@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I1BMF0_RHIO9: (2019-01-29 )
MSATTDRTQRPLLSKSKKLNSLHSKSSPALNFDESHSLSIKRRKVNTRDPAVYFVTIGSKRMLLRIYGIGCEQILDRDKELDWLSRLSRLNIGPSLLGTFDNGRFEEYLESTTLTWHDLRDPFISAQIASRLNQLHSIVDTFPPAENEPLEVWQNIDKWYRSLESEVLSTLKKNPVWAKMIEQSLDLSQLHKDIETCKSILNTLSTPTVFAHNDTQYGNILKIENTDELVVIDFEYAGYNPRGYDIANHFCEWMYDYHSSEPAKMNHKSYPTHKEQVRFLTAYDKHHVTELLREVELWKMACHLFWGLWGLVQASQSEIDFDYFGYSLERLSVFKQELDAKATQIA
Atome Classification :
(20 SA)
---.........10........20....-.-...30--........40........50......----------.---------.----------60.......--.70..-......80........90........100.......110.......120.......130.......140--..------..-.---.----------..150.......160.......170-..----.....180.......190--------.....---..200--------------.------.......---.210.......220.---..-----..-----.-.230.......240.......250.....-.-.260-.-.--......270.......280.--------------...-----------..---------------.---------290---------.........300.......310.....--..320.......330.......340....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---MSATTDRTQR
P
L
L
S
K
S
K
K
L
N
S
L
HSK-S-SPALN--FDESHS
L
S
I
K
R
RKVNTRD
P
A
V
Y
F
V
T
I----------G---------S----------
K
R
M
L
L
R
I
YG--I
G
C
E
Q
-
I
L
D
RDK
E
L
D
W
L
S
R
L
S
RLNI
G
P
S
L
LGTFD
N
G
R
F
E
E
Y
L
E
STTL
T
W
H
DLRD
P
F
I
S
A
Q
I
A
S
R
L
N
Q
L
H
S
I
V
D
T---FP------PA-E---N----------
E
P
L
E
V
W
Q
N
I
D
K
W
Y
R
S
L
E
S
E
V
L
S
T
L
K-KN----
P
V
W
A
K
M
I
E
QSL
D
L
S
Q
L
H
K
--------
D
I
E
T
C
---
K
S
I
----------------
L
------
N
TLST
P
T
---
V
F
AHNDTQYG
N
I
L
K
I---EN-----TD-----
E
-
L
V
V
I
D
F
EYAGYNPRG
Y
D
I
A
N
H
F
C
E
W
M
Y
D
Y-H-SS-E-P-A--KMNHKSYP
T
H
K
E
Q
V
R
F
L
T
A
Y
--------------
D
K
H
-----------
H
V
---------------
T
---------
E
-----------
L
L
R
E
V
E
L
W
K
M
A
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L
F
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L
W
G
L
V
QASQS--EID
F
D
Y
FG
Y
S
L
E
R
L
S
V
F
K
Q
E
L
DAKATQIA
2
PsiBlast_PDB
85.49
32%
-50
- C8 -
-
3FEG
3
CHKB_HUMAN
A:
[83-368]
-----------------------------------------------------------------------------------------------
R
E
V
L
L
R
L
Y
G
-----
Q
G
-
V
D
S
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----
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--------
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---
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---
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L
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SEP--------
D
-----
S
-
L
M
L
V
D
F
E
Y
S
S
Y
N
Y
R
G
F
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I
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N
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F
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Y
D
Y
T
H
-
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-----------
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E
---------
D
-----------
L
L
V
E
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Y
A
L
A
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F
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W
G
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--
T
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E
F
G
Y
L
D
Y
A
Q
S
R
F
Q
F
Y
F
Q
Q
---------
48
HHSearch
84.83
30%
-14
* C8 *
-
5FTG
11
CHKA_HUMAN
A:
[8-377]
--------------
T
R
R
R
A
Y
L
W
C
K
E
F
L
P
-
G
A
W
R
G
L
-----
R
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D
E
F
H
I
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V
-
I
R
G
G
L
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N
M
L
F
Q
C
S
L
----------
P
---------
D
TTATLGDEP-
R
K
V
L
L
R
L
Y
G
---------
E
A
M
V
L
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V
M
F
A
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M
K
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P
---
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-
P
----------------
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---
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L
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L
------
E
S
T
P
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---
V
F
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D
C
Q
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N
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L
L
L
---
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RENSE
K
Q
-----
K
-
L
M
L
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F
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Y
S
S
Y
N
Y
R
G
F
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W
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Y
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Y
-
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Y
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K
Y
-
P
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--
R
A
N
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R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
--------------
L
P
A
-----------
F
Q
NDFENLS
T
E
E
K
S
I
I
K
E
---------
E
-----------
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
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S
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G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
F
H
Q
K
R
K
L
G
----
1
PsiBlast_PDB
83.58
32%
-50
- C8 -
-
3LQ3
2
CHKB_HUMAN
A:
[105-390]
-----------------------------------------------------------------------------------------------
R
E
V
L
L
R
L
Y
G
--
A
I
L
Q
G
-
V
D
S
L
V
L
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S
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M
F
A
I
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A
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A
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P
---
F
----------
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---
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----------
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Y
L
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P
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----
N
L
--------
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--------
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N
L
---
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K
L
----------------
L
------
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S
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P
S
P
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---
V
F
C
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N
D
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N
I
L
L
L
SEP--------
D
-----
S
-
L
M
L
V
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
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N
H
F
C
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W
V
Y
D
Y
T
H
-
E
E
-
W
-
P
F
Y
--
K
A
R
P
T
D
Y
P
T
Q
E
Q
Q
L
H
F
I
R
H
Y
L
A
E
A
K
KG
E
T
L
S
Q
E
E
Q
R
K
-----------
L
E
---------------
E
---------
D
-----------
L
L
V
E
V
S
R
Y
A
L
A
S
H
F
F
W
G
L
W
S
I
L
Q
A
S
M
S
--
T
I
E
F
G
Y
L
D
Y
A
Q
S
R
F
Q
F
Y
F
Q
Q
---------
3
PsiBlast_PDB
82.78
32%
-78
- C8 -
-
2IG7
-
CHKB_HUMAN
A:
[105-390]
-----------------------------------------------------------------------------------------------
R
E
V
L
L
R
L
Y
G
--
A
I
L
Q
G
-
V
D
S
L
V
L
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S
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M
F
A
I
L
A
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R
S
L
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I
P
S
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P
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L
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A
A
I
A
T
K
M
A
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H
G
M
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M
P
---
F
----------
T
---
K
----------
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P
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W
L
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G
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M
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Y
L
K
Q
I
Q
D
L
P
-------
M
----
N
L
--------
L
E
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Y
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L
K
D
--------
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M
G
N
L
---
R
K
L
----------------
L
------
E
S
T
P
S
P
V
---
V
F
C
H
N
D
I
Q
E
G
N
I
L
L
L
S------------------
L
M
L
V
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
W
V
Y
D
Y
T
H
-
E
E
-
W
-
P
F
Y
--
K
A
R
P
T
D
Y
P
T
Q
E
Q
Q
L
H
F
I
R
H
Y
L
A
E
A
K
KG
E
T
L
S
Q
E
E
Q
R
K
-----------
L
E
---------------
E
---------
D
-----------
L
L
V
E
V
S
R
Y
A
L
A
S
H
F
F
W
G
L
W
S
I
L
Q
A
S
M
S
--
T
I
E
F
G
Y
L
D
Y
A
Q
S
R
F
Q
F
Y
F
Q
Q
---------
49
HHSearch
82.75
30%
2
- C8 -
-
5FUT
10
CHKA_HUMAN
A:
[8-377]
--------------
T
R
R
R
A
Y
L
W
C
K
E
F
L
P
-
G
A
W
R
G
L
-----
R
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D
E
F
H
I
S
V
-
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
----------
P
---------
D
TTATLGDEP-
R
K
V
L
L
R
L
Y
G
-------G
A
E
A
M
V
L
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S
V
M
F
A
I
L
A
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R
S
L
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L
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D
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A
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F
H
G
M
K
M
P
---
F
N
------
K
E
-
P
----------------
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F
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Y
L
K
E
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L
R
I
K
F
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R
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K
L
H
K
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L
L
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Y
N
L
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S
L
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L
------
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S
T
P
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D
C
Q
E
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N
I
L
L
L
---
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RENSE
K
Q
-----
K
-
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
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N
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F
C
E
W
M
Y
D
Y
-
S
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Y
E
K
Y
-
P
F
F
--
R
A
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
--------------
L
P
A
-----------
F
Q
NDFENLS
T
E
E
K
S
I
I
K
E
---------
E
-----------
M
L
L
E
V
N
R
F
A
L
A
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H
F
L
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G
L
W
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Q
A
K
I
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F
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Y
M
D
Y
A
Q
A
R
F
D
A
Y
F
H
Q
K
R
K
L
G
----
52
HHSearch
80.24
26%
-23
- C8 -
-
3MES
3
?
A:
[51-411]
---------------
T
E
I
I
I
G
I
C
R
K
N
I
P
-
G
-
W
K
E
I
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N
E
S
Y
I
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K
Q
-
I
F
S
G
L
T
N
Q
L
F
V
V
S
I
----------
V
---------
N
ELKH------
P
R
I
L
F
R
I
Y
G
--
K
H
V
-
K
-
F
Y
D
S
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L
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I
N
I
A
P
N
I
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G
S
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N
S
K
---
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F
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D
----------
K
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I
L
F
K
R
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W
R
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A
K
I
Q
V
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N
N
---
I
----
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K
--------
E
L
Y
S
K
I
L
E
--------
E
I
D
Q
L
---
E
E
L
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GGEKFS
M
E
R
A
L
E
L
K
L
------
Y
S
P
A
F
S
L
---
V
F
A
H
N
D
L
Q
E
N
N
L
L
Q
T
---
Q
-------
N
-----
N
-
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
A
D
I
A
N
Y
F
C
E
Y
I
Y
D
Y
-
C
-
S
E
K
Q
-
P
Y
F
--
K
F
K
Y
E
D
Y
P
C
E
E
L
R
K
L
F
I
S
V
Y
--------------
L
S
Q
-----------
T
L
QEQVMPSQ
Q
I
V
----
H
---------
I
-----------
M
T
K
A
V
E
V
F
T
L
I
S
H
I
T
W
G
L
W
S
I
A
--------
V
E
F
D
F
T
E
Y
A
N
T
R
F
T
H
Y
L
Q
K
K
K
E
L
I
D
---
22
Blastp_CBE
80.12
34%
-7
- C8 -
-
2CKO
1
CHKA_HUMAN
B:
[85-381]
-------------------------------------------------------------
A
T
L
----------
G
DE-------
P
----------
R
K
V
L
L
R
L
Y
G
-----
E
A
-
M
V
---
L
E
S
V
M
F
A
I
L
A
E
R
S
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
M
------------
P
F
-
N
---
K
----------
E
P
K
W
L
F
G
T
M
E
K
Y
L
K
----
E
V
L
R
I
-------------
K
F
T
E
E
S
-
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
---
R
S
L
----------------
L
------
E
S
T
P
S
P
V
---
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
---
E
G
-----
R
E
NSEKQ
K
-
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
W
M
Y
D
Y
S
Y
-
E
K
-
Y
-
P
F
F
--
R
A
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
--------
D
F
E
-----------
N
L
---------------
S
T
E
E
K
S
I
I
K
E
E
-----------
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
--
S
I
E
F
G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
------------
53
HHSearch
79.63
26%
-19
- C8 -
-
3MES
2
?
B:
[51-411]
---------------
T
E
I
I
I
G
I
C
R
K
N
I
P
-
G
-
W
K
E
I
-----
N
E
S
Y
I
E
V
K
Q
-
I
F
S
G
L
T
N
Q
L
F
V
V
S
I
----------
V
---------
N
ELKH------
P
R
I
L
F
R
I
Y
G
--
K
H
V
---
F
Y
D
S
K
V
E
L
D
V
F
R
Y
L
S
N
I
N
I
A
P
N
I
I
A
D
F
P
E
G
R
I
E
E
F
I
D
G
E
P
L
T
T
K
Q
L
Q
L
T
H
I
C
V
E
V
A
K
N
M
G
S
L
H
I
I
N
S
K
---
R
A
------
D
F
-
P
SRF
D
----------
K
E
P
I
L
F
K
R
I
Y
L
W
R
E
E
A
K
I
Q
V
S
K
N
N
--
Q
I
----
D
K
--------
E
L
Y
S
K
I
L
E
--------
E
I
D
Q
L
---
E
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
L
------
Y
S
P
A
F
S
L
---
V
F
A
H
N
D
L
Q
E
N
N
L
L
Q
T
---
Q
-------
N
-----
N
-
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
A
D
I
A
N
Y
F
C
E
Y
I
Y
D
Y
-
C
-
S
E
K
Q
-
P
Y
F
--
K
F
K
Y
E
D
Y
P
C
E
E
L
R
K
L
F
I
S
V
Y
--------------
L
S
Q
-----------
T
L
QEQVMPSQ
Q
I
V
----
H
---------
I
-----------
M
T
K
A
V
E
V
F
T
L
I
S
H
I
T
W
G
L
W
S
I
A
-------
S
V
E
F
D
F
T
E
Y
A
N
T
R
F
T
H
Y
L
Q
K
K
K
E
L
I
D
---
66
Fugue
79.12
26%
13
- C8 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
M
D
L
D
T
D
A
N
T
I
P
E
L
K
E
R
A
H
M
L
-
C
-
A
R
F
L
G
GA
W
K
T
V
P
L
E
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
S
EVYPPIRN
E
---------
P
----------
N
K
V
L
L
R
V
Y
F
---
N
P
E
T
-
E
S
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
H
L
G
P
K
L
Y
G
I
F
S
G
G
R
L
E
E
Y
I
P
S
R
P
L
S
C
H
E
I
S
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
Q
---
L
---
E
V
------
P
I
-
W
---
K
----------
E
P
D
Y
L
C
E
A
L
Q
R
W
L
K
Q
L
T
G
T
-
V
D
A
E
H
-
R
F
----
D
L
P
E
E
C
G
V
S
S
V
N
C
L
D
L
A
R
--------
E
L
E
F
L
---
R
A
H
----------------
I
------
S
L
S
K
S
P
V
---
T
F
C
H
N
D
L
Q
E
G
N
---
I
---
L
L
-----
P
K
-----
R
-
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
I
D
Y
-
D
-
I
D
-
E
-
A
-
P
F
Y
K
I
Q
T
E
N
F
P
E
N
D
Q
M
L
E
F
F
L
N
Y
--------------
L
R
E
Q
GNTRENE
L
Y
K
K
S
---------------
E
---------
D
-----------
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
--
P
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
-
K
Q
L
L
K
N
L
A
44
HHSearch
78.53
27%
-5
- C8 -
-
1NW1
-
CKA2_CAEEL
A:
[50-422]
------------
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
G
A
-
W
K
T
V
-----
P
L
E
H
L
R
I
S
R
-
I
K
G
G
M
S
N
M
L
F
L
C
R
L
----------
S
EVYPPIRNE
P
----------
N
K
V
L
L
R
V
Y
F
--
N
P
E
T
--
E
S
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
H
L
G
P
K
L
Y
G
I
F
S
G
G
R
L
E
E
Y
I
P
S
R
P
L
S
C
H
E
I
S
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
Q
L
E
V
P
---
I
W
------
K
E
-
P
----------------
D
Y
L
C
E
A
L
Q
R
W
L
K
Q
L
T
G
T
V
D
A
E
H
R
F
D
L
----
P
E
E
C
-
G
V
S
-
S
V
N
C
L
D
L
A
R
--------
E
L
E
F
L
---
R
A
H
----------------
I
------
S
L
S
K
S
P
V
---
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
---
K
-------------
R
-
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
I
D
Y
-
D
-
I
D
E
A
-
P
F
Y
--
K
I
Q
T
E
N
F
P
E
N
D
Q
M
L
E
F
F
L
N
Y
--------------
L
R
E
-----------
Q
G
NTRENE
L
Y
K
K
S
----
E
---------
D
-----------
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
--
P
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
-----
50
HHSearch
78.40
28%
8
- C8 -
-
3C5I
3
?
D:
[14-357]
---------------
P
L
Y
I
K
K
I
C
L
E
K
V
P
-
E
-
W
N
H
F
-----
T
E
D
N
L
R
V
K
Q
-
I
L
--
L
T
N
Q
L
F
E
V
G
L
----------
K
---------
E
E
T
A
N
N
Y
NSIR
T
R
V
L
F
R
I
Y
G
--
K
H
V
D
E
-
L
Y
N
T
I
S
E
F
E
V
Y
K
T
M
S
K
Y
K
I
A
P
Q
L
L
N
T
F
N
G
G
R
I
E
E
W
L
Y
G
D
P
L
R
I
D
D
L
K
N
P
T
I
L
I
G
I
A
N
V
L
G
K
F
H
T
L
S
R
K
---
R
H
------
L
P
-
E
---
H
WD--------
R
T
P
C
I
F
K
M
M
E
K
W
K
N
Q
L
F
K
Y
K
N
I
----------
E
K
Y
N
------
C
D
I
H
K
Y
I
K
--------
E
S
D
K
F
---
I
K
F
----------------
M
K
V
Y
S
KS
D
N
L
A
N
T
I
---
V
F
C
H
N
D
L
Q
E
N
N
I
I
N
T
---
N
-------
K
-----
C
-
L
R
L
I
D
F
E
Y
S
G
F
N
F
L
A
T
D
I
A
N
F
F
I
E
T
S
I
D
Y
-
S
-
V
S
-
S
Y
P
F
F
--
E
I
D
K
K
K
Y
I
S
Y
E
N
R
K
L
F
I
T
A
Y
--------------
L
S
N
-----------
Y
L
DKVVPT
P
K
L
I
-----
D
---------
E
-----------
I
L
E
A
V
E
V
Q
A
L
G
A
H
L
L
W
G
F
W
S
I
I
R
G
Y
Q
T
KS
Y
N
E
F
D
F
F
L
Y
A
E
Q
R
L
K
M
Y
D
D
Q
K
E
-------
4
PsiBlast_PDB
78.11
34%
5
- C8 -
-
2CKO
1
CHKA_HUMAN
A:
[85-381]
-------------------------------------------------------------
A
T
L
----------
G
DE-------
P
----------
R
K
V
L
L
R
L
Y
G
AI------
M
V
---
L
E
S
V
M
F
A
I
L
A
E
R
S
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
M
------------
P
F
-
N
---
K
----------
E
P
K
W
L
F
G
T
M
E
K
Y
L
K
----
E
V
L
R
I
-------------
K
F
T
E
E
S
-
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
---
R
S
L
----------------
L
------
E
S
T
P
S
P
V
---
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
---
E
G
-----
R
E
NSEKQ
K
-
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
W
M
Y
D
Y
S
Y
-
E
K
-
Y
-
P
F
F
--
R
A
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
QN--------
D
F
E
-----------
N
L
---------------
S
T
E
E
K
S
I
I
K
E
E
-----------
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
--
S
I
E
F
G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
------------
43
HHSearch
78.08
27%
1
- C8 -
-
1NW1
-
CKA2_CAEEL
B:
[50-422]
------------
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
G
A
-
W
K
T
V
-----
P
L
E
H
L
R
I
S
R
-
I
K
G
G
M
S
N
M
L
F
L
C
R
L
----------
S
EVYPPIRNE
P
----------
N
K
V
L
L
R
V
Y
F
--
N
P
E
T
--
E
S
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
H
L
G
P
K
L
Y
G
I
F
S
G
G
R
L
E
E
Y
I
P
S
R
P
L
S
C
H
E
I
S
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
Q
L
E
V
P
---
I
W
------
K
E
-
P
----------------
D
Y
L
C
E
A
L
Q
R
W
L
K
Q
L
T
G
T
V
D
A
E
H
R
F
D
L
----
P
E
E
C
-
G
V
S
-
S
V
N
C
L
D
L
A
R
--------
E
L
E
F
L
---
R
A
H
----------------
I
------
S
L
S
K
S
P
V
---
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
---
K
-------------
R
-
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
I
D
Y
-
D
-
I
D
E
A
-
P
F
Y
--
K
I
Q
T
E
N
F
P
E
N
D
Q
M
L
E
F
F
L
N
Y
--------------
L
R
E
-----------
Q
G
NTRENE
L
Y
K
K
S
----
E
---------
D
-----------
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
--
P
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
-----
21
Blastp_CBE
77.47
34%
-8
- C8 -
-
2CKQ
1
CHKA_HUMAN
B:
[85-381]
-------------------------------------------------------------
A
T
L
----------
G
DE-------
P
----------
R
K
V
L
L
R
L
Y
G
AI---
E
A
-
M
V
---
L
E
S
V
M
F
A
I
L
A
E
R
S
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
M
------------
P
F
-
N
---
K
----------
E
P
K
W
L
F
G
T
M
E
K
Y
L
K
----
E
V
L
R
I
-------------
K
F
T
E
E
S
-
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
---
R
S
L
----------------
L
------
E
S
T
P
S
P
V
---
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
---
E
G
-----
R
-Q----
K
-
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
W
M
Y
D
Y
S
Y
-
E
K
-
Y
-
P
F
F
--
R
A
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N--------
D
F
E
-----------
N
L
---------------
S
T
E
E
K
S
I
I
K
E
E
-----------
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
--
S
I
E
F
G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
------------
5
PsiBlast_PDB
76.82
34%
11
- C8 -
-
2CKQ
1
CHKA_HUMAN
A:
[85-381]
-------------------------------------------------------------
A
T
L
----------
G
DE-------
P
----------
R
K
V
L
L
R
L
Y
G
------
A
-
M
V
---
L
E
S
V
M
F
A
I
L
A
E
R
S
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
M
------------
P
F
-
N
---
K
----------
E
P
K
W
L
F
G
T
M
E
K
Y
L
K
----
E
V
L
R
I
-------------
K
F
T
E
E
S
-
R
I
K
K
L
H
K
L
L
SYN
L
P
L
E
L
E
N
L
---
R
S
L
----------------
L
------
E
S
T
P
S
P
V
---
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
---
E
G
-----
R
E
NSKQ-
K
-
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
W
M
Y
D
Y
S
Y
-
E
K
-
Y
-
P
F
F
--
R
A
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N--------
D
F
E
-----------
N
L
---------------
S
T
E
E
K
S
I
I
K
E
E
-----------
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
--
S
I
E
F
G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
------------
45
HHSearch
76.41
28%
12
- C8 -
-
2QG7
-
?
E:
[108-452]
-----------------------------------------
V
D
S
L
E
F
Q
I
-
I
N
G
-
I
T
N
I
L
I
K
V
K
D
----------
M
SK-------
Q
----------
A
K
Y
L
I
R
L
Y
G
--
P
K
T
D
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-
I
I
N
R
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R
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K
K
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C
I
L
Y
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K
N
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A
K
K
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Y
V
F
F
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N
G
R
I
E
E
F
M
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Y
A
L
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R
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D
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K
N
P
K
F
Q
K
L
I
A
K
N
L
K
L
L
H
D
I
K
L
N
---
E
N
------
L
Y
-
K
---
E
LQVTQKVPGT
R
P
S
F
L
W
N
T
I
W
K
Y
F
H
L
L
N
E
E
R
K
K
I
C
S
-
F
-----
D
A
K
A
N
I
L
K
-
L
I
D
F
D
V
L
R
D
--------
S
I
V
E
V
---
E
S
L
----------------
C
------
K
R
E
N
S
P
I
---
V
L
C
H
C
D
L
L
S
S
N
I
I
N
T
---
V
G
G-----
D
-----
S
-
I
S
F
I
D
F
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Y
S
C
P
M
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R
A
Y
D
I
A
N
H
F
N
E
Y
A
G
F
N
-
C
-------------
D
W
D
L
T
P
S
K
E
E
E
Y
H
F
I
M
H
Y
--------------
L
G
T
-----------
D
D
EELI-----------
N
---------
Q
-----------
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
G
M
H
S
--
S
-
D
F
D
F
I
N
Y
G
M
T
R
L
T
A
S
C
L
P
---------
46
HHSearch
75.62
28%
10
- C8 -
-
2QG7
-
?
D:
[108-452]
-----------------------------------------
V
D
S
L
E
F
Q
I
-
I
N
G
G
-
T
N
I
L
I
K
V
K
D
----------
M
SK-------
Q
----------
A
K
Y
L
I
R
L
Y
G
--
P
K
T
D
----
N
R
E
R
E
K
K
I
S
C
I
L
Y
N
K
N
I
A
K
K
I
Y
V
F
F
T
N
G
R
I
E
E
F
M
D
G
Y
A
L
S
R
E
D
I
K
N
P
K
F
Q
K
L
I
A
K
N
L
K
L
L
H
D
I
K
L
N
---
E
N
------
L
Y
-
K
---
E
L
Q
V
T
Q
K
V
P
G
T
R
P
S
F
L
W
N
T
I
W
K
Y
F
H
L
L
N
E
E
R
K
K
I
C
S
-
F
-----
D
A
K
A
N
I
L
K
-
L
I
D
F
D
V
L
R
D
--------
S
I
V
E
V
---
E
S
L
----------------
C
------
K
R
E
N
S
P
I
---
V
L
C
H
C
D
L
L
S
S
N
I
I
N
T
---
V
G
------
D
-----
S
-
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
E
Y
A
G
F
N
-
C
-------------
D
W
D
L
T
P
S
K
E
E
E
Y
H
F
I
M
H
Y
--------------
L
G
T
-----------
D
D
EELI-----------
N
---------
Q
-----------
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
G
M
H
S
--
S
-
D
F
D
F
I
N
Y
G
M
T
R
L
T
A
S
C
L
P
---------
9
PsiBlast_PDB
73.62
28%
-15
- C8 -
-
3MES
3
?
A:
[104-405]
------------------------------------------------------------------------------------------------
R
I
L
F
R
I
Y
G
--
K
H
V
-
K
-
F
Y
D
S
K
V
E
L
D
V
F
R
Y
L
S
N
I
N
I
A
P
N
I
I
A
D
F
P
E
G
R
I
E
E
F
I
D
G
E
P
L
T
T
K
Q
L
Q
L
T
H
I
C
V
E
V
A
K
N
M
G
S
L
H
I
I
N
S
K
RAD
F
P
------
S
R
F
D
---
K
----------
E
P
I
-
L
F
K
R
I
Y
L
W
R
E
E
A
K
I
Q
V
----
S
-
K
N
NID
K
E
L
Y
S
K
I
L
E
E
I
D
Q
L
E
E
L
I
M
--------
G
G
E
K
F
S
M
E
R
A
L
----------------
E
------
L
K
L
Y
S
P
A
FSL
V
F
A
H
N
D
L
Q
E
N
N
L
L
Q
T
---
Q
N
-----
N
--------
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
A
D
I
A
N
Y
F
C
E
Y
I
Y
D
Y
-
C
-
S
E
-
K
-
Q
-
P
Y
F
K
F
K
Y
E
D
Y
P
C
E
E
L
R
K
L
F
I
S
V
Y
--------------
L
S
Q
-----------
T
L
---------------
Q
---------
E
QVMPSQ
Q
I
V
H
I
M
T
K
A
V
E
V
F
T
L
I
S
H
I
T
W
G
L
W
S
I
A
--------
V
E
F
D
F
T
E
Y
A
N
T
R
F
T
H
Y
L
Q
K
---------
25
Blastp_CBE
72.40
32%
-2
- C8 -
-
3C5I
3
?
B:
[68-352]
------------------------------------------------------------------------------------------------
R
V
L
F
R
I
Y
G
--
K
H
V
D
E
-
L
Y
N
T
I
S
E
F
E
V
Y
K
T
M
S
K
Y
K
I
A
P
Q
L
L
N
T
F
N
G
G
R
I
E
E
W
L
Y
G
D
P
L
R
I
D
D
L
K
N
P
T
I
L
I
G
I
A
N
V
L
G
K
F
H
T
L
S
R
K
RH-
L
P
EHWDRT
P
C
-
I
---
F
----------
K
M
M
E
K
W
K
N
Q
L
F
K
Y
K
N
I
E
-------
K
-
Y
N
----
C
D
I
H
K
Y
I
K
E
S
D
K
F
I
K
F
M
K
--------
V
Y
S
K
S
---
D
N
L
----------------
A
------
N
T
I
-------
V
F
C
H
N
D
L
Q
E
N
N
I
I
------
N
-----
T
------
K
C
L
R
L
I
D
F
E
Y
S
G
F
N
F
L
A
T
D
I
A
N
F
F
I
E
T
S
I
D
Y
-
S
V
S
S
-
Y
-
P
F
F
--
E
I
D
K
K
K
Y
I
S
Y
E
N
R
K
L
F
I
T
A
Y
L
S
N
Y
L
---------
D
-------------------------------PT
P
K
L
I
D
--
E
-----------
I
L
E
A
V
E
V
Q
A
L
G
A
H
L
L
W
G
F
W
S
I
I
R
G
Y
Q
T
--
K
--
F
D
F
F
L
Y
A
E
Q
R
L
K
M
Y
------------
6
PsiBlast_PDB
72.05
32%
-12
- C8 -
-
3C5I
2
?
A:
[68-352]
------------------------------------------------------------------------------------------------
R
V
L
F
R
I
Y
G
--
K
H
V
D
E
-
L
Y
N
T
I
S
E
F
E
V
Y
K
T
M
S
K
Y
K
I
A
P
Q
L
L
N
T
F
N
G
G
R
I
E
E
W
L
Y
G
D
P
L
R
I
D
D
L
K
N
P
T
I
L
I
G
I
A
N
V
L
G
K
F
H
T
L
S
R
K
RH-
L
P
EHWDRT
P
C
-
I
---
F
----------
K
M
M
E
K
W
K
N
Q
L
F
K
Y
K
N
I
E
-------
K
-
Y
-----
C
D
I
H
K
Y
I
K
E
S
D
K
F
I
K
F
M
K
--------
V
Y
S
K
S
---
D
N
L
----------------
A
------
N
T
I
-------
V
F
C
H
N
D
L
Q
E
N
N
I
I
------
N
-----
T
N
------C
L
R
L
I
D
F
E
Y
S
G
F
N
F
L
A
T
D
I
A
N
F
F
I
E
T
S
I
D
Y
-
S
V
S
S
-
Y
-
P
F
F
--
E
I
D
K
K
K
Y
I
S
Y
E
N
R
K
L
F
I
T
A
Y
L
S
N
Y
L-----------------------------------------PT
P
K
L
I
D
--
E
-----------
I
L
E
A
V
E
V
Q
A
L
G
A
H
L
L
W
G
F
W
S
I
I
R
G
Y
Q
T
--
K
--
F
D
F
F
L
Y
A
E
Q
R
L
K
M
Y
------------