@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : K2EWB2_9BACT: (2019-01-30 )
MQYSERLGSINNAQFQKALDKFNLGLLTKTEKILFGNFGQNIFLTTTKGNFVLRGKPHYSWQFKNEKLMVDLLHEKTNTKVPHPYLIDENTDIFGWSYVIMPRLGGRQLIDKNEQKNLTLKDWKEIASAYAINLIEMHKLTYKYSGKYTDNYIGIKPFSPSFSSWIIQSINILLDKSSSYNKKTTEQDKKWITELLNHRKEALEEPFKPTFTMQDYQITNTLVDKVDGQWIVTGVFDFMESYFGDCEVDLSRMFLKLHENDKELAYIFLNTYLRRKKIRRGFSDRFAIYIVLDRLLVWEWAQRTGKLWWDPDMSLSDWCKRYTKLDKNYLGL
Atome Classification :
(20 SA)
-------.........10-........20.-..-.-------....30.......-.40.......---------.-50---.........----60------..---.......70.-..-..-...80........90--.-----.---------.....----..100....-..-------.110.-......--------.120.......130.....-..140.-..-....150---...----...----..160......---.-170.......180.......190-.......200-.-.-.....210.......220.....--..230.......240.......250.....-----..-260---------------.........270.---.....-------------.280...-------....290.......300.......----------310.....-...320.......330------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------M
Q
Y
S
E
R
LGSI
N
-
N
A
Q
F
Q
K
A
L
D
K
F-NL-G-------LLTKT
E
K
I
L
F
GNF-G
Q
N
I
F
L
T
TTK---------G-
N
----
F
V
L
RGKPH
Y
----
S
-------
W
Q
---FKNE
K
L
M
V
D
L
-
L
H-EK-TNTKVPH
P
Y
L
IDEN---T-----
D
---------
I
FG
W
S
----
Y
V
I
MPRLGG-
R
Q
-------LID-K-NEQKNL--------
T
L
K
D
W
K
E
I
A
S
A
Y
A
I
N
L
I
E
M
-
H
K
L
T
Y
K
-YS-GKYTD
N
----
Y
I
G
----
I
KP----FSP
S
F
S
S
W
I
I
Q
---
S
-
I
N
I
LLDKSSSYNKKT
T
E
Q
D
K
K
W
I
-
T
E
L
L
N
H
R
K
E
A
-
L
-E-EPFKP
T
F
T
M
Q
D
Y
Q
I
T
N
T
L
V
DKVD--G
Q
W
I
V
T
G
V
F
D
F
M
E
S
Y
FGDC
E
V
D
L
S
R
M
F
L
K
L-----HE-N-----------------DK
E
L
A
Y
I
F
L
N
T
Y
L
---
R
R
K
K
I
-------------RRGFSD
R
-------
F
A
I
Y
I
V
L
D
R
L
L
V
W
E
W
A
Q
RTG
K
L
W
W----------DP-DM
S
L
S
-
D
W
C
K
R
Y
T
K
L
D
K
NYLGL------------------
55
Fugue
78.72
16%
-30
* C4 *
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
--------------
T
D
I
T
-
E
D
E
L
R
N
F
L
T
Q
Y
-
D
V
-
G
-------
S
L
T
S
Y
K
G
I
---
A
E
-
N
S
N
F
L
L
H
T
T
K
---------
D
-
P
----
L
I
L
T
L
Y
E
---------------
K
---
K
N
D
L
P
F
F
L
G
L
M
Q
H
L
A
A
-
K
G
L
S
C
P
L
P
L
P
R
K
D
G
EL
L
G
-----
E
---------
L
S
G
R
P
----
A
A
L
I
S
F
L
E
G
M
W
L
----------------
R
K
P
--------
E
A
K
H
C
R
E
V
G
K
A
L
A
-----
A
M
H
L
A
S
E
G
-
F
E
-
I
K
R
P
N
A
----
L
S
---------------------
V
D
---
G
-
W
K
V
L
W
D
K
S
E
E
R
A
D
E
V
E
K
G
L
R
E
E
I
-
R
P
E
I
D
Y
L
A
A
H
-
W
-
P
-
K
D
L
P
A
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
D
------
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
A
W
CFEKD
G
A
-
Y
-----------------
N
V
T
K
G
K
A
L
L
E
G
Y
Q
---
S
V
R
P
L
-------------
S
--
E
A
E
L
-------
E
A
L
P
L
L
S
R
G
S
A
L
R
F
F
L
T
R
L
Y
D
W
L
T
TPAGALVVKK
D
P
-
L
E
Y
L
R
-
K
L
R
F
H
R
T
I
A
N
V
A
E
Y
G
L
A-----------------
48
Fugue
75.75
12%
-103
- C4 -
-
3HAM
3
?
A:
[1-299]
-------------
M
V
N
L
D
-
A
E
I
Y
E
H
L
N
K
Q
I
-
K
I
-
N
-------
E
L
R
Y
L
S
S
----
G
D
-
D
S
D
T
F
L
C
N
E
Q
---------
Y
-
V
----
V
K
V
P
K
R
D
S
V
----
R
-------
I
S
---
Q
K
R
E
F
E
L
Y
R
F
-
L
--
E
N
-
C
K
L
S
Y
Q
I
P
A
V
V
Y
Q
----------------------
S
D
R
----
F
N
I
M
K
Y
I
K
G
-
E
R
-------
I
-
T
-
Y
-
E
Q
Y
H
K
L
--------
S
E
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
-
H
S
I
E
I
D
-
C
S
-
V
S
L
F
S
D
----
A
-------
L
V
----
N
K
K
D
K
F
L
Q
D
K
K
---
L
-
L
I
S
I
L
E
K
E
Q
L
L
T
D
E
M
L
E
H
I
E
T
I
Y
-
E
N
I
L
N
N
A
V
L
F
------
K
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
N
------
N
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
L
L
D
C
S
-----
T
D
-
D
-----------------
F
G
K
E
F
G
R
K
V
L
K
Y
Y
---
Q
H
K
A
--------------
P
E
V
A
E
R
K
-------
A
E
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
E
R
K
D
----------------
R
E
M
L
I
-
K
G
V
S
E
L
L
Q
T
Q
A
E
M
F
I
F
------------------
28
HHSearch
73.78
14%
-13
- C4 -
-
3TDW
1
?
A:
[4-277]
-----------------
N
-
K
L
H
Y
T
T
M
I
M
T
Q
-
F
P
-
D
I------
S
I
Q
S
V
E
S
L
G
E
G
F
R
-
N
Y
A
I
L
V
---
N
---------
G
-
D
----
W
V
F
R
F
P
K
S
Q
Q
G
--
A
-------
D
E
---
L
N
K
E
I
Q
L
L
P
L
-
L
V
-
G
C
-
V
--
K
V
N
I
P
Q
Y
V
Y
I
G
---
K
-----
R
---------
S
D
G
N
P
----
F
V
G
Y
R
K
V
Q
G
-
Q
I
-------
L
G
E
-
D
-
G
M
-
A
V
L
--------
P
D
D
A
K
D
R
L
A
L
Q
L
A
E
F
M
N
E
L
-
S
A
F
P
V
E
-
T
A
-
I
S
A
G
V
P
-------------------
V
T
N
L
K
N
K
I
L
L
---
L
-
S
E
A
V
E
D
Q
V
F
P
L
---
L
D
E
S
L
R
D
Y
L
-
T
L
R
F
Q
S
Y
M
T
H
P
V
-
Y
-
T
R
Y
T
P
R
L
I
H
G
D
L
S
P
D
H
F
L
T
N
L
N
S
--
R
Q
T
P
L
T
G
I
I
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
V
Y
L
L
E
D
C
-----
G
---------------------
E
-
L
F
T
R
Q
V
M
A
Y
R
---
G
E
V
D
L
-------------
D
T
-
H
I
R
K
-------
V
S
L
F
V
T
F
D
Q
V
S
Y
L
L
E
G
-------------------------------------------------------------
32
HHSearch
72.40
15%
-22
- C4 -
-
3F7W
7
?
A:
[2-270]
-------------------
V
N
S
V
A
A
R
V
T
E
L
-
T
G
-
R
-------
E
V
A
A
V
A
E
R
G
H
S
H
R
-
W
H
L
Y
R
V
E
L
A
D
---------
G
T
P
----
L
F
V
K
A
L
P
D
D
APAL
D
-------
G
L
---
F
R
A
E
A
L
G
L
D
W
-
L
G
-
R
S
-
F
--
G
S
P
V
P
Q
V
A
G
W
D
----------------------
D
R
----
T
L
A
M
E
W
V
D
E
-
R
P
-------
P
T
-----------------------
P
E
A
A
E
R
F
G
H
Q
L
A
A
M
-
H
L
A
G
A
E
-
S
F
-
G
A
T
W
D
G
Y
IGP
L
P
M
----
D
N
T
----
P
R
S
T
W
P
E
F
Y
A
E
---
Q
R
I
L
P
Y
L
R
R
A
A
D
R
G
A
-
L
T
P
G
D
V
R
L
V
-
E
K
V
L
D
A
L
D
H
L
-
A
-
G
-
D
P
E
P
P
A
R
I
H
G
D
L
W
N
G
N
V
L
W
Q
D
D
------
G
-
A
V
V
I
D
P
A
-
A
H
G
G
H
R
E
A
D
L
A
M
L
A
L
F
G
---------------------------
L
P
Y
L
D
R
V
R
D
A
Y
N
---
E
V
A
P
L
-------------
A
E
G
W
R
A
R
-------
I
P
L
H
Q
L
H
P
L
L
V
H
V
C
L
F
-------------------------------------------------------------
36
HHSearch
70.71
13%
-21
- C4 -
-
4DCA
1
?
A:
[25-293]
----------------
L
D
-
A
E
I
Y
E
H
L
N
K
Q
I
------------
K
I
N
E
L
R
Y
L
S
S
G
D
D
-
S
D
T
F
L
C
---
N
---------
E
-
Q
----
Y
V
V
K
V
P
K
R
D
S
V
--
R
-------
I
S
---
Q
K
R
E
L
E
L
Y
R
F
-
L
E
-
N
C
K
L
--
S
Y
Q
I
P
A
V
V
Y
Q
S
----------------------
D
R
----
F
N
I
M
K
Y
I
K
G
-
E
R
-------
I
T
Y
-
E
Q
Y
--
H
K
L
--------
S
E
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
-
H
S
I
E
I
D
-
C
S
-
V
S
L
F
S
D
----
A
-------------
L
V
N
K
K
D
K
F
L
-
Q
---
D
-
K
K
L
L
I
S
I
L
E
K
E
Q
-
L
L
T
D
E
M
L
E
H
I
-
E
T
I
Y
E
N
I
L
S
N
-
A
-
V
L
F
K
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
N
N
------
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
L
L
D
C
S
-----
T
D
D
F
-----------------
G
K
E
F
G
R
K
V
L
K
Y
Y
Q
---
H
K
A
P
E
-------------
V
A
E
--
R
K
-------
A
E
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
--------------------------------------------------------------
53
Fugue
68.48
13%
2
- C4 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
T
L
P
A
V
I
S
R
W
L
S
S
V
L
P
G
G
A
-
A
P
E
V
T
V
E
S
G
V
D
-
S
T
-
G
-------
M
S
S
E
T
I
I
L
T
A
R
W
Q
-
Q
D
G
---
R
S
I
Q
---------
Q
-
K
----
L
V
A
R
V
A
P
A
A
----
E
DVPVFPT
Y
R
---
L
D
H
Q
F
E
V
I
R
L
-
V
G
-
E
L
-
T
D
V
P
V
P
R
V
R
W
I
E
T
T
---
G
-----
D
---------
V
L
G
T
P
----
F
F
L
M
D
Y
V
E
G
-
V
V
PPDVMPY
T
F
G
-
D
-
N
W
F
A
D
A
--------
P
A
E
R
Q
R
Q
L
Q
D
A
T
V
A
A
L
A
T
L
-
H
S
I
P
N
----------
A
----
Q
N
T
----
F
S
F
----
L
T
D
T
T
L
H
R
H
F
N
---
W
-
V
R
S
W
Y
D
F
A
V
E
G
I
G
R
S
P
L
L
E
R
--
T
-
F
E
W
L
Q
S
H
W
P
D
-
D
-
A
-
A
A
R
E
P
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
F
------
Q
P
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
W
M
I
F
A
H
-----
R
V
-
F
-----------------
Q
E
L
A
G
L
A
T
L
P
G
L
P
EVM
R
E
D
D
V
-------------
R
A
T
Y
Q
A
L
TG
V
E
L
G
D
L
H
W
F
Y
V
Y
S
G
V
M
W
A
C
V
F
M
R
T
G
A
R
R
V
----------
H
F
G
E
I
E
K
P
-
D
D
V
E
S
L
F
Y
H
A
G
L
M
K
H
L
L
G
EEH-------------
17
HHSearch
68.44
15%
-7
- C4 -
-
6EF6
2
?
A:
[27-317]
-----------------
D
-
V
T
I
A
Q
Q
A
L
T
H
Y
-
D
V
-
S
-------
D
N
A
S
L
R
L
L
-
N
L
S
E
-
N
A
T
Y
L
V
E
D
G
E
---------
H
-
Q
----
S
I
L
R
V
H
R
Q
D
YHQ-
P
-------
H
E
---
I
E
S
E
L
D
W
L
A
A
-
L
R
-
T
D
-
S
--
D
V
T
V
P
T
V
V
P
A
R
---
D
G----
R
R
V
V
T
V
D
P
A
D-
V
P
R
H
----
V
V
H
F
E
M
V
G
G
-
A
E
-------
P
D
E
-
E
-
S
----
L
--------
T
----
L
D
D
F
Q
T
L
G
R
I
T
A
S
L
-
H
E
H
S
Q
R
-
W
T
-
R
P
A
G
F
G
-------------
R
----
F
S
W
D
W
E
H
C
L
G
D
TP-
R
-
W
G
R
W
Q
D
A
E
G
V
G
A
--
S
E
T
A
L
L
T
R
A
-
Q
D
L
L
H
R
K
L
E
E
-
Y
G
S
-
G
P
D
R
Y
G
L
I
H
A
D
L
R
L
A
N
L
L
V
D
S
S
T
---
P
Q
R
T
I
T
V
I
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
G
T
A
V
S
F
I
-----
E
H
-
D
PR---------------
L
G
E
W
Q
E
S
W
V
A
G
Y
R
---
S
R
R
E
L
-------------
P
A
A
D
E
A
M
-------
L
P
S
F
V
F
L
R
R
L
L
L
L
A
W
--------------------------------------------------------------
16
HHSearch
67.61
14%
-35
- C4 -
-
2PPQ
-
KHSE_AGRFC
A:
[6-274]
---------------
D
I
T
-
E
D
E
L
R
N
F
L
T
Q
Y
-
D
V
-
G
-------
S
L
T
S
Y
K
G
I
A
E
----
N
S
N
F
L
L
H
T
T
K
---------
D
-
P
----
L
I
L
T
L
Y
E
K
-----
K
-------
N
D
---
L
P
F
F
L
G
L
M
Q
H
-
L
A
-
A
K
----
G
L
S
C
P
L
P
L
P
R
K
---
D
GEL
L
G
E
---------
L
S
G
R
P
----
A
A
L
I
S
F
L
E
G
-
M
W
-------
L
R
K
-
P
-
E
------------------
A
K
H
C
R
E
V
G
K
A
L
A
A
M
-
H
L
A
S
E
G
-
F
E
-
I
K
R
P
N
A
-------------
L
----
S
V
D
G
W
K
V
L
W
D
K
---
S
-
E
----
E
R
A
D
E
----
V
E
K
G
L
R
E
E
I
-
R
P
E
I
D
Y
L
A
A
H
-
W
-
P
-
K
D
L
P
A
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
D
------
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
A
W
-----
C
F
-
E
KDGAY------------
N
V
T
K
G
K
A
L
L
E
G
Y
Q
---
S
V
R
P
L
-------------
S
E
A
E
L
E
A
-------
L
P
L
L
S
R
G
S
A
L
-------------------------------------------------------------------
26
HHSearch
66.67
15%
-24
- C4 -
-
5IGI
3
?
A:
[6-256]
---------------
T
A
D
-
T
S
Q
L
Y
A
L
A
A
R
H
-
G
L
-
K
-------
L
H
G
P
L
T
V
N
E
L
G
L
D
-
Y
R
I
V
I
A
T
V
D
D
---------
G
R
R
----
W
V
L
R
I
P
R
R
A
E
V
--
S
-------
A
K
---
V
E
P
E
A
R
V
L
A
M
-
L
K
-
N
R
-
L
--
P
F
A
V
P
D
W
R
V
A
N
---
A
-----
E
---------
L
V
A
Y
P
MLED
S
T
A
-
V
I
Q
P
G
-
S
S
-------
T
P
D
-
W
-
V
-------------
V
P
Q
D
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
-
H
A
V
P
I
S
-
A
A
-
V
D
A
G
M
L
----
I
--------
R
----
T
P
T
Q
A
R
Q
K
V
A
D
---
D
-
V
D
R
V
R
R
E
F
V
-----
V
N
D
K
R
L
H
R
W
-
Q
R
W
L
D
D
D
----
S
-
S
-
W
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T
E
-----
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
L
M
V
F
-----
G
---------------------
E
E
G
L
A
K
L
L
L
T
Y
E
---
A
A
G
G
---------------------------------------------------------------------------------------------------------
34
HHSearch
66.30
15%
-21
- C4 -
-
3JR1
3
?
A:
[17-288]
--------------
F
Q
G
M
-
W
K
S
I
S
Q
V
L
A
E
Q
-
F
G
-
A
Y
Y
-----
F
I
K
H
K
E
K
L
Y
S
G
E
M
-
N
E
I
W
L
I
N
D
E
V
---------
Q
-
T
----
V
F
V
K
I
N
E
R
S
Y---
R
-------
S
M
---
F
R
A
E
A
D
Q
L
A
L
-
L
A
-
K
T
-
N
--
S
I
N
V
P
L
V
Y
G
I
G
---------
N
---------
S
Q
G
H
S
----
F
L
L
L
E
A
L
N
K
-
S
K
-------
N
-----
K
------------------
Q
S
S
F
T
I
F
A
E
K
I
A
Q
L
-
H
Q
I
Q
G
P
D
K
Y
-
G
L
D
F
D
T
----
W
L
G
P
I
Y
Q
P
N
D
----
W
Q
T
S
W
A
K
F
F
S
E
N--
R
-
I
G
W
Q
L
Q
I
C
K
E
K
G
--
L
I
F
G
N
I
D
L
I
-
V
Q
I
V
A
---
D
T
-
L
-
S
K
H
N
P
K
P
S
I
L
H
G
N
L
W
I
E
N
C
I
Q
V
D
D
------
K
I
-
F
V
C
N
P
-
A
C
Y
W
G
D
R
E
C
D
I
A
F
S
S
L
F
E
----------------------------
P
F
P
T
N
F
Y
Q
R
Y
N
---
E
I
Y
P
L
-------------
E
E
G
Y
L
E
R
-------
K
L
I
Y
Q
L
Y
Y
L
L
N
F
S
Y
R
Y
-------------------------------------------------------------
27
HHSearch
65.58
15%
-31
- C4 -
-
5IGH
-
?
A:
[6-256]
---------------
T
A
D
-
T
S
Q
L
Y
A
L
A
A
R
H
-
G
L
-
K
-------
L
H
G
P
L
T
V
N
E
L
G
L
D
-
Y
R
I
V
I
A
T
V
D
D
---------
G
R
R
----
W
V
L
R
I
P
R
R
A
E
V
--
S
-------
A
K
---
V
E
P
E
A
R
V
L
A
M
-
L
K
-
N
R
-
L
--
P
F
A
V
P
D
W
R
V
A
N
---
A
-----
E
---------
L
V
A
Y
P
MLED
S
T
A
M
V
I
Q
P
G
-
S
S
-------
T
P
D
-
W
-
V
-------------
V
P
Q
D
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
-
H
A
V
P
I
S
-
A
A
-
V
D
A
G
M
L
----
I
--------
R
----
T
P
T
Q
A
R
Q
K
V
A
D
---
D
-
V
D
R
V
R
R
E
F
V
-----
V
N
D
K
R
L
H
R
W
-
Q
R
W
L
D
D
D
----
S
-
S
-
W
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T
E
-----
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
L
M
V
F
-----
G
---------------------
E
E
G
L
A
K
L
L
L
T
Y
E
---
A
A
G
G
---------------------------------------------------------------------------------------------------------
22
HHSearch
64.70
16%
8
- C4 -
-
5IQI
1
AACA_STAAU
C:
[9-282]
---------------
A
T
N
-
V
K
A
M
K
Y
L
I
E
H
Y
-
F
D
-
N
F------
K
V
D
S
I
E
I
I
G
S
G
Y
D
-
S
V
A
Y
L
V
N
------------
N
-
E
----
Y
I
F
K
T
K
F
S
T
NK--
K
-------
K
G
---
F
A
K
E
K
A
I
Y
N
F
-
L
N
-
T
N
-
L
E
T
N
V
K
I
P
N
I
E
Y
S
Y
---------
I
---------
S
D
E
L
S
----
I
L
G
Y
K
E
I
K
G
-
T
F
-------
L
T
P
-
E
I
Y
--
S
T
M
--------
S
E
E
E
Q
N
L
L
K
R
D
I
A
S
F
L
R
Q
M
-
H
G
L
D
Y
T
-
D
I
-
S
E
C
T
I
---------------------
D
N
K
Q
N
V
L
E
E
---
Y
-
I
L
-
L
R
E
T
I
Y
N
D
---
L
T
D
I
E
K
D
Y
I
-
E
S
F
M
E
R
L
N
A
T
-
T
-
V
-
F
E
G
K
K
C
L
C
H
N
D
F
S
C
N
H
L
L
L
D
G
N
N
-----
R
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
I
Y
L
L
E
D
S
-----
E
E
E
I
-----------------
G
T
N
F
G
E
D
I
L
R
M
Y
G
---
N
--
I
D
-------------
I
E
K
A
K
E
Y
-------
Q
D
I
V
E
E
Y
Y
P
I
E
T
I
V
Y
G
-------------------------------------------------------------
51
Fugue
63.82
17%
8
- C4 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
-----------------
A
-
K
M
R
I
S
P
E
L
K
K
L
-
I
E
-
K
-------
Y
R
C
V
K
D
T
E
G
M
S
P
A
-
K
V
Y
K
L
V
G
E
N
E
---------
N
-
L
----
Y
L
K
M
T
D
S
R
Y
----
K
-------
G
T
TYD
V
E
R
E
K
D
M
M
L
W
-
L
E
-
G
K
-
L
--
P
V
P
K
V
L
H
F
E
R
H
---
D
-----------------
G
W
S
----
N
L
L
M
S
E
A
D
G
-
V
L
-------
C
S
E
-
E
-
Y
E
D
E
------------
Q
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
-
H
S
I
D
I
S
-
D
C
--------------------
P
----
Y
T
N
S
L
D
S
R
L
A
E
---
L
-
D
Y
L
L
N
N
D
L
A
D
V
D
C
E
N
W
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
F
L
K
T
-
E
-
K
-
P
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
------
G
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
-----
R
E
-
D
-----------------
I
G
E
--
E
Q
Y
V
E
L
F
F
---
D
L
L
G
I
-------------
K
P
D
-
W
E
K
-------
I
K
Y
Y
I
L
L
D
E
L
F
------------------------------------------------------------------
21
HHSearch
63.23
15%
7
- C4 -
-
5IQC
2
AACA_STAAU
A:
[5-283]
-----------
Y
D
D
N
A
T
N
-
V
K
A
M
K
Y
L
I
E
H
Y
-
F
D
-
N
F------
K
V
D
S
I
E
I
I
G
S
G
Y
D
-
S
V
A
Y
L
V
---
N
---------
N
-
E
----
Y
I
F
K
T
K
F
S
T
NK--
K
-------
K
G
---
Y
A
K
E
K
A
I
Y
N
F
-
L
N
-
T
N
-
L
E
T
N
V
K
I
P
N
I
E
Y
S
Y
---------
I
---------
S
D
E
L
S
----
I
L
G
Y
K
E
I
K
G
-
T
F
-------
L
T
P
E
I
-
Y
--
S
T
M
--------
S
E
E
E
Q
N
L
L
K
R
D
I
A
S
F
L
R
Q
M
-
H
G
L
D
Y
T
-
D
I
-
S
E
C
T
I
D
-------------
N
----
K
Q
N
V
L
E
E
-
Y
I
L
---
L
-
R
E
T
I
Y
N
D
-------
L
T
D
I
E
K
D
Y
I
-
E
S
F
M
E
R
L
N
A
T
-
T
-
V
-
F
E
G
K
K
C
L
C
H
N
D
F
S
C
N
H
L
L
L
D
G
N
N
-----
R
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
I
Y
L
L
E
D
S
-----
E
E
E
I
-----------------
G
T
N
F
G
E
D
I
L
R
M
Y
G
---
N
--
I
D
-------------
I
E
K
A
K
E
Y
-------
Q
D
I
V
E
E
Y
Y
P
I
E
T
I
V
Y
G
I
------------------------------------------------------------
23
HHSearch
63.13
16%
34
- C- -
-
3N4U
-
?
A:
[2-283]
--------------
R
T
Y
T
-
F
D
Q
V
E
K
A
I
E
Q
L
-
Y
P
-
D
F------
T
I
N
T
I
E
I
S
G
E
G
N
D
-
C
I
A
Y
E
I
---
N
---------
R
-
D
----
F
I
F
K
F
P
K
H
S
R
G
--
S
-------
T
N
---
L
F
N
E
V
N
I
L
K
R
-
I
H
-
N
K
-
L
--
P
L
P
I
P
E
V
V
F
T
G
---
M
P
S
---
E
---------
T
Y
Q
M
S
----
F
A
G
F
T
K
I
K
G
-
V
P
-------
L
T
P
-
L
-
L
L
-
N
N
L
--------
P
K
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
-
H
S
I
N
I
S
-
G
F
-
K
S
N
L
---------------------
V
L
D
F
R
E
K
I
N
E
---
D
-
N
K
K
I
K
K
L
L
S
R
E
---
L
K
G
P
Q
M
K
K
V
-
D
D
F
Y
R
D
I
L
E
N
-
E
I
Y
-
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
K
--
N
--
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
M
E
D
D
-----
E
E
-
Y
-----------------
G
M
E
F
V
S
K
I
L
N
H
Y
K
---
H
K
D
I
P
-------------
T
--
V
L
E
K
-------
Y
R
M
K
E
K
Y
W
S
F
E
K
I
I
Y
G
K
E
Y
G
---------------------------------------------------------
29
HHSearch
61.47
18%
7
- C4 -
-
5IWU
2
?
A:
[3-257]
----------------
K
D
-
I
K
Q
V
I
E
I
A
K
K
H
-
N
L
F
L
-------
K
E
E
T
I
Q
F
N
E
S
G
L
D
-
F
Q
A
V
F
A
Q
D
N
N
---------
G
I
D
----
W
V
L
R
L
P
R
R
E
D
V
--
M
-------
P
R
---
T
K
V
E
K
Q
A
L
D
L
-
V
N
-
K
Y
A
I
--
S
F
Q
A
P
N
W
I
I
Y
T
----------------------
E
E
----
L
I
A
Y
K
K
L
D
G
-
V
P
-------
A
G
T
-
I
-
D
--
H
N
I
GNYIWEID
I
N
N
V
P
E
L
F
H
K
S
L
G
R
V
L
A
E
L
-
H
S
I
P
S
N
-
K
A
-
A
A
L
D
L
V
----
V
--------
H
----
T
P
E
E
A
R
M
S
M
K
Q
---
R
-
M
D
A
V
R
A
K
F
G
-----
V
G
E
N
L
W
N
R
W
-
Q
A
W
L
N
D
D
----
D
-
M
-
W
P
K
K
T
G
L
I
H
G
D
V
H
A
G
H
T
M
I
D
K
D
A
-----
N
V
T
G
L
I
D
W
T
E
A
K
V
T
D
V
S
H
D
F
I
F
N
Y
R
A
F
--------------------------
G
E
E
G
L
E
A
L
I
L
A
Y
K
---
E
I
G
G
Y
--------------------------------------------------------------------------------------------------------
19
HHSearch
60.38
13%
-7
- C4 -
-
1ZYL
-
SRKA_ECOLI
A:
[5-275]
----------
A
F
T
F
Q
T
L
H
-
P
D
T
I
M
D
A
L
F
E
H
-
G
I
-
R
-------
V
D
S
G
L
T
P
L
-
N
S
Y
E
-
N
R
V
Y
Q
F
Q
D
E
D
---------
R
R
R
----
F
V
V
K
F
Y
R
P
E
RWT-
A
-------
D
Q
---
I
L
E
E
H
Q
F
A
L
Q
-
L
V
-
N
D
----
E
V
P
V
A
A
P
V
A
F
N
---
G
QT
L
L
-
N
---------
H
Q
G
F
Y
----
F
A
V
F
P
S
V
G
G
-
R
Q
-------
F
E
A
-
D
-
N
------------------
I
D
Q
M
E
A
V
G
R
Y
L
G
R
M
-
H
Q
T
G
R
K
-
Q
L
-
F
I
H
R
P
T
-------------
I
----
G
L
N
E
Y
L
I
E
P
R
K
---
L
-
F
E
D
----
A
T
L
I
P
S
G
L
K
A
A
F
L
K
A
T
-
D
E
L
I
A
A
V
T
A
H
-
W
-
R
-
E
D
F
T
V
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
--------
G
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
L
L
N
G
D
-----
K
A
-
E
-----------------
Q
R
M
Q
L
E
T
I
I
E
A
Y
E
---
E
F
S
E
F
-------------
D
T
A
E
I
G
L
-------
I
E
P
L
R
A
M
R
L
V
-------------------------------------------------------------------
49
Fugue
59.94
15%
39
- C4 -
-
3JR1
3
?
A:
[14-309]
------------
N
L
Y
F
Q
G
M
W
K
S
I
S
Q
V
L
A
E
Q
F
G
A
-
Y
-------
Y
F
I
K
H
K
E
K
L
Y
S
G
E
M
N
E
I
W
L
I
N
D
E
V
---------
Q
-
T
----
V
F
V
K
I
N
E
R
S
----
Y
-------
R
S
M
--
F
R
A
E
A
D
Q
L
A
L
-
L
A
-
K
T
-
N
S
I
N
V
P
L
V
Y
G
I
G
N
S
---
Q
-----
G
------------
H
S
----
F
L
L
L
E
A
L
N
K
-
S
------------------------------
K
N
K
Q
S
S
F
T
I
F
A
E
K
I
A
Q
L
-
H
Q
I
Q
G
P
-
D
K
Y
G
L
D
F
D
T
----
W
L
G
----
P
I
Y
Q
P
N
D
W
Q
T
S
W
A
K
F
F
S
E
NR
I
G
-
W
Q
L
Q
I
C
K
E
K
G
L
I
F
G
N
I
D
L
I
V
Q
I
V
-
A
D
T
L
S
K
H
N
P
---------
K
P
S
I
L
H
G
N
L
W
I
E
N
C
I
Q
V
D
D
-------
K
I
F
V
C
N
P
A
-
C
Y
W
G
D
R
E
C
D
I
A
F
S
----------
S
-
L
-----------------
F
E
P
F
P
T
N
F
Y
Q
R
Y
N
---
E
I
Y
P
L
-------------
E
E
G
Y
L
E
R
-------
K
L
I
Y
Q
L
Y
Y
L
L
N
F
S
Y
R
Y
Y
N
K
---------------------
K
Q
-
S
Y
V
S
L
T
Q
K
L
I
N
Q
I
L
H
K
------------------
57
Fugue
59.75
13%
4
- C4 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
---------
S
A
F
T
F
Q
T
L
H
-
P
D
T
I
M
D
A
L
F
E
H
-
G
I
-
R
-------
V
D
S
G
L
T
P
L
-
N
S
Y
E
-
N
R
V
Y
Q
F
Q
D
E
D
---------
R
-
R
R
F
V
V
K
F
Y
R
P
E
R
W
T
----
A
-------
D
Q
---
I
L
E
E
H
Q
F
A
L
Q
-
L
V
-
N
D
--
E
V
P
V
A
A
P
V
A
F
N
G
Q
---
T
L
L
---
N
---------
H
Q
G
F
Y
----
F
A
V
F
P
S
V
G
G
-
R
Q
-------
F
E
A
-
D
-
N
------------------
I
D
Q
M
E
A
V
G
R
Y
L
G
R
M
-
H
Q
T
G
R
K
-
Q
L
------------------
F
I
H
----
R
P
T
I
G
L
N
E
Y
L
I
---
E
-
P
R
K
L
F
E
D
A
T
L
I
P
S
G
L
K
A
A
F
L
K
A
T
-
D
E
L
I
A
A
V
T
A
H
-
W
-
R
-
E
D
F
T
V
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
G
--------
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
L
L
N
G
D
-----
K
A
-
E
-----------------
Q
R
M
Q
L
E
T
I
I
E
A
Y
E
---
E
F
S
E
F
-------------
D
T
A
E
I
G
L
-------
I
E
P
L
R
A
M
R
L
V
Y
Y
L
A
W
L
M
R
---
R
W
A
----------
D
P
-
A
F
P
K
N
F
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
EPPLQLTPMY
37
HHSearch
59.48
15%
-4
- C4 -
-
5FTG
11
CHKA_HUMAN
A:
[4-341]
-------------
P
E
P
R
T
-
R
R
R
A
Y
L
W
C
K
E
F
-
L
P
-
G
AWRGLRE
D
E
F
H
I
S
V
I
R
G
G
L
S
-
N
M
L
F
Q
C
S
L
P
D
TTATLGDEP
R
-
K
----
V
L
L
R
L
Y
G
--------------
E
A
---
M
V
L
E
S
V
M
F
A
I
-
L
A
-
E
R
----
S
L
G
-
P
K
L
Y
G
I
F
---------
P
-------------
Q
----
G
R
L
E
Q
F
I
P
S
-
R
R
-------
L
D
T
-
E
-
E
----
L
-----------
S
L
P
D
I
S
A
E
I
A
E
K
M
A
T
F
-
H
G
M
K
M
P
-
F
N
-
K
E
P
K
W
L
----
F
--------
G
----
T
M
E
K
Y
L
K
E
V
L
R
---
I
----
K
F
T
E
E
S
R
I
K
-
K
L
H
K
L
L
S
Y
N
L
-
P
L
E
L
E
N
L
R
S
L
-
L
-
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
E
G
R
EN
S
E
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
W
-----
M
Y
-
D
YSYEKYPF
F
R
A
N
IRKYP
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
---
P
A
F
Q
N
DFENLS
T
E
E
K
S
I
I
K
E
E
M
L
L
E
-------
V
N
R
F
A
L
A
S
H
F
L
W
-----------------------------------------------------------------