@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : D5Q4H0_CLODI: (2019-01-27 )
MDIISRKYINEGFNSKAYIINDDYILLDGVNQNSYKNYQKYVNVINQISNVKSLEIPRIIELIEPCEEYPNGALIYKMIKGHTFRKEHIEIVNLDNIAKKLAEFMDELYEIRVDFDKDEYIKNELEITEQSVIELKEYLSESNYEKILSWFNEYKNYLLTFNDYHFIHGDLWYENYILNDNNELVGIVDFEGSGMGDPAYDIAALYYLGTGFINKVLSYYKYTDEDLIKRVSMLIKAREIADFDDMVKNYPEEVEEQVDKIKKVL
Atome Classification :
(21 SA)
.........10........20---........30..-......40........50--........60........70........80.-......-.-90.--.---.---......100.......110.......120----......---.---.130-..-.----...--...----140---........150....-.--.--.-160...-....170.......-180-...---......190.......200.....----.-----.----.210.......220.--....-..230.......240......-.250.......260...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MD
I
I
S
R
K
Y
I
NEGFNS
K
A
Y
I
IN---D
D
Y
I
L
L
DGVNQ
N
-
S
Y
K
N
Y
Q
K
Y
V
N
V
I
N
Q
ISNV--KSL
E
I
P
R
I
I
E
L
I
E
P
C
E
EYPN
G
A
L
I
Y
K
M
IKGH-TF
R
K
E
H
-
I
-
E
-
I
--
V
---
N
---
L
D
N
I
A
K
K
L
A
E
F
M
D
E
L
Y
E
I
RVDFD
K
D
E
Y
I
-----
K
N
E
L
E
I
---
T
---
E
Q
---
S
V
-
I
----
E
L
K
--
E
Y
L
----
S
E----S
N
Y
E
K
I
L
S
W
F
N
E
YK
N
-
Y
--
L
--
L
-TFN
D
Y
H
-
F
I
H
G
D
L
W
Y
E
N
Y
I
LN-D---NN
E
---
L
V
G
I
V
DFEGSGMGD
P
A
Y
D
-
I
A
A
L
Y
----
Y
-----
L
----
G
T
G
F
I
N
K
V
L
S
Y
YKYT--
D
E
D
L
-
I
K
R
V
S
M
L
I
K
A
R
EIA
D
F
D
D
M
V
K
-N
Y
P
E
E
V
E
E
Q
V
D
K
I
K
K
VL
57
HHSearch
92.88
23%
-11
- C- -
-
3N4U
-
?
A:
[22-297]
--
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
I
N
---
R
D
F
I
F
K
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
-
P
L
T
P
L
L
-
L
N
N
-
L
--
P
K
Q
-
S
---
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
-----
L
D
F
R
E
K
---
I
---
N
E
---
D
N
-
K
----
K
I
K
--
K
L
L
S
REL
K
G
----
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
-
N
--
E
IY
F
-
K
-
Y
Y
P
C
-
L
I
H
N
D
F
S
S
D
H
I
L
F
D
-
T
E--
K
N
T
---
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
-
F
I
S
L
M
----
E
DDEE-
Y
----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D-
I
P
T
V
-
L
E
K
Y
R
M
K
E
K
Y
W
S
F
E
K
I
I
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
I
R
S
--
69
HHSearch
90.65
23%
5
- C1 -
-
3HAM
3
?
A:
[18-287]
--
I
N
E
L
R
Y
L
S
S
G
D
D
S
D
T
F
L
C
N
---
E
Q
Y
V
V
K
V
P
K
R
D
S
-
V
R
I
S
Q
K
R
E
F
E
L
Y
R
F
L
E
N
C
K-
L
S
Y
Q
I
P
A
V
V
Y
Q
-------
S
D
R
F
N
I
M
K
Y
I
K
G
E
-
R
I
T
Y
E
Q
-
Y
H
K
-
L
--
S
E
K
-
E
---
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
D
C
S
V
S
L
F
S
DALV-
N
K
K
D
K
F
---
L
Q
D
K
K
L
---
L
I
-
S
----
I
L
E
K
E
Q
L
L
----
T
D
----
E
M
L
E
H
I
E
T
I
Y
E
N
I
L
N
-
N
AV
L
--
F
-
K
-
Y
T
P
C
-
L
V
H
N
D
F
S
A
N
N
M
I
F
R
-----
N
N
R
---
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
-
F
L
C
L
L
----
D
CSTDD
F
----
G
K
E
F
G
R
K
V
L
K
Y
Y
Q
H
K
A-
P
E
V
A
-
E
R
K
A
E
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
E
R
K
D
R
E
M
L
I
K
G
V
S
------
1
PsiBlast_PDB
90.49
23%
-15
- C1 -
-
3TDW
1
?
A:
[19-272]
I
S
I
Q
S
V
E
S
L
G
E
G
F
R
N
Y
A
I
L
V
N
---
G
D
W
V
F
R
F
P
K
S
Q
Q
-
G
A
D
E
L
N
K
E
I
Q
L
L
P
L
L
V
G
C
--
V
K
V
N
I
P
Q
Y
V
Y
I
G
K
R
S
D
G
N
P
--
F
V
G
Y
R
K
V
Q
G
Q
-
I
L
G
E
D
G
-
M
-
A
-
V
--
L
P
D
D
A
---
K
D
R
L
A
L
Q
L
A
E
F
M
N
E
L
S
A
F
P
V
E
T
A
I
S
A
G
V
P
V
T
N
L
K
N
K
I
L
L
---
L
---
S
E
---
A
V
E
D
----
Q
V
F
--
P
L
L
----
D
E
----
S
L
R
D
Y
L
T
L
R
F
Q
S
Y
M
T
-
H
--
P
--
V
Y
T
R
Y
T
P
R
-
L
I
H
G
D
L
S
P
D
H
F
L
T
N
-
L
---
N
S
R
QTP
L
T
G
I
I
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
V
Y
L
L
E
----
D
-----
C
----
G
E
L
F
T
R
Q
V
M
A
Y
R
G
E
V
--
D
L
D
T
H
I
R
K
V
S
L
F
V
T
F
D
Q
V
S
-------------------------
2
PsiBlast_PDB
89.66
23%
-14
- C1 -
-
3TDV
1
?
A:
[19-272]
I
S
I
Q
S
V
E
S
L
G
E
G
F
R
N
Y
A
I
L
V
N
---
G
D
W
V
F
R
F
P
K
S
Q
Q
-
G
A
D
E
L
N
K
E
I
Q
L
L
P
L
L
V
G
C
--
V
K
V
N
I
P
Q
Y
V
Y
I
G
K
R
S
D
G
N
P
--
F
V
G
Y
R
K
V
Q
G
Q
-
I
L
G
E
D
G
-
M
-
A
-
V
--
F
---
P
D
D
A
K
D
R
L
A
L
Q
L
A
E
F
M
N
E
L
S
A
F
P
V
E
T
A
I
S
A
G
V
P
V
T
N
L
K
N
K
I
L
L
---
L
---
S
E
---
A
V
E
D
----
Q
V
F
--
P
L
L
----
D
E
----
S
L
R
D
Y
L
T
L
R
F
Q
S
Y
M
T
-
H
--
P
--
V
Y
T
R
Y
T
P
R
-
L
I
H
G
D
L
S
P
D
H
F
L
T
N
-
L
---
N
S
R
QTP
L
T
G
I
I
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
V
Y
L
L
E
----
D
-----
C
----
G
E
L
F
T
R
Q
V
M
A
Y
R
G
E
V
--
D
L
D
T
H
I
R
K
V
S
L
F
V
T
F
D
Q
V
S
-------------------------
59
HHSearch
88.10
21%
-13
- C1 -
-
3TDW
1
?
A:
[21-294]
--
I
Q
S
V
E
S
L
G
E
G
F
R
N
Y
A
I
L
V
N
---
G
D
W
V
F
R
F
P
K
S
Q
Q
-
G
A
D
E
L
N
K
E
I
Q
L
L
P
L
L
V
G
C
--
V
K
V
N
I
P
Q
Y
V
Y
I
G
K
R
--
S
D
G
N
P
F
V
G
Y
R
K
V
Q
G
Q
-
I
L
G
E
D
G
-
M
-
A
V
L
P
D
D
---
A
---
K
D
R
L
A
L
Q
L
A
E
F
M
N
E
L
S
A
F
P
V
E
T
A
I
S
A
G
V
P
V
---
T
N
L
K
N
K
---
I
---
L
L
---
L
S
-
E
A
V
E
D
Q
V
F
--
P
L
L
----
D
E
----
S
L
R
D
Y
L
T
L
R
F
Q
S
Y
M
T
-
H
PV
Y
--
T
-
R
-
Y
T
P
R
-
L
I
H
G
D
L
S
P
D
H
F
L
T
N
-
L
NSR
Q
T
P
---
L
T
G
I
I
D
F
G
D
A
A
I
S
D
P
D
Y
D
-
Y
V
Y
L
L
----
E
D----
C
----
G
E
L
F
-
T
R
Q
V
M
A
Y
R
G
E
VD
L
D
T
H
-
I
R
K
V
S
L
F
V
T
F
D
Q
V
S
Y
L
L
E
G
L
R
A
R
D
Q
D
W
I
S
E
G
L
E
L
L
E
---
61
HHSearch
87.55
23%
-11
* C1 *
-
5IQC
2
AACA_STAAU
A:
[28-300]
--
V
D
S
I
E
I
I
G
S
G
Y
D
S
V
A
Y
L
V
N
---
N
E
Y
I
F
K
T
K
F
S
T
N
-
K
K
K
G
Y
A
K
E
K
A
I
Y
N
F
L
N
T
N
LE
T
N
V
K
I
P
N
I
E
Y
S
Y
I
S
---
D
E
L
S
I
L
G
Y
K
E
I
K
G
T
-
F
L
T
P
E
I
-
Y
S
T
-
M
--
S
E
E
-
E
---
Q
N
L
L
K
R
D
I
A
S
F
L
R
Q
M
H
G
L
D
Y
T
D
I
S
E
C
T
I
-----
D
N
K
Q
N
V
L
E
E
Y
---
I
L
---
L
R
-
E
----
T
I
Y
--
N
D
L
----
T
D
----
I
E
K
D
Y
I
E
S
F
M
E
R
L
N
A
T
T
--
V
--
F
-
E
-
G
K
K
C
-
L
C
H
N
D
F
S
C
N
H
L
L
L
D
-
G
---
N
N
R
---
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
-
F
I
Y
L
L
----
E
DSEEE
I
----
G
T
N
F
G
E
D
I
L
R
M
Y
G
N
I
D-
I
E
K
A
-
K
E
Y
Q
D
I
V
E
E
Y
Y
P
I
E
T
I
V
Y
G
I
K
N
I
K
Q
E
F
I
E
N
G
R
K
E
I
Y
K
--
16
PsiBlast_PDB
86.47
25%
-12
- C1 -
-
3SG8
1
?
A:
[29-256]
---------
G
E
G
N
D
C
I
A
Y
E
I
N
---
R
D
F
I
F
K
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
-
P
L
T
P
L
L
-
L
-
N
-
N
--
L
P
K
Q
S
---
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
-----
L
D
F
R
E
K
---
I
---
N
E
---
D
N
-
K
----
K
I
K
--
K
L
L
----
S
R
ELK
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
-
N
--
E
--
I
-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
---
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
-
F
I
S
L
M
EDDE
E
-----
Y
----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
--
D
-------------------------------------------
17
PsiBlast_PDB
86.26
25%
-8
- C1 -
-
4DTA
1
?
A:
[29-256]
---------
G
E
G
N
D
C
I
A
Y
E
I
N
---
R
D
F
I
F
K
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
A
G
M
T
K
I
K
G
V
-
P
L
T
P
L
L
-
L
-
N
-
N
--
L
P
K
Q
S
---
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
-----
L
D
F
R
E
K
---
I
---
N
E
---
D
N
-
K
----
K
I
K
--
K
L
L
----
S
R
ELK
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
-
N
--
E
--
I
-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
---
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
-
F
I
S
L
M
EDDE
E
-----
Y
----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
--
D
-------------------------------------------
9
PsiBlast_PDB
85.67
25%
-10
- C1 -
-
4DT9
1
?
A:
[29-256]
---------
G
E
G
N
D
C
I
A
Y
E
I
N
---
R
D
F
I
F
K
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
-
P
L
T
P
L
L
-
L
-
N
-
N
--
L
P
K
Q
S
---
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
-----
L
D
F
R
E
K
---
I
---
N
E
---
D
N
-
K
----
K
I
K
--
K
L
L
----
S
R
ELK
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
-
N
--
E
--
I
-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
---
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
-
F
I
S
L
M
EDDE
E
-----
Y
----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
--
D
-------------------------------------------
8
PsiBlast_PDB
85.61
25%
-12
- C1 -
-
4DT8
1
?
A:
[29-256]
---------
G
E
G
N
D
C
I
A
Y
E
I
N
---
R
D
F
I
F
K
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
-
P
L
T
P
L
L
-
L
-
N
-
N
--
L
P
K
Q
S
---
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
-----
L
D
F
R
E
K
---
I
---
N
E
---
D
N
-
K
----
K
I
K
--
K
L
L
----
S
R
ELK
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
-
N
--
E
--
I
-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
---
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
-
F
I
S
L
M
EDDE
E
-----
Y
----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
--
D
-------------------------------------------
7
PsiBlast_PDB
85.43
25%
-9
- C1 -
-
4DTB
1
?
A:
[29-256]
---------
G
E
G
N
D
C
I
A
Y
E
I
N
---
R
D
F
I
F
K
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
A
G
Y
T
K
I
K
G
V
-
P
L
T
P
L
L
-
L
-
N
-
N
--
L
P
K
Q
S
---
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
-----
L
D
F
R
E
K
---
I
---
N
E
---
D
N
-
K
----
K
I
K
--
K
L
L
----
S
R
ELK
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
-
N
--
E
--
I
-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
---
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
-
F
I
S
L
M
EDDE
E
-----
Y
----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
--
D
-------------------------------------------
12
PsiBlast_PDB
85.00
25%
-11
- C1 -
-
3SG9
1
?
A:
[29-256]
---------
G
E
G
N
D
C
I
A
Y
E
I
N
---
R
D
F
I
F
K
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
-
P
L
T
P
L
L
-
L
-
N
-
N
--
L
P
K
Q
S
---
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
-----
L
D
F
R
E
K
---
I
---
N
E
---
D
N
-
K
----
K
I
K
--
K
L
L
----
S
R
ELK
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
-
N
--
E
--
I
-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
---
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
-
F
I
S
L
M
EDDE
E
-----
Y
----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
--
D
-------------------------------------------
62
HHSearch
84.93
22%
-13
- C1 -
-
5IQI
1
AACA_STAAU
C:
[28-299]
--
V
D
S
I
E
I
I
G
S
G
Y
D
S
V
A
Y
L
V
N
---
N
E
Y
I
F
K
T
K
F
S
T
N
-
K
K
K
G
F
A
K
E
K
A
I
Y
N
F
L
N
T
N
LE
T
N
V
K
I
P
N
I
E
Y
S
Y
I
S
---
D
E
L
S
I
L
G
Y
K
E
I
K
G
T
-
F
L
T
P
E
I
-
Y
-
S
T
M
--
S
E
E
-
E
---
Q
N
L
L
K
R
D
I
A
S
F
L
R
Q
M
H
G
L
D
Y
T
D
I
S
E
C
T
I
-----
D
N
K
Q
N
V
---
L
---
E
E
Y
I
L
L
R
-
E
----
T
I
Y
--
N
D
L
----
T
D
----
I
E
K
D
Y
I
E
S
F
M
E
R
L
N
A
T
T
--
V
--
F
-
E
-
G
K
K
C
-
L
C
H
N
D
F
S
C
N
H
L
L
L
D
-
G
---
N
N
R
---
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
-
F
I
Y
L
L
----
E
DSEEE
I
----
G
T
N
F
G
E
D
I
L
R
M
Y
G
N
I
D-
I
E
K
A
-
K
E
Y
Q
D
I
V
E
E
Y
Y
P
I
E
T
I
V
Y
G
I
K
N
I
K
Q
E
F
I
E
N
G
R
K
E
I
Y
---
13
PsiBlast_PDB
84.92
25%
-15
- C1 -
-
6CD7
-
?
A:
[30-257]
---------
G
E
G
N
D
C
I
A
Y
E
I
N
---
R
D
F
I
F
K
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
-
P
L
T
P
L
L
-
L
-
N
-
N
--
L
P
K
Q
S
---
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
-----
L
D
F
R
E
K
---
I
---
N
E
---
D
N
-
K
----
K
I
K
--
K
L
L
----
S
R
ELK
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
-
N
--
E
--
I
-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
---
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
-
F
I
S
L
M
EDDE
E
-----
Y
----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
--
D
-------------------------------------------
70
HHSearch
84.90
22%
3
- C1 -
-
4DCA
1
?
A:
[39-300]
--
I
N
E
L
R
Y
L
S
S
G
D
D
S
D
T
F
L
C
N
---
E
Q
Y
V
V
K
V
P
K
R
D
S
-
V
R
I
S
Q
K
R
E
L
E
L
Y
R
F
L
E
N
C
K-
L
S
Y
Q
I
P
A
V
V
Y
Q
S
-------
D
R
F
N
I
M
K
Y
I
K
G
E
-
R
I
T
Y
E
Q
Y
H
-
K
-
L
--
S
E
K
-
E
---
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
D
C
S
V
S
L
F
S
D
A
LV-
N
K
K
D
K
F
---
L
Q
D
K
K
L
---
L
I
-
S
----
I
L
E
K
E
Q
L
L
----
T
D
----
E
M
L
E
H
I
E
T
I
Y
E
N
I
L
S
-
N
--
A
VL
F
-
K
-
Y
T
P
C
-
L
V
H
N
D
F
S
A
N
N
M
I
F
R
-----
N
N
R
---
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
-
F
L
C
L
L
----
D
CSTDD
F
----
G
K
E
F
G
R
K
V
L
K
Y
Y
Q
H
K
A-
P
E
V
A
-
E
R
K
A
E
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
E
R
K
D
R
--------------
5
PsiBlast_PDB
84.67
25%
-14
- C1 -
-
4DFB
1
?
A:
[50-277]
---------
G
E
G
N
D
C
I
A
Y
E
I
N
---
R
D
F
I
F
K
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
-
P
L
T
P
L
L
-
L
-
N
-
N
--
L
P
K
Q
S
---
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
-----
L
D
F
R
E
K
---
I
---
N
E
---
D
N
-
K
----
K
I
K
--
K
L
L
----
S
R
ELK
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
-
N
--
E
--
I
-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
---
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
-
F
I
S
L
M
----
E
------EEY-
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
--
D
-------------------------------------------
11
PsiBlast_PDB
84.51
25%
-18
- C- -
-
3N4U
-
?
A:
[29-256]
---------
G
E
G
N
D
C
I
A
Y
E
I
N
---
R
D
F
I
F
K
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
-
P
L
T
P
L
L
-
L
-
N
-
N
--
L
P
K
Q
S
---
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
-----
L
D
F
R
E
K
---
I
---
N
E
---
D
N
-
K
----
K
I
K
--
K
L
L
----
S
R
ELK
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
-
N
--
E
--
I
-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
---
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
-
F
I
S
L
M
EDDE
E
-----
Y
----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
--
D
-------------------------------------------
6
PsiBlast_PDB
84.37
25%
-10
- C1 -
-
4DFU
3
?
A:
[50-277]
---------
G
E
G
N
D
C
I
A
Y
E
I
N
---
R
D
F
I
F
K
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
-
P
L
T
P
L
L
-
L
-
N
-
N
--
L
P
K
Q
S
---
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
-----
L
D
F
R
E
K
---
I
---
N
E
---
D
N
-
K
----
K
I
K
--
K
L
L
----
S
R
ELK
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
-
N
--
E
--
I
-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
---
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
-
F
I
S
L
M
----
E
-----
D
DEEY
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
--
D
-------------------------------------------
4
PsiBlast_PDB
84.34
25%
-12
- C1 -
-
4DE4
1
?
A:
[50-277]
---------
G
E
G
N
D
C
I
A
Y
E
I
N
---
R
D
F
I
F
K
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
-
P
L
T
P
L
L
-
L
-
N
-
N
--
L
P
K
Q
S
---
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
-----
L
D
F
R
E
K
---
I
---
N
E
---
D
N
-
K
----
K
I
K
--
K
L
L
----
S
R
ELK
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
-
N
--
E
--
I
-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
---
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
-
F
I
S
L
M
----
E
-----
D
DEEY
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
--
D
-------------------------------------------
19
PsiBlast_PDB
83.25
24%
-13
- C1 -
-
5C4K
1
?
A:
[49-276]
---------
G
K
G
N
D
C
I
A
Y
E
I
N
---
R
D
F
I
F
K
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
V
-
P
L
T
P
L
L
-
L
-
N
-
N
--
L
P
K
Q
S
---
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
-----
L
D
F
R
E
K
---
I
---
N
E
---
D
N
-
K
----
K
I
K
--
K
L
L
----
S
R
ELK
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
-
N
--
E
--
I
-
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
---
K
N
T
---
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
-
F
I
S
L
M
EDDE
E
-----
Y
----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
--
D
-------------------------------------------
67
HHSearch
62.10
19%
14
- C1 -
-
4R78
2
?
A:
[39-277]
--
V
L
S
V
E
Q
L
-
G
G
M
T
N
Q
N
Y
L
A
K
T
TN
K
Q
Y
I
V
K
F
F
G
K
G
T
E
K
L
I
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
---
L
G
L
D
V
K
N
Y
L
F
D
I
------
E
A
G
I
K
V
N
E
Y
I
E
S
A
I
T
L
D
S
T
S
----------------
I
K
T
K
F
D
K
I
A
P
I
L
Q
T
I
H
T
S
A
K
E
L
R
G
E
F
A
P
F
E
E
I
-
K
K
Y
E
S
L
---
I
---
E
E
-----------------
Q
I
----
P
Y
----
A
N
Y
E
S
V
R
N
A
V
F
S
L
E
K
-
R
--
L
A
D
L
-
G
-
V
D
R
K
-
S
C
H
I
D
L
V
P
E
N
F
I
E
S
-
P
---
Q
G
R
---
L
-
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
-
L
A
A
L
F
----
L
E
S
E--
F
----
T
S
Q
E
E
E
T
F
L
S
H
Y
E
S
D
Q-
T
P
V
S
-
H
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
------------------