@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : D4L2V5_9FIRM: (2019-01-27 )
MNKQTLSYDEETRGKTVINHMGGVFLYNRPEQILEQYELEVKSISRGRDSYQCDTEQGPKILREYRGSKERAGFLADMLDHLSGQGRTVETVMRTKEGEPFSVNEEETKYILYQAFPGAECDTKNRADMLSAVRELALLHQSAQNYEGSVPEFLKSGQNNLLLLYEKRNRELNKVRNYIRAKKKKNDFEMMFAVWYPEYVKKAQETTDILKDLGIQEQLIGFCHGDYNQHNVIFSREGIAVVHFENFLYQESVGDLANFIRKMMEKNNWNAGLGMDLIRGYDRVRKLSPEELKYLYVYLAYPEKFWKIANRYYNSHKAWLSGRNIEKLEKVVAQEDAREQFLQMLFHFTV
Atome Classification :
(20 SA)
---------------...--.--.....10------........20........---30........----40.-...---...-----.-----.--50.----...-.---..-.---------60...----.--..----.----.----70---.-.......80...-..------.-.-.90.--.......100...----.-...110-----.........120--.--------.--.---.---....130.-......140.--....----..------150..---....--.160..--.....170-......------..180......----.190.....---..--200.......----------210.---.------..------....---220.......230..-..----.---.-.-240...-....250....-------...260-------------..-.--------------.----------------.----------.--.-.270.....---...280..--..------....290..-------.------...-------------.300.......---310.......320-.-----........330......---.340.......350------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------MNK--Q--TLSYDEE------TR
G
K
T
V
I
N
HMG
G
V
F
L
YN
R
---
P
E
Q
I
L
E
Q
Y
E
L
----
E
-
V
-
K
S
I---SRG-----R-----D--SYQ----CDT-E---Q
G
-
P
---------
K
I
L
R
E
----Y--RG----
S
----
K
----
E
R
---
A
-
G
F
L
A
D
M
L
D
HLSG-QG------
R
-
T
-
V
E
T
V
--
M
RTKEGEPFSVNE----E-E
T
K
Y
-------
I
L
Y
QAFPGAEC---D--------T--K---
N
---
R
A
D
M
L
S
A
V
-
R
E
L
A
L
L
H
Q
S
A
--QNYE----G
S
------
V
P
E
F
L
---
K
SGQ--N
N
L
L
L
L
--
Y
E
K
RN
R
E
--
L
N
K
V
R
N
------
Y
I
R
A
KKKKND
F
----
E
M
M
F
A
VW
Y
P
---
E
Y
--
V
K
K
A
Q
E
T
T
D
I
----------
L
-
K
D---L------G
I
------
Q
E
Q
L
---
I
G
F
CHGDYNQH
N
V
I
F
-SR----E---
G
-
I
-
A
V
V
H
F
E
-
N
F
L
Y
Q
E
S
V
G
D
L
-------
A
N
F
I
R
--------------
K
M
-
M
--------------E----------------K----------N--N-WN-AGL
G
M
D
---
L
I
R
G
Y
-
D
R
--
V
R------KL
S
P
E
E
L
K
Y
-------
L
------
Y
V
Y
-------------LAY
P
E
K
F
W
K
I
A
---
N
R
Y
Y
N
S
H
K
A
W
L---S-----GR
N
I
E
K
L
E
K
V
V
A
Q
E
D
A
R
---
E
Q
F
L
Q
M
L
F
H
FTV--------------------
22
HHSearch
78.82
18%
10
- C5 -
-
4PDY
1
?
A:
[23-346]
-----------------------------------------------------
I
---
P
Q
A
V
V
S
K
Y
D
L
----
A
-
I
-
Q
Q
R
---
H
A
D
-----------
G
--
N
I
E
----
V
W
T
D
S
---
K
G
R
R
---------
Y
A
A
K
R
----
S
--
S
I
----
A
----
P
----
A
H
---
C
-
R
I
M
V
Q
C
L
R
H
A
Q
E
-
Q
G
------
F
T
K
-
F
A
R
F
--
V
T
T
S
S
N
A
P
-
Y
V
R
H
----
G
-
D
F
T
Y
-------
Y
V
T
E
W
V
S
G
Q
P
A
---
N
--------
F
--
G
---
L
---
P
E
H
V
A
Q
T
A
-
Y
T
L
A
Q
F
H
E
A
T
--
R
S
F
R
----
T
D
------
W
K
------------
D
D
V
F
G
L
--
F
Q
A
R
W
R
D
--
L
R
Q
M
W
L
------
G
A
D
R
K
R
E
K
D
A
F
----
D
Q
L
L
L
S
M
R
D
---
E
L
--
H
R
D
A
A
E
S
L
A
L
----------
F
-
E
D
---
R
------
D
V
I
A
Y
L
E
A
E
R
S
S
---
G
G
W
C
H
L
D
V
I
P
S
N
C
L
Y
-
T
P
Q---
H
---
Q
-
V
-
V
L
I
D
F
E
-
L
A
R
P
A
P
R
A
L
D
M
-------
A
H
L
L
R
--------------
R
S
-
L
--------------
E
----------------
R
----------
G
--
N
-
W
D
-
G
H
L
A
Y
A
---
C
F
L
H
F
-
D
A
--
V
R
------
N
I
P
K
S
E
Y
R
A
-------
V
------
E
A
I
-------------
L
R
F
P
Y
L
P
W
R
I
A
---
H
A
R
Y
H
F
---
A
A
---
D
-----
P
S
Q
L
D
A
L
Q
Q
Y
A
V
Q
A
E
K
R
---
Q
A
F
L
A
S
L
R
Q
Q
V
---------------------
23
HHSearch
73.64
17%
24
- C5 -
-
2Q83
5
COTI_BACSU
A:
[22-345]
-----------------------------------------------------
L
---
A
E
N
V
L
Q
G
W
D
V
----
Q
-
A
-
E
K
I
---
D
V
I
-----
Q
A----
L
--
V
W
K
----
V
H
T
-
D
---
S
G
-
A
---------
V
C
L
K
R
----
I
--
H
R
----
P
----
E
----
K
K
---
A
-
L
F
S
I
F
A
Q
D
Y
L
A
K
-
K
G
------
M
-
N
-
V
P
G
I
--
L
P
N
K
K
G
S
L
-
Y
S
K
H
----
G
-
S
F
L
F
-------
V
V
Y
D
W
I
E
G
R
P
F
---
E
--------
L
--
T
---
V
---
K
Q
D
L
E
F
I
M
-
K
G
L
A
D
F
H
T
A
S
--
V
G
Y
Q
----
P
P
------
N
G
V
P
I
---
F
T
K
L
--
G
R
W
P
N
H
--
Y
T
K
R
C
K
Q
--
M
E
T
W
K
L
------
M
A
E
A
-
E
K
E
D
P
F
----
S
Q
L
Y
L
Q
E
I
D
---
G
F
--
I
E
D
G
L
R
I
K
D
R
----------
L
-
L
Q
---
S
T
Y
V
P
W
T
E
Q
------
L
K
K
S
---
P
N
L
C
H
Q
D
Y
G
T
G
N
T
L
L
-
G
E
N---
E
---
Q
-
I
-
W
V
I
D
L
D
-
T
V
S
F
D
L
P
I
R
D
L
-------
R
K
M
I
I
--------------
P
L
-
L
--------------
D
----------------
T
----------
T
G-
V
-
W
D
-
D
E
T
F
N
V
---
M
L
N
A
Y
-
E
S
--
R
A
------
P
L
T
E
E
Q
K
Q
V
-------
M
------
F
I
D
-------------
M
L
F
P
Y
E
L
Y
D
V
I
---
R
E
K
Y
V
R
K
S
A
L
P
---
K
---------
E
E
L
E
S
A
F
E
Y
E
R
I
K
---
A
N
A
L
R
Q
L
-------------------------
1
PsiBlast_PDB
67.97
19%
-15
- C5 -
-
2Q83
4
COTI_BACSU
A:
[49-317]
---------------------------------------------------------------------------------------------------
W
K
----
V
H
T
-
D
---
S
G
-
A
---------
V
C
L
K
R
----
I
--
H
R
----
P
----
E
----
K
K
---
A
-
L
F
S
I
F
A
Q
D
Y
L
A
K
-
K
G
------
M
-
N
-
V
P
G
I
--
L
P
N
K
K
G
S
L
Y
S
-
K
H
----
G
-
S
F
L
F
-------
V
V
Y
D
W
I
E
G
R
P
F
---
E
--------
L
--
T
---
V
---
K
Q
D
L
E
F
I
M
-
K
G
L
A
D
F
H
T
A
S
--
V
G
Y
Q
P
P
--
N
G
------
V
P
I
F
T
---
K
L
G
R
W
P
N
H
------
Y
T
K
R
C
K
Q
--
M
E
T
W
K
L
------
M
A
E
A
-
E
K
E
D
P
F
----
S
Q
L
Y
L
Q
E
I
D
---
G
F
--
I
E
D
G
L
R
I
K
D
R
----------
L
-
L
Q
ST
Y
V
------
P
W
------
T
E
Q
L
K
K
S
P
N
L
C
H
Q
D
Y
G
T
G
N
T
L
L
-
G
E
N---
E
---
Q
-
I
-
W
V
I
D
L
D
-
T
V
S
F
D
L
P
I
R
D
L
-------
R
K
M
I
I
--------------
P
L
-
L
--------------
D
----------------
T
----------
T
--
G
V
W
D
-
D
E
T
F
N
V
---
M
L
N
A
Y
-
E
S
--
R
A
------
P
L
T
E
E
Q
K
Q
V
-------
M
------
F
I
D
-------------
M
L
F
P
Y
E
L
Y
D
V
I
---
R
E
K
Y
--------------------------------------------------------------------
3
PsiBlast_PDB
65.89
23%
38
- C5 -
-
2PPQ
-
KHSE_AGRFC
A:
[16-311]
-------------------------------------------------------------
L
T
Q
Y
D
V
GSLT
S
-
Y
-
K
G
I
---
A
E
------
N
-----
S
--
N
F
L
----
L
H
T
-
T
---
K
D
-
P
---------
L
I
L
T
L
----
Y
EK-----------
K
----
N
D
---
L
-
P
F
F
L
G
L
M
Q
H
L
A
A
-
K
G
------
L
-
S
-
C
P
L
P
--
L
P
R
K
D
G
E
--
L
L
G
E
----
L
-
S
G
R
P
-------
A
A
L
I
S
F
L
E
G
M
W
---
L
--------
R
--
K
---
P
---
E
A
K
H
C
R
E
V
G
K
A
L
A
A
M
H
L
A
S
--
E
G
F
E
----
I
K
------
R
P
N
A
L
---
S
V
----
D
G
W
K
V
L
--
W
D
K
S
E
E
R
--
A
D
E
V
E
K
------
G
L
R
-
E
E
I
R
P
E
I
----
D
Y
L
A
A
H
W
P
------------------------------
K
D
---
L
------
P
--------------
A
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
-
L
G
----
D
ELS
G
-
L
-
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
-------
L
N
--
A
--------------
W
C
-
F
--------------
E
----------------
K
----------
D
--
G
A
Y
N
-
V
T
K
G
K
A
---
L
L
E
G
Y
-
Q
S
--
V
R
------
P
L
S
E
A
E
L
E
A
-------
L
------
P
L
--------------
L
S
R
G
S
A
L
R
F
F
L
---
T
R
L
Y
D
----
W
L
---
T
---------
T
P
A
G
A
L
V
V
K
K
D
P
L
---
E
Y
L
R
K
L
R
F
H
R
T
I
--------------------
24
HHSearch
60.05
20%
8
- C5 -
-
2PPQ
-
KHSE_AGRFC
A:
[10-273]
----------------------------------------------------
D
E
---
L
R
N
F
L
T
Q
Y
D
V
----
G
S
L
-
T
S
Y
---
K
G
I
AE---
N
-----
S
--
N
F
L
----
L
H
T
-
T
---
K
D
-
P
---------
L
I
L
T
L
----
Y
--
E
K
---------
K
----
N
D
---
L
-
P
F
F
L
G
L
M
Q
H
L
A
A
-
K
G
------
L
-
S
-
C
P
L
P
--
L
P
R
K
D
G
E
L
-
L
G
E
L
----
S
-
G
R
P
A
-------
A
L
I
S
F
L
E
G
M
W
L
---
R
--------
K
--
P
---
E
---
A
K
H
C
R
E
V
G
-
K
A
L
A
A
M
H
L
A
S
--
E
G
F
E
----
I
K
------
R
P
N
-----
A
L
S
V
--
D
G
W
K
V
L
--
W
D
K
------
S
E
E
R
A
D
------
E
V
--------------------
E
K
---
G
L
--
R
E
E
I
R
P
E
I
D
Y
----------
L
-
A
A
---
H
------
W
P
------
K
D
L
P
---
A
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
-
L
G
D---
E
---
L
-
S
-
G
L
I
D
F
Y
-
F
A
C
N
D
L
L
A
Y
D
V
-------
S
I
C
L
N
--------------
A
W
-
C
--------------
F
----------------
E
----------
K
DG
A
-
Y
N
-
V
T
K
G
K
A
---
L
L
E
G
Y
-
Q
S
--
V
R
------
P
L
S
E
A
E
L
E
A
-------
L
------
P
L
L
-------------
S
R
G
S
A
---------------------------------------------------------------------------------
55
Fugue
53.15
12%
-58
- C5 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
----------------
S
A
--
F
--
T
F
Q
T
L
H
P
------
D
T
I
M
D
A
L
F
E
H
G
----
I
R
V
---
D
S
G
L
T
P
L
N
S
Y
----
E
-
N
-
R
V
Y
---
Q
F
Q
-----
D
-----
E
--
D
-------
R
R
-
R
---
F
V
-
V
---------
K
F
Y
R
P
----
E
--
R
W
----
T
----
A
----
D
Q
---
I
-
L
E
E
H
Q
F
A
L
Q
L
V
N
-
D
E
------
V
-
P
-
V
A
A
P
--
V
A
F
N
G
Q
T
L
L
N
H
Q
G
-------
F
Y
F
-------
A
V
F
P
S
V
G
G
R
Q
F
---
E
--------
A
--
D
---
N
---
I
D
Q
M
E
A
V
G
-
R
Y
L
G
R
M
H
Q
T
G
--
R
K
Q
L
----
F
-------------------------------
I
H
R
P
T
--
I
G
L
N
E
Y
------
L
I
E
P
R
K
L
F
E
D
A
----
T
L
I
P
S
G
L
K
A
---
A
F
--
L
K
A
T
D
E
L
I
A
A
----------
V
-
T
A
---
H
------
W
R
------
E
D
F
T
---
V
L
R
L
H
G
D
C
H
A
G
N
I
L
W
--
R
----
D
---
G
-
P
-
M
F
V
D
L
D
-
D
A
R
N
G
P
A
V
Q
D
L
-------
W
M
L
L
N
--------------
G
D
-
K
--------------
A
----------------
E
----------
Q
--
R
-
M
Q
-
L
E
T
I
I
E
---
A
Y
E
E
F
-
S
E
--
F
D
------
T
A
E
I
G
L
I
E
P
-------
L
------
R
A
M
-------------
R
L
V
Y
Y
L
A
W
L
M
R
R
WA
D
P
A
F
P
K
N
F
P
W
L
---
T
-----
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
E
P
P
L
Q
L
T
P
M
Y
----------------------
27
HHSearch
48.35
13%
32
- C5 -
-
4WH3
8
NAHK_BIFL2
A:
[7-298]
-----------------------------------------------------
V
---
L
F
G
I
A
S
H
F
A
L
EG--
A
-
V
-
T
G
I
---
E
P
Y
-----
G
DGHI
N
T
--
T
Y
L
----
V
T
T
-
D
---
G
P
-
R
---------
Y
I
L
Q
Q
----
M
--
N
T
----
S
----
I
FPD
T
V
N
L
--
M
-
R
N
V
E
L
V
T
S
T
L
K
A
-
Q
G
------
K
-
E
-
T
L
D
I
--
V
P
T
T
S
G
A
T
-
W
A
E
I
----
D
-
G
G
A
W
-------
R
V
Y
K
F
I
E
H
T
V
S
---
Y
NL------
V
--
P
---
N
---
P
D
V
F
R
E
A
G
-
S
A
F
G
D
F
Q
N
F
L
--
S
E
F
D
----
A
S
------
Q
L
T
E
T
---
I
A
H
F
--
H
D
T
P
H
R
--
F
E
D
F
K
A
A
---------------
L
A
A
-
D
K
L
G
R
A
----
A
A
-
C
Q
P
E
I
D
---
F
Y
--
L
S
H
A
D
Q
Y
A
V
V
----------
M
-
D
G
---
L
------
R
D
------
G
S
I
P
---
L
R
V
T
H
N
D
T
K
L
N
N
I
L
M
-
D
A
TTG-
K
---
A
-
R
-
A
I
I
D
L
D
-
T
I
M
P
G
S
M
L
F
D
F
-------
G
D
S
I
R
--------------
F
G
-
A
--------------
S
----------------
T
ALEDEKDLSK
V
--
H
-
F
S
-
T
E
L
F
R
A
---
Y
T
E
G
F
-
V
G
E
L
R
G
------
S
I
T
A
R
E
A
E
L
-------
L
------
P
F
S
-------------
G
N
L
-----------------------------------------------------------------------------------
67
Fugue
48.31
17%
-1
- C3 -
-
4N0N
-
A:
[22-422]
---------------
S
A
V
--
C
--
T
V
C
G
A
A
----------
P
V
A
K
S
A
C
G
G
W
F
C
G
N
C
---
V
P
Y
H
A
G
H
C
H
T
----
T
-
S
-
L
F
A
---
N
C
G
-----
H
-----
D
--
I
M
Y
RSTY
C
T
M
-
C
---
E
G
-
S
---------
P
K
Q
M
V
----
P
--
K
V
----
P
----
H
----
P
I
---
L
-
D
H
L
L
C
H
I
D
Y
G
S
K
-
E
E
------
L
-
T
-
L
V
V
A
DG
R
T
T
S
P
P
G
R
Y
K
V
G
H
----
K
-
V
V
A
V
V
A
D
VG
G
N
I
V
F
G
C
G
P
G
S
H
I
---
A
--------
V
--
P
---
L
---
Q
D
T
L
K
G
V
V
-
V
N
K
A
L
K
N
A
A
A
--
S
E
Y
V
E
G
P
P
G
S
G
K
T
F
H
L
V
K
D
V
L
---
A
V
V
G
--
S
A
T
L
V
V
PT
H
A
S
M
L
D
C
--
I
N
K
L
K
Q
A
G
A
D
P
Y
F
V
V
P
K
Y
T
V
L
D
F
P
R
PG
S
G
N
I
T
V
R
L
P
---
Q
---
V
G
T
S
E
G
E
T
F
V
D
EVAYFS
P
V
D
L
-
A
R
---
I
------
L
T
------
Q
G
R
V
---
K
G
Y
--
G
D
L
N
Q
L
G
C
V
G
-
P
A
----
S
---
V
-
P
-
R
N
L
W
L
R
-
H
F
V
S
L
E
P
L
R
V
C
-------
H
R
F
G
A
--------------
A
V
-
C
--------------
D
L
I
K
GIYPY
Y
E
P
A
P
H
T
T
K
----------
V
--
V
-
F
V
-
P
N
P
D
F
E
K
G
V
V
I
T
A
Y
-
H
K
--
D
R
------
G
L
G
H
R
T
I
D
S
-------
I
QGCTFP
V
V
T
-------------
L
R
L
P
T
P
---------
Q
S
L
T
R
P
R
A
V
V
---
A
--------
V
T
R
A
S
Q
E
L
Y
I
Y
D
P
F
---
D
Q
L
S
G
L
L
K
F
-----------------------
25
HHSearch
47.91
18%
48
- C5 -
-
6EF6
2
?
A:
[30-313]
-----------------------------------------------------
I
---
A
Q
Q
A
L
T
H
Y
D
V
----
S
-
D
N
A
S
L
---
R
L
L
-----
N
LSE
N
-
A
--
T
Y
L
----
V
E
D
-
G
---
E
H
-
Q
---------
S
I
L
R
V
----
H
--
R
Q
----
D
YHQ-
P
----
H
E
---
I
-
E
S
E
L
D
W
L
A
A
L
R
T
D
S
D
------
V
-
T
-
V
P
T
V
--
V
P
A
R
D
G
R
R
-
V
V
T
V
D
P
A
D
V
-
P
R
H
V
-------
V
H
F
E
M
V
G
G
A
E
P
---
D
--------
E
ES
L
---
T
---
L
D
D
F
Q
T
L
G
-
R
I
T
A
S
L
H
E
H
S
--
Q
R
W
T
----
R
P
------
A
G
F
-----------
G
R
F
S
W
D
--
W
E
H
C
L
G
D
--
T
P
R
W
G
R
------
W
Q
D
A
-
E
G
V
G
A
S
----
E
---
T
A
L
L
T
---
R
A
--
Q
D
L
L
H
R
---
K
----------
L
-
E
E
---
Y
------
G
S
------
G
P
D
R
---
Y
G
L
I
H
A
D
L
R
L
A
N
L
L
V
-
D
S
STPQ
R
---
T
-
I
-
T
V
I
D
F
D
-
D
C
G
F
G
W
Y
F
Y
D
F
-------
G
T
A
V
S
--------------
F
I
-
E
--------------
H
----------------
D
-------------
P
-
R
L
-
G
E
W
Q
E
S
---
W
V
A
G
Y
-
R
S
--
R
R
------
E
L
P
A
A
D
E
A
M
-------
L
------
P
S
F
-------------
V
F
L
R
R
L
L
-------------------------------------------------------------------------------
58
Fugue
47.21
11%
42
- C5 -
-
2QG7
-
?
A:
[50-458]
YPITESNLRILEGED
R
S
E
--
K
--
A
K
E
L
L
K
K
Y
VSNVF
E
N
E
K
T
L
Y
I
Y
C
K
Y
V
M
L
H
Y
G
---
K
D
L
V
N
P
N
E
V
D
----
S
-
L
-
E
F
Q
---
I
I
N
-----
G
-----
T
--
N
I
L
----
I
K
V
-
K
DMS
K
Q
-
A
---------
K
Y
L
I
R
----
L
--
Y
G
----
P
----
T
----
D
E
IIN
R
-
E
R
E
K
K
I
S
C
I
L
Y
N
-
K
N
------
I
-
A
-
K
K
I
Y
--
V
F
F
T
N
G
------------------------
R
I
E
E
F
M
D
G
Y
A
L
---
S
--------
R
--
E
---
D
I
K
N
P
K
F
Q
K
L
I
A
-
K
N
L
K
L
L
H
D
I
K
LN
E
N
L
Y
----
K
E
------
L
Q
V
T
Q
---
K
V
P
G
--
T
R
P
S
F
L
--
W
N
T
I
W
K
Y
--
F
H
L
L
N
E
------
E
R
K
K
I
C
S
F
D
A
K
----
A
N
I
L
K
L
--
I
---
D
F
--
D
V
L
R
D
S
I
V
E
V
----------
E
-
S
L
---
C
------
K
R
------
E
N
S
P
---
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
-
T
V
GE
G
-
D
---
S
-
I
-
S
F
I
D
F
E
-
Y
S
C
P
M
E
R
A
Y
D
I
-------
A
N
H
F
N
--------------
E
Y
-
A
GFNCD---------
W
----------------
D
----------
L
--
T
-
P
S
-
K
E
E
E
Y
H
---
F
I
M
H
Y
-
L
G
--
T
D
--------
D
E
E
L
I
N
Q
-------
L
------
I
R
E
-------------
I
----
Q
P
F
Y
I
C
---
S
H
I
N
W
G
L
W
S
L
L
---
Q
-----
G
M
H
--
S
F
D
F
I
N
Y
G
M
T
R
L
---
T
A
S
C
L
P
I
F
R
S
K
V
--------------------
26
HHSearch
46.91
13%
30
- C5 -
-
4OCV
2
?
A:
[25-320]
---------------------------------------------------
N
E
A
---
L
F
D
V
A
S
H
F
A
L
EG--
T
-
V
-
D
S
I
---
E
P
Y
-----
G
DGH
I
N
T
--
T
Y
L
----
V
T
T
-
D
---
G
P
-
R
---------
Y
I
L
Q
R
----
M
--
N
T
----
G
----
I
FPD
T
V
N
---
L
M
R
N
V
E
L
V
T
S
T
L
K
A
-
Q
G
------
K
-
E
-
T
L
D
I
--
V
R
T
T
S
G
D
T
-
W
A
E
I
----
D
-
G
G
A
W
-------
R
V
Y
K
F
I
E
H
T
M
S
---
Y
NL------
V
--
P
---
N
---
P
D
V
F
R
E
A
G
-
R
A
F
G
D
F
Q
N
F
L
--
S
G
F
D
----
A
N
------
Q
L
T
E
T
---
I
A
H
F
--
H
D
T
P
H
R
--
F
E
D
F
K
K
A
--
L
A
A
D
--------
E
L
G
R
---
A
A
G
C
--------
G
P
E
I
E
---
F
Y
--
L
S
H
A
D
Q
Y
A
V
V
----------
M
-
D
G
---
L
------
R
D
------
G
S
I
P
---
L
R
V
T
H
N
D
T
K
L
N
N
I
L
M
-
D
A
TTG-
K
---
A
-
R
-
A
I
I
D
L
D
-
T
I
M
P
G
S
M
L
F
D
F
-------
G
D
S
I
R
--------------
F
G
-
A
--------------
S
----------------
T
ALEDERDLDK
V
--
H
-
F
S
-
T
E
L
F
R
A
---
Y
T
E
G
F
-
V
G
E
L
R
D
------
S
I
T
A
R
E
A
E
L
-------
L
------
P
F
S
-------------
G
N
L
L
T
---------------------------------------------------------------------------------
28
HHSearch
46.79
15%
52
- C5 -
-
1ZYL
-
SRKA_ECOLI
A:
[13-274]
---------------------------------------------------
P
D
T
---
I
M
D
A
L
F
E
H
G
I
----
R
-
V
D
S
G
L
---
T
P
L
-----
N
S
YE
N
-
R
--
V
Y
Q
----
F
Q
D
-
E
D--
R
R
-
R
---------
F
V
V
K
F
----
Y
--
R
P
----
E
RWT-
A
----
D
Q
---
I
-
L
E
E
H
Q
F
A
L
Q
L
V
N
-
D
E
------
V
-
P
-
V
A
A
P
--
V
A
-
F
N
G
Q
T
-
L
L
N
H
----
Q
-
G
F
Y
F
-------
A
V
F
P
S
V
G
G
R
Q
F
---
E
--------
A
--
D
---
N
---
I
D
Q
M
E
A
V
G
-
R
Y
L
G
R
M
H
Q
T
G
--
R
K
Q
L
----
F
I
------
H
R
P
-----
T
I
G
L
--
N
E
Y
L
I
E
--
P
R
K
L
F
E
D
---------------
A
T
L
--
I
P
S
G
L
----
K
-------
A
---
A
F
--
L
K
A
T
D
E
L
I
A
A
----------
V
-
T
A
---
H
------
W
R
------
E
D
F
T
---
V
L
R
L
H
G
D
C
H
A
G
N
I
L
W
-
R
D
--------
G
-
P
-
M
F
V
D
L
D
-
D
A
R
N
G
P
A
V
Q
D
L
-------
W
M
L
L
N
--------------
G
D
-
K
--------------
A
----------------
E
----------------
Q
-
R
M
Q
L
E
T
---
I
I
E
A
Y
-
E
E
--
F
S
------
E
F
D
T
A
E
I
G
L
-------
I
------
E
P
L
-------------
R
A
M
R
L
---------------------------------------------------------------------------------
64
Fugue
46.15
13%
10
- C5 -
-
3I1A
2
?
A:
[3-330]
---------------------------
K
Q
P
------
I
Q
A
Q
Q
L
I
E
L
L
K
V
H
Y
G
I
D
--------
I
H
T
A
Q
F
----
I
-
Q
-
G
G
A
---
D
T
N
-----
A
-----
F
--
A
Y
Q
----
A
D
S
-
E
---
S
K
-
S
---------
Y
F
I
K
L
----
K
--
Y
G
----
Y
----
H
----
D
E
---
I
-
N
L
S
I
I
R
L
L
H
D
S
G
-
I
K
------
E
---
I
I
F
P
--
I
H
T
L
E
A
K
L
F
Q
Q
L
K
----
H
--
F
K
I
-------
I
A
Y
P
F
I
H
A
P
N
G
---
F
--------
T
--
Q
---
N
L
T
-
G
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
I
H
E
T
S
--
V
P
I
S
----
I
Q
------
Q
Q
L
R
K
---
E
I
Y
S
-----
P
K
W
--
R
E
I
V
R
S
F
--
Y
N
Q
I
E
F
------
D
N
S
D
D
K
L
T
A
A
F
----
K
S
F
F
N
Q
N
S
A
---
A
I
--
H
R
L
V
D
T
S
E
K
L
----------
S
-
K
K
---
I
------
Q
P
------
D
L
D
K
---
Y
V
L
C
H
S
D
I
H
A
G
N
V
L
V
-
G
N
----
E
---
E
S
I
-
Y
I
I
D
W
D
-
E
P
M
L
A
P
K
E
R
D
L
MFIGGGV
G
N
V
W
N
--------------
K
P
-
H
--------------
E
----------------
I
----------
Q
--
Y
-
F
Y
-
E
G
Y
G
E
------
I
N
V
-
D
K
--
T
I
------
L
S
Y
Y
R
H
E
R
I
-------
V
------
E
D
I
-------------
A
V
Y
G
Q
D
L
L
S
-------------
R
N
Q
---
N
-----
N
Q
S
R
L
E
S
F
K
Y
F
K
E
M
F
D
P
---
N
N
V
V
E
I
A
F
A
T
E
---------------------
65
Fugue
45.16
11%
19
- C5 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
--------------G
M
K
E
--
L
L
S
T
M
D
L
D
T
D
------
A
N
T
I
P
E
L
K
E
R
A
H
M
L
C
A
R
F
LGG
A
W
K
T
V
P
L
E
H
L
----
R
-
I
-
S
R
I
---
K
G
G
-----
M
-----
S
--
N
M
L
----
F
L
C
-
R
L
--
S
E
-
V
---------
Y
P
P
I
R
----
N
--
E
P
----
N
----
K
----
V
L
---
L
-
R
V
Y
F
N
P
E
T
E
S
H
L
-
V
A
------
E
-
S
-
V
I
F
T
--
L
L
S
E
R
H
L
G
P
K
L
Y
G
----
I
-
F
S
G
G
-------
R
L
E
E
Y
I
P
S
R
P
L
S
C
H
E
--------
I
--
S
---
L
---
A
H
M
S
T
K
I
A
-
K
R
V
A
K
V
H
Q
L
E
--
V
P
I
W
----
K
E
------
P
D
Y
L
C
---
E
A
L
Q
--
R
W
L
K
Q
L
--
T
G
T
V
D
--------------------
A
E
H
R
F
D
L
----
P
E
E
C
G
V
S
S
V
---
N
C
--
L
D
L
A
R
E
L
E
F
L
----------
R
-
A
H
---
I
------
S
L
------
S
K
S
P
---
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
-
P
K
----
R
-----
L
-
V
L
I
D
F
E
-
Y
A
S
Y
N
Y
R
A
F
D
F
-------
A
N
H
F
I
E
W
T
IDYDIDEAPF
Y
K
I
-
Q
--------------
T
----------------
E
----------
N
--
F
-
P
E
-
N
D
Q
M
L
E
---
F
F
L
N
Y
L
R
E
--
Q
G
------
N
T
R
E
N
E
L
Y
K
-------
K
------
S
E
D
-------------
L
V
Q
E
T
L
P
F
V
P
V
---
S
H
F
F
W
G
V
W
G
L
L
---
Q
-----
V
E
L
S
P
V
--
G
F
G
F
A
D
Y
G
R
---
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA---------------
59
Fugue
44.82
11%
20
- C5 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
---------------
K
T
P
--
L
--
Y
E
T
L
N
E
S
------
S
A
V
A
L
A
V
K
L
G
L
------------------
T
L
----
T
-
C
-
Q
E
I
---
G
D
G
-----
N
-----
L
--
N
Y
V
----
F
H
I
-
Y
---
D
R
-
A
---------
L
I
I
K
Q
----
A
--
V
P
YWPL
T
----
I
----
D
R
---
A
-
R
I
E
S
S
A
L
I
R
Q
G
E
-
H
V
------
P
-
H
L
V
P
R
V
--
F
Y
S
D
T
E
M
A
V
T
V
M
E
----
D
L
S
H
L
K
-------
I
A
R
K
G
L
I
E
G
E
N
---
Y
--------
P
--
H
---
L
---
S
Q
H
I
G
E
F
L
-
G
K
T
L
F
Y
S
S
D
Y
--
A
L
E
P
----
K
V
------
K
K
Q
L
V
---
K
Q
F
T
--
N
---
P
E
--
L
C
D
I
T
E
R
--
L
V
F
T
D
P
------
F
F
D
H
D
T
N
D
F
E
E
----
E
L
R
P
F
V
E
K
L
---
W
N
--
N
D
S
V
K
I
E
A
A
K
----------
L
-
K
K
---
S
------
F
L
------
T
S
A
E
----
T
L
I
H
G
D
L
H
T
G
S
I
F
A
-
S
E
----
H
---
E
-
T
-
K
V
I
D
P
E
-
F
A
F
Y
G
P
I
G
F
D
V
-------
G
Q
F
I
A
--------------
N
L
F
L
--------------
N
----------------
A
----------
L
--
S
-
R
D
-
G
A
D
R
E
P
---
L
Y
E
H
V
-
N
Q
--
V
W
------
E
T
F
E
E
T
F
S
E
-------
A
------
W
Q
K
DSLDVYANIDG
Y
L
T
D
T
L
S
H
I
F
E
E
A
---
I
G
F
A
G
C
E
L
I
R
R
---
T
IGLAH
V
A
D
L
D
T
I
V
P
F
D
K
R
I
G
R
K
---
R
L
A
L
E
T
G
T
A
F
I
E
KRSEFKT
I
T
D
V
I
E
L
F
K
L
L
V
K
43
SP3
44.28
11%
19
- C5 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
--------------G
M
K
E
L
L
S
--
T
M
D
L
D
T
D
------
A
N
T
I
P
E
L
K
E
R
A
H
M
L
C
A
R
F
---
L
G
G
A
W
K
T
V
P
L
----
E
-
H
-
L
R
I
---
S
R
I
K
G
G
MS
N
-----
M
--
L
F
L
----
C
R
L
-
S
---
E
V
-
Y
PPIRNEPN
K
V
L
L
R
V
----
Y
FN
P
E
----
T
----
E
----
S
H
---
L
-
V
A
E
S
V
I
F
T
L
L
S
E
-
R
H
------
L
---
G
P
K
L
--
Y
G
I
F
S
G
----------------
G
-------
R
L
E
E
Y
I
P
S
R
P
L
---
S
--------
C
--
H
E
I
S
L
---
A
H
M
S
T
K
I
A
-
K
R
V
A
K
V
H
Q
L
E
--
V
P
I
W
----
K
E
------
P
D
----------------------
Y
L
C
E
A
--
L
Q
R
W
L
K
------
Q
L
T
G
T
V
D
A
E
H
R
----
F
D
L
P
E
E
C
G
V
---
S
S
VN
C
L
D
L
A
R
E
L
E
F
----------
L
-
R
A
---
H
I
-----
S
L
------
S
K
S
P
---
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
-
P
-----
K
---
R
-
L
-
V
L
I
D
F
E
-
Y
A
S
Y
N
Y
R
A
F
D
F
-------
A
N
H
F
I
--------------
E
W
-
T
IDYDIDEAPF
Y
K
I
Q
T
----------------
E
----------
N
--
F
-
P
E
-
N
D
Q
M
L
E
---
F
F
L
N
Y
-
L
R
--
E
Q
GNTREN
E
L
Y
K
K
S
E
D
L
-------
V
------
Q
E
T
LPF----------
V
P
V
S
H
F
F
W
G
V
W
---
G
L
L
Q
V
E
L
S
P
V
G
FG
F
A
-----
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
---
K
N
L
A
----------------------------
29
HHSearch
43.60
14%
33
- C5 -
-
3I1A
4
?
B:
[14-272]
-----------------------------------------------------------
L
L
K
V
H
Y
G
I
----
D
-
I
-
H
T
A
---
Q
F
I
-----
Q
GGADT
N
A
F
A
Y
Q
----
A
D
S
-
E
---
S
K
-
S
---------
Y
F
I
K
L
----
K
--
Y
G
----
Y
----
H
----
D
------
E
I
N
L
S
I
I
R
L
L
H
D
-
S
G
------
I
-
K
E
I
I
F
P
--
I
H
T
L
E
A
K
L
-
F
Q
Q
L
----
K
-
H
F
K
I
-------
I
A
Y
P
F
I
H
A
P
N
G
---
F
--------
T
--
Q
N
L
-
T
---
G
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
I
H
E
T
S
--
V
P
I
S
----
I
Q
------
Q
Q
L
-------
R
K
--
E
I
Y
S
P
K
--
W
R
E
I
V
R
S
--
F
Y
N
---------
Q
I
E
F
D
N
S
D
D
K
L
----
T
A
A
F
K
S
F
F
N
Q
N
S
A
A
--
I
H
R
L
V
D
T
S
E
K
----------
L
S
K
K
---
I
------
Q
P
------
D
L
D
K
---
Y
V
L
C
H
S
D
I
H
A
G
N
V
L
V
-
G
N
E---
E
---
S
-
I
-
Y
I
I
D
W
D
-
E
P
M
L
A
P
K
E
R
D
L
-------
M
F
I
G
G
--------------
G
V
-
G
--------------
N
----------------
V
---------------
W
N
K
P
H
E
I
Q
Y
---
F
Y
E
G
Y
-
G
E
--
I
N
------
V
----------------------------------------------------------------------------------------------------------------------------
66
Fugue
42.99
11%
6
- C5 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
--------------T
L
P
A
--
V
--
I
S
R
W
L
S
S
------
V
L
P
G
G
A
A
P
E
V
T
V
E
S
G
V
D
S
---
T
G
M
S
S
E
T
I
I
L
----
T
-
A
-
R
W
Q
Q
DG
R
S
I
-----
Q
-----
Q
--
K
L
V
----
A
R
V
-
A
---
P
A
-
A
---------
E
D
V
P
V
----
F
--------
P
----
T
----
Y
R
---
L
-
D
H
Q
F
E
V
I
R
L
V
G
E
-
L
T
DVPVPR
V
-
R
-
W
I
E
T
--
T
G
D
V
L
G
T
P
F
F
L
M
D
----
Y
-
V
E
G
V
-------
V
P
P
D
V
M
P
Y
T
F
G
---
D
NWFADAP
A
E
--
R
---
Q
---
R
Q
L
Q
D
A
T
V
-
A
A
L
A
T
L
H
-
S
I
--
P
N
A
Q
----
N
T
------
F
S
F
L
T
---
D
T
---------
T
--
L
H
R
H
F
N
W
--
V
R
S
W
Y
D
------
F
A
V
E
G
I
G
R
S
P
L
----
L
E
R
T
F
E
W
L
Q
---
S
H
--
W
P
D
D
A
A
A
R
E
P
----------------------------------------
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
F
----
Q
---
P
-
V
-
A
V
L
D
W
E
-
M
V
A
L
G
P
R
E
L
D
V
-------
A
W
M
I
F
--------------
A
H
-
R
--------------
V
----------------
F
----------
Q
--
E
-
L
A
-
G
L
A
T
L
P
---
G
L
P
E
V
-
M
R
--
E
D
------
D
V
R
A
T
Y
Q
A
L
TG
V
E
L
G
D
L
------
H
W
F
-------------
Y
V
Y
S
--
G
V
M
W
A
---
C
V
F
M
R
T
G
A
R
R
V
---
H
-----
F
G
E
I
E
K
P
D
D
V
E
S
L
F
Y
H
A
---
G
L
M
K
H
L
L
G
E
E
H
---------------------
45
SP3
41.03
12%
37
- C5 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
----------------------------------------------
A
K
M
R
I
S
P
E
---
L
K
K
L
I
E
K
Y
R
C
----
V
-
K
-
D
T
E
---
G
M
S
-----
P
-----
A
K
-
V
Y
K
----
L
V
G
-
E
---
N
E
-
N
---------
L
Y
L
K
M
T
D
SR
Y
--
K
G
----
T
----
T
----
Y
D
---
V
-
E
R
E
K
D
M
M
L
W
L
E
--
G
K
------
L
-
P
-
V
P
K
V
--
L
H
F
E
R
H
-----------
D
-
G
W
S
N
-------
L
L
M
S
E
A
D
G
V
L
C
S
E
-
E
--------
Y
--
E
---
D
---
E
Q
S
P
E
K
I
I
-
E
L
Y
A
E
C
I
R
L
F
--
H
S
I
D
----
I
S
------
D
C
P
Y
T
---
N
S
------------
L
D
S
R
L
A
E
--
L
D
Y
L
L
N
------
N
D
L
A
D
V
D
C
E
N
W
----
E
E
------
D
---
T
P
--
F
K
D
P
R
E
L
Y
D
F
----------
L
-
K
T
---
E
------
K
P
------
E
E
-
E
---
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
-
K
D
----
G
---
K
-
V
S
G
F
I
D
L
G
-
R
S
G
R
A
D
K
W
Y
D
I
-------
A
F
C
V
R
--------------
S
I
-
R
--------------
E
----------------
D
----------
I
--
G
--
E
-
E
Q
Y
V
E
L
---
F
F
D
L
L
-
G
-------------
I
K
P
D
W
E
K
-------
I
------
K
Y
Y
-------------
I
L
L
D
E
L
F
-------------------------------------------------------------------------------
41
HHSearch
40.90
15%
18
- C5 -
-
3F7W
7
?
A:
[7-263]
----------------------------------------------------------
A
R
V
T
E
L
T
G
R
----
E
-
V
-
A
A
V
---
A
E
R
-----
G
HSHR
W
H
--
L
Y
R
----
V
E
L
-
A
---
D
G
T
P
---------
L
F
V
K
A
----
L
--
P
D
----
D
APAL
D
----
G
L
---
F
-
R
A
E
A
L
G
L
D
W
L
G
R
-
S
F
G-----
S
-
P
-
V
P
Q
V
--
A
G
W
D
----------------
D
R
T
-------
L
A
M
E
W
V
D
E
R
P
P
---
T
-------------------
P
E
A
A
E
R
F
G
-
H
Q
L
A
A
M
H
L
A
G
--
A
E
S
F
----
G
A
------
T
W
D
G
Y
IGP
L
P
M
D
--
N
T
P
R
S
T
--
W
P
E
F
Y
A
E
QR
I
L
P
Y
L
R
------
R
A
A
D
---
R
G
A
L
-----------
T
P
---
G
D
--
V
R
L
V
E
K
V
L
D
A
----------
L
-
D
H
---
L
------
A
G
------
D
P
E
P
---
P
A
R
I
H
G
D
L
W
N
G
N
V
L
W
-
Q
D
----
D
---
G
-
A
-
V
V
I
D
P
A
--
A
H
G
G
H
R
E
A
D
L
-------
A
M
L
A
L
--------------
F
G
----------------------------------------------------
L
P
Y
L
D
R
---
V
R
D
A
Y
-
N
E
--
V
A
------
P
L
A
E
G
W
R
A
R
-------
I
------
P
L
H
-------------
Q
L
H
P
L
---------------------------------------------------------------------------------