@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : K5XP12_9PROT: (2019-01-30 )
MSAAEMGMAETADLRTRLAPLFPGREISLRSAAAPVASPLHRAVASACVLAQPDGADPLFLKLAHPDMQDDLLDTDGAAARLAARAGVAPALVLARPGLLGFAYLALPWRYARTGDLQPPATLAAVLAAKKRLHEGDNLGRRFCPFTRIAQLQAQAEAAQVPLPAETAPLLRQAALIQQALIASGMDLRFCHNHAAASNIMLNGSQMMLVDFDIGGDNDPWYDVGALLNEVCDFDAPRRAAIEAYAGRCDEALFARCRLYGAVDDLMWGLWGFTRAVTAPRDGIEFWKYGTWRLFQARTTMTMRDFELWLRTV
Atome Classification :
(20 SA)
--------------------------.........10........20....---.....30........40........50.-------..-------.--------....60.......-.70-.-........80........-90....----------....100.......110.......-.120.......130..---------------...--.--.--140.---------------.--......150--------......------------.-------.--------160---------.-----.-.-----------..-------.-------.--------..170.......180--------------.---------........190.......200----.---.-------.----....210.......220.......230-----------.------------------.---------.------------------.------------------.-----..---------..240.--....---------..---------------250---------.........260.......270...-....280........290......---.300.......310.-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------------M
S
A
A
E
MGM
A
E
T
A
D
L
R
T
R
LAP-LFPG---
R
E
I
S
LRSAAA
P
V
A
S
P
L
H
R
A
V
A
S
A
C
V
LAQ-------PD-------G--------AD
P
L
F
L
K
LAHPDM-QD--D-LLDTDG
A
A
A
R
L
A
A
RAGVA-
P
A
L
V
L
A----------RPG
L
L
G
F
A
Y
L
A
L
P
W
R
-YARTGDLQ-P
P
A
T
L
A
A
V
L
A
A
K
K
R
LH---------------EGD--N--L--
G
R
-R---------------F--C
P
F
T
R
I
A
Q
---------
L
Q
AQAE------------A-------A--------Q-----------V-----P-L-----------PA-------
E
-------
T
--------
A
P
L
L
R
Q
A
A
L
I
Q
Q
A
----------------
L
---------
I
ASG
M
D
L
R
F
CHNHAAAS
N
I
M
L----N---G-------
S
----
Q
M
M
L
V
D
F
D
IGGDNDP
W
Y
D
V
G
A
L
L
N
E
-------------V------------------C---------D------------------F------------------D-----A
P
---------
R
R
A
A
I
E
--
A
Y
AG---------R
C
---------------
D
-----------
E
A
L
F
A
R
C
R
L
Y
G
A
V
D
D
L
M
W
G
L
W
G
F
T
R
-AVTAP-RDGI
E
F
WKYG
T
W
R
L
F
Q
A
R---T
T
M
T
M
R
D
F
E
L
W
L
RTV-
21
HHSearch
86.01
25%
-32
- C8 -
-
3DXQ
-
?
B:
[5-296]
------------------------------------
E
A
R
A
K
L
A
A
I
P
-
M
L
A
G
---
Y
T
G
P
L
E
---------
R
L
G
G
L
T
N
L
V
F
R
A
---------------------------
G
D
L
C
L
R
I
P
-----------
N
R
A
N
E
A
V
A
A
R
E
A
A
K
A
G
V
S
-
P
E
V
L
H
V
DP--------
A
T
G
V
M
V
T
R
Y
I
-
A
G
-
A
Q
T
M
S
P
E
K
F
K
T
R
P
G
S
P
A
R
A
G
E
A
F
R
K
L
H
---------------
G
S
G
--
A
--
V
--
F
P
F
R
---------------
F
--
E
L
F
A
M
I
D
D
---------
Y
L
K
V
L
S
------------
T
-------
K
--------
N
-----------
V
-----
T
-
L
-----------
P
A
-------
G
-------
Y
--------
H
D
V
V
R
E
A
G
G
V
R
S
A
----------------
L
---------
A
A
H
P
L
P
L
A
A
C
H
C
D
P
L
C
E
N
F
L
D
----
T
---
G
-------
E
----
R
M
W
I
V
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
D
L
S
V
E
-------------
G
------------------
K
---------
F
------------------
N
------------------
A
-----
N
Q
---------
D
E
E
L
M
R
--
A
Y
F
G
---------
G
E
A--------------
R
-----------
P
A
E
R
G
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
I
Q
-
L
A
N
D
N
--
P
V
D
D
F
R
A
Y
A
D
G
R
F
A
R
C
K
---
A
L
M
E
T
P
E
F
S
R
H
L
A
A
--
22
HHSearch
79.67
25%
-15
- C- -
-
3DXQ
-
?
A:
[5-296]
------------------------------------
E
A
R
A
K
L
A
A
I
P
-
M
L
A
G
---
Y
T
G
P
L
E
---------
R
L
G
G
L
T
N
L
V
F
R
A
---------------------------
G
D
L
C
L
R
I
P
G
K
-----Y-
I
-
N
R
A
N
E
A
V
A
A
R
E
A
A
K
A
G
V
S
-
P
E
V
L
H
V
DP--------
A
T
G
V
M
V
T
R
Y
I
-
A
G
-
A
Q
T
M
S
P
E
K
F
K
T
R
P
G
S
P
A
R
A
G
E
A
F
R
K
L
H
---------------
G
S
G
--
A
--
V
--
F
P
F
R
---------------
F
--
E
L
F
A
M
I
D
D
---------
Y
L
K
V
L
S
-----------------------------
N
-----------
V
-----
T
-
L
-----------
P
A
-------
G
-------
Y
--------
H
D
V
V
R
E
A
G
G
V
R
S
A
----------------
L
---------
A
A
H
P
L
P
L
A
A
C
H
C
D
P
L
C
E
N
F
L
D
----
T
---
G
-------
E
----
R
M
W
I
V
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
D
L
S
V
E
-------------
G
------------------
K
---------
F
------------------
N
------------------
A
-----
N
Q
---------
D
E
E
L
M
R
--
A
Y
F
G
---------
G
E
A--------------
R
-----------
P
A
E
R
G
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
I
Q
-
L
A
N
D
N
--
P
V
D
D
F
R
A
Y
A
D
G
R
F
A
R
C
K
---
A
L
M
E
T
P
E
F
S
R
H
L
A
A
--
1
PsiBlast_PDB
73.57
28%
-54
- C- -
-
3DXQ
-
?
A:
[103-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
P
A
R
A
G
E
A
F
R
K
L
H
G
--------------
S
G
A
--
V
--
F
--
P
F
-
R
---------------
F
--
E
L
F
A
M
I
D
D
---------
Y
L
K
V
L
S
-----------------------------
N
-----------
V
-----
T
-
L
-----------
P
A
-------
G
-------
Y
--------
H
D
V
V
R
E
A
G
G
V
R
S
A
----------------
L
---------
A
A
H
P
L
P
L
A
A
C
H
C
D
P
L
C
E
N
F
L
D
----
T
---
G
-------
E
----
R
M
W
I
V
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
D
L
S
V
E
--------------------------------
G
---------
K
------------------
F
------------------
N
-----
A
N
---------
Q
D
E
E
L
M
R
A
Y
F
G
G
---------
E
A
---------------
R
-----------
P
A
E
R
G
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
I
Q
L
A
N
D
N
P
-
V
D
--
D
F
R
A
Y
A
D
G
R
F
A
R
C
K
---
A
L
M
E
T
P
E
F
S
R
H
L
A
A
V
-
31
HHSearch
73.14
16%
-21
- C8 -
-
5FTG
11
CHKA_HUMAN
A:
[14-375]
--------------------------------------
L
W
C
K
E
F
L
P
G
A
W
R
G
LRE
D
E
F
H
I
S
V
--------
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
------
P
D
-------
T
TATLGDE-
P
R
K
V
L
L
R
L
Y
G
--------
E
-
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
L
G
-
P
K
L
Y
G
I
----------
F
P
Q
G
R
L
E
Q
F
I
-
P
S
-
R
-
R
L
D
T
E
E
L
S
-
L
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
---------------
G
M
K
--
M
--
P
--
F
N
-
K
---------------
E
PK
W
L
F
G
T
M
E
K
---------
Y
L
K
E
V
L
------------
R
-------
I
--------
K
-----------
F
-----
T
-
E
-----------
E
S
-------
R
-------
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
L
----------------
L
---------
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
----
L
---
E
GRENSEK
Q
----
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
-------------
W
------------------
M
---------
Y
------------------
D
YSYEKYPF
F
R
A
N
IRKYPT
K
-----
K
Q
---------
Q
L
H
F
I
S
--
S
Y
L
P
---------
A
F
QNDFENLS
T
E
E
K
S
I
I
K
-----------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
-
A
K
I
S
--
S
I
E
F
G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
F
---
H
Q
K
R
K
-----------
29
HHSearch
72.17
14%
-16
- C8 -
-
3C5I
3
?
D:
[20-365]
---------------------------------------
I
C
L
E
K
V
P
-
E
W
N
H
FTE
D
N
L
R
V
K
Q
--------
I
L
--
L
T
N
Q
L
F
E
V
G
L
------
K
E
-------
E
T
A
N
N
Y
NSI
R
T
R
V
L
F
R
I
Y
G
K
H
V
-
D
E
--
L
Y
N
T
I
S
E
F
E
V
Y
K
T
M
S
K
Y
K
I
A
-
P
Q
L
L
N
T
----------
F
N
G
G
R
I
E
E
W
L
-
Y
G
-
D
-
P
L
R
I
D
D
L
K
-
N
P
T
I
L
I
G
I
A
N
V
L
G
K
F
H
---------------
T
L
S
--
R
--
K
--
R
H
-
L
PEHWDRT--------
P
--
C
I
F
K
M
M
E
K
---------
W
K
N
Q
L
F
------------
K
-------
Y
--------
K
-----------
N
IE---
K
-
Y
-----------
N
C
-------
D
-------
I
--------
H
K
Y
I
K
E
S
D
K
F
I
K
F
----------------
M
K
V
Y
S
KS---
D
N
L
A
N
T
I
V
F
C
H
N
D
L
Q
E
N
N
I
I
N
----
T
---
N
-------
K
----
C
L
R
L
I
D
F
E
Y
S
G
F
N
F
L
A
T
D
I
A
N
F
F
I
E
-------------
T
------------------
S
---------
I
DYSVSSYPF
F
E
I
D
KKKYI
S
------------------
Y
-----
E
N
---------
R
K
L
F
I
T
--
A
Y
L
S
---------
N
Y
---------------
L
DKVVPT
P
K
L
I
-
D
E
I
L
E
A
V
E
V
Q
A
L
G
A
H
L
L
W
G
F
W
S
I
I
R
-
G
Y
Q
T
K
S
Y
N
E
F
D
F
F
L
Y
A
E
Q
R
L
K
M
Y
D
D
Q
K
E
Y
L
I
S
N
N
I
I
-------
45
Fugue
71.59
15%
-4
- C8 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
--------G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
G
A
W
K
-
T
V
P
L
---
E
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
S
E
V
Y
P
P
I
-------
R
N
-------
E
--------
P
N
K
V
L
L
R
V
Y
F
N
P
E
-
T
E
--
S
-
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
H
L
G
-
P
K
L
Y
G
I
----------
F
S
G
--
G
R
L
E
E
Y
I
P
S
R
-
P
L
S
C
H
E
I
S
-
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
---------------
Q
L
E
VP
I
--
W
--
K
E
-
P
---------------
D
--
Y
L
C
E
A
L
Q
R
---------
W
L
K
Q
L
T
------------
G
-------
T
V
DAE
H
---
R
-----------
F
-----
D
-
L
-----------
P
E
-------
E
CGVSSVN
C
--------
L
D
L
A
R
E
L
E
F
L
R
A
H
----------------
I
---------
S
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
----
P
-----------
K
----
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
IDYDIDEAPF
Y
K
------------------
I
---------
Q
------------------
T
------------------
E
NFPE
N
D
Q
---------
M
L
E
F
F
L
--
N
Y
L
R
---------
E
Q
---------------
G
NTRENE
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
-
V
E
L
S
P
-
V
G
------
F
G
F
A
D
Y
G
R
D
R
---
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A
-
46
Fugue
70.07
13%
2
- C8 -
-
2QG7
-
?
A:
[50-458]
YPITESNLRILEGED
R
S
E
K
A
K
E
L
L
K
K
Y
V
S
N
V
F
E
N
E
K
T
L
Y
I
Y
C
K
Y
V
M
-
L
H
Y
G
---
K
D
L
V
N
P
N
E
V
D
S
L
E
F
Q
I
I
N
G
T
N
I
L
I
K
V
K
D
-------
M
S
-------
K
--------
Q
A
K
Y
L
I
R
L
Y
G
P
T
D
-
E
I
--
I
-
N
R
E
R
E
K
K
I
S
C
I
L
Y
N
K
N
I
A
-
K
K
I
Y
V
F
----------
F
T
N
--
G
R
I
E
E
F
M
D
G
Y
-
A
L
S
R
E
D
I
K
-
N
P
K
F
Q
K
L
I
A
K
N
L
K
L
L
H
D
IKLN
E
N
L
Y
K
E
L
Q
V
T
Q
K
V
--
P
--
G
--
T
R
-
P
---------------
S
--
F
L
W
N
T
I
W
K
---------
Y
F
H
L
L
N
------------
E
-------
E
--------
R
K
KICSFDAKA
N
I
-----
L
-
K
-----------
L
I
-------
D
-------
F
--------
D
V
L
R
D
S
I
V
E
V
E
S
L
----------------
C
---------
K
R
E
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
----
T
VGE
G
-------
D
----
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
E
-------------
Y
------------------
A
---------
G
------------------
F
NCDWDLTPS---------
K
-----
E
E
---------
E
Y
H
F
I
M
--
H
Y
L
G
TDD
E
-----
E
L
---------------
I
-----------
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
-----
G
-
M
H
S
F
D
F
I
N
Y
G
M
T
R
L
T
A
S
C
---
L
P
I
F
R
S
K
V
--------
24
HHSearch
68.08
16%
-15
- C8 -
-
1NW1
-
CKA2_CAEEL
A:
[74-419]
------------------------------------------------------
E
H
L
R
I
S
R
--------
I
K
G
G
M
S
N
M
L
F
L
C
R
L
------
S
E
VYPPIRN
E
--------
P
N
K
V
L
L
R
V
Y
F
N
P
E
-
T
E
--
S
-
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
H
L
G
-
P
K
L
Y
G
I
----------
F
S
G
G
R
L
E
E
Y
I
-
P
S
-
R
-
P
L
S
C
H
E
I
S
-
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
---------------
Q
L
E
--
V
--
P
--
I
W
-
K
EP-------------
D
--
Y
L
C
E
A
L
Q
R
---------
W
L
K
Q
L
T
------------
G
-------
T
--------
V
-----------
D
AE
H
R
F
D
-
L
-----------
P
E
ECGVSSV
N
-------
C
--------
L
D
L
A
R
E
L
E
F
L
R
A
H
----------------
I
---------
S
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
----
P
---
K
------------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
-------------
W
------------------
T
---------
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
-----
D
Q
---------
M
L
E
F
F
L
--
N
Y
L
R
---------
E
Q
---------------
G
NTRENE
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
-
V
E
L
S
--
P
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
---
K
H
K
-------------
23
HHSearch
67.88
16%
-18
- C8 -
-
1NW1
-
CKA2_CAEEL
B:
[74-419]
------------------------------------------------------
E
H
L
R
I
S
R
--------
I
K
G
G
M
S
N
M
L
F
L
C
R
L
------
S
E
VYPPIRN
E
--------
P
N
K
V
L
L
R
V
Y
F
N
P
E
-
T
E
--
S
-
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
H
L
G
-
P
K
L
Y
G
I
----------
F
S
G
G
R
L
E
E
Y
I
-
P
S
-
R
-
P
L
S
C
H
E
I
S
-
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
---------------
Q
L
E
--
V
--
P
--
I
W
-
K
EP-------------
D
--
Y
L
C
E
A
L
Q
R
---------
W
L
K
Q
L
T
------------
G
-------
T
--------
V
-----------
D
AE
H
R
F
D
-
L
-----------
P
E
ECGVSSV
N
-------
C
--------
L
D
L
A
R
E
L
E
F
L
R
A
H
----------------
I
---------
S
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
----
P
---
K
------------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
-------------
W
------------------
T
---------
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
-----
D
Q
---------
M
L
E
F
F
L
--
N
Y
L
R
---------
E
Q
---------------
G
NTRENE
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
-
V
E
L
S
--
P
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
---
K
H
K
-------------
60
SP3
67.23
15%
-8
- C8 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
----------------G
M
K
E
L
L
S
T
MD
L
D
T
D
A
N
T
I
P
E
L
K
E
R
A
H
M
L
C
A
-
R
F
L
G
---
G
A
W
K
T
V
P
L
E
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
S
EVYPP
I
R
-------
N
--------
E
P
N
K
V
L
L
R
V
Y
F
N
P
E
T
E
--
S
-
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
H
L
G
-
P
K
L
Y
G
I
----------
F
S
G
G
R
L
E
E
Y
I
P
S
--
R
-
P
L
S
C
H
E
I
S
-
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
---------------
Q
L
E
--
V
PI
W
--
K
E
-
P
---------------
D
--
Y
L
C
E
A
L
Q
R
---------
W
L
K
Q
L
T
G
T
V
DAE
H
R
F
D
L
P
E
-------
E
--------
C
-----------
G
-----
V
-
S
-----------
S
V
-------
N
-------
C
--------
L
D
L
A
R
E
L
E
F
L
R
A
H
----------------
I
---------
S
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
----
P
-----------
K
----
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
-------------
W
T
IDYDIDEAPF
Y
K
I
Q
TEN
F
---------
P
------------------
E
------------------
N
-----
D
Q
---------
M
L
E
F
F
L
--
N
Y
L
R
---------
E
Q
---------------
G
NTRENE
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
-
V
E
L
S
P
-
V
G
-
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
---
K
H
K
------
Q
L
L
K
N
L
A
32
HHSearch
66.85
16%
4
- C8 -
-
5FUT
10
CHKA_HUMAN
A:
[14-375]
--------------------------------------
L
W
C
K
E
F
L
P
G
A
W
R
G
LRE
D
E
F
H
I
S
V
--------
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
------
P
D
-------
T
TATLGDE-
P
R
K
V
L
L
R
L
Y
G
------G
A
E
-
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
L
G
-
P
K
L
Y
G
I
----------
F
P
Q
G
R
L
E
Q
F
I
-
P
S
-
R
-
R
L
D
T
E
E
L
S
-
L
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
---------------
G
M
K
--
M
--
P
--
F
N
-
K
---------------
E
PK
W
L
F
G
T
M
E
K
---------
Y
L
K
E
V
L
------------
R
-------
I
--------
K
-----------
F
-----
T
-
E
-----------
E
S
-------
R
-------
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
L
----------------
L
---------
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
----
L
---
E
GRENSEK
Q
----
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
-------------
W
------------------
M
---------
Y
------------------
D
YSYEKYPF
F
R
A
N
IRKYPT
K
-----
K
Q
---------
Q
L
H
F
I
S
--
S
Y
L
P
---------
A
F
QNDFENLS
T
E
E
K
S
I
I
K
-----------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
-
A
K
I
S
--
S
I
E
F
G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
F
---
H
Q
K
R
K
-----------
34
HHSearch
65.48
13%
-32
- C8 -
-
3MES
2
?
B:
[54-408]
------------------------------------
I
I
G
I
C
R
K
N
I
P
-
G
W
K
E
INE
S
Y
I
E
V
K
Q
--------
I
F
S
G
L
T
N
Q
L
F
V
V
S
I
------
V
N
-------
E
LK------
H
P
R
I
L
F
R
I
Y
G
K
H
V
-----
F
Y
D
S
K
V
E
L
D
V
F
R
Y
L
S
N
I
N
I
A
-
P
N
I
I
A
D
----------
F
P
E
G
R
I
E
E
F
I
-
D
G
-
E
-
P
L
T
T
K
Q
L
Q
-
L
T
H
I
C
V
E
V
A
K
N
M
G
S
L
H
---------------
I
I
N
--
S
--
K
--
R
A
-
D
FPSRFDKE-------
P
--
I
L
F
K
R
I
Y
L
---------
W
R
E
E
A
K
------------
I
-------
Q
--------
V
-----------
S
K
NN--
Q
I
D
-----------
K
E
-------
L
-------
Y
--------
S
K
I
L
E
E
I
D
Q
L
E
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
L
---------
Y
S
P
A
F
S
L
V
F
A
H
N
D
L
Q
E
N
N
L
L
Q
----
T
---
Q
-------
N
----
N
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
A
D
I
A
N
Y
F
C
E
-------------
Y
------------------
I
---------
Y
------------------
D
YCSEKQPY
F
K
F
K
YEDYPC
E
-----
E
L
---------
R
K
L
F
I
S
--
V
Y
L
S
---------
Q
T
---------------
L
QEQVMPSQ
Q
I
V
H
I
M
T
K
A
V
E
V
F
T
L
I
S
H
I
T
W
G
L
W
S
I
A
--------
S
V
E
F
D
F
T
E
Y
A
N
T
R
F
T
H
Y
L
---
Q
K
K
K
E
-----------
50
Fugue
63.85
21%
-38
- C8 -
-
4WW7
1
BUD32_YEAST
A:
[4-257]
----------------------------
E
F
I
D
K
V
S
S
Y
L
T
P
D
V
D
I
A
P
-
I
S
Q
G
---
A
A
I
V
F
T
T
T
T
H
P
Y
L
P
R
A
-------------------
K
D
-------
S
--------
H
Q
K
Y
I
I
K
Y
------
R
P
--
R
-
T
L
N
E
S
R
L
L
A
K
L
Y
L
I
P
G
L
C
-
V
P
Q
L
I
A
----------
C
D
P
Y
N
G
F
I
W
L
E
F
L
--------------------------------------------
G
E
--
D
--
L
PG
G
H
-
G
---------------
F
--
S
N
L
K
N
F
L
W
---------
M
H
D
Q
D
------------------------------------------------
P
-
Y
-----------
S
D
-------
L
-------
V
--------
A
T
T
L
R
K
V
G
R
Q
I
G
L
----------------
L
---------
H
W
N
D
----
Y
C
H
G
D
L
T
S
S
N
I
V
L
----
V
---
R
-------
D
GA
R
W
T
P
H
L
I
D
F
G
L
G
S
V
S
N
L
V
E
D
K
G
V
D
L
Y
V
-------------
L
E
-----------------
R
---------
A
------------------
I
------------------
L
-----
S
T
---------
H
S
K
H
A
E
--
K
Y
N
A
---------
W
I
---------------
M
-----------
E
G
F
E
E
V
Y
R
E
Q
G
---------------------
A
K
G
A
K
K
L
K
E
V
T
K
R
F
E
E
V
R
---
L
R
G
R
K
R
----------
33
HHSearch
63.43
13%
-18
- C8 -
-
3MES
3
?
A:
[54-408]
------------------------------------
I
I
G
I
C
R
K
N
I
P
-
G
W
K
E
INE
S
Y
I
E
V
K
Q
--------
I
F
S
G
L
T
N
Q
L
F
V
V
S
I------
V
N
-------
E
LK------
H
P
R
I
L
F
R
I
Y
G
K
H
V
--
K
--
F
Y
D
S
K
V
E
L
D
V
F
R
Y
L
S
N
I
N
I
A
-
P
N
I
I
A
D
----------
F
P
E
G
R
I
E
E
F
I
-
D
G
-
E
-
P
L
T
T
K
Q
L
Q
-
L
T
H
I
C
V
E
V
A
K
N
M
G
S
L
H
---------------
I
I
N
--
S
--
K
--
R
A
-
D
FPSRFDKE-------
P
--
I
L
F
K
R
I
Y
L
---------
W
R
E
E
A
K
------------
I
-------
Q
--------
V
-----------
S
K
NN---I
D
-----------
K
E
-------
L
-------
Y
--------
S
K
I
L
E
E
I
D
Q
L
E
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
L
---------
Y
S
P
A
F
S
L
V
F
A
H
N
D
L
Q
E
N
N
L
L
Q
----
T
---
Q
-------
N
----
N
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
A
D
I
A
N
Y
F
C
E
-------------
Y
------------------
I
---------
Y
------------------
D
YCSEKQPY
F
K
F
K
YEDYPC
E
-----
E
L
---------
R
K
L
F
I
S
--
V
Y
L
S
---------
Q
T
---------------
L
QEQVMPSQ
Q
I
V
H
I
M
T
K
A
V
E
V
F
T
L
I
S
H
I
T
W
G
L
W
S
I
A
---------
V
E
F
D
F
T
E
Y
A
N
T
R
F
T
H
Y
L
---
Q
K
K
K
E
-----------
25
HHSearch
61.02
14%
-15
- C8 -
-
2QG7
-
?
D:
[116-453]
---------------------------------------------------------------------
I
N
G
G
-
T
N
I
L
I
K
V
K
D------
M
S
-------
K
--------
Q
A
K
Y
L
I
R
L
Y
G
P
K
T
-
D
-----
N
R
E
R
E
K
K
I
S
C
I
L
Y
N
K
N
I
A
-
K
K
I
Y
V
F
F---------
T
N
G
-
R
I
E
E
F
M
-
D
G
-
Y
-
A
L
S
R
E
D
I
K
-
N
P
K
F
Q
K
L
I
A
K
N
L
K
L
L
H
---------------
D
I
K
--
L
--
N
--
E
N
-
L
YKELQVTQKVPGTRP
S
--
F
L
W
N
T
I
W
K
---------
Y
F
H
L
L
N
------------
E
-------
E
--------
R
-----------
K
-----
K
-
I
CSFDAKANILK
L
I
-------
D
-------
F
--------
D
V
L
R
D
S
I
V
E
V
E
S
L
----------------
C
---------
K
R
E
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
----
T
---
V
G------
D
----
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
E
-------------
Y
------------------
A
GFNCDWDLT
P
------------------
S
------------------
K
-----
E
E
---------
E
Y
H
F
I
M
--
H
Y
L
G
---------
T
D
---------------
D
EELI-------
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
-
G
M
H
S
--
S
-
D
F
D
F
I
N
Y
G
M
T
R
L
T
A
S
C
---
L
P
I
-------------
27
HHSearch
59.88
17%
-4
- C8 -
-
4R78
2
?
A:
[37-304]
--------------------------------------------------
E
---
E
V
L
S
V
E
Q
--------
L
-
G
G
M
T
N
Q
N
Y
L
A
K
T
------
T
N
-----------------
K
Q
Y
I
V
K
F
F
G
K
G
T
-
E
K
L-
I
-
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
L
G
L
D
-
V
K
N
Y
L
F
DI--------
E
A
G
I
K
V
N
E
Y
I
-
E
S
-
A
I
T
L
D
S
T
--
S
-
I
K
T
K
F
D
K
I
A
P
I
L
Q
T
I
H
---------------
T
S
A
--
K
--
E
--
L
R
G
E
---------------
F
--
A
P
F
E
E
I
K
K
---------
Y
E
S
L
I
E
------------
E
-------
Q
--------
I
-----------
P
-------------------
Y
A
-------
N
-------
Y
--------
E
S
V
R
N
A
V
F
S
L
E
K
R
----------------
L
---------
A
D
L
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
----
S
---
P
Q------
G
----
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
E
-------------
S
------------------
E
---------
F
------------------
T
------------------
S
-----
Q
E
---------
E
E
T
F
L
S
--
H
Y
E
S
---------
D
Q
---------------
T
-----------
P
V
S
H
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
-
E
E
Q
G
-----
E
D
F
G
D
Y
G
V
N
R
Y
Q
R
A
V
---
K
G
L
A
S
Y
G
---------
7
PsiBlast_PDB
59.85
22%
-49
- C8 -
-
2IG7
-
CHKB_HUMAN
A:
[154-374]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
S
R
-
P
L
K
T
Q
E
L
R
-
E
P
V
L
S
A
A
I
A
T
K
M
A
Q
F
H
---------------
G
M
E
--
M
----------------------------
P
F
T
K
E
P
H
W
L
F
G
T
M
E
R
Y
L
K
Q
I
Q
D
------------
L
-------
P
------------------------------------------MN
L
L
---
E
-------
M
--------
Y
S
L
K
D
E
M
G
N
L
R
K
L
----------------
L
---------
E
S
T
P
S
P
V
V
F
C
H
N
D
I
Q
E
G
N
I
L
L
LS--------------------
L
M
L
V
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
W
------------
V
------------------
Y
---------
D
------------------
Y
THEEWPFYKARPT-----
D
-----
Y
P
T
Q
E
Q
Q
L
H
F
I
R
H
Y
L
A
E
--
A
K
K
G
E
T
L
S
Q
E
E
Q
R
K
L
---------------
E
-----------
E
D
L
L
V
E
V
S
R
Y
A
L
A
S
H
F
F
W
G
L
W
S
I
L
Q
-
A
S
M
S
----
T
I
E
F
-------------------------------
5
PsiBlast_PDB
59.48
23%
-42
- C8 -
-
3LQ3
2
CHKB_HUMAN
A:
[154-374]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
S
R
-
P
L
K
T
Q
E
L
R
-
E
P
V
L
S
A
A
I
A
T
K
M
A
Q
F
H
---------------
G
M
E
------------------------------
M
P
F
T
K
E
P
H
W
L
F
G
T
M
E
R
Y
L
K
Q
I
Q
D
------------
L
-------
P
--------
P
-----------
T
-----
G
-
L
-----------
P
E
MN
L
L
---
E
-------
M
--------
Y
S
L
K
D
E
M
G
N
L
R
K
L
----------------
L
---------
E
S
T
P
S
P
V
V
F
C
H
N
D
I
Q
E
G
N
I
L
L
LSEP------------
D
----
S
L
M
L
V
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
W
------------
V
------------------
Y
---------
D
------------------
Y
THEEWPFYKARPT-----
D
-----
Y
P
T
Q
E
Q
Q
L
H
F
I
R
H
Y
L
A
E
--
A
K
K
G
E
T
L
S
Q
E
E
Q
R
K
L
---------------
E
-----------
E
D
L
L
V
E
V
S
R
Y
A
L
A
S
H
F
F
W
G
L
W
S
I
L
Q
-
A
S
M
S
----
T
I
E
F
-------------------------------
42
HHSearch
59.08
13%
-27
- C8 -
-
2Q83
4
COTI_BACSU
A:
[23-308]
----------------------------------------
A
E
N
V
L
Q
-
G
W
D
V
---
Q
A
E
K
I
D
V
--------
I
Q
----
A
L
V
W
K
V
H
T
------
D
S
-----------------
G
A
V
C
L
K
R
I
H
R
P
E
-
K
---
K
--
A
L
F
S
I
F
A
Q
D
Y
L
A
K
K
G
M
N
V
P
G
I
L
P
N
KKGSL
Y
S
K
H
G
S
F
L
F
V
V
Y
D
W
I
-
E
G
-
R
-
P
F
E
L
---
T
-
V
K
Q
D
L
E
F
I
M
K
G
L
A
D
F
H
---------------
T
A
S
--
V
--
G
--
Y
Q
-
P
P
NG------------
V
--
P
I
F
T
K
L
G
R
---------
W
P
N
H
Y
T
------------
K
R
C
K
Q
M
E
T
W
K
L
M
A
E
A
E
K
E
-----------
D
-----
P
-
F
S
Q
L
Y
-------
L
Q
-------
E
-------
I
--------
D
G
F
I
E
D
G
L
R
I
K
D
R
----------------
L
L
Q
ST
Y
V
P
W
T
E
Q
L
K
K
S
P
N
L
C
H
Q
D
Y
G
T
G
N
T
L
L
----
G
---
E
N------
E
----
Q
I
W
V
I
D
L
D
T
V
S
F
D
L
P
I
R
D
L
R
K
M
I
I
P
-------------
L
------------------
L
---------
D
TTGVW-------------
D
------------------
D
-----
E
T
---------
F
N
V
M
L
N
--
A
Y
E
S
---------
R
A
P
L
-------------
T
-----------
E
E
Q
K
Q
V
M
F
I
D
M
L
F
P
Y
E
-----------------------------------------------------
28
HHSearch
58.86
17%
-0
- C8 -
-
4R7B
-
?
A:
[37-304]
--------------------------------------------------
E
---
E
V
L
S
V
E
Q
--------
L
-
G
G
M
T
N
Q
N
Y
L
A
K
T
------
T
N
-----------------
K
Q
Y
I
V
K
F
F
G
K
G
T
-
E
K
L-
I
-
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
L
G
L
D
-
V
K
N
Y
L
F
DI--------
E
A
G
I
K
V
N
E
Y
I
-
E
S
-
A
I
T
L
D
S
T
--
S
-
I
K
T
K
F
D
K
I
A
P
I
L
Q
T
I
H
---------------
T
S
A
--
K
--
E
--
L
R
G
E
---------------
F
--
A
P
F
E
E
I
K
K
---------
Y
E
S
L
I
E
------------
E
-------
Q
--------
I
-----------
P
-------------------
Y
A
-------
N
-------
Y
--------
E
S
V
R
N
A
V
F
S
L
E
K
R
----------------
L
---------
A
D
L
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
----
S
---
P
Q------
G
----
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
E
-------------
S
------------------
E
---------
F
------------------
T
------------------
S
-----
Q
E
---------
E
E
T
F
L
S
--
H
Y
E
S
---------
D
Q
---------------
T
-----------
P
V
S
H
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
-
E
E
Q
G
-----
E
D
F
G
D
Y
G
V
N
R
Y
Q
R
A
V
---
K
G
L
A
S
Y
G
---------