@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : D4DJP3_TRIVH: (2019-01-27 )
MEEALARHDRFGEDFSKVFTIINSAEIPAVENSALYLFVGTSRAPDEASKYVRDRVAQNAQSSTLEETLHSIHEELKILSKKMTREDPMNLDPEIEAALYERDGGCCFITGRTAGVQPIYIIPPSILEDKDLQPGGYLRPLLEVSLTKEGTEQMLNLLGLPGRENVLKNLILMEPSIRYSFRHGYFEIIKSPYLEPPYLPTDAPKSKNGGWWLQPIAPQSEVPQIIPRNNELYKVPSTINPISHPLPARLLLKTHGIVSHPLHTIYIEEQIKAGWPVEPEPKELNWVGRLLLQILLRLIPNFARIRLYELIYKMVDYWDPSQKGSHVKFLPLGLVLKKGRENTENEAKALTLAEQYISISTPRLIDSVMVNKTSGFILMTKVVGRSLSSILHRITWEELEQIGKDLANFITELRRIPNSSKYLIADTRGGPISDHRFFYQTWGPFKTVSGFTDRLLQDVKGARDKPPLSFLYEKKHKVYFTHSDIHMTNLFVTCGRLSGVVDWENAGFKPEYWEYIRAMWAYGADKHAKCLYGSAFGDKYKEEGGIEITAVWIGFSLTTFSGFSGLIFEQLIRLRNEYLPLAQGKISPDVNPGHLCSTAKTSYTSAFARWEAVPARPMPTSQSGPITAKDAFKG
Atome Classification :
(26 SA)
--------------------------------------------------.......--------..10......---..20........30--------.-----.......----40..-......50....-----...-.60---.--.......70--------------...----.---..----------.----..-----80-------..----.--.....90..-.......----100.-----.-.------...---.110-------------.-----......--.120----------.--...---------...130-........140....-.-..150-------..------------.....-----------..160.......------------------------..170--......--...-180.------..----..-----------..---190.....--------..200--------.........210-........220---------------------...-------.....230-------------------------......------..240....---------------------------...250.--..------..----..260--------------------....--------------------...270.----.------...---------------------------------------------------------.----.280.......290.......300-.---..----------..-...310----------..-----------.-------------..--...320....----------...330-----.......340..---.....350----....---...360.-.----...---.--.370-.....----...--------380....-...-390------..---------..--------.---------....400.---------------------......410...-....420..-.-....430.--------.....-.440.....-..-450...----..--------.-.------460........-470---.----------....------.-------.-------480.-----.--------.....490-----------------..-.----...-----..500....---...510....----...520.......530--------.........540.......550.-...-------...560------.......570....---------...580.....--..590.......600......---.610.-----..-----....620......------..630..-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------------------------------------
M
E
E
A
L
A
R
--------H
D
R
F
G
E
D
F
S
K
---
V
F
T
I
I
NSAEIPAVE--------N-----S
A
L
Y
L
F
V----GTSR-A
P
D
E
A
S
K
Y
V
R
D
R
-----
V
A
Q-NA
Q
---
S
--
S
T
L
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H
---------------
S
I
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----
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---
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L
----------
K
----
I
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-----
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K
M----T--REDPMN-LD-PE
I
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----YERD-----G-
G
------
C
C
F
---ITG--------------R-----TAGV
Q
P
--
I
Y
I
I----------P--PSI---------LEDKD--LQPGG
Y
L
R
P
L
L
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VSL-T-
K
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G
---------
T
E
------------
Q
M
L
N
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-----------LGL--P
G
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N
V
L
------------------------
K
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----ILMEPS--
I
R
Y
-
S
F
R
H
------
G
Y
----
F
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-----------
I
I
---KSPYLEPP--------YLP----------TDAPKSKNG
G
W
--
W
L
QPIAPQSE----------------------VPQ-------IIPRNN
E
--------------------------
L
Y
KVPS------TINPISHPL---------------------------
P
A
R
L
L
L
K
--TH------GI----VSHP
L
--------------------
H
T
I
Y
--------------------
I
E
E
QIKA----G------WPV---------------------------------------------------------E----PEP
K
E
L
N
W
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L
L
Q
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LIP
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--
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-------------
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D--YWDPSQKGS
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----------
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-----
G
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KKGRENTE---
N
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----
A
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T
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R-IPNSS
K
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A
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R
F
F
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Y
QTWGPFKT-V
S
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G
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----
L
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--------
D
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V
------K-GARDKP
P
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F
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K
------
V
-------
Y
-------
F
THS-----D--------
I
H
M
T
N
L
F
------------------
V
T
-C----GRL-----SGVVDWENA---GFK
P
E
Y
W
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Y
I
----
R
A
M
W
AYGADKH
A
K
C
----------
L
YGSAFGDKYKEEG
G
I
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I
T
A
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W
I
-
G
F
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-------
L
TTFSG------
F
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---------EYLPLAQGKIS--PDVNPGHLCSTAK
T
S
Y
T
S
A
F
A---RWEAV-----PA-----RPMPT-SQSGPIT------AKDAFKG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
61.30
20%
33
- C9 -
-
5LB8
-
RECQ5_HUMAN
D:
[4-444]
----------------------------------------------PERR
V
R
S
T
L
K
K
----------
V
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---
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Q
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A
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--------
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----
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A
-----------------------------------------------------------------------------------------------------------------------------
P
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--------------------------------------
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Q
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--------------------------------------------------------------------------
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---
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A
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-----------------------------
W
N
----
I
A
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Y
Y
Q
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G
R
-----------
A
-
G
R
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G
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P
-
S
--------
W
C
R
L
Y
-
Y
S
-------------------------------------------
R
N
D
R
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Q
V
S
-
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---
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----------
K
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V
A
------
K
-------
L
-------
Q
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K
R
---------------------------------------------------------------------------------------------------------------
G
N
K
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K
A
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M
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V
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C
R
H
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A
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---
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L
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A
L
-----
E
R
-----
S
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
57.81
16%
19
- C3 -
-
4CKB
1
MCEL_VACCW
A:
[1-844]
------------------------------MDANVVSSST
I
A
T
Y
I
D
A
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A
K
N
A
S
E
L
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--------
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N
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---
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-----
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-------
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----
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L
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---
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A
--------------
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T
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--
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F
K
L
----------
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--
Y
F
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GSGAQSKS
S
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L
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A
I
--
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R
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---------
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-----------
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--
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KQDIVGLDL
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----
Y
A
V
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-
T
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TSNGL
Y
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Y
----
F
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HLG
Y
-------
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I
---
R
Y
P
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K
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----
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K
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---
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-----------
M
SSEPIIFGES
S
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Y
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----------
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K
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---------
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------------------
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----
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W
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F
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P
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----
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G
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----------
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M
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CEGLD
V
E
D
L
L
S
Y
Y
V
V
Y
V
F
S
KR--------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
53.45
15%
15
- C6 -
-
4TUU
-
PK3CA_HUMAN
A:
[107-1046]
--------------------------------------------------
N
R
E
E
K
I
L
--------
N
R
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I
G
F
A
I
G
M
P
V
C
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K
D
P
E
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Q
D
F
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--------
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-----
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----
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A
V
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-
L
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P
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---
V
--
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P
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---------------
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I
Y
----
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---
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------
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Y
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--------------
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----------
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-----------
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R
------------------------
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L
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G
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L
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----
W
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R
--------------------
E
A
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E
N
D
K
E
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L
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A
----
I
S
T
RDPL
S
E
I
---------------------------------------------------------
T
----
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
T
I
P
E
I
L
P
K
--
L
---
L
L
S
VKWNS
R
D
E
V
A
Q
-
M
Y
C
L
V
K
D
WPPIK
P
E
Q
A
M
E
-----------
L
-------------
L
D
CN
Y
P
D
P
M
V
R
G
F
A
----------
V
R
C
L
E
K
-----
Y
L
T
D
D
K
L
S
Q
Y
L
I
---
Q
L
V
Q
V
L
K
Y
----
E
Q
Y
L
---
D
N
L
L
V
R
F
-
L
----
L
K
K
---
A
--
L
T
N
--
Q
R
I
G
H
----
F
F
F
W
H
L
K
S
E
M
H
N
K
T
V
S
Q
R
-
F
G
L
-
L
--------
L
E
---------
S
Y
--------
C
R
A
CGM
Y
L
K
H
L
N
R
Q
V
E
A
M
---------------------
E
K
L
I
N
L
T
D
I
L
K
Q
-
E
K
K
D
E
T
Q
K
V
-
Q
-
M
K
F
L
V
E
Q
M
--------
R
R
P
D
F
-
M
D
A
L
Q
G
F
L
S
-
P
L
-
N
P
A
H
Q
L
G
N
LR
L
E
--------
E
-
C
------
R
I
M
S
S
A
K
R
P
L
W
-
L
N
W
---
E
NPDIMSELLF
Q
N
N
E
------
I
-------
I
-------
F
K
N
G
-----
D
DL
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
GLDLRMLP
Y
G
C
L
S
-
I
----
G
D
C
-----
V
G
L
I
E
V
V
R
N
---
S
H
T
I
M
Q
I
Q
C
K
GFNS
H
T
L
H
Q
W
L
K
D
K
N
K
G
E
----------
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
-
G
I
G
DRHNSN
I
M
V
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
R
V
P
F
V
L
T
Q
---------
D
F
L
I
V
I
S
T
K
T
R
--
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
---
L
F
I
N
L
-----
F
S
M
M
L
G-
S
G
M
P
E
L
Q
S
F
D
D
I
A
------
Y
I
R
K
T
L
A
LDKT
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
DA----------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
52.40
17%
-2
- C9 -
-
5UBP
-
?
A:
[11-479]
------------------------------------------------------
P
D
K
--------
K
K
K
Y
M
I
N
D
A
K
---
T
I
Q
L
V
G
----
P
L
I
S
--------
S
-----
P
D
N
L
G
F
Q
----
K
R
S
H
-
K
A
R
E
L
P
R
F
L
I
N
Q
-----
E
P
Q
--------------------------------------------------------------
L
-----
E
K
-------
R
A
----
F
--
V
Q
D
P
W
D
-
K
A
-
N
Q
E
K
M
I
S
----
L
E
E
S
-----
I
-
D
------
D
-----
L
N
E
--------------
L
-----
Y
E
T
L
K
K
--
M
R
N
T
----------
E
--
R
S
I
---------
M
E
E
K
G
--
L
V
D
K
A
D
S
A
K
D
L
Y
D
A
I
-
V
-
F
Q
G
---------
T
-------------------------------------------------------------------
C
----
L
D
M
C
P
T
--
F
E
R
-
S
R
R
N
------
V
E
----
Y
T
-----------
V
-------
Y
S
Y
E
K
--------
N
Q
P
----------
N
D
K
K
--------------
A
S
R
T
K
----------------------
A
L
K
-------
V
F
A
R
P
A
A
--------------------------
A
A
A
P
P
----------
L
P
S
D
V
R
---------------------------
P
P
H
I
L
V
K
--
T
L
------
D
Y
----
I
V
D
N
L
--------------------
L
T
T
L
-------------------------------------------------------------------------------------------------------
P
E
S
E
G
F
L
W
D
R
M
R
S
I
R
Q
D
F
T
Y
-
Q
N
--
Y
SG
P
E
A
----------
V
D
-
C
N
E
R
I
-----------
V
R
-----------
I
-------------
H
L
--
L
I
L
H
I
M
V
K
S
N
----------
V
E
F
------------
S
L
Q
Q
E
L
E
Q
---
L
H
K
S
L
I
T
L
----
S
E
I
Y
---
D
D
V
R
S
S
---------
G
---
G
--
T
C
P
--
N
E
A
E
F
----
R
A
Y
--------
A
L
L
S
K
I
R
-
D
P
Q
-
Y
--------
D
E
---------
N
I
--------
Q
---------
R
L
P
K
H
I
F
Q
---------------------
D
K
L
V
Q
M
A
L
C
F
R
R
-
V
I
S
N
S
A
Y
------
T
E
R
G
F
V
K
--------
T
------------
E
N
-
C
L
-
N
F
Y
A
R
F
----
F
Q
--------
L
-
M
------
Q
-
S
P
S
L
P
L
L
M
G
-
F
F
L
---
Q
M
H
L
-------
T
D
I
R
------
F
-------
Y
-------
A
L
R
A
-----
L
--------
S
H
T
L
N
--------------------------------------------
K
---
K
H
K
P
I
P
F
I
Y
L
----
E
N
M
L
L
F
N
---------------------------
N
R
Q
E
I
I
E
F
C
N
Y
----
Y
S
-------
I
E
I
I
N
G
------
D
---------
A
A
D
L
---------
K
T
L
Q
H
Y
S
H
K
L
S
--
E
T
-------
Q
P
L
K
K
T
Y
L
T
C
L
E
---
R
R
L
Q
K
-----
T
------------------
T
------
Y
K
G
L
I
N
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
47.99
18%
-107
- C9 -
-
4GKI
1
?
C:
[65-255]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
T
---
D
E
M
V
R
L
N
W
----
L
T
A
-----
F
M
P
L
P
T
-
I
----
K
H
F
---
I
--
R
T
---
P
D
D
A
W
----
L
L
T
--------
T
A
I
P
G
K
T
-
A
F
Q
-
V
--------
L
E
---------
E
Y
--------
P
----------
D
S
G
E
N
I
V
---------------------
D
A
L
A
V
F
L
R
R
L
H
S
-
I
P
V
C
N
C
P
-
F
-
N
-
S
D
R
V
F
R
L
A
--------
Q
A
-
Q
S
--
R
M
N
N
G
L
V
D
-
A
S
-
D
F
D
D
E
R
----
N
G
--------
W
-
P
--------
V
E
Q
V
W
K
E
M
H
-
K
L
L
---
P
----------
F
S
P
D
------
S
-------
V
-------
V
T
H
G
-----
D
--------
F
S
L
D
N
L
I
------------------
F
D
-
E
----
G
K
L
-----
I
G
C
I
D
V
G
R
V
---
G
I
A
D
R
Y
Q
D
L
A
----
I
L
W
N
C
L
G
E
---
F
S
P
----------
S
L
Q
K
R
L
F
Q
K
Y
G
I
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
SP3
47.87
9%
23
* C7 *
-
1G5A
2
AMYS_NEIPO
A:
[1-628]
-----------------------------------SPN
S
Q
Y
L
K
T
R
I
L
DIY
T
P
E
Q
R
A
G
--------
I
E
K
-
S
E
D
W
R
Q
---
F
S
R
R
M
D
T
H
-
F
P
K
L
M
--------
N
-----
E
L
D
S
V
Y
G
----
N
N
E
A
-
L
-
L
P
M
L
E
M
L
L
A
Q
-----
A
W
Q
-
S
Y
S
---
Q
--
R
------------------------
N
----
S
---
S
L
----------
K
----
D
I
-----
D
I
-------
A
R
----
E
--
N
N
P
D
W
I
-
L
S
-
N
K
--
Q
V
G
----
G
V
C
Y
VDLFA
G
-
D
------
L
K
G
---
L
K
D
--------------
K
I
P
Y
F
Q
E
L
G
L
T
Y
--
L
H
L
M
----------
P
L
F
K
C
P
---------
E
G
K
S
D
GG
Y
A
V
S
S
Y
R
D
V
--
N
P
A
L
G
T
-
I
G
D
---------
L
R
------------
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V
I
A
A
-----------
L
H
E
--
A
G
----
I
------------------------
S
------
A
V
V
D
F
I
--
F
N
H
T
S
N
E
H
------
E
W
----
A
Q
-----------
R
C
A
A
G
D
P
L
F
D
N
F
Y
--------
Y
I
F
----------
P
D
R
R
M
P
D
Q
Y
D
R
--
T
L
R
E
I
F
P
D
Q
H
----------------------
P
G
G
-------
F
S
Q
L
E
D
G
--------------------------
R
W
V
W
T
T
FNSF
Q
W
D
L
N
-
Y
S
N
P
W
---------------------------
V
F
R
A
M
A
G
--
E
M
L
F
L
A
N
L
G
V
DILR
M
D
A
V
A
--------------------
F
I
W
K
-------------------------
Q
M
----
G
------
T
S
C
---------------------------------------------------------
E
----
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
V
--
F
---
F
K
----------
S
E
-
A
I
V
H
P
-----------
D
Q
-----------
V
-------------
V
Q
--
Y
I
G
Q
--
D
E
C
Q
----------
I
G
Y
N
P
L
-----
Q
M
A
L
L
W
N
T
L
A
T
R
---
E
V
N
L
L
H
Q
A
----
L
T
Y
R
---
H
N
L
P
E
H
T
-
A
----
W
V
N
---
Y
--
V
R
S
--
H
D
D
--------------------
I
G
W
T
-
F
A
D
-
E
--------
D
A
---------
A
Y
--------
L
---------
G
I
S
G
Y
D
H
R
---------------------
Q
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
-
Y
-
N
P
S
T
G
D
C
R
--------
V
S
G
T
A
-
A
A
L
V
G
L
A
Q
D
-
D
P
-
H
A
V
D
R
I
----
K
L
--------
L
-----------------
Y
S
-
I
A
L
---
S
----------
T
G
G
L
------
P
-------
L
-------
I
Y
L
G
-----
D
-------------------------------------------------------
E
V
G
---
T
L
N
D
D
----------
D
W
S
Q
D
S
N
K
S
D
D
S
R
----------
W
A
H
R
P
R
Y
N
E
A
L
Y
A
Q
R
N
D
P
S
----------------
T
A
A
G
Q
------
I
-
Y
Q
D
L
R
H
M
I
A
V
R
Q
---------
S
N
P
R
F
D
G
G
R
L
V
T
F
N
T
N
N
K
H
I
I
G
Y
I
R
N
N
A
L
L
A
F
G
N
---
F
S
E
Y
P
-----
Q
T
-----
V
T
A
H
T
-
L
Q
A
M
P
F
K
------
A
H
D
L
I
G
G
K
T
V
S
LN
Q
D
L
T
L
Q
PY
Q
V
M
W
L
EIA-------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
47.43
18%
-108
- C9 -
-
4GKH
2
?
A:
[65-255]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
T
---
D
E
M
V
R
L
N
W
----
L
T
A
-----
F
M
P
L
P
T
-
I
----
K
H
F
---
I
--
R
T
---
P
D
D
A
W
----
L
L
T
--------
T
A
I
P
G
K
T
-
A
F
Q
-
V
--------
L
E
---------
E
Y
--------
P
----------
D
S
G
E
N
I
V
---------------------
D
A
L
A
V
F
L
R
R
L
H
S
-
I
P
V
C
N
C
P
-
F
-
N
-
S
D
R
V
F
R
L
A
--------
Q
A
-
Q
S
--
R
M
N
N
G
L
V
D
-
A
S
-
D
F
D
D
E
R
----
N
G
--------
W
-
P
--------
V
E
Q
V
W
K
E
M
H
-
K
L
L
---
P
----------
F
S
P
D
------
S
-------
V
-------
V
T
H
G
-----
D
--------
F
S
L
D
N
L
I
------------------
F
D
-
E
----
G
K
L
-----
I
G
C
I
D
V
G
R
V
---
G
I
A
D
R
Y
Q
D
L
A
----
I
L
W
N
C
L
G
E
---
F
S
P
----------
S
L
Q
K
R
L
F
Q
K
Y
G
I
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
SP3
45.72
11%
14
- C7 -
-
1IWG
-
ACRB_ECOLI
A:
[7-1036]
DRP
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
LPVAQYPTIA
P
P
A
V
T
I
S
A
S
Y
P
GAD
A
K
T
V
Q
D
T
V
T
Q
-----------------
V
---
I
E
Q
N
M
N
--
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
-----
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
---
A
D
I
A
Q
V
Q
V
Q
N
K
-----
L
Q
L
-
A
M
P
---
L
LP
Q
E
V
Q
Q
Q
G
V
---------------
S
V
E
K
S
SS
S
---
F
L
----------
M
----
V
V
G
V
I
N
T
D
G
-------
T
M
----
T
--
Q
E
D
I
S
D
Y
V
A
-
A
N
M
K
D
A
I
----
S
R
T
S
-----
G
V
G
------
D
V
Q
---
L
F
G
SQYAM
R
I
W
M
N
P
N
E
L
N
-----
K
F
Q
L
T
P
--
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
--
A
G
Q
---------
L
G
G
T
P
--
P
V
K
G
Q
Q
L
N
A
S
I
I
A
Q
T
-
R
-
L
T
S
---------
T
E
------------
E
F
G
K
I
LLK--------
V
N
Q
--
D
G
S
R
V
L
L
------------------------
R
D
V
A
K
I
E
L
G
G
E
N
Y
--
D
I
I
-
A
E
F
N
------
G
Q
P
A
S
G
L
G
-----------
I
K
---
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
-----------
K
M
E
P
F
F
P
S
G
L
--
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
-------
L
F
L
Q
N
F
R
--------------------------
A
T
L
I
P
T
------
I
A
V
P
V
V
L
-
L
---------------------------
G
T
F
A
V
L
A
--
A
F
------
G
F
----
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
AEEGLPP----------
K
E
A
T
R
K
S
MG
Q
I
Q
------
G
A
L
V
G
I
A
M
V
L
S
A
V
F
VPMAFFGGSTGAI
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
MLKF
G
----
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
---
Y
L
----------
V
L
-
Y
L
I
I
V
-----------
V
G
-----------
M
-------------
A
Y
--
L
F
V
R
L
P
S
S
F
L
P
D
E
D
QG
V
F
M
T
M
V
Q
L
P
A
-----
G
A
---
T
Q
E
R
T
Q
K
---
V
L
N
E
V
T
H
Y
----
Y
L
T
K
---
E
K
N
N
V
E
S
-
V
----
F
A
V
---
N
GF
G
F
A
--
G
R
G
Q
N
----
T
G
I
--------
A
F
V
S
L
K
D
-
W
A
D
-
R
-------------------
P
G
--------
E
---------
E
N
K
V
E
A
I
T
---------------------
M
R
A
T
R
A
F
S
Q
I
K
D
-
A
M
V
F
A
F
N
L
P
-
A
-
I
V
E
L
G
T
A
T
--------
G
F
D
F
E
-
L
I
D
Q
A
G
-
L
G
-
H
E
-
K
L
T
Q
A
R
----
N
Q
--------
L
-
L
------
A
-
E
A
A
K
H
P
M
L
T
-
S
V
R
---
P
----------
N
G
L
E
------
D
-------
T
-------
P
Q
-------------------
F
K
I
D
------------------
I
D
-
Q
----
E
K
A
-----------
Q
A
L
---
G
V
--
S
I
N
D
I
N
----
T
T
L
G
A
A
W
------------------------------
G
G
S
Y
V
N
D
F
I
D
R
G
R
V
-------
K
K
V
Y
V
M
------
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
---------
W
Y
V
R
A
A
D
G
Q
M
V
--
P
------
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
-----
P
S
M
E
I
L
G
Q
A
A
P
G
-
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
L
P
T
G
V
G
Y
D
WSGNQ
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
ALYESWSIPFSV
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
GLTND
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
D
L
M
DKEGKGL
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
ISTGAGSG
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
T
A
TVLAIFFVPV
F
F
V
V
V
RRRFSRK
66
SP3
44.24
11%
10
- C5 -
-
1JRO
1
?
B:
[2-777]
SVGKPLPHDS
A
R
A
H
V
T
GQARYLDDLPCPAN
T
L
H
L
A
F
G
L
S
TEASAAITGLD
L
E
P
V
R
E
S
PGVI
A
V
F
T
A
A
D
L
P
H
D
-
N
D
---
A
S
P
A
P
S
P
E
P
V
L
A
T
G
--------
E
VHFVG
Q
P
I
F
L
V
A
----
A
T
S
H
R
A
A
R
I
A
A
R
K
A
R
I
T
-----
Y
A
P
-
R
P
A
---
I
--
L
T
L
D
Q
A
L
A
A
DSRFEG
G
P
V
I
W
A
R
G
D
V
E
----
T
---
A
L
----------
A
G
AA
H
L
A
-----
E
G
-------
C
F
----
E
I
G
G
Q
E
H
F
Y
-
L
E
-
G
Q
--
A
A
L
----
A
L
P
A
-----
E
-
G
------
G
V
V
---
I
H
C
SSQH
P
S
E
I
Q
H
K
V
A
-
H
-----
A
L
G
L
A
F
HD
V
R
V
E
----------
M
--
R
R
M
GGG------
F
G
G
K
E
--
S
Q
G
N
H
L
A
I
A
C
A
V
A
A
R
---
A
T
G
R
P
C
K
M
R
Y
D
R
D
D
------------
D
M
V
I
T
GKR
H
D
F
R
I
R
Y
R
I
G
A
D
A
S
G
K
L
L
G
A
------------------------
D
F
V
----
H
L
A
R
C
G
--
W
S
A
-
D
L
S
L
------
P
V
----
C
D
-----------
R
A
---
M
L
H
A
D
G
S
Y
--------
F
V
P
A
L
R
I
E
S
H
RLR
T
N
T
Q
S
N
---
T
A
--
F
R
G
F
G
G
P
Q
G
------------------------------------------------------------------
A
L
G
M
E
R
------
A
I
E
H
L
A
R
G
M
GRD------------------------
P
A
E
L
R
A
L
N
F
Y
D
------
P
P
----
E
K
K
T
Q
--------------------
T
T
H
Y
-------------------------------
G
------
Q
E
V
---------------------------------------------------------
A
----
D
C
V
-----
L
G
E
L
V
T
R
L
Q
K
S
A
N
F
T
--
T
---
R
R
----------
A
E
-
I
A
A
W
N
-----------
S
T
N
RT
L
A
R
G
I
A
L
S
P
-------------
V
K
--
F
G
I
S
F
T
L
T
H
L
N
Q
A
G
A
L
----
V
Q
I
Y
T
D
-----
G
S
V
A
L
N
H
G
G
T
E
M
GQG
L
H
A
K
M
V
Q
V
----
A
A
A
V
---
L
G
I
D
P
V
Q
-
V
----
R
I
T
---
A
--
T
D
T
--
S
K
V
P
N
----
T
S
A
--------
T
A
--
A
S
S
-
G
A
D
-
M
--------
N
G
---------
M
A
--------
V
---------
K
D
A
C
E
T
L
R
---------------------
G
R
L
A
G
F
V
A
A
R
E
G
-
C
A
A
R
D
V
I
F
D
----------
A
--------
G
Q
V
Q
A
-
S
G
K
S
W
R
F
A
E
-
I
V
-
A
A
A
Y
M
A
----
R
I
SL
S
A
T
G
F
Y
A
-
T
------
P
-
K
L
S
W
D
R
L
R
G
-
Q
G
R
---
P
----------
F
L
Y
F
------
A
-------
Y
-------
G
A
A
I
T
E
V
V
I
D
--------
R
L
T
G
E
N
R
------------------
I
L
-------
R
T
-----
D
I
L
H
D
A
G
A
S
-------
L
N
P
A
L
D
----
I
G
Q
I
E
G
A
Y
V
Q
G
A
G
W
----------
L
T
T
E
E
L
V
--
W
D
H
C
G
R
L
M
T
-----------------
H
A
P
S
T
------
Y
K
I
P
A
F
S
D
R
P
R
I
F
N
V
--------
A
L
W
D
Q
P
----
N
--
R
E
E
T
I
F
R
S
K
A
V
G
E
P
P
F
L
L
G
I
S
---
A
F
L
A
L
H
D
A
C
A
A
C
-----
G
P
H
W
P
-
D
L
Q
A
P
A
T
P
E
A
V
L
A
A
V
R
R
A
E
G
RA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
43.48
21%
-26
- C9 -
-
4FEW
2
?
A:
[53-227]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
L
K
H
G
K
G
S
V
A
---
N
D
V
T
D
E
M
V
----
R
L
N
W
---
L
T
A
F
M
P
L
P
T
----
I
K
H
---
F
--
I
R
T
--
P
D
D
A
W
----
L
L
T
--------
T
A
I
P
G
K
T
-
A
F
Q
-
V
--------
L
E
---------
E
Y
--------
P
----------
D
S
G
E
N
I
V
---------------------
D
A
L
A
V
F
L
R
R
L
H
S
-
I
P
V
C
N
-----------
C
P
F
N
--------
S
D
R
V
F
-
R
L
A
Q
A
Q
S
R
M
-
N
N
-
G
L
V
D
------
A
S
--------
D
-
F
------
D
-
D
E
R
N
G
W
P
V
E
-
Q
V
W
---
K
----------
E
M
H
K
------
L
-------
L
P
F
S
P
D
S
V
V
T
H
G
-----
D
--------
F
S
L
D
N
L
I
------------------
F
D
-
E
----
G
K
L
-----
I
G
C
I
D
V
G
R
V
---
G
I
A
D
R
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
43.43
21%
-25
- C9 -
-
4FEU
2
?
A:
[53-227]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
L
K
H
G
K
G
S
V
A
---
N
D
V
T
D
E
M
V
----
R
L
N
W
---
L
T
A
F
M
P
L
P
T
----
I
K
H
---
F
--
I
R
T
--
P
D
D
A
W
----
L
L
T
--------
T
A
I
P
G
K
T
-
A
F
Q
-
V
--------
L
E
---------
E
Y
--------
P
----------
D
S
G
E
N
I
V
---------------------
D
A
L
A
V
F
L
R
R
L
H
S
-
I
P
V
C
N
-----------
C
P
F
N
--------
S
D
R
V
F
-
R
L
A
Q
A
Q
S
R
M
-
N
N
-
G
L
V
D
------
A
S
--------
D
-
F
------
D
-
D
E
R
N
G
W
P
V
E
-
Q
V
W
---
K
----------
E
M
H
K
------
L
-------
L
P
F
S
P
D
S
V
V
T
H
G
-----
D
--------
F
S
L
D
N
L
I
------------------
F
D
-
E
----
G
K
L
-----
I
G
C
I
D
V
G
R
V
---
G
I
A
D
R
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
43.17
21%
-22
- C9 -
-
4EJ7
2
?
A:
[73-247]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
L
K
H
G
K
G
S
V
A
---
N
D
V
T
D
E
M
V
----
R
L
N
W
---
L
T
A
F
M
P
L
P
T
----
I
K
H
---
F
--
I
R
T
--
P
D
D
A
W
----
L
L
T
--------
T
A
I
P
G
K
T
-
A
F
Q
-
V
--------
L
E
---------
E
Y
--------
P
----------
D
S
G
E
N
I
V
---------------------
D
A
L
A
V
F
L
R
R
L
H
S
-
I
P
V
C
N
-----------
C
P
F
N
--------
S
D
R
V
F
-
R
L
A
Q
A
Q
S
R
M
-
N
N
-
G
L
V
D
------
A
S
--------
D
-
F
------
D
-
D
E
R
N
G
W
P
V
E
-
Q
V
W
---
K
----------
E
M
H
K
------
L
LPFSPDS
V
-------
V
T
H
G
-----
D
--------
F
S
L
D
N
L
I
------------------
F
D
-
E
----
G
K
L
-----
I
G
C
I
D
V
G
R
V
---
G
I
A
D
R
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
42.89
21%
-19
- C9 -
-
4GKI
3
?
A:
[53-227]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
L
K
H
G
K
G
S
V
A
---
N
D
V
T
D
E
M
V
----
R
L
N
W
---
L
T
A
F
M
P
L
P
T
----
I
K
H
---
F
--
I
R
T
--
P
D
D
A
W
----
L
L
T
--------
T
A
I
P
G
K
T
-
A
F
Q
-
V
--------
L
E
---------
E
Y
--------
P
----------
D
S
G
E
N
I
V
---------------------
D
A
L
A
V
F
L
R
R
L
H
S
-
I
P
V
C
N
-----------
C
P
F
N
--------
S
D
R
V
F
-
R
L
A
Q
A
Q
S
R
M
-
N
N
-
G
L
V
D
------
A
S
--------
D
-
F
------
D
-
D
E
R
N
G
W
P
V
E
-
Q
V
W
---
K
----------
E
M
H
K
------
L
-------
L
PFSPDSV
V
T
H
G
-----
D
--------
F
S
L
D
N
L
I
------------------
F
D
-
E
----
G
K
L
-----
I
G
C
I
D
V
G
R
V
---
G
I
A
D
R
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
42.78
21%
-23
- C9 -
-
4FEV
2
?
A:
[53-227]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
L
K
H
G
K
G
S
V
A
---
N
D
V
T
D
E
M
V
----
R
L
N
W
---
L
T
A
F
M
P
L
P
T
----
I
K
H
---
F
--
I
R
T
--
P
D
D
A
W
----
L
L
T
--------
T
A
I
P
G
K
T
-
A
F
Q
-
V
--------
L
E
---------
E
Y
--------
P
----------
D
S
G
E
N
I
V
---------------------
D
A
L
A
V
F
L
R
R
L
H
S
-
I
P
V
C
N
-----------
C
P
F
N
--------
S
D
R
V
F
-
R
L
A
Q
A
Q
S
R
M
-
N
N
-
G
L
V
D
A
------
S
--------
D
-
F
------
D
-
D
E
R
N
G
W
P
V
E
-
Q
V
W
---
K
----------
E
M
H
K
------
L
-------
L
P
F
S
P
D
S
V
V
T
H
G
-----
D
--------
F
S
L
D
N
L
I
------------------
F
D
-
E
----
G
K
L
-----
I
G
C
I
D
V
G
R
V
---
G
I
A
D
R
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
42.56
21%
-25
- C9 -
-
4GKH
2
?
A:
[53-227]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
L
K
H
G
K
G
S
V
A
---
N
D
V
T
D
E
M
V
----
R
L
N
W
---
L
T
A
F
M
P
L
P
T
----
I
K
H
---
F
--
I
R
T
--
P
D
D
A
W
----
L
L
T
--------
T
A
I
P
G
K
T
-
A
F
Q
-
V
--------
L
E
---------
E
Y
--------
P
----------
D
S
G
E
N
I
V
---------------------
D
A
L
A
V
F
L
R
R
L
H
S
-
I
P
V
C
N
-----------
C
P
F
N
--------
S
D
R
V
F
-
R
L
A
Q
A
Q
S
R
M
-
N
N
-
G
L
V
D
------
A
S
--------
D
-
F
------
D
-
D
E
R
N
G
W
P
V
E
-
Q
V
W
---
K
----------
E
M
H
K
------
L
-------
L
P
F
S
P
DSV
V
T
H
G
-----
D
--------
F
S
L
D
N
L
I
------------------
F
D
-
E
----
G
K
L
-----
I
G
C
I
D
V
G
R
V
---
G
I
A
D
R
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
42.21
21%
-23
- C9 -
-
4FEX
2
?
A:
[53-227]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
L
K
H
G
K
G
S
V
A
---
N
D
V
T
D
E
M
V
----
R
L
N
W
---
L
T
A
F
M
P
L
P
T
----
I
K
H
---
F
--
I
R
T
--
P
D
D
A
W
----
L
L
T
--------
T
A
I
P
G
K
T
-
A
F
Q
-
V
--------
L
E
---------
E
Y
--------
P
----------
D
S
G
E
N
I
V
---------------------
D
A
L
A
V
F
L
R
R
L
H
S
-
I
P
V
C
N
-----------
C
P
F
N
--------
S
D
R
V
F
-
R
L
A
Q
A
Q
S
R
M
-
N
N
-
G
L
V
D
A
------
S
--------
D
-
F
------
D
-
D
E
R
N
G
W
P
V
E
-
Q
V
W
---
K
----------
E
M
H
K
------
L
-------
L
P
F
S
P
D
S
V
V
T
H
G
-----
D
--------
F
S
L
D
N
L
I
------------------
F
D
-
E
----
G
K
L
-----
I
G
C
I
D
V
G
R
V
---
G
I
A
D
R
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
SP3
40.60
9%
30
- C7 -
-
1G5A
2
AMYS_NEIPO
A:
[1-554]
-----------------------------------SPN
S
Q
Y
L
K
T
R
I
L
DIY
T
P
E
Q
R
A
G
--------
I
E
K
-
S
E
D
W
R
Q
---
F
S
R
R
M
D
T
H
-
F
P
K
L
M
--------
N
-----
E
L
D
S
V
Y
G
----
N
N
E
A
-
L
-
L
P
M
L
E
M
L
L
A
Q
-----
A
W
Q
-
S
Y
S
Q
RN
S
--
S
L
K
D
I
D
I
A
---------------
R
E
N
----
N
---
P
D
----------
W
----
I
L
-----
S
N
-------
K
Q
V
G
G
V
C
--
Y
V
D
L
F
A
-
G
D
L
K
G
L
K
D
K
I
P
---
Y
F
Q
E
--------------------------------------------
L
G
L
T
Y
--
L
H
L
M
----------
P
L
F
K
C
P
---------
E
G
K
S
D
GG
Y
A
V
S
S
Y
R
D
V
--
N
P
A
L
G
T
-
I
G
D
---------
L
R
------------
E
V
I
A
A
-----------
L
H
E
--
A
G
----
I
------------------------
S
------
A
V
V
D
F
I
--
F
N
H
T
S
N
E
H
------
E
W
----
A
Q
-----------
R
C
A
A
G
D
P
L
F
D
N
F
Y
--------
Y
I
F
----------
P
D
R
R
M
P
D
Q
Y
D
R
--
T
L
R
E
I
F
P
D
Q
H
----------------------
P
G
G
-------
F
S
Q
L
E
D
G
--------------------------
R
W
V
W
T
T
FNSF
Q
W
D
L
N
-
Y
S
N
P
W
---------------------------
V
F
R
A
M
A
G
--
E
M
L
-----
F
L
----
A
N
L
G
V
--------------------
D
I
L
R
--------------------
M
-
D
A
V
A
F
----
I
------
W
K
Q
---------------------------------------------------------
M
GTSC
E
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
--
V
---
F
F
----------
K
S
E
A
I
V
H
P
-----------
D
Q
-----------
V
-------------
V
Q
--
Y
I
G
Q
--
D
E
C
Q
----------
I
G
Y
N
P
L
-----
Q
M
A
L
L
W
N
T
L
A
T
R
---
E
V
N
L
L
H
Q
A
----
L
T
Y
R
---
H
N
L
P
E
H
T
-
A
----
W
V
N
---
Y
--
V
R
S
--
H
D
D
I
--------------------
G
W
T
-
F
A
D
-
E
--------
D
A
---------
A
Y
--------
L
---------
G
I
S
G
Y
D
H
R
---------------------
Q
F
L
N
R
F
F
V
N
R
F
D
-
G
S
F
A
R
G
V
P
F
-
Q
Y
N
P
S
T
G
D
C
R
--------
V
S
G
T
A
-
A
A
L
V
G
L
A
Q
D
-
D
P
-
H
A
V
D
R
I
----
K
L
--------
L
-----------------
Y
S
-
I
A
L
---
S
----------
T
G
G
L
------
P
-------
L
-------
I
Y
L
G
-----
D
E-------
V
G
T
L
N
------------------------------------------
D
D
D
---
W
S
Q
D
S
---------------
N
K
S
D
D
S
R
W
----------
A
H
R
P
R
Y
N
E
A
L
Y
A
Q
R
N
D
P
------------------
S
T
A
A
G
------
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
---------
S
N
P
R
F
D
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
40.35
16%
-50
- C9 -
-
3ATT
2
Y3168_MYCTU
A:
[73-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
D
---
H
Q
F
E
V
I
R
L
----
V
G
E
L
---
T
D
V
P
V
P
R
-
V
----
R
W
I
---
E
--
T
T
G
DV
L
G
T
P
F
----
F
L
M
--------
D
Y
V
E
G
V
V
-
P
P
D
-
V
--------
M
P
YTFGDNWFA
D
A
--------
P
---------
A
E
R
Q
R
Q
L
Q
---------------------
D
A
T
V
A
A
L
A
T
L
H
S
-
I
P
N
A
Q
N
T
-
F
-
S
-
F
L
T
-------------
D
T
T
-----
L
H
R
H
F
N
W
-
V
R
-
S
W
Y
D
F
A
----
V
E
--------
G
-
I
G
R
S
P
--
L
-
L
E
R
T
F
E
W
L
Q
-
S
H
W
P
D
D
A
----------
A
A
R
E
------
P
-------
V
-------
L
L
W
G
-----
D
--------
A
R
V
G
N
V
L
------------------
Y
R
-
D
----
F
Q
P
-----
V
A
V
L
D
W
E
M
V
---
A
L
G
P
R
E
L
D
V
A
----
W
M
I
F
A
H
R
V
F
Q
E
L
A
G
L
A
TLPGLPEV
M
R
E
D
D
V
R
A
T
Y
Q
A
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
39.86
15%
-34
- C9 -
-
5IGH
-
?
A:
[62-255]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
E
---
P
E
A
R
V
L
A
M
----
L
K
N
R
---
L
P
F
A
V
P
D
-
W
----
R
V
A
---
N
--
A
E
L
--
V
A
Y
P
M
LEDS
T
A
M
--------
V
I
Q
P
G
S
S
-
T
P
D
-
W
--------
V
--------------------
V
---------
P
Q
D
S
E
V
F
A
---------------------
E
S
F
A
T
A
L
A
A
L
H
A
-
V
P
I
S
A
A
V
D
A
-
G
-
M
L
I
R
T
P
T
---------
Q
--
A
R
-
Q
K
V
A
D
D
V
D
R
-
V
R
-
R
E
F
V
V
N
----
D
K
----------
R
--------
L
H
R
W
Q
R
W
L
D
-
D
D
S
---
S
----------
W
P
D
F
------
S
-------
V
-------
V
V
H
G
-----
D
--------
L
Y
V
G
H
V
L
------------------
I
D
-
N
T---
E
R
V
-----
S
G
M
I
D
W
S
E
A
---
R
V
D
D
P
A
I
D
M
A
----
A
H
L
M
V
F
G
------
E
----------
E
G
L
A
K
L
L
L
T
Y
E
A
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
39.81
15%
-2
- C9 -
-
5IQI
1
AACA_STAAU
C:
[62-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
A
---
K
E
K
A
I
Y
N
F
----
L
N
T
N
LE-
T
N
V
K
I
P
N
-
I
----
E
Y
S
---
Y
--
I
S
---
D
E
L
S
I
----
L
G
Y
--------
K
E
I
K
G
T
F
-
L
T
P
E
I
--------
Y
S
---------
T
M
--------
S
---------
E
E
E
Q
N
L
L
K
---------------------
R
D
I
A
S
F
L
R
Q
M
H
G
-
L
D
Y
T
D
I
S
E
C
-
T
----
I
D
N
K
Q
------------------
N
V
L
E
E
-
Y
I
-
L
L
R
E
T
I
----
Y
N
--------
D
-
L
T
D
I
E
K
D
Y
-
I
E
S
F
M
E
R
L
N
-
A
T
T
---
V
----------
F
E
G
K
------
K
-------
C
-------
L
C
H
N
-----
D
--------
F
S
C
N
H
L
L
------------------
L
D
-
G
N---
N
R
L
-----
T
G
I
I
D
F
G
D
S
---
G
I
I
D
E
Y
C
D
F
I
----
Y
L
L
E
D
S
E
E
E
--
I
G
T
----------
N
F
G
E
D
I
L
R
M
Y
G
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
36.10
23%
19
- C9 -
-
5IWU
2
?
A:
[59-255]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
K
---
V
E
K
Q
A
L
D
L
----
V
N
K
Y
A--
I
S
F
Q
A
P
N
-
W
----
I
I
Y
------------
T
E
E
L
----
I
A
Y
--------
K
K
L
D
G
V
P
-
A
G
T
-
I
--------
D
H
---------
N
I
GNYIWEID
I
---------
N
N
V
P
E
L
F
H
---------------------
K
S
L
G
R
V
L
A
E
L
H
S
-
I
P
S
N
K
A
A
A
L
-
D
-----
L
V
V
H
--------
T
P
E
-------
E
A
R
M
S
-
M
K
-
Q
R
M
D
A
V
----
R
A
--------
K
-
F
G
V
G
E
N
-
L
-
W
N
R
W
Q
A
W
L
N
-
D
D
D
---
M
----------
W
P
K
K
------
T
-------
G
-------
L
I
H
G
-----
D
--------
V
H
A
G
H
T
M
------------------
I
D
K
D
----
A
N
V
-----
T
G
L
I
D
W
T
E
A
---
K
V
T
D
V
S
H
D
F
I
----
F
N
Y
R
A
F
------
G
E
----------
E
G
L
E
A
L
I
L
A
Y
K
E
I
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
35.14
15%
17
- C9 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
--
M
---
R
I
----------
S
P
-
E
L
K
K
L
-----------
I
E
-----------
K
-------------
Y
R
--
C
V
K
D
T
E
G
M
S
P
----------
A
K
V
Y
K
L
V
G
EN
E
N
L
Y
L
K
M
T
D
S
R
Y
K
---
G
T
T
Y
D
V
E
R
----
E
K
D
M
---
M
L
W
L
E
G
K
-
L
PVPK
V
L
H
---
F
--
E
R
H
--
D
G
W
S
N
----
L
L
M
--------
S
E
A
D
G
V
L
-
C
S
E
-
E
--------
Y
E
---------
D
E
-------------------
Q
S
P
E
K
I
I
---------------------
E
L
Y
A
E
C
I
R
L
F
H
S
-
I
-----------
D
I
S
D
C
P
Y
T
--------
N
S
L
D
S
-
R
L
A
E
L
D
Y
L
L
-
N
N
-
D
L
A
D
V
D
----
C
E
--------
N
-
W
------
E
-
E
D
T
P
F
K
D
P
R
-
E
L
Y
---
D
----------
F
L
K
T
E
K
P
E
E
E
L
-------
V
-------
F
S
H
G
-----
D
--------
L
G
D
S
N
I
F
------------------
V
K
-
D
----
G
K
V
-----
S
G
F
I
D
L
G
R
S
---
G
R
A
D
K
W
Y
D
I
A
----
F
C
V
R
S
I
R
E
D
I
G
E
E
-----------
Q
Y
V
E
L
F
F
D
L
L
G
I
K
P
D
W
E
K
I
K
Y
Y
I
-
L
L
D
-------
E
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
33.57
15%
-27
- C9 -
-
3TDW
1
?
A:
[55-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
N
---
K
E
I
Q
L
L
P
L
----
L
V
G
C
---
V
K
V
N
I
P
Q
-
Y
----
V
Y
I
---
G
--
K
R
S
--
D
G
N
P
F
----
V
G
Y
--------
R
K
V
Q
G
Q
I
-
L
G
E
-
D
G
-------
M
A
---------
V
L
--------
P
---------
D
D
A
K
D
R
L
A
---------------------
L
Q
L
A
E
F
M
N
E
L
S
A
-
F
P
V
E
T
A
I
S
A
------
G
V
P
V
T
--------
N
L
K
N
K
I
L
L
L
S
E
A
V
E
D
Q
V
F
P
L
L
D
E
S
L
----
R
D
--------
Y
-
L
--------
T
L
R
F
Q
S
Y
M
T
-
H
P
V
---
Y
----------
T
R
Y
T
------
P
-------
R
-------
L
I
H
G
-----
D
--------
L
S
P
D
H
F
L
------------------
T
N
-
L
NSRQ
T
P
L
-----
T
G
I
I
D
F
G
D
A
---
A
I
S
D
P
D
Y
D
Y
V
----
Y
L
L
E
D
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
30.57
16%
20
- C9 -
-
4DCA
1
?
A:
[74-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
---
R
E
L
E
L
Y
R
F
----
L
E
N
C
K--
L
S
Y
Q
I
P
A
-
V
----
V
Y
Q
------------
S
D
R
F
----
N
I
M
--------
K
Y
I
K
G
E
R
-
I
T
Y
E
Q
--------
Y
H
---------
K
L
--------
S
---------
E
K
E
K
D
A
L
A
---------------------
Y
D
E
A
T
F
L
K
E
L
H
S
-
I
E
I
D
C
S
V
S
L
F
S
-
D
A
L
V
N
K
K
D
--------
K
F
L
Q
D
K
K
L
L
I
S
I
L
E
K
-
E
Q
-
L
L
T
D
E
M
----
L
E
--------
H
-
I
------
E
---
T
I
Y
E
N
I
L
S
N
A
V
---
L
----------
F
K
Y
T
------
P
-------
C
-------
L
V
H
N
-----
D
--------
F
S
A
N
N
M
I
------------------
F
R
-
N
----
N
R
L
-----
F
G
V
I
D
F
G
D
F
---
N
V
G
D
P
D
N
D
F
L
----
C
L
L
D
C
S
--
T
D
D
F
G
K
----------
E
F
G
R
K
V
L
K
Y
Y
Q
H
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
29.28
16%
-4
- C9 -
-
1L8T
2
KKA3_ENTFL
A:
[55-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
E
---
R
E
K
D
M
M
L
W
----
L
E
G
-----
K
L
P
V
P
K
-
V
----
L
H
F
---
E
--
R
H
---
D
G
W
S
N
----
L
L
M
--------
S
E
A
D
G
V
L
-
C
S
E
-
E
--------
Y
E
---------
D
-------------------
E
Q
S
P
E
K
I
I
---------------------
E
L
Y
A
E
C
I
R
L
F
H
S
-
I
D
I
S
D
C
P
Y
T
-
N
-
S
L
D
S
---
R
--------
L
A
E
L
D
-
Y
L
L
N
N
D
L
A
D
--
V
-
D
C
E
N
W
E
----
E
D
--------
T
P
F
K-----
D
-
P
R
E
L
Y
D
F
L
K
-
T
-
E
---
K
----------
P
E
E
E
------
L
-------
V
-------
F
S
H
G
-----
D
--------
L
G
D
S
N
I
F
------------------
V
K
-
D
----
G
K
V
-----
S
G
F
I
D
L
G
R
S
---
G
R
A
D
K
W
Y
D
I
A
----
F
C
V
R
S
I
R
E
D
I
-
G
E
E
----------
Q
Y
V
E
L
F
F
D
L
L
G
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
28.51
16%
-2
- C9 -
-
3TM0
2
KKA3_ENTFL
A:
[55-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
E
---
R
E
K
D
M
M
L
W
----
L
E
G
-----
K
L
P
V
P
K
-
V
----
L
H
F
---
E
--
R
H
---
D
G
W
S
N
----
L
L
M
--------
S
E
A
D
G
V
L
-
C
S
E
-
E
--------
Y
E
---------
D
-------------------
E
Q
S
P
E
K
I
I
---------------------
E
L
Y
A
E
C
I
R
L
F
H
S
-
I
D
I
S
D
C
P
Y
T
-
N
-
S
L
D
S
---
R
--------
L
A
E
L
D
-
Y
L
L
N
N
D
L
A
D
--
V
-
D
C
E
N
W
E
----
E
D
--------
T
P
F
K-----
D
-
P
R
E
L
Y
D
F
L
K
-
T
-
E
---
K
----------
P
E
E
E
------
L
-------
V
-------
F
S
H
G
-----
D
--------
L
G
D
S
N
I
F
------------------
V
K
-
D
----
G
K
V
-----
S
G
F
I
D
L
G
R
S
---
G
R
A
D
K
W
Y
D
I
A
----
F
C
V
R
S
I
R
E
D
I
-
G
E
E
----------
Q
Y
V
E
L
F
F
D
L
L
G
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------