
I
H
N
D
F
S
S
D
H
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L
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--
D
--
T
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N
----
T
I
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G
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F
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P
D
N
D
F
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L
---
M
E
D
DEE-
Y
----
G
-----
M
E
F
V
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K
I
-
L
N
H
Y
K
H
K
D
----
I
-
P
T
V
L
-
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K
Y
R
M
K
E
K
Y
W
-----
S
F
--
E
K
I
I
--
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
I
R
S
I
----------------------------------------------------------------
4
PsiBlast_PDB
75.16
22%
-5
- C2 -
-
5C4L
1
?
A:
[51-316]
-----------------------------------
G
N
D
C
I
-
A
Y
E
-
I
---
N
----
R
D
F
I
F
-
K
F
P
K
H
---
S
R
G
--
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
-----------
P
-------
S
E
--
T
Y
Q
-----
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
-
L
N
N
L
--------
P
---
K
Q
S
Q
-
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
--
L
-
V
--
L
D
---------------
F
R
E
-
K
I
N
E
D
--
N
--
K
K
I
--
K
---------------
K
L
---
L
----
S
R
E
L
K
G
P
Q
M
K
K
V
D
D
----
F
Y
R
D
I
L
---
E
--
N
---
E
I
Y
F
K
-
Y
Y
P
-
C
L
I
H
N
D
F
S
S
D
H
I
L
F
--
D
TE
K
----
N
----
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
---
M
E
D
DEE-
Y
----
G
-----
M
E
F
V
S
K
I
-
L
N
H
Y
K
H
K
--
D
--
I
-
P
T
V
L
-
E
K
Y
R
M
K
E
K
Y
W
-----
S
F
--
E
K
I
I
--
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
I
R
------------------------------------------------------------------
3
PsiBlast_PDB
74.83
22%
-6
- C2 -
-
5C4K
1
?
A:
[51-316]
-----------------------------------
G
N
D
C
I
-
A
Y
E
-
I
---
N
----
R
D
F
I
F
-
K
F
P
K
H
---
S
R
G
--
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
-----------
P
-------
S
E
--
T
Y
Q
-----
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
-
L
N
N
L
--------
P
---
K
Q
S
Q
-
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
--
L
-
V
--
L
D
---------------
F
R
E
-
K
I
N
E
D
--
N
--
K
K
I
--
K
---------------
K
L
---
L
----
S
R
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L
K
G
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K
K
V
D
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----
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Y
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--
N
---
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I
Y
F
K
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Y
Y
P
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L
I
H
N
D
F
S
S
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L
F
--
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TE
K
----
N
----
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
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D
N
D
F
I
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L
---
M
E
D
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Y
----
G
-----
M
E
F
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S
K
I
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L
N
H
Y
K
H
K
--
D
--
I
-
P
T
V
L
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E
K
Y
R
M
K
E
K
Y
W
-----
S
F
--
E
K
I
I
--
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
I
R
------------------------------------------------------------------
66
HHSearch
74.74
23%
9
- C2 -
-
4DCA
1
?
A:
[36-301]
-----------------
Q
I
--
K
--
I
--
N
E
L
R
Y
L
S
S
G
D
D
S
D
-
T
F
L
-
C
---
N
---
E
Q
Y
-
V
V
-
K
V
P
K
R
---
D
-
S
V
-
R
I
S
Q
K
R
E
L
E
L
Y
R
F
L
E
N
C
K-
L
S
Y
Q
I
P
A
V
V
Y
Q
S
--------------------
D
R
--
F
N
I
-----
M
K
-----
Y
I
K
G
E
R
I
T
Y
E
Q
--
Y
H
K
--------
L
S
E
-
K
E
K
D
-
A
L
A
Y
D
-
E
A
T
F
L
K
E
L
H
S
I
E
I
D
C
S
V
S
L
--
F
-
S
D
-
A
L
--
V
N
K
---
K
D
K
----
F
L
Q
-
D
K
K
L
L
--
I
--
S
I
L
E
K
E
---------------
Q
L
---
L
----
T
D
E
M
L
-------
E
H
----
I
E
T
I
Y
E
N
I
L
S
--
N
---
A
V
L
F
K
-
Y
T
P
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L
V
H
N
D
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S
A
N
N
M
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--
R
--
N
----
N
----
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
L
---
L
D
C
STDD
F
----
G
-----
K
E
F
G
R
K
V
-
L
K
Y
Y
Q
H
K
A
----
P
-
E
V
A
E
-
R
K
A
E
L
N
D
V
Y
W
-----
S
I
--
D
Q
I
I
--
Y
G
Y
E
R
K
D
R
E
----------------------------------------------------------------------------
8
PsiBlast_PDB
74.64
22%
-6
- C2 -
-
3SG8
1
?
A:
[31-296]
-----------------------------------
G
N
D
C
I
-
A
Y
E
-
I
-------
N
R
D
F
I
F
-
K
F
P
K
H
---
S
R
G
--
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
-----------
P
-------
S
E
--
T
Y
Q
-----
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
-
L
N
N
L
--------
P
---
K
Q
S
Q
-
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
--
L
-
V
--
L
D
---------------
F
R
E
-
K
I
N
E
D
--
N
--
K
K
I
--
K
---------------
K
L
---
L
----
S
R
E
L
K
G
P
Q
M
K
K
V
D
D
----
F
Y
R
D
I
L
---
E
--
N
---
E
I
Y
F
K
-
Y
Y
P
-
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
--
K
----
N
----
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
---
M
E
D
DEE-
Y
----
G
-----
M
E
F
V
S
K
I
-
L
N
H
Y
K
H
K
--
D
--
I
-
P
T
V
L
-
E
K
Y
R
M
K
E
K
Y
W
-----
S
F
--
E
K
I
I
--
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
I
R
------------------------------------------------------------------
60
HHSearch
74.59
21%
-1
- C2 -
-
5IGH
-
?
A:
[8-297]
-----
D
T
S
Q
L
Y
A
L
A
A
R
H
G
L
--
K
--
L
H
-
G
P
L
T
V
N
E
L
G
L
D
Y
R
-
I
V
I
-
A
---
T
V
DD
G
R
R
W
V
L
-
R
I
P
R
R
---
A
-
E
V
-
S
A
K
V
E
P
E
A
R
V
L
A
M
L
K
N
R
--
L
P
F
A
V
P
D
W
R
V
A
N
A
-----------
E
L
V
A
Y
P
ML
E
D
--
S
T
A
-----
M
V
-----
I
Q
P
G
S
S
T
P
D
W
V
--
V
P
-------------
Q
D
S
E
-
V
F
A
E
S
-
F
A
T
A
L
A
A
L
H
A
V
P
I
S
A
A
V
D
A
--
G
M
L
I
R
T
P
--
T
Q
A
---
R
Q
K
----
V
A
D
-
D
V
D
R
V
--
R
--
R
E
F
------------------
V
----
V
----
N
D
K
R
L
-------
H
R
----
W
Q
R
W
L
D
---
D
--
D
---
S
-
S
W
P
-
D
F
S
-
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
--
D
--
N
T---
E
----
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
---
L
M
V
----
F
----
G
-----
E
E
G
L
A
K
L
-
L
L
T
Y
E
A
A
G
G
R
V
-
W
-
P
R
L
A
-
H
H
I
A
E
R
L
A
F
G
-----
A
V
--
T
Y
A
L
--
F
A
L
D
S
G
N
E
E
Y
L
A
A
A
K
A
Q
L
-------------------------------------------------------------------
61
HHSearch
74.20
21%
6
- C2 -
-
5IGI
3
?
A:
[8-297]
-----
D
T
S
Q
L
Y
A
L
A
A
R
H
G
L
--
K
--
L
H
-
G
P
L
T
V
N
E
L
G
L
D
Y
R
-
I
V
I
-
A
---
T
V
DD
G
R
R
W
V
L
-
R
I
P
R
R
---
A
-
E
V
-
S
A
K
V
E
P
E
A
R
V
L
A
M
L
K
N
R
--
L
P
F
A
V
P
D
W
R
V
A
N
A
-----------
E
L
V
A
Y
PML
E
D
--
S
T
A
------
V
-----
I
Q
P
G
S
S
T
P
D
W
V
--
V
P
-------------
Q
D
S
E
-
V
F
A
E
S
-
F
A
T
A
L
A
A
L
H
A
V
P
I
S
A
A
V
D
A
--
G
M
L
IR
T
P
--
T
Q
A
---
R
Q
K
----
V
A
D
-
D
V
D
R
V
--
R
--
R
E
F
------------------
V
----
V
----
N
D
K
R
L
-------
H
R
----
W
Q
R
W
L
D
---
D
--
D
---
S
-
S
W
P
-
D
F
S
-
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
--
D
--
N
T---
E
----
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
---
L
M
V
----
F
----
G
-----
E
E
G
L
A
K
L
-
L
L
T
Y
E
A
A
G
G
R
V
-
W
-
P
R
L
A
-
H
H
I
A
E
R
L
A
F
G
-----
A
V
--
T
Y
A
L
--
F
A
L
D
S
G
N
E
E
Y
L
A
A
A
K
A
Q
L
-------------------------------------------------------------------
5
PsiBlast_PDB
74.05
22%
-3
- C2 -
-
3SG9
1
?
A:
[31-296]
-----------------------------------
G
N
D
C
I
-
A
Y
E
-
I
-------
N
R
D
F
I
F
-
K
F
P
K
H
---
S
R
G
--
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
-----------
P
-------
S
E
--
T
Y
Q
-----
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
-
L
N
N
L
--------
P
---
K
Q
S
Q
-
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
--
L
-
V
--
L
D
---------------
F
R
E
-
K
I
N
E
D
--
N
--
K
K
I
--
K
---------------
K
L
---
L
----
S
R
E
L
K
G
P
Q
M
K
K
V
D
D
----
F
Y
R
D
I
L
---
E
--
N
---
E
I
Y
F
K
-
Y
Y
P
-
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
--
K
----
N
----
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
---
M
E
D
DEE-
Y
----
G
-----
M
E
F
V
S
K
I
-
L
N
H
Y
K
H
K
--
D
--
I
-
P
T
V
L
-
E
K
Y
R
M
K
E
K
Y
W
-----
S
F
--
E
K
I
I
--
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
I
R
------------------------------------------------------------------
7
PsiBlast_PDB
73.98
22%
-8
- C- -
-
3N4U
-
?
A:
[31-296]
-----------------------------------
G
N
D
C
I
-
A
Y
E
-
I
-------
N
R
D
F
I
F
-
K
F
P
K
H
---
S
R
G
--
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
-----------
P
-------
S
E
--
T
Y
Q
-----
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
-
L
N
N
L
--------
P
---
K
Q
S
Q
-
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
--
L
-
V
--
L
D
---------------
F
R
E
-
K
I
N
E
D
--
N
--
K
K
I
--
K
---------------
K
L
---
L
----
S
R
E
L
K
G
P
Q
M
K
K
V
D
D
----
F
Y
R
D
I
L
---
E
--
N
---
E
I
Y
F
K
-
Y
Y
P
-
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
--
K
----
N
----
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
---
M
E
D
DEE-
Y
----
G
-----
M
E
F
V
S
K
I
-
L
N
H
Y
K
H
K
--
D
--
I
-
P
T
V
L
-
E
K
Y
R
M
K
E
K
Y
W
-----
S
F
--
E
K
I
I
--
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
I
R
------------------------------------------------------------------
10
PsiBlast_PDB
73.89
22%
-5
- C2 -
-
6CD7
-
?
A:
[32-297]
-----------------------------------
G
N
D
C
I
-
A
Y
E
-
I
---
N
----
R
D
F
I
F
-
K
F
P
K
H
---
S
R
G
--
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
-----------
P
-------
S
E
--
T
Y
Q
-----
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
-
L
N
N
L
--------
P
---
K
Q
S
Q
-
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
--
L
-
V
--
L
D
---------------
F
R
E
-
K
I
N
E
D
--
N
--
K
K
I
--
K
---------------
K
L
---
L
----
S
R
E
L
K
G
P
Q
M
K
K
V
D
D
----
F
Y
R
D
I
L
---
E
--
N
---
E
I
Y
F
K
-
Y
Y
P
-
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
--
K
----
N
----
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
---
M
E
D
DEE-
Y
----
G
-----
M
E
F
V
S
K
I
-
L
N
H
Y
K
H
K
--
D
--
I
-
P
T
V
L
-
E
K
Y
R
M
K
E
K
Y
W
-----
S
F
--
E
K
I
I
--
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
I
R
------------------------------------------------------------------
14
PsiBlast_PDB
73.44
22%
-1
- C2 -
-
4DTA
1
?
A:
[31-296]
-----------------------------------
G
N
D
C
I
-
A
Y
E
-
I
-------
N
R
D
F
I
F
-
K
F
P
K
H
---
S
R
G
--
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
-----------
P
-------
S
E
--
T
Y
Q
-----
M
S
F
A
G
M
T
K
I
K
G
V
P
L
T
P
L
L
-
L
N
N
L
--------
P
---
K
Q
S
Q
-
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
--
L
-
V
--
L
D
---------------
F
R
E
-
K
I
N
E
D
--
N
--
K
K
I
--
K
---------------
K
L
---
L
----
S
R
E
L
K
G
P
Q
M
K
K
V
D
D
----
F
Y
R
D
I
L
---
E
--
N
---
E
I
Y
F
K
-
Y
Y
P
-
C
L
I
H
N
D
F
S
S
D
H
I
L
F
--
D
TE
K
----
N
----
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
---
M
E
D
DEE-
Y
----
G
-----
M
E
F
V
S
K
I
-
L
N
H
Y
K
H
K
--
D
--
I
-
P
T
V
L
-
E
K
Y
R
M
K
E
K
Y
W
-----
S
F
--
E
K
I
I
--
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
I
R
------------------------------------------------------------------
12
PsiBlast_PDB
73.37
22%
1
- C2 -
-
4DT8
1
?
A:
[31-296]
-----------------------------------
G
N
D
C
I
-
A
Y
E
-
I
-------
N
R
D
F
I
F
-
K
F
P
K
H
---
S
R
G
--
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
-----------
P
-------
S
E
--
T
Y
Q
-----
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
-
L
N
N
L
--------
P
---
K
Q
S
Q
-
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
--
L
-
V
--
L
D
---------------
F
R
E
-
K
I
N
E
D
--
N
--
K
K
I
--
K
---------------
K
L
---
L
----
S
R
E
L
K
G
P
Q
M
K
K
V
D
D
----
F
Y
R
D
I
L
---
E
--
N
---
E
I
Y
F
K
-
Y
Y
P
-
C
L
I
H
N
D
F
S
S
D
H
I
L
F
--
D
TE
K
----
N
----
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
---
M
E
D
DEE-
Y
----
G
-----
M
E
F
V
S
K
I
-
L
N
H
Y
K
H
K
--
D
--
I
-
P
T
V
L
-
E
K
Y
R
M
K
E
K
Y
W
-----
S
F
--
E
K
I
I
--
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
I
R
------------------------------------------------------------------
13
PsiBlast_PDB
72.94
22%
-3
- C2 -
-
4DT9
1
?
A:
[31-296]
-----------------------------------
G
N
D
C
I
-
A
Y
E
-
I
-------
N
R
D
F
I
F
-
K
F
P
K
H
---
S
R
G
--
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
-----------
P
-------
S
E
--
T
Y
Q
-----
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
-
L
N
N
L
--------
P
---
K
Q
S
Q
-
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
--
L
-
V
--
L
D
---------------
F
R
E
-
K
I
N
E
D
--
N
--
K
K
I
--
K
---------------
K
L
---
L
----
S
R
E
L
K
G
P
Q
M
K
K
V
D
D
----
F
Y
R
D
I
L
---
E
--
N
---
E
I
Y
F
K
-
Y
Y
P
-
C
L
I
H
N
D
F
S
S
D
H
I
L
F
--
D
TE
K
----
N
----
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
---
M
E
D
DEE-
Y
----
G
-----
M
E
F
V
S
K
I
-
L
N
H
Y
K
H
K
--
D
--
I
-
P
T
V
L
-
E
K
Y
R
M
K
E
K
Y
W
-----
S
F
--
E
K
I
I
--
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
I
R
------------------------------------------------------------------
2
PsiBlast_PDB
72.86
22%
-0
- C2 -
-
4N57
1
?
A:
[51-316]
-----------------------------------
G
N
D
C
I
-
A
Y
E
-
I
---
N
----
R
D
F
I
F
-
K
F
P
K
H
---
S
R
G
--
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
-----------
P
-------
S
E
--
T
Y
Q
-----
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
-
L
N
N
L
--------
P
---
K
Q
S
Q
-
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
--
L
-
V
--
L
D
---------------
F
R
E
-
K
I
N
E
D
--
N
--
K
K
I
--
K
---------------
K
L
---
L
----
S
R
E
L
K
G
P
Q
M
K
K
V
D
D
----
F
Y
R
D
I
L
---
E
--
N
---
E
I
Y
F
K
-
Y
Y
P
-
C
L
I
H
N
D
F
S
S
D
H
I
L
F
--
D
TE
K
----
N
----
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
---
M
E
D
DEE-
Y
----
G
-----
M
E
F
V
S
K
I
-
L
N
H
Y
K
H
K
--
D
--
I
-
P
T
V
L
-
E
K
Y
R
M
K
E
K
Y
W
-----
S
F
--
E
K
I
I
--
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
I
R
------------------------------------------------------------------
11
PsiBlast_PDB
72.68
22%
-3
- C2 -
-
4DTB
1
?
A:
[31-296]
-----------------------------------
G
N
D
C
I
-
A
Y
E
-
I
-------
N
R
D
F
I
F
-
K
F
P
K
H
---
S
R
G
--
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
-----------
P
-------
S
E
--
T
Y
Q
-----
M
S
F
A
G
Y
T
K
I
K
G
V
P
L
T
P
L
L
-
L
N
N
L
--------
P
---
K
Q
S
Q
-
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
--
L
-
V
--
L
D
---------------
F
R
E
-
K
I
N
E
D
--
N
--
K
K
I
--
K
---------------
K
L
---
L
----
S
R
E
L
K
G
P
Q
M
K
K
V
D
D
----
F
Y
R
D
I
L
---
E
--
N
---
E
I
Y
F
K
-
Y
Y
P
-
C
L
I
H
N
D
F
S
S
D
H
I
L
F
--
D
TE
K
----
N
----
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
---
M
E
D
DEE-
Y
----
G
-----
M
E
F
V
S
K
I
-
L
N
H
Y
K
H
K
--
D
--
I
-
P
T
V
L
-
E
K
Y
R
M
K
E
K
Y
W
-----
S
F
--
E
K
I
I
--
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
I
R
------------------------------------------------------------------
18
PsiBlast_PDB
72.18
22%
5
- C2 -
-
4DFU
3
?
A:
[52-317]
-----------------------------------
G
N
D
C
I
-
A
Y
E
-
I
---
N
----
R
D
F
I
F
-
K
F
P
K
H
---
S
R
G
--
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
-----------
P
-------
S
E
--
T
Y
Q
MS
F
A
G
F
T
-----
K
I
K
G
V
P
L
T
P
L
L
-
L
N
N
L
--------
P
---
K
Q
S
Q
-
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
--
L
-
V
--
L
D
---------------
F
R
E
-
K
I
N
E
D
--
N
--
K
K
I
--
K
---------------
K
L
---
L
----
S
R
E
L
K
G
P
Q
M
K
K
V
D
D
----
F
Y
R
D
I
L
---
E
--
N
---
E
I
Y
F
K
-
Y
Y
P
-
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
--
K
----
N
----
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
M
ED
D
E
E
----
Y
----
G
-----
M
E
F
V
S
K
I
-
L
N
H
Y
K
H
K
--
D
--
I
-
P
T
V
L
-
E
K
Y
R
M
K
E
K
Y
W
-----
S
F
--
E
K
I
I
--
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
I
R
------------------------------------------------------------------
16
PsiBlast_PDB
72.18
22%
2
- C2 -
-
4DE4
1
?
A:
[52-317]
-----------------------------------
G
N
D
C
I
-
A
Y
E
-
I
---
N
----
R
D
F
I
F
-
K
F
P
K
H
---
S
R
G
--
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
-----------
P
-------
S
E
--
T
Y
Q
MS
F
A
G
F
T
-----
K
I
K
G
V
P
L
T
P
L
L
-
L
N
N
L
--------
P
---
K
Q
S
Q
-
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
--
L
-
V
--
L
D
---------------
F
R
E
-
K
I
N
E
D
--
N
--
K
K
I
--
K
---------------
K
L
---
L
----
S
R
E
L
K
G
P
Q
M
K
K
V
D
D
----
F
Y
R
D
I
L
---
E
--
N
---
E
I
Y
F
K
-
Y
Y
P
-
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
--
K
----
N
----
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
MED
D
E
E
----
Y
----
G
-----
M
E
F
V
S
K
I
-
L
N
H
Y
K
H
K
--
D
--
I
-
P
T
V
L
-
E
K
Y
R
M
K
E
K
Y
W
-----
S
F
--
E
K
I
I
--
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
I
R
------------------------------------------------------------------
17
PsiBlast_PDB
71.48
22%
14
- C2 -
-
4DFB
1
?
A:
[52-317]
-----------------------------------
G
N
D
C
I
-
A
Y
E
-
I
---
N
----
R
D
F
I
F
-
K
F
P
K
H
---
S
R
G
--
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
-----------
P
-------
S
E
--
T
Y
Q
MS
F
A
G
F
T
-----
K
I
K
G
V
P
L
T
P
L
L
-
L
N
N
L
--------
P
---
K
Q
S
Q
-
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
--
L
-
V
--
L
D
---------------
F
R
E
-
K
I
N
E
D
--
N
--
K
K
I
--
K
---------------
K
L
---
L
----
S
R
E
L
K
G
P
Q
M
K
K
V
D
D
----
F
Y
R
D
I
L
---
E
--
N
---
E
I
Y
F
K
-
Y
Y
P
-
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
--
K
----
N
----
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
M
E--
E
E
----
Y
----
G
-----
M
E
F
V
S
K
I
-
L
N
H
Y
K
H
K
--
D
--
I
-
P
T
V
L
-
E
K
Y
R
M
K
E
K
Y
W
-----
S
F
--
E
K
I
I
--
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
I
R
------------------------------------------------------------------
64
HHSearch
70.88
19%
21
- C2 -
-
5IWU
2
?
A:
[4-298]
-----
D
I
K
Q
V
I
E
I
A
K
K
H
N
L
FL
K
--
E
--
E
T
I
Q
F
N
E
S
G
L
D
F
Q
-
A
V
F
-
A
---
Q
D
NN
G
I
D
W
V
L
-
R
L
P
R
R
---
E
-
D
V
-
M
P
R
T
K
V
E
K
Q
A
L
D
L
V
N
K
Y
A-
I
S
F
Q
A
P
N
W
I
I
Y
T
--------------------
E
E
--
L
I
A
-----
Y
K
-----
K
L
D
G
V
P
A
G
T
I
D
--
H
N
I
GNYIWEID
I
N--
N
V
P
E
-
L
F
H
K
S
-
L
G
R
V
L
A
E
L
H
S
I
P
S
N
K
A
A
A
L
--
D
L
V
V
H
T
P
--
E
E
A
---
R
M
S
----
M
K
Q
-
R
M
D
A
V
--
R
--
A
K
---
F
---------------
G
V
--------
G
E
N
L
W
-------
N
R
----
W
Q
A
W
L
N
---
D
--
D
---
D
-
M
W
P
-
K
K
T
-
G
L
I
H
G
D
V
H
A
G
H
T
M
I
--
D
--
K
D---
A
----
N
V
T
G
L
I
D
W
T
E
A
K
V
T
D
V
S
H
D
F
I
F
N
---
Y
R
A
----
F
----
G
-----
E
E
G
L
E
A
L
-
I
L
A
Y
K
E
I
G
G
Y
--
Y
W
P
K
M
K
-
E
H
I
I
E
L
N
A
A
Y
-----
P
V
--
S
I
A
E
--
F
A
L
V
S
G
I
E
E
Y
E
Q
M
A
K
E
A
L
E
------------------------------------------------------------------
31
Fugue
70.51
16%
-13
- C2 -
-
3HAM
3
?
A:
[1-299]
---
M
V
N
L
D
A
E
I
Y
E
H
L
N
K
Q
I
--
K
--
I
--
N
E
L
R
Y
L
S
S
G
D
D
S
D
-
T
F
L
-
C
---
N
---
E
Q
Y
V
V
K
-
V
P
K
R
D
---
S
-
V
--
R
I
S
Q
K
R
E
F
E
L
Y
R
F
L
E
N
C
---
K
L
S
Y
Q
I
P
A
V
V
Y
Q
-----------
S
-------
D
R
--
F
N
I
-----
M
K
-----
Y
I
K
G
E
R
I
T
Y
E
Q
Y
H
K
L
S
--------
E
---
K
E
K
D
-
A
L
A
Y
D
-
E
A
T
F
L
K
E
L
H
S
I
E
I
D
C
S
V
S
L
--
F
-
S
--
D
A
--
L
V
N
---
K
K
D
----
K
F
L
-
Q
D
K
K
L
--
L
--
I
S
I
--
L
---------------
E
K
E
QL
L
----
T
D
E
M
L
-------
E
H
----
I
E
T
I
Y
E
---
N
--
I
L
N
N
A
V
L
F
K
-
Y
T
P
-
C
L
V
H
N
D
F
S
A
N
N
M
I
F
--
R
--
N
----
N
----
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
L
---
L
D
C
----
S
----
T
-----
D
D
F
G
K
E
F
-
G
R
K
V
L
K
Y
Y
Q
H
KA
P
-
E
V
A
E
-
R
K
A
E
L
N
D
V
Y
W
-----
S
I
--
D
Q
I
I
--
Y
G
Y
E
R
K
D
R
E
M
L
I
K
G
V
S
E
L
L
Q
T
Q
A
E
M
F
IF---------------------------------------------------------
56
HHSearch
70.15
17%
-14
- C2 -
-
3TDW
1
?
A:
[10-298]
----------
T
M
I
M
T
Q
F
P
D
I-
S
--
I
--
Q
S
V
E
S
L
G
E
G
F
R
N
Y
-
A
I
L
-
V
---
N
---
G
D
W
-
V
F
-
R
F
P
K
S
---
Q
-
Q
G
-
A
D
E
L
N
K
E
I
Q
L
L
P
L
L
V
G
C
--
V
K
V
N
I
P
Q
Y
V
Y
I
G
K
R
SD--------
G
-------
N
P
--
F
V
G
-----
Y
R
-----
K
V
Q
G
Q
I
L
G
E
D
G
--
M
A
V
--------
L
P
D
-
D
A
K
D
-
R
L
A
L
Q
-
L
A
E
F
M
N
E
L
S
A
F
P
V
E
T
A
I
S
A
--
G
-
V
--
P
V
--
T
N
L
---
K
N
K
----
I
L
L
-
L
S
E
A
V
--
E
--
D
Q
V
--
F
---------------
P
L
---
L
----
D
E
S
L
R
-------
D
Y
L
T
L
R
F
Q
S
Y
M
T
------
H
---
P
V
Y
T
R
-
Y
T
P
-
R
L
I
H
G
D
L
S
P
D
H
F
L
T
--
N
--
L
NSRQ
T
----
P
L
T
G
I
I
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
V
Y
L
---
L
E
D
----
C
----
G
-----
E
L
F
-
T
R
Q
-
V
M
A
Y
R
G
E
V
D
---
L
-
D
T
H
I
-
R
K
V
S
L
F
V
T
F
D
-----
Q
V
--
S
Y
L
L
--
E
G
L
R
A
R
D
Q
D
W
I
S
E
G
L
E
L
L
E
E
D
K
A
--------------------------------------------------------------
62
HHSearch
68.00
16%
-0
* C2 *
-
5IQC
2
AACA_STAAU
A:
[26-303]
------------------
F
--
K
--
V
--
D
S
I
E
I
I
G
S
G
Y
D
S
V
-
A
Y
L
-
V
---
N
---
N
E
Y
-
I
F
-
K
T
K
F
S
---
T
-
N
K-
K
K
G
Y
A
K
E
K
A
I
Y
N
F
L
N
T
N
LE
T
N
V
K
I
P
N
I
E
Y
S
Y
I
-----------
S
DE-----
L
S
--
I
L
G
-----
Y
K
-----
E
I
K
G
T
F
L
T
P
E
I
--
Y
S
T
--------
M
S
E
-
E
E
Q
N
-
L
L
K
R
D
-
I
A
S
F
L
R
Q
M
H
G
L
D
Y
T
D
I
S
E
C
--
T
I
D
--
N
K
--
Q
N
V
---
L
E
E
----
Y
I
L
-
L
R
E
T
I
----------
Y
---------------
N
D
---
L
----
T
D
I
E
K
-------
D
Y
----
I
E
S
F
M
E
---
R
L
N
A
---
T
T
V
F
E
-
G
K
K
-
C
L
C
H
N
D
F
S
C
N
H
L
L
L
--
D
--
G
N---
N
----
R
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
I
Y
L
---
L
E
D
SEEE
I
----
G
-----
T
N
F
G
E
D
I
-
L
R
M
Y
G
N
I
--
D
--
I
-
E
K
A
K
-
E
Y
Q
D
I
V
E
E
Y
Y
-----
P
I
--
E
T
I
V
--
Y
G
I
K
N
I
K
Q
E
F
I
E
N
G
R
K
E
I
Y
K
R
T
Y
--------------------------------------------------------------
36
Fugue
64.01
19%
0
- C2 -
-
3CSV
11
?
A:
[4-333]
-------
S
R
E
D
E
I
R
D
F
L
A
T
--
H
--
G
--
Y
A
D
W
N
R
T
P
R
Y
Q
R
L
-
R
S
P
-----
T
---
G
A
K
A
V
L
M
D
W
S
P
E
---
E
-
G
--
G
-
D
T
Q
P
F
V
D
L
A
Q
Y
L
R
N
L
---
D
I
S
A
P
E
I
Y
A
E
E
H
-----------
A
-------
R
G
--
L
L
L
-----
I
E
-----
D
L
G
D
A
L
F
T
E
V
I
-
N
N
D
P
--------
A
---
Q
--
E
M
P
L
Y
R
A
-
A
V
D
L
L
I
H
L
H
D
------
A
Q
T
--
P
-
E
--
L
A
--
R
L
D
---
P
E
T
----
L
S
E
M
T
R
L
A
F
--
S
--
E
Y
R
--
Y
---------------
A
I
LGD
A
----
A
E
D
N
R
-------
K
R
----
F
E
H
R
F
A
---
Q
--
I
---
L
S
A
Q
L
-
E
G
D
M
V
F
V
H
R
D
F
H
A
Q
N
L
L
W
--
L
--
P
----
E
REGL
A
R
V
G
V
I
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
V
S
L
---
L
Q
D
----
A
----
R
RDV--
P
A
Q
V
E
A
Q
M
I
D
H
Y
I
Q
A
T
G
V
--
D
-
E
S
H
F
-
R
S
A
Y
A
V
I
A
V
Q
R
N
M
R
I
L
G
--
I
F
A
R
--
L
S
Q
R
F
G
K
R
H
Y
I
E
F
V
P
R
V
W
A
H
F
E
R
G
L
A
HPALASA
A
E
E
I
L
N
A
L
PAPA
P
E
V
L
E
R
L
R
A-------------------------------
68
HHSearch
61.62
20%
-16
- C2 -
-
3CSV
9
?
A:
[5-277]
-----
R
E
D
E
I
R
D
F
L
A
T
H
G
Y
--
A
--
D
--
W
N
R
T
P
---------
R
Y
Q
R
L
---
R
S
PT
G
A
K
A
V
L
-
M
D
W
S
P
---
E
-
E
--
G
G
D
T
Q
P
F
V
D
L
A
Q
Y
L
R
N
---
L
D
I
S
A
P
E
I
Y
A
E
E
H
-----------
A
-------
R
G
--
L
L
L
-----
I
E
-----
D
L
G
D
A
L
F
T
E
V
I
--
N
N
D
--------
P
---
A
Q
E
M
-
P
L
Y
R
A
-
A
V
D
L
L
I
H
L
H
D
A
Q
T
P
E
L
A
R
L
--
D
-
P
------
E
T
L
---
S
E
M
T
RLA
F
S
E
-
Y
R
Y
A
I
--
L
--
G
D
A
--
A
---------------
E
D
---
N
----
R
K
R
F
E
-------
H
R
----
F
A
Q
I
L
S
---
A
--------
Q
L
E
-
G
D
M
-
V
F
V
H
R
D
F
H
A
Q
N
L
L
W
--
L
--
P
----
E
REGL
A
R
V
G
V
I
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
V
S
L
---
L
Q
D
----
A
RRDV
P
-----
A
Q
V
E
A
Q
M
-
I
D
H
Y
I
Q
A
T
G
V
--
D
-
E
S
H
F
R
S
A
Y
A
V
I
A
V
Q
R
-----
N
M
--
R
I
L
G
--
I
F
-----------------------------------------------------------------------------------
71
HHSearch
59.90
18%
-12
- C2 -
-
6EF6
2
?
A:
[29-318]
-------
T
I
A
Q
Q
A
L
T
H
Y
D
V
--
S
D-
N
--
A
S
L
R
L
L
-
N
L
S
E
N
A
-
T
Y
L
-
V
---
E
D
GE
H
Q
S
-
I
L
-
R
V
H
R
Q
---
D
-
Y
HQ
P
H
E
I
E
S
E
L
D
W
L
A
A
L
R
T
D
--
S
D
V
T
V
P
T
V
V
P
A
R
D
GRR
V
V
T
V
D
P
A
D
V
P
------
R
H
--
V
V
H
-----
F
E
-----
M
V
G
G
A
E
P
D
E
E
S
--
L
----------------
T
L
-
D
D
F
Q
T
-
L
G
R
I
T
A
S
L
H
E
H
S
Q
R
W
T
R
P
A
G
F
G
-
R
F
-
S
W
DW
E
H
C
LGD
T
P
R
----
W
G
R
-
W
Q
D
A
E
--
G
VG
A
S
E
--
T
---------------
A
L
---
L
----
T
-
R
A
Q
-------
D
L
----
L
H
R
K
L
E
---
E
--
Y
---
G
-
S
G
P
-
D
R
Y
-
G
L
I
H
A
D
L
R
L
A
N
L
L
V
--
D
--
S
----
S
TPQ-
R
T
I
T
V
I
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
G
T
A
---
V
S
F
----
I
----
E
HDPR
L
G
E
W
Q
E
S
W
-
V
A
G
Y
R
S
R
R
E
L
--
P
-
A
A
D
E
-
A
M
L
P
S
F
V
F
L
R
-----
R
L
--
L
L
L
A
--
W
M
-----------------------------------------------------------------------------------
35
Fugue
58.66
15%
13
- C2 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
KTP
L
Y
E
T
L
N
E
S
S
A
V
A
L
A
V
K
--
L
--
G
LT
L
T
C
Q
E
I
G
D
G
N
L
N
Y
-
V
F
H
-
I
---
Y
---
D
R
A
L
I
I
-
K
Q
A
V
P
YWP
L
-
T
--
I
D
R
A
R
I
E
S
S
A
L
I
R
Q
G
E
H
--
V
P
H
L
V
P
R
V
F
Y
S
D
T
-----------
E
-------
M
A
--
V
T
V
-----
M
E
-----
D
L
S
H
L
K
I
A
R
K
G
-
L
I
E
G
--------
E
NYP
H
L
S
Q
-
H
I
G
E
F
-
L
G
K
T
L
F
Y
S
S
D
Y
A
L
E
P
K
V
K
K
--
Q
-
L
--
V
K
--
Q
F
T
---
N
P
E
----
L
C
D
-
I
T
E
R
L
--
V
--
F
T
D
--
P
FFDHDT
N
D
F
E
EEL
R
P
F
V
---
E
----
K
L
W
N
N
-------
D
S
----
V
K
I
E
A
A
---
K
--
L
---
K
K
S
F
L
T
S
A
E
-
T
L
I
H
G
D
L
H
T
G
S
I
F
A
--
S
--
E
----
H
----
E
-
T
K
V
I
D
P
E
F
A
F
Y
G
P
I
G
F
D
V
G
Q
F
---
I
A
N
----
L
----
F
-----
L
N
A
L
S
R
D
-
G
A
D
R
E
P
L
Y
E
H
--
V
-
N
Q
V
W
-
E
T
F
E
E
T
F
S
E
A
-----
W
Q
--
K
D
S
L
DV
Y
A
N
I
D
G
Y
L
T
D
T
L
S
H
I
F
E
E
A
I
G
F
A
G
C
E
L
I
R
R
T
IGLAHV
A
D
L
D
T
IVP
F
D
K
R
I
G
R
K
R
L
A
L
E
T
G
T
A
F
I
E
KRSEFKT
I
T
D
V
I
E
L
F
K
L
L
V
K
46
SP3
52.24
16%
6
- C2 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
----
G
S
P
--
A
A
W
V
E
R
L
F
G
---------
Y
D
W
A
Q
Q
T
I
G
C
S
D
A
A
V
F
R
-
L
S
A
Q
G
---
R
P
V
L
F
V
-
K
T
D
L
S
---
G
-
A
--
L
N
E
L
Q
D
E
A
A
R
L
S
W
L
A
T
T
---
G
V
P
C
A
A
V
L
D
V
V
T
-----------
E
-------
A
G
R
D
W
L
L
-----
L
G
-----
E
V
P
G
Q
D
L
L
S
S
H
-
L
A
----------------
P
A
-
E
K
V
S
I
-
M
A
D
A
M
R
R
L
H
T
L
D
P
A
T
C
P
F
D
--
H
-
Q
--
A
K
--
H
R
I
---
E
R
A
----
R
T
R
-
M
E
A
G
L
VD
Q
--
D
D
L
--
D
---------------
E
E
---
H
----
Q
G
L
A
P
-------
A
E
----
L
F
A
R
L
K
---
A
--
R
---
M
P
-
D
G
-
E
D
L
-
V
V
T
H
G
D
A
C
L
P
N
I
M
V
--
E
--
N
----
G
----
R
F
S
G
F
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
---
T
R
D
----
I
----
A
-----
E
E
L
G
G
E
W
-
A
D
R
F
L
V
L
Y
G
I
--
A
-
A
P
D
S
-
Q
R
I
A
F
Y
R
L
L
D
-----
E
F
--
F
------------------------------------------------------------------------------------------