@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : E1F4A0_GIAIA: (2019-01-28 )
MAVFKNNIALGKSVTEALEILERELGSQYCYCKTLEGCSNEVHIIKDVRSGLPYIMRFTRQSRFQNYSLEREILSHVVGRGVATSQAYLFADGIVAACIEGHCVESDKMLGDSPYYELIAKQMRRLHEISVQDDGTSVMYSETHYGLKSMLDISVDYIGKGREAELLYKLYSEDGVLGQLVNDHPSLLWTCISHNDLHSGNIIYSPSAQEVRFIDWEYSTYSINAFDIACFFLEFTGIDCEISAFPCASKRQDFYLYYFGSSSPPIDFLCLFFIPLACLFWAAWSSGIDGLDVYTKNRTRLGHATLRKLVNEIWPQCGLTLDKEDCELLELVDFTFQSLYTN
Atome Classification :
(20 SA)
------------------------......---...10........20-....-------.--------.--------..30....-....40.....--------...-------50-------.---....-.-.-..-60--------...-.--.....70..-.-.....80.....-..------.90-.--.------.----...-...100-....--...110........120-......-...130.-------....-.----------.---140.----------......150.......160---.--..----..------..--.--.-170.-..--...-..180-------------.----------------.---.-.-.-..--.-----190.......200-.....-----..-210.......220...-....230-...---------.---------...240-------.---------........250......--.260----------...------------.----....270.-.....---.280.-...-----.--.--.-----290---.---.--.......300.......310-..-.....320.......330.......340
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------M
A
V
FKN---NIAL
G
K
S
V
T
E
A
L
E
I
L
-
E
R
E
L-------G--------S--------Q
Y
C
Y
C
K
TL-EGCSNE
V
H
I
I
K
--------
D
V
R
-------S--------G---
L
P
Y
I
-
M
-
R
-
F
T
-
R
---------
Q
S
R
-F--QNY
S
L
E
R
E
I
-
L
-
S
H
V
VGRGVATS
Q
-
A
Y
------
L
F--A--D------
G
----
I
V
A
-
A
C
I
EGH-CVES--DKMLG-D
S
P
Y
Y
E
L
I
A
---
K
Q
M
R
R
L
-
H
E
I
SVQD-------DGT
S
-
V
----------
M
---
Y
SET----------HY
G
L
K
S
M
L
D
I
S
V
D
YIGK-----G--
R
E
----
A
E
------
L
L
--
Y
--
K
-
L
Y
-S-ED--
G
V
L
-
G
Q
L
V
--------------N----------------D---H-P-S-
L
L
--
W
-----
T
CISHNDLHSG
N
I
-
I
YSPS-----A
Q
-
E
V
R
F
I
D
W
EY
S
T
Y
S
I
N
A
-
F
D
I
A
C
F
F
-
L
E
F---------T---------GI
D
C
---------
E
---------
I
SAFPCASKRQ
D
F
Y
L
Y
Y
--FGS-----------SSP------------
P
----
I
D
F
L
C
L
F
F
-
I
P
L
A
C
---
L
F
W
A
A
-
W
SS-----G--I--D-----
G
-----
L
---
D
--
V
YTKNRTRL
G
H
A
T
L
R
K
L
V
N
E
-
I
W
-
P
QCGLTL
D
K
E
D
C
E
L
L
E
L
V
D
F
T
F
Q
S
LYTN
38
Fugue
85.19
19%
-15
- C2 -
-
2QG7
-
?
A:
[50-458]
YPITESNLRILEGED
R
S
E
K
A
K
E
L
L
K
K
Y
V
S
N
---
V
F
E
N
E
K
T
L
Y
I
Y
C
K
Y
V
-
M
L
H
Y
GKDLVNP
N
--------
E
--------
V
D
S
L
E
F
Q
I
-
I
N
G
T
N
I
L
I
K
V
K
--------
D
M
S
-------
K
--------
Q
---
A
K
Y
L
-
I
-
R
-
L
Y
G
P
---------
T
D
E
-
I
--
I
N
R
E
R
E
K
K
I
-
S
-
C
I
L
Y
N
K
N
I
A
K
K
I
-
Y
V
------
F
F
--
T
--
N
------
G
----
R
I
E
-
E
F
M
D
G
Y
-
A
L
S
R
--
E
D
-
I
K
-
N
P
K
F
Q
K
L
I
A
---
K
N
L
K
L
L
-
H
D
I
K
L
N
E
-------
N
L
Y
K
-
E
----------
L
---
Q
V
T
Q
KVPGTRPSF
L
W
N
T
I
W
K
Y
F
H
L
L
N
E
E
R
K
K
-----
I
--
C
S
----
F
D
------
A
K
--
A
--
N
-
I
L
-
K
-
L
I
D
F
D
V
L
-
R
D
S
I
--------------
V
----------------
E
---
V
-
E
-
S
-
L
C
--
K
R
E
NSP
I
V
L
C
H
C
D
L
L
S
S
N
I
-
I
N
T
V
G
-----
E
G
D
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
-
Y
D
I
A
N
H
F
-
N
E
Y
---------
A
---------
G
F
N
C
---------
D
---------
W
D
L
T
P
S
K
E
E
E
Y
H
F
I
M
H
Y
--
L
G
T
-----------
D
D
E
------------
E
L
I
N
Q
L
I
R
E
I
Q
P
F
-
Y
I
C
S
H
---
I
N
W
G
L
-
W
S
L
-----
L
Q
G
M
--
H
-----
S
-----
F
---
D
--
F
I
N
Y
G
M
T
R
L
T
A
S
C
L
P
I
F
R
S
K
-
V
------------------------------
72
HHSearch
82.29
18%
-13
- C2 -
-
3MES
3
?
A:
[51-412]
----------------------------------------
T
E
I
I
I
G
I
C
-
R
K
N
I
-------
P
--------
G
WKEINES-
Y
I
E
V
K
Q
I
F
-
S
G
L
T
N
Q
L
F
V
V
S
--------
I
V
N
----------------
E
LKH
P
R
I
L
-
F
R
I
-
Y
G
-
K
H--------
V
-
K
-
F
--
Y
D
S
K
V
E
L
D
V
-
F
-
R
Y
L
S
N
I
N
I
A
P
N
I
-
I
A
------
D
F
--
P
--
E
------
G
----
R
I
E
-
E
F
I
D
G
E
-
P
L
T
T
--
K
Q
L
Q
L
--
T
H
I
C
V
E
V
A
---
K
N
M
G
S
L
-
H
I
I
N
S
K
R
-------
A
D
F
P
-
S
----------
R
FDK
E
P
I
L
----------
F
K
R
I
Y
L
W
R
E
E
A
K
I
Q
V
S
K
-----
N
N-
I
D
----
K
E
------
L
Y
--
S
--
K
-
I
L
-------
E
E
I
-
D
Q
L
E
--------------
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
---
L
Y
S
-
P
-
A
F
--
S
-----
L
V
F
A
H
N
D
L
Q
E
N
N
L
-
L
Q
T
Q
-------
N
-
N
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
-
A
D
I
A
N
Y
F
-
C
E
Y
---------
I
---------
Y
D
Y
C
---------
S
EKQPY
F
K
F
K
Y
E
D
Y
P
C
E
E
L
R
K
L
F
I
S
V
Y
--
L
S
Q
-----------
T
L
Q
EQVMPSQ
Q
----
I
----
V
H
I
M
T
K
A
V
-
E
V
F
T
L
I
S
H
I
T
W
G
L
-
W
S
I
-----
A
------V----
E
-----
F
---
D
F
T
E
Y
A
N
T
R
F
T
H
Y
L
Q
K
K
K
E
L
I
D
Q
--------------------------------
71
HHSearch
80.24
18%
-26
- C2 -
-
3MES
2
?
B:
[51-412]
----------------------------------------
T
E
I
I
I
G
I
C
-
R
K
N
I
-------
P
--------
G
WKEINES-
Y
I
E
V
K
Q
I
F
-
S
G
L
T
N
Q
L
F
V
V
S
--------
I
V
N
----------------
E
LKH
P
R
I
L
-
F
R
I
-
Y
G
-
K
H--------
V
---
F
--
Y
D
S
K
V
E
L
D
V
-
F
-
R
Y
L
S
N
I
N
I
A
P
N
I
-
I
A
------
D
F
--
P
--
E
------
G
----
R
I
E
-
E
F
I
D
G
E
-
P
L
T
T
--
K
Q
L
Q
L
--
T
H
I
C
V
E
V
A
---
K
N
M
G
S
L
-
H
I
I
N
S
K
R
-------
A
D
F
P
-
S
----------
R
FDK
E
P
I
L
----------
F
K
R
I
Y
L
W
R
E
E
A
K
I
Q
V
S
K
-----
N
NQ
I
D
----
K
E
------
L
Y
--
S
--
K
-
I
L
-------
E
E
I
-
D
Q
L
E
--------------
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
---
L
Y
S
-
P
-
A
F
--
S
-----
L
V
F
A
H
N
D
L
Q
E
N
N
L
-
L
Q
T
Q
-------
N
-
N
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
-
A
D
I
A
N
Y
F
-
C
E
Y
---------
I
---------
Y
D
Y
C
---------
S
EKQPY
F
K
F
K
Y
E
D
Y
P
C
E
E
L
R
K
L
F
I
S
V
Y
--
L
S
Q
-----------
T
L
Q
EQVMPSQ
Q
----
I
----
V
H
I
M
T
K
A
V
-
E
V
F
T
L
I
S
H
I
T
W
G
L
-
W
S
I
-----
A
------SV---
E
-----
F
---
D
F
T
E
Y
A
N
T
R
F
T
H
Y
L
Q
K
K
K
E
L
I
D
Q
--------------------------------
74
HHSearch
79.86
19%
-22
- C2 -
-
5FUT
10
CHKA_HUMAN
A:
[10-376]
-----------------------------------------
R
R
A
Y
L
W
C
-
K
E
F
L
-------
P
GAWRGLRE
D
--------
E
F
H
I
S
V
I
R
-
G
G
L
S
N
M
L
F
Q
C
S
--------
L
P
D
-------
T
TATLGDE-
P
---
R
K
V
L
-
L
-
R
L
Y
G
--------------G
A
--
E
A
M
V
L
E
S
V
M
-
F
-
A
I
L
A
E
R
S
L
G
P
K
L
-
Y
G
------
I
F
--
P
--
Q
------
G
----
R
L
E
-
Q
F
I
P
S
R
-
R
L
D
T
--
E
E
L
S
L
--
P
D
I
S
A
E
I
A
---
E
K
M
A
T
F
-
H
G
M
K
M
P
F
-------
N
K
E
P
-----------------
K
W
L
----------
F
G
T
M
E
K
Y
L
K
E
V
L
R
I
K
F
T
-----
E
--
E
S
R
---
I
K
------
K
L
--
H
--
K
L
L
S
Y
N
-
L
P
--
L
E
L
-
E
N
L
R
--------------
S
----------------
L
---
L
-
E
S
T
-
P
S
--
P
-----
V
V
F
C
H
N
D
C
Q
E
G
N
I
-
L
L
L
E
G
RENSE
K
Q
-
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
-
F
D
I
G
N
H
F
-
C
E
W
---------
M
---------
Y
D
Y
S
YEKYPF
F
R
A
N
---------
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
--
L
P
A
-----------
F
Q
N
DFENLS
T
E
E
K
S
I
I
----
K
E
E
M
L
L
E
V
-
N
R
F
A
L
A
S
H
F
L
W
G
L
-
W
S
I
-----
V
--
Q
--
A
-----
K
ISS--
I
EF-
G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
F
H
Q
K
R
K
L
-----------------------------------
75
HHSearch
79.56
19%
-20
- C2 -
-
5FTG
11
CHKA_HUMAN
A:
[10-376]
-----------------------------------------
R
R
A
Y
L
W
C
-
K
E
F
L
-------
P
GAWRGLRE
D
--------
E
F
H
I
S
V
I
R
-
G
G
L
S
N
M
L
F
Q
C
S
--------
L
P
D
-------
T
TATLGDE-
P
---
R
K
V
L
-
L
-
R
L
Y
G
------------------
E
A
M
V
L
E
S
V
M
-
F
-
A
I
L
A
E
R
S
L
G
P
K
L
-
Y
G
------
I
F
--
P
--
Q
------
G
----
R
L
E
-
Q
F
I
P
S
R
-
R
L
D
T
--
E
E
L
S
L
--
P
D
I
S
A
E
I
A
---
E
K
M
A
T
F
-
H
G
M
K
M
P
F
-------
N
K
E
P
-----------------
K
W
L
----------
F
G
T
M
E
K
Y
L
K
E
V
L
R
I
K
F
T
-----
E
--
E
S
R
---
I
K
------
K
L
--
H
--
K
L
L
S
Y
N
-
L
P
--
L
E
L
-
E
N
L
R
--------------
S
----------------
L
---
L
-
E
S
T
-
P
S
--
P
-----
V
V
F
C
H
N
D
C
Q
E
G
N
I
-
L
L
L
E
G
RENSE
K
Q
-
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
-
F
D
I
G
N
H
F
-
C
E
W
---------
M
---------
Y
D
Y
S
YEKYPF
F
R
A
N
---------
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
--
L
P
A
-----------
F
Q
N
DFENLS
T
E
E
K
S
I
I
----
K
E
E
M
L
L
E
V
-
N
R
F
A
L
A
S
H
F
L
W
G
L
-
W
S
I
-----
V
--
Q
--
A
-----
K
ISS--
I
EF-
G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
F
H
Q
K
R
K
L
-----------------------------------
63
HHSearch
76.31
20%
-21
* C2 *
-
2QG7
-
?
D:
[110-455]
------------------------------------------------------------------------------
S
L
E
F
Q
I
I
N
-
G
G
-
T
N
I
L
I
K
V
K
--------
D
M
S
-------
K
--------
Q
---
A
K
Y
L
-
I
R
L
-
Y
G
-
P
K--------
T
D
------
N
R
E
R
E
K
K
I
-
S
-
C
I
L
Y
N
K
N
I
A
K
K
I
-
Y
V
------
F
F
--
T
--
N
------
G
----
R
I
E
-
E
F
M
D
G
Y
-
A
L
S
R
--
E
D
I
K
N
--
P
K
F
Q
K
L
I
A
---
K
N
L
K
L
L
-
H
D
I
K
L
N
E
-------
N
L
Y
K
-
E
LQVTQKVPGT
R
---
P
S
F
L
----------
W
N
T
I
W
K
Y
F
H
L
L
N
E
E
R
K
K
-----
I
--
C
S
FDAK
A
N
------
I
L
KL
I
--
D
-
F
D
-
V
-
L
R
--
D
S
I
-
V
E
V
E
--------------
S
----------------
L
---
C
-
K
R
E
-
N
S
--
P
-----
I
V
L
C
H
C
D
L
L
S
S
N
I
-
I
N
T
V
G
------
D
-
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
-
Y
D
I
A
N
H
F
-
N
E
Y
---------
A
---------
G
F
N
C
---------
D
---------
W
D
L
T
P
S
K
E
E
E
Y
H
F
I
M
H
Y
--
L
G
T
-----------
D
D
E
E-----------
L
----
I
N
Q
L
I
R
E
I
-
Q
P
F
Y
I
CSH
I
N
W
G
L
-
W
S
L
-----
L
--
Q
--
G
MHS--
S
D----
F
---
D
FI
N
Y
G
M
T
R
L
T
A
S
C
L
P
I
F
R
------------------------------------
64
HHSearch
75.35
20%
-23
- C2 -
-
2QG7
-
?
E:
[110-455]
------------------------------------------------------------------------------
S
L
E
F
Q
I
I
N
-
G
-
I
T
N
I
L
I
K
V
K
--------
D
M
S
-------
K
--------
Q
---
A
K
Y
L
-
I
R
L
-
Y
G
-
P
K--------
T
D
E
-
I
--
I
N
R
E
R
E
K
K
I
-
S
-
C
I
L
Y
N
K
N
I
A
K
K
I
-
Y
V
------
F
F
--
T
--
N
------
G
----
R
I
E
-
E
F
M
D
G
Y
-
A
L
S
R
--
E
D
I
K
N
--
P
K
F
Q
K
L
I
A
---
K
N
L
K
L
L
-
H
D
I
K
L
N
E
-------
N
L
Y
K
-
E
LQVTQKVPGT
R
---
P
S
F
L
----------
W
N
T
I
W
K
Y
F
H
L
L
N
E
E
R
K
K
-----
I
--
C
S
FDAK
A
N
------
I
L
KL
I
--
D
-
F
D
-
V
-
L
R
--
D
S
I
-
V
E
V
E
--------------
S
----------------
L
---
C
-
K
R
E
-
N
S
--
P
-----
I
V
L
C
H
C
D
L
L
S
S
N
I
-
I
N
T
V
G
G-----
D
-
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
-
Y
D
I
A
N
H
F
-
N
E
Y
---------
A
---------
G
F
N
C
---------
D
---------
W
D
L
T
P
S
K
E
E
E
Y
H
F
I
M
H
Y
--
L
G
T
-----------
D
D
E
E-----------
L
----
I
N
Q
L
I
R
E
I
-
Q
P
F
Y
I
CSH
I
N
W
G
L
-
W
S
L
-----
L
--
Q
--
G
MHS--
S
D----
F
---
D
FI
N
Y
G
M
T
R
L
T
A
S
C
L
P
I
F
R
------------------------------------
67
HHSearch
74.96
18%
-11
- C2 -
-
3C5I
3
?
D:
[14-366]
----------------------------------------
P
L
Y
I
K
K
I
C
-
L
E
K
V
-------
P
EWNHFTE-
D
--------
N
L
R
V
K
Q
I
L
---
L
T
N
Q
L
F
E
V
G
--------
L
K
E
-------
E
T
A
N
N
Y
NSI
R
---
T
R
V
L
-
F
R
I
-
Y
G
-
K
H--------
V
D
E
-
L
--
Y
N
T
I
S
E
F
E
V
-
Y
-
K
T
M
S
K
Y
K
I
A
P
Q
L
-
L
N
------
T
F
--
N
--
G
------
G
----
R
I
E
-
E
W
L
Y
G
D
-
P
L
R
I
--
D
D
L
K
N
--
P
T
I
L
I
G
I
A
---
N
V
L
G
K
F
-
H
T
L
S
R
K
R
-------
H
L
P
E
-
H
WD--------
R
---
T
P
C
I
----------
F
K
M
M
E
K
W
K
N
Q
L
F
K
Y
K
N
I
-----
E
--
K
Y
----
N
C
------
D
I
--
H
--
K
-
Y
I
-
K
E
S
D
--
K
F
I
-
K
F
M
K
--------------
V
----------------
Y
S
KS
D
-
N
-
L
-
A
N
--
T
-----
I
V
F
C
H
N
D
L
Q
E
N
N
I
-
I
N
T
N
-------
K
-
C
L
R
L
I
D
F
E
Y
S
G
F
N
F
L
A
-
T
D
I
A
N
F
F
-
I
E
T
---------
S
---------
I
D
Y
S
---------
V
SSYPF
F
E
I
D
K
K
K
Y
I
S
Y
E
N
R
K
L
F
I
T
A
Y
--
L
S
N
-----------
Y
L
D
KVVPT
P
K
-----
L
----
I
D
E
I
L
E
A
V
-
E
V
Q
A
L
G
A
H
L
L
W
G
F
-
W
S
I
-----
I
--
R
--
G
Y
Q---
T
KSYNE
F
---
D
F
F
L
Y
A
E
Q
R
L
K
M
Y
D
D
Q
K
E
Y
L
I
S
N
-
N
I
-
I
K
--------------------------
65
HHSearch
71.29
20%
-28
- C2 -
-
1NW1
-
CKA2_CAEEL
A:
[55-425]
------------------------------------------
R
A
H
M
L
C
-
A
R
F
L
-------
G
--------
G
AWKTVPLE
H
L
R
I
S
R
I
K
-
G
G
M
S
N
M
L
F
L
C
R
--------
L
S
E
VYPPIRN
E
--------
P
---
N
K
V
L
-
L
R
V
-
Y
F
-
N
---------
P
E
T
-
E
--
S
H
L
V
A
E
S
V
I
-
F
-
T
L
L
S
E
R
H
L
G
P
K
L
-
Y
G
------
I
F
--
S
--
G
------
G
----
R
L
E
-
E
Y
I
P
S
R
-
P
L
S
C
--
H
E
I
S
L
--
A
H
M
S
T
K
I
A
---
K
R
V
A
K
V
-
H
Q
L
E
V
P
I
-------
W
K
E
P
-----------------
D
Y
L
----------
C
E
A
L
Q
R
W
L
K
Q
L
T
G
T
V
D
A
E
H
R
F
D
L
--
P
E
----
E
C
------
G
V
--
S
SV
N
-
C
L
-
D
-
L
A
--
R
E
L
-
E
F
L
R
--------------
A
----------------
H
---
I
-
S
L
S
-
K
S
--
P
-----
V
T
F
C
H
N
D
L
Q
E
G
N
I
-
L
L
P
K
---------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
-
F
D
F
A
N
H
F
-
I
E
W
---------
T
---------
I
D
Y
D
IDEAPF
Y
K
I
Q
---------
T
E
N
F
P
E
N
D
Q
M
L
E
F
F
L
N
Y
--
L
R
E
-----------
Q
G
N
TRENE
L
Y
K
----
K
----
S
E
D
L
V
Q
E
T
-
L
P
F
V
P
V
S
H
F
F
W
G
V
-
W
G
L
-----
L
--
Q
--
V
ELSPV
G
-----
F
---
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
--------------------------------
66
HHSearch
69.90
20%
-28
- C2 -
-
1NW1
-
CKA2_CAEEL
B:
[55-425]
------------------------------------------
R
A
H
M
L
C
-
A
R
F
L
-------
G
--------
G
AWKTVPLE
H
L
R
I
S
R
I
K
-
G
G
M
S
N
M
L
F
L
C
R
--------
L
S
E
VYPPIRN
E
--------
P
---
N
K
V
L
-
L
R
V
-
Y
F
-
N
---------
P
E
T
-
E
--
S
H
L
V
A
E
S
V
I
-
F
-
T
L
L
S
E
R
H
L
G
P
K
L
-
Y
G
------
I
F
--
S
--
G
------
G
----
R
L
E
-
E
Y
I
P
S
R
-
P
L
S
C
--
H
E
I
S
L
--
A
H
M
S
T
K
I
A
---
K
R
V
A
K
V
-
H
Q
L
E
V
P
I
-------
W
K
E
P
-----------------
D
Y
L
----------
C
E
A
L
Q
R
W
L
K
Q
L
T
G
T
V
D
A
E
H
R
F
D
L
--
P
E
----
E
C
------
G
V
--
S
SV
N
-
C
L
-
D
-
L
A
--
R
E
L
-
E
F
L
R
--------------
A
----------------
H
---
I
-
S
L
S
-
K
S
--
P
-----
V
T
F
C
H
N
D
L
Q
E
G
N
I
-
L
L
P
K
---------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
-
F
D
F
A
N
H
F
-
I
E
W
---------
T
---------
I
D
Y
D
IDEAPF
Y
K
I
Q
---------
T
E
N
F
P
E
N
D
Q
M
L
E
F
F
L
N
Y
--
L
R
E
-----------
Q
G
N
TRENE
L
Y
K
----
K
----
S
E
D
L
V
Q
E
T
-
L
P
F
V
P
V
S
H
F
F
W
G
V
-
W
G
L
-----
L
--
Q
--
V
ELSPV
G
-----
F
---
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
--------------------------------
40
Fugue
63.61
17%
-5
- C2 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
------------G
M
K
E
L
L
S
T
MDLD
T
D
A
N
T
I
---
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
-
G
G
A
W
-------
K
TVPL----
E
--------
H
L
R
I
S
R
I
K
-
G
G
M
S
N
M
L
F
L
C
R
L
S
EVYPPI
R
N
E
-------
P
--------
N
---
K
V
L
L
-
R
-
V
-
Y
F
-
N
---------
P
E
T
-
E
--
S
H
L
V
A
E
S
V
I
-
F
-
T
L
L
S
E
R
H
L
G
P
K
L
-
Y
G
------
I
F
--
S
--
G
------
G
----
R
L
E
-
E
Y
I
P
S
R
-
P
L
S
C
--
H
E
I
S
--
L
A
H
M
S
T
K
I
A
---
K
R
V
A
K
V
-
H
Q
L
E
V
P
I
-------
W
K
E
P
-
D
----------
Y
---
L
C
E
A
----------
L
Q
R
W
L
K
Q
L
T
G
T
V
D
A
E
H
R
-----
F
--
D
L
----
P
E
------
E
C
--
G
--
V
-
S
S
-
V
-
N
C
--
L
D
L
-
A
R
E
L
--------------
E
----------------
F
---
L
-
R
-
A
-
H
I
--
S
L
SKSP
V
T
F
C
H
N
D
L
Q
E
G
N
I
-
L
L
P
K
---------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
-
F
D
F
A
N
H
F
-
I
E
W
T
IDYDIDEA
P
---------
F
Y
K
I
---------
Q
---------
T
E
N
F
P
E
N
D
Q
M
L
E
F
F
L
N
Y
--
L
R
E
Q
GNTRENE
L
Y
K
K
S
E
------------
D
----
L
V
Q
E
T
L
P
F
-
V
P
V
S
H
---
F
F
W
G
V
-
W
G
L
-----
L
--
Q
--
V
-----
E
-----
L
---
S
--
P
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
------------
K
Q
L
L
K
N
L
A
------------
44
Fugue
63.49
15%
-97
- C2 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
-------------------------
A
K
M
R
I
---
S
P
E
L
K
K
L
I
E
K
Y
-
R
C
V
-
K
D
T
E
-------
G
--------
M
--------
S
P
A
K
V
Y
K
L
-
V
G
E
N
E
N
L
Y
L
K
M
--------
T
D
S
-------
R
--------
Y
---
K
G
T
T
-
Y
-
D
-
V
E
-
R
---------
E
K
D
-
M
--
M
L
W
L
E
G
K
L
P
-
V
-
P
K
V
L
H
F
E
R
H
D
G
W
-
S
N
------
L
L
--
M
--
S
------
E
----
A
D
G
-
V
L
C
S
E
E
-
Y
E
D
E
--
Q
S
----
P
E
K
I
I
E
L
Y
A
---
E
C
I
R
L
F
-
H
S
I
D
I
S
D
-------
C
P
Y
T
-
N
----------
S
---
L
D
S
R
----------
L
A
E
L
D
Y
L
L
N
--
N
D
L
A
D
V
-----
D
--
C
E
----
N
W
------
E
E
--
D
--
T
-
P
F
-
K
-
D
P
--
R
E
L
-
Y
D
F
L
--------------
K
----------------
T
---
E
-
K
-
P
-
E
E
--
E
-----
L
V
F
S
H
G
D
L
G
D
S
N
I
-
F
V
K
D
G
------
K
-
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
-
Y
D
I
A
F
C
V
-
R
S
I
---------
R
---------
E
D
I
G
---------
E
------------------------------------------------------------------------------------------------------------------------------------
E
Q
Y
V
E
L
-
F
F
-
D
L
L
G
I
K
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
------
53
SP3
62.93
17%
-5
- C2 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
----------------G
M
K
E
L
L
S
T
M
D
L
D
T
D
ANT
I
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
G
A
W
-------
K
TVPL----
E
--------
H
L
R
I
S
R
I
K
-
G
G
M
S
N
M
L
F
L
C
R
--------
L
S
E
VYPPIRN
E
--------
P
---
N
K
V
L
-
L
-
R
-
V
Y
F
N
---------
P
E
T
-
E
--
S
H
L
V
A
E
S
V
I
-
F
-
T
L
L
S
E
R
H
L
G
P
K
L
-
Y
G
------
I
F
--
S
--
G
------
G
----
R
L
E
-
E
Y
I
P
S
R
-
P
L
S
C
--
H
E
I
-
S
-
L
A
H
M
S
T
K
I
A
---
K
R
V
A
K
V
-
H
Q
L
E
V
P
I
-------
W
K
E
P
D
Y
----------
L
---
C
E
A
L
----------
Q
R
W
L
K
Q
L
T
G
T
V
D
A
E
H
R
F
-----
D
--
L
P
----
E
E
CGVSSV
N
C
--
L
--
D
-
L
A
-
R
-
E
L
--
E
F
L
-
R
A
H
I
--------------
S
----------------
L
---
S
-
K
-
S
-
P
---------
V
T
F
C
H
N
D
L
Q
E
G
N
I
-
L
L
P
K
R
---------
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
-
F
D
F
A
N
H
F
-
I
E
W
---------
T
IDYDIDEAP
F
Y
K
I
---------
Q
---------
T
E
N
F
P
E
N
D
Q
M
L
E
F
F
L
N
Y
--
L
R
E
-----------
Q
G
N
TRENE
L
Y
K
K
S
E
-
D
----
L
V
Q
E
T
L
P
F
-
V
P
V
S
H
---
F
F
W
G
V
-
W
G
L
L
Q
V
EL
S
--
P
--
V
-----
G
-----
F
---
G
--
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
--------
Q
L
L
K
N
L
A
---------------------
70
HHSearch
61.53
20%
16
- C2 -
-
4R7B
-
?
A:
[29-304]
--------------------------------------------
I
S
S
L
-
L
S
Q
E
-------
E
--------
E
--------
V
L
S
V
E
Q
L
--
G
G
M
T
N
Q
N
Y
L
A
K
--------
T
T
N
--------------------
K
Q
Y
I
-
V
K
F
-
F
G
-
K
G--------
T
E
K
-
L
--
I
N
R
Q
D
E
K
Y
N
-
L
-
E
L
L
K
D
L
G
L
D
V
K
N
-
Y
L
------
F
D
IE
A
--
G
------
I
----
K
V
N
-
E
Y
I
E
S
A
I
T
L
D
S
--
T
S
--
I
--
K
T
K
F
D
K
I
A
---
P
I
L
Q
T
I
-
H
T
S
A
K
E
L
-------
R
G
E
------------------
F
A
P
----------
F
E
E
I
K
K
Y
E
S
L
I
E
E
Q
I
P
Y
---------------
A
------
N
Y
--
E
--
S
-
V
-----
R
--
N
A
V
-
F
S
L
E
--------------
K
----------------
R
---
L
-
A
-
D
L
G
V
--
D
-----
R
K
S
C
H
I
D
L
V
P
E
N
F
-
I
E
S
P
------
Q
G
-
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
-
W
D
L
A
A
L
F
-
L
E
S
---------
E
------------------------------------
F
T
S
Q
E
E
E
T
F
L
S
H
Y
--
E
S
D
-----------
Q
T
P
-------------------
V
S
H
E
K
I
-
A
I
Y
K
I
L
Q
D
T
I
W
S
L
-
W
T
V
-----
Y
--
K
--
E
E
Q
---
G
-----
E
---
D
FG
D
Y
G
V
N
R
Y
Q
R
A
V
K
G
L
A
S
Y
G
----------------------------------
69
HHSearch
60.37
20%
18
- C2 -
-
4R78
2
?
A:
[29-304]
--------------------------------------------
I
S
S
L
-
L
S
Q
E
-------
E
--------
E
--------
V
L
S
V
E
Q
L
--
G
G
M
T
N
Q
N
Y
L
A
K
--------
T
T
N
--------------------
K
Q
Y
I
-
V
K
F
-
F
G
-
K
G--------
T
E
K
-
L
--
I
N
R
Q
D
E
K
Y
N
-
L
-
E
L
L
K
D
L
G
L
D
V
K
N
-
Y
L
------
F
D
IE
A
--
G
------
I
----
K
V
N
-
E
Y
I
E
S
A
I
T
L
D
S
--
T
S
--
I
--
K
T
K
F
D
K
I
A
---
P
I
L
Q
T
I
-
H
T
S
A
K
E
L
-------
R
G
E
------------------
F
A
P
----------
F
E
E
I
K
K
Y
E
S
L
I
E
E
Q
I
P
Y
---------------
A
------
N
Y
--
E
--
S
-
V
-----
R
--
N
A
V
-
F
S
L
E
--------------
K
----------------
R
---
L
-
A
-
D
L
G
V
--
D
-----
R
K
S
C
H
I
D
L
V
P
E
N
F
-
I
E
S
P
------
Q
G
-
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
-
W
D
L
A
A
L
F
-
L
E
S
---------
E
------------------------------------
F
T
S
Q
E
E
E
T
F
L
S
H
Y
--
E
S
D
-----------
Q
T
P
-------------------
V
S
H
E
K
I
-
A
I
Y
K
I
L
Q
D
T
I
W
S
L
-
W
T
V
-----
Y
--
K
--
E
E
Q
---
G
-----
E
---
D
FG
D
Y
G
V
N
R
Y
Q
R
A
V
K
G
L
A
S
Y
G
----------------------------------
41
Fugue
60.33
12%
-25
- C2 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
----------------------------
S
A
---
F
T
F
Q
T
L
H
P
D
T
I
M
D
A
L
-
F
E
H
G
-------
I
--------
R
--------
V
D
S
G
L
T
P
L
-
N
S
Y
E
N
R
V
Y
Q
F
---------
Q
D
E
-------
D
--------
R
---
R
R
F
V
-
V
-
K
-
F
Y
-
R
---------
P
E
R
-
W
T
A
D
Q
I
L
E
E
H
Q
F
-
A
-
L
Q
L
V
N
D
E
V
P
V
A
A
-
P
V
A
F
NGQT
L
L
--
N
--
H
------
Q
----
G
F
Y
-
F
A
V
F
P
S
-
V
G
G
R
--
Q
F
E
A
D
-
N
I
D
Q
M
E
A
V
G
---
R
Y
L
G
R
M
-
H
Q
T
G
R
K
Q
LF-----
I
H
R
P
-
T
----------
I
---
G
L
N
E
----------
Y
L
I
E
P
R
K
L
F
E
D
A
T
L
I
P
S
-----
G
--
L
K
----
A
A
------
F
L
--
K
--
A
-
T
D
-
E
-
L
I
--
A
A
V
-
T
A
H
W
--------------
R
----------------
E
---
D
-
F
-
T
-----------
V
L
R
L
H
G
D
C
H
A
G
N
I
-
L
W
R
D
---------
G
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
-
Q
D
L
W
M
L
L
-
N
G
D
--------------------------------------------
K
A
E
Q
R
M
Q
L
E
T
I
I
E
A
Y
E
E
F
S
E
-----------
F
D
T
------------
A
----
E
I
G
L
I
E
P
L
-
R
A
M
R
L
---
V
Y
Y
L
A
-
W
L
M
-----
R
--
R
--
W
-----
A
-----
D
---
P
--
A
F
P
K
N
F
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
-
T
F
-
I
E
Q
A
K
V
L
Q
E
P
P
L
Q
L
T
P
M
Y
----------
47
Fugue
59.06
17%
-1
- C2 -
-
3DXP
1
?
A:
[20-359]
--------------------------------------
R
F
D
T
E
A
L
E
A
W
M
R
Q
H
V
-------
E
GF------
A
--------
G
P
L
S
V
E
Q
F
-
K
G
Q
S
N
P
T
F
K
L
V
----------
T
-------
P
--------
G
---
Q
T
Y
V
M
R
-
A
---------------------
K
P
G
A
I
E
R
E
Y
R
V
M
D
A
L
A
G
T
D
V
P
V
A
K
M
Y
A
------
L
C
--
E
--
D
ESVIG
R
A
----
F
Y
I
M
E
F
V
S
G
R
-
V
L
W
D
--
Q
S
L
P
G
M
S
P
A
E
R
T
A
I
Y
D
E
M
N
R
V
I
A
A
M
H
T
V
D
Y
Q
A
-------
I
G
L
G
-
D
----------
Y
---
G
K
P
G
----------
N
Y
F
Q
R
Q
I
E
R
W
T
K
Q
Y
K
L
S
-----
E
--
T
E
----
S
-------------------
I
-
P
A
M
-
D
S
L
M
D
W
L
P
--------------
Q
----------------
H
---
I
-
P
-
Q
-
E
D
AD
L
-----
T
S
I
V
H
G
D
Y
R
L
D
N
L
M
F
H
P
T
E
-----
P
R
-
V
L
A
V
L
D
W
E
L
S
T
L
G
-
H
P
M
G
D
F
G
Y
H
C
M
S
W
H
---------
I
APGQFRGIA
G
L
D
H
---------
A
---------
A
L
G
I
P
D
E
A
S
Y
R
K
L
Y
E
Q
R
--
T
G
R
-----------
P
I
T
------------
G
D---
W
N
F
Y
L
A
F
S
M
F
R
I
A
G
---
I
L
Q
G
I
M
K
R
V
-------------------------------
V
D
G
T
A
S
S
A
Q
A
L
D
A
G
K
R
A
R
P
M
A
E
M
G
W
E
Y
A
K
K
A
K
Q
------------------
12
PsiBlast_PDB
58.01
18%
-26
- C2 -
-
3MES
3
?
A:
[66-350]
--------------------------------------------------
K
E
I
-------
N
--------
E
--------
S
Y
I
E
V
K
Q
I
F
S
G
L
T
N
Q
L
F
V
V
S
--------
I
V
N
-------
E
-----------------
L
-
K
-
H
P
-
R
I
L
F
R
I
Y
G
KH
V
-
K
-
F
--
Y
D
S
K
V
E
L
D
V
-
F
-
R
Y
L
S
N
I
N
I
A
P
N
I
-
I
A
------
D
F
--
P
--
E
------
G
----
R
I
E
-
E
F
I
D
G
E
-
P
L
T
T
--
K
Q
L
Q
L
-
T
H
I
C
V
E
-
V
A
---
K
N
M
G
S
L
-
H
I
I
N
S
K
R
ADFPSRF
D
K
E
P
-
I
----------
L
---
F
K
R
I
-----------
Y
L
W
R
E
E
A
K
I
Q
V
S
K
N
N
---------
I
D
----
K
E
------
L
Y
--
S
--
K
-
I
L
-
E
-
E
I
--
D
Q
L
-
E
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
----------------
L
---
Y
-
S
-
P
-
A
F
--
S
-----
L
V
F
A
H
N
D
L
Q
E
N
N
L
-
L
--
Q
T
-----
Q
N
-
N
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
-
A
D
I
A
N
Y
F
-
C
E
Y
---------
I
---------
Y
D
Y
C
SEKQPY
F
K
F
K
---------
Y
E
D
Y
P
C
E
E
L
R
K
L
F
I
S
V
Y
--
L
S
Q
-----------
T
-------------------------------------------------------------------------------------------------------------------------------
76
HHSearch
57.47
16%
-50
- C2 -
-
3DXQ
-
?
B:
[21-286]
--------------------------------------------------------------------------------
G
P
L
E
R
L
-
G
G
L
T
N
L
V
F
R
A
--------------------------------
G
D
L
C
-
L
R
I
-
P
--------------------
N
R
A
N
E
A
V
A
-
A
-
R
E
A
A
K
A
G
V
S
P
E
V
-
L
H
------
V
D
--
P
AT
G
------
V
----
M
V
T
-
R
Y
I
A
G
A
Q
T
M
S
P
--
E
K
F
K
T
-
R
P
G
S
P
A
R
A
G
---
E
A
F
R
K
L
-
H
G
S
G
A
V
F
-------
P
F
R
------------------
F
E
L
----------
F
A
M
I
D
D
Y
L
K
V
L
S
T
K
N
V
T
-----
L
--
P
------
A
------
G
Y
--
H
--
D
-
V
-----
V
--
R
E
A
-
G
G
V
R
--------------
S
----------------
A
---
L
-
A
A
H
-
P
L
--
P
-----
L
A
A
C
H
C
D
P
L
C
E
N
F
-
L
D
T
G
-------
E
-
R
M
W
I
V
D
W
E
Y
S
G
M
N
D
P
L
-
W
D
L
G
D
L
S
-
V
E
G
---------
K
------------------------------------
F
N
A
N
Q
D
E
E
L
M
R
A
Y
--
F
G
G
-----------
E
A
R
------------------
P
A
E
R
G
R
V
-
V
I
Y
K
A
M
C
D
L
L
W
T
L
-
W
G
L
-----
I
--
Q
L
A
N
-----
D
-----
N
PVD
D
F
R
A
Y
A
D
G
R
F
A
R
C
K
A
L
M
E
-------------------------------------
55
SP3
57.43
11%
-3
- C2 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
---------------------------------------
A
K
M
R
I
S
P
E
L
-
K
K
L
I
-------
E
-----------------
K
Y
R
C
V
K
D
T
-
E
G
M
S
P
A
K
V
Y
K
L
--------
V
G
E
-------
N
--------
E
---
N
L
Y
L
-
K
-
M
-
T
D
-
S
RY-------
K
G
T
-
T
--
Y
D
V
E
R
E
K
D
M
-
M
-
L
W
L
E
G
K
L
P
V
P
K
V
-
L
H
------
F
E
--
R
--
H
------
D
G
W
S
N
L
L
M
-
S
E
A
D
G
V
-
L
C
S
E
E
Y
E
D
E
Q
S
-
P
E
K
I
I
E
L
Y
A
---
E
C
I
R
L
F
-
H
S
I
D
I
S
D
-------
C
P
Y
T
-
N
----------
S
---
L
D
S
R
----------
L
A
E
L
D
Y
L
L
N
--
N
D
L
A
D
V
-----
D
--
C
E
----
N
W
------
E
E
--
D
--
T
-
P
F
-
K
-
D
P
--
R
E
L
-
Y
D
F
L
--------------
K
----------------
T
---
E
-
K
-
P
-
E
E
--
E
-----
L
V
F
S
H
G
D
L
G
D
S
N
I
-
F
V
K
D
------
G
K
-
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
-
Y
D
I
A
F
C
V
-
R
S
I
------------------------------------------
R
E
D
I
G
E
E
Q
Y
V
E
L
F
F
D
L
L
----------------
G
I
K
------------
P
----
D
W
E
K
I
K
Y
Y
-
I
L
L
D
E
---
L
F
-----------------------------------------------------------------------------------------