@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : K2DGB0_9BACT: (2019-01-30 )
MNRNKQKSKDYQSFLKNRHDKLNTSDDVLEKIVKNAVGYGIKDKQKIVEGEINEVYDITPTKGDNLIVRVSREEHNRFEAEKWALDNCRNAGVSVPQIILLDEVETDKEKLHICVENKIEGVSLQELIKQKVLSQSEIKDLTISAGEILSKIHSIKAKNFGEINSLGVGKFETWPEYMLEQNKNSDIVLEKAKNISIDPKLIQQAIEILEKTQDMYMNVDSRLAHSDYGIKHMLIHEGKINGIIDFENCKSSDIAYDFSYWNYFGKNRPSVEWLMEGYKSNGNFGENFEARMHLVKIKIALSLLIYYSDAGHGFAKEITTNNLIEDITFFNYVK
Atome Classification :
(20 SA)
.........10........20...-.....30........--40.........50.-.......60........70..----..----..-..80........90.---.--.......100...-.----.---..------110.......120.....-.-.130-----........140.......150...---..-.-.160.---..-------.-------...170-------.......180-.....-...190...---.--.---..200..-.....210-........220.-......230.....----.---.240.......250.......---260-.-.-.--.--------.----...270.......280-----------.....-....290.......300.......310.......320.......330..--------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNR
N
K
Q
K
S
K
D
Y
Q
S
F
L
K
N
RHDKLNT-
S
D
D
V
L
E
K
I
V
K
N
AVGY--G-IK
D
K
Q
K
I
VEGEI-N
E
V
Y
D
ITPTKGD
N
L
I
V
R
V
SRE----EH----NR-
F
E
A
E
K
W
A
LDNCRN-A---G--VSV
P
Q
I
I
L
L
DEVE-T----
D
---
K
E
------
K
L
H
I
C
VENKIEGV
S
L
Q
E
L
-
I
-
K
Q
K------VL
S
Q
SEI
K
D
L
T
I
S
A
G
E
I
L
S
K
I
H
S
I
---
K
A-K-NFGEI---NS-------L-------GVGKF
E
-------
T
W
P
E
Y
M
L
E-Q-NKNS
D
-
I
V
L
E
KAKNI---S--I---
D
P
K
L
I
Q
Q
-
A
I
E
I
L
E
K
--
T
Q
D
M
Y
M
N
V
D
S
R
L-AHSDYG
I
K
H
M
L
I
HE----G---KI
N
G
I
I
D
FENCKSSD
I
A
Y
D
F
S
---
Y
W
--
N
-
Y
-F--G--------K----NRP
S
V
E
W
L
M
E
G
Y
KS-------------NGNFG-E
N
F
E
A
R
M
H
L
V
K
I
K
I
A
L
S
L
L
I
Y
YSDAGHG
F
A
K
EITTN
N
L
I
E
D
I
T
F
FNYVK--------------------
41
HHSearch
79.99
19%
-9
- C1 -
-
3F7W
7
?
A:
[2-271]
--------------------------
V
N
S
V
A
A
R
V
T
E
L
T
G
R
--
E
-
V
A
A
V
A
E
R
G
H
S
H
R
-
W
H
L
Y
R
V
E
L
A
D
G
T
P
L
F
V
K
A
L
P
D
----
D
A
PALD
G
L
-
F
R
A
E
A
L
G
L
D
W
L
G
R
S
F
---
G
--
S
P
V
P
Q
V
A
G
W
D
----------------------
D
R
T
L
A
M
E
W
V
D
E
R
P
P
T
P
---------------------
E
A
A
E
R
F
G
H
Q
L
A
A
M
H
L
A
---
G
A
-
E
-
S
F
G
A
T
---
W
D
G
Y
IGP
L
P
M
-------
D
N
T
P
R
S
-------
T
W
P
E
F
Y
A
E
-
Q
R
I
L
P
Y
---
L
R
R
A
A
D
R
G
---
A
--
L
T
P
G
D
V
R
L
V
E
K
-
V
L
D
A
L
----
D
H
L
A
G
D
P
E
P
P
A
R
-
I
H
G
D
L
W
N
G
N
V
L
W
Q
D
----
D
---
G
-
A
V
V
I
D
P
A
-
A
H
G
G
H
R
E
A
D
L
A
---
M
L
--
A
-
L
-
F
--
G
--------------
L
P
Y
L
D
R
V
R
D
A
Y
N
E
-------------
V
A
P
L
A
-
E
G
W
R
A
R
I
P
L
H
Q
L
H
P
L
L
V
H
V
C
L
F
G
----------------------------------------------
56
Fugue
77.49
17%
7
- C1 -
-
4OCV
2
?
A:
[24-378]
---
T
N
E
A
L
F
D
V
A
S
-----
H
F
A
L
E
G
-
T
V
D
S
I
E
P
-------
Y
--
G
---------
D
G
H
I
-
N
T
T
Y
L
V
T
T
D
G
P
R
Y
I
L
Q
R
M
N
T
G
IFPD
T
V
----
N
L
-
M
R
N
V
E
L
V
T
S
T
L
K
A
-
Q
---
G
--
K
E
T
L
D
I
V
R
T
T
S
G
D
-
T
----
W
---
A
E
IDG
G
A
W
R
V
Y
K
F
I
E
H
T
M
S
----------
Y
N
L
------
V
P
N
P
D
V
F
R
E
A
G
R
A
F
G
D
F
Q
N
F
L
S
G
F
---
D
A
-
N
-
Q
L
T
E
T
---
I
A
-------
H
FHD----
T
P
H
R
F
E
-------
D
F
K
K
A
L
A
A
-
D
-
E
L
G
R
A
-
A
G
C
G
P
E
I
E
F
---
Y
--
L
---
S
--
H
A
D
Q
-
Y
A
V
V
M
D
G
--
L
R
D
G
--
S
I
P
L
R
V
-
T
H
N
D
T
K
L
N
N
I
L
M
D
A
TT--
G
---
K
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
---
D
S
--
I
-
R
-
F
--
G
ASTALEDE
R
----
D
L
D
K
V
H
F
S
T
E
L
F
R
A
Y
T
E
G
F
V
G
E
L
R
DSI
T
A
R
E
A
-
E
L
L
P
F
S
G
N
L
L
T
M
E
C
G
M
R
F
L
A
D
Y
L
E
G
D
V
Y
F
A
T
K
Y
P
E
H
N
L
V
R
S
R
T
Q
I
K
L
V
R
E
M
E
Q
R
A
D
E
T
R
A
I
V
A
D
V
M
E
T
T
32
HHSearch
76.41
17%
-49
- C1 -
-
3W0S
2
KHYB_ECOLX
A:
[6-282]
-----------------------
L
-
T
A
T
S
V
E
K
F
L
I
E
K
F
D
---
S
-
V
S
D
L
M
Q
L
S
E
G
E
E
-
S
R
A
F
S
F
D
V
G
G
-
R
G
Y
V
L
R
V
N
S
C
----
A
-----
D
G
-
F
Y
K
D
R
Y
V
Y
R
H
F
A
S
-
A
---
A
--
L
P
I
P
E
V
L
D
I
G
E
F
-----------
S
E
------
S
L
T
Y
C
I
S
R
R
A
Q
G
V
T
L
Q
D
L
--------------
P
E
T
E
L
P
A
V
L
Q
P
V
A
E
A
M
D
A
I
A
A
A
---
D
L
-
S
-
Q
T
S
G
F
G
PF
G
P
-------
Q
-------
G
I
G
Q
Y
T
-------
T
W
R
D
F
I
C
A
-
I
-
A
D
P
H
V
Y
H
W
Q
T
V
M
D
D
-------
T
---
V
S
A
S
V
A
Q
A
L
D
E
L
M
----
L
W
A
E
D
C
P
E
V
R
H
L
-
V
H
A
D
F
G
S
N
N
V
L
T
D
N
----
G
---
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
S
Q
Y
E
V
A
---
N
I
--
F
-
F
-
W
--
R
--------
P
WL
A
C
M
E
Q
Q
T
R
Y
F
E
R
R
H
P
E
-------------
L
------
A
G
S
P
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
Y
Q
S
L
V
D
G
N
------------------------------------------
37
HHSearch
75.55
19%
6
- C1 -
-
5IWU
2
?
A:
[4-298]
-------------------------
D
I
K
Q
V
I
E
I
A
K
K
-
H
N
L
FL
K
-
E
E
T
I
Q
F
N
E
S
G
L
D
-
F
Q
A
V
F
A
Q
D
N
N
G
I
D
W
V
L
R
L
P
R
R
----
E
D
V
M
--
P
R
-
T
K
V
E
K
Q
A
L
D
L
V
N
K
-
Y
---
A
IS
F
Q
A
P
N
W
I
I
Y
----------------------
T
E
E
L
I
A
Y
K
K
L
D
G
V
P
A
G
T
I
-
D
-
H
N
I
GNYIWE
I
D
I
N
N
V
P
E
L
F
H
K
S
L
G
R
V
L
A
E
L
H
S
I
---
P
S
-
N
-
K
A
A
A
L
---
D
L
-------
V
--------
V
H
T
P
E
-------
E
A
R
M
S
M
K
Q
-
R
-
M
D
A
----
V
R
A
K
F
G
--------
V
---
G
E
N
L
W
N
R
-
W
Q
A
W
L
----
N
D
D
D
M
W
P
K
K
T
G
L
-
I
H
G
D
V
H
A
G
H
T
M
I
D
K
D---
A
---
N
V
T
G
L
I
D
W
T
E
A
K
V
T
D
V
S
H
D
F
I
---
F
N
--
Y
-
R
-
A
--
F
-------------
G
E
E
G
L
E
A
L
I
L
A
Y
K
E
-------------
I
G
G
Y
Y
W
P
K
M
K
E
H
I
I
E
L
N
A
A
Y
P
V
S
I
A
E
F
A
L
V
S
G
I
E
E
Y
E
Q
M
A
K
E
A
L
E
------------------------------
38
HHSearch
73.32
19%
9
- C1 -
-
5UXA
-
?
A:
[4-298]
-------------------------
D
I
K
Q
V
I
E
I
A
K
K
-
H
N
L
FL
K
-
E
E
T
I
Q
F
N
E
S
G
L
D
-
F
Q
A
V
F
A
Q
D
N
N
G
I
D
W
V
L
R
L
P
R
R
----
E
D
V
M
--
P
R
-
T
K
V
E
K
Q
A
L
D
L
V
N
K
-
Y
---
A
IS
F
Q
A
P
N
W
I
I
Y
----------------------
T
E
E
L
I
A
Y
K
K
L
D
G
V
P
A
G
T
I
-
D
-
H
N
I
GNYIWE
I
D
I
N
N
V
P
E
L
F
H
K
S
L
G
R
V
L
A
E
L
H
S
I
---
P
S
-
N
-
K
A
A
A
L
---
D
L
-------
V
--------
V
H
T
P
E
-------
E
A
R
M
S
M
K
Q
-
R
-
M
D
A
----
V
R
A
K
F
G
--------
V
---
G
E
N
L
W
N
R
-
W
Q
A
W
L
----
N
D
D
D
M
W
P
K
K
T
G
L
-
I
H
G
D
V
H
A
G
H
T
M
I
D
K
D---
A
---
N
V
T
G
L
I
D
W
T
E
A
K
V
T
D
V
S
H
D
F
I
---
F
N
--
Y
-
R
-
A
--
F
-------------
G
E
E
G
L
E
A
L
I
L
A
Y
K
E
-------------
I
G
G
Y
Y
W
P
K
M
K
E
H
I
I
E
L
N
A
A
Y
P
V
S
I
A
E
F
A
L
V
S
G
I
E
E
Y
E
Q
M
A
K
E
A
L
E
------------------------------
25
HHSearch
68.92
15%
25
- C1 -
-
3JR1
3
?
A:
[15-309]
-------------------
L
Y
F
Q
G
-
M
W
K
S
I
S
Q
V
L
A
E
Q
F
G
A
Y
Y
F
-
I
K
H
K
E
K
L
Y
S
G
E
M
-
N
E
I
W
L
I
N
D
E
V
-
Q
T
V
F
V
K
I
N
E
R
----
S
Y
R
---
S
M
-
F
R
A
E
A
D
Q
L
A
L
L
A
K
T
N
---
S
--
I
N
V
P
L
V
Y
G
I
G
N
------------
S
Q
------
G
H
S
F
L
L
L
E
A
L
N
K
S
K
N
K
---------------------
Q
S
S
F
T
I
F
A
E
K
I
A
Q
L
H
Q
I
---
Q
G
-
P
D
K
Y
G
L
D
---
F
D
-------
T
W
L
GP
I
Y
Q
P
N
D
W
Q
T
-------
S
W
A
K
F
F
S
E
N
R
-
I
G
W
----
Q
L
Q
I
C
K
E
K
---
G
--
L
---
I
F
G
N
I
D
L
-
I
V
Q
I
V
A
---
D
T
L
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K
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N
P
K
P
S
I
-
L
H
G
N
L
W
I
E
N
C
I
Q
V
D
----
D
---
K
I
F
-
V
C
N
P
-
A
C
Y
W
G
D
R
E
C
D
I
A
---
F
S
--
S
-
L
-
F
--
E
---------------
P
F
P
T
N
F
Y
Q
R
Y
N
E
-------------
I
Y
P
L
E
-
E
G
Y
L
E
R
K
L
I
Y
Q
L
Y
Y
L
L
N
F
S
Y
R
Y
Y
N
K
-
K
Q
S
Y
V
S
L
T
Q
K
L
I
N
Q
I
L
H
K
-------------------------
28
HHSearch
68.07
16%
29
- C1 -
-
3TDW
1
?
A:
[4-301]
-------------------------
N
K
L
H
Y
T
T
M
I
M
T
Q
F
P
D
I-
S
-
I
Q
S
V
E
S
L
G
E
G
F
R
-
N
Y
A
I
L
V
---
N
-
G
D
W
V
F
R
F
P
K
S
----
Q
Q
G
A
--
D
E
-
L
N
K
E
I
Q
L
L
P
L
L
V
G
C
V
---
K
--
V
N
I
P
Q
Y
V
Y
I
G
K
R
-----------
S
D
------
G
N
P
F
V
G
Y
R
K
V
Q
G
Q
I
L
G
E
D
-
G
M
A
V
--------
L
P
D
D
A
K
D
R
L
A
L
Q
L
A
E
F
M
N
E
L
S
A
F
---
P
V
-
E
-
T
A
I
S
A
---
G
------------------
V
P
V
T
-------
N
L
K
N
K
I
L
L
-
L
-
S
E
A
V
E
D
Q
V
F
P
L
L
D
E
-------
S
---
L
R
D
Y
L
T
L
R
F
Q
S
Y
M
----
T
H
P
V
Y
T
R
Y
T
P
R
L
-
I
H
G
D
L
S
P
D
H
F
L
T
N
L
NSRQ
T
---
P
L
T
G
I
I
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
V
---
Y
L
--
L
-
E
-
D
--
C
--------
G
----
E
--
L
F
T
R
Q
V
M
A
Y
R
G
-------------
E
V
D
L
D
--
T
H
I
R
K
V
S
L
F
V
T
F
D
Q
V
S
Y
L
L
E
G
L
R
A
R
D
Q
D
W
I
S
E
G
L
E
L
L
E
E
D
K
A
N
N
F
-----------------------
4
PsiBlast_PDB
67.48
18%
-49
- C1 -
-
3W0O
2
KHYB_ECOLX
A:
[22-236]
--------------------------------------------
V
S
D
L
M
Q
L
S
E
G
E
E
-
S
R
A
F
S
F
D
-
V
G
G
R
G
Y
V
L
R
V
N
-
S
----
C
A
----
D
G
-
F
Y
K
D
R
Y
V
Y
R
H
F
A
S
-
A
---
A
--
L
P
I
P
E
V
L
D
I
G
E
F
-----------
S
E
------
S
L
T
Y
C
I
S
R
R
A
Q
G
V
T
L
Q
D
L
--------------
P
E
T
E
L
P
A
V
L
Q
P
V
A
E
V
M
D
A
I
A
A
A
DLS
Q
T
-
S
-
G
F
G
P
F
---
G
P
-------
Q
-------
G
I
G
Q
Y
T
-------
T
W
R
D
F
I
C
A
-
I
-
A
D
P
H
V
-
Y
H
W
Q
T
V
M
D
D
---
T
--
V
---
S
A
S
V
A
Q
A
-
L
D
E
L
M
L
W
--
A
E
D
C
--
P
E
V
R
H
L
-
V
H
A
D
F
G
S
N
N
V
L
T
D
N
----
G
---
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
F
F
W
--
R
--------------------------------------------------------------------------------------------------------------------------
57
Fugue
67.41
11%
-6
- C1 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
----------------
S
A
F
T
F
Q
T
L
-
H
P
D
T
I
M
D
A
L
F
E
-
H
G
I
--
R
-
V
D
S
G
L
T
P
L
N
S
Y
E
-
N
R
V
Y
Q
F
Q
D
E
D
R
R
R
F
V
V
K
F
Y
R
P
----
E
R
WT
A
-
D
Q
-
I
L
E
E
H
Q
F
A
L
Q
L
V
N
-
D
---
E
--
V
P
V
A
A
P
V
A
F
N
G
Q
T
L
L
----
N
---
H
Q
------
G
F
Y
F
A
V
F
P
S
V
G
G
R
Q
F
E
A
------------------
D
N
I
D
Q
M
E
A
V
G
R
Y
L
G
R
M
H
Q
T
---
G
R
-
K
-
Q
--
L
F
---
I
H
-------
R
-------
P
T
I
G
L
N
-------
E
Y
L
I
E
P
R
K
-
L
-
F
E
D
A
T
-
L
I
P
S
G
----------
L
---
K
A
A
F
L
K
A
-
T
D
E
L
I
A
A
--
V
T
A
H
W
R
E
D
F
T
V
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
----
G
-----
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
---
M
L
LN
G
-
D
-
K
--
A
--------
E
----
Q
R
M
Q
L
E
T
I
I
E
A
Y
E
E
-------------
F
S
E
F
D
-
T
A
E
I
G
L
I
E
P
L
R
A
M
R
L
V
Y
Y
L
A
W
L
M
R
R
W
A
D
P
A
F
P
K
N
F
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
EPPLQLTPMY
2
PsiBlast_PDB
67.31
18%
-48
- C1 -
-
3W0M
1
KHYB_ECOLX
A:
[22-236]
--------------------------------------------
V
S
D
L
M
Q
L
S
E
G
E
E
-
S
R
A
F
S
F
D
-
V
G
G
R
G
Y
V
L
R
V
N
-
S
----
C
A
----
D
G
-
F
Y
K
D
R
Y
V
Y
R
H
F
A
S
-
A
---
A
--
L
P
I
P
E
V
L
D
I
G
E
F
-----------
S
E
------
S
L
T
Y
C
I
S
R
R
A
Q
G
V
T
L
Q
D
L
--------------
P
E
T
E
L
P
A
V
L
Q
P
V
A
E
V
M
D
A
I
A
A
A
DLS
Q
T
-
S
-
G
F
G
P
F
---
G
P
-------
Q
-------
G
I
G
Q
Y
T
-------
T
W
R
D
F
I
C
A
-
I
-
A
D
P
H
V
-
Y
H
W
Q
T
V
M
D
D
---
T
--
V
---
S
A
S
V
A
Q
A
-
L
D
E
L
M
L
W
--
A
E
D
C
--
P
E
V
R
H
L
-
V
H
A
D
F
G
S
N
N
V
L
T
D
N
----
G
---
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
F
F
W
--
R
--------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
66.95
18%
-56
- C1 -
-
3W0P
2
KHYB_ECOLX
A:
[22-236]
--------------------------------------------
V
S
D
L
M
Q
L
S
E
G
E
E
-
S
R
A
F
S
F
D
-
V
G
G
R
G
Y
V
L
R
V
N
-
S
----
C
A
----
D
G
-
F
Y
K
D
R
Y
V
Y
R
H
F
A
S
-
A
---
A
--
L
P
I
P
E
V
L
D
I
G
E
F
-----------
S
E
------
S
L
T
Y
C
I
S
R
R
A
Q
G
V
T
L
Q
D
L
--------------
P
E
T
E
L
P
A
V
L
Q
P
V
A
E
V
M
D
A
I
A
A
A
DLS
Q
T
-
S
-
G
F
G
P
F
---
G
P
-------
Q
-------
G
I
G
Q
Y
T
-------
T
W
R
D
F
I
C
A
-
I
-
A
D
P
H
V
-
Y
H
W
Q
T
V
M
D
D
---
T
--
V
---
S
A
S
V
A
Q
A
-
L
D
E
L
M
L
W
--
A
E
D
C
--
P
E
V
R
H
L
-
V
H
A
A
F
G
S
N
N
V
L
T
D
N
----
G
---
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
F
F
W
--
R
--------------------------------------------------------------------------------------------------------------------------
24
HHSearch
66.92
20%
37
- C- -
-
3N4U
-
?
A:
[3-295]
----------------------
T
Y
-
T
F
D
Q
V
E
K
A
I
E
Q
L
Y
P
D
F-
T
-
I
N
T
I
E
I
S
G
E
G
N
D
-
C
I
A
Y
E
I
---
N
-
R
D
F
I
F
K
F
P
K
H
----
S
R
G
S
--
T
N
-
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
---
P
--
L
P
I
P
E
V
V
F
T
G
M
P
--
S
----
E
---
T
Y
------
Q
M
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
-
L
L
N
N
--------
L
P
K
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
---
N
I
-
S
-
G
F
K
S
N
---
L
--------------------
V
L
-------
D
F
R
E
K
I
N
E
-
D
-
N
K
K
----
I
K
K
L
L
S
R
E
---
L
K
G
P
---
Q
M
K
K
V
D
D
F
Y
R
D
I
L
----
E
N
E
I
Y
F
K
Y
Y
P
C
L
-
I
H
N
D
F
S
S
D
H
I
L
F
D
T
EK--
N
---
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
---
S
L
--
M
-
E
-
D
DE
E
--------
Y
----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
-------------
K
D
I
P
---
T
V
L
E
K
Y
R
M
K
E
K
Y
W
S
F
E
K
I
I
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
I
-------------------------------
3
PsiBlast_PDB
66.69
18%
-47
- C1 -
-
3W0N
2
KHYB_ECOLX
A:
[22-236]
--------------------------------------------
V
S
D
L
M
Q
L
S
E
G
E
E
-
S
R
A
F
S
F
D
-
V
G
G
R
G
Y
V
L
R
V
N
-
S
----
C
A
----
D
G
-
F
Y
K
D
R
Y
V
Y
R
H
F
A
S
-
A
---
A
--
L
P
I
P
E
V
L
D
I
G
E
F
-----------
S
E
------
S
L
T
Y
C
I
S
R
R
A
Q
G
V
T
L
Q
D
L
--------------
P
E
T
E
L
P
A
V
L
Q
P
V
A
E
V
M
D
A
I
A
A
A
DLS
Q
T
-
S
-
G
F
G
P
F
---
G
P
-------
Q
-------
G
I
G
Q
Y
T
-------
T
W
R
D
F
I
C
A
-
I
-
A
D
P
H
V
-
Y
H
W
Q
T
V
M
D
D
---
T
--
V
---
S
A
S
V
A
Q
A
-
L
D
E
L
M
L
W
--
A
E
D
C
--
P
E
V
R
H
L
-
V
H
A
D
F
G
S
N
N
V
L
T
D
N
----
G
---
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
F
F
W
--
R
--------------------------------------------------------------------------------------------------------------------------
26
HHSearch
66.45
15%
6
- C1 -
-
5IGH
-
?
A:
[5-297]
---------------------
T
T
A
-
D
T
S
Q
L
Y
A
L
A
A
R
-
H
G
L
--
K
L
H
G
P
L
T
V
N
E
L
G
L
D
-
Y
R
I
V
I
A
T
V
D
D
G
R
R
W
V
L
R
I
P
R
R
----
A
E
V
S
--
A
K
-
V
E
P
E
A
R
V
L
A
M
L
K
N
R
L
---
P
--
F
A
V
P
D
W
R
V
A
N
A
E
L
-
V
A
---
Y
---
P
M
------
L
E
D
S
T
A
M
V
I
Q
P
G
S
S
T
P
D
W
-
V
------------
V
P
Q
D
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
H
A
V
---
P
I
-
S
-
A
A
V
D
A
---
G
M
-------
L
--------
I
R
T
P
T
-------
Q
A
R
Q
K
V
A
D
-
D
-
V
D
R
----
V
R
R
E
F
V
--------
V
---
N
D
K
R
L
H
R
-
W
Q
R
W
L
----
D
D
D
S
S
W
P
D
F
S
V
V
-
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T---
E
---
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
---
A
H
--
L
-
M
-
V
--
F
--------
G
-----
E
E
G
L
A
K
L
L
L
T
Y
E
A
-------------
A
G
G
R
V
W
P
R
L
A
H
H
I
A
E
R
L
A
F
G
A
V
T
Y
A
L
F
A
L
D
S
G
N
E
E
Y
L
A
A
A
K
A
Q
L
-------------------------------
43
HHSearch
66.41
16%
26
- C1 -
-
5IQI
1
AACA_STAAU
C:
[9-302]
----------------------
A
T
-
N
V
K
A
M
K
Y
L
I
E
H
Y
F
D
N
F-
K
-
V
D
S
I
E
I
I
G
S
G
Y
D
-
S
V
A
Y
L
V
N
----
N
E
Y
I
F
K
T
K
F
S
----
T
N
KK--
K
G
-
F
A
K
E
K
A
I
Y
N
F
L
N
T
-
N
LET
N
--
V
K
I
P
N
I
E
Y
S
Y
---------
I
---
S
D
------
E
L
S
I
L
G
Y
K
E
I
K
G
T
F
L
T
P
E
I
Y
-
S
T
--------
M
S
E
E
E
Q
N
L
L
K
R
D
I
A
S
F
L
R
Q
M
H
G
L
---
D
Y
-
T
-
D
I
S
E
C
---
T
I
-----------------
D
N
K
Q
-------
N
V
L
E
E
Y
I
L
-
L
-
R
E
T
----
I
Y
N
D
L
T
D
-------
I
---
E
K
D
Y
I
E
S
-
F
M
E
R
L
----
N
A
T
T
V
F
E
G
K
K
C
L
-
C
H
N
D
F
S
C
N
H
L
L
L
D
G
N---
N
---
R
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
I
---
Y
L
--
L
-
E
D
S
--
E
EE------
I
----
G
T
N
F
G
E
D
I
L
R
M
Y
G
N
---------------
I
D
I
-
E
K
A
K
E
Y
Q
D
I
V
E
E
Y
Y
P
I
E
T
I
V
Y
G
I
K
N
I
K
Q
E
F
I
E
N
G
R
K
E
I
Y
K
R
T
---------------------------
27
HHSearch
66.04
15%
7
- C1 -
-
5IGI
3
?
A:
[5-297]
---------------------
T
T
A
-
D
T
S
Q
L
Y
A
L
A
A
R
-
H
G
L
--
K
L
H
G
P
L
T
V
N
E
L
G
L
D
-
Y
R
I
V
I
A
T
V
D
D
G
R
R
W
V
L
R
I
P
R
R
----
A
E
V
S
--
A
K
-
V
E
P
E
A
R
V
L
A
M
L
K
N
R
L
---
P
--
F
A
V
P
D
W
R
V
A
N
A
E
L
-
V
A
---
Y
---
P
M
------
L
E
D
S
T
A
-
V
I
Q
P
G
S
S
T
P
D
W
-
V
------------
V
P
Q
D
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
H
A
V
---
P
I
-
S
-
A
A
V
D
A
---
G
M
-------
L
--------
I
R
T
P
T
-------
Q
A
R
Q
K
V
A
D
-
D
-
V
D
R
----
V
R
R
E
F
V
--------
V
---
N
D
K
R
L
H
R
-
W
Q
R
W
L
----
D
D
D
S
S
W
P
D
F
S
V
V
-
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T---
E
---
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
---
A
H
--
L
-
M
-
V
--
F
--------
G
-----
E
E
G
L
A
K
L
L
L
T
Y
E
A
-------------
A
G
G
R
V
W
P
R
L
A
H
H
I
A
E
R
L
A
F
G
A
V
T
Y
A
L
F
A
L
D
S
G
N
E
E
Y
L
A
A
A
K
A
Q
L
-------------------------------
5
PsiBlast_PDB
66.00
18%
-56
- C1 -
-
3W0Q
2
KHYB_ECOLX
A:
[22-236]
--------------------------------------------
V
S
D
L
M
Q
L
S
E
G
E
E
-
S
R
A
F
S
F
D
-
V
G
G
R
G
Y
V
L
R
V
N
-
S
----
C
A
----
D
G
-
F
Y
K
D
R
Y
V
Y
R
H
F
A
S
-
A
---
A
--
L
P
I
P
E
V
L
D
I
G
E
F
-----------
S
E
------
S
L
T
Y
C
I
S
R
R
A
Q
G
V
T
L
Q
D
L
--------------
P
E
T
E
L
P
A
V
L
Q
P
V
A
E
V
M
D
A
I
A
A
A
DLS
Q
T
-
S
-
G
F
G
P
F
---
G
P
-------
Q
-------
G
I
G
Q
Y
T
-------
T
W
R
D
F
I
C
A
-
I
-
A
D
P
H
V
-
Y
H
W
Q
T
V
M
D
D
---
T
--
V
---
S
A
S
V
A
Q
A
-
L
D
E
L
M
L
W
--
A
E
D
C
--
P
E
V
R
H
L
-
V
H
A
D
F
G
S
N
A
V
L
T
D
N
----
G
---
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
F
F
W
--
R
--------------------------------------------------------------------------------------------------------------------------
46
Fugue
65.44
13%
20
- C1 -
-
3JR1
3
?
A:
[14-309]
------------------
N
L
Y
F
Q
G
M
W
K
S
I
S
Q
V
L
A
E
Q
F
G
A
Y
--
Y
-
F
I
K
H
K
E
K
L
Y
S
G
E
M
N
E
I
W
L
I
N
-
D
E
V
Q
T
V
F
V
K
I
N
E
R
----
S
Y
----
R
S
M
F
R
A
E
A
D
Q
L
A
L
L
A
K
-
T
---
N
S
-
I
N
V
P
L
V
Y
---
G
I
G
-
N
----
S
---
Q
G
------
H
S
F
L
L
L
E
A
----------------------
L
N
K
S
K
N
K
Q
S
S
F
T
I
F
A
E
K
I
A
Q
L
H
Q
I
---
Q
G
P
D
-
K
Y
G
L
D
---
F
D
-------
T
-------
W
L
G
P
I
Y
Q
P
N
D
W
QT
S
W
A
K
F
F
S
E
-
N
-
R
I
G
W
Q
-
L
Q
I
C
K
E
K
G
L
---
I
--
F
GN-
I
D
L
I
V
Q
I
-
V
A
D
T
L
S
K
--
H
N
P
K
-----
P
S
I
-
L
H
G
N
L
W
I
E
N
C
I
Q
V
D
----
D
---
K
I
F
-
V
C
N
P
-
A
C
Y
W
G
D
R
E
C
D
I
A
---
F
S
--
S
-
L
-
F
--
E
--------
P
----
F
P
---
T
N
F
Y
Q
R
Y
N
E
-------------
I
Y
P
L
E
-
E
G
Y
L
E
R
K
L
I
Y
Q
L
Y
Y
L
L
N
F
S
Y
R
Y
Y
N
-
K
K
Q
S
Y
V
S
L
T
Q
K
L
I
N
Q
I
L
H
K
-------------------------
1
PsiBlast_PDB
64.92
18%
-51
- C1 -
-
3W0R
2
KHYB_ECOLX
A:
[22-236]
--------------------------------------------
V
S
D
L
M
Q
L
S
E
G
E
E
-
S
R
A
F
S
F
D
-
V
G
G
R
G
Y
V
L
R
V
N
-
S
----
C
A
----
D
G
-
F
Y
K
D
R
Y
V
Y
R
H
F
A
S
-
A
---
A
--
L
P
I
P
E
V
L
D
I
G
E
F
-----------
S
E
------
S
L
T
Y
C
I
S
R
R
A
Q
G
V
T
L
Q
D
L
--------------
P
E
T
E
L
P
A
V
L
Q
P
V
A
E
V
M
D
A
I
A
A
A
DLS
Q
T
-
S
-
G
F
G
P
F
---
G
P
-------
Q
-------
G
I
G
Q
Y
T
-------
T
W
R
D
F
I
C
A
-
I
-
A
D
P
H
V
-
Y
H
W
Q
T
V
M
D
D
---
T
--
V
---
S
A
S
V
A
Q
A
-
L
D
E
L
M
L
W
--
A
E
D
C
--
P
E
V
R
H
L
-
V
H
A
D
F
G
S
A
N
V
L
T
D
N
----
G
---
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
F
F
W
--
R
--------------------------------------------------------------------------------------------------------------------------
31
HHSearch
64.17
17%
34
- C1 -
-
6EF6
2
?
A:
[27-321]
--------------------------
D
V
T
I
A
Q
Q
A
L
T
H
Y
D
V
--
S
D
N
A
S
L
R
L
L
-
N
L
S
E
-
N
A
T
Y
L
V
E
D
G
E
-
H
Q
S
I
L
R
V
H
R
Q
----
D
Y
HQ
P
-
H
E
-
I
E
S
E
L
D
W
L
A
A
L
R
T
D
S
---
D
--
V
T
V
P
T
V
V
P
A
R
D
G
R
-
R
V
V
T
V
D
P
A
D-
V
------
P
R
H
V
V
H
F
E
M
V
G
G
A
E
P
D
E
E
-
S
-
L
----------
T
----
L
D
D
F
Q
T
L
G
R
I
T
A
S
L
H
E
H
---
S
Q
-
R
-
W
-
T
R
P
---
A
G
-------
F
-------
G
-
R
F
S
W
-------
D
W
E
H
C
L
-
G
-
D
-
T
P
R
----
W
G
R
W
Q
D
A
E
GVG
A
--
S
---
E
T
A
L
L
T
R
-
A
Q
D
L
L
H
R
K
L
E
E
Y
G
S
G
P
D
R
Y
G
L
-
I
H
A
D
L
R
L
A
N
L
L
V
D
S
----
S
TPQ
R
T
I
T
V
I
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
G
---
T
A
--
V
S
F
-
I
--
E
--------
H
DPR-
L
G
E
W
Q
E
S
W
V
A
G
Y
R
S
-------------
R
R
E
L
P
-
A
A
D
E
A
M
L
P
S
F
V
F
L
R
R
L
L
L
L
A
W
M
G
S
H
--------------------------------------------