@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : D5ZQ68_STRVD: (2019-01-27 )
MTHATSLPPELHQWVTRHLTGMDTAAVTDASWPRGASRVWRVRTDHGEVFVKLYPSTEKYEREVQGCEHATRALAADEAPRLLASDPDRPAVVLSALPGRVVRGLPLEQAEEQRVHRLAGGLLRRWHDTPEPIGDREHQRIRASVTAQADEAAVILERLGDQLAPAERNLVRDAAHDLPDLARALPLAYRHGDYSPRNWLWDEAAGHHSLIDFEESAPGLAVEDLVWLCGAAWPTRPDLRDAFLTGYGRLLSSTEQRALVLLTARLGVSYLSTGLTKADTVLIDRGRTVLQHMVRAPR
Atome Classification :
(22 SA)
--.........10........20.------.......30........40-....---------.-.-.-.50..-----..-..---.----.60.....-...70..------.-...--..80--------....-----..--.--------.-----.90----........-100...----..---.----------.-------.110-----.......120-----------...-....130...-----...-..140---.---.-----...-....150.......-.-----160---.-------------.--..---.------...170.......180.--....-----..--..190----------.........200..---..-...-210.......220....----.-..230..-----.-----------------.--..--..240-----------...-....--..250.-.---.-----------.---....--------.----260.........270...-------..-.----.------280-.......290......-----------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--MTHATSL
P
P
E
L
H
Q
W
V
T
R
H
LTGM------DTAAVTDASWPRGA
S
R
V
W
R
-
V
RTD---------H-
G
-
E
-
V
F
V
K
L-----YP-
S
T
---
E
----
K
Y
E
R
E
V
Q
G
-
C
E
H
A
T
R
A
------
L
-
A
AD--EA
P
---------
R
L
LA-----SD--P--------D-----R
P
A
----
V
V
L
SALP
G
-
R
-
V
VRG----LP---L----------
E
-------
Q
A
E
E
-----
Q
R
V
H
R
L
A
G
G
L
-----------
L
R
R
-WHDTP-EPIG-----
D
R
E
-
H
Q
R
-----
I
---
R
-----
A
S
V-TAQA
D
-
E
A
A
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L
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-L-----G-D---Q-------------L--AP---
A
------
E
R
N
L
V
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A
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D
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P
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--
L
--
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AL-----
P
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--
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YR------------HGDYSPRNWLWDEA---AG-HHS-
L
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DFEESAPG
L
A
V
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D
L
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----
W
-
L
CGA-AW-----P-----------------T--RP--
D
L
R
-------------
D
A
F
-
L
T
G
Y
--
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L
--
L
-S---S-----------T---EQ
R
A
--------
L
----
V
--
L
L
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V
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Y
L
S
TGL-------TK-A----
D
------
T
V
L
-IDR
G
R
T
V
L
Q
H
M
VRAPR-----------------------
24
HHSearch
78.20
20%
-31
- C4 -
-
2PPQ
-
KHSE_AGRFC
A:
[7-281]
-------
I
T
E
D
E
L
R
N
F
L
T
Q
-
Y
D
V
G
------
S
L
T
S
Y
K
G
I
A
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----
N
S
N
F
L
-
L
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---------
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----
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-----
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----
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------------------------------
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-----
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---------------------------
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-----
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------------
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A
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----
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--
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--
T
K
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-------------
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A
L
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L
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---
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----
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L
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S
A
L
R
F
F
L
T
R
L
-----------------------------------------------------------------
29
Fugue
75.55
17%
-15
- C4 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
------
T
D
I
T
E
D
E
L
R
N
F
L
T
Q
Y
D
V
G
------
S
L
T
S
Y
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A
----
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S
N
F
L
-
L
H
T
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---------
K
-
D
-
P
-
L
I
L
T
L
-----
Y
E
-
K
K
---
N
----
D
L
P
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F
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G
L
M
Q
H
L
A
A
K
G
------
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-
S
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--
L
P
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---------
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K
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-----
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S---
G
-----
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----
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M
W
-------------------------
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----
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----
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N
A
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W
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FEKDG
A
-----------------
Y
--
N
V
--
T
K
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-------------
K
A
L
-
L
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Y
Q
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--
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---
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--------
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-------
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----
L
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TPAGA
L
V
V
-
K
K
D
P
L
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Y
L
R
K
L
R
F
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R
T
IANVAEYGLA-------------
5
HHSearch
72.76
12%
-15
- C- -
-
3N4U
-
?
A:
[4-299]
-------
Y
T
F
D
Q
V
E
K
A
I
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Q
L
Y
P
D
F
------
T
I
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T
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S
G
E
G
N
-
D
C
I
A
Y
E
-
I
------------
N
-
R
-
D
-
F
I
F
K
F
-----
P
K
-
H
S
R
G
S
T
----
N
L
F
N
E
V
N
I
-
L
K
R
I
H
N
K
------
L
--
P
L
--
P
I
P
---------
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V
V
F
-----
T
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--
M
--------
P
S
ETYQ
M
S
F
----
A
G
F
T
K
I
K
G
-
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-
P
L
T
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----
L
L
L
N
N
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----------
P
-------
K
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-----
N
Q
A
A
K
D
L
A
R
F
-----------
L
S
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-
L
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-----
K
S
N
-
L
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L
-----
D
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--
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-----
E
K
I
-
N
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D
N
K
-
K
I
K
K
L
L
S
R
-------------
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-------------
L
--
K
G
---
P
------
Q
M
K
K
V
D
D
F
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R
D
I
L
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N-
E
I-
Y
F
K
Y
-----
Y
P
--
C
L
I
------------
H
N
D
F
S
S
D
H
I
L
F
D
T
E
K--
N
T
-
I
C
G
-
I
I
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D
A
A
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S
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P
D
N
D
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----
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D
-
D
E
-----
E
-----------------
Y
--
G
M
--
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V
-------------
S
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--
K
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--
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---
P
-----------
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---
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L
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--------
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----
R
--
M
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G
K
-------
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-
G
----
Y
------
M
D
W
-
Y
E
E
G
L
N
E
I
R
S
I
K
---------------------------
10
HHSearch
72.47
16%
-20
- C4 -
-
3TDW
1
?
A:
[4-298]
--------
N
K
L
H
Y
T
T
M
I
M
T
Q
F
P
D
I
------
S
I
Q
S
V
E
S
L
G
E
G
F
-
R
N
Y
A
I
L
-
V
------------
N
-
G
-
D
-
W
V
F
R
F
-----
P
K
-
S
Q
Q
G
A
D
----
E
L
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K
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I
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L
-
L
P
L
L
V
G
C
------
V
--
K
V
--
N
I
P
---------
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Y
-----
I
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--
K
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SD-----
G
-----
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----
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----
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----------
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-------
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-----
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R
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A
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A
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-----------
M
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E
-
L
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A
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-
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A
-----
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A
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---------
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-----
T
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N
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L
L
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-----
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P
---
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-------------
L
--
D
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---
S
------
L
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D
Y
L
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L
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F
Q
S
Y
M
T
HP
V
--
Y
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R
Y
-----
T
P
--
R
L
I
------------
H
G
D
L
S
P
D
H
F
L
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N
L
N
SRQ
T
P
-
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-
I
I
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F
G
D
A
A
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P
D
Y
D
Y
V
----
Y
-
L
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E
D
-
C
G
---------------------------
E
---
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F
-------------
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Q
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Y
--
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--
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-----------
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---
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R
K
--------
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----
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L
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F
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L
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-------
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R
----
D
------
Q
D
W
-
I
S
E
G
L
E
L
L
E
E
D
K
A
--------------------------
13
HHSearch
70.66
13%
-2
- C4 -
-
5IWU
2
?
A:
[1-299]
-----
M
S
K
D
I
K
Q
V
I
E
I
A
K
K
H
N
L
F
L
------
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E
T
I
Q
F
N
E
S
G
L
-
D
F
Q
A
V
F
-
A
Q
D
N
---------
N
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L
R
L
-----
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------
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--
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I
-----
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-----------------
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K
L
D
G
-
V
-
P
A
G
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----
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---
H
NIGNYIWEID
I
-------
N
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V
P
-----
E
L
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L
G
R
V
-----------
L
A
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G
E
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L
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N
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--
M
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P
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--
G
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I
------------
H
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A
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---
A
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Y
R
A
--------------------------
F
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--
E
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L
-------------
E
A
L
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I
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A
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--
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-
G
YYW
P
-----------
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---
M
K
E
H
--------
I
----
I
--
E
L
N
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A
Y
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A
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A
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-------
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S
-
G
----
I
------
E
E
Y
-
E
Q
M
A
K
E
A
L
E
V
-----------------------------
14
HHSearch
70.06
13%
-3
- C4 -
-
5UXA
-
?
A:
[2-299]
------
S
K
D
I
K
Q
V
I
E
I
A
K
K
H
N
L
F
L
------
K
E
E
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I
Q
F
N
E
S
G
L
-
D
F
Q
A
V
F
-
A
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---------
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-----
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R
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------
A
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--
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---------
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-----
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-----------------
E
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----
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K
L
D
G
-
V
-
P
A
G
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----
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---
H
NIGNYIWEID
I
-------
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V
P
-----
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L
G
R
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-----------
L
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-----
A
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-----
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A
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-----
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-
A
---
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-----------
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--
G
E
---
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------
L
W
N
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A
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D
----
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--
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-----
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--
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------------
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A
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---
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----
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A
--------------------------
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--
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--
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-
G
YYW
P
-----------
K
---
M
K
E
H
--------
I
----
I
--
E
L
N
A
A
Y
P
V
S
I
A
E
F
A
L
-------
V
S
-
G
----
I
------
E
E
Y
-
E
Q
M
A
K
E
A
L
E
V
-----------------------------
39
Fugue
69.03
18%
20
- C4 -
-
4OCV
2
?
A:
[24-378]
---------
T
N
E
A
L
F
D
V
A
S
H
F
A
L
E
------
G
T
V
D
S
I
E
P
Y
G
D
G
H
I
N
T
T
Y
L
-
V
T
T
D
---------
G
-
P
-
R
-
Y
I
L
Q
R
MNTGI
F
P
-
D
T
---
V
----
N
L
M
R
N
V
E
L
-
V
T
S
T
L
K
A
------
Q
-
G
-
K
--
E
T
L
---------
D
I
V
R
-----
T
T
--
S
--------
G
-----
D
T
W
----
A
E
I
D
G
G
A
W
-
R
-
V
Y
K
F
IEH
T
M
S
---
Y
----------
N
-------
L
V
P
N
-----
P
D
V
F
R
E
A
G
R
A
-----------
F
G
D
-
F
Q
N
F
L
-
S
G
F
D
-----
A
N
Q
-
L
T
E
-----
T
---
I
AHFHD
T
P
H
-
R
F
E
D
F
-
K
K
A
L
A
A
D
E
-
L
-----
G
R
A
---
A
-------------
G
--
C
G
---
P
------
E
I
E
F
Y
L
S
H
A
D
Q
Y
A
V
--
V
--
M
D
G
L
R
D
GSI
P
L
--
R
V
T
------------
H
N
D
T
K
L
N
N
I
L
M
D
A
T
---
T
G
K
A
R
A
-
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
S
I
R
F
-
G
A
S
T
-
A
L
-----
E
-----------------
D
--
E
R
--
D
L
D
K
V
H
F
S
T
E
L
F
R
A
Y
T
E
G
F
-
V
G
E
L
--
R
D
S
--
I
-
T
---
A
-----------
R
---
E
A
E
L
--------
L
P
F
S
G
N
--
L
L
T
M
E
C
G
M
R
F
L
A
D
Y
L
E
GDVYFA
T
K
-
Y
----
P
------
E
H
N
-
L
V
R
S
R
T
Q
I
K
L
V
R
E
M
E
Q
R
A
D
E
T
R
A
I
V
A
D
V
M
E
T
T-------
12
HHSearch
66.88
14%
13
- C4 -
-
5IQC
2
AACA_STAAU
A:
[11-304]
--------
N
V
K
A
M
K
Y
L
I
E
H
Y
F
D
N
F
------
K
V
D
S
I
E
I
I
G
S
G
Y
-
D
S
V
A
Y
L
-
V
------------
N
-
N
-
E
-
Y
I
F
K
T
-----
K
F
-
S
T
NKK
K
----
G
Y
A
K
E
K
A
I
-
Y
N
F
L
N
T
N
------
L
E
T
N
V
--
K
I
P
---------
N
I
E
Y
-----
S
Y
--
I
S
D------
E
-----
L
S
I
----
L
G
Y
K
E
I
K
G
-
T
-
F
L
T
P
----
E
I
Y
S
T
M
----------
S
-------
E
E
E
Q
-----
N
L
L
K
R
D
I
A
S
F
-----------
L
R
Q
-
M
H
G
L
D
-
Y
T
D
I
-----
S
E
C
-
T
I
D
-----
N
-----------
K
-
Q
N
V
L
E
-
E
Y
I
L
L
R
E
T
-
I
-----
Y
-
N
---
D
-------------
L
--
T
D
---
I
------
E
K
D
Y
I
E
S
F
M
E
R
L
N
A
T-
T
--
V
F
E
G
-----
K
K
--
C
L
C
------------
H
N
D
F
S
C
N
H
L
L
L
D
G
N
---
N
R
-
L
T
G
-
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
I
----
Y
-
L
L
E
D
-
S
E
E----
E
-----------------
I
--
G
T
--
N
F
G
-------------
E
D
I
-
L
R
M
Y
--
G
N
I
--
D
-
I
---
E
-----------
K
---
A
K
E
Y
--------
Q
----
D
--
I
V
E
E
Y
Y
P
I
E
T
I
V
Y
G
I
-------
K
N
-
I
----
K
------
Q
E
F
-
I
E
N
G
R
K
E
I
Y
K
R
T
Y
K
-------------------------
11
HHSearch
64.64
14%
16
- C4 -
-
5IQI
1
AACA_STAAU
C:
[10-304]
-------
T
N
V
K
A
M
K
Y
L
I
E
H
Y
F
D
N
F
------
K
V
D
S
I
E
I
I
G
S
G
Y
-
D
S
V
A
Y
L
-
V
N
-------------
N
-
E
-
Y
I
F
K
T
-----
K
F
-
S
T
NKK
K
----
G
F
A
K
E
K
A
I
-
Y
N
F
L
N
T
N
------
L
E
T
N
V
--
K
I
P
---------
N
I
E
Y
-----
S
Y
I
S
D
--------
E
-----
L
S
I
----
L
G
Y
K
E
I
K
G
-
T
-
F
L
T
P
----
E
I
Y
S
T
M
----------
S
-------
E
E
E
Q
-----
N
L
L
K
R
D
I
A
S
F
-----------
L
R
Q
-
M
H
G
L
D
-
Y
T
D
I
-----
S
E
C
-
T
I
D
-----
N
-----------
K
-
Q
N
V
L
E
-
E
Y
I
L
L
R
E
T
-
I
-----
Y
-
N
---
D
-------------
L
--
T
D
---
I
------
E
K
D
Y
I
E
S
F
M
E
R
L
N
A
T-
T
--
V
F
E
G
-----
K
K
--
C
L
C
------------
H
N
D
F
S
C
N
H
L
L
L
D
G
N
---
N
R
-
L
T
G
-
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
I
----
Y
-
L
L
E
D
-
S
E
-----
E
E----------------
I
--
G
T
--
N
F
G
-------------
E
D
I
-
L
R
M
Y
--
G
N
I
--
D
-
I
---
E
-----------
K
---
A
K
E
Y
--------
Q
----
D
--
I
V
E
E
Y
Y
P
I
E
T
I
V
Y
G
I
-------
K
N
-
I
----
K
------
Q
E
F
-
I
E
N
G
R
K
E
I
Y
K
R
T
Y
K
-------------------------
31
Fugue
64.56
14%
-15
- C4 -
-
3I1A
2
?
A:
[3-330]
----
K
Q
P
I
Q
A
Q
Q
L
I
E
L
L
K
V
H
Y
G
I
D
------
I
H
T
A
Q
F
I
Q
G
G
A
D
T
N
A
F
A
Y
Q
-
A
D
S
E
---------
S
-
K
-
S
-
Y
F
I
K
L
-----
K
Y
-
G
----
Y
----
H
D
E
I
N
L
S
I
-
I
R
L
L
H
D
-------
S
-
G
I
K
--
E
I
I
---------
F
P
I
H
TLEAK
L
F
--
Q
--------
Q
-----
L
K
H
----
F
K
I
I
A
Y
P
F
-
I
-
H
A
P
N
----
G
F
---
T
----------
Q
-------
N
L
T
G
-----
K
Q
W
K
Q
L
-
G
K
V
-----------
L
R
Q
-
I
H
E
T
S
-
V
P
I
S
-----
I
Q
Q
-
Q
L
R
-----
K
---
E
-----
I
Y
S
-
P
K
W
R
E
-
I
V
R
S
F
Y
N
Q
-
I
EFDNS
D
-
D
---
K
-------------
L
--
T
A
---
A
------
F
K
S
F
F
N
Q
N
S
A
A
I
H
R
--
L
--
V
D
T
S
-----
E
K
--
L
S
K
K
IQPDLDKYVLC
H
S
D
I
H
A
G
N
V
L
V
G
N
E
----
E
-
S
I
Y
-
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
----
F
-
I
G
G
G
-
V
G
-----
N
-----------------
V
WN
K
P
--
H
E
I
-------------
Q
Y
F
-
Y
E
G
Y
--
G
E
I
--
N
-
V
---
D
-----------
K
---
T
I
L
S
--------
Y
----
Y
R
H
E
R
I
V
E
D
I
A
V
Y
G
Q
D
L
L
-------
S
R
N
Q
----
N
------
N
Q
S
-
R
L
E
S
F
K
Y
F
K
E
M
F
D
P
N
N
V
V
E
I
A
F
A
T
E--------------
6
HHSearch
64.06
16%
-18
- C4 -
-
5UXD
2
?
A:
[4-298]
------
P
E
D
L
D
A
L
L
D
L
A
A
R
H
G
L
D
L
------
D
G
G
T
L
R
T
E
E
I
G
L
-
D
F
R
V
A
F
-
A
R
A
H
---------
D
G
G
-
D
-
W
V
L
R
L
-----
P
R
-
R
P
DV
L
E
----
R
A
A
V
E
G
R
L
-
L
A
M
L
A
P
H
------
L
--
D
V
--
A
V
P
---------
D
W
R
I
-----
S
T
-----------------
S
E
L
----
I
A
Y
P
L
L
P
G
-
S
-
P
G
L
T
----
V
A
---
A
----------
D
G
E
V
S
W
HV
D
M
A
S
-----
T
V
Y
A
R
S
L
G
S
V
-----------
V
A
Q
-
L
H
A
V
D
-
A
E
A
A
-----
A
A
T
-
G
I
E
-----
V
---------
R
S
P
-
A
Q
V
R
G
-
A
W
R
Q
D
L
A
R
-
V
-----
G
-
A
E
F
-
E
-------------
I
--
A
P
---
A
------
L
R
E
R
W
E
A
W
L
A
D
D
G
------
C
W
P
G
-----
H
S
--
V
L
T
------------
H
G
E
L
Y
P
A
H
T
L
V
E
D
----
E
R
-
I
T
A
-
V
L
D
W
T
T
A
A
V
G
D
P
A
K
D
L
M
----
F
-
H
Q
V
S
-
A
---------------------------
P
S
--
A
I
F
-------------
E
V
A
-
L
Q
A
Y
--
A
E
G
--
G
-
G
---
R
-----------
P
W
PG
L
A
R
H
--------
C
----
T
--
E
M
F
S
A
A
P
L
G
Y
G
L
Y
A
L
-------
A
T
-
G
----
E
------
A
A
H
-
R
E
A
A
A
A
A
L
N
P
P
E
---------------------------
23
HHSearch
61.05
12%
-0
- C4 -
-
4DCA
1
?
A:
[29-316]
---------------
I
Y
E
H
L
N
K
Q
I
------
K
I
N
E
L
R
Y
L
S
S
G
D
-
D
S
D
T
F
L
-
C
------------
N
-
E
-
Q
-
Y
V
V
K
V
-----
P
K
-
R
D
S
V
R
I
----
S
Q
K
R
E
L
E
L
-
Y
R
F
L
E
N
C
------
K
-
L
S
Y
--
Q
I
P
---------
A
V
V
Y
-----
Q
S
-----------------
D
R
F
----
N
I
M
K
Y
I
K
G
-
E
-
R
I
T
Y
----
E
Q
Y
H
K
L
----------
S
-------
E
K
E
K
-----
D
A
L
A
Y
D
E
A
T
F
-----------
L
K
E
-
L
H
S
I
E
-
I
D
C
S
-----
V
S
L
-
F
S
D
A
----
L
---
V
-----
N
K
K
-
D
K
F
L
Q
-
D
K
K
L
L
I
S
I
-
L
-----
E
-
K
E
Q-
L
-------------
L
--
T
D
---
E
------
M
L
E
H
I
E
T
I
Y
E
N
I
L
S
--
N
AV
L
F
K
Y
-----
T
P
--
C
L
V
------------
H
N
D
F
S
A
N
N
M
I
F
R
N
----
N
R
-
L
F
G
-
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
----
C
-
L
L
D
C
-
S
T
D----
D
-----------------
F
--
G
K
--
E
F
G
-------------
R
K
V
-
L
K
Y
Y
--
Q
H
K
--
A
-
P
---
E
-----------
V
---
A
E
R
K
--------
A
----
E
--
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
-------
E
R
-
K
----
D
------
R
E
M
L
I
K
D
V
S
E
L
L
Q
T
Q
A
E
--------------------------
17
HHSearch
60.36
13%
-13
- C4 -
-
5IGH
-
?
A:
[8-300]
--------
D
T
S
Q
L
Y
A
L
A
A
R
-
H
G
L
K
------
L
H
G
P
L
T
V
N
E
L
G
L
-
D
Y
R
I
V
I
-
A
T
V
D
---------
D
G
R
-
R
-
W
V
L
R
I
-----
P
R
-
R
A
E
V
S
A
----
K
V
E
P
E
A
R
V
-
L
A
M
L
K
N
R
------
L
--
P
F
--
A
V
P
---------
D
W
R
V
-----
A
N
--
A
--------
E
L
V
A
--
Y
P
M
LEDS
T
A
M
V
I
Q
P
G
-
S
-
S
T
P
D
----
W
V
--------------
V
-------
P
Q
D
S
-----
E
V
F
A
E
S
F
A
T
A
-----------
L
A
A
-
L
H
A
V
P
-
I
S
A
A
-----
V
D
A
-
G
M
L
-----
I
---------
R
T
P
-
T
Q
A
R
Q
-
K
V
A
D
D
V
D
R
-
V
-----
R
-
R
---
E
-------------
F
V
V
N
D
---
K
------
R
L
H
R
W
Q
R
W
L
D
D
D
----
S
--
S
W
P
D
-----
F
S
--
V
V
V
------------
H
G
D
L
Y
V
G
H
V
L
I
D
N
T
---
E
R
-
V
S
G
-
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
----
A
-
H
L
M
V
-
F
---------------------------
G
E
--
E
G
L
-------------
A
K
L
-
L
L
T
Y
--
E
A
A
--
G
-
G
R
V
W
P
-----------
R
---
L
A
H
H
--------
I
----
A
--
E
R
L
A
F
G
A
V
T
Y
A
L
F
A
L
-------
D
S
-
G
----
N
------
E
E
Y
-
L
A
A
A
K
A
Q
L
A
A
A
----------------------------
16
HHSearch
59.63
13%
-14
- C4 -
-
5IGI
3
?
A:
[8-300]
--------
D
T
S
Q
L
Y
A
L
A
A
R
-
H
G
L
K
------
L
H
G
P
L
T
V
N
E
L
G
L
-
D
Y
R
I
V
I
-
A
T
V
D
---------
D
G
R
-
R
-
W
V
L
R
I
-----
P
R
-
R
A
E
V
S
A
----
K
V
E
P
E
A
R
V
-
L
A
M
L
K
N
R
------
L
--
P
F
--
A
V
P
---------
D
W
R
V
-----
A
N
--
A
--------
E
L
V
A
--
Y
P
M
LEDS
T
A
-
V
I
Q
P
G
-
S
-
S
T
P
D
----
W
V
--------------
V
-------
P
Q
D
S
-----
E
V
F
A
E
S
F
A
T
A
-----------
L
A
A
-
L
H
A
V
P
-
I
S
A
A
-----
V
D
A
-
G
M
L
-----
I
---------
R
T
P
-
T
Q
A
R
Q
-
K
V
A
D
D
V
D
R
-
V
-----
R
-
R
---
E
-------------
F
VV
N
D
---
K
------
R
L
H
R
W
Q
R
W
L
D
D
D
----
S
--
S
W
P
D
-----
F
S
--
V
V
V
------------
H
G
D
L
Y
V
G
H
V
L
I
D
N
T
---
E
R
-
V
S
G
-
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
----
A
-
H
L
M
V
-
F
---------------------------
G
E
--
E
G
L
-------------
A
K
L
-
L
L
T
Y
--
E
A
A
--
G
-
G
R
V
W
P
-----------
R
---
L
A
H
H
--------
I
----
A
--
E
R
L
A
F
G
A
V
T
Y
A
L
F
A
L
-------
D
S
-
G
----
N
------
E
E
Y
-
L
A
A
A
K
A
Q
L
A
A
A
----------------------------
32
Fugue
59.41
11%
-13
- C4 -
-
3HAM
3
?
A:
[1-299]
-----
M
V
N
L
D
A
E
I
Y
E
H
L
N
K
Q
I
K
I
N
------
E
L
R
Y
L
S
S
G
D
----
D
S
D
T
F
L
-
C
N
E
Q
---------
Y
-
V
-
V
-
K
V
P
K
R
-----
D
S
-
V
R
---
I
----
S
Q
K
R
E
F
E
L
-
Y
R
F
L
E
N
C
------
K
-
L
S
Y
--
Q
I
P
---------
A
V
V
Y
-----
Q
S
--
D
---------------
R
F
----
N
I
M
K
Y
I
K
G
-
E
-
R
I
T
Y
----
E
Q
---
Y
----------
H
K
LS----
E
K
E
K
-----
D
A
L
A
Y
D
E
A
T
F
-----------
L
K
E
-
L
H
S
I
E
-
I
D
C
S
-----
V
S
L
-
F
S
D
-----
A
LVN
K
-----
K
D
K
-
F
L
Q
D
K
-
K
L
L
I
S
I
L
E
-
K
-----
E
-
Q
---
L
-------------
L
--
T
D
---
E
------
M
L
E
H
I
E
T
I
Y
E
N
I
L
N
--
N
--
A
V
L
F
K
Y
---
T
P
--
C
L
V
------------
H
N
D
F
S
A
N
N
M
I
F
R
N
N
----
R
-
L
F
G
-
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
----
C
-
L
L
D
C
-
S
T
-----
D
D----------------
F
--
G
K
--
E
F
G
-------------
R
K
V
-
L
K
Y
Y
--
Q
H
K
--
A
-
P
---
E
-----------
V
---
A
E
R
K
--------
A
----
E
--
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
-------
E
R
-
K
----
D
------
R
E
M
-
L
I
K
G
V
S
E
L
L
Q
T
Q
A
E
M
F
IF---------------------
28
Fugue
58.93
16%
18
- C4 -
-
2Q83
5
COTI_BACSU
A:
[11-346]
----
L
S
A
E
D
A
K
K
L
T
E
L
A
E
N
V
L
Q
G
W
------
D
---
V
Q
A
E
K
I
D
V
I
Q
A
L
V
W
K
-
V
H
T
D
---------
S
-
G
-
A
-
V
C
L
K
R
-----
I
H
R
P
E
---
K
----
K
A
L
F
S
I
F
A
-
Q
D
Y
L
A
K
K
GMN
V
P
G
I
-
L
P
N
--
K
K
G
---------
S
L
Y
S
-----
K
H
--
G
--------
S
-----
F
L
F
----
V
V
Y
D
W
I
E
G
-
R
-
P
F
E
L
----
T
V
---
K
----------
Q
-------
D
L
E
F
I
M
K
G
L
A
D
F
H
T
A
S
V
G
Y
Q
P
P
NG
V
P
I
F
T
K
L
G
R
-
W
P
N
H
Y
-
T
K
R
C
-----
K
-
Q
M
E
T
W
-----
K
---
L
M
----
A
E
A
-
E
K
E
D
P
-
F
S
Q
L
Y
L
Q
E
-
I
-----
D
-
G
---
F
-------------
I
--
E
D
---
G
------
L
R
I
K
D
R
L
L
Q
S
T
Y
V
P
--
W
--
T
E
Q
L
-----
K
K
S
P
N
L
C
------------
H
Q
D
Y
G
T
G
N
T
L
L
G
E
N
----
E
-
Q
I
W
-
V
I
D
L
D
T
V
S
F
D
L
P
I
R
D
L
R
----
K
M
I
I
P
L
-
L
D
-----
T
-----------------
T
--
G
V
WD
D
E
T
-------------
F
N
V
M
L
N
A
Y
--
E
S
R
--
A
-
P
---
L
-----------
T
---
E
E
Q
K
Q
V
M
F
I
D
M
L
F
----
P
--
Y
E
L
Y
D
V
I
R
E
K
Y
V
R
K
S
-------
A
L
-
P
----
K
------
E
E
L
-
E
S
A
F
E
Y
E
R
I
K
A
N
A
L
R
Q
LI---------------------
25
HHSearch
58.82
14%
5
- C4 -
-
2QG7
-
?
E:
[111-450]
--------------------------------
L
E
F
Q
I
I
N
G
-
I
-
T
N
I
L
I
K
-
V
K
D
M
SK-------
Q
-
A
-
K
-
Y
L
I
R
L
-----
Y
G
-
P
K
---
T
DEII
N
R
E
R
E
K
K
I
-
S
C
I
L
Y
N
K
---------
N
I
--
A
-
K
---------
K
I
Y
V
-----
F
F
--
T
--------
N
-------
G
----
R
I
E
E
F
M
D
G
-
Y
-
A
L
S
R
----
E
D
-----------------------
I
K
N
-----
P
K
F
Q
K
L
I
A
K
N
-----------
L
K
L
-
L
H
D
I
K
-
L
N
E
N
-----
L
Y
K
-
E
L
Q
VTQKV
P
---
G
-----
T
R
P
-
S
F
L
W
N
-
T
I
W
K
Y
F
H
L
-
L
-----
N
-
E
---
E
RKKICSFDAKANI
L
--
K
L
---
I
------
D
F
D
V
L
R
D
S
I
V
E
V
E
S
L-
C
K-
R
E
N
S
-----
P
I
--
V
L
C
------------
H
C
D
L
L
S
S
N
I
I
N
T
V
G
G---
D
-
S
I
S
-
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
----
N
-
H
F
N
E
-
Y
A
-----
G
FNCDWDLT---------
P
--
S
K
--
E
E
E
-------------
Y
H
F
-
I
M
H
Y
--
L
G
T
--
D
-
D
---
E
ELIN-------
Q
---
L
I
R
E
--------
I
----
Q
--
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
-------
L
Q
-
G
MHSS
D
------
F
D
F
-
I
N
Y
G
M
T
R
L
T
A
S
C
---------------------------
26
Fugue
58.79
16%
38
- C4 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
SA
F
T
F
Q
T
L
H
P
D
T
I
M
D
A
L
F
E
H
G
I
R
V
------
D
S
G
L
T
P
L
N
S
Y
E
---
N
R
V
Y
Q
-
F
Q
D
E
---------
D
-
R
-
R
R
F
V
V
K
F
-----
Y
R
-
P
E
---
R
----
W
T
A
D
Q
I
L
E
-
E
H
Q
F
A
L
Q
------
L
-
V
N
D
--
E
V
P
VA
A
P
V
A
F
NG
Q
T
L
L
-----
N
H
--
Q
--------
G
-----
F
Y
F
----
A
V
F
P
S
V
G
G
-
R
-
Q
------------
F
----------
E
-------
A
D
N
I
-----
D
Q
M
E
A
V
G
R
Y
L
-----------
G
R
M
-
H
Q
T
G
R
-
K
Q
L
F
-----
I
H
R
-
P
T
I
-----
G
---
L
-----
N
E
Y
-
L
I
E
P
R
-
K
L
F
E
D
A
T
L
-
I
-----
P
-
S
---
G
-------------
L
--
K
A
---
A
------
F
L
K
A
T
D
E
L
I
A
A
V
T
A
H
-
W
--
R
E
D
F
-----
T
V
--
L
R
L
------------
H
G
D
C
H
A
G
N
I
L
W
R
------
D
-
G
P
M
-
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
----
M
-
L
L
N
G
-
D
K
-----
A
-----------------
E
--
Q
R
--
M
Q
L
-------------
E
T
I
-
I
E
A
Y
--
E
E
F
SE
F
-
D
---
T
-----------
A
---
E
I
G
L
--------
I
----
E
--
P
L
R
A
M
R
L
V
Y
Y
L
A
W
L
M
-------
R
R
-
W
----
A
------
D
P
A
-
F
P
K
N
F
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
EPPLQLTPMY
18
HHSearch
58.73
14%
-9
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[53-414]
---------
K
E
R
A
H
M
L
C
A
R
F
L
G
G
A
WKTVPL
E
H
L
R
I
S
R
I
K
G
G
M
-
S
N
M
L
F
L
-
C
R
L
S
EVYPPIRNE
P
-
N
-
K
-
V
L
L
R
V
-----
Y
F
-
N
P
ET
E
S
----
H
L
V
A
E
S
V
I
-
F
T
L
L
S
E
R
---------
H
L
--
G
-
P
---------
K
L
Y
G
-----
I
F
--
S
---------------
G
G
----
R
L
E
E
Y
I
P
S
-
R
-
P
L
S
C
----
H
E
-----------------------
I
S
L
-----
A
H
M
S
T
K
I
A
K
R
-----------
V
A
K
-
V
H
Q
L
E
-
V
P
I
W
-----
K
E
P
-
D
Y
L
-----
C
---------
E
A
L
-
Q
R
W
L
K
-
Q
L
T
G
T
V
D
A
-
E
-----
H
-
R
F
--
D
-------------
L
--
P
E
---
E
CGVSSV
N
C
L
D
L
A
R
E
L
E
F
L
R
A
H
-
I
S
-
L
S
K
S
-----
P
V
--
T
F
C
------------
H
N
D
L
Q
E
G
N
I
L
L
P
K
-------
R
L
V
-
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
----
N
-
H
F
I
E
-
W
T
-----
I
DYDIDEAPF
Y
K
I
Q
TENF
P
--
E
N
--
D
Q
M
-------------
L
E
F
-
F
L
N
Y
--
L
R
E
--
Q
-
G
---
N
TRENE
L
Y
K
K
S
E
D
---
L
V
Q
E
--------
T
----
L
--
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
-------
L
Q
-
V
----
E
LSPVG-
F
G
F
-
A
D
Y
G
R
D
R
L
S
L
-----------------------------
22
HHSearch
58.54
17%
-13
- C4 -
-
3DXQ
-
?
B:
[3-260]
---------
T
D
E
A
R
A
K
L
A
A
I
P
M
L
A
------
G
Y
T
G
P
L
E
R
L
G
G
L
-
T
N
L
V
F
R
-
A
--------------
G
-
D
-
L
C
L
R
I
-----
P
------------
N
R
A
N
E
A
V
A
-
A
R
E
A
A
K
A
---------
G
V
--
S
-
P
---------
E
V
L
H
-----
V
D
--
P
--------
A
-----
T
G
V
----
M
V
T
R
Y
I
A
G
-
A
Q
T
M
S
P
----
E
K
---
F
-------------------
K
T
R
-----
P
G
S
P
A
R
A
G
E
A
-----------
F
R
K
-
L
H
G
S
G
-
A
V
F
P
-----
F
R
F
-
E
-----------------------
L
F
A
-
M
I
D
D
Y
L
K
V
-
L
-----
S
-
T
KN
V
T
-------------
L
--
P
A
G
Y
H
D
------
V
V
R
E
A
G
G
V
R
S
A
L
A
------
A
H
P
L
-----
P
L
--
A
A
C
------------
H
C
D
P
L
C
E
N
F
L
D
T
G
-----
E
-
R
M
W
-
I
V
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
----
D
-
L
S
V
E
-
G
------
K
-----------------
F
--
N
A
--
N
Q
D
-------------
E
E
L
-
M
R
A
Y
--
F
G
G
--
E
A
R
---
P
-----------
A
---
E
R
G
R
--------
V
----
V
--
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
-------
I
Q
--------------------------------------------------------
20
HHSearch
54.59
17%
4
- C4 -
-
3CSV
8
?
A:
[4-250]
-------
S
R
E
D
E
I
R
D
F
L
A
T
-
H
G
Y
-------
A
D
W
N
R
T
P
---------
R
Y
Q
R
L
R
S
P
---------
T
G
A
-
K
-
A
V
L
M
D
-----
W
S
-
P
E
EG-
G
----
D
T
Q
P
F
V
D
L
-
A
Q
Y
L
R
N
L
---------
D
I
--
S
A
P
---------
E
I
Y
A
-----
E
E
--
H
--------
A
-----
R
G
L
----
L
L
I
E
D
L
G
D
-
A
-
L
F
T
E
----
V
I
---
N
----------
N
D------
P
A
Q
E
-----
M
P
L
Y
R
A
A
V
D
L
-----------
L
I
H
-
L
H
D
A
Q
-
T
P
E
L
-----
A
R
L
-
D
P
E
----------------
T
L
-
S
E
M
T
R
L
A
F
S
E
Y
R
Y
A
-
I
-----
L
-
G
---
D
-------------
A
--
A
E
---
D
------
N
R
K
R
F
E
H
R
F
A
Q
I
L
S
--
A
--
Q
L
E
G
-----
D
M
--
V
F
V
------------
H
R
D
F
H
A
Q
N
L
L
W
L
P
E
REG
L
A
-
R
V
G
-
V
I
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
V
----
S
-
L
L
Q
D
-
A
R
-----
R
D----------------
V
--
P
A
--
Q
V
E
-------------
A
Q
M
-
I
D
H
Y
--
I
Q
A
----------------------------------------------------------------------------------------------------------------------------
42
SP3
54.40
16%
12
* C4 *
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
-------
G
S
P
A
A
W
----
V
E
R
L
F
G
Y
------
D
W
A
Q
Q
T
I
G
C
---
S
D
A
A
V
F
R
-
L
S
A
Q
---------
G
-
R
P
V
-
L
F
V
K
T
-----
D
L
-
S
---------
G
A
L
N
E
L
Q
D
-
E
A
A
R
L
S
W
------
L
-
A
T
T
GV
P
C
A
---------
A
V
L
D
V
V
---
T
E
--
A
--------
G
-----
R
D
W
----
L
L
L
G
E
V
P
G
-
Q
-
D
L
L
S
----
S
H
---
L
----------
A
----------
P
-----
A
E
K
V
S
I
M
A
D
A
-----------
M
R
R
-
L
H
T
L
D
P
A
T
C
P
FDHQ
A
K
H
R
-
I
E
R
-----
A
---
R
-----
T
R
M
E
A
G
L
V
D
-
Q
D
D
L
D
E
E
H
-
Q
-----
G
----------------------
L
A
---
P
------
A
E
L
F
A
R
L
K
A
R
------
M
--
P
D
G
E
-----
D
L
--
V
V
T
------------
H
G
D
A
C
L
P
N
I
M
V
E
N
-----
G
-
R
F
S
G
F
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
----
L
-
A
T
R
D
I
A
E
-----
E
-----------------
L
--
G
G
--
E
W
A
-------------
D
R
F
-
L
V
L
Y
--
G
I
A
--
A
-
P
---
D
-----------
S
---
Q
R
I
A
--------
F
----
Y
--
R
L
L
D
E
F
F
-------------------------------------------------------------------------