@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : E9F776_METRA: (2019-01-28 )
MSAANPPRPSRSLQGKVAIVTGAGSRGETIGNGRAIALLLAEDGAKVVCVDREEALAQRTAELVLAENEGASALAVAADVSSAEECARVVDAALRLFGRVDVLVNGVGVLGPPGTAVDVDAARWARGLEVNVTSMMLMAKYAVPAMRDNEPEAGVRGSIVNLGSVAGLRGGTPSLLYPTSKCAVVNMTRAMAAHHAKDGVRVNCVCPGMLYTPMVYDAEGGMSAEVREARRRRSLLQTEGNAWDCAGPVRFLAGGEARWITGTVLTVDAGATCALAVSMPDGE
Atome Classification :
(71 SA)
.........10--........20........30........40......-..50--------------.-.......60.------.......70....-....80........90........100.......110--.......-.120-.......130......-.140.......150.......160....---...-170...-.--...180.......190.......200..--.....210..-------.-----..--..220.....-..230.....----....---------240..-.......250.......260.......270.......280.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSAANPPRPSR--SLQG
K
V
A
I
V
TGAGSRGETIGNG
R
A
I
A
L
L
L
AEDG
A
K
V
-
V
C
VD--------------
R
-
E
E
A
L
A
Q
R
T
A
E
------
L
V
L
AENEGA
S
A
L
A
-
V
AADVS
S
A
E
E
C
A
R
V
V
D
A
A
L
R
L
F
G
R
V
D
V
L
VNGVGVLG---PPG
T
A
VD-V
D
A
A
-
R
WARGL
E
V
N
V
T
S
M
M
L
M
-
A
K
YAVPAMRDNEPEAGVRG
S
I
V
NLGSVA---GLR-GGTPS
L
-
L
--YPTS
K
C
A
V
V
N
M
T
R
A
M
A
A
HHAKD
G
V
R
V
N
C
--VCPGM
L
Y
T
P
M
-------
V
-----YD--AEGGM
S
A
E
V
R
-
E
A
R
--
R
R
R
S
L
----
L
QTE---------G--NA-WDCAGP
V
R
F
LAGGE
A
R
W
I
T
G
T
V
L
T
VDAG
A
T
C
A
L
A
V
SMPDGE
21
Blastp_CBE
84.52
42%
-99
- C7 -
-
5JC8
4
?
D:
[15-270]
--------------
L
Q
G
K
V
A
L
V
T
G
A
G
C
I
G
P
G
W
G
N
G
R
A
I
A
V
R
F
A
E
E
G
A
H
V
-
I
A
V
D
--------------
R
-
D
L
A
S
M
D
A
T
L
E
------
L
V
R
A
--
A
G
G
S
V
T
P
-
C
L
C
D
V
T
D
S
A
S
V
E
R
L
V
A
D
S
V
A
R
C
G
R
V
D
I
L
V
N
N
V
G
A
-
P
---
S
P
G
G
P
V
A
-
L
D
E
A
-
Q
W
A
M
Q
L
E
L
N
L
T
T
A
F
L
M
-
C
K
Y
V
L
P
V
M
---
E
Q
Q
G
G
--
G
A
I
V
N
I
A
S
T
S
---
G
I
R
W
T
G
A
A
Q
V
-
G
--
Y
A
A
A
K
A
G
M
I
Q
M
G
R
V
V
A
V
E
Y
A
A
K
N
V
R
V
N
S
--
V
V
P
G
L
L
H
T
P
M
-------
V
DTKIA
H
N
-----
G
D
V
E
L
L
L
-
R
K
R
--
Q
A
R
I
P
----
M
P
F
M
---------
G
--
D
G
-
R
D
T
A
N
A
A
L
F
L
A
S
D
E
A
R
F
V
T
G
T
E
I
V
V
D
G
G
-------------
2
PsiBlast_PDB
83.39
37%
-83
- C7 -
-
4DQX
-
?
A:
[22-271]
---------
S
M
--
D
L
N
Q
R
V
C
I
V
T
G
G
G
S
-----
G
I
G
R
A
T
A
E
L
F
A
K
N
G
A
Y
V
-
V
V
A
D
--------------
V
-
N
E
D
A
A
V
R
V
A
N
------
E
I
-----
G
S
K
A
F
G
-
V
R
V
D
V
S
S
A
K
D
A
E
S
M
V
E
K
T
T
A
K
W
G
R
V
D
V
L
V
N
N
A
G
-
F
G
---
T
T
G
N
V
V
T
-
I
P
E
E
-
T
W
D
R
I
M
S
V
N
V
K
G
I
F
L
C
-
S
K
Y
V
I
P
V
M
R
R
N
G
G
-----
G
S
I
I
N
T
T
S
Y
T
---
A
T
S
-
A
I
A
D
R
T
-
A
--
Y
V
A
S
K
G
A
I
S
S
L
T
R
A
M
A
M
D
H
A
K
E
G
I
R
V
N
A
--
V
A
P
G
T
I
D
S
P
Y
-------
F
-----
T
K
I
F
A
E
A
K
D
P
A
K
L
R
-
S
D
F
--
N
A
R
A
V
----
M
D
R
M
---------
G
--
T
A
-
E
E
I
A
E
A
M
L
F
L
A
S
D
R
S
R
F
A
T
G
S
I
L
T
V
D
G
G
S
S
I
----------
249
Blastp_CBE
83.16
32%
0
- C- -
-
1GEG
2
BUDC_KLEPN
A:
[3-252]
-----------------
K
V
A
L
V
T
G
A
G
Q
-----
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
-
A
I
A
D
--------------
Y
-
N
D
A
T
A
K
A
V
A
S
------
E
I
--
N
Q
A
G
G
H
A
V
A
-
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
V
-----
A
P
S
T
P
I
E
S
I
T
P
E
-
I
V
D
K
V
Y
N
I
N
V
K
G
V
I
W
G
-
I
Q
A
A
V
E
A
F
K
----
K
E
G
H
G
G
K
I
I
N
A
C
S
Q
A
---
G
H
V
-
G
N
P
E
L
A
-
V
--
Y
S
S
S
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
--
Y
C
P
G
I
V
K
T
P
M
W
A
E
I
D
R
Q
V
-----
S
E
--
A
A
G
K
P
L
G
Y
G
T
-
A
E
F
--
A
K
R
I
T
----
L
G
R
L
---------
S
--
E
P
-
E
D
V
A
A
C
V
S
Y
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
-------------
248
Blastp_CBE
83.16
32%
0
- C- -
-
1GEG
2
BUDC_KLEPN
B:
[3-252]
-----------------
K
V
A
L
V
T
G
A
G
Q
-----
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
-
A
I
A
D
--------------
Y
-
N
D
A
T
A
K
A
V
A
S
------
E
I
--
N
Q
A
G
G
H
A
V
A
-
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
V
-----
A
P
S
T
P
I
E
S
I
T
P
E
-
I
V
D
K
V
Y
N
I
N
V
K
G
V
I
W
G
-
I
Q
A
A
V
E
A
F
K
----
K
E
G
H
G
G
K
I
I
N
A
C
S
Q
A
---
G
H
V
-
G
N
P
E
L
A
-
V
--
Y
S
S
S
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
--
Y
C
P
G
I
V
K
T
P
M
W
A
E
I
D
R
Q
V
-----
S
E
--
A
A
G
K
P
L
G
Y
G
T
-
A
E
F
--
A
K
R
I
T
----
L
G
R
L
---------
S
--
E
P
-
E
D
V
A
A
C
V
S
Y
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
-------------
247
Blastp_CBE
83.16
32%
0
- C- -
-
1GEG
2
BUDC_KLEPN
C:
[3-252]
-----------------
K
V
A
L
V
T
G
A
G
Q
-----
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
-
A
I
A
D
--------------
Y
-
N
D
A
T
A
K
A
V
A
S
------
E
I
--
N
Q
A
G
G
H
A
V
A
-
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
V
-----
A
P
S
T
P
I
E
S
I
T
P
E
-
I
V
D
K
V
Y
N
I
N
V
K
G
V
I
W
G
-
I
Q
A
A
V
E
A
F
K
----
K
E
G
H
G
G
K
I
I
N
A
C
S
Q
A
---
G
H
V
-
G
N
P
E
L
A
-
V
--
Y
S
S
S
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
--
Y
C
P
G
I
V
K
T
P
M
WAEIDRQ
V
-----
S
E
--
A
A
G
K
P
L
G
Y
G
T
-
A
E
F
--
A
K
R
I
T
----
L
G
R
L
---------
S
--
E
P
-
E
D
V
A
A
C
V
S
Y
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
-------------
246
Blastp_CBE
83.16
32%
0
- C- -
-
1GEG
2
BUDC_KLEPN
D:
[3-252]
-----------------
K
V
A
L
V
T
G
A
G
Q
-----
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
-
A
I
A
D
--------------
Y
-
N
D
A
T
A
K
A
V
A
S
------
E
I
--
N
Q
A
G
G
H
A
V
A
-
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
V
-----
A
P
S
T
P
I
E
S
I
T
P
E
-
I
V
D
K
V
Y
N
I
N
V
K
G
V
I
W
G
-
I
Q
A
A
V
E
A
F
K
----
K
E
G
H
G
G
K
I
I
N
A
C
S
Q
A
---
G
H
V
-
G
N
P
E
L
A
-
V
--
Y
S
S
S
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
--
Y
C
P
G
I
V
K
T
P
M
WAEIDRQ
V
-----
S
E
--
A
A
G
K
P
L
G
Y
G
T
-
A
E
F
--
A
K
R
I
T
----
L
G
R
L
---------
S
--
E
P
-
E
D
V
A
A
C
V
S
Y
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
-------------
245
Blastp_CBE
83.16
32%
0
- C- -
-
1GEG
2
BUDC_KLEPN
E:
[3-252]
-----------------
K
V
A
L
V
T
G
A
G
Q
-----
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
-
A
I
A
D
--------------
Y
-
N
D
A
T
A
K
A
V
A
S
------
E
I
--
N
Q
A
G
G
H
A
V
A
-
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
V
-----
A
P
S
T
P
I
E
S
I
T
P
E
-
I
V
D
K
V
Y
N
I
N
V
K
G
V
I
W
G
-
I
Q
A
A
V
E
A
F
K
----
K
E
G
H
G
G
K
I
I
N
A
C
S
Q
A
---
G
H
V
-
G
N
P
E
L
A
-
V
--
Y
S
S
S
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
--
Y
C
P
G
I
V
K
T
P
M
WAEIDRQ
V
-----
S
E
--
A
A
G
K
P
L
G
Y
G
T
-
A
E
F
--
A
K
R
I
T
----
L
G
R
L
---------
S
--
E
P
-
E
D
V
A
A
C
V
S
Y
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
-------------
244
Blastp_CBE
83.16
32%
0
- C- -
-
1GEG
2
BUDC_KLEPN
F:
[3-252]
-----------------
K
V
A
L
V
T
G
A
G
Q
-----
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
-
A
I
A
D
--------------
Y
-
N
D
A
T
A
K
A
V
A
S
------
E
I
--
N
Q
A
G
G
H
A
V
A
-
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
V
-----
A
P
S
T
P
I
E
S
I
T
P
E
-
I
V
D
K
V
Y
N
I
N
V
K
G
V
I
W
G
-
I
Q
A
A
V
E
A
F
K
----
K
E
G
H
G
G
K
I
I
N
A
C
S
Q
A
---
G
H
V
-
G
N
P
E
L
A
-
V
--
Y
S
S
S
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
--
Y
C
P
G
I
V
K
T
P
M
WAEIDRQ
V
-----
S
E
--
A
A
G
K
P
L
G
Y
G
T
-
A
E
F
--
A
K
R
I
T
----
L
G
R
L
---------
S
--
E
P
-
E
D
V
A
A
C
V
S
Y
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
-------------
243
Blastp_CBE
83.16
32%
0
- C- -
-
1GEG
1
BUDC_KLEPN
G:
[3-252]
-----------------
K
V
A
L
V
T
G
A
G
Q
-----
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
-
A
I
A
D
--------------
Y
-
N
D
A
T
A
K
A
V
A
S
------
E
I
--
N
Q
A
G
G
H
A
V
A
-
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
V
-----
A
P
S
T
P
I
E
S
I
T
P
E
-
I
V
D
K
V
Y
N
I
N
V
K
G
V
I
W
G
-
I
Q
A
A
V
E
A
F
K
----
K
E
G
H
G
G
K
I
I
N
A
C
S
Q
A
---
G
H
V
-
G
N
P
E
L
A
-
V
--
Y
S
S
S
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
--
Y
C
P
G
I
V
K
T
P
M
WAEIDRQ
V
-----
S
E
--
A
A
G
K
P
L
G
Y
G
T
-
A
E
F
--
A
K
R
I
T
----
L
G
R
L
---------
S
--
E
P
-
E
D
V
A
A
C
V
S
Y
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
-------------
242
Blastp_CBE
83.16
32%
0
- C- -
-
1GEG
11
BUDC_KLEPN
H:
[3-252]
-----------------
K
V
A
L
V
T
G
A
G
Q
-----
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
-
A
I
A
D
--------------
Y
-
N
D
A
T
A
K
A
V
A
S
------
E
I
--
N
Q
A
G
G
H
A
V
A
-
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
V
-----
A
P
S
T
P
I
E
S
I
T
P
E
-
I
V
D
K
V
Y
N
I
N
V
K
G
V
I
W
G
-
I
Q
A
A
V
E
A
F
K
----
K
E
G
H
G
G
K
I
I
N
A
C
S
Q
A
---
G
H
V
-
G
N
P
E
L
A
-
V
--
Y
S
S
S
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
--
Y
C
P
G
I
V
K
T
P
M
WAEIDRQ
V
-----
S
E
--
A
A
G
K
P
L
G
Y
G
T
-
A
E
F
--
A
K
R
I
T
----
L
G
R
L
---------
S
--
E
P
-
E
D
V
A
A
C
V
S
Y
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
-------------
22
Blastp_CBE
82.09
42%
-103
- C7 -
-
5JC8
2
?
C:
[15-270]
--------------
L
Q
G
K
V
A
L
V
T
G
A
G
C
I
G
P
G
W
G
N
G
R
A
I
A
V
R
F
A
E
E
G
A
H
V
-
I
A
V
D
--------------
R
-
D
L
A
S
M
D
A
T
L
E
------
L
V
R
A
--
A
G
G
S
V
T
P
-
C
L
C
D
V
T
D
S
A
S
V
E
R
L
V
A
D
S
V
A
R
C
G
R
V
D
I
L
V
N
N
V
G
A
-
P
---
S
P
G
G
P
V
A
-
L
D
E
A
-
Q
W
A
M
Q
L
E
L
N
L
T
T
A
F
L
M
-
C
K
Y
V
L
P
V
M
---
E
Q
Q
G
G
--
G
A
I
V
N
I
A
S
T
S
---
G
I
R
W
T
G
A
A
Q
V
-
G
--
Y
A
A
A
K
A
G
M
I
Q
M
G
R
V
V
A
V
E
Y
A
A
K
N
V
R
V
N
S
--
V
V
P
G
L
L
H
T
P
M
-------
V
D
T
---------------
L
L
-
R
K
R
--
Q
A
R
I
P
----
M
P
F
M
---------
G
--
D
G
-
R
D
T
A
N
A
A
L
F
L
A
S
D
E
A
R
F
V
T
G
T
E
I
V
V
D
G
G
-------------
536
SP3
81.49
27%
-110
- C7 -
-
1FMC
2
HDHA_ECOLI
A:
[1-255]
M
F
N
S
D
N
----
L
--
R
L
D
G
K
C
A
I
I
T
G
A
G
A
-----
G
I
G
K
E
I
A
I
T
F
A
T
A
G
A
S
V
-
V
V
S
D
--------------
I
-
N
A
D
A
A
N
H
V
V
D
------
E
I
Q
Q
--
L
G
G
Q
A
F
A
-
C
R
C
D
I
T
S
E
Q
E
L
S
A
L
A
D
F
A
I
S
K
L
G
K
V
D
I
L
V
N
N
A
G
G
G
G
---
P
K
P
F
--
D
-
M
P
M
A
-
D
F
R
R
A
Y
E
L
N
V
F
S
F
F
H
L
-
S
Q
L
V
A
P
E
M
E
K
N
G
-----
G
G
V
I
L
T
I
T
S
M
A
---
A
E
N
-
K
N
I
N
M
T
-
S
--
Y
A
S
S
K
A
A
A
S
H
L
V
R
N
M
A
F
D
L
G
E
K
N
I
R
V
N
G
--
I
A
P
G
A
I
L
T
D
A
-------
L
-----
K
-----
S
V
I
T
P
E
I
E
-
Q
K
M
--
L
Q
H
T
P
----
I
R
R
L
---------
G
--
Q
P
-
Q
D
I
A
N
A
A
L
F
L
C
S
P
A
A
S
W
V
S
G
Q
I
L
T
V
S
G
G
G
V
Q
E
L
N
-------
49
Blastp_CBE
81.40
32%
-67
- C7 -
-
5OJG
2
DHRS4_CAEEL
B:
[2-260]
------
P
S
N
C
R
--
R
F
E
G
K
V
A
I
V
T
A
A
-----
T
K
G
I
G
L
A
I
A
E
R
L
L
D
E
G
A
S
V
-
V
I
G
S
--------------
R
-
N
Q
K
N
V
D
E
A
I
E
------
Y
L
--
K
N
K
G
L
T
K
V
A
G
I
A
G
H
I
A
S
T
D
D
Q
K
K
L
V
D
F
T
L
Q
K
F
G
K
I
N
I
L
V
N
N
H
G
I
N
P
---
A
F
G
H
I
L
E
-
V
S
D
Q
-
V
W
D
K
L
F
E
V
N
V
K
A
G
F
Q
M
-
T
K
L
V
H
P
H
I
---
A
K
E
G
G
--
G
A
I
I
F
N
A
S
Y
S
---
A
Y
K
-
S
P
P
G
I
A
-
A
--
Y
G
V
T
K
T
T
L
V
G
L
T
R
A
L
A
M
G
L
A
K
D
N
I
R
V
N
G
--
I
A
P
G
V
I
K
T
K
M
SQV----
L
-----
W
D
----
G
G
E
D
A
E
K
E
-
L
T
D
--
I
Q
E
I
A
----
L
G
R
L
---------
G
--
V
P
-
D
D
C
A
G
T
V
A
Y
L
A
S
D
D
S
S
Y
I
T
G
E
M
I
I
I
A
G
G
V
Q
A
R
L
--------
13
PsiBlast_PDB
81.24
32%
-70
- C7 -
-
5OJG
2
DHRS4_CAEEL
A:
[2-260]
------
P
S
N
C
R
--
R
F
E
G
K
V
A
I
V
T
A
A
-----
T
K
G
I
G
L
A
I
A
E
R
L
L
D
E
G
A
S
V
-
V
I
G
S
--------------
R
-
N
Q
K
N
V
D
E
A
I
E
------
Y
L
--
K
N
K
G
L
T
K
V
A
G
I
A
G
H
I
A
S
T
D
D
Q
K
K
L
V
D
F
T
L
Q
K
F
G
K
I
N
I
L
V
N
N
H
G
I
N
P
---
A
F
G
H
I
L
E
-
V
S
D
Q
-
V
W
D
K
L
F
E
V
N
V
K
A
G
F
Q
M
-
T
K
L
V
H
P
H
I
---
A
K
E
G
G
--
G
A
I
I
F
N
A
S
Y
S
---
A
Y
K
-
S
P
P
G
I
A
-
A
--
Y
G
V
T
K
T
T
L
V
G
L
T
R
A
L
A
M
G
L
A
K
D
N
I
R
V
N
G
--
I
A
P
G
V
I
K
T
K
M
SQV----
L
-----
W
D
----
G
G
E
D
A
E
K
E
-
L
T
D
--
I
Q
E
I
A
----
L
G
R
L
---------
G
--
V
P
-
D
D
C
A
G
T
V
A
Y
L
A
S
D
D
S
S
Y
I
T
G
E
M
I
I
I
A
G
G
V
Q
A
R
L
--------
23
Blastp_CBE
81.23
42%
-105
- C7 -
-
5JC8
4
?
B:
[15-270]
--------------
L
Q
G
K
V
A
L
V
T
G
A
G
C
I
G
P
G
W
G
N
G
R
A
I
A
V
R
F
A
E
E
G
A
H
V
-
I
A
V
D
--------------
R
-
D
L
A
S
M
D
A
T
L
E
------
L
V
R
A
--
A
G
G
S
V
T
P
-
C
L
C
D
V
T
D
S
A
S
V
E
R
L
V
A
D
S
V
A
R
C
G
R
V
D
I
L
V
N
N
V
G
A
-
P
---
S
P
G
G
P
V
A
-
L
D
E
A
-
Q
W
A
M
Q
L
E
L
N
L
T
T
A
F
L
M
-
C
K
Y
V
L
P
V
M
---
E
Q
Q
G
G
--
G
A
I
V
N
I
A
S
T
S
---
G
I
R
W
T
G
A
A
Q
V
-
G
--
Y
A
A
A
K
A
G
M
I
Q
M
G
R
V
V
A
V
E
Y
A
A
K
N
V
R
V
N
S
--
V
V
P
G
L
L
H
T
P
M
-------
V
D
T
K--------------
L
L
-
R
K
R
--
Q
A
R
I
P
----
M
P
F
M
---------
G
--
D
G
-
R
D
T
A
N
A
A
L
F
L
A
S
D
E
A
R
F
V
T
G
T
E
I
V
V
D
G
G
-------------
300
Blastp_CBE
81.16
33%
-26
- C7 -
-
3PGX
1
Y4146_MYCPA
A:
[12-277]
-------------
S
L
Q
G
R
V
A
F
I
T
G
A
A
R
-----
G
Q
G
R
S
H
A
V
R
L
A
A
E
G
A
D
I
-
I
A
C
D
ICAPVSASVT
Y
A
P
A
S
-
P
E
D
L
D
E
-
T
A
R
------
L
V
--
E
D
Q
G
R
K
A
L
T
-
R
V
L
D
V
R
D
D
A
A
L
R
E
L
V
A
D
G
M
E
Q
F
G
R
L
D
V
V
V
A
N
A
G
V
L
S
---
W
-
G
R
V
W
E
-
L
T
D
E
-
Q
W
D
T
V
I
G
V
N
L
T
G
T
W
R
T
-
L
R
A
T
V
P
A
M
I
----
E
A
G
N
G
G
S
I
V
V
V
S
S
S
A
---
G
L
K
-
A
T
P
G
N
G
-
H
--
Y
S
A
S
K
H
G
L
T
A
L
T
N
T
L
A
I
E
L
G
E
Y
G
I
R
V
N
S
--
I
H
P
Y
S
V
E
T
P
M
-------
I
------
E
--
P
E
A
M
M
E
I
F
A
R
-
H
P
S
--
F
V
H
S
F
PPMP
V
Q
P
N
---------
G
F
M
T
A
-
D
E
V
A
D
V
V
A
W
L
A
G
D
G
S
G
T
L
T
G
T
Q
I
P
V
D
K
G
A
------------
1
PsiBlast_PDB
80.97
42%
-99
- C7 -
-
5JC8
7
?
A:
[15-270]
--------------
L
Q
G
K
V
A
L
V
T
G
A
G
C
I
G
P
G
W
G
N
G
R
A
I
A
V
R
F
A
E
E
G
A
H
V
-
I
A
V
D
--------------
R
-
D
L
A
S
M
D
A
T
L
E
------
L
V
R
A
--
A
G
G
S
V
T
P
-
C
L
C
D
V
T
D
S
A
S
V
E
R
L
V
A
D
S
V
A
R
C
G
R
V
D
I
L
V
N
N
V
G
A
-
P
---
S
P
G
G
P
V
A
-
L
D
E
A
-
Q
W
A
M
Q
L
E
L
N
L
T
T
A
F
L
M
-
C
K
Y
V
L
P
V
M
---
E
Q
Q
G
G
--
G
A
I
V
N
I
A
S
T
S
---
G
I
R
W
T
G
A
A
Q
V
-
G
--
Y
A
A
A
K
A
G
M
I
Q
M
G
R
V
V
A
V
E
Y
A
A
K
N
V
R
V
N
S
--
V
V
P
G
L
L
H
T
P
M
-------
V
D
T
K
I
A
H
N
----
G
G
D
V
E
L
L
L
-
R
K
R
--
Q
A
R
I
P
----
M
P
F
M
---------
G
--
D
G
-
R
D
T
A
N
A
A
L
F
L
A
S
D
E
A
R
F
V
T
G
T
E
I
V
V
D
G
G
-------------
298
Blastp_CBE
80.87
33%
-27
- C7 -
-
3PGX
1
Y4146_MYCPA
C:
[12-277]
-------------
S
L
Q
G
R
V
A
F
I
T
G
A
A
R
-----
G
Q
G
R
S
H
A
V
R
L
A
A
E
G
A
D
I
-
I
A
C
D
ICAPVSASVTYAPA
S
-
P
E
D
L
D
E
-
T
A
R
------
L
V
--
E
D
Q
G
R
K
A
L
T
-
R
V
L
D
V
R
D
D
A
A
L
R
E
L
V
A
D
G
M
E
Q
F
G
R
L
D
V
V
V
A
N
A
G
V
L
S
---
W
-
G
R
V
W
E
-
L
T
D
E
-
Q
W
D
T
V
I
G
V
N
L
T
G
T
W
R
T
-
L
R
A
T
V
P
A
M
I
----
E
A
G
N
G
G
S
I
V
V
V
S
S
S
A
---
G
L
K
-
A
T
P
G
N
G
-
H
--
Y
S
A
S
K
H
G
L
T
A
L
T
N
T
L
A
I
E
L
G
E
Y
G
I
R
V
N
S
--
I
H
P
Y
S
V
E
T
P
M
-------
I
------
E
--
P
E
A
M
M
E
I
F
A
R
-
H
P
S
--
F
V
H
S
F
PPMP
V
Q
P
N
---------
G
FM
T
A
-
D
E
V
A
D
V
V
A
W
L
A
G
D
G
S
G
T
L
T
G
T
Q
I
P
V
D
K
G
A
------------
297
Blastp_CBE
80.51
33%
-27
- C7 -
-
3PGX
1
Y4146_MYCPA
D:
[12-277]
-------------
S
L
Q
G
R
V
A
F
I
T
G
A
A
R
-----
G
Q
G
R
S
H
A
V
R
L
A
A
E
G
A
D
I
-
I
A
C
D
ICAPVSASVTYAPA
S
-
P
E
D
L
D
E
-
T
A
R
------
L
V
--
E
D
Q
G
R
K
A
L
T
-
R
V
L
D
V
R
D
D
A
A
L
R
E
L
V
A
D
G
M
E
Q
F
G
R
L
D
V
V
V
A
N
A
G
V
L
S
---
W
-
G
R
V
W
E
-
L
T
D
E
-
Q
W
D
T
V
I
G
V
N
L
T
G
T
W
R
T
-
L
R
A
T
V
P
A
M
I
----
E
A
G
N
G
G
S
I
V
V
V
S
S
S
A
---
G
L
K
-
A
T
P
G
N
G
-
H
--
Y
S
A
S
K
H
G
L
T
A
L
T
N
T
L
A
I
E
L
G
E
Y
G
I
R
V
N
S
--
I
H
P
Y
S
V
E
T
P
M
-------
I
------
E
--
P
E
A
M
M
E
I
F
A
R
-
H
P
S
--
F
V
H
S
F
PPMP
V
Q
P
N
---------
G
FM
T
A
-
D
E
V
A
D
V
V
A
W
L
A
G
D
G
S
G
T
L
T
G
T
Q
I
P
V
D
K
G
A
------------
35
Blastp_CBE
80.50
36%
-114
- C7 -
-
5K9Z
1
?
B:
[10-257]
---------
S
E
--
R
L
K
D
R
V
A
L
V
T
G
A
A
S
-----
G
I
G
A
A
T
A
R
L
M
A
Q
E
G
A
F
V
-
V
L
A
D
--------------
V
-
D
E
H
A
G
Q
A
L
A
R
------------
E
L
R
D
A
T
F
-
A
Y
T
D
V
S
V
E
A
Q
V
A
A
A
V
D
E
A
L
R
L
H
G
R
L
D
C
M
V
N
N
A
G
F
V
G
---
A
Y
G
S
I
L
E
-
T
S
A
A
-
A
W
H
A
T
L
G
V
L
L
D
G
V
F
Y
G
-
I
K
H
A
A
R
A
M
V
K
Q
G
S
-----
G
C
I
L
S
V
A
S
T
A
---
G
V
M
-
G
G
L
G
P
H
-
A
--
Y
T
S
A
K
H
A
V
I
G
L
T
R
S
A
A
S
E
L
A
P
R
G
V
R
V
N
A
--
V
A
P
G
T
T
V
T
E
M
-------
M
-----
V
Q
--
G
R
G
S
R
Q
A
A
I
--
D
A
A
--
T
R
A
S
P
----
L
G
T
P
---------
L
--
M
P
-
Q
E
I
A
A
A
L
V
Y
L
A
S
D
D
A
R
H
V
N
A
H
T
L
V
V
D
S
G
V
T
V
A
---------
431
Blastp_CBE
79.54
33%
-104
- C7 -
-
3LQF
2
?
D:
[4-252]
-------
R
T
V
F
--
R
L
D
G
A
C
A
A
V
T
G
A
G
S
-----
G
I
G
L
E
I
C
R
A
F
A
A
S
G
A
R
L
-
I
L
I
D
--------------
R
-
E
A
A
A
L
D
R
A
A
Q
----------
E
L
G
A
A
V
A
A
R
-
I
V
A
D
V
T
D
A
E
A
M
T
A
A
A
A
E
A
E
A
V
-
A
P
V
S
I
L
V
N
S
A
G
I
-
A
---
R
L
H
D
A
L
E
-
T
D
D
A
-
T
W
R
Q
V
M
A
V
N
V
D
G
M
F
W
A
-
S
R
A
F
G
R
A
M
V
A
R
G
A
-----
G
A
I
V
N
L
G
S
M
S
---
G
T
I
-
V
N
R
P
Q
F
-
A
SS
Y
M
A
S
K
G
A
V
H
Q
L
T
R
A
L
A
A
E
W
A
G
R
G
V
R
V
N
A
--
L
A
P
G
Y
V
A
T
E
M
-------
T
-----
L
--------------
K
M
R
--
E
R
P
E
L
----
F
E
T
W
LDMTPMGRC
G
--
E
P
-
S
E
I
A
A
A
A
L
F
L
A
S
P
A
A
S
Y
V
T
G
A
I
L
A
V
D
G
G
Y
T
-----------
56
Blastp_CBE
79.52
33%
-94
- C7 -
-
3RRO
5
FABG_VIBCH
B:
[5-247]
-------
S
Q
F
M
--
N
L
E
G
K
V
A
L
V
T
G
A
-
S
R
G
I
----
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
-
I
G
T
A
--------------
T
-
S
E
S
G
A
Q
A
I
S
D
------
Y
L
-----
G
D
N
G
K
G
-
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
V
D
I
L
V
N
N
A
G
I
T
----
R
D
N
L
L
M
R
-
M
K
E
E
-
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
-
S
K
A
V
L
R
G
M
M
K
K
R
-----
Q
G
R
I
I
N
V
G
S
V
V
---
G
T
M
-
G
N
A
G
Q
A
-
N
--
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
--
V
A
P
G
F
I
E
T
D
----------------------
M
T
K
A
L
N
-
D
E
Q
--
R
T
A
T
L
----
A
Q
V
P
AGRL-----
G
--
D
P
-
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
-------------
20
PsiBlast_PDB
78.98
33%
-89
- C7 -
-
3RRO
5
FABG_VIBCH
A:
[5-247]
-------
S
Q
F
M
--
N
L
E
G
K
V
A
L
V
T
G
A
-
S
R
G
I
----
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
-
I
G
T
A
--------------
T
-
S
E
S
G
A
Q
A
I
S
D
------
Y
L
-----
G
D
N
G
K
G
-
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
V
D
I
L
V
N
N
A
G
I
T
----
R
D
N
L
L
M
R
-
M
K
E
E
-
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
-
S
K
A
V
L
R
G
M
M
K
K
R
-----
Q
G
R
I
I
N
V
G
S
V
V
---
G
T
M
-
G
N
A
G
Q
A
-
N
--
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
--
V
A
P
G
F
I
E
T
D
----------------------
M
T
K
A
L
N
-
D
E
Q
--
R
T
A
T
L
----
A
Q
V
P
AG
R
L
-----
G
--
D
P
-
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
-------------
32
Blastp_CBE
78.96
33%
-52
- C7 -
-
4FN4
2
?
B:
[3-253]
----------
Q
--
S
L
K
N
K
V
V
I
V
T
G
A
G
S
-----
G
I
G
R
A
I
A
K
K
F
A
L
N
D
S
I
V
-
V
A
V
E
--------------
L
L
E
D
R
L
N
Q
I
V
Q
E
------
L
---
R
G
M
G
K
E
V
L
G
-
V
K
A
D
V
S
K
K
K
D
V
E
E
F
V
R
R
T
F
E
T
Y
S
R
I
D
V
L
C
N
N
A
G
I
M
D
---
G
V
T
P
V
A
E
-
V
S
D
E
-
L
W
E
R
V
L
A
V
N
L
Y
S
A
F
Y
S
-
S
R
A
V
I
P
I
M
L
K
Q
G
-----
K
G
V
I
V
N
T
A
S
I
A
---
G
I
R
-
G
G
F
A
G
A
-
P
--
Y
T
V
A
K
H
G
L
I
G
L
T
R
S
I
A
A
H
Y
G
D
Q
G
I
R
A
V
A
--
V
L
P
G
T
V
K
T
N
I
-------
G
-----
L
G
--
S
S
K
P
S
E
L
G
M
R
-
T
L
T
--
K
L
M
S
L
----
S
S
R
L
---------
A
--
E
P
-
E
D
I
A
N
V
I
V
F
L
A
S
D
E
A
S
F
V
N
G
D
A
V
V
V
D
G
G
L
T
V
----------
31
Blastp_CBE
78.89
33%
-51
- C7 -
-
4FN4
2
?
C:
[3-253]
----------
Q
--
S
L
K
N
K
V
V
I
V
T
G
A
G
S
-----
G
I
G
R
A
I
A
K
K
F
A
L
N
D
S
I
V
-
V
A
V
E
--------------
L
L
E
D
R
L
N
Q
I
V
Q
E
------
L
---
R
G
M
G
K
E
V
L
G
-
V
K
A
D
V
S
K
K
K
D
V
E
E
F
V
R
R
T
F
E
T
Y
S
R
I
D
V
L
C
N
N
A
G
I
M
D
---
G
V
T
P
V
A
E
-
V
S
D
E
-
L
W
E
R
V
L
A
V
N
L
Y
S
A
F
Y
S
-
S
R
A
V
I
P
I
M
L
K
Q
G
-----
K
G
V
I
V
N
T
A
S
I
A
---
G
I
R
-
G
G
F
A
G
A
-
P
--
Y
T
V
A
K
H
G
L
I
G
L
T
R
S
I
A
A
H
Y
G
D
Q
G
I
R
A
V
A
--
V
L
P
G
T
V
K
T
N
I
-------
G
-----
L
G
--
S
S
K
P
S
E
L
G
M
R
-
T
L
T
--
K
L
M
S
L
----
S
S
R
L
---------
A
--
E
P
-
E
D
I
A
N
V
I
V
F
L
A
S
D
E
A
S
F
V
N
G
D
A
V
V
V
D
G
G
L
T
V
----------
108
Blastp_CBE
78.81
34%
-113
- C7 -
-
5HA5
6
?
C:
[4-250]
--------------
L
K
E
K
L
V
L
V
T
G
A
G
R
-----
G
L
G
A
A
I
S
S
G
A
A
E
Q
G
A
R
V
-
I
L
V
D
--------------
I
-
D
G
T
A
A
K
A
Q
A
D
------
A
L
T
A
K
--
G
F
V
A
E
G
-
H
A
L
D
V
T
D
R
D
A
V
A
A
L
A
D
D
I
L
S
R
F
G
G
L
D
V
L
V
N
N
A
G
V
A
G
---
R
A
A
F
D
Q
P
-
E
A
V
E
-
V
W
D
R
V
I
G
V
N
L
E
G
A
F
N
V
-
S
H
A
L
V
P
A
L
K
------
A
A
K
G
N
V
V
H
L
C
S
V
A
---
G
F
V
-
S
G
G
S
T
A
-
G
--
Y
V
V
S
K
G
A
I
R
S
L
T
Q
V
M
A
R
D
L
A
P
H
G
I
R
V
N
A
--
V
A
P
G
I
M
M
S
----------------------------
T
-
D
W
F
--
M
N
R
V
M
----
M
K
R
I
---------
G
--
E
T
-
S
E
V
V
D
P
V
V
F
L
A
S
P
M
A
S
Y
I
T
G
T
I
L
P
V
D
G
G
F
L
A
A
---------
434
Blastp_CBE
78.58
33%
-103
- C7 -
-
2WSB
3
?
D:
[4-252]
-------
R
T
V
F
--
R
L
D
G
A
C
A
A
V
T
G
A
G
S
-----
G
I
G
L
E
I
C
R
A
F
A
A
S
G
A
R
L
-
I
L
I
D
--------------
R
-
E
A
A
A
L
D
R
A
A
Q
----------
E
L
G
A
A
V
A
A
R
-
I
V
A
D
V
T
D
A
E
A
M
T
A
A
A
A
E
A
E
A
V
-
A
P
V
S
I
L
V
N
S
A
G
I
-
A
---
R
L
H
D
A
L
E
-
T
D
D
A
-
T
W
R
Q
V
M
A
V
N
V
D
G
M
F
W
A
-
S
R
A
F
G
R
A
M
V
A
R
G
A
-----
G
A
I
V
N
L
G
S
M
S
---
G
T
I
-
V
N
R
P
Q
F
-
A
SS
Y
M
A
S
K
G
A
V
H
Q
L
T
R
A
L
A
A
E
W
A
G
R
G
V
R
V
N
A
--
L
A
P
G
Y
V
A
T
E
M
-------
T
-----
L
--------------
K
M
R
--
E
R
P
E
L
----
F
E
T
W
LDMTPMGRC
G
--
E
P
-
S
E
I
A
A
A
A
L
F
L
A
S
P
A
A
S
Y
V
T
G
A
I
L
A
V
D
G
G
Y
T
-----------
440
Blastp_CBE
78.51
33%
-101
- C7 -
-
2WDZ
2
?
B:
[4-252]
-------
R
T
V
F
--
R
L
D
G
A
C
A
A
V
T
G
A
G
S
-----
G
I
G
L
E
I
C
R
A
F
A
A
S
G
A
R
L
-
I
L
I
D
--------------
R
-
E
A
A
A
L
D
R
A
A
Q
----------
E
L
G
A
A
V
A
A
R
-
I
V
A
D
V
T
D
A
E
A
M
T
A
A
A
A
E
A
E
A
V
-
A
P
V
S
I
L
V
N
S
A
G
I
-
A
---
R
L
H
D
A
L
E
-
T
D
D
A
-
T
W
R
Q
V
M
A
V
N
V
D
G
M
F
W
A
-
S
R
A
F
G
R
A
M
V
A
R
G
A
-----
G
A
I
V
N
L
G
S
M
S
---
G
T
I
-
V
N
R
P
Q
F
-
A
SS
Y
M
A
S
K
G
A
V
H
Q
L
T
R
A
L
A
A
E
W
A
G
R
G
V
R
V
N
A
--
L
A
P
G
Y
V
A
T
E
M
-------
T
-----
L
--------------
K
M
R
--
E
R
P
E
L
----
F
E
T
W
LDMTPMGRC
G
--
E
P
-
S
E
I
A
A
A
A
L
F
L
A
S
P
A
A
S
Y
V
T
G
A
I
L
A
V
D
G
G
Y
T
-----------
107
Blastp_CBE
78.30
34%
-92
- C7 -
-
5HA5
4
?
D:
[4-250]
--------------
L
K
E
K
L
V
L
V
T
G
A
G
R
-----
G
L
G
A
A
I
S
S
G
A
A
E
Q
G
A
R
V
-
I
L
V
D
--------------
I
-
D
G
T
A
A
K
A
Q
A
D
------
A
L
T
A
K
--
G
F
V
A
E
G
-
H
A
L
D
V
T
D
R
D
A
V
A
A
L
A
D
D
I
L
S
R
F
G
G
L
D
V
L
V
N
N
A
G
V
A
G
---
R
A
A
F
D
Q
P
-
E
A
V
E
-
V
W
D
R
V
I
G
V
N
L
E
G
A
F
N
V
-
S
H
A
L
V
P
A
L
K
------
A
A
K
G
N
V
V
H
L
C
S
V
A
---
G
F
V
-
S
G
G
S
T
A
-
G
--
Y
V
V
S
K
G
A
I
R
S
L
T
Q
V
M
A
R
D
L
A
P
H
G
I
R
V
N
A
--
V
A
P
G
I
M
M
S
E
M
-------
A
VA----------
G
-----
T
-
D
W
F
--
M
N
R
V
M
----
M
K
R
I
---------
G
--
E
T
-
S
E
V
V
D
P
V
V
F
L
A
S
P
M
A
S
Y
I
T
G
T
I
L
P
V
D
G
G
F
L
A
A
---------
6
PsiBlast_PDB
78.09
32%
-51
- C7 -
-
4FN4
3
?
A:
[3-253]
----------
Q
--
S
L
K
N
K
V
V
I
V
T
G
A
G
S
-----
G
I
G
R
A
I
A
K
K
F
A
L
N
D
S
I
V
-
V
A
V
E
--------------
L
L
E
D
R
L
N
Q
I
V
Q
E
------
L
---
R
G
M
G
K
E
V
L
G
-
V
K
A
D
V
S
K
K
K
D
V
E
E
F
V
R
R
T
F
E
T
Y
S
R
I
D
V
L
C
N
N
A
G
I
M
D
---
G
V
T
P
V
A
E
-
V
S
D
E
-
L
W
E
R
V
L
A
V
N
L
Y
S
A
F
Y
S
-
S
R
A
V
I
P
I
M
L
K
Q
G
-----
K
G
V
I
V
N
T
A
S
I
A
---
G
I
R
-
G
G
F
A
G
A
-
P
--
Y
T
V
A
K
H
G
L
I
G
L
T
R
S
I
A
A
H
Y
G
D
Q
G
I
R
A
V
A
--
V
L
P
G
T
V
K
T
N
I
-------
G
-----
L
G
--
S
S
K
P
S
E
L
G
M
R
-
T
L
T
--
K
L
M
S
L
----
S
S
R
L
---------
A
--
E
P
-
E
D
I
A
N
V
I
V
F
L
A
S
D
E
A
S
F
V
N
G
D
A
V
V
V
D
G
G
L
T
V
----------
30
Blastp_CBE
77.84
33%
-53
- C7 -
-
4FN4
4
?
D:
[3-253]
----------
Q
--
S
L
K
N
K
V
V
I
V
T
G
A
G
S
-----
G
I
G
R
A
I
A
K
K
F
A
L
N
D
S
I
V
-
V
A
V
E
--------------
L
L
E
D
R
L
N
Q
I
V
Q
E
------
L
---
R
G
M
G
K
E
V
L
G
-
V
K
A
D
V
S
K
K
K
D
V
E
E
F
V
R
R
T
F
E
T
Y
S
R
I
D
V
L
C
N
N
A
G
I
M
D
---
G
V
T
P
V
A
E
-
V
S
D
E
-
L
W
E
R
V
L
A
V
N
L
Y
S
A
F
Y
S
-
S
R
A
V
I
P
I
M
L
K
Q
G
-----
K
G
V
I
V
N
T
A
S
I
A
---
G
I
R
-
G
G
F
A
G
A
-
P
--
Y
T
V
A
K
H
G
L
I
G
L
T
R
S
I
A
A
H
Y
G
D
Q
G
I
R
A
V
A
--
V
L
P
G
T
V
K
T
N
I
-------
G
-----
L
G
--
S
S
K
P
S
E
L
G
M
R
-
T
L
T
--
K
L
M
S
L
----
S
S
R
L
---------
A
--
E
P
-
E
D
I
A
N
V
I
V
F
L
A
S
D
E
A
S
F
V
N
G
D
A
V
V
V
D
G
G
L
T
V
----------
109
Blastp_CBE
76.99
34%
-112
- C7 -
-
5HA5
8
?
B:
[4-250]
--------------
L
K
E
K
L
V
L
V
T
G
A
G
R
-----
G
L
G
A
A
I
S
S
G
A
A
E
Q
G
A
R
V
-
I
L
V
D
--------------
I
-
D
G
T
A
A
K
A
Q
A
D
------
A
L
T
A
K
--
G
F
V
A
E
G
-
H
A
L
D
V
T
D
R
D
A
V
A
A
L
A
D
D
I
L
S
R
F
G
G
L
D
V
L
V
N
N
A
G
V
A
G
---
R
A
A
F
D
Q
P
-
E
A
V
E
-
V
W
D
R
V
I
G
V
N
L
E
G
A
F
N
V
-
S
H
A
L
V
P
A
L
K
------
A
A
K
G
N
V
V
H
L
C
S
V
A
---
G
F
V
-
S
G
G
S
T
A
-
G
--
Y
V
V
S
K
G
A
I
R
S
L
T
Q
V
M
A
R
D
L
A
P
H
G
I
R
V
N
A
--
V
A
P
G
I
M
M
S
E
M
--------------------------
T
-
D
W
F
--
M
N
R
V
M
----
M
K
R
I
---------
G
--
E
T
-
S
E
V
V
D
P
V
V
F
L
A
S
P
M
A
S
Y
I
T
G
T
I
L
P
V
D
G
G
F
L
A
A
---------
194
Blastp_CBE
76.80
33%
-80
- C7 -
-
2CFC
2
HCDR_XANP2
C:
[3-248]
-----------------
R
V
A
I
V
T
G
A
S
S
-----
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
-
A
A
L
D
--------------
L
-
S
A
E
T
L
E
E
T
A
R
-------
T
H
W
H
A
Y
A
D
K
V
L
R
-
V
R
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
T
G
NS-
E
A
G
V
L
H
T
-
T
P
V
E
-
Q
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
-
C
R
A
V
L
P
H
M
L
L
Q
G
A
-----
G
V
I
V
N
I
A
S
V
A
---
S
L
V
-
A
F
P
G
R
S
-
A
--
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
--
V
C
P
G
M
I
E
T
P
M
-------
T
QWR--
L
D
-------
Q
P
E
L
R
-
D
Q
V
--
L
A
R
I
P
----
Q
K
E
I
---------
G
--
T
A
-
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
-----------
196
Blastp_CBE
76.30
33%
-81
- C7 -
-
2CFC
2
HCDR_XANP2
A:
[3-248]
-----------------
R
V
A
I
V
T
G
A
S
S
-----
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
-
A
A
L
D
--------------
L
-
S
A
E
T
L
E
E
T
A
R
-------
T
H
W
H
A
Y
A
D
K
V
L
R
-
V
R
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
T
G
NS-
E
A
G
V
L
H
T
-
T
P
V
E
-
Q
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
-
C
R
A
V
L
P
H
M
L
L
Q
G
A
-----
G
V
I
V
N
I
A
S
V
A
---
S
L
V
-
A
F
P
G
R
S
-
A
--
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
--
V
C
P
G
M
I
E
T
P
M
-------
T
Q
W
R
--
L
D
-------
Q
P
E
L
R
-
D
Q
V
--
L
A
R
I
P
----
Q
K
E
I
---------
G
--
T
A
-
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
-----------
195
Blastp_CBE
76.09
33%
-81
- C7 -
-
2CFC
2
HCDR_XANP2
B:
[3-248]
-----------------
R
V
A
I
V
T
G
A
S
S
-----
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
-
A
A
L
D
--------------
L
-
S
A
E
T
L
E
E
T
A
R
-------
T
H
W
H
A
Y
A
D
K
V
L
R
-
V
R
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
T
G
NS-
E
A
G
V
L
H
T
-
T
P
V
E
-
Q
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
-
C
R
A
V
L
P
H
M
L
L
Q
G
A
-----
G
V
I
V
N
I
A
S
V
A
---
S
L
V
-
A
F
P
G
R
S
-
A
--
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
--
V
C
P
G
M
I
E
T
P
M
-------
T
QWR--
L
D
-------
Q
P
E
L
R
-
D
Q
V
--
L
A
R
I
P
----
Q
K
E
I
---------
G
--
T
A
-
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
-----------
193
Blastp_CBE
75.66
33%
-80
- C7 -
-
2CFC
2
HCDR_XANP2
D:
[3-248]
-----------------
R
V
A
I
V
T
G
A
S
S
-----
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
-
A
A
L
D
--------------
L
-
S
A
E
T
L
E
E
T
A
R
-------
T
H
W
H
A
Y
A
D
K
V
L
R
-
V
R
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
T
G
NS-
E
A
G
V
L
H
T
-
T
P
V
E
-
Q
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
-
C
R
A
V
L
P
H
M
L
L
Q
G
A
-----
G
V
I
V
N
I
A
S
V
A
---
S
L
V
-
A
F
P
G
R
S
-
A
--
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
--
V
C
P
G
M
I
E
T
P
M
-------
T
QWR--
L
D
-------
Q
P
E
L
R
-
D
Q
V
--
L
A
R
I
P
----
Q
K
E
I
---------
G
--
T
A
-
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
-----------
433
Blastp_CBE
75.45
33%
-109
- C7 -
-
3LQF
2
?
B:
[4-252]
-------
R
T
V
F
--
R
L
D
G
A
C
A
A
V
T
G
A
G
S
-----
G
I
G
L
E
I
C
R
A
F
A
A
S
G
A
R
L
-
I
L
I
D
--------------
R
-
E
A
A
A
L
D
R
A
A
Q
----------
E
L
G
A
A
V
A
A
R
-
I
V
A
D
V
T
D
A
E
A
M
T
A
A
A
A
E
A
E
A
V
-
A
P
V
S
I
L
V
N
S
A
G
I
-
A
---
R
L
H
D
A
L
E
-
T
D
D
A
-
T
W
R
Q
V
M
A
V
N
V
D
G
M
F
W
A
-
S
R
A
F
G
-
A
M
V
A
R
G
A
-----
G
A
I
V
N
L
G
S
M
S
---
G
T
I
-
V
N
R
P
Q
F
-
A
S
S
Y
M
A
S
K
G
A
V
H
Q
L
T
R
A
L
A
A
E
W
A
G
R
G
V
R
V
N
A
--
L
A
P
G
Y
V
A
T
E
M
-------
T
-----
L
--------------
K
M
R
--
E
R
P
E
L
----
F
E
T
W
L
D
M
TPMGRC
G
--
E
P
-
S
E
I
A
A
A
A
L
F
L
A
S
P
A
A
S
Y
V
T
G
A
I
L
A
V
D
G
G
Y
T
-----------
295
Blastp_CBE
75.27
35%
-62
- C7 -
-
5U2W
5
?
B:
[12-254]
--------------
L
Q
G
K
R
A
L
V
T
G
-
G
S
R
G
I
----
G
A
A
I
A
K
R
L
A
A
D
G
A
D
V
--
A
I
T
--------------
Y
-
E
K
S
A
E
R
A
Q
A
V
------
V
A
G
I
E
A
L
G
R
R
A
I
A
-
I
Q
A
D
S
A
D
P
V
A
V
R
N
A
V
D
R
V
A
E
A
F
G
G
L
D
I
L
V
N
N
A
G
I
F
----
R
A
G
S
L
D
D
-
L
T
L
D
-
D
I
D
A
T
L
N
V
N
V
R
A
V
I
V
A
-
S
Q
A
A
A
R
H
L
-------
G
E
G
G
R
I
V
S
T
G
S
C
L
---
A
T
R
-
V
P
D
A
G
M
S
L
--
Y
A
A
S
K
A
A
L
I
G
W
T
Q
G
L
A
R
D
L
G
P
R
G
I
T
V
N
I
--
V
H
P
G
S
T
D
T
D
M
-------------
N
P
--
A
D
G
A
H
A
-----
D
A
Q
--
R
S
R
M
A
----
I
Q
Q
Y
---------
G
--
K
A
-
D
D
V
A
A
L
V
A
F
V
V
G
P
E
G
R
S
I
N
G
T
G
L
T
I
D
G
G
A
N
A
----------
51
Blastp_CBE
74.46
31%
-74
- C7 -
-
4URE
1
?
B:
[3-244]
--------------
L
E
G
K
T
A
L
V
T
G
A
G
N
-----
G
I
G
R
T
I
A
L
T
Y
A
A
E
G
A
N
V
-
V
V
S
D
--------------
I
-
S
D
E
W
G
R
E
T
--------
L
A
L
I
E
G
K
G
G
K
A
V
F
-
Q
H
A
D
T
A
H
P
E
D
H
D
E
L
I
A
A
A
K
R
A
F
G
R
L
D
I
A
C
N
N
A
G
I
S
G
---
E
F
T
P
T
A
E
-
T
T
D
A
-
Q
W
Q
R
V
I
G
I
N
L
S
G
V
F
Y
G
-
V
R
A
Q
I
R
A
M
L
E
T
G
G
-----
G
A
I
V
N
I
S
S
I
A
GQI
G
I
E
-
G
I
T
P
------
Y
T
A
A
K
H
G
V
V
G
L
T
K
T
V
A
W
E
Y
G
S
K
G
I
R
I
N
S
--
V
G
P
A
F
I
N
T
T
L
-------
V
-----
Q
N
--
V
P
L
E
T
R
R
Q
L
E
-
Q
M
H
--
A
L
R
R
L
----
G
E
T
E
----------------
E
V
A
N
L
V
A
W
L
S
S
D
K
A
S
F
V
T
G
S
Y
Y
A
V
D
G
G
-------------
294
Blastp_CBE
74.26
35%
-60
- C7 -
-
5U2W
5
?
C:
[12-254]
--------------
L
Q
G
K
R
A
L
V
T
G
-
G
S
R
G
I
----
G
A
A
I
A
K
R
L
A
A
D
G
A
D
V
--
A
I
T
--------------
Y
-
E
K
S
A
E
R
A
Q
A
V
------
V
A
G
I
E
A
L
G
R
R
A
I
A
-
I
Q
A
D
S
A
D
P
V
A
V
R
N
A
V
D
R
V
A
E
A
F
G
G
L
D
I
L
V
N
N
A
G
I
F
----
R
A
G
S
L
D
D
-
L
T
L
D
-
D
I
D
A
T
L
N
V
N
V
R
A
V
I
V
A
-
S
Q
A
A
A
R
H
L
-------
G
E
G
G
R
I
V
S
T
G
S
C
L
---
A
T
R
-
V
P
D
A
G
M
S
L
--
Y
A
A
S
K
A
A
L
I
G
W
T
Q
G
L
A
R
D
L
G
P
R
G
I
T
V
N
I
--
V
H
P
G
S
T
D
T
D
M
-------------
N
P
--
A
D
G
A
H
A
-----
D
A
Q
--
R
S
R
M
A
----
I
Q
Q
Y
---------
G
--
K
A
-
D
D
V
A
A
L
V
A
F
V
V
G
P
E
G
R
S
I
N
G
T
G
L
T
I
D
G
G
A
N
A
----------
293
Blastp_CBE
74.03
35%
-62
- C7 -
-
5U2W
5
?
D:
[12-254]
--------------
L
Q
G
K
R
A
L
V
T
G
-
G
S
R
G
I
----
G
A
A
I
A
K
R
L
A
A
D
G
A
D
V
--
A
I
T
--------------
Y
-
E
K
S
A
E
R
A
Q
A
V
------
V
A
G
I
E
A
L
G
R
R
A
I
A
-
I
Q
A
D
S
A
D
P
V
A
V
R
N
A
V
D
R
V
A
E
A
F
G
G
L
D
I
L
V
N
N
A
G
I
F
----
R
A
G
S
L
D
D
-
L
T
L
D
-
D
I
D
A
T
L
N
V
N
V
R
A
V
I
V
A
-
S
Q
A
A
A
R
H
L
-------
G
E
G
G
R
I
V
S
T
G
S
C
L
---
A
T
R
-
V
P
D
A
G
M
S
L
--
Y
A
A
S
K
A
A
L
I
G
W
T
Q
G
L
A
R
D
L
G
P
R
G
I
T
V
N
I
--
V
H
P
G
S
T
D
T
D
M
-------------
N
P
--
A
D
G
A
H
A
-----
D
A
Q
--
R
S
R
M
A
----
I
Q
Q
Y
---------
G
--
K
A
-
D
D
V
A
A
L
V
A
F
V
V
G
P
E
G
R
S
I
N
G
T
G
L
T
I
D
G
G
A
N
A
----------
296
Blastp_CBE
73.20
35%
-60
- C7 -
-
5U2W
5
?
A:
[12-254]
--------------
L
Q
G
K
R
A
L
V
T
G
-
G
S
R
G
I
----
G
A
A
I
A
K
R
L
A
A
D
G
A
D
V
--
A
I
T
--------------
Y
-
E
K
S
A
E
R
A
Q
A
V
------
V
A
G
I
E
A
L
G
R
R
A
I
A
-
I
Q
A
D
S
A
D
P
V
A
V
R
N
A
V
D
R
V
A
E
A
F
G
G
L
D
I
L
V
N
N
A
G
I
F
----
R
A
G
S
L
D
D
-
L
T
L
D
-
D
I
D
A
T
L
N
V
N
V
R
A
V
I
V
A
-
S
Q
A
A
A
R
H
L
-------
G
E
G
G
R
I
V
S
T
G
S
C
L
---
A
T
R
-
V
P
D
A
G
M
S
L
--
Y
A
A
S
K
A
A
L
I
G
W
T
Q
G
L
A
R
D
L
G
P
R
G
I
T
V
N
I
--
V
H
P
G
S
T
D
T
D
M
-------------
N
P
--
A
D
G
A
H
A
-----
D
A
Q
--
R
S
R
M
A
----
I
Q
Q
Y
---------
G
--
K
A
-
D
D
V
A
A
L
V
A
F
V
V
G
P
E
G
R
S
I
N
G
T
G
L
T
I
D
G
G
A
N
A
----------
185
Blastp_CBE
72.13
37%
-25
- C7 -
-
5JLA
1
?
D:
[12-253]
---------
S
A
--
E
F
N
G
A
I
A
V
V
T
G
A
G
S
-----
G
I
G
R
A
C
A
E
L
L
S
R
S
G
A
N
V
-
I
V
A
D
--------------
R
-
D
I
E
A
A
T
R
V
A
R
ATGGKT
L
V
L
D
V
G
E
D
A
S
V
T
A
-
A
A
N
E
V
R
A
-------------
R
Y
G
V
A
D
V
L
V
N
C
A
G
V
L
Q
RTL
P
P
G
---
E
-
L
A
Q
R
-
E
W
D
V
V
S
R
I
D
L
R
G
T
Y
L
C
C
A
A
F
G
A
P
-
M
A
D
R
R
-----
R
G
S
I
V
N
I
A
S
V
A
---
G
M
R
-
S
G
-
P
L
H
-
A
--
Y
G
P
A
K
A
G
V
I
S
L
T
E
T
L
A
G
E
W
G
P
K
G
V
R
V
N
C
--
V
S
P
G
F
T
Q
T
P
A
-------
L
----------
E
R
G
F
T
T
H
T
L
-
K
A
D
VL
R
D
A
A
A
----
L
G
H
I
---------
V
--
S
A
-
N
E
I
A
E
A
V
V
F
L
A
S
E
R
A
S
A
I
T
G
V
N
L
P
V
D
A
G
-------------
186
Blastp_CBE
71.64
37%
-23
- C7 -
-
5JLA
1
?
C:
[12-253]
---------
S
A
--
E
F
N
G
A
I
A
V
V
T
G
A
G
S
-----
G
I
G
R
A
C
A
E
L
L
S
R
S
G
A
N
V
-
I
V
A
D
--------------
R
-
D
I
E
A
A
T
R
V
A
R
ATGGKT
L
V
L
D
V
G
E
D
A
S
V
T
A
-
A
A
N
E
V
R
A
-------------
R
Y
G
V
A
D
V
L
V
N
C
A
G
V
L
Q
RTL
P
P
G
---
E
-
L
A
Q
R
-
E
W
D
V
V
S
R
I
D
L
R
G
T
Y
L
C
C
A
A
F
G
A
P
-
M
A
D
R
R
-----
R
G
S
I
V
N
I
A
S
V
A
---
G
M
R
-
S
G
-
P
L
H
-
A
--
Y
G
P
A
K
A
G
V
I
S
L
T
E
T
L
A
G
E
W
G
P
K
G
V
R
V
N
C
--
V
S
P
G
F
T
Q
T
P
A
-------
L
----------
E
R
G
F
T
T
H
T
L
-
K
A
D
VL
R
D
A
A
A
----
L
G
H
I
---------
V
--
S
A
-
N
E
I
A
E
A
V
V
F
L
A
S
E
R
A
S
A
I
T
G
V
N
L
P
V
D
A
G
-------------
319
Blastp_CBE
71.48
35%
-38
- C7 -
-
1HDC
2
HSD_STREX
D:
[3-254]
--------------
L
S
G
K
T
V
I
I
T
G
-
G
A
R
G
L
----
G
A
E
A
A
R
Q
A
V
A
A
G
A
R
V
-
V
L
A
D
V-------------
L
-
D
E
E
G
A
A
T
A
R
E
------
L
------
G
D
A
A
R
Y
-
Q
H
L
D
V
T
I
E
E
D
W
Q
R
V
V
A
Y
A
R
E
E
F
G
S
V
D
G
L
V
N
N
A
G
I
-----
S
T
G
M
F
L
E
-
T
E
S
V
E
R
F
R
K
V
V
E
I
N
L
T
G
V
F
I
G
-
M
K
T
V
I
P
A
M
K
D
----
A
G
-
G
G
S
I
V
N
I
S
S
A
A
---
G
L
M
-
G
L
A
L
T
S
-
S
--
Y
G
A
S
K
W
G
V
R
G
L
S
K
L
A
A
V
E
L
G
T
D
R
I
R
V
N
S
--
V
H
P
G
M
T
Y
T
P
M
-------
T
---------
A
E
T
G
I
R
Q
--
G
-
E
G
N
--
Y
P
N
T
P
----
M
G
R
V
---------
G
---
E
P
G
E
I
A
G
A
V
V
K
L
L
S
D
T
S
S
Y
V
T
G
A
E
L
A
V
D
G
G
W
T
T
G
P
T
V
K
Y
V
M
G
Q
187
Blastp_CBE
70.85
37%
-24
- C7 -
-
5JLA
1
?
B:
[12-253]
---------
S
A
--
E
F
N
G
A
I
A
V
V
T
G
A
G
S
-----
G
I
G
R
A
C
A
E
L
L
S
R
S
G
A
N
V
-
I
V
A
D
--------------
R
-
D
I
E
A
A
T
R
V
A
R
A
T
G
G
K
T
L
V
L
D
V
G
E
D
A
S
V
T
A
-
A
A
N
E
V
R
A
-------------
R
Y
G
V
A
D
V
L
V
N
C
A
G
V
L
Q
R
TL
P
P
G
---
E
-
L
A
Q
R
-
E
W
D
V
V
S
R
I
D
L
R
G
T
Y
L
C
C
A
A
F
G
A
P
-
M
A
D
R
R
-----
R
G
S
I
V
N
I
A
S
V
A
---
G
M
R
-
S
G
-
P
L
H
-
A
--
Y
G
P
A
K
A
G
V
I
S
L
T
E
T
L
A
G
E
W
G
P
K
G
V
R
V
N
C
--
V
S
P
G
F
T
Q
T
P
A
-------
L
----------
E
R
G
F
T
T
H
T
L
-
K
A
D
V
L
R
D
A
A
A
----
L
G
H
I
---------
V
--
S
A
-
N
E
I
A
E
A
V
V
F
L
A
S
E
R
A
S
A
I
T
G
V
N
L
P
V
D
A
G
-------------
188
Blastp_CBE
69.89
37%
-29
- C7 -
-
5JLA
1
?
A:
[12-253]
---------
S
A
--
E
F
N
G
A
I
A
V
V
T
G
A
G
S
-----
G
I
G
R
A
C
A
E
L
L
S
R
S
G
A
N
V
-
I
V
A
D
--------------
R
-
D
I
E
A
A
T
R
V
A
R
A
T
G
G
K
T
L
V
L
D
V
G
E
D
A
S
V
T
A
-
A
A
N
E
V
R
A
-------------
R
Y
G
V
A
D
V
L
V
N
C
A
G
V
L
Q
R
TL
P
P
G
---
E
-
L
A
Q
R
-
E
W
D
V
V
S
R
I
D
L
R
G
T
Y
L
C
C
A
A
F
G
A
P
-
M
A
D
R
R
-----
R
G
S
I
V
N
I
A
S
V
A
---
G
M
R
-
S
G
-
P
L
H
-
A
--
Y
G
P
A
K
A
G
V
I
S
L
T
E
T
L
A
G
E
W
G
P
K
G
V
R
V
N
C
--
V
S
P
G
F
T
Q
T
P
A
-------
L
----------
E
R
G
F
T
--
T
L
-
K
A
D
V
L
R
D
A
A
A
----
L
G
H
I
---------
V
--
S
A
-
N
E
I
A
E
A
V
V
F
L
A
S
E
R
A
S
A
I
T
G
V
N
L
P
V
D
A
G
-------------
469
Blastp_CBE
68.72
36%
-82
- C7 -
-
5IG2
1
?
A:
[12-225]
--------------
F
D
G
K
V
A
V
I
T
G
A
G
S
-----
G
F
G
R
A
F
A
E
K
G
A
S
L
G
M
K
L
-
V
L
A
D
--------------
V
-
D
E
G
A
L
A
R
T
V
D
------
T
L
R
A
A
--
G
A
E
V
I
G
-
V
R
T
D
V
S
N
G
A
Q
V
Q
A
L
A
D
A
A
L
E
A
F
G
K
V
H
L
L
F
N
N
A
G
V
-
G
---
A
G
G
F
L
W
E
-
S
S
A
N
-
D
W
A
W
V
F
G
V
N
V
M
G
V
A
H
G
-
V
R
V
F
A
P
I
M
L
G
Q
N
E
A
A
----
H
I
V
N
T
A
S
V
A
---
G
L
L
--
S
P
P
S
M
G
I
--
Y
N
A
S
K
H
A
V
V
S
L
T
E
T
L
Y
H
D
L
R
N
A
G
G
E
V
G
C
S
L
L
C
P
A
F
V
P
T
G
--------
I
-----
A
D
--
A
E
R
V
R
P
E
A
L
R
N
E
A
Q
--
P
T
R
S
Q
----
L
-----------------------------------------------------------
467
Blastp_CBE
68.26
36%
-81
- C7 -
-
5IG2
1
?
C:
[12-225]
--------------
F
D
G
K
V
A
V
I
T
G
A
G
S
-----
G
F
G
R
A
F
A
E
K
G
A
S
L
G
M
K
L
-
V
L
A
D
--------------
V
-
D
E
G
A
L
A
R
T
V
D
------
T
L
R
A
A
--
G
A
E
V
I
G
-
V
R
T
D
V
S
N
G
A
Q
V
Q
A
L
A
D
A
A
L
E
A
F
G
K
V
H
L
L
F
N
N
A
G
V
-
G
---
A
G
G
F
L
W
E
-
S
S
A
N
-
D
W
A
W
V
F
G
V
N
V
M
G
V
A
H
G
-
V
R
V
F
A
P
I
M
L
G
Q
N
E
A
A
----
H
I
V
N
T
A
S
V
A
---
G
L
L
--
S
P
P
S
M
G
I
--
Y
N
A
S
K
H
A
V
V
S
L
T
E
T
L
Y
H
D
L
R
N
A
G
G
E
V
G
C
SL
L
C
P
A
F
V
P
T
G
--------
I
-----
A
D
--
A
E
R
V
R
P
E
A
L
R
N
E
A
Q
--
P
T
R
S
Q
----
L
-----------------------------------------------------------
468
Blastp_CBE
67.71
36%
-79
- C7 -
-
5IG2
1
?
B:
[12-225]
--------------
F
D
G
K
V
A
V
I
T
G
A
G
S
-----
G
F
G
R
A
F
A
E
K
G
A
S
L
G
M
K
L
-
V
L
A
D
--------------
V
-
D
E
G
A
L
A
R
T
V
D
------
T
L
R
A
A
--
G
A
E
V
I
G
-
V
R
T
D
V
S
N
G
A
Q
V
Q
A
L
A
D
A
A
L
E
A
F
G
K
V
H
L
L
F
N
N
A
G
V
-
G
---
A
G
G
F
L
W
E
-
S
S
A
N
-
D
W
A
W
V
F
G
V
N
V
M
G
V
A
H
G
-
V
R
V
F
A
P
I
M
L
G
Q
N
E
A
A
----
H
I
V
N
T
A
S
V
A
---
G
L
L
--
S
P
P
S
M
G
I
--
Y
N
A
S
K
H
A
V
V
S
L
T
E
T
L
Y
H
D
L
R
N
A
G
G
E
V
G
C
SL
L
C
P
A
F
V
P
T
G
--------
I
-----
A
D
--
A
E
R
V
R
P
E
A
L
R
N
E
A
Q
--
P
T
R
S
Q
----
L
-----------------------------------------------------------
344
Blastp_CBE
61.88
37%
-44
- C7 -
-
3QRW
2
ACT3_STRCO
A:
[25-214]
---------------
D
S
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
L
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
447
Blastp_CBE
61.56
36%
-42
- C7 -
-
1W4Z
5
ACT3_STRCO
A:
[23-214]
-------------
T
Q
D
S
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
P
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
346
Blastp_CBE
61.21
37%
-47
- C7 -
-
3CSD
3
ACT3_STRCO
A:
[26-214]
----------------
S
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
L
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
446
Blastp_CBE
61.09
36%
-15
- C7 -
-
1W4Z
5
ACT3_STRCO
B:
[16-221]
------
P
R
G
S
H
MA
T
Q
D
S
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
P
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
456
Blastp_CBE
60.99
37%
-45
- C7 -
-
1X7H
1
ACT3_STRCO
B:
[7-194]
-----------------
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
P
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
466
Blastp_CBE
60.93
36%
-41
- C7 -
-
4DC0
1
ACT3_STRCO
A:
[24-214]
--------------
Q
D
S
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
P
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
W
V
E
T
P
M
------------------------------------------------------------------------------------------------------
340
Blastp_CBE
60.88
37%
-49
- C7 -
-
2RHR
3
ACT3_STRCO
A:
[22-210]
----------------
S
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
L
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
449
Blastp_CBE
60.86
36%
-45
- C7 -
-
2RHC
2
ACT3_STRCO
A:
[21-210]
---------------
D
S
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
P
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
451
Blastp_CBE
60.78
36%
-42
- C7 -
-
2RH4
2
ACT3_STRCO
A:
[21-210]
---------------
D
S
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
P
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
457
Blastp_CBE
60.74
37%
-45
- C7 -
-
1X7H
1
ACT3_STRCO
A:
[7-194]
-----------------
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
P
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
459
Blastp_CBE
60.51
37%
-45
- C7 -
-
1X7G
1
ACT3_STRCO
A:
[7-194]
-----------------
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
P
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
342
Blastp_CBE
60.46
37%
-46
- C7 -
-
3RI3
3
ACT3_STRCO
A:
[26-214]
----------------
S
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
L
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
453
Blastp_CBE
60.27
36%
-39
- C7 -
-
4DBZ
1
ACT3_STRCO
A:
[25-214]
---------------
D
S
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
P
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
L
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
343
Blastp_CBE
60.24
37%
-20
- C7 -
-
3QRW
1
ACT3_STRCO
B:
[21-214]
-----------MA
T
Q
D
S
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
L
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
448
Blastp_CBE
60.18
36%
-13
- C7 -
-
2RHC
1
ACT3_STRCO
B:
[12-210]
------
P
R
G
S
H
MA
T
Q
D
S
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
P
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
455
Blastp_CBE
60.06
37%
-46
- C7 -
-
1XR3
2
ACT3_STRCO
A:
[7-194]
-----------------
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
P
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
445
Blastp_CBE
60.00
36%
-40
- C7 -
-
4DC1
1
ACT3_STRCO
A:
[24-214]
--------------
Q
D
S
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
P
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
444
Blastp_CBE
59.97
36%
-18
- C7 -
-
4DC1
1
ACT3_STRCO
B:
[21-214]
-----------MA
T
Q
D
S
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
P
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
465
Blastp_CBE
59.70
36%
-20
- C7 -
-
4DC0
1
ACT3_STRCO
B:
[21-214]
-----------MA
T
Q
D
S
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
P
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
W
V
E
T
P
M
------------------------------------------------------------------------------------------------------
450
Blastp_CBE
59.43
36%
-12
- C7 -
-
2RH4
1
ACT3_STRCO
B:
[12-210]
------
P
R
G
S
H
MA
T
Q
D
S
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
P
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
V
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------
452
Blastp_CBE
58.48
36%
-19
- C7 -
-
4DBZ
1
ACT3_STRCO
B:
[21-214]
-----------MA
T
Q
D
S
E
V
A
L
V
T
G
A
-----
T
S
G
I
G
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
R
--------------
G
-
E
E
G
L
R
T
T
L
K
E
------
L
---
R
E
A
G
V
E
A
D
G
-
R
T
C
D
V
R
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
P
V
D
V
L
V
N
N
A
G
R
P
G
---
G
G
A
T
A
E
L
-
A
D
E
L
--
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
-
T
K
Q
V
L
K
A
--
G
G
M
L
E
R
G
T
-
G
R
I
V
N
I
A
S
T
G
---
G
K
Q
-
G
L
V
H
A
A
-
P
--
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
--
V
C
P
G
F
V
E
T
P
M
------------------------------------------------------------------------------------------------------