@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : G8NX09_GRAMM: (2019-01-29 )
MSASPSLQVTAFEGNRCIASGPLASVAEKIKEVLARGEAASVLVFDDQTGSQVDLNLRTLSEAAQGMPTPLIAPEPLESRNAGRPRLGVVAREVTLLPRQWEWLGQQQGGASATLRKLVDQARRENAGEEKIRAAREALYRFMTAMAGNAPGYEEALRALFAGDVHRFSILTSDWATDVRKHVGKLAPAAFGYAPSPLDVVIPLTKREAVLRAFGTAEVQSIERITNGASGAGVFKVKANQVDYLLRIEGPPDGLRDPARQYACLKIAAEAGVAPRLVYADAESGVAVTDFIAPDSASVERSKADSLRRIVTAVRSLHDAPLFPELVDYLDGVDTLIRSCMETGILPKRAIETHRKFYGELAAAYPRKNLDLVSSHNDLNPGNVLFQKERVWLVDWESAFAADRYVDLAAIANFFTTEENEKELVLESYFGAALNDLHRARFFLMQQANRMFYAMVVLNFVAAAEPAIKLTAAGMKGIRWSEVRGEMARINTTETKVRFAGALLNEALLAFQSPRFSQAVAQVKGSSKRRGA
Atome Classification :
(20 SA)
---.........10........20........30........40........50....--....60..--.....-----------.-70-........80...----.....90.------.......100....------.----...110.......120-------------.........130.......140.....------------..150.......160....-...170.......180.......190.......200.......210....------...220.......230......--.240-------.----------.....-..-.250-.-..--....260.......270..-......----280------.--------.-------......290...-....300-.-..-......310......-.320---------------------....-.---------------.---------.--.330-......-----.340..----.-----.-----------.--.--------.-------350.......360...------.---...370.......380......---.-------390.......---400.......410...-----.---------.------------------.------------------.420....------..--.430..--------------.---------.----------...440.......450---.........460.......470.......480.....-----..490.......500.......510.......520.......530-----------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---MSASP
S
L
Q
V
T
A
FEG
N
R
C
IASG
P
L
A
S
V
A
E
K
I
K
E
V
L
ARGE
A
A
S
V
L
V
FDDQTG
S
Q
V
D
L
--
N
L
R
T
L
S
E
A
--AQGMP-----------T-PL-IAPEPLESRNAGR----P
R
L
G
V
V
A
R
------
E
V
TLLP
R
Q
W
-
E
W
L
G------Q----QQG
G
A
S
A
T
L
R
K
L
V
D
---------------
Q
A
R
RENA
G
E
E
K
I
R
A
A
R
E
A
L
Y
R
F
M
T
A
MA------------GNAP
G
Y
E
E
A
L
R
A
L
F
AGD
V
H
-
R
F
S
I
L
T
S
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W
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P
A
AFGYAPSP
L
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V
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PL
T
K
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A
V
L
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A
FG
T
------
A
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V
Q
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TNGASG
A
G
V
F
K
V
K--AN---------Q----------
V
D
Y
L
L
-
R
I-EGPP-D-G
L
--
R
D
P
A
R
Q
Y
A
C
L
K
I
A
A
EA-GV-A
P
R
L
V
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----AD-------A--------E-------SG
V
A
V
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D
F
IAPD-SAS
V
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---
R
-
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K
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LH-DAP----------------------L
F
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---------
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--
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ETG----I-----L-----------
P
--
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VSSHNDLNPG
N
V
L
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Q
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---
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-------
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DWESA---FAAD
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--------------
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----------
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-----
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AAAEP
A
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M
-----
A
RINTT
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K
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A
L
L
N
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A
L
L
A
FQSP
R
F
S
Q
A
V
A
Q
VKGSSKRRGA-----------------------------------------------------------------------
14
Fugue
76.91
18%
-20
- C8 -
-
2QG7
-
?
A:
[50-458]
-------------------------------------------------------
Y
P
I
--
T
E
S
N
L
R
I
------------------------------------------------------------------------------------------------------------------
L
E
G
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D
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L
L
K
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Y
V
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V
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------------
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-
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---------------------------------------------
N
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------
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S
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---------
Q
----------
A
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I
--
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---------------
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---
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G
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-------
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---
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------
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--
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--------------
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----------
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-----
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---
L
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N
Y
G
M
T
R
L
T
A
-----
S
C
L
P
I
F
R
S
K
V
----------------------------------------------------------------------------------------------------------
28
HHSearch
67.89
24%
6
- C8 -
-
3DXQ
-
?
B:
[4-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
A
R
A
K
L
A
A
I
P
M
L-----
A
G
Y
T
G
P
L
E
R
L
G
G
L
T
-
N
L
V
F
R
A
-------------------------
G
D
L
C
L
-
R
I
-
P
-----------
N
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A
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A
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G
S
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----------------------
A
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F
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---------------
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--
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----
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P
--------
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------
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---
A
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---
E
-------
R
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W
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D
W
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---
G
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-----
K
---------
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------------------
N
------------------
A
N
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------
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Y
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--------------
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---------
P
----------
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R
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V
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Y
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A
M
C
D
-----
L
L
W
T
L
W
G
L
I
Q
L
A
N
D
N
-
P
-
V
-----------
D
D
F
R
-------------
A
Y
A
D
G
R
F
A
R
C
-----
K
A
L
M
E
T
P
E
F
S
R
H
L
A
A
V
R
M
------------------------------------------------------------------------------
27
HHSearch
62.04
24%
8
- C- -
-
3DXQ
-
?
A:
[4-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
A
R
A
K
L
A
A
I
P
M
L-----
A
G
Y
T
G
P
L
E
R
L
G
G
L
T
-
N
L
V
F
R
A
-------------------------
G
D
L
C
L
-
R
I
-
P
G
K
-----
Y
--
I
N
R
A
N
E
A
V
A
A
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A
A
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A
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----
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-------
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--------
A
-------
T
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A
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A
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K
F
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K
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R
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P
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P
A
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A
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A
F
R
K
L
H
-
G
S
G
----------------------
A
V
F
P
F
R
---------------
F
---------
E
--
L
F
A
M
-
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D
D
Y
L
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-----
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L
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--
N
----
V
-----
T
-----------
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--
P
--------
A
-------
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V
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A
G
G
V
R
S
A
L
------
A
---
A
H
P
L
P
L
A
A
C
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C
D
P
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C
E
N
F
L
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T
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---
E
-------
R
M
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I
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W
E
Y
S
---
G
M
N
D
P
L
W
D
L
G
D
L
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V
E
G
-----
K
---------
F
------------------
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------------------
A
N
Q
D
E
E
L
M
------
R
A
--
Y
F
G
G
E
A
--------------
R
---------
P
----------
A
E
R
G
R
V
V
I
Y
K
A
M
C
D
-----
L
L
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T
L
W
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Q
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A
N
D
N
-
P
-
V
-----------
D
D
F
R
-------------
A
Y
A
D
G
R
F
A
R
C
-----
K
A
L
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T
P
E
F
S
R
H
L
A
A
V
R
M
------------------------------------------------------------------------------
41
HHSearch
60.07
19%
-81
* C8 *
-
2PPQ
-
KHSE_AGRFC
A:
[7-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
E
D
E
L
R
N
F
L
T
Q
Y
D
V
------
G
S
L
T
S
Y
K
G
I
A
E
----
N
S
N
F
L
L
H
--
T
T
---------
K
----------
D
P
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I
L
-
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L
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Y
E
K
-----
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--
N
D
L
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F
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A
A
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C
P
L
P
L
P
----
R
K
-------
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L
G
E
L
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-------
R
P
A
A
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F
L
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M
-
W
L
R
K
------
P
E
-
A
K
H
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V
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K
A
L
A
A
M
H
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L
A
S
----------------------
E
G
F
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-
I
---------------
K
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-------
N
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S
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-
W
K
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D
-----
K
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--
K
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L
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Y
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A
A
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W
----------
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L
P
A
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A
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D
N
V
F
F
L
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---
D
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F
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---
C
N
D
L
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A
Y
D
V
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C
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N
A
W
-----
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---------
F
EKDGAY------------
N
------------------
V
T
K
G
K
A
L
L
------
E
G
--
Y
Q
S
V
R
P
--------------
L
---------
S
E
---------
A
E
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E
A
L
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L
L
S
R
G
S
A
-----
L
R
F
F
L
T
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
54.69
18%
-4
- C8 -
-
2QG7
-
?
D:
[110-433]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
F
Q
I
I
N
G
G
-
T
-
N
I
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--
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SK-------
Q
----------
A
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I
-
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Y
G
P
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------
N
R
E
R
E
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I
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I
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-
N
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K
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----
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-------
T
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G
Y
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A
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R
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I
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N
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K
L
L
H
-
D
I
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----------------------
L
N
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N
-
L
YKELQVTQKVPGTRP
S
---------
F
--
L
W
N
T
-
I
W
K
Y
F
H
-----
L
L
N
E
E
R
----
K
-----
K
ICSFDAKANIL
K
--
L
--------
I
-------
D
F
D
V
L
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D
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V
E
V
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S
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------
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---
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D
-------
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I
D
F
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---
C
P
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E
R
A
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D
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H
F
N
E
Y
-----
A
GFNCDWDLT
P
------------------
S
------------------
K
E
E
E
Y
H
F
I
------
M
H
--
Y
L
G
T
D
D
--------------
E
ELI------
N
----------
Q
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E
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-----
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N
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G
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L
L
Q
G
M
H
S
------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
53.11
18%
-6
- C8 -
-
2QG7
-
?
E:
[110-433]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
F
Q
I
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N
G
-
I
T
-
N
I
L
I
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V
K
--
D
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SK-------
Q
----------
A
K
Y
L
I
-
R
L
-
Y
G
P
K
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D
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E
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--
I
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K
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I
L
Y
N
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-
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I
-
A
K
K
I
Y
V
----
F
F
-------
T
--------
N
---------
G
R
I
E
E
F
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G
Y
-
A
L
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D--
I
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Q
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A
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L
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L
L
H
-
D
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----------------------
L
N
E
N
-
L
YKELQVTQKVPGTRP
S
---------
F
--
L
W
N
T
-
I
W
K
Y
F
H
-----
L
L
N
E
E
R
----
K
-----
K
ICSFDAKANIL
K
--
L
--------
I
-------
D
F
D
V
L
R
D
S
I
V
E
V
E
S
L
C
------
K
---
R
E
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
T
V
GG-
D
-------
S
I
S
F
I
D
F
E
Y
S
---
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
E
Y
-----
A
GFNCDWDLT
P
------------------
S
------------------
K
E
E
E
Y
H
F
I
------
M
H
--
Y
L
G
T
D
D
--------------
E
ELI------
N
----------
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
-----
I
N
W
G
L
W
S
L
L
Q
G
M
H
S
------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
52.08
14%
-48
- C8 -
-
1ZYL
-
SRKA_ECOLI
A:
[10-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
H
P
D
T
I
M
D
A
L
F
E
H
G
I
------
R
V
D
S
G
L
T
P
L
-
N
S
Y
E
-
N
R
V
Y
Q
F
Q
--
D
E
D--------
R
----------
R
R
F
V
V
-
K
F
-
Y
R
P
E
-
R
W
T
A
--
D
Q
I
L
E
E
H
Q
F
A
L
Q
L
V
N
D
-
E
V
P
V
A
A
P
V
A
----
F
N
GQT
L
L
N
H
Q
--------
G
-------
F
Y
F
A
V
F
P
S
V
G
G
R
-
Q
F
E
A
D
------
N
-
I
D
Q
M
E
A
V
G
R
Y
L
G
R
M
H
-
Q
T
G
----------------------
R
K
Q
L
-
F
---------------
I
---------
H
R-
P
T
I
G
-
L
N
E
Y
L
I
E
P
R
K
-
L
F
E
D
A
T
----
L
-----
I
-----------
P
--
S
--------
G
-------
L
K
A
A
F
L
K
A
T
D
E
L
I
A
A
V
------
T
A
H
W
R
E
D
F
T
V
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
-----------
G
P
M
F
V
D
L
D
D
A
---
R
N
G
P
A
V
Q
D
L
W
M
L
L
N
G
D
-----
K
---------
A
E
-----------------
Q
------------------
R
M
Q
L
E
T
I
I
------
E
A
--
Y
E
E
F
S
E
--------------
F
---------
D
T---------
A
E
I
G
L
I
E
P
L
R
A
M
R
L
-----
V
Y
Y
L
A
W
L
M
R
R
W
A
--------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
51.97
20%
-4
- C8 -
-
1NW1
-
CKA2_CAEEL
B:
[74-399]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
L
R
I
S
R
I
K
G
G
M
S
-
N
M
L
F
L
C
R
--
L
S
EVYPPIRNE
P
----------
N
K
V
L
L
-
R
V
-
Y
F
N
P
-
E
-
T
E
--
S
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
-
H
L
-
G
P
K
L
Y
G
----
I
F
-------
S
-----------------
G
G
R
L
E
E
Y
I
P
S
R
-
P
L
S
C
H
E
--
I
-
S
L
-
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
-
Q
L
E
----------------------
V
P
I
W
-
K
EP-------------
D
---------
Y
--
L
C
E
A
-
L
Q
R
W
L
K
-----
Q
L
T
G
T
V
----
D
AE
H
R
F
D
-----------
L
--
P
--------
E
ECGVSSV
N
C
L
D
L
A
R
E
L
E
F
L
R
A
H
I
------
S
---
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
-----------
R
L
V
L
I
D
F
E
Y
A
---
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
-----
T
---------
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
D
Q
M
L
E
F
F
------
L
N
--
Y
L
R
E
Q
G
--------------
N
---------
T
RENE
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
-----
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
-----------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
51.06
15%
-8
- C8 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
----------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
K
E
L
L
S
---------------
T
M
D
L
D
T
D
A
N
T
I
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
------------
G
--------------------------
A
W
K
T
--------------------------
V
P
L
E
H
L
R
I
S
R
I
K
G
------
G
M
S
N
M
L
F
L
C
R
L
S
E
V
Y
P
---
P
I
R
--
N
E
---------
P
----------
N
K
V
L
L
-
R
V
-
Y
F
N
P
-
E
-
T
E
--
S
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
-
H
L
-
G
P
K
L
Y
------
G
-------
I
--------
F
-------
S
G
G
R
L
E
E
Y
I
P
S
R
-
P
L
S
C
H
---
E
-
I
S
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
-
Q
L
E
VPIWKEPD
Y
-------------
L
C
E
A
-
L
---------------
Q
---------
R
--
W
L
K
Q
-
L
T
G
T
V
D
AE
H
R
F
D
L
P
E
E
C
----
G
-----
V
-----------
S
--
S
--------
V
-------
N
C
L
D
L
A
R
E
L
E
F
L
R
A
H
I
------
S
---
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
---
R
--------
L
V
L
I
D
F
E
Y
A
---
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
-----
T
---------
I
------------------
D
------------------
Y
D
I
D
E
----------------
A
P
F
--------------
Y
---------
K
----------
I
Q
T
E
N
F
P
E
N
D
Q
M
L
E
-----
F
F
L
N
Y
L
R
E
Q
G
N
T
R
E
N
E
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
V
G
F
G
-------
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A
-------------------------------------------------------------------------
29
HHSearch
50.91
20%
1
- C8 -
-
1NW1
-
CKA2_CAEEL
A:
[74-399]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
L
R
I
S
R
I
K
G
G
M
S
-
N
M
L
F
L
C
R
--
L
S
EVYPPIRNE
P
----------
N
K
V
L
L
-
R
V
-
Y
F
N
P
-
E
-
T
E
--
S
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
-
H
L
-
G
P
K
L
Y
G
----
I
F
-------
S
-----------------
G
G
R
L
E
E
Y
I
P
S
R
-
P
L
S
C
H
E
--
I
-
S
L
-
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
-
Q
L
E
----------------------
V
P
I
W
-
K
EP-------------
D
---------
Y
--
L
C
E
A
-
L
Q
R
W
L
K
-----
Q
L
T
G
T
V
----
D
AE
H
R
F
D
-----------
L
--
P
--------
E
ECGVSSV
N
C
L
D
L
A
R
E
L
E
F
L
R
A
H
I
------
S
---
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
-----------
R
L
V
L
I
D
F
E
Y
A
---
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
-----
T
---------
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
D
Q
M
L
E
F
F
------
L
N
--
Y
L
R
E
Q
G
--------------
N
---------
T
RENE
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
-----
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
-----------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
50.52
19%
-38
- C3 -
-
1W3B
-
OGT1_HUMAN
B:
[1-388]
-----------------------
G
P
M
E
L
A
H
R
E
Y
Q
A
------------------
G
D
F
E
A
--
A
E
R
H
C
M
Q
L
--
W
R
Q
E
P
-----------
D
-
N
T
-
G
V
L
L
L
L
S
S
I
H
F
Q
C
----
R
R
L
D
R
S
A
H
------
F
S
T
L
A
I
K
Q
----------------------
N
P
L
L
A
E
A
Y
S
---------------
N
L
G
N
V
Y
K
E
R
G
Q
L
Q
E
A
I
E
H
Y
R
H
A
L
R
L
K
P
------------
D
F
I
D
G
Y
I
N
L
A
A
A
L
V
A
A
G
D
---------------
M
E
G
A
V
Q
A
Y
V
S
A
L
Q
Y
N
P
---
D
L
Y
C
V
R
S
D
L
G
N
L
L
K
A
L
G
--------------------------
R
L
E
--
E
A
---------
K
----------
A
C
Y
L
K
-
A
I
-
E
T
Q
P
-
N
-------
F
A
V
A
W
S
N
L
G
C
V
F
N
A
-
Q
G
-
E
I
W
L
A
I
----
H
H
-------
F
--------
E
-------
K
A
V
T
L
D
----
P
N
-
F
L
D
A
Y
---
I
-
N
L
-
G
N
V
L
K
E
-----------
A
R
----------------------
I
F
D
R
-
A
---------------
V
---------
A
--
A
Y
L
R
-
A
L
S
L
S
P
-----
N
---------------------------------------------------
H
A
V
V
H
G
N
L
A
C
V
Y
------
Y
---
E
Q
G
L
-------------------------------------
I
D
---
L
A
I
D
T
Y
R
R
A
I
E
L
Q
P
H
F
-----
P
---------
D
------------------
A
------------------
Y
C
N
L
A
N
A
L
------
K
E
KG
S
V
A
E
A
E
--------------
D
---------
C
----------
Y
N
T
A
L
R
L
C
P
T
H
A
D
S
-----
Y
R
K
A
L
E
V
F
P
-------------------
E
F
A
A
A
H
S
N
L
-----
A
S
V
L
Q
Q
Q
G
K
L
Q
E
A
L
M
H
Y
K
E
A
I
R
I
--
S
P
T
F
A
D
A
Y
S
N
M
G
N
T
L
K
E
M
Q
D
-----------------------------------------------------------------------
34
HHSearch
49.76
19%
10
- C8 -
-
4R78
2
?
A:
[38-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
S
V
E
Q
L
-
G
G
M
T
-
N
Q
N
Y
L
A
K
--
T
T
---------
N
----------
K
Q
Y
I
V
-
K
F
-
F
G
K
G
-
T
E
K
L
--
I
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
L
-
G
L
D
V
K
N
Y
L
-----
F
D
-------
I
--------
E
-------
A
G
I
K
V
N
E
Y
I
E
S
A
I
T
L
D
S
T
-----
S
I
-
K
T
K
F
D
K
I
A
P
I
L
Q
T
I
H
-
T
S
A
----------------------
K
E
L
R
G
E
---------------
F
---------
A
--
P
F
E
E
-
I
K
K
Y
E
S
-----
L
I
E
E
Q
I
----------------------
P
--
Y
--------
A
-------
N
Y
E
S
V
R
N
A
V
F
S
L
E
K
R
L
------
A
---
D
L
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
S
P
Q--
G
-------
R
L
Y
L
I
D
W
E
Y
S
---
S
M
N
D
P
M
W
D
L
A
A
L
F
L
E
S
-----
E
---------
F
------------------
T
------------------
S
Q
E
E
E
T
F
L
------
S
H
--
Y
E
S
D
Q
T
------------------------
P
----------
V
S
H
E
K
I
A
I
Y
K
I
L
Q
D
-----
T
I
W
S
L
W
T
V
Y
K
E
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
49.63
19%
12
- C8 -
-
4R7B
-
?
A:
[38-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
S
V
E
Q
L
-
G
G
M
T
-
N
Q
N
Y
L
A
K
--
T
T
---------
N
----------
K
Q
Y
I
V
-
K
F
-
F
G
K
G
-
T
E
K
L
--
I
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
L
-
G
L
D
V
K
N
Y
L
-----
F
D
-------
I
--------
E
-------
A
G
I
K
V
N
E
Y
I
E
S
A
I
T
L
D
S
T
-----
S
I
-
K
T
K
F
D
K
I
A
P
I
L
Q
T
I
H
-
T
S
A
----------------------
K
E
L
R
G
E
---------------
F
---------
A
--
P
F
E
E
-
I
K
K
Y
E
S
-----
L
I
E
E
Q
I
----------------------
P
--
Y
--------
A
-------
N
Y
E
S
V
R
N
A
V
F
S
L
E
K
R
L
------
A
---
D
L
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
S
P
Q--
G
-------
R
L
Y
L
I
D
W
E
Y
S
---
S
M
N
D
P
M
W
D
L
A
A
L
F
L
E
S
-----
E
---------
F
------------------
T
------------------
S
Q
E
E
E
T
F
L
------
S
H
--
Y
E
S
D
Q
T
------------------------
P
----------
V
S
H
E
K
I
A
I
Y
K
I
L
Q
D
-----
T
I
W
S
L
W
T
V
Y
K
E
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
48.05
21%
36
- C2 -
-
4M1K
1
?
A:
[6-688]
EYD
L
K
R
L
R
N
I
G
I
A
A
H
I
D
-----
A
G
-
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
A
A
V
T
T
C
F
W
K
D
H
R
I
N
I
I
D
T
PG
H
V
D
F
T
I
E
V
--
E
R
S
M
R
V
LD
G
A
I
V
V
F
DS
S
-
Q
G
-
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
MDKTGA
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
ARPVVM
Q
----
L
P
I
G
R
E
D
T
F
S
G
I
I
D
VLRM
K
A
Y
T
Y
GNDLGT
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
-
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
--
I
P
P
I
K
G
T
-----
T
P
E
------
G
E
V
V
E
I
H
P
D
P
N
G
P
L
A
A
L
A
F
K
I
M
--
A
D
-------------------------------
P
Y
-
V
-
G
--------
R
L
T
F
I
R
V
Y
S
G
T
-
L
T
-
S
G
S
Y
V
Y
NTTK
G
R
-------
K
--------
E
-------
R
V
A
R
L
L
R
M
H
A
N
H
-
R
E
E
V
E
---
E
-
L
K
-
A
G
D
L
G
A
V
V
G
L
K
E
T
I
T
-
G
D
T
----------------------
L
V
G
E
-
D
---------------
A
---------
P
RV
I
L
E
S
-
I
E
V
P
-
E
-----
P
V
I
D
V
A
----
I
-----
E
-----------
P
--
K
--------
T
-------
K
-
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
------
E
---
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
---
E
-------
L
H
L
E
I
I
V
D
R
L
K
RE
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
-----
T
I
T
K
P
-----
V
------------------
D
------------------
V
E
G
K
F
I
R
L
TGG
R
G
Q
Y
G
--
H
V
K
I
K
V
--------------
E
---------
P
----------
L
P
R
G
S
G
F
E
F
V
N
A
I
V
GGVIP
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
-----
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
RGQIL
G
M
E
P
R
GN
A
Q
V
I
R
A
F
V
P
LAEMFG
Y
A
T
D
L
R
S
K
T
Q
GR
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
LI
37
HHSearch
47.95
16%
-6
- C8 -
-
5FUT
9
CHKA_HUMAN
A:
[30-352]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
F
H
I
S
V
I
R
G
G
L
S
-
N
M
L
F
Q
C
S
--
L
P
---------
D
TTATLGDEP-
R
K
V
L
L
-
R
L
-
Y
G
-------G
A
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
-
S
L
-
G
P
K
L
Y
G
----
I
F
-------
P
-----------------
Q
G
R
L
E
Q
F
I
P
S
R
-
R
L
D
T
E
E--
L
-
S
L
-
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
-
G
M
K
----------------------
M
P
F
N
-
K
---------------
E
PK-------
W
--
L
F
G
T
-
M
E
K
Y
L
K
-----
E
V
L
R
I
K
----
F
-----
T
-----------
E
--
E
S
R
I
K
K
L
H
K
L
-------
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
L
L
------
E
---
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
E
---
G
RENSEKQ
K
L
M
L
I
D
F
E
Y
S
---
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
W
-----
M
---------
Y
------------------
D
YSYEKYPF
F
R
A
N
IRKYPT
K
K
Q
Q
L
H
F
I
------
S
S
--
Y
L
P
A
F
Q
NDFENLS
T
E
E
K
S
I
I
K
---------
E
----------
E
M
L
L
E
V
N
R
F
A
L
A
S
H
-----
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
47.28
14%
-3
- C8 -
-
3C5I
3
?
D:
[13-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
L
Y
I
K
K
I
C
L
E
K
V
P
EWNHFT
E
D
N
L
R
V
K
Q
I
L
--
L
T
-
N
Q
L
F
E
V
G
--
L
K
---------
E
E
T
A
N
N
Y
NSIR
T
R
V
L
F
-
R
I
-
Y
G
K
H
-
V
D
E
L
--
Y
N
T
I
S
E
F
E
V
Y
K
T
M
S
K
Y
-
K
I
-
A
P
Q
L
L
N
----
T
F
------------------------
N
G
G
R
I
E
E
W
L
Y
G
D
-
P
L
R
I
D
D
--
L
-
K
N
-
P
T
I
L
I
G
I
A
N
V
L
G
K
F
H
-
T
L
S
----------------------
R
K
R
H
-
L
---------------
P
EHWDRTP--
C
--
I
F
K
M
-
M
E
K
W
K
N
-----
Q
L
F
K
Y
K
----
N
-----
I
-----------
E
KY
N
--------
C
-------
D
I
H
K
Y
I
K
E
S
D
K
F
I
K
F
M
K
V
Y
S
KS
D
---
N
L
A
N
T
I
V
F
C
H
N
D
L
Q
E
N
N
I
I
N
T
N
---
K
-------
C
L
R
L
I
D
F
E
Y
S
---
G
F
N
F
L
A
T
D
I
A
N
F
F
I
E
T
-----
S
---------
I
DYSVSSYPF
F
E
I
D
KKKYI
S
------------------
Y
E
N
R
K
L
F
I
------
T
A
--
Y
L
S
N
Y
L
--------------
D
KVVPT
P
K
L
I
D
----------
E
I
L
E
A
V
E
V
Q
A
L
G
A
H
-----
L
L
W
G
F
W
S
I
I
R
G
Y
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
47.00
20%
14
* C7 *
-
5THY
1
?
A:
[19-405]
---
Y
F
Q
S
N
A
L
P
P
D
F
L
L
D
------------
P
V
E
V
S
Q
Q
L
A
P
S
L
T
E
L
V
T
L
L
D
N
A
R
T
S
E
I
G
T
--
Q
L
E
E
L
S
V
D
Y
I
V
Q
G
L
L
-----------
Q
M
G
W
S
Y
Q
P
T
E
S
F
D
L
D
A
A
A
----
Q
C
L
G
V
V
P
T
------
Q
V
R
L
F
E
R
L
L
-
Q
I
L
A
------
E
V
GI
L
Q
S
N
Q
Q
Q
W
Q
V
Q
K
-
T
A
---------------
Q
K
V
N
P
S
K
Q
S
Q
S
L
L
S
Q
Y
P
D
E
A
A
T
L
T
L
L
E
------------
R
C
A
S
Q
L
S
G
V
L
R
--------------------------
G
E
I
D
P
V
Q
L
V
F
P
Q
G
D
L
T
T
A
T
Q
L
Y
K
D
S
A
V
A
K
V
-------------------------------
M
-
N
T
---------
I
----------
V
E
K
V
I
M
K
A
M
E
K
L
P
---------
P
S
R
G
I
R
L
L
E
I
G
A
G
T
-
G
G
-
T
T
S
Y
I
L
----
P
H
-------
L
--------
N
-------
P
N
Q
--
T
E
Y
I
F
T
D
-
I
G
A
L
F
---
T
-
S
K
-
A
Q
E
K
F
Q
D
Y
R
F
L
G
Y
Q
T
L
D
I
E
----------------------
V
D
P
S
-
S
---------------
Q
---------
G
--
F
E
S
H
R
Y
D
V
I
I
A
A
----
N
V
L
H
A
T
----
T
-----
S
-----------
L
--
K
--------
Q
-------
T
L
S
H
V
R
Q
L
------------------------------
L
A
P
G
G
I
L
V
L
Y
---
E
-------
A
T
------------
T
R
S
R
W
V
D
L
I
---------------------------------------------------------------
F
G
L
L
------
E
G
--
W
W
--
K
F
--------------
T
---------
D
----------
Y
E
L
R
P
D
Y
P
L
L
N
R
E
Q
-----
W
K
K
V
L
S
E
T
G
F
T
--------------
Q
V
V
T
L
P
E
V
E
G
M
------------------
A
E
A
L
S
Q
Q
T
V
I
V
A
Q
A
A
S
----------------------------------------------------------------------------------------
44
HHSearch
46.89
17%
-25
- C8 -
-
5IGI
3
?
A:
[7-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
T
S
Q
L
Y
A
L
A
A
R
H
G
L
------
K
L
H
G
P
L
T
V
N
E
L
G
L
D
-
Y
R
I
V
I
A
T
--
V
D
D--------
G
----------
R
R
W
V
L
-
R
I
-
P
R
R
A
-
E
-
V
S
--
A
K
V
E
P
E
A
R
V
L
A
M
L
K
N
R
L
P
F
A
V
P
D
W
R
V
----
A
N
-------
A
--------
E
L
V
A
Y
PML
E
D
S
T
A
-
V
I
Q
P
G
S
-
S
T
P
D
W
VVP
Q
-
D
S
-
E
V
F
A
E
S
F
A
T
A
L
A
A
L
H
-
A
V
P
----------------------
I
S
A
A
-
V
---------------
D
A
GMLIRT
P
T
Q
--
A
R
Q
K
-
V
A
D
D
V
D
-----
R
V
R
R
E
F
----
V
-----
V
-----------
N
--
D
--------
K
-------
R
L
H
R
W
Q
R
W
---
L
D
D
D
-------
S
---
S
W
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T--
E
R------
V
S
G
M
I
D
W
S
E
A
---
R
V
D
D
P
A
I
D
M
A
A
H
L
M
V
F
-----
G
-----------------------------------------------
E
E
G
L
A
K
L
L
------
L
T
--
Y
E
A
A
G
G
--------------
R
V
W
-------
P
----------
R
L
A
H
H
I
A
E
R
L
A
F
G
A
-----
V
T
Y
A
L
F
A
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
46.77
16%
-4
- C8 -
-
5FTG
10
CHKA_HUMAN
A:
[30-352]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
F
H
I
S
V
I
R
G
G
L
S
-
N
M
L
F
Q
C
S
--
L
P
---------
D
TTATLGDEP-
R
K
V
L
L
-
R
L
-
Y
G
---------
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
-
S
L
-
G
P
K
L
Y
G
----
I
F
-------
P
-----------------
Q
G
R
L
E
Q
F
I
P
S
R
-
R
L
D
T
E
E--
L
-
S
L
-
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
-
G
M
K
----------------------
M
P
F
N
-
K
---------------
E
PK-------
W
--
L
F
G
T
-
M
E
K
Y
L
K
-----
E
V
L
R
I
K
----
F
-----
T
-----------
E
--
E
S
R
I
K
K
L
H
K
L
-------
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
L
L
------
E
---
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
E
---
G
RENSEKQ
K
L
M
L
I
D
F
E
Y
S
---
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
W
-----
M
---------
Y
------------------
D
YSYEKYPF
F
R
A
N
IRKYPT
K
K
Q
Q
L
H
F
I
------
S
S
--
Y
L
P
A
F
Q
NDFENLS
T
E
E
K
S
I
I
K
---------
E
----------
E
M
L
L
E
V
N
R
F
A
L
A
S
H
-----
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
46.50
17%
-28
- C8 -
-
5IGH
-
?
A:
[7-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
T
S
Q
L
Y
A
L
A
A
R
H
G
L
------
K
L
H
G
P
L
T
V
N
E
L
G
L
D
-
Y
R
I
V
I
A
T
--
V
D
D--------
G
----------
R
R
W
V
L
-
R
I
-
P
R
R
A
-
E
-
V
S
--
A
K
V
E
P
E
A
R
V
L
A
M
L
K
N
R
L
P
F
A
V
P
D
W
R
V
----
A
N
-------
A
--------
E
L
V
A
Y
P
ML
E
D
S
T
A
M
V
I
Q
P
G
S
-
S
T
P
D
W
V
V
P
Q
-
D
S
-
E
V
F
A
E
S
F
A
T
A
L
A
A
L
H
-
A
V
P
----------------------
I
S
A
A
-
V
---------------
D
A
G
M
L
I
R
T
P
T
Q
--
A
R
Q
K
-
V
A
D
D
V
D
-----
R
V
R
R
E
F
----
V
-----
V
-----------
N
--
D
--------
K
-------
R
L
H
R
W
Q
R
W
---
L
D
D
D
-------
S
---
S
W
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T--
E
R------
V
S
G
M
I
D
W
S
E
A
---
R
V
D
D
P
A
I
D
M
A
A
H
L
M
V
F
-----
G
-----------------------------------------------
E
E
G
L
A
K
L
L
------
L
T
--
Y
E
A
A
G
G
--------------
R
V
W
-------
P
----------
R
L
A
H
H
I
A
E
R
L
A
F
G
A
-----
V
T
Y
A
L
F
A
L
D
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