@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H3ZD64_9ALTE: (2019-01-29 )
MAQPLSTAADIAQQDAVRQLCEQLEFFQQHPPLEIRPLAAGQSNLNYYLRTARGEYVLRRYARQLGVCRQQEFRCQQAAAAKQIAATPLLLHNHQQLLISEFLPGGEPLKLTDSRLSLLADTLGILHNLRVQTPLLQPASYLRQLLAQGQQITLQPAANLFAALQRCAEQLAGMATDLVLCHLDLHADNLLWNGNKIWLLDFEYSQLCDNSFDLAAIMLHFELTAAQQQRLLRQYSAQRRYPDRHTAERLAATLPQRLQLAKCLYSGFCWLWYQATPALHHRANSWQQRLQQLLQSETTEPFR
Atome Classification :
(20 SA)
-------------------------.........10..-......20..-.--..----..----.30........40..--.....-.50-..---------.----------......-60.-..--------.--.-.--.-..70........80.-...-.-------...90----..---..----------.-.-...100....----...110-.-.------.---..----.-...120....-..---.----.-------------------------130.-.-----------------.-----------.---------------.----..-------------------140-----------------------......-.----------150--------.-----.--------------.--------.-------.-----..160.-----------...--...170-----...---....-.---180.......190-----.-.-------..---...200........210....-...---220--------..------------------.-.....230...-.....240----.......250...-....-.260.......270...-....280---....--.....290.......300.--------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------MAQP
L
S
T
A
A
D
I
A
Q
-
Q
D
A
V
R
Q
L
C
E
Q
-
L
--
E
F
----
F
Q
----QHPP
L
E
I
R
PLAAGQS--N
L
N
Y
Y
-
L
R--TA---------R----------
G
E
Y
V
L
R
-
R
-
Y
-
A
R
--------
Q
--L-G--
V
-
C
R
Q
Q
E
F
R
C
Q
Q
A
A
A
A
K
-
Q
IA-A-------T
P
L
L
-----LH---N
H
----------
Q
-
Q
-
L
L
I
S
E
FLPGG----E
P
L
K
---L-
T
------
D
---
S
R
----
L
-
S
L
L
A
-
D
T
L
G
I
-
L
H
---N----L-------------------------RVQT-P-----------------L-----------L---------------
Q
----
P
A
-------------------
S
Y
L
-----------------------
R
Q
L
L
AQ-G----------
Q
Q
I
--------
T
-----L--------------
Q
--------
P
-------
A
-----
A
N
L
F
A
A
-----------
L
Q
R
--
C
A
E
Q
L
------
A
G
M
---
A
T
D
L
-
V
---
L
C
H
L
D
LHAD
N
L
L
W-----N-G-------
N
K
---
I
W
L
L
-DF
E
Y
S
Q
LCDNS
F
D
L
A
A
-
I
M
L
---
H
F
---------EL------------------
T
-
A
A
Q
Q
Q
R
L
-
L
R
Q
-
Y
S
A
QRRYP----D
R
H
T
A
E
R
L
A
-
A
T
L
-
P
Q
R
L
-
Q
L
A
K
C
L
Y
SG
F
C
W
L
W
YQA-T
P
A
L
H
-----
H
R
A
N
--
S
W
Q
Q
R
L
Q
Q
L
L
Q
SETTEPFR--------------------
40
HHSearch
77.43
17%
-2
- C3 -
-
4R78
2
?
A:
[18-301]
----------------------------------
G
S
H
M
-
E
K
I
I
K
E
K
I
S
S
L
L
--
S
Q
----
E
E
----
E
V
L
--
S
V
E
Q
L
-
G
G
M
T
--
N
Q
N
Y
L
-
A
K
--
T
T
---------
N
----------
K
Q
Y
I
V
K
-
F
-
F
G
K
G
T-------
E
--
K
-
L
--
I
-
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
L
-
G
L
D
V
K
-------
N
--
Y
-----
L
F
---
D
I
----------
E
A
G
-
I
K
V
N
E
Y
I
E
S
A
I
---
T
L
D
S
---
T
S
I
------
K
---
T
K
----
F
-
D
K
I
A
-
P
I
L
Q
T
-
I
H
---
T
----
S
-------------------------
A
K
E
L
-
R
-----------------
G
E
----------
F
---------------
A
----
P
F
-------------------
E
E
I
-----------------------
K
K
Y
E
S
L
-
I
----------
E
E
Q
--------
I
-----
P
Y-------------
A
--------
N
-------
Y
-----
E
S
V
R
N
A
-----------
V
F
S
--
L
E
K
R
L
------
A
D
L
---
G
V
D
R
-
K
---
S
C
H
I
D
L
V
P
E
N
F
I
E
-----
S
-
P
Q------
G
R
---
L
Y
L
I
-
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
-
L
F
L
---
E
S
---------
E
F
------------------
T
-
S
Q
E
E
E
T
F
-
L
S
H
-
Y
E
S
D
Q
T
P
----------------
V
S
-
H
E
K
I
-
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
-
K
E
E
Q
G
EDFGD
Y
G
V
N
--
R
Y
Q
R
A
V
K
G
L
A
-----------------------------
39
HHSearch
77.39
17%
-2
* C3 *
-
4R7B
-
?
A:
[18-301]
----------------------------------
G
S
H
M
-
E
K
I
I
K
E
K
I
S
S
L
L
--
S
Q
----
E
E
----
E
V
L
--
S
V
E
Q
L
-
G
G
M
T
--
N
Q
N
Y
L
-
A
K
--
T
T
---------
N
----------
K
Q
Y
I
V
K
-
F
-
F
G
K
G
T-------
E
--
K
-
L
--
I
-
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
L
-
G
L
D
V
K
-------
N
--
Y
-----
L
F
---
D
I
----------
E
A
G
-
I
K
V
N
E
Y
I
E
S
A
I
---
T
L
D
S
---
T
S
I
------
K
---
T
K
----
F
-
D
K
I
A
-
P
I
L
Q
T
-
I
H
---
T
----
S
-------------------------
A
K
E
L
-
R
-----------------
G
E----------
F
---------------
A
----
P
F
-------------------
E
E
I
-----------------------
K
K
Y
E
S
L
-
I
----------
E
E
Q
--------
I
-----
P
Y-------------
A
--------
N
-------
Y
-----
E
S
V
R
N
A
-----------
V
F
S
--
L
E
K
R
L
------
A
D
L
---
G
V
D
R
-
K
---
S
C
H
I
D
L
V
P
E
N
F
I
E
-----
S
-
P
Q------
G
R
---
L
Y
L
I
-
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
-
L
F
L
---
E
S
---------
E
F
------------------
T
-
S
Q
E
E
E
T
F
-
L
S
H
-
Y
E
S
D
Q
T
P
----------------
V
S
-
H
E
K
I
-
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
-
K
E
E
Q
G
EDFGD
Y
G
V
N
--
R
Y
Q
R
A
V
K
G
L
A
-----------------------------
30
Fugue
70.24
16%
-27
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
---------------------------
T
D
I
T
--------
E
D
E
L
R
N
F
L
T
Q
-
Y
--
D
V
----
G
----------
S
L
T
S
Y
K
G
I
A
E
--
N
S
N
F
L
-
L
H
--
T
T
---------
K
----------
D
P
L
I
L
T
-
L
-
Y
-
E
K
KN
D
L
P
F
F
L
G
--
L
M
Q
--
H
-
L
A
A
K
G
L
S
C
P
L
P
L
P
R
K
-
D
-
G
-
E
-------
L
L
G
E
-----
L
S
---
G
R
----------
P
-
A
-
A
L
I
S
F
--
L
E
G
M
---
W
L
R
K
---
P
-
E
------
A
---
K
H
----
C
-
R
E
V
G
-
K
A
L
A
A
M
H
L
A
S
E
G
----
F
-------------------------
E
I
K
R
-
P
-----------------
N
-----------
A
---------------
L
----
S
V
-------------------
D
G
W
-----------------------
K
V
L
W
D
K
-
S
----------
E
E
R
--------
A
-----
D
--------------
E
--------
V
-------
E
-----
K
G
L
R
E
E
-----------
I
R
P
--
E
I
D
Y
L
------
A
A
H
---
W
P
K
D
-
L
PAG
V
I
H
A
D
L
F
Q
D
N
V
F
F
-----
L
-
G
-------
D
E
---
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
-
C
L
N
---
A
W
CFEKDG---
A
Y
------------------
N
-
V
T
K
G
K
A
L
-
L
E
G
-
Y
Q
S
V
R
P
L
S
-------
E
A
E
L
E
A
-
L
P
L
-
L
S
R
G
-
S
A
L
R
F
F
L
T
R
L
Y
D
W
L
T
T
P
-
A
G
A
L
V
-----
V
K
K
D
P
L
E
Y
L
R
K
L
R
F
H
R
T
I
A
N
V
A
E
Y
G
LA------------------
52
HHSearch
70.10
17%
-32
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[7-284]
------------------------------------
I
T
-
E
D
E
L
R
N
F
L
T
Q
-
Y
--
D
V
----
G
-----
S
L
T
--
S
Y
K
G
I
A
E
-----
N
S
N
F
L
-
L
H
--
T
T
---------
K
----------
D
P
L
I
L
T
-
L
-
Y
E
K
--------------
K
--
N
-
D
L
P
F
F
L
G
L
M
Q
H
L
A
A
K
-
G
L
S
C
P
-------
L
--
P
-----
L
P
---
R
K
DGEL
L
G
E
L
SG
R
-
P
-
A
A
L
I
S
F
L
E
G
M
----
W
L
R
K
---
P
-
E
------
A
---
K
H
----
C
-
R
E
V
G
-
K
A
L
A
A
-
M
H
---
L
----
A
-------------------------
S
E
G
F
-
E
-----------------
I
-----------
K
---------------
R
P
NAL
S
V
-------------------
D
G
W
-----------------------
K
V
L
W
D
K
-
S
----------
E
E
R
--------
A
-----
D
--------------
E
--------
V
-------
E
-----
K
G
L
R
E
E
-----------
I
R
P
--
E
I
D
Y
L
A
A
H
---
W
P
K
---
D
L
P
A
-
G
---
V
I
H
A
D
L
F
Q
D
N
V
F
F
-----
L
-
G
D------
E
L
---
S
G
L
I
-
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
-
C
L
N
---
A
W
---------
C
F
EKDGAY------------
N
-
V
T
K
G
K
A
L
-
L
E
G
-
Y
Q
S
V
R
P
L
S
--------------
E
A
E
-
L
E
A
L
-
P
L
L
S
R
G
S
A
L
R
F
F
L
T
R
L
Y
-
D
W
-----------------------------------------------------
58
HHSearch
69.72
17%
-4
- C3 -
-
5FTG
11
CHKA_HUMAN
A:
[8-351]
-------------------------------------
T
-
R
R
R
A
Y
L
W
C
K
E
F
L
--
P
G
A---
W
R
GLRE
D
E
F
--
H
I
S
V
I
R
G
G
L
S
--
N
M
L
F
Q
-
C
S
--
L
P
---------
D
TTATLGDEP-
R
K
V
L
L
R
-
L
-
Y
-
G
-----------------
E
-
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
-
S
L
G
-
P
-------
K
--
L
-----
Y
G
---
I
F
----------
P
-
Q
-
G
R
L
E
Q
F
I
P
S
R
----
R
L
D
T
EEL
S
-
L
------
P
---
D
I
----
S
-
A
E
I
A
-
E
K
M
A
T
-
F
H
---
G
----
M
-------------------------
K
M
P
F
-
N
-----------------
K
-----------
E
PK-------------
W
----
L
F
-------------------
G
T
M
-----------------------
E
K
Y
L
K
E
-
V
----------
L
R
I
--------
K
-----
F
TE
E
S
R
I
--------
K
--------
K
-------
L
H
K
L
L
S
Y
N
L
P
L
E
-----------
L
E
N
--
L
R
S
L
L
------
E
S
T
---
P
S
P
V
-
V
---
F
C
H
N
D
C
Q
E
G
N
I
L
L
-----
L
-
E
GRENSEK
Q
K
---
L
M
L
I
-
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
-
H
F
C
---
E
W
---------
M
Y
DYSYEKYPF
F
R
A
N
IRKYP
T
-
K
K
Q
Q
L
H
F
-
I
S
S
-
Y
L
P
A
F
Q
N
D
FENL
S
T
E
E
K
S
I
I
K
-
E
E
M
-
L
L
E
V
-
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
-
Q
A
K
I
---------------------------------------------------
59
HHSearch
68.44
17%
-2
- C3 -
-
5FUT
10
CHKA_HUMAN
A:
[8-351]
-------------------------------------
T
-
R
R
R
A
Y
L
W
C
K
E
F
L
--
P
G
A---
W
R
GLRE
D
E
F
--
H
I
S
V
I
R
G
G
L
S
--
N
M
L
F
Q
-
C
S
--
L
P
---------
D
TTATLGDEP-
R
K
V
L
L
R
-
L
-
Y
-
G
---------------G
A
E
-
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
-
S
L
G
-
P
-------
K
--
L
-----
Y
G
---
I
F
----------
P
-
Q
-
G
R
L
E
Q
F
I
P
S
R
----
R
L
D
T
EEL
S
-
L
------
P
---
D
I
----
S
-
A
E
I
A
-
E
K
M
A
T
-
F
H
---
G
----
M
-------------------------
K
M
P
F
-
N
-----------------
K
-----------
E
PK-------------
W
----
L
F
-------------------
G
T
M
-----------------------
E
K
Y
L
K
E
-
V
----------
L
R
I
--------
K
-----
F
TE
E
S
R
I
--------
K
--------
K
-------
L
H
K
L
L
S
Y
N
L
P
L
E
-----------
L
E
N
--
L
R
S
L
L
------
E
S
T
---
P
S
P
V
-
V
---
F
C
H
N
D
C
Q
E
G
N
I
L
L
-----
L
-
E
GRENSEK
Q
K
---
L
M
L
I
-
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
-
H
F
C
---
E
W
---------
M
Y
DYSYEKYPF
F
R
A
N
IRKYP
T
-
K
K
Q
Q
L
H
F
-
I
S
S
-
Y
L
P
A
F
Q
N
D
FENL
S
T
E
E
K
S
I
I
K
-
E
E
M
-
L
L
E
V
-
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
-
Q
A
K
I
---------------------------------------------------
44
HHSearch
66.22
17%
-21
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[53-397]
---------------------------------------
K
E
R
A
H
M
L
C
A
R
-
F
L-
G
G
A---
W
K
TVPL
E
H
L
--
R
I
S
R
I
K
G
G
M
S
--
N
M
L
F
L
-
C
R
--
L
S
EVYPPIRNE
P
----------
N
K
V
L
L
R
-
V
-
Y
F
N
P
--------
E
--
T
-
E
--
S
-
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
-
H
L
G
-
P
-------
K
--
L
-----
Y
G
---
I
F
----------
S
-
G
-
G
R
L
E
E
Y
I
P
S
R
----
P
L
S
C
H
E
I
S
-
L
------
A
---
H
M
----
S
-
T
K
I
A
-
K
R
V
A
K
-
V
H
---
Q
----
L
-------------------------
E
V
P
I
-
W
-----------------
K
-----------
E
PD-------------
Y
----
L
C
-------------------
E
A
L
-----------------------
Q
R
W
L
K
Q
-
L
----------
T
G
T
--------
V
-----
D
AE
H
R
F
D
L
-------
P
EECGVSSV
N
-------
C
-----
L
D
L
A
R
E
-----------
L
E
F
--
L
R
A
H
I
------
S
L
S
---
K
S
P
V
-
T
---
F
C
H
N
D
L
Q
E
G
N
I
L
L
-----
P
-
K
--------
R
---
L
V
L
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
-
H
F
I
---
E
W
---------
T
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
-
N
D
Q
M
L
E
F
-
F
L
N
-
Y
L
R
E
Q
G
N
T
----
R
E
N
E
L
Y
K
K
S
-
E
D
L
-
V
Q
E
T
-
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
-
Q
V
E
L
---------------------------------------------------
43
HHSearch
65.42
17%
-21
- C3 -
-
1NW1
-
CKA2_CAEEL
B:
[53-397]
---------------------------------------
K
E
R
A
H
M
L
C
A
R
-
F
L
-
G
G
A---
W
K
TVPL
E
H
L
--
R
I
S
R
I
K
G
G
M
S
--
N
M
L
F
L
-
C
R
--
L
S
EVYPPIRNE
P
----------
N
K
V
L
L
R
-
V
-
Y
F
N
P
--------
E
--
T
-
E
--
S
-
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
-
H
L
G
-
P
-------
K
--
L
-----
Y
G
---
I
F
----------
S
-
G
-
G
R
L
E
E
Y
I
P
S
R
----
P
L
S
C
H
E
I
S
-
L
------
A
---
H
M
----
S
-
T
K
I
A
-
K
R
V
A
K
-
V
H
---
Q
----
L
-------------------------
E
V
P
I
-
W
-----------------
K
-----------
E
PD-------------
Y
----
L
C
-------------------
E
A
L
-----------------------
Q
R
W
L
K
Q
-
L
----------
T
G
T
--------
V
-----
D
AE
H
R
F
D
L
-------
P
EECGVSSV
N
-------
C
-----
L
D
L
A
R
E
-----------
L
E
F
--
L
R
A
H
I
------
S
L
S
---
K
S
P
V
-
T
---
F
C
H
N
D
L
Q
E
G
N
I
L
L
-----
P
-
K
--------
R
---
L
V
L
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
-
H
F
I
---
E
W
---------
T
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
-
N
D
Q
M
L
E
F
-
F
L
N
-
Y
L
R
E
Q
G
N
T
----
R
E
N
E
L
Y
K
K
S
-
E
D
L
-
V
Q
E
T
-
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
-
Q
V
E
L
---------------------------------------------------
25
Fugue
62.58
16%
-10
- C3 -
-
2QG7
-
?
A:
[50-458]
YPITESNLRILEGED
R
S
E
K
A
K
E
L
L
K
K
Y
V
S
N
V
F
E
N
E
K
T
L
-
Y
I
Y
C
K
Y
V
M
L
H
-
Y
GK
D
L
----
V
N
----
P
N
E
V
D
S
L
E
F
Q
I
I
N
G
T
--
N
I
L
I
K
-
V
K
DM
S
K
---------
Q
----------
A
K
Y
L
I
R
-
L
-
Y
-
G
P
T-------
D
--
E
-
I
--
I
-
N
R
E
R
E
K
K
I
S
C
I
L
Y
N
K
-
N
I
A
----------
K
K
I
-----
Y
V
---
F
F
----------
T
-
N
-
G
R
I
E
E
F
M
D
G
-----
Y
A
L
S
---
R
-
E
------
D
---
I
K
N
P
K
F
Q
-
K
L
I
A
-
K
N
L
K
L
-
L
H
---
D
----
I
-------------------------
K
L
N
E
-
N
-----------------
L
-----------
Y
---------------
K
----
E
L
Q
V
T
QKVPGTRPSF
L
W
N
T
I
W
K
Y
F
-----------------------
H
L
L
N
E
E
-
R
K
KICSFDAKA
N
I
L
--------
K
-----
L
--------------
I
--------
D
-------
F
-----
D
V
L
R
D
S
-----------
I
V
E
--
V
E
S
L
C
------
K
R
E
---
N
S
P
I
-
V
---
L
C
H
C
D
L
L
S
S
N
I
I
N
-----
T
-
V
-------
G
E
G
D
S
I
S
F
I
-
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
-
H
F
N
---
E
Y
AGFNCDWDL
T
P
------------------
S
-
K
E
E
E
Y
H
F
-
I
M
H
-
Y
L
-----------
G
T
D
D
E
E
L
I
-
N
Q
L
-
I
R
E
I
-
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
-
Q
G
M
H
S
-----
F
D
F
I
--
N
Y
G
M
T
R
L
T
A
S
C
L
P
I
F
R
S
K
V
--------------------
45
HHSearch
62.29
18%
-21
- C3 -
-
2QG7
-
?
D:
[112-433]
----------------------------------------------------------------------
E
F
Q
I
I
N
G
G
-
T
--
N
I
L
I
K
-
V
K
--
D
M
SK-------
Q
----------
A
K
Y
L
I
R
-
L
-
Y
-
G
P
--------
K
TD-------
N
R
E
R
E
K
K
I
S
C
I
L
Y
N
K
-
N
I
A
-
K
-------
K
--
I
-----
Y
V
---
F
F
----------
T
-
N
-
G
R
I
E
E
F
M
D
G
Y
----
A
L
S
R
EDI
K
-
N
------
P
---
K
F
----
Q
-
K
L
I
A
-
K
N
L
K
L
-
L
H
---
D
----
I
-------------------------
K
L
N
E
-
N
-----------------
L
-----------
Y
KELQVTQKVPGTRPS
F
----
L
W
-------------------
N
T
I
-----------------------
W
K
Y
F
H
L
-
L
----------
N
E
E
--------
R
-----
K
KICSFDAKANILKL
I
--------
D
-------
F
-----
D
V
L
R
D
S
-----------
I
V
E
--
V
E
S
L
C
------
K
R
E
---
N
S
P
I
-
V
---
L
C
H
C
D
L
L
S
S
N
I
I
N
-----
T
-
V
G------
D
S
---
I
S
F
I
-
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
-
H
F
N
---
E
Y
AGFNCDWDL
T
P
------------------
S
-
K
E
E
E
Y
H
F
-
I
M
H
-
Y
L
G
T
D
D
E
E
-----------
L
I
-
N
Q
L
-
I
R
E
I
-
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
-
Q
G
M
H
S
--------------------------------------------------
46
HHSearch
62.11
18%
-21
- C3 -
-
2QG7
-
?
E:
[112-433]
----------------------------------------------------------------------
E
F
Q
I
I
N
G
-
I
T
--
N
I
L
I
K
-
V
K
--
D
M
SK-------
Q
----------
A
K
Y
L
I
R
-
L
-
Y
-
G
P
--------
K
TD
E
-
I
--
I
-
N
R
E
R
E
K
K
I
S
C
I
L
Y
N
K
-
N
I
A
-
K
-------
K
--
I
-----
Y
V
---
F
F
----------
T
-
N
-
G
R
I
E
E
F
M
D
G
Y
----
A
L
S
R
EDI
K
-
N
------
P
---
K
F
----
Q
-
K
L
I
A
-
K
N
L
K
L
-
L
H
---
D
----
I
-------------------------
K
L
N
E
-
N
-----------------
L
-----------
Y
KELQVTQKVPGTRPS
F
----
L
W
-------------------
N
T
I
-----------------------
W
K
Y
F
H
L
-
L
----------
N
E
E
--------
R
-----
K
KICSFDAKANILKL
I
--------
D
-------
F
-----
D
V
L
R
D
S
-----------
I
V
E
--
V
E
S
L
C
------
K
R
E
---
N
S
P
I
-
V
---
L
C
H
C
D
L
L
S
S
N
I
I
N
-----
T
-
V
GG-----
D
S
---
I
S
F
I
-
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
-
H
F
N
---
E
Y
AGFNCDWDL
T
P
------------------
S
-
K
E
E
E
Y
H
F
-
I
M
H
-
Y
L
G
T
D
D
E
E
-----------
L
I
-
N
Q
L
-
I
R
E
I
-
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
-
Q
G
M
H
S
--------------------------------------------------
51
HHSearch
61.98
15%
-24
- C3 -
-
3C5I
3
?
D:
[11-332]
-----------------------------------
L
T
D
-
P
L
Y
I
K
K
I
C
L
E
K
V
--
P
E
----
W
N
HFTE
D
N
L
--
R
V
K
Q
I
L
--
L
T
--
N
Q
L
F
E
-
V
G
--
L
K
---------
E
E
T
A
N
N
Y
NSIR
T
R
V
L
F
R
-
I
-
Y
-
G
K
--------
H
VD
E
-
L
--
Y
-
N
T
I
S
E
F
E
V
Y
K
T
M
S
K
Y
-
K
I
A
-
P
-------
Q
--
L
-----
L
N
---
T
F
----------
N
-
G
-
G
R
I
E
E
W
L
Y
G
D
----
P
L
R
I
D
D
L
K
-
N
------
P
---
T
I
----
L
-
I
G
I
A
-
N
V
L
G
K
-
F
H
---
T
----
L
-------------------------
S
R
K
R
-
H
-----------------
L
PEH--------
W
DRTP-----------
C
----
I
F
-------------------
K
M
M
-----------------------
E
K
W
K
N
Q
-
L
----------
F
K
Y
--------
K
NIEKY
N
--------------
C
--------
D
-------
I
-----
H
K
Y
I
K
E
-----------
S
D
K
--
F
I
K
F
M
K
V
Y
S
KS
D
N
L
---
A
N
T
I
-
V
---
F
C
H
N
D
L
Q
E
N
N
I
I
N
-----
T
-
N
-------
K
C
---
L
R
L
I
-
D
F
E
Y
S
G
F
N
F
L
A
T
D
I
A
N
-
F
F
I
---
E
T
---------
S
I
DYSVSSYPF
F
E
I
D
KKKYI
S
-
Y
E
N
R
K
L
F
-
I
T
A
-
Y
L
S
N
Y
L
D
K
-----
V
V
P
T
P
K
L
I
-
D
E
I
-
L
E
A
V
-
E
V
Q
A
L
G
A
H
L
L
W
G
F
W
S
I
I
-
R
G
Y
Q
---------------------------------------------------
1
PsiBlast_PDB
60.90
21%
-14
- C3 -
-
4R78
2
?
A:
[35-252]
------------------------------------------------------------
Q
----
E
E
E
V
L
S
V
E
Q
L
G
-
G
M
T
--
N
Q
N
Y
L
-
A
K
--
T
T
---------
N
----------
K
Q
Y
I
V
K
-
F
-
F
-
G
K
--------
G
--
T
-
E
KL
I
-
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
L
-
G
L
D
-
V
-------
K
N
Y
L
-----
F
D
---
I
E
----------
A
-
G
-
I
K
V
N
E
Y
I
E
S
A
----
I
T
L
D
---
S
-
T
------
S
I
K
-
T
K
----
F
-
D
K
I
A
-
P
I
L
Q
T
-
I
H
---
T
SAKE
L
-------------------------
R
G
E
F
-
A
-----------------
P
-----------
F
---------------
E
----
E
I
-------------------
K
K
Y
-----------------------
E
S
L
I
E
E
-------------
Q
I
--------
P
-----
Y
--------------
A
--------
N
-------
Y
-----
E
S
V
R
N
A
-----------
V
F
S
--
L
E
K
R
L
------
A
D
L
---
G
V
D
R
-
K
---
S
C
H
I
D
L
V
P
E
N
F
I
E
-----
S
-
P
Q------
G
R
---
L
Y
L
I
-
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
-
L
F
L
---
E
S
---------
E
F
------------------
T
-
S
Q
E
E
E
T
F
-
L
S
H
-
Y
E
S
D
Q
---------------------------------------------------------------------------------------------------
31
Fugue
60.65
15%
-13
- C3 -
-
3HAM
3
?
A:
[1-299]
-------------------------------------
M
-
V
N
L
D
A
E
I
Y
E
H
-
L
--------
N
K
----
Q
I
K
I
N
E
L
R
Y
L
S
S
G
D
D
--
S
D
T
F
L
-
C
N
------------------------
E
Q
Y
V
V
K
-
V
P
K
-
R
D
--------
S
--
V
-
R
--
I
-
S
Q
K
R
E
F
E
L
Y
R
F
L
E
N
C
-
K
L
S
Y
Q
-------
I
P
A
V
-----
V
Y
---
Q
S
----------
D
-
R
-
F
N
I
M
K
Y
I
K
G
E
----
R
I
T
Y
---
E
-
Q
Y
H
K
LS
E
K
---
E
K
----
D
-
A
L
A
Y
-
D
E
A
T
F
-
L
K
---
E
----
L
-------------------------
H
S
I
E
-
I
DCSVSLFSDALVN
K
K
D
K
F
-----------
L
---------------
Q
----
D
K
-------------------
K
L
L
-----------------------
I
S
I
L
E
K
-
E
----------
Q
L
L
--------
T
-----
D
--------------
E
--------
M
-------
L
-----
E
H
I
E
T
I
-----------
Y
E
N
--
I
L
N
N
A
------
V
L
F
---
K
Y
T
P
-
C
---
L
V
H
N
D
F
S
A
N
N
M
I
F
-----
R
-
N
-------
N
R
---
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
-
L
L
D
---
C
S
---------
T
---------------------
D
D
F
G
K
E
F
-
G
R
K
-
V
L
K
Y
Y
Q
H
K
----
A
P
E
V
A
E
R
K
A
-
E
L
N
-
D
V
Y
---------
W
S
I
D
Q
I
I
Y
G
Y
-
E
R
K
D
R
-----
E
M
L
I
--
K
G
V
S
E
L
L
Q
T
Q
A
E
M
F
I
F
-----------------------
64
SP3
59.35
15%
-3
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-----------------G
M
K
E
L
L
S
T
M
D
L
D
T
D
A
N
T
I
P
E
L
-
K
E
R
A
H
M
L
C
A
R
-
F
--
L
G
GAWK
T
V
----
P
L
E
H
L
R
I
S
R
I
K
G
G
M
S
--
N
M
L
F
L
-
C
R
--
L
S
---------
E
VYPPIRNEP-
N
K
V
L
L
R
-
V
-
Y
-
F
N
--------
P
--
E
-
T
E
-
S
-
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
-
H
L
G
-
P
-------
K
--
L
-----
Y
G
---
I
F
----------
S
-
G
-
G
R
L
E
E
Y
I
P
S
R
----
P
L
S
C
---
H
-
E
------
I
S
L
A
H
M
----
S
-
T
K
I
A
-
K
R
V
A
K
-
V
H
---
Q
----
L
-------------------------
E
V
P
I
-
W
-----------------
K
-----------
E
---------------
P
D
Y
--
L
C
-------------------
E
A
L
-----------------------
Q
R
W
L
K
Q
-
L
----------
T
G
T
V
DAE
H
R
F
D
L
-----
P
--------------
E
--------
E
CGVSSVN
C
-----
L
D
L
A
R
E
-----------
L
E
F
--
L
R
A
H
I
------
S
L
S
---
K
S
P
V
-
T
---
F
C
H
N
D
L
Q
E
G
N
I
L
L
-----
P
---------
K
R
---
L
V
L
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
-
H
F
I
---
E
W
---------
T
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
-
N
D
Q
M
L
E
F
-
F
L
N
-
Y
L
R
E
Q
G
N
T
----
R
E
N
E
L
Y
K
K
S
-
E
D
L
-
V
Q
E
T
-
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
-
Q
V
E
L
S
-----
P
V
G
F
--
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA---------------
2
PsiBlast_PDB
58.95
21%
-11
- C3 -
-
4R7B
-
?
A:
[35-252]
------------------------------------------------------------
Q
----
E
E
E
V
L
S
V
E
Q
L
G
-
G
M
T
--
N
Q
N
Y
L
-
A
K
--
T
T
---------
N
----------
K
Q
Y
I
V
K
-
F
-
F
-
G
K
--------
G
--
T
-
E
KL
I
-
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
L
-
G
L
D
-
V
-------
K
N
Y
L
-----
F
D
---
I
E
----------
A
-
G
-
I
K
V
N
E
Y
I
E
S
A
----
I
T
L
D
---
S
-
T
------
S
I
K
-
T
K
----
F
-
D
K
I
A
-
P
I
L
Q
T
-
I
H
---
T
SAKE
L
-------------------------
R
G
E
F
-
A
-----------------
P
-----------
F
---------------
E
----
E
I
-------------------
K
K
Y
-----------------------
E
S
L
I
E
E
-------------
Q
I
--------
P
-----
Y
--------------
A
--------
N
-------
Y
-----
E
S
V
R
N
A
-----------
V
F
S
--
L
E
K
R
L
------
A
D
L
---
G
V
D
R
-
K
---
S
C
H
I
D
L
V
P
E
N
F
I
E
-----
S
-
P
Q------
G
R
---
L
Y
L
I
-
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
-
L
F
L
---
E
S
---------
E
F
------------------
T
-
S
Q
E
E
E
T
F
-
L
S
H
-
Y
E
S
D
Q
---------------------------------------------------------------------------------------------------
36
Fugue
58.29
13%
5
- C3 -
-
3JR1
3
?
A:
[14-309]
--------------------------------
N
L
Y
F
Q
G
M
W
K
S
I
S
Q
V
L
A
E
-
Q
--
F
------
G
----
A
Y
Y
F
I
K
H
K
E
K
L
Y
S
G
E
M-
N
E
I
W
L
-
I
N
--
D
E
---------
V
----------
Q
T
V
F
V
K
-
I
-
N
-
E
R
--------
S
--
Y
-
R
--
S
M
F
R
A
E
A
D
Q
L
A
L
L
A
K
T
N
-
S
I
N
-
V
-------
P
L
V
Y
-----
G
I
G
N
S
Q
G
----------
H
-
S
-
F
L
L
L
E
A
L
N
K
S
----
K
N
-------
K
------
Q
---
S
S
----
F
-
T
I
F
A
-
E
K
I
A
Q
-
L
H
---
Q
----
I
-------------------------
Q
G
P
D
-
K
-----------------
Y
GLD
F
D
T
W
L
GP
I
Y
---------------
Q
----
P
N
-------------------
D
W
Q
-----------------------
T
S
W
A
K
F
-
F
----------
S
E
N
--------
R
-----
I
--------------
G
--------
W
-------
Q
-----
L
Q
I
C
K
E
K
GLIFGN
I
D
L
I
V
Q
I
--
V
A
D
T
L
------
S
K
H
---
N
P
K
P
-
S
---
I
L
H
G
N
L
W
I
E
N
C
I
Q
-----
V
-
D
-------
D
K
---
I
F
V
C
-
N
P
-
A
C
Y
W
G
D
R
E
C
D
I
A
F
-
S
S
L
---
F
E
---------
P
F
------------------
P
-
T
N
F
Y
Q
R
Y
-
N
E
I
-
Y
P
L
E
E
G
Y
L
----
E
R
K
L
I
Y
Q
L
Y
-
Y
L
L
-
N
F
S
Y
-
R
Y
Y
N
-------------------------
K
K
Q
--
S
Y
V
S
L
T
Q
K
L
I
N
Q
I
L
H
K
-----------------------
37
Fugue
57.63
18%
3
- C3 -
-
3CSV
11
?
A:
[4-333]
------------------------------------
S
R
-
E
D
E
I
R
D
F
L
A
T
-----------------------
H
G
Y
A
D
W
N
R
--
T
P
R
Y
Q
R
L
R
--
S
P
---------
T
----------
G
A
K
A
V
L
M
D
-
W
-
S
P
--------
E
--
E
-
G
--
G
-
D
T
Q
P
F
V
D
L
A
Q
Y
L
R
N
L
-
D
I
S
-
A
-------
P
E
I
Y
-----
A
E
---
E
H
----------
A
-
R
G
L
L
L
I
E
D
L
G
D
A
L
F
T
-
E
V
I
N
---
N
-
D
------
P
---
A
Q
----
E
M
P
L
Y
R
-
A
A
V
D
L
-
L
I
---
H
----
L
-------------------------
H
-
D
A
-
Q
-----------------
T
-----------
P
---------------
E
----
L
A
-------------------
R
L
D
-----------------------
P
E
T
L
S
E
M
T
----------
R
L
A
--------
F
-----
S
EYRYAILGD-----
A
--------
A
-------
E
-----
D
N
R
K
R
F
-----------
E
H
R
--
F
A
Q
I
L
------
S
A
Q
---
L
E
G
D
M
V
---
F
V
H
R
D
F
H
A
Q
N
L
L
W
LPERE
G
-
L
-------
A
R
---
V
G
V
I
-
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
V
S
-
L
L
Q
---
D
A
---------
R
R
------------------
D
V
P
A
Q
V
E
A
Q
M
I
D
H
-
Y
I
Q
A
T
G
V
D
----
E
S
H
F
R
S
A
Y
A
-
V
I
A
-
V
Q
R
N
M
R
----
I
L
G
I
F
A
R
L
S
Q
R
F
G
K
R
H
Y
I
-----
E
F
V
P
--
R
V
W
A
H
F
E
R
G
L
A
H
P
A
L
A
S
A
A
E
E
I
L
N
A
L
PAPA
P
E
V
L
E
R
L
R
A
29
Fugue
56.07
15%
-16
- C3 -
-
3I1A
2
?
A:
[3-330]
------------------------------------
K
Q
-
P
I
Q
A
Q
Q
L
I
E
L
-
L
--
K
V
----
H
Y
----
G
I
D
I
H
T
A
Q
F
I
Q
G
G
A
D
TN
A
F
A
Y
Q
-
A
D
--
S
E
---------
S
----------
K
S
Y
F
I
K
-
L
-
K
-
Y
G
--------
Y
--
H
-
D
--
E
-
I
N
L
S
I
I
R
L
L
H
D
S
G
I
K
-
E
I
I
-
F
-------
P
I
H
T
LEAKL
F
Q
---
Q
L
----------
K
-
H
-
F
K
I
I
A
Y
P
F
I
H
A
P
N
G
F
T
Q
N
---
L
-
T
------
G
---
K
Q
----
W
-
K
Q
L
G
-
K
V
L
R
Q
-
I
H
---
E
----
T
-------------------------
S
V
P
I
-
S
-----------------
I
-----------
Q
---------------
Q
----
Q
L
-------------------
R
K
E
IYSP
K
W
R
E
I
V
R
S
F
Y
NQIEFDNSD
D
K
L
T
A
A
-
F
----------
K
S
F
--------
F
-----
N
--------------
Q
--------
N
-------
S
-----
A
A
I
H
R
L
-----------
V
D
T
--
S
E
K
L
S
------
K
K
I
QPD
L
D
K
Y
-
V
---
L
C
H
S
D
I
H
A
G
N
V
L
V
G----
N
-
E
-------
E
S
---
I
Y
I
I
-
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
-
I
G
G
GVG
N
V
---------
W
N
------------------
K
-
P
H
E
I
Q
Y
F
-
Y
E
G
-
Y
G
E
I
N
V
D
K
----
T
I
L
S
Y
Y
R
H
E
-
R
I
V
-
E
D
I
A
-
V
Y
G
Q
D
L
L
S
R
N
Q
N
N
Q
S
R
L
-
E
S
F
K
Y
-----
F
K
E
M
--
F
D
P
N
N
V
V
E
I
A
F
A
T
E
-------------------------
28
Fugue
55.41
14%
-22
- C3 -
-
2Q83
5
COTI_BACSU
A:
[11-346]
-----------------------------
L
S
A
E
D
A
K
K
L
-
T
E
L
A
E
N
V
L
Q
G
-
W
--
D
V
------------
Q
A
E
K
I
D
V
I
----
Q
--
A
L
V
W
K
-
V
H
--
T
D
---------
S
----------
G
A
V
C
L
K
-
R
-
I
-
H
R
--------
P
--
E
-
K
--
K
-
A
L
F
S
I
F
A
Q
D
Y
L
A
K
K
G
M
N
V
P
-
G
I
L
P
N
KKG
S
L
Y
S
-----
K
H
---
G
S
----------
F
-
L
-
F
V
V
Y
D
W
I
E
G
-----
R
P
F
E
---
L
-
T
------
V
---
K
Q
----
D
-
L
E
F
I
M
K
G
L
A
D
-
F
H
---
T
----
A
S
VG
Y
Q
P
P
NG
V
P
I
F
T
KLGR
W
P
N
H
Y
T
K
R
C
K
Q
M
E
-----------------
T
-----------
W
K
L
M
A
E
A
---------
E
----
K
E
-------------------
D
P
F
-----------------------
S
Q
L
Y
L
Q
-
E
----------
I
D
G
--------
F
-----
I
--------------
E
--------
D
-------
G
-----
L
R
I
K
D
R
-----------
L
L
Q
ST
Y
V
P
W
T
------
E
Q
L
---
K
K
S
P
-
N
---
L
C
H
Q
D
Y
G
T
G
N
T
L
L
-----
G
E
N
-------
E
Q
---
I
W
V
I
-
D
L
D
T
V
S
F
D
L
P
I
R
D
L
R
K
M
I
I
P
---
L
L
---------
D
T
------------------
T
-
G
V
W
D
D
E
T
-
F
N
V
M
L
N
A
Y
E
S
R
A
----
P
L
T
E
E
Q
K
Q
V
M
F
I
D
M
L
F
P
Y
-
E
L
Y
D
V
I
R
E
K
Y
V
R
K
S
A
L
P
-
K
E
E
L
E
-----
S
A
F
E
--
Y
E
R
I
K
A
N
A
L
R
Q
L
I
--------------------------