@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : D4YZ71_SPHJU: (2019-01-27 )
MPSHLTHIWRLLKWGRTLARHGALTGIERDPLTPTPVRRLVRVARLGARVPRQPRYADAFQSIGPAAIKLGQTLATRPDLVGEDAANDLLRLQDALPPVPFATIRAQMEQSFGRPLETLYSRFDEAPVGAASIAQVHRAVTTDGRDVAVKVIRPGVIDQFNRDIQTYEWAAAHVEMLGGEVARLRPRLVIANMKRWTARELDLRREAASASELGEAMEAMPGYRVPAIDWDRTTGKVMTMEWIDGVKISDRDALIAAGHDVKEIAARLVNAFLRQAIAEGFFHADMHQGNLFVTANGDIVAIDFGIMGRIDRRARMWLAEILYGLITGNYRRVAEIHFEAQYVPGHHNVEEFATALRAVGEPMRGKPVRELSVGGMLDGLFAITRDFDMQTQPHLLLLQKTMVMVEGVATALDPDINLWETSGPYVKEWLRAELGPEAKAADALIENVRILQRLPGLVKRIEEAFPEKGGAPPPPPLTEVRLIRVGSGWRYMLVALLAGLAGAGAMAAATTFL
Atome Classification :
(23 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10.......-----.20...---.....30......--..40...--.....50........60...---------------------.....70..--.----....----.-80.........90.......---.100-..------.....110..-.....---120...-....130...-------....140-.-......--150.....-..160-----.......170.....--..180...-....190..----.....200---........210.-......------220---------.......230...--------------....240.......250......--.-.---.--260..-......-----.270..---...------..280..------.....290-..--.-..-..300......-..310......-.320.......330--------------.........------340----...--.---..--..350...---...-----.360--..-..-------.-------..--..370..-------.....380--.......390.----------....-..400----.......410.......420.-......430.....---------------..440.-.------.....450.-.-.....460--------.......-..470.-----......480..--.---....490.......500.......510.-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MP
S
H
L
T
H
I
W
R
L
L
K
W
G
R
T
L
-----
A
RHGAL---TGIERDPLT
P
T
P
V
--
R
R
L
V
R
V
A
--
R
L
G
ARVPRQP
R
Y
A
D
A
F
Q
SI
G
---------------------
P
A
A
I
KLG
Q
T
--L----ATRP----D-L-VG
E
D
A
A
N
D
L
L
R
L
Q
DALPP---V
P
F
A
-
T
I
------
R
A
Q
M
E
Q
S
FG
R
-
P
L
E
T
L
---
Y
S
RFDE-APV
G
A
A
S
I
A
Q
-------
V
H
R
A
VTT-D-G
R
D
V
A
V
--
K
V
IRP
G
V
I
-
D
Q
FNR-----DI
Q
T
Y
E
W
A
A
A
H
V
E
M
L--GG
E
V
A
R
LR-
P
R
L
V
I
ANMK----RW
T
A
R
E
L
----
D
L
R
R
EAA
S
A
S
E
L
-
G
E
A
M
E
A------MPG---------YRVPAIDWDRTT
G
--------------
K
V
M
T
M
E
WID
G
V
K
ISD--R
D
A
L
I
A--A-G---H--
D
--
V
K
-
E
I
A
A
R
L
-----
V
N
A
F
L
R
---
Q
A
I
------
A
E
G
F
F
H
A
------DMHQG
N
L
F
-
V
T--A-NG-
D
I
V
A
-
I
D
F
G
IM-G
R
I
D
R
R
A
R
M
W
L
-
A
E
I
L
Y
G
L
ITGN
Y
----------------
R
R
V
A
E
I
H
F
E
------
A
Q
-----YVP--G---HH--
N
V
E
E
F
A
T
A
---
L
R
A-----VG----EP-MR-------G-------KP--
V
R
ELSV
G
-------
G
M
L
D
G
L
F
A
--
I
T
RDFDMQTQP----------H
L
L
L
-
L
Q
K
T
M
----
V
M
V
E
G
V
A
T
ALDPDI
N
L
WETS
G
-
P
Y
V
K
E
W
L
R
A
ELGPE---------------
A
K
A
A
D
A
-
L
------
I
E
N
V
R
I
L
Q
R
-
L
-
P
G
L
V
K
R
----------
I
E
E
AFPE-KGGAPP-----PPPL
T
E
V
R
L
I
R
--V---GS
G
W
R
Y
M
L
V
A
L
L
A
G
LAGA
G
A
M
A
A
ATTFL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
87.24
22%
-8
- C6 -
-
4PED
-
COQ8A_HUMAN
A:
[4-389]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
A
E
R
I
V
R
T
L
C
K
V
R
---------------------
G
A
A
L
K
L
G
Q
M
--
L
----
S
I
Q
D
----
D
-
A
F
I
N
P
H
L
A
K
I
F
E
R
V
R
Q
S
A
D
F
---
M
P
L
K
-
Q
M
------
M
K
T
L
N
N
D
L
G
P
-
N
W
R
D
K
---
L
E
Y
F
E
E
-
R
P
F
A
A
A
S
I
G
Q
-------
V
H
L
A
R
M
K
-
G
-
G
R
E
V
A
M
--
K
I
Q
Y
P
G
V
A
-
Q
S
I
N
S
-----
D
V
N
N
L
M
A
V
L
N
M
S
N
M
L
-----
P
E
G
L
F
-
P
E
H
L
I
D
V
L
R
----
R
E
L
A
L
E
C
----
D
Y
Q
R
E
A
A
C
A
R
K
F
-
R
D
L
L
K
G
------
H
P
F
---------
F
Y
V
P
E
I
V
D
E
L
C
S
P
--------------
H
V
L
T
T
E
L
V
S
G
F
P
L
D
Q
--
A
E
G
L
----
S
-
Q
---
E
--
I
--
R
N
-
E
I
C
Y
N
I
-----
L
V
L
C
L
R
---
E
L
F
------
E
F
H
F
M
Q
T
------
D
P
N
W
S
N
F
F
-
Y
D
--
P
Q
Q
H
-
K
V
A
L
-
L
D
F
G
A
T
-
R
E
Y
D
R
S
F
T
D
L
Y
-
I
Q
I
I
R
A
A
A
D
R
D
R
----------------
E
T
V
R
A
K
S
I
E
------
M
K
-----
F
L
T
--
G
---
Y
---
E
V
K
V
M
E
D
A
H
L
D
A
I
L
-----
I
L
----
G
E
A
F
A
S------
D
-------
E
P
FD
F
G
T
Q
S
T
T
-------
E
K
I
H
N
L
I
P
--
V
M
L
R
H
R
L
V
P
P
P
----------
E
E
T
Y
S
L
H
R
K
M
----
G
G
S
F
L
I
C
S
K
L
K
A
R
F
P
C
K
A
M
F
E
-
E
A
Y
S
N
Y
C
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
74.12
22%
-4
- C6 -
-
5YK0
4
?
A:
[50-445]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
V
--
T
A
E
L
M
E
K
A
A
N
Q
L
F
T
V
L
G
E
L
K
---------------------
G
G
A
M
K
V
G
Q
A
--
L
----
S
V
M
E
A
A
I
P
D
-
E
-
F
G
E
P
Y
R
E
A
L
T
K
L
Q
K
D
A
P
P
---
L
P
A
S
-
K
V
------
H
R
V
L
D
G
Q
L
G
T
-
K
W
R
E
R
---
F
S
S
F
N
D
-
T
P
V
A
S
A
S
I
G
Q
-------
V
H
K
A
I
W
S
-
D
-
G
R
E
V
A
V
--
K
I
Q
Y
P
G
A
D
-
E
A
L
R
A
-----
D
L
K
T
M
Q
R
M
V
G
V
L
K
Q
L
-----
S
P
G
A
D
-
V
Q
G
V
V
D
E
L
V
----
E
R
T
E
M
E
L
----
D
Y
R
L
E
A
A
N
Q
R
A
F
-
A
K
A
Y
H
D
------
H
P
R
---------
F
Q
V
P
H
V
V
A
--
S
A
P
--------------
K
V
V
I
Q
E
W
I
E
G
V
P
M
A
E
--
I
I
R
H
G
---
T
-
T
---
E
--
Q
--
R
D
-
L
I
G
T
L
L
-----
A
E
L
T
F
D
---
A
P
R
------
R
L
G
L
M
H
G
------
D
A
H
P
G
N
F
M
-
L
L
--
P
-
D
G
-
R
M
G
I
-
I
D
F
G
A
V
-
A
P
M
P
G
G
F
P
I
E
L
-
G
M
T
I
R
L
A
R
E
K
N
Y
----------------
D
L
L
L
P
T
M
E
K
------
A
G
-----
L
I
Q
--
R
---
G
R
QV
S
V
R
E
I
D
E
M
---
L
R
Q
-----
Y
V
----
E
P
-
I
Q
-------
V
E
V
F
H
Y
T
R
K
W
--
L
Q
K
M
T
V
S
-------
Q
I
D
R
S
V
A
Q
--
I
R
T
A
R
Q
M
D
L
P
A
----------
K
L
A
I
-
P
M
R
V
I
----
A
S
V
G
A
I
L
C
Q
L
D
A
H
V
P
I
K
A
L
S
E
-
E
L
I
P
G
F
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
73.72
22%
-2
- C6 -
-
5YK1
2
?
A:
[48-445]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
D
E
V
--
T
A
E
L
M
E
K
A
A
N
Q
L
F
T
V
L
G
E
L
K
---------------------
G
G
A
M
K
V
G
Q
A
--
L
----
S
V
M
E
A
A
I
P
D
-
E
-
F
G
E
P
Y
R
E
A
L
T
K
L
Q
K
D
A
P
P
---
L
P
A
S
-
K
V
------
H
R
V
L
D
G
Q
L
G
T
-
K
W
R
E
R
---
F
S
S
F
N
D
-
T
P
V
A
S
A
S
I
G
Q
-------
V
H
K
A
I
W
S
-
D
-
G
R
E
V
A
V
--
K
I
Q
Y
P
G
A
D
-
E
A
L
R
A
-----
D
L
K
T
M
Q
R
M
V
G
V
L
K
Q
L
-----
S
P
G
A
D
-
V
Q
G
V
V
D
E
L
V
----
E
R
T
E
M
E
L
----
D
Y
R
L
E
A
A
N
Q
R
A
F
-
A
K
A
Y
H
D
------
H
P
R
---------
F
Q
V
P
H
V
V
A
--
S
A
P
--------------
K
V
V
I
Q
E
W
I
E
G
V
P
M
A
E
--
I
I
R
H
G
---
T
-
T
---
E
--
Q
--
R
D
-
L
I
G
T
L
L
-----
A
E
L
T
F
D
---
A
P
R
------
R
L
G
L
M
H
G
------
D
A
H
P
G
N
F
M
-
L
L
--
P
-
D
G
-
R
M
G
I
-
I
D
F
G
A
V
-
A
P
M
P
G
G
F
P
I
E
L
-
G
M
T
I
R
L
A
R
E
K
N
Y
----------------
D
L
L
L
P
T
M
E
K
------
A
G
-----
L
I
Q
--
R
---
G
R
QV
S
V
R
E
I
D
E
M
---
L
R
Q
-----
Y
V
----
E
P
-
I
Q
VE
V
F
H
Y
T
R
-------
K
W
--
L
Q
K
M
T
V
S
-------
Q
I
D
R
S
V
A
Q
--
I
R
T
A
R
Q
M
D
L
P
A
----------
K
L
A
I
-
P
M
R
V
I
----
A
S
V
G
A
I
L
C
Q
L
D
A
H
V
P
I
K
A
L
S
E
-
E
L
I
P
G
F
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
64.18
31%
-24
- C6 -
-
5YJZ
2
?
A:
[75-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
K
V
G
Q
A
--
L
S
V
M
E
A
A
I
P
----
D
-
E
-
F
G
E
P
Y
R
E
A
L
T
K
L
Q
K
D
A
P
P
---
L
P
A
S
-
K
V
------
H
R
V
L
D
G
Q
L
G
T
-
K
W
R
E
R
---
F
S
S
F
N
D
-
T
P
V
A
S
A
S
I
G
Q
-------
V
H
K
A
I
W
S
-
D
-
G
R
E
V
A
V
--
K
I
Q
Y
P
G
A
D
-
E
A
L
R
A
-----
D
L
K
T
M
Q
R
M
V
G
V
L
K
Q
L
SP
G
A
D
V
------
Q
G
V
V
D
E
L
V
----
E
R
T
E
M
E
L
----
D
Y
R
L
E
A
A
N
Q
R
A
F
-
A
K
A
Y
H
D
------
H
P
R
---------
F
Q
V
P
H
V
V
A
--
S
A
P
--------------
K
V
V
I
Q
E
W
I
E
G
V
P
M
A
E
I
I
R
H
G
T
T
E
--
Q
-
R
---
D
--
L
--
I
G
-
T
L
L
A
E
L
-----
T
F
D
A
P
R
---
R
L
---------
G
L
M
H
G
------
D
A
H
P
G
N
F
M
-
L
L
--
P
-
D
G
-
R
M
G
I
-
I
D
F
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
64.13
31%
-22
- C6 -
-
5YK1
2
?
A:
[75-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
K
V
G
Q
A
--
L
S
V
M
E
A
A
I
P
----
D
-
E
-
F
G
E
P
Y
R
E
A
L
T
K
L
Q
K
D
A
P
P
---
L
P
A
S
-
K
V
------
H
R
V
L
D
G
Q
L
G
T
-
K
W
R
E
R
---
F
S
S
F
N
D
-
T
P
V
A
S
A
S
I
G
Q
-------
V
H
K
A
I
W
S
-
D
-
G
R
E
V
A
V
--
K
I
Q
Y
P
G
A
D
-
E
A
L
R
A
-----
D
L
K
T
M
Q
R
M
V
G
V
L
K
Q
L
SP
G
A
D
V
------
Q
G
V
V
D
E
L
V
----
E
R
T
E
M
E
L
----
D
Y
R
L
E
A
A
N
Q
R
A
F
-
A
K
A
Y
H
D
------
H
P
R
---------
F
Q
V
P
H
V
V
A
--
S
A
P
--------------
K
V
V
I
Q
E
W
I
E
G
V
P
M
A
E
I
I
R
H
G
T
T
E
--
Q
-
R
---
D
--
L
--
I
G
-
T
L
L
A
E
L
-----
T
F
D
A
P
R
---
R
L
---------
G
L
M
H
G
------
D
A
H
P
G
N
F
M
-
L
L
--
P
-
D
G
-
R
M
G
I
-
I
D
F
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
63.88
31%
-26
- C6 -
-
5YK0
4
?
A:
[75-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
K
V
G
Q
A
--
L
S
V
M
E
A
A
I
P
----
D
-
E
-
F
G
E
P
Y
R
E
A
L
T
K
L
Q
K
D
A
P
P
---
L
P
A
S
-
K
V
------
H
R
V
L
D
G
Q
L
G
T
-
K
W
R
E
R
---
F
S
S
F
N
D
-
T
P
V
A
S
A
S
I
G
Q
-------
V
H
K
A
I
W
S
-
D
-
G
R
E
V
A
V
--
K
I
Q
Y
P
G
A
D
-
E
A
L
R
A
-----
D
L
K
T
M
Q
R
M
V
G
V
L
K
Q
L
SP
G
A
D
V
------
Q
G
V
V
D
E
L
V
----
E
R
T
E
M
E
L
----
D
Y
R
L
E
A
A
N
Q
R
A
F
-
A
K
A
Y
H
D
------
H
P
R
---------
F
Q
V
P
H
V
V
A
--
S
A
P
--------------
K
V
V
I
Q
E
W
I
E
G
V
P
M
A
E
I
I
R
H
G
T
T
E
--
Q
-
R
---
D
--
L
--
I
G
-
T
L
L
A
E
L
-----
T
F
D
A
P
R
---
R
L
---------
G
L
M
H
G
------
D
A
H
P
G
N
F
M
-
L
L
--
P
-
D
G
-
R
M
G
I
-
I
D
F
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
63.19
28%
2
- C6 -
-
5I35
1
COQ8A_HUMAN
A:
[19-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
K
L
G
Q
M
--
L
----
S
I
Q
D
----
D
A
F
-
I
N
P
H
L
A
K
I
F
E
R
V
R
Q
S
A
D
F
---
M
P
L
K
-
Q
M
------
M
K
T
L
N
N
D
L
G
P
-
N
W
R
D
K
---
L
E
Y
F
E
E
-
R
P
F
A
A
A
S
I
G
Q
-------
V
H
L
A
R
M
K
-
G
-
G
R
E
V
A
M
--
K
I
Q
Y
P
G
V
A
-
Q
S
I
N
S
-----
D
V
N
N
L
M
A
V
L
N
M
S
N
M
L
--
P
---
E
G
L
F
-
P
E
H
L
I
D
V
L
R
----
R
E
L
A
L
E
C
----
D
Y
Q
R
E
A
A
C
A
R
K
F
-
R
D
L
L
K
G
------
H
P
F
---------
F
Y
V
P
E
I
V
D
E
L
C
S
P
--------------
H
V
L
T
T
E
L
V
S
G
F
P
L
D
Q
--
A
E
G
L
------
S
---
Q
--
E
--
I
R
N
E
I
C
Y
N
I
-----
L
V
L
C
L
R
---
E
L
F
------
E
F
H
F
M
Q
T
------
D
P
N
W
S
N
F
F
-
Y
D
--
P
-
Q
Q
-
H
K
V
A
L
L
D
F
G
A
T
-
R
E
Y
D
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
63.08
31%
-26
- C6 -
-
5YK2
1
?
A:
[75-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
K
V
G
Q
A
--
L
S
V
M
E
A
A
I
P
----
D
-
E
-
F
G
E
P
Y
R
E
A
L
T
K
L
---
A
P
P
---
L
P
A
S
-
K
V
------
H
R
V
L
D
G
Q
L
G
T
-
K
W
R
E
R
---
F
S
S
F
N
D
-
T
P
V
A
S
A
S
I
G
Q
-------
V
H
K
A
I
W
S
-
D
-
G
R
E
V
A
V
--
K
I
Q
Y
P
G
A
D
-
E
A
L
R
A
-----
D
L
K
T
M
Q
R
M
V
G
V
L
K
Q
L
SP
G
A
D
V
------
Q
G
V
V
D
E
L
V
----
E
R
T
E
M
E
L
----
D
Y
R
L
E
A
A
N
Q
R
A
F
-
A
K
A
Y
H
D
------
H
P
R
---------
F
Q
V
P
H
V
V
A
--
S
A
P
--------------
K
V
V
I
Q
E
W
I
E
G
V
P
M
A
E
I
I
R
H
G
T
T
E
--
Q
-
R
---
D
--
L
--
I
G
-
T
L
L
A
E
L
-----
T
F
D
A
P
R
---
R
L
---------
G
L
M
H
G
------
D
A
H
P
G
N
F
M
-
L
L
--
P
-
D
G
-
R
M
G
I
-
I
D
F
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
62.48
28%
1
- C6 -
-
4PED
-
COQ8A_HUMAN
A:
[19-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
K
L
G
Q
M
--
L
----
S
I
Q
D
----
D
A
F
-
I
N
P
H
L
A
K
I
F
E
R
V
R
Q
S
A
D
F
---
M
P
L
K
-
Q
M
------
M
K
T
L
N
N
D
L
G
P
-
N
W
R
D
K
---
L
E
Y
F
E
E
-
R
P
F
A
A
A
S
I
G
Q
-------
V
H
L
A
R
M
K
-
G
-
G
R
E
V
A
M
--
K
I
Q
Y
P
G
V
A
-
Q
S
I
N
S
-----
D
V
N
N
L
M
A
V
L
N
M
S
N
M
L
--
P
---
E
G
L
F
-
P
E
H
L
I
D
V
L
R
----
R
E
L
A
L
E
C
----
D
Y
Q
R
E
A
A
C
A
R
K
F
-
R
D
L
L
K
G
------
H
P
F
---------
F
Y
V
P
E
I
V
D
E
L
C
S
P
--------------
H
V
L
T
T
E
L
V
S
G
F
P
L
D
Q
--
A
E
G
L
------
S
---
Q
--
E
--
I
R
N
E
I
C
Y
N
I
-----
L
V
L
C
L
R
---
E
L
F
------
E
F
H
F
M
Q
T
------
D
P
N
W
S
N
F
F
-
Y
D
--
P
-
Q
Q
-
H
K
V
A
L
L
D
F
G
A
T
-
R
E
Y
D
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
57.75
15%
-27
- C6 -
-
5CKW
1
?
B:
[6-410]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
K
L
L
R
F
---------------------------------------------------
H
E
--
L
----
K
S
L
P
----
G
-
M
-
D
E
K
A
L
E
L
L
I
K
V
L
G
N
----------
K
-
G
I
------
R
K
L
I
K
S
A
D
G
K
-
P
-------------------------------
I
S
R
E
I
M
I
-
H
-
E
F
G
I
D
C
--
Q
I
L
F
I
T
T
E
-
A
S
L
K
P
-----
I
I
V
P
T
E
N
K
I
S
Y
C
E
Q
F
--
K
V
Y
A
L
D
D
G
-
K
T
Y
F
L
K
S
V
K
----
I
D
A
E
S
L
T
----
E
F
T
N
E
K
D
T
L
S
K
L
-
G
R
----------
L
V
G
---------
T
F
F
N
----
E
Q
T
Q
V
--------------
H
Y
I
L
T
T
F
I
K
G
I
D
L
S
R
--
Y
K
N
A
L
P
--
L
-
N
---
V
--
N
--
L
K
-
H
F
W
E
V
L
G
I
M
I
S
V
C
H
Q
V
K
---
Q
F
H
------
E
L
G
L
I
H
R
------
D
L
K
P
G
N
I
M
-
L
D
--
A
-
D
M
-
Q
C
H
L
-
V
D
F
G
S
S
-
S
S
D
K
E
P
K
P
A
S
W
-
G
T
A
S
Y
------------------------
L
A
P
E
L
N
A
Q
------
E
D
-----
F
I
A
FS
Q
---
V
S
--
D
L
F
A
L
A
Y
S
---
L
D
E
-----
L
F
----
N
P
-
F
R
-------
Q
-------
V
K
--
F
A
K
V
D
I
G
IKNKHL
V
L
L
H
A
E
I
E
A
--
C
I
T
G
L
M
S
N
E
T
S
----------
V
R
T
L
-
Y
F
S
R
I
----
L
Q
L
Q
R
V
P
E
S
F
K
S
R
P
E
A
F
T
Y
L
I
-
M
L
L
T
Q
W
K
S
C
Y
E
A
P
E
M
--------------
N
K
E
L
D
E
-
I
------
I
A
E
I
K
V
A
Y
E
N
H
-
E
Q
D
A
V
K
----------
I
I
T
L
L
E
Q
-
L
S
K
A
D
----------------
G
--
L
---
L
N
S
H
K
A
L
L
S
V
L
I
K
S
L
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
54.82
18%
-11
- C8 -
-
4RIC
-
FAN1_HUMAN
A:
[1-631]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGHP
Y
Y
L
R
S
F
L
V
V
L
K
T
V
L
E
N
E
D
D
M
L
L
F
D
E
Q
E
K
G
I
V
---
T
K
F
Y
Q
--
L
S
A
T
G
Q
--
K
L
Y
V
R
L
F
Q
R
K
L
S
W
I
K
M
T
K
L
E
Y
E
E
I
A
L
D
L
T
---------------------
P
V
I
E
E
L
T
N
A
GF
L
----
Q
T
E
S
----
E
-
L
-
Q
E
L
S
E
V
L
E
L
L
S
A
P
E
L
K
S
L
---
A
K
T
F
-
H
L
VNPNGQ
K
Q
Q
L
V
D
A
F
L
K
-
L
A
K
Q
R
---
S
V
I
G
A
V
-
I
L
K
R
A
K
A
L
A
G
-------
Q
S
V
R
I
C
K
-
G
-
P
R
A
V
F
S
--
R
I
L
L
L
F
S
L
T
D
S
M
E
D
-----
E
D
A
A
C
G
G
Q
G
Q
L
S
T
V
L
--
L
V
N
L
G
R
M
E
F
P
S
Y
T
I
N
R
K
T
----
H
I
F
Q
D
R
D
----
D
L
I
R
Y
A
A
A
T
H
M
L
-
S
D
I
S
S
A
------
M
A
N
GN
W
E
E
A
K
E
L
A
Q
C
A
K
R
D
W
N
R
L
K
N
H
P
S
L
R
C
H
E
D
LP
L
F
L
R
C
F
T
V
G
W
I
Y
-
T
R
I
L
S
--
R
F
V
E
I
L
--
Q
-
R
---
L
--
H
--
M
Y
-
E
E
A
V
R
E
-----
L
E
S
L
L
S
---
Q
R
I
YCPDS
R
G
R
W
W
D
R
L
------
A
L
N
L
H
Q
H
L
-
K
R
--
L
-
E
P
-
T
I
K
C
-
I
T
E
G
L
A
D
P
E
V
R
T
G
H
R
L
S
L
-
Y
Q
R
A
V
R
L
R
E
S
P
S
CKKFKHLFQQLPEM
A
V
Q
D
V
K
H
V
T
I
T
------
G
R
L
CK
S
V
F
V
M
--
V
---
L
C
--
S
V
E
E
L
A
L
A
---
H
Y
R
R
S
GFD
Q
G
----
I
H
-
G
E
-------
G
-------
S
T
--
F
S
T
L
Y
G
L
-------
L
L
W
D
I
I
F
M
DG
I
P
D
V
F
R
N
A
C
Q
A
----------
F
P
L
D
-
L
C
-
T
D
----
S
F
F
T
S
R
R
P
A
L
E
A
R
L
Q
L
I
H
D
A
P
E
E
S
L
R
A
W
V
A
A
T
W
H
E
Q
EGRVASLVSWDRFTS
L
Q
Q
A
Q
D
-
L
------
V
S
C
L
G
-
G
P
V
-
L
-
S
G
V
C
R
H
----------
L
A
A
D
F
R
H
-
C
R
G
G
L
P
D
L
V
V
W
N
S
Q
S
R
H
F
K
L
V
E
--
V
K
G
P
N
D
R
L
S
H
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
E
V
C
H
V
V
A
V-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
54.70
15%
-58
- C7 -
-
3Q6K
2
?
A:
[1-380]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
T
Q
G
Y
K
W
K
Q
L
L
Y
N
N
V
T
-----
P
G
S
--------
Y
N
P
D
N
M
I
S
T
A
F
--
A
Y
D
A
E
G
E
--
K
L
F
L
A
V
P
R
K
L
P
R
V
-------------------------------------------------------------------------
P
---
Y
T
L
A
-
E
V
------
D
T
K
N
S
L
G
V
K
G
-
K
H
S
P
L
---
L
N
K
F
S
G
-
H
K
-
T
G
K
E
L
T
S
-------
I
Y
Q
-
P
V
I
-
D
-
D
C
R
-
R
L
--
W
V
V
D
I
G
S
V
-
E
Y
R
S
R
-----
G
A
K
D
Y
P
----------------
S
H
R
-
P
A
I
V
A
Y
D
L
K
----
Q
---
P
N
Y
----
P
E
V
V
R
Y
Y
F
P
T
R
L
-
V
E
K
P
T
Y
------
F
G
G
---------
F
A
V
D
V
A
N
-
P
K
G
D
C
--------------
S
E
T
F
V
Y
I
T
N
----
F
L
--
R
G
A
L
F
I
--
Y
-
D
---
H
--
K
---
K
-
Q
D
S
W
N
V
-----
T
H
P
T
F
K
---------------------------
A
E
R
P
T
K
-
F
D
--
Y
-
G
G
-
K
E
Y
E
-
F
K
A
G
I
F
-
G
-------------
I
T
L
G
D
R
D
S
E
G
----------------
N
R
P
A
Y
Y
L
A
G
------
S
-------------------
A
I
K
V
Y
S
V
N
---
T
K
E
-----
L
K
----
Q
K
-
G
G
-------
K
-------
L
N
--
P
E
L
L
G
N
R
-------
G
K
Y
N
D
A
I
A
--
L
A
Y
D
-----------------------
P
K
T
K
----
V
I
F
F
A
E
A
N
--
T
K
Q
V
S
C
W
N
T
Q
K
-
M
P
L
----
R
M
K
N
T
D
V
---------------
V
Y
T
S
S
R
-
F
------
V
F
G
T
D
I
S
V
D
-
S
-
K
G
G
L
W
F
----------
M
S
N
G
F
P
P
I
R
K
S
E
K
F
-----
K
Y
D
F
P
R
Y
R
L
M
R
--
I
---
M
D
-----
T
Q
E
A
I
A
G
T
A
C
D
M
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
SP3
52.47
9%
-8
- C6 -
-
1KOB
1
?
A:
[23-374]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
---
Q
P
V
E
-
V
K
--------------
Q
G
-
S
V
Y
D
Y
---
Y
D
I
--
L
-
E
E
L
G
S
G
A
F
G
V
-------
V
H
R
C
V
E
K
A
T
-
G
R
V
F
V
A
--
K
F
I
N
-------------------------------------------------
T
----
P
Y
P
L
D
K
Y
----
T
V
K
N
E
I
S
I
M
N
Q
L
------
H
------
H
P
K
---------
L
I
N
L
H
D
A
F
E
D
K
Y
E
--------------
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
--
R
I
A
A
E
D
--
Y
-
K
---
M
--
S
E
A
E
V
-
I
N
Y
M
R
Q
-----
A
C
E
G
L
K
---
H
M
H
------
E
H
S
I
V
H
L
------
D
I
K
P
E
N
I
M
-
C
E
TK
K
-
A
S
-
S
V
K
I
-
I
D
F
G
L
A
-
T
K
L
N
P
D
E
I
--------
V
K
V
T
T
A
T
A
----------------
E
F
A
A
P
E
I
V
D
------
R
E
-----
P
V
G
--
F
---
Y
T
--
D
M
W
A
I
G
V
L
---
G
Y
V
-----
L
L
----
S
G
-
L
S
-------
P
-------
F
A
--
G
E
D
-------------
D
L
E
T
L
Q
--
N
V
K
R
C
D
W
E
F
D
E
----------
D
A
F
----------------------
S
S
V
S
--
P
E
A
K
-
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
---------------
L
T
V
H
D
A
-
L
E
HPWLK
G
D
H
S
N
L
T
S
R
-
I
P
S
S
R
Y
N
K
----------
I
R
Q
K
I
K
E
-
K
Y
A
D
W
P
-----
A
P
Q
P
A
I
G
R
I
A
N
FS
S
---
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
52.40
15%
-10
- C6 -
-
2Q0N
7
A:
[8-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
V
S
H
E
-
Q
F
------
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
---
L
D
N
F
---
I
K
I
G
E
G
S
T
G
I
-------
V
C
I
A
T
V
R
S
S
-
G
K
L
V
A
V
--
K
K
M
D
L
R
K
Q
-
Q
R
R
-------------------
E
-------------------------------------
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
-----------
E
N
---------
V
V
E
M
Y
N
S
Y
L
V
G
D
E
--------------
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
--
I
V
T
H
T
R
M
-
N
-
E
---
E
--
Q
--
I
A
-
A
V
C
L
A
V
-----
L
Q
A
-
L
S
---
V
L
H
------
A
Q
G
V
I
H
R
------
D
I
K
S
D
S
I
L
-
L
T
--
H
-
D
G
-
R
V
K
L
-
S
D
F
G
F
C
-
A
Q
V
S
K
E
V
P
R
-------
R
K
S
L
V
G
T
P
----------------
Y
W
M
A
P
E
L
I
S
------
R
L
-----
P
Y
G
--
P
---
E
V
--
D
I
W
S
L
G
I
M
---
V
I
E
-----
M
V
----
D
G
-
E
----------------
P
P
--
Y
F
N
E
P
P
L
-------
K
A
M
K
M
I
R
-----
D
----
N
L
P
P
--------------------------------
R
L
K
N
L
H
K
V
S
P
S
L
K
-
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
---------------
A
T
A
A
E
L
-
L
K-----
H
P
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
51.32
15%
-53
- C6 -
-
5H0B
1
HCK_HUMAN
A:
[120-380]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
---------------------
G
F
Y
I
S
P
R
S
T
--
F
----
S
T
L
Q
----
E
-
L
-
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
---
C
M
S
S
-
K
P
------
Q
K
P
W
E
K
D
A
W
E
-
I
P
R
E
S
---
L
K
L
E
---
K
K
L
G
A
G
Q
F
G
E
-------
V
W
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
--
K
T
M
K
P
G
S
M
-
S
V
-----------------------------------------------------
E
----
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
-----------
D
K
---------
L
V
K
L
H
A
V
-
V
T
K
E
P
--------------
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
--
F
L
K
S
D
E
--
G
S
K
QP
L
P
--
K
--
L
I
-
D
F
S
A
Q
I
-----
A
E
G
-
M
A
---
F
I
E
------
Q
R
N
Y
I
H
R
------
D
L
R
A
A
N
I
L
-
V
S
--
A
-
S
L
-
V
C
K
I
-
A
D
F
G
L
A
-
R
V
I
E
D
N
E
Y
T
------
A
R
E
G
A
K
F
P
I
----------------
K
W
T
A
P
E
A
I
N
------
F
G
-----
S
F
T
--
I
---
K
S
--
D
V
W
S
F
G
I
L
---
L
M
E
-----
I
V
----
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
49.56
14%
-9
- C6 -
-
2Y7J
1
PHKG2_HUMAN
A:
[82-362]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
-------
V
R
R
C
V
H
R
A
T
-
G
H
E
F
A
V
--
K
I
M
E
V
T
A
E
-
R
L
S
P
E
-----
Q
L
E
E
V
------
R
E
-------------------------------------
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
-----------
P
H
---------
I
I
T
L
I
D
S
Y
E
S
S
S
F
--------------
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
--
Y
L
T
E
K
V
AL
S
-
E
---
K
--
E
--
T
R
-
S
I
M
R
S
L
-----
L
E
A
-
V
S
---
F
L
H
------
A
N
N
I
V
H
R
------
D
L
K
P
E
N
I
L
-
L
D
--
D
-
N
M
-
Q
I
R
L
-
S
D
F
G
F
S
-
C
H
L
E
P
G
E
K
L
--------
R
E
L
C
G
T
P
----------------
G
Y
L
A
P
E
I
L
K
C
S
M
D
ET
H
P
-----
G
Y
G
--
K
---
E
V
--
D
L
W
A
C
G
V
I
---
L
F
T
-----
L
L
----
A
G
-
S
----------------
P
P
--
F
W
H
R
R
Q
I
-------
L
M
L
R
M
I
M
E
----
G
Q
Y
Q
F
S
S
------------------------------------
P
E
W
D
D
R
S
S
T
V
K
-
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
---------------
L
T
A
E
Q
A
-
L
Q
-----
H
P
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
HHSearch
49.15
16%
-21
- C6 -
-
3COM
-
STK4_HUMAN
B:
[16-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
D
E
D
S
L
T
K
-
Q
P
E
E
V
---
F
D
V
L
---
E
K
L
G
----
G
S
-------
V
Y
K
A
I
H
K
-
E
T
G
Q
I
V
A
I
--
K
Q
V
P
V
E
S
D
-
L
---------------------
Q
-------------------------------------
E
I
I
K
E
I
S
I
M
Q
Q
C
-
D
S
-----------
P
H
---------
V
V
K
Y
Y
G
S
Y
F
K
N
T
D
--------------
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
--
I
I
R
L
R
N
--
K
-
T
L
T
E
D
--
E
--
I
A
-
T
I
L
Q
S
T
-----
L
K
G
-
L
E
---
Y
L
H
------
F
M
R
K
I
H
R
------
D
I
K
A
G
N
I
L
-
L
N
--
T
-
E
G
-
H
A
K
L
-
A
D
F
G
V
A
-
G
Q
L
T
D
T
M
A
K
-------
R
N
T
V
I
G
T
P
----------------
F
W
M
A
P
E
V
I
Q
------
E
I
-----
G
Y
N
--
C
---
V
A
--
D
I
W
S
L
G
I
T
---
A
I
E
-----
M
A
----
E
G
-
K
----------------
P
P
--
Y
A
D
I
H
P
M
-------
R
A
I
F
M
I
-------------
P
----------------------------
T
N
P
P
P
T
F
R
K
P
E
L
W
S
D
N
F
T
-
D
F
V
K
Q
C
L
V
K
S
P
E
Q
R
---------------
A
T
A
T
Q
L
-
L
Q-----
H
P
F
V
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
49.09
15%
-6
- C7 -
-
5T8V
1
?
A:
[4-1456]
GESLD
L
R
Q
R
A
N
V
A
L
H
E
L
K
A
Y
L
Q
A
A
F
Q
A
V
D
R
A
I
A
Q
KSSNEM
A
I
F
L
S
ET
E
A
T
L
A
A
P
T
Q
T
K
L
Q
S
A
L
K
K
T
I
E
L
NCFMTVP
L
D
D
L
I
Y
L
L
R
L
C
D
S
A
L
R
Q
T
E
SLDFSVQTSWG
A
Q
D
V
E
Q
W
L
E
L
L
P
N
L
E
A
A
I
R
A
A
R
T
S
M
R
I
M
C
GGREEKQLYS
E
N
A
I
E
Q
A
L
S
L
C
K
R
L
I
D
G
I
I
M
P
L
A
E
LRNTSDT
E
E
L
F
K
A
L
S
S
C
K
R
R
I
L
P
L
M
T
D
A
Q
K
L
L
S
M
M
S
E
L
I
A
K
V
DTS
E
T
V
T
N
A
L
E
F
A
A
S
Q
L
L
F
IETANAERDSVIE
T
Q
K
F
D
G
F
R
L
V
A
M
D
M
I
C
Q
I
F
L
L
N
PSQ
R
Q
G
I
I
D
E
I
L
T
S
L
E
K
LPLGKRARTFKLADG
S
S
I
Q
P
V
S
A
L
I
M
R
L
V
Q
TSAGIIQS
E
A
Q
G
A
S
Q
H
S
T
A
I
R
D
L
D
T
I
S
T
P
L
L
E
T
A
R
N
N
A
S
Y
V
I
K
F
I
V
N
R
A
L
NSPY
R
N
L
L
D
L
F
V
E
D
F
I
T
C
L
DNPDWPA
A
E
L
L
L
R
L
L
M
L
M
M
V
G
L
V
E
N
DKSS
I
M
A
K
N
M
A
L
E
L
L
G
T
M
C
A
A
I
S
K
L
R
G
H
V
R
K
M
A
S
ALEAD
E
L
S
L
F
L
S
D
L
A
A
S
A
L
E
LKSR
P
E
H
M
V
AWTG
P
Y
R
A
T
L
E
Y
L
Q
S
R
SNED
A
Q
L
S
S
A
M
T
F
I
I
S
E
W
G
S
K
I
-----
C
T
C
Y
D
G
YQD
D
V
L
E
R
D
Q
E
L
G
R
L
A
--
Y
R
L
R
E
M
I
--
L
D
R
K
W
L
S
T
E
Y
T
Y
K
D
----
V
S
---------------------
P
L
Q
A
K
L
S
Y
S
--
I
----
I
L
L
R
----
S
-
Q
-
F
C
E
A
F
G
A
I
L
N
I
L
L
N
S
M
A
S
----
D
Q
P
-
T
V
------
R
S
K
S
L
K
S
I
N
Q
-
V
M
E
A
D
---
P
T
I
L
D
G
-
D
S
V
V
V
Q
L
I
L
R
-------
S
S
S
D
S
S
T
-
Q
-
V
R
D
S
A
L
--
G
L
I
S
K
C
I
S
-
L
R
---------------
P
A
L
E
E
K
M
T
--
E
T
V
V
N
R
F
S
-
D
A
G
P
G
V
R
K
R
----
A
M
K
L
A
K
D
----
I
Y
L
R
N
S
N
R
V
L
R
S
-
A
I
A
N
G
L
------
L
H
R
---------
V
Q
D
P
E
E
S
V
R
D
L
A
R
--------------
Q
V
I
E
E
I
W
F
A
P
S
L
S
E
H
--
V
I
L
M
V
Q
--
T
-
V
---
K
R
G
N
--
V
A
-
N
V
L
D
K
V
-----
L
Q
A
L
L
S
PSS
K
T
S
------
Q
A
S
M
E
V
C
------
R
K
L
V
G
S
M
F
D
L
I
--
D
-
N
N
-
D
A
S
A
-
P
S
-----
G
R
D
V
L
Q
V
L
M
I
F
-
A
K
A
E
A
S
L
F
T
F
E
Q
----------------
L
R
L
L
R
P
Y
I
A
------
S
I
-----
G
T
S
-------------
E
D
L
T
V
---
S
R
A
-----
V
V
----
V
I
-
Y
R
---------------
R
V
--
L
P
Q
L
S
S
A
-------
H
A
Q
F
L
T
D
V
--
R
K
E
L
L
P
V
V
A
K
V
----------
P
R
A
L
-
L
D
D
V
M
----
A
C
L
W
I
I
S
T
L
L
G
T
Y
E
P
L
A
R
L
V
I
-
S
S
L
K
G
I
Q
K
T
R
A
S
A
Q
---------------
V
Q
P
L
D
Q
L
K
------
I
R
Q
F
D
R
Y
S
L
-
I
-
V
G
M
A
G
K
HCNLDSH
H
E
M
F
K
E
H
F
P
K
-
F
S
G
A
S
V
-----
S
K
L
M
V
D
I
V
V
P
F
--
A
---
A
P
S
W
P
L
D
V
R
K
P
A
L
D
C
V
G
L
V
C
Q
S
S
P
R
N
Y
V
AANV
Y
T
A
F
Q
Q
V
F
D
D
QI
P
I
L
E
T
M
V
L
R
S
L
K
E
F
L
F
S
E
E
K
R
S
ETNY
D
D
V
A
S
A
T
T
H
R
F
L
K
D
I
T
R
I
A
T
STQD
D
H
A
F
L
A
V
E
V
L
A
S
I
N
R
Q
GLVHPKET
G
V
T
F
I
T
L
A
T
STH
P
R
I
S
E
L
A
F
L
E
H
K
A
L
H
T
K
H
E
T
V
I
E
R
E
Y
A
K
A
I
Q
S
I
F
A
Y
Q
R
DIVKDPRGATTNPFTPKL
H
L
F
M
E
V
L
K
ISKAK
N
R
V
K
F
L
E
K
L
V
S
Q
I
DFDIAKLELP
P
H
V
Q
Y
S
R
F
I
I
E
N
L
A
FFEYVT
V
G
E
I
H
S
L
V
A
A
M
E
R
L
V
A
S
T
G
A
S
V
A
Q
V
I
E
S
EVR
L
R
Q
L
T
A
A
S
M
I
L
L
A
I
W
E
V
R
T
Y
L
R
R
L
YSLA
R
P
P
V
K
V
Q
GVTG
D
K
V
W
E
E
I
N
N
I
M
G
A
LSGG
R
E
R
M
V
R
A
C
K
D
L
V
E
L
M
SID
57
HHSearch
49.05
16%
-58
- C6 -
-
1AD5
1
HCK_HUMAN
A:
[116-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
K
H
Y
K
I
R
T
L
D
N
G
---------------------
G
F
Y
I
S
P
R
S
T
--
F
----
S
T
L
Q
----
E
-
L
-
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
---
C
M
S
S
-
K
P
------
Q
K
P
W
E
K
D
A
W
E
-
I
P
R
E
S
---
L
K
L
E
---
K
K
L
G
A
G
Q
F
G
E
-------
V
W
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
--
K
T
M
K
P
G
S
M
-
S
V
--------------------
E
-------------------------------------
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
-----------
D
K
---------
L
V
K
L
H
A
V
V
-
T
K
E
P
--------------
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
--
F
L
K
S
D
E
--
G
S
K
QP
L
P
--
K
--
L
I
-
D
F
S
A
Q
I
-----
A
E
G
-
M
A
---
F
I
E
------
Q
R
N
Y
I
H
R
------
D
L
R
A
A
N
I
L
-
V
S
--
A
-
S
L
-
V
C
K
I
-
A
D
F
G
L
A
-
R
V
G
A
K
----------------
F
P
I
----------------
K
W
T
A
P
E
A
I
N
------
F
G
-----
S
F
T
--
I
---
K
S
--
D
V
W
S
F
G
I
L
---
L
M
E
-----
I
V
----
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
48.06
16%
-26
* C8 *
-
4M59
-
?
A:
[6-714]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PD
A
Q
V
L
V
L
A
I
S
S
HPLPT
L
A
A
F
L
A
S
R
R
D
E
L
L
R
AD
I
T
S
L
L
K
A
L
E
L
S
GH
W
E
W
A
L
A
L
L
R
W
A
G
K
E
GAAD
A
S
A
L
E
M
V
V
R
A
L
G
R
E
GQ
H
D
A
V
C
A
L
L
D
ETPLPPG
S
R
L
D
V
R
A
Y
T
T
V
L
H
A
L
S
R
A
G
R
Y
E
-----
R
A
L
E
L
F
---
A
E
L
R
R
Q
G
V
A
P
T
L
V
T
Y
N
V
V
L
D
V
Y
G
-
R
M
G
R
S
W
P
R
I
V
A
L
L
D
E
M
R
A
A
G
V
E
P
D
G
F
T
A
S
T
V
I
A
A
C
S
R
D
GL
V
D
E
A
V
A
F
F
E
D
--
L
----
K
A
R
G
----
H
-
A
-
P
S
V
V
T
Y
N
A
L
L
Q
V
F
G
K
A
G
N
---
Y
T
E
A
L
R
V
------
L
G
E
M
E
Q
N
G
C
Q
-
P
D
A
V
T
---
Y
N
E
L
A
G
-
T
E
E
A
A
R
C
L
D
T
M
A
SPN
A
F
T
Y
N
T
V
M
T
-
A
-
Y
G
N
V
G
K
--
V
D
E
A
L
A
L
F
-
D
Q
M
K
K
T
G
F
V
P
N
V
N
T
Y
N
L
V
L
G
M
L
G
K
K
--
S
R
F
T
V
M
L
E
-
M
L
G
E
M
S
R
S
G
C
T
P
N
R
V
T
W
N
T
M
L
AVS
G
K
R
G
M
E
D
Y
V
T
R
V
-
L
E
G
M
R
S
S
G
V
E
L
S
R
D
T
---------
Y
N
T
L
I
A
A
Y
G
R
C
G
S
--------------
R
T
N
A
F
K
M
Y
N
E
M
T
S
A
G
--
F
T
P
C
I
T
--
T
-
Y
---
N
--
A
--
L
L
-
N
V
L
S
R
Q
-----
G
D
W
S
T
A
---
Q
S
I
------
V
S
K
M
R
T
K
G
F
K
P
N
E
Q
S
Y
S
L
L
L
Q
-
C
Y
--
A
-
K
G
-
G
N
V
A
-
G
I
A
A
I
E
-
N
E
V
Y
G
S
G
A
V
F
P
S
W
V
I
L
R
T
L
V
I
A
N
F
K
C
--------------
R
R
L
D
G
M
E
T
A
------
F
Q
-----
E
V
K
--
A
RG
Y
N
P
--
D
L
V
I
F
N
S
M
---
L
S
I
-----
Y
A
K
N
GM
Y
S
-
K
A
-------
T
-------
E
V
--
F
D
S
I
K
R
S
-------
G
L
S
P
D
L
I
T
--
Y
N
S
L
M
D
M
Y
A
K
C
SE
S
W
E
A
E
K
I
L
N
Q
L
K
-
C
S
Q
T
M
KPD
V
V
S
Y
N
T
V
I
N
G
F
C
K
Q
-
G
L
V
K
E
A
Q
-
R
V
L
S
E
M
V
A
D
G
M
A
P
C
---------------
A
V
T
Y
H
T
-
L
------
V
G
G
Y
S
S
L
E
M
-
F
-
S
E
A
R
E
V
----------
I
G
Y
M
V
Q
H
-
G
L
K
--------
P
M
E
L
T
Y
R
R
V
V
E
--
S
---
Y
C
R
A
F
E
E
A
R
G
F
L
S
E
V
K
A
L
E
A
Y
I
E
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
HHSearch
43.89
15%
-32
* C6 *
-
3CBL
3
A:
[120-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
I
G
R
G
N
F
G
E
-------
V
F
S
G
R
L
R
-
A
D
N
T
L
V
A
V
--
K
S
C
R
E
T
L
P
-
P
D
L
K
---------------------------------------------------
A
----
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
-----------
P
N
---------
I
V
R
L
I
G
V
C
T
Q
K
Q
P
--------------
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
--
F
L
R
T
E
G
--
A
-
R
LR
V
K
--
T
--
L
L
-
Q
M
V
G
D
A
-----
A
A
G
-
M
E
---
Y
L
E
------
S
K
C
C
I
H
R
------
D
L
A
A
R
N
C
L
-
V
T
--
E
-
K
N
-
V
L
K
I
-
S
D
F
G
M
S
-
R
E
E
A
D
G
V
Y
A
A
-----
S
G
G
L
R
Q
V
P
V
----------------
K
W
T
A
P
E
A
L
N
------
Y
G
-----
R
Y
S
--
S
---
E
S
--
D
V
W
S
F
G
I
L
---
L
W
E
-----
T
F
----
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
43.27
15%
11
- C6 -
-
1TQM
1
RIO2_ARCFU
A:
[1-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
--
I
----
A
E
L
Y
----
G
-
K
-
M
G
K
H
S
W
R
I
M
D
A
I
F
K
N
L
W
D
YEY
V
P
L
Q
-
L
I
------
S
S
H
A
R
I
G
E
E
K
-
A
R
N
I
L
---
K
Y
L
S
D
L
-
R
V
V
Q
N
R
Q
K
D
Y
-------
E
G
S
T
F
T
F
-
I
-
G
L
S
L
Y
S
L
H
R
L
V
R
S
G
K
V
-
D
A
I
G
K
-----
L
M
G
E
G
K
E
S
A
V
F
N
C
Y
S
--
E
------
K
-
F
G
E
C
V
V
K
F
H
----
K
V
K
V
K
E
H
----
F
S
V
L
A
I
R
S
A
R
N
E
-
F
R
A
L
Q
K
------
L
Q
G
---------
L
A
V
P
K
V
Y
A
W
E
G
N
----------------
A
V
L
M
E
L
I
D
A
K
E
L
Y
R
--
V
R
------------
V
--
E
--
N
P
-
D
E
V
L
D
M
-----
I
L
E
E
V
A
---
K
F
Y
------
H
R
G
I
V
H
G
------
D
L
S
Q
Y
N
V
L
-
V
S
--
E
-
E
G
--
I
W
I
-
I
D
F
P
Q
S
-
V
E
V
G
E
E
G
W
R
E
I
-
L
E
R
D
V
R
N
I
I
T
Y
F
----------------
S
R
T
Y
R
T
E
K
D
------
I
N
-----
S
A
I
--
D
---
R
I
--
L
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
HHSearch
39.24
16%
-37
- C6 -
-
4G3F
1
A:
[64-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
V
G
R
G
S
F
G
E
-------
V
H
R
M
K
D
K
-
Q
T
G
F
Q
C
A
V
--
K
K
V
R
L
E
V
F
--------------------------------------------------------------
R
V
E
E
L
V
A
C
A
G
L
-
S
S
-----------
P
R
---------
I
V
P
L
Y
G
A
V
R
E
G
P
W
--------------
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
--
L
I
K
Q
M
G
CL
P
-
E
---
D
--
R
--
A
L
-
Y
Y
L
G
Q
A
-----
L
E
G
-
L
E
---
Y
L
H
------
T
R
R
I
L
H
G
------
D
V
K
A
D
N
V
L
-
L
S
--
S
-
D
G
S
R
A
A
L
-
C
D
F
G
H
A
-
L
C
L
--------------
D
Y
I
P
G
T
E
----------------
T
H
M
A
P
E
V
V
M
------
G
K
-----
P
C
D
--
A
---
K
V
--
D
I
W
S
S
C
C
M
---
M
L
H
-----
M
L
----
N
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------