@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : D5HFE1_9FIRM: (2019-01-27 )
MRRTTIDEAIARVDDWKGKEISYKPVSGGITNPNFKVDVEGEHFFLKIPGAGTDYINREVCHEANMIADESKAGPRVYYYFEDTGVEIFQWLDGYRQVTFGDVYDKDIFQSIFERIRDFHHLETKPLNLKQSIFEQAWDMNARAKKGGYISPFNDKMEYLLSAIEKALAGSEELCPCHNDFWTNNLMYNEETNDLKIIDYEYASMNDPYVDLGLISAVNYFTEDMDVEMMKIYGGGKVDERAFARMKLNKIACDIKWAYWALYQAASSNVEFDYMNWYGQKMARLQHFWLDSRLDYWLDVAREKSTRIS
Atome Classification :
(21 SA)
-------------------------------------.........10..-.----....---.20-.........30...-.....---------40--------.----------........50..-..--....60.....-..--.--70.....-----...80......--.-------.90....--.-...-------------100..-..-----...110-.........120----------..----..----...-------------130----------.....---------------....140--....-------------...---------150-----.--.-------------.----..----------.--------...--160-.....------------..--.-.-170.-.-...--------...180......-----.190-----..-......200.......210.------------------.---------------...------------------..------------------220-------.------------------.------------------...-------------------------------------....230...-------------.----------..--------------.----------240.......250.......260.......--270.......280....-...290.......300.......---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------------MRR
T
T
I
D
E
A
I
A
R
V-D----DWKG---K
E
--
I
S
Y
KPVSGGITNP
N
-
F
K
V
D
V---------E---------G----------
E
H
F
F
L
K
IPGAG
T
-
D
Y
--
I
N
R
E
V
C
H
E
A
N
M-IA--D--ESKAG
P
R
-----
V
Y
Y
Y
FEDTG
V
E
--
I
-------
F
Q
W
L
D
GY--R-QVT-------------FGDVY-
D
K
-----
D
I
F
Q
---
S
I
F
E
R
I
R
D
F
HHL----------ET----KP----
L
N
L
-------------
K
------------
Q
S
I
F
E
---------------
Q
A
WDMNA--RAKK-------------GGY---------I-------S--P-------------
F
----
N
D
----------
K
--------
M
E
Y
--
L
---
L
S
A
I
E
------------
K
A
--L-A-G-SE-E-LCP--------CHNDFWTNN
L
M
Y-----NE-E-----TN-
D
L
K
I
I
D
Y
E
YASMNDP
Y
V
D
L
G
------------------
L
---------------
I
S
A
------------------
V
N
------------------
Y
---------
F
------------------T------------------EDM-------------------------------------D
V
E
M
M
K
I
YGG-------------G----------KV--------------
D
----------
E
R
A
F
A
R
M
K
L
N
K
I
A
C
D
I
K
W
A
Y
W
A
L
Y
Q
AASSN--
V
E
F
D
Y
M
N
W
Y
G
Q
K
M
A
R
L
Q
-
H
F
W
L
D
S
R
L
D
Y
W
L
D
V
A
R
EKSTRIS---
177
HHSearch
75.70
25%
1
- C3 -
-
3DXQ
-
?
B:
[2-300]
--------------------------------------
M
T
D
E
A
R
A
K
L
A
A
I
-
P
----
M
L
A
G
---
Y
---
T
G
P
L
E
R
L
G
G
L
T
N
L
V
-
F
R
A
--------------------------------
G
D
L
C
L
R
I
P
----------
N
R
A
N
E
A
V
A
A
R
-
E
A
--
A
--
K
A
G
V
S
P
E
-----
V
L
H
V
D
P
A
T
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V
M
--
V
-------
T
R
Y
I
A
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---
A
Q
T
M
S
-------------
P
E
K
F
K
T
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P
-----
G
S
P
A
---
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A
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L
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----------
G
A
-----
V
----
F
P
F
-------------
R
------------
F
E
L
F
A
---------------
M
I
D
D
Y
L
K
--
V
L
S
T
-------------
K
N
------------------
V
--
T
-------------
L
----
P
A
----------
G
--------
Y
H
D
--
V
---
V
R
E
A
G
G
V
R
---------
S
A
--
L
A
A
-
H
-
P
L
-
P
-
L
A
A
--------
C
H
C
D
P
L
C
E
N
F
L
D
-----
T
G
--------
E
-
R
M
W
I
V
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
------------------
D
---------------
L
S
V
------------------
E
G
------------------
K
---------
F
------------------
N
------------------
A
N
Q
-------------------------------------
D
E
E
L
M
R
A
Y
F
G
-------------
G
----------
E
A
--------------
R
----------
P
A
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R
G
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
I
Q
L
A
N
D
N
--
P
V
D
D
F
R
A
Y
A
D
G
R
F
A
R
C
K
-
A
L
M
E
T
P
E
F
S
R
H
L
A
A
V
R
M
G
--------
178
HHSearch
71.72
25%
-1
- C- -
-
3DXQ
-
?
A:
[2-300]
--------------------------------------
M
T
D
E
A
R
A
K
L
A
A
I
-
P
----
M
L
A
G
---
Y
---
T
G
P
L
E
R
L
G
G
L
T
N
L
V
-
F
R
A
--------------------------------
G
D
L
C
L
R
I
P
G
K
----
Y
--
I
N
R
A
N
E
A
V
A
A
R
-
E
A
--
A
--
K
A
G
V
S
P
E
-----
V
L
H
V
D
P
A
T
G
V
M
--
V
-------
T
R
Y
I
A
G
---
A
Q
T
M
S
-------------
P
E
K
F
K
T
R
P
-----
G
S
P
A
---
R
A
G
E
A
F
R
K
L
H
G
S
----------
G
A
-----
V
----
F
P
F
-------------
R
------------
F
E
L
F
A
---------------
M
I
D
D
Y
L
K
--
V
L
S
---------------
N
------------------
V
--
T
-------------
L
----
P
A
----------
G
--------
Y
H
D
--
V
---
V
R
E
A
G
G
V
R
---------
S
A
--
L
A
A
-
H
-
P
L
-
P
-
L
A
A
--------
C
H
C
D
P
L
C
E
N
F
L
D
-----
T
G
--------
E
-
R
M
W
I
V
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
------------------
D
---------------
L
S
V
------------------
E
G
------------------
K
---------
F
------------------
N
------------------
A
N
Q
-------------------------------------
D
E
E
L
M
R
A
Y
F
G
-------------
G
----------
E
A
--------------
R
----------
P
A
E
R
G
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
I
Q
L
A
N
D
N
--
P
V
D
D
F
R
A
Y
A
D
G
R
F
A
R
C
K
-
A
L
M
E
T
P
E
F
S
R
H
L
A
A
V
R
M
G
--------
186
HHSearch
69.37
20%
6
- C3 -
-
5FUT
9
CHKA_HUMAN
A:
[31-375]
----------------------------------------------------------------
E
--
F
H
I
S
V
I
R
G
G
L
S
N
M
L
-
F
Q
C
S
L
---------
P
---------
D
TTATLGDEP-
R
K
V
L
L
R
L
Y
G
------G
A
E
A
M
V
L
E
S
V
M
F
A
-
I
L
--
A
--
E
R
S
L
G
P
K
-----
L
Y
G
I
F
P
Q
--
G
R
--
L
-------
E
Q
F
I
P
S
---
R
-
R
L
D
-------------
T
E
E
L
S
-
L
P
-----
D
I
S
A
---
E
I
A
E
K
M
A
T
F
H
G
M
----------
K
M
----
P
F
----
N
K
E
-------------
P
------------
K
W
L
F
G
---------------
T
M
E
K
Y
L
K
--
E
V
L
R
-------------
I
K
F
TE
E
S
R
----
I
-------
K
--
K
-------------
L
H
K
L
L
S
Y
----------
N
--------
L
P
L
--
E
---
L
E
N
L
R
------------
S
L
--
L
E
S
-
T
-
P
S
-
P
-
V
V
F
--------
C
H
N
D
C
Q
E
G
N
I
L
L
-----
L
E
-
G
RENSE
K
Q
-
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
------------------
N
---------------
H
F
C
------------------
E
W
------------------
M
---------
Y
------------------
D
YSYEKYPF
F
R
A
N
IRKYPT
K
K
Q
-------------------------------------
Q
L
H
F
I
S
S
Y
L
P
-------------
A
----------
F
Q
NDFENLS
T
E
E
K
S
I
I
K
----------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
--
I
E
F
G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
F
-
H
Q
K
R
K
---------------------
185
HHSearch
69.07
20%
-0
- C3 -
-
5FTG
10
CHKA_HUMAN
A:
[31-375]
----------------------------------------------------------------
E
--
F
H
I
S
V
I
R
G
G
L
S
N
M
L
-
F
Q
C
S
L
---------
P
---------
D
TTATLGDEP-
R
K
V
L
L
R
L
Y
G
--------
E
A
M
V
L
E
S
V
M
F
A
-
I
L
--
A
--
E
R
S
L
G
P
K
-----
L
Y
G
I
F
P
Q
--
G
R
--
L
-------
E
Q
F
I
P
S
---
R
-
R
L
D
-------------
T
E
E
L
S
-
L
P
-----
D
I
S
A
---
E
I
A
E
K
M
A
T
F
H
G
M
----------
K
M
----
P
F
----
N
K
E
-------------
P
------------
K
W
L
F
G
---------------
T
M
E
K
Y
L
K
--
E
V
L
R
-------------
I
K
F
TE
E
S
R
----
I
-------
K
--
K
-------------
L
H
K
L
L
S
Y
----------
N
--------
L
P
L
--
E
---
L
E
N
L
R
------------
S
L
--
L
E
S
-
T
-
P
S
-
P
-
V
V
F
--------
C
H
N
D
C
Q
E
G
N
I
L
L
-----
L
E
-
G
RENSE
K
Q
-
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
------------------
N
---------------
H
F
C
------------------
E
W
------------------
M
---------
Y
------------------
D
YSYEKYPF
F
R
A
N
IRKYPT
K
K
Q
-------------------------------------
Q
L
H
F
I
S
S
Y
L
P
-------------
A
----------
F
Q
NDFENLS
T
E
E
K
S
I
I
K
----------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
--
I
E
F
G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
F
-
H
Q
K
R
K
---------------------
187
HHSearch
66.32
18%
18
- C3 -
-
3C5I
3
?
D:
[14-355]
---------------------------------------
P
L
Y
I
K
K
I
C
L
E
K
V
P
----
E
W
N
H
FTE
D
N
--
L
R
V
K
Q
I
L
--
L
T
N
Q
L
-
F
E
V
G
L
---------
K
---------
E
E
T
A
N
N
Y
NSIR
T
R
V
L
F
R
I
Y
G
K
H
V
D
E
L
--
Y
N
T
I
S
E
F
E
V
Y
K
-
T
M
--
S
--
K
Y
K
I
A
P
Q
-----
L
L
N
T
F
--
N
G
G
R
--
I
-------
E
E
W
L
Y
G
---
D
-
P
L
R
-------------
I
D
D
L
K
-
N
P
-----
T
I
L
I
---
G
I
A
N
V
L
G
K
F
H
T
L
----------
S
R
-----
K
----
R
H
L
-------------
P
EHWDRT------
P
C
I
F
K
---------------
M
M
E
K
W
K
N
--
Q
L
F
K
-------------
Y
K
N
---------
I
EKYNCD
I
H
--
K
-------------
Y
----
I
K
----------
E
--------
S
D
K
--
F
---
I
K
F
M
K
------------
V
Y
S
K
S
D
N
-
L
-
A
N
-
T
-
I
V
F
--------
C
H
N
D
L
Q
E
N
N
I
I
N
-----
T
N
--------
K
-
C
L
R
L
I
D
F
E
Y
S
G
F
N
F
L
A
T
D
I
A
------------------
N
---------------
F
F
I
------------------
E
T
------------------
S
---------
I
DYSVSSYPF
F
E
I
D
KKKYI
S
------------------
Y
E
N
-------------------------------------
R
K
L
F
I
T
A
Y
L
S
-------------
N
----------
Y
L
DKVVP---------
T
P
K
L
I
------
D
E
I
L
E
A
V
E
V
Q
A
L
G
A
H
L
L
W
G
F
W
S
I
I
R
G
Y
Q
T
K
SY
N
E
F
D
F
F
L
Y
A
E
Q
R
L
K
M
Y
D
-
D
Q
------------------------
4
PsiBlast_PDB
65.41
21%
12
- C2 -
-
2CKQ
1
CHKA_HUMAN
A:
[54-373]
---------------------------------------------------------
W
R
G
LRE
D
E
--
F
H
I
S
V
I
R
G
G
L
S
N
M
L
-
F
Q
C
S
L
PDT
T
A
T
L
G
D
E
---------
P
----------
R
K
V
L
L
R
L
Y
G
-----------
A
M
V
L
E
S
V
M
-
F
A
I
L
A
--
E
R
S
L
G
P
K
-----
L
Y
G
I
F
P
Q
G
R
L
E
--
Q
-------
F
---
I
P
S
--
R
-
R
L
D
-------------
T
E
E
L
S
-
L
P
-----
D
I
S
A
---
E
I
A
E
K
M
A
T
F
H
G
M
----------
K
M
-----
P
----
F
N
K
-------------
E
PKW
L
F
G
T
M
E
K
Y
L
K
E
V
L
R
---------------
I
K
F
T
E
E
S
--
R
I
K
K
-------------
L
H
K
---------
L
-------
L
--
S
-------------
Y
----
N
L
----------
P
--------
L
E
L
E
N
L
---
R
S
L
L
E
------------------
S
-
T
-
P
S
-
P
-
V
V
F
--------
C
H
N
D
C
Q
E
G
N
I
L
L
LEGRE
N
S
-------
K
Q
-
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
--------------------------------------------------------
N
------------------
H
---------
F
------------------
C
------------------
E
W
M
Y
DYSYEKYPF
F
R
A
N
IRKYPT
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
L
S
T
E
E
K
-------------
S
----------
I
I
--------------
K
----------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
--
I
E
F
G
Y
M
D
Y
------------------------------------
179
HHSearch
63.18
20%
26
* C3 *
-
4R7B
-
?
A:
[24-304]
-----------------------------------------
I
I
K
E
K
I
S
S
L
-
L
----
S
Q
E
E
---
E
V
--
L
S
V
E
Q
L
-
G
G
M
T
N
Q
N
-
Y
L
A
K
T
---------
T
---------
N
----------
K
Q
Y
I
V
K
F
F
G
K
G
T
E
K
L
--
I
N
R
Q
D
E
K
Y
N
L
E
-
L
L
--
K
--
D
L
G
L
D
V
K
-----
N
Y
L
F
D
I
E
A
G
I
K
--
V
-------
N
E
Y
I
E
S
---
A
I
T
L
D
-------------
S
T
--
S
-
I
K
-----
T
K
F
D
---
K
I
A
P
I
L
Q
T
I
H
T
S
----------
A
K
-----
E
----
L
R
G
-------------
E
------------
F
A
P
F
E
---------------
E
I
K
K
Y
E
S
--
L
I
E
E
-------------
Q
I
P
-----------------
Y
--
A
-------------
N
----
Y
E
----------
S
--------
V
R
N
--
A
---
V
F
S
L
E
------------
K
R
--
L
A
D
-
L
-
G
V
-
D
-
R
K
S
--------
C
H
I
D
L
V
P
E
N
F
I
E
-----
S
P
-------
Q
G
-
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
------------------
A
---------------
L
F
L
------------------
E
S
------------------
E
---------
F
------------------
T
------------------
S
Q
E
-------------------------------------
E
E
T
F
L
S
H
Y
E
S
-------------
D
----------
Q
---------------
T
----------
P
V
S
H
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
E
E
Q
G
-----
E
D
F
G
D
Y
G
V
N
R
Y
Q
R
A
V
-
K
G
L
A
S
Y
G
-------------------
180
HHSearch
62.74
20%
27
- C3 -
-
4R78
2
?
A:
[24-304]
-----------------------------------------
I
I
K
E
K
I
S
S
L
-
L
----
S
Q
E
E
---
E
V
--
L
S
V
E
Q
L
-
G
G
M
T
N
Q
N
-
Y
L
A
K
T
---------
T
---------
N
----------
K
Q
Y
I
V
K
F
F
G
K
G
T
E
K
L
--
I
N
R
Q
D
E
K
Y
N
L
E
-
L
L
--
K
--
D
L
G
L
D
V
K
-----
N
Y
L
F
D
I
E
A
G
I
K
--
V
-------
N
E
Y
I
E
S
---
A
I
T
L
D
-------------
S
T
--
S
-
I
K
-----
T
K
F
D
---
K
I
A
P
I
L
Q
T
I
H
T
S
----------
A
K
-----
E
----
L
R
G
-------------
E
------------
F
A
P
F
E
---------------
E
I
K
K
Y
E
S
--
L
I
E
E
-------------
Q
I
P
-----------------
Y
--
A
-------------
N
----
Y
E
----------
S
--------
V
R
N
--
A
---
V
F
S
L
E
------------
K
R
--
L
A
D
-
L
-
G
V
-
D
-
R
K
S
--------
C
H
I
D
L
V
P
E
N
F
I
E
-----
S
P
-------
Q
G
-
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
------------------
A
---------------
L
F
L
------------------
E
S
------------------
E
---------
F
------------------
T
------------------
S
Q
E
-------------------------------------
E
E
T
F
L
S
H
Y
E
S
-------------
D
----------
Q
---------------
T
----------
P
V
S
H
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
E
E
Q
G
-----
E
D
F
G
D
Y
G
V
N
R
Y
Q
R
A
V
-
K
G
L
A
S
Y
G
-------------------
182
HHSearch
61.41
18%
3
- C3 -
-
2QG7
-
?
E:
[110-453]
----------------------------------------------------------------
S
--
L
E
F
Q
I
I
N
G
-
I
T
N
I
L
-
I
K
V
K
D
---------
M
SK-------
Q
----------
A
K
Y
L
I
R
L
Y
G
P
K
T
D
E
I
--
I
N
R
E
R
E
K
K
I
S
C
-
I
L
--
Y
--
N
K
N
I
A
K
K
-----
I
Y
V
F
F
T
N
--
G
R
--
I
-------
E
E
F
M
D
G
---
Y
-
A
L
S
-------------
R
E
D
I
K
-
N
P
-----
K
F
Q
K
---
L
I
A
K
N
L
K
L
L
H
D
I
----------
K
L
----
N
E
----
N
L
Y
KELQVTQKVPGTR
P
------------
S
F
L
W
N
---------------
T
I
W
K
Y
F
H
--
L
L
N
E
-------------
E
R
K
K--------
I
-------
C
--
S
FDAKANI------
L
K---
L
I
----------
D
--------
F
D
V
--
L
RDS
I
V
E
V
E
------------
S
L
--
C
K
R
-
E
-
N
S
-
P
-
I
V
L
--------
C
H
C
D
L
L
S
S
N
I
I
N
-----
T
V
-
G
G-----
D
-
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
------------------
N
---------------
H
F
N
------------------
E
Y
------------------
A
GFNCDWDLT
P
------------------
S
------------------
K
E
E
-------------------------------------
E
Y
H
F
I
M
H
Y
L
G
-------------
T
----------
D
D
--------------
E
ELI-------
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
G
M
H
S
S
---
D
F
D
F
I
N
Y
G
M
T
R
L
T
A
S
C
-
L
P
I
-----------------------
8
PsiBlast_PDB
61.28
19%
9
- C2 -
-
2IG7
-
CHKB_HUMAN
A:
[71-379]
----------------------------------------------------------
Q
P
---
E
E
--
L
R
V
Y
P
V
S
G
G
L
S
N
L
L
-
F
R
C
S
L
PDHLPSVGE
E
---------
P
----------
R
E
V
L
L
R
L
Y
G
A
I
L
-
Q
G
--
V
D
S
L
V
L
E
S
V
M
F
A
I
L
--
A
--
E
R
S
L
G
P
Q
-----
L
Y
G
V
F
P
E
G
R
L
E
-----------
Q
Y
I
P
S
---
R
-
P
L
K
-------------
T
Q
E
L
R
-
E
P
-----
V
L
S
A
---
A
I
A
T
K
M
A
Q
F
H
G
M
----------
E
M
PFTK
E
P
HW
L
-
F
G
T
-------------
M
------------
E
R
Y
L
K
---------------
Q
I
Q
D
L
P
--------------------
M
N
L
---------
L
-------
E
--
M
-------------
Y
----
S
L
----------
K
--------
D
E
M
-------
G
N
L
R
------------
K
L
--
L
-
E
-
S
-
T
P
-
S
P
V
V
F
--------
C
H
N
D
I
Q
E
G
N
I
L
L
LS----------------
L
M
L
V
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
W
V
YDYTHEEWPFY
K
---------------
A
R
P
------------------
T
D
------------------
Y
---------
P
------------------
T
------------------
Q
E
Q
-------------------------------------
Q
L
H
F
I
R
H
Y
L
A
E
A
K
KG
E
T
L
S
Q
E
E
Q
R
----------
K
L
--------------
E
----------
E
D
L
L
V
E
V
S
R
Y
A
L
A
S
H
F
F
W
G
L
W
S
I
L
Q
A
S
M
S
T
--
I
E
F
G
Y
L
D
Y
------------------------------------
181
HHSearch
61.21
18%
5
- C3 -
-
2QG7
-
?
D:
[110-453]
----------------------------------------------------------------
S
--
L
E
F
Q
I
I
N
G
G
-
T
N
I
L
-
I
K
V
K
D
---------
M
SK-------
Q
----------
A
K
Y
L
I
R
L
Y
G
P
K
T
D-----
N
R
E
R
E
K
K
I
S
C
-
I
L
--
Y
--
N
K
N
I
A
K
K
-----
I
Y
V
F
F
T
N
--
G
R
--
I
-------
E
E
F
M
D
G
---
Y
-
A
L
S
-------------
R
E
D
I
K
-
N
P
-----
K
F
Q
K
---
L
I
A
K
N
L
K
L
L
H
D
I
----------
K
L
----
N
E
----
N
L
Y
KELQVTQKVPGTR
P
------------
S
F
L
W
N
---------------
T
I
W
K
Y
F
H
--
L
L
N
E
-------------
E
R
K
K--------
I
-------
C
--
S
FDAKANI------
L
K---
L
I
----------
D
--------
F
D
V
--
L
RDS
I
V
E
V
E
------------
S
L
--
C
K
R
-
E
-
N
S
-
P
-
I
V
L
--------
C
H
C
D
L
L
S
S
N
I
I
N
-----
T
V
-
G
------
D
-
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
------------------
N
---------------
H
F
N
------------------
E
Y
------------------
A
GFNCDWDLT
P
------------------
S
------------------
K
E
E
-------------------------------------
E
Y
H
F
I
M
H
Y
L
G
-------------
T
----------
D
D
--------------
E
ELI-------
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
G
M
H
S
S
---
D
F
D
F
I
N
Y
G
M
T
R
L
T
A
S
C
-
L
P
I
-----------------------
2
PsiBlast_PDB
60.19
21%
15
- C2 -
-
2CKO
1
CHKA_HUMAN
A:
[54-373]
---------------------------------------------------------
W
R
G
LRE
D
E
--
F
H
I
S
V
I
R
G
G
-
S
N
M
L
-
F
Q
C
S
L
PDTTATLGD
E
---------
P
----------
R
K
V
L
L
R
L
Y
G
A
I
----------
M
V
L
E
S
V
M
-
F
A
I
L
A
--
E
R
S
L
G
P
K
-----
L
Y
G
I
F
P
Q
G
R
L
E
--
Q
-------
F
---
I
P
S
--
R
-
R
L
D
-------------
T
E
E
L
S
-
L
P
-----
D
I
S
A
---
E
I
A
E
K
M
A
T
F
H
G
M
----------
K
M
-----
P
----
F
N
K
-------------
E
PKW
L
F
G
T
M
E
K
Y
L
K
E
V
L
R
---------------
I
K
F
T
E
E
S
--
R
I
K
K
-------------
L
H
K
---------
L
-------
L
--
S
-------------
Y
----
N
L
----------
P
--------
L
E
L
E
N
L
---
R
S
L
L
E
------------------
S
-
T
-
P
S
-
P
-
V
V
F
--------
C
H
N
D
C
Q
E
G
N
I
L
L
LEGRE
N
S
-
E
-----
K
Q
-
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
--------------------------------------------------------
N
------------------
H
---------
F
------------------
C
------------------
E
W
M
Y
DYSYEKYPF
F
R
A
N
IRKYPT
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
QN
D
F
E
N
L
S
T
E
E
K
-------------
S
----------
I
I
--------------
K
----------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
--
I
E
F
G
Y
M
D
Y
------------------------------------
191
HHSearch
59.64
19%
11
- C3 -
-
3MES
2
?
B:
[52-408]
----------------------------------------
E
I
I
I
G
I
C
R
K
N
I
P
----
G
W
K
E
INE
S
Y
--
I
E
V
K
Q
I
F
S
G
L
T
N
Q
L
-
F
V
V
S
I
---------
V
---------
N
ELKH------
P
R
I
L
F
R
I
Y
G
K
H
V
--
F
--
Y
D
S
K
V
E
L
D
V
F
R
-
Y
L
--
S
--
N
I
N
I
A
P
N
-----
I
I
A
D
F
P
E
--
G
R
--
I
-------
E
E
F
I
D
G
---
E
-
P
L
T
-------------
T
K
Q
L
Q
-
L
T
-----
H
I
C
V
---
E
V
A
K
N
M
G
S
L
H
I
I
----------
N
S
----
K
R
----
A
D
F
PSRFDK-------
E
------------
P
I
L
F
K
---------------
R
I
Y
L
W
R
E
--
E
A
K
I
-------------
Q
V
S
K
NNQID
K
E
L
Y
-------
S
--
K
-------------
I
----
L
E
----------
E
--------
I
D
Q
--
L
---
E
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
--
L
Y
S
-
P
-
A
F
-
S
-
L
V
F
--------
A
H
N
D
L
Q
E
N
N
L
L
Q
-----
T
Q
--------
N
-
N
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
A
D
I
A
------------------
N
---------------
Y
F
C
------------------
E
Y
------------------
I
---------
Y
------------------
D
YCSEKQPY
F
K
F
K
YEDYPC
E
E
L
-------------------------------------
R
K
L
F
I
S
V
Y
L
S
-------------
Q
----------
T
L
--------------
Q
EQVMPSQ
Q
I
V
H
I
M
T
K
A
V
E
V
F
T
L
I
S
H
I
T
W
G
L
W
S
I
A
-----
S
--
V
E
F
D
F
T
E
Y
A
N
T
R
F
T
H
Y
L
-
Q
K
K
K
E
---------------------
152
Fugue
59.52
16%
-15
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-------------G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
G
A
W
-
K
----
T
V
P
L
---
E
H
--
L
R
I
S
R
I
K
G
G
M
S
N
M
L
-
F
L
C
R
L
S
EVYPPIRN
E
---------
P
----------
N
K
V
L
L
R
V
Y
F
N
P
E
-
T
E
--
S
H
L
V
A
E
S
V
I
F
T
-
L
L
--
S
--
E
R
H
L
G
P
K
-----
L
Y
G
I
F
S
--
G
G
R
--
L
-------
E
E
Y
I
P
S
R
--
P
--
L
S
-------------
C
H
E
I
S
-
L
A
-----
H
M
S
T
---
K
I
A
K
R
V
A
K
V
H
Q
L
----------
E
V
----
P
I
----
W
K
E
-------------
P
------------
D
Y
L
C
E
---------------
A
L
Q
R
W
L
K
--
Q
L
T
G
T
V
DAE
H
R
F
D
L
PEE
C
G
V
---------
S
-------
S
--
V
-------------
N
----
C
L
----------
D
--------
L
A
R
--
E
---
L
E
F
L
R
------------
A
H
--
I
-
S
-
L
-
S
K
S
P
-
V
T
F
--------
C
H
N
D
L
Q
E
G
N
I
L
L
-----
P
K
-
R
---------
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
------------------
N
---------------
H
F
I
E
W
T
IDYDIDEAPF
Y
K
I
Q
T
E
N
------------------
F
---------
P
------------------
E
------------------
N
D
Q
-------------------------------------
M
L
E
F
F
L
N
Y
L
R
-------------
E
Q
GNTRENE
L
Y
K
K
--------------
S
----------
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
--
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
-
K
-------------
H
K
Q
L
L
K
N
L
A
---
166
Fugue
58.66
18%
2
- C3 -
-
4OCV
2
?
A:
[24-378]
---------------------------------------
T
N
E
A
L
F
D
V
A
S
H
-
F
----
A
L
E
G
---
T
V
--
D
S
I
E
P
Y
G
D
G
H
I
N
T
T
-
Y
L
V
T
T
---------
D
---------
G
----------
P
R
Y
I
L
Q
R
M
N
T
G
I
-
F
P
--
D
T
V
N
L
M
R
N
V
E
L
-
V
T
--
S
--
T
L
K
A
Q
G
K
E
T
L
D
I
V
R
T
T
S
G
D
T
W
A
E
--
I
DG
G
A
W
R
V
Y
K
F
I
E
----
H
-
T
M
S
-------------
Y
N
L
V
P
-
N
P
-----
D
V
F
R
---
E
A
G
R
A
F
G
D
F
Q
N
F
L
S
G
FDANQLT
E
T
----
I
A
HFHD
T
P
H
-------------
R
------------
F
E
D
F
K
---------------
K
A
L
A
A
D
E
LG
R
A
A
G
-------------
C
G
P
---------
E
-------
I
--
E
-------------
F
----
Y
L
----------
S
--------
H
A
D
--
Q
---
Y
A
V
V
M
------------
D
G
--
L
-
R
D
G
-
S
I
-
P
-
L
R
V
--------
T
H
N
D
T
K
L
N
N
I
L
M
-----
D
A
-
T
-----
T
G
K
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
------------------
D
S
I
R
F
GASTALEDERD
L
D
K
------------------
V
H
------------------
F
---------
S
------------------
T
------------------
E
L
F
-------------------------------------
R
A
Y
T
E
G
F
V
G
E
L
R
-----------
D
----------
S
I
--------------
T
----------
A
R
E
A
E
L
L
P
F
S
G
N
L
L
T
M
E
C
G
M
R
F
L
A
D
Y
L
E
G
D
--
V
Y
F
A
T
-
K
Y
P
E
H
N
L
V
R
S
R
T
Q
I
K
L
V
R
E
M
E
Q
R
A
D
E
T
R
A
I
V
A
D
V
M
E
T
T
167
SP3
57.88
14%
-8
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-----------------G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
-
G
GAWK
T
V
P
L
---
E
H
--
L
R
I
S
R
I
K
G
G
M
S
N
M
L
-
F
L
C
R
L
---------
S
---------
E
VYPPIRNEP-
N
K
V
L
L
R
V
Y
F
N
P
E
-
T
E
--
S
H
L
V
A
E
S
V
I
F
T
-
L
L
--
S
--
E
R
H
L
G
P
K
-----
L
Y
G
I
F
S
G
--
G
R
--
L
-------
E
E
Y
I
P
S
---
R
-
P
L
S
-------------
C
H
E
I
S
-
L
A
-----
H
M
S
T
---
K
I
A
K
R
V
A
K
V
H
Q
L
----------
E
V
----
P
I
----
W
K
E
-------------
P
------------
D
Y
L
C
E
---------------
A
L
Q
R
W
L
K
--
Q
L
T
G
-------------
T
V
D
---------
A
-------
E
--
H
R
F
D
L
PEECGVSSV
N
----
C
L
----------
D
--------
L
A
R
--
E
---
L
E
F
L
R
------------
A
H
--
I
-
S
-
L
S
K
S
-
P
-
V
T
F
--------
C
H
N
D
L
Q
E
G
N
I
L
L
-----
P
K
-
R
---------
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
------------------
N
---------------
H
F
I
------------------
E
W
T
IDYDIDEAPF
Y
K
I
Q
TEN
F
---------
P
------------------
E
------------------
N
D
Q
-------------------------------------
M
L
E
F
F
L
N
Y
L
R
-------------
E
----------
Q
G
--------------
N
TRENE
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
--
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
-
K
-----
H
K
Q
L
L
K
N
L
A
-----------
184
HHSearch
57.60
16%
5
- C3 -
-
1NW1
-
CKA2_CAEEL
B:
[75-419]
----------------------------------------------------------------
H
--
L
R
I
S
R
I
K
G
G
M
S
N
M
L
-
F
L
C
R
L
---------
S
EVYPPIRNE
P
----------
N
K
V
L
L
R
V
Y
F
N
P
E
-
T
E
--
S
H
L
V
A
E
S
V
I
F
T
-
L
L
--
S
--
E
R
H
L
G
P
K
-----
L
Y
G
I
F
S
--
G
G
R
--
L
-------
E
E
Y
I
P
S
---
R
-
P
L
S
-------------
C
H
E
I
S
-
L
A
-----
H
M
S
T
---
K
I
A
K
R
V
A
K
V
H
Q
L
----------
E
V
----
P
I
----
W
K
E
-------------
P
------------
D
Y
L
C
E
---------------
A
L
Q
R
W
L
K
--
Q
L
T
G
-------------
T
V
D
---------
A
E------
H
R
F
D
-------------
L
----
P
E
ECGVSSVN
C
L
D
--------
L
A
R
--
E
---
L
E
F
L
R
------------
A
H
--
I
S
L
-
S
-
K
S
-
P
-
V
T
F
--------
C
H
N
D
L
Q
E
G
N
I
L
L
-----
P
K
----------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
------------------
N
---------------
H
F
I
------------------
E
W
------------------
T
---------
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
D
Q
-------------------------------------
M
L
E
F
F
L
N
Y
L
R
-------------
E
----------
Q
G
--------------
N
TRENE
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
--
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
-
K
H
K
-----------------------
183
HHSearch
57.10
16%
9
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[75-419]
----------------------------------------------------------------
H
--
L
R
I
S
R
I
K
G
G
M
S
N
M
L
-
F
L
C
R
L
---------
S
EVYPPIRNE
P
----------
N
K
V
L
L
R
V
Y
F
N
P
E
-
T
E
--
S
H
L
V
A
E
S
V
I
F
T
-
L
L
--
S
--
E
R
H
L
G
P
K
-----
L
Y
G
I
F
S
--
G
G
R
--
L
-------
E
E
Y
I
P
S
---
R
-
P
L
S
-------------
C
H
E
I
S
-
L
A
-----
H
M
S
T
---
K
I
A
K
R
V
A
K
V
H
Q
L
----------
E
V
----
P
I
----
W
K
E
-------------
P
------------
D
Y
L
C
E
---------------
A
L
Q
R
W
L
K
--
Q
L
T
G
-------------
T
V
D
---------
A
E------
H
R
F
D
-------------
L
----
P
E
ECGVSSVN
C
L
D
--------
L
A
R
--
E
---
L
E
F
L
R
------------
A
H
--
I
S
L
-
S
-
K
S
-
P
-
V
T
F
--------
C
H
N
D
L
Q
E
G
N
I
L
L
-----
P
K
----------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
------------------
N
---------------
H
F
I
------------------
E
W
------------------
T
---------
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
D
Q
-------------------------------------
M
L
E
F
F
L
N
Y
L
R
-------------
E
----------
Q
G
--------------
N
TRENE
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
--
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
-
K
H
K
-----------------------
1
PsiBlast_PDB
56.57
25%
-16
- C- -
-
3DXQ
-
?
A:
[27-282]
--------------------------------------------------------------------------
G
G
L
T
N
L
V
-
F
R
A
G
--------------------------------
D
L
C
L
R
I
P
G
K
----
Y
--
I
N
R
A
N
E
A
V
A
A
R
-
E
A
--
A
--
K
A
G
V
S
P
E
-----
V
L
H
V
D
P
A
T
G
V
M
--
V
-------
T
R
Y
I
A
G
A
--
Q
-
T
M
S
P
E
K
F
K
T
R
PG
S
P
A
R
A
G
E
A
F
-
R
K
L
H
G
SG
A
V
F
P
F
R
F
E
L
F
A
M
I
D
D
Y
--------------
L
----
K
V
----
L
S
---------------------------
N
V
T
L
P
---------------
A
G
Y
H
D
V
V
--
R
E
A
G
-------------
G
--------------------------------------------------------------------------
V
R
------------
S
A
--
L
-
A
-
A
-
H
P
L
P
-
L
A
A
--------
C
H
C
D
P
L
C
E
N
F
L
D
-----
T
G
-
E
-----
R
M
---
W
I
V
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
------------------
D
---------------
L
S
V
------------------
E
G
------------------
K
---------
F
------------------
N
------------------
A
N
Q
-------------------------------------
D
E
E
L
M
R
A
Y
F
G
-------------
G
----------
E
A
--------------
R
----------
P
A
E
R
G
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
I
Q
L
A
N
D
N
--
P
V
D
D
F
R
A
Y
A
D
G
R
F
A
R
C
K
---------------------------
153
Fugue
55.84
15%
5
- C3 -
-
2QG7
-
?
A:
[50-458]
YPITESNLRILEGED
R
S
E
K
A
K
E
L
L
K
K
Y
VSNVFEN
E
K
T
L
Y
I
Y
C
K
Y
V
M
L
H
Y
G
-
K
----
D
L
V
N
---
P
N
EV
D
S
L
E
F
Q
I
I
N
G
T
N
I
L
-
I
K
V
K
D
MS-------
K
---------
Q
----------
A
K
Y
L
I
R
L
Y
G
P
T
D
-
E
I
--
I
N
R
E
R
E
K
K
I
S
C
-
I
L
--
Y
--
N
K
N
I
A
K
K
-----
I
Y
V
F
F
T
N
G
--
R
--
I
-------
E
E
F
M
D
G
---
Y
-
A
L
S
-------------
R
E
D
I
K
-
N
P
-----
K
F
Q
K
---
L
I
A
K
N
L
K
L
L
H
D
I
----------
K
L
----
N
E
----
N
L
Y
-------------
K
------------
E
L
Q
V
T
QKVPGTRPSF
L
W
N
T
I
W
K
Y
F
H
L
L
--
N
E
E
R
-------------
K
K
I
---------
C
-------
S
--
F
-------------
D
----
A
K
----------
A
--------
N
I
L
--
K
L
ID
F
D
V
L
R
------------
D
S
--
I
-
V
-
E
-
V
E
-
S
-
L
C
K
R
E
NSPIVL
C
H
C
D
L
L
S
S
N
I
I
N
-----
T
V
G
E
-----
G
D
-
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
------------------
N
H
F
N
E
Y
AGFN------
C
D
W
------------------
D
L
------------------
T
---------
P
------------------
S
------------------
K
E
E
-------------------------------------
E
Y
H
F
I
M
H
Y
L
G
-------------
T
----------
D
D
--------------
E
----------
E
L
I
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
G
M
--
H
S
F
D
F
I
N
Y
G
M
T
R
L
T
A
S
C
-
L
P
I
F
R
S
K
V
------------------
159
Fugue
45.21
15%
25
- C3 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
--------------------------------------
A
K
M
R
I
S
P
E
L
K
K
L
-
I
-----------
E
K
--
Y
R
C
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
G
---------
E
---------
N
----------
E
N
L
Y
L
K
M
T
D
S
R
Y
-
K
G
--
T
T
Y
D
V
E
R
E
K
D
M
-
M
L
--
W
L
E
G
K
L
P
V
P
K
-----
V
L
H
F
E
R
H
D
G
W
S
N
L
L
-------
M
S
E
A
D
G
V
L
C
S
-
E
E
Y
-------------
E
D
E
Q
S
-
P
E
-----
K
I
I
E
---
L
Y
A
E
C
I
R
L
F
H
S
I
----------
D
I
----
S
D
----
C
P
Y
-------------
T
------------
N
S
L
D
S
---------------
R
L
A
E
L
D
Y
--
L
L
N
N
-------------
D
L
A
---------
D
-------
V
--
D
-------------
C
----
E
N
----------
W
EEDTPFKD
P
R
E
--
L
---
Y
D
F
L
K
------------
T
E
--
K
-
P
---
E
E
-
E
-
L
V
F
--------
S
H
G
D
L
G
D
S
N
I
F
V
-----
K
D
-
G
------
K
-
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
------------------
F
---------------
C
V
R
------------------
S
I
------------------
R
---------
E
D
IG---------------
E
------------------
E
Q
Y
-------------------------------------
V
E
L
F
F
D
L
L
G
I
-------------
K
----------
P
D
--------------
W
----------
E
K
I
K
Y
Y
I
L
L
D
E
L
F
---------------------------------------------------------------