@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M8A5X5_TRIUA: (2019-01-31 )
MRTVAAPAPALAEVACFSRDLCKELVKEWSSLDSSCFSISTVSGGITNMLLKVSVKEGSDSESSVTVRLYGPNTDLVIDRERELQGSGLGYLEYLRMEWFRHSSMLGHYHLQVYTQRLLFCTHRCMETGEPAINASANNMKEPRIAAEIAKQLQKFHQVDIPGSKEPQLWNDIFKFLKKASVLKFEDNEKQKRYETISFREIQDEVKELKDLSDLLHAPVVFAHNDLLSGNLMLNDLEEKLYFIDFEYGSYSYRGFDIANHFNEYAGFECDYNLYPDKDVQYHFFRNYLSDRPSELKNRLFASICEKRNVGYLAFVQYKVQEQDLDDLYTETNTFRLASHLYWALWALIQARVSPIDFDYLGYFFLRRHVVPNRKLYNL
Atome Classification :
(35 SA)
------------------------...------......10........20-------...-.-..-.-.30........40........50.......----.----60---..----.......70.......--..80........90........100.......110.......--120.......130.......140.......150.......160------------.....--------------.-------.-.--------------.170.....-----..180..---..--.----.----.190.......200.......210---------------........220.......230.----.-----.-..-----..240.......250.......260---------..---------.---------.---------...270-------.........280.......290.......300.......310.......320.......330.......340.......350.......360.....--..370.......---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------MRT------VAAP
A
P
A
L
A
E
V
A
C
F
S
R
D
L
-------
C
K
E
-
L
-
V
K
-
E
-
W
S
SLDSS
C
F
S
I
S
TVSGG
I
T
N
M
L
L
K
V
S
VKEG----S----D----SE----
S
S
V
T
V
R
L
Y-GPNT
D
L
V
--
I
DRERELQGSG
L
G
Y
L
E
Y
L
R
M
E
W
F
R
HSSM
L
G
H
Y
H
L
Q
V
Y
T
Q
R
L
L
--
F
C
T
H
R
C
METGEPAINASANNMKE
P
R
I
A
A
E
I
A
K
Q
L
Q
K
F
H
QVD--------------IPGSK--------------E-------
P
-
Q
--------------
L
W
N
D
I
F
K
F
L
-----
K
KA
S
V
L
K---FE--D----N----E
K
Q
K
R
YET
I
S
F
R
E
I
Q
D
E
V
K
E
L
K
D
----------------
L
S
D
L
L
HA
P
V
V
F
AHNDLLSGNL
M
----
L
-----
N
-
D
L-----EE
K
L
Y
F
I
D
F
EYGS
Y
S
Y
RG
F
D
I
A
N
H
F
---------
N
E
---------Y---------A---------GFEC---------DYNLYPDKD
V
Q
Y
H
F
F
R
N
Y
L
SD
R
P
S
E
L
K
N
R
L
F
A
S
I
C
E
KRNV
G
Y
L
A
F
V
Q
Y
KVQEQ
D
L
D
D
L
YTET
N
T
F
R
L
A
S
H
L
Y
W
A
L
W
A
L
I
Q
ARVSPI
D
F
D
Y
L
G
Y
F
F
L
R
--
R
HVVPNRKLYNL---
40
Fugue
79.25
29%
11
- C6 -
-
2QG7
-
?
A:
[50-458]
YPITESNLRILEGED
R
S
E
K
A
K
E
L
L
K
K
Y
------
V
S
N
V
F
E
N
E
K
T
L
Y
I
Y
C
K
Y
V
-------
M
L
H
-
Y
-
G
K
-
D
-
L
V
N
P
N
E
V
-
D
S
L
E
F
Q
I
I
N
G
T
N
I
L
I
K
V
K
D
-------
M
----
S
----
K
Q
----
A
K
Y
L
I
R
L
Y
-
G
P
-
T
D
E
I
--
I
N
R
E
R
E
K
K
I
S
C
I
L
Y
------------------
N
K
N
I
A
K
K
I
Y
V
--
F
F
T
N
G
R
I
E
E
F
M
D
G
Y
A
L
S
R
E
D
I
K
N
P
K
F
Q
K
L
I
A
K
N
L
K
L
L
H
D
I
K
--------------
L
N
E
N
L
--------------
Y
-------
K
-
E
L
Q
V
T
QKVPGTRPSF
L
W
N
T
I
W
K
Y
F
-----
H
L
L
N
E
E
R
K
KI
C
S
--
F
----
D
----
A
K
A
N
I
L
K
L
I
D
F
D
V
L
R
D
S
I
V
E
V
E
S
----------------
L
C
K
R
E
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
----
N
-----
T
V
G
E
-----
G
D
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
---------
N
E
---------
Y
---------
A
---------
G
F
N
C
---------
D
W
D
L
T
P
S
K
E
E
E
Y
H
F
I
M
H
Y
L
G
T
D
D
----------------------------
E
E
L
I
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
---
G
M
H
S
F
D
F
I
N
Y
G
M
T
R
--
L
T
A
S
C
L
P
I
F
R
S
K
V--
41
Fugue
78.20
27%
3
- C6 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-----------------G
M
K
E
L
L
S
T
M
D
------
L
D
T
D
A
N
T
I
P
E
L
K
E
R
A
H
M
L
-------
C
A
R
-
F
-
L
G
G
A
-
W
K
T
V
P
L
E
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
S
E
V
----
Y
----
P
----
P
I
RNEP
N
K
V
L
L
R
V
Y
F
N
P
E
T
E
S
H
--
L
V
A
E
S
V
I
F
T
L
L
S
E
R
H
L
G
P
K
L
Y
G
I
F
S
G
G
R
L
E
E
Y
I
----------------------
P
S
R
P
L
S
C
H
E
I
S
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
Q
L
E
--------------
V
P
I
W
K
--------------
E
-------
P
D
Y
--------------
L
C
E
A
L
Q
R
W
L
-----
K
Q
L
T
G
T
V
---
D
A
--
E
----
H
R
F
D
L
P
E
E
C
G
V
S
S
V
N
C
L
D
L
A
R
E
L
E
F
L
R
A
----------------
H
I
S
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
----
L
-----
P
-
K
--------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
---------
I
E
---------
W
T
IDYDIDEA
P
---------
F
Y
K
I
---------
Q
T
E
N
F
P
E
N
D
Q
M
L
E
F
F
L
N
Y
L
R
E
Q
G
N
---------------------
T
R
E
N
E
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A--
65
HHSearch
77.12
31%
13
- C6 -
-
5FUT
10
CHKA_HUMAN
A:
[5-376]
----------------------------------------
E
P
R
T
R
R
R
A
Y
L
W
-------
C
K
E
-
F
-
L
P
G
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
TATL
G
----
D
----
E
P
----
R
K
V
L
L
R
L
Y
-
G
------G
A
E
A
M
V
L
E
S
V
M
F
A
-----
I
L
A
E
R
S
L
G
-
P
K
L
Y
G
I
F
P
Q
G
--------------
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
K
W
--------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
-----
L
-
E
G
RENSE
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
---------
W
---------
M
---------
Y
D
Y
S
YEKYPF
F
R
A
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
-----------
L
------
S
T
E
E
K
S
I
I
K
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
A
Q
A
R
--
F
D
A
Y
F
H
Q
K
R
K
L
----
64
HHSearch
76.35
31%
18
* C6 *
-
5FTG
11
CHKA_HUMAN
A:
[5-376]
----------------------------------------
E
P
R
T
R
R
R
A
Y
L
W
-------
C
K
E
-
F
-
L
P
G
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
TATL
G
----
D
----
E
P
----
R
K
V
L
L
R
L
Y
-
G
--------
E
A
M
V
L
E
S
V
M
F
A
-----
I
L
A
E
R
S
L
G
-
P
K
L
Y
G
I
F
P
Q
G
--------------
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
K
W
--------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
-----
L
-
E
G
RENSE
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
---------
W
---------
M
---------
Y
D
Y
S
YEKYPF
F
R
A
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
-----------
L
------
S
T
E
E
K
S
I
I
K
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
A
Q
A
R
--
F
D
A
Y
F
H
Q
K
R
K
L
----
19
PsiBlast_PDB
76.12
27%
-42
- C6 -
-
2QG7
-
?
A:
[100-445]
-----------------------------------------------------------
K
D
-
L
-
V
N
-
P
--
N
E
V
D
S
L
E
F
Q
I
--
I
N
G
--
T
N
I
L
I
K
V
---
K
D
----
M
----
S
----
K
Q
----
A
K
Y
L
I
R
L
Y
-
G
P
-
T
D
E
I
--
I
N
R
E
R
E
K
K
I
S
C
I
------------------
L
Y
N
K
N
I
A
K
K
I
Y
V
--
F
F
T
N
G
R
I
E
E
F
M
D
G
Y
A
L
S
R
E
D
I
K
N
P
K
F
Q
K
L
I
A
K
N
L
K
L
L
H
D
I
K
LN
E
N
L
Y
K
E
L
Q
V
T
QK
V
P
G
T
R
--------------
P
-------
S
-
F
--------------
L
W
N
T
I
W
K
Y
F
H
L
L
N
E
E
R
K
K
I
C
S
---
F
D
------------
A
K
A
N
I
L
K
L
I
D
F
D
V
L
R
D
S
I
V
E
V
E
S
----------------
L
C
K
R
E
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
T
VG---------
E
-----
G
D
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
---------
N
E
---------
Y
---------
A
---------
G
F
N
C
---------
D
W
D
L
T
P
S
K
E
E
E
Y
H
F
I
M
H
Y
L
G
T
D
D
E
E
L
I
N
Q
L
I
R
----------------------------
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
G
M
H
S
---
F
D
F
I
N
Y
G
M
T
R
-----------------
61
HHSearch
75.83
23%
-72
- C6 -
-
3MES
3
?
A:
[52-410]
---------------------------------------------
E
I
I
I
G
I
-------
C
R
K
-
N
-
I
P
-
G
-
W
K
E
I
N
E
S
Y
I
E
V
K
Q
I
F
S
G
L
T
N
Q
L
F
V
V
S
I
V
N
E
---------
L
----
K
H
----
P
R
I
L
F
R
I
Y
-
G
K
H
V
-
K
F
--
Y
D
S
K
V
E
L
D
V
F
R
-----
Y
L
S
N
I
N
I
A
-
P
N
I
I
A
D
F
P
E
G
--------------
R
I
E
E
F
I
D
G
E
P
L
T
T
K
Q
L
Q
L
T
H
I
C
V
E
V
A
K
N
M
G
S
L
H
I
I
N
--------------
S
K
R
A
D
--------------
F
PSRFDKE
P
-
I
--------------
L
F
K
R
I
Y
L
W
R
-----
E
E
A
K
I
Q
V
---
S
K
--
N
-----------
N
--
I
D
K
E
L
Y
S
K
I
L
E
E
I
D
Q
L
E
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
L
Y
S
P
A
F
S
L
V
F
A
H
N
D
L
Q
E
N
N
L
L
----
Q
-----
T
-
Q
-------
N
N
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
A
D
I
A
N
Y
F
---------
C
E
---------
Y
---------
I
---------
Y
D
Y
C
SEKQPY
F
K
F
K
Y
E
D
Y
P
C
E
E
L
R
K
L
F
I
S
V
Y
L
S
Q
T
L
Q
E
Q
---------------------
V
M
P
S
Q
Q
I
V
H
I
M
T
K
A
V
E
V
F
T
L
I
S
H
I
T
W
G
L
W
S
I
A
------
V
E
F
D
F
T
E
Y
A
N
T
R
--
F
T
H
Y
L
Q
K
K
K
E
L
I
---
62
HHSearch
74.53
23%
-67
- C6 -
-
3MES
2
?
B:
[52-410]
---------------------------------------------
E
I
I
I
G
I
-------
C
R
K
-
N
-
I
P
-
G
-
W
K
E
I
N
E
S
Y
I
E
V
K
Q
I
F
S
G
L
T
N
Q
L
F
V
V
S
I
V
N
E
---------
L
----
K
H
----
P
R
I
L
F
R
I
Y
-
G
K
H
V
--
F
--
Y
D
S
K
V
E
L
D
V
F
R
-----
Y
L
S
N
I
N
I
A
-
P
N
I
I
A
D
F
P
E
G
--------------
R
I
E
E
F
I
D
G
E
P
L
T
T
K
Q
L
Q
L
T
H
I
C
V
E
V
A
K
N
M
G
S
L
H
I
I
N
--------------
S
K
R
A
D
--------------
F
PSRFDKE
P
-
I
--------------
L
F
K
R
I
Y
L
W
R
-----
E
E
A
K
I
Q
V
---
S
K
--
N
-----------
N
-
Q
I
D
K
E
L
Y
S
K
I
L
E
E
I
D
Q
L
E
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
L
Y
S
P
A
F
S
L
V
F
A
H
N
D
L
Q
E
N
N
L
L
----
Q
-----
T
-
Q
-------
N
N
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
A
D
I
A
N
Y
F
---------
C
E
---------
Y
---------
I
---------
Y
D
Y
C
SEKQPY
F
K
F
K
Y
E
D
Y
P
C
E
E
L
R
K
L
F
I
S
V
Y
L
S
Q
T
L
Q
E
Q
---------------------
V
M
P
S
Q
Q
I
V
H
I
M
T
K
A
V
E
V
F
T
L
I
S
H
I
T
W
G
L
W
S
I
A
-----
S
V
E
F
D
F
T
E
Y
A
N
T
R
--
F
T
H
Y
L
Q
K
K
K
E
L
I
---
28
Blastp_CBE
73.32
32%
10
- C6 -
-
2CKQ
1
CHKA_HUMAN
B:
[46-373]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
-
G
A
I
----------------
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGR-----------
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
YDYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
56
HHSearch
73.12
27%
8
- C6 -
-
1NW1
-
CKA2_CAEEL
B:
[50-422]
-----------------------------------------
P
E
L
K
E
R
A
H
M
L
-------
C
A
R
-
F
-
L
G
-
G
A
W
K
T
V
P
L
E
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
S
E
V
----
Y
PPIR
N
----
E
P
----
N
K
V
L
L
R
V
Y
-
F
N
P
E
T
-
E
--
S
H
L
V
A
E
S
V
I
F
T
-----
L
L
S
E
R
H
L
G
-
P
K
L
Y
G
I
F
S
G
G
--------------
R
L
E
E
Y
I
P
S
R
P
L
S
C
H
E
I
S
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
Q
L
E
--------------
V
P
I
W
K
--------------
E
-------
P
-
D
Y
-------------
L
C
E
A
L
Q
R
W
L
-----
K
Q
L
T
G
T
V
---
D
A
--
E
H
R
F
D
L
----
P
E
E
C
G
V
S
S
V
N
C
L
D
L
A
R
E
L
E
F
L
R
A
----------------
H
I
S
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
----
L
-----
P
-
K
--------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
---------
I
E
---------
W
---------
T
---------
I
D
Y
D
IDEAPF
Y
K
I
Q
T
E
N
F
P
E
N
D
Q
M
L
E
F
F
L
N
Y
L
R
E
Q
G
N
T
R
--------------------
E
N
-
E
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
V
G
F
G
F
A
D
Y
G
R
D
R
--
L
S
L
Y
F
K
H
K
Q
L
L
----
30
SP3
73.11
24%
15
- C6 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-----------------------G
M
K
E
L
L
S
T
MD
L
D
T
D
A
N
T
I
P
E
L
K
E
R
A
H
M
L
-------
C
A
R
-
F
L
G
G
-
A
-
W
K
T
V
P
L
E
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
S
E
V
----
Y
----
P
PIRN
E
P
----
N
K
V
L
L
R
V
Y
-
F
-
N
P
E
T
E
--
S
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
H
-----------
L
G
P
K
L
Y
G
I
F
S
G
G
---------
R
L
E
E
Y
I
P
S
R
P
L
S
C
H
E
I
S
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
Q
L
E
--------------
V
P
I
W
K
--------------
E
-------
P
-
D
Y
-------------
L
C
E
A
L
Q
R
W
L
-----
K
Q
L
T
G
T
V
---
D
A
--
E
----
H
R
F
D
L
P
E
E
C
G
V
S
S
V
N
C
L
D
L
A
R
E
L
E
F
L
R
A
----------------
H
I
S
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
----
L
-----
P
---------
K
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
---------
I
E
---------
W
---------
T
IDYDIDEAP
F
Y
K
I
---------
Q
T
E
N
F
P
E
N
D
Q
M
L
E
F
F
L
N
Y
L
R
E
Q
G
---------------------
N
T
R
E
N
E
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
V
G
F
G
F
A
D
Y
G
R
D
R
--
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA
55
HHSearch
73.01
27%
7
- C6 -
-
1NW1
-
CKA2_CAEEL
A:
[50-422]
-----------------------------------------
P
E
L
K
E
R
A
H
M
L
-------
C
A
R
-
F
-
L
G
-
G
A
W
K
T
V
P
L
E
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
S
E
V
----
Y
PPIR
N
----
E
P
----
N
K
V
L
L
R
V
Y
-
F
N
P
E
T
-
E
--
S
H
L
V
A
E
S
V
I
F
T
-----
L
L
S
E
R
H
L
G
-
P
K
L
Y
G
I
F
S
G
G
--------------
R
L
E
E
Y
I
P
S
R
P
L
S
C
H
E
I
S
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
Q
L
E
--------------
V
P
I
W
K
--------------
E
-------
P
-
D
Y
-------------
L
C
E
A
L
Q
R
W
L
-----
K
Q
L
T
G
T
V
---
D
A
--
E
H
R
F
D
L
----
P
E
E
C
G
V
S
S
V
N
C
L
D
L
A
R
E
L
E
F
L
R
A
----------------
H
I
S
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
----
L
-----
P
-
K
--------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
---------
I
E
---------
W
---------
T
---------
I
D
Y
D
IDEAPF
Y
K
I
Q
T
E
N
F
P
E
N
D
Q
M
L
E
F
F
L
N
Y
L
R
E
Q
G
N
T
R
--------------------
E
N
-
E
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
V
G
F
G
F
A
D
Y
G
R
D
R
--
L
S
L
Y
F
K
H
K
Q
L
L
----
22
Blastp_CBE
72.72
32%
17
- C6 -
-
5AFV
4
CHKA_HUMAN
B:
[16-361]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
------------------
G
A
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
EQ
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
WMYDYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
2
PsiBlast_PDB
72.70
31%
8
- C6 -
-
3F2R
1
CHKA_HUMAN
A:
[39-384]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
-
G
-------------------
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
YDYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
-
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
20
PsiBlast_PDB
72.64
29%
18
- C6 -
-
2IG7
-
CHKB_HUMAN
A:
[49-379]
------------------------------------------------
R
D
A
E
R
R
A
Y
Q
W
C
R
E
Y
L
-
G
G
-
A
-
W
R
R
V
Q
P
E
E
L
R
V
Y
P
V
S
G
G
L
S
N
L
L
F
R
C
S
L
P
D
H
LPSV
G
----
E
----
E
P
----
R
E
V
L
L
R
L
Y
-
G
A
I
------------
L
Q
G
V
D
S
L
V
L
E
S
V
M
F
A
I
L
A
E
R
S
L
----
G
P
Q
L
Y
G
---
V
--
F
P
E
G
R
-
L
E
Q
Y
I
P
S
R
P
L
K
T
Q
E
L
R
E
P
V
L
S
A
A
I
A
T
K
M
A
Q
F
H
G
M
E
--------------
M
P
F
T
K
--------------
E
-------
P
-
H
W-------------
L
F
G
T
M
E
R
Y
L
-----
K
Q
I
Q
D
L
P
-------------------
M
N
L
L
E
M
Y
S
---
L
K
D
E
M
G
N
L
R
K
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
I
Q
E
G
N
I
L
----
L
-----
L
-
S
---------
L
M
L
V
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
W
V
YDYTH
E
E
---------
W
---------
P
---------
F
Y
K
A
---------
R
P
T
D
Y
P
T
Q
E
Q
Q
L
H
F
I
R
H
Y
L
A
----
E
A
K
K
G
E
T
L
S
Q
E
E
Q
R
----------
K
L
E
E
----
D
L
L
V
E
V
S
R
Y
A
L
A
S
H
F
F
W
G
L
W
S
I
L
Q
A
S
M
S
T
I
E
F
G
Y
L
D
Y
---------------------
57
HHSearch
72.56
32%
6
- C6 -
-
2QG7
-
?
D:
[102-456]
-------------------------------------------------------------------
L
-
V
N
P
N
E
V
D
S
L
E
F
Q
I
I
N
G
G
-
T
N
I
L
I
K
V
K
D
M
S
---------------
K
Q
----
A
K
Y
L
I
R
L
Y
-
G
P
K
T
D
-----
N
R
E
R
E
K
K
I
S
C
-----
I
L
Y
N
K
N
I
A
-
K
K
I
Y
V
F
F
T
N
G
R
--------------
I
E
E
F
M
D
G
Y
A
L
S
R
E
D
I
K
N
P
K
F
Q
K
L
I
A
K
N
L
K
L
L
H
D
I
K
--------------
L
N
E
N
L
YKELQVTQKVPGTR
P
-------
S
-
F
--------------
L
W
N
T
I
W
K
Y
F
-----
H
L
L
N
E
E
R
---
K
K
IC
S
----
F
D---
A
K
A
N
I
L
K
L
I
D
F
D
V
L
R
D
S
I
V
E
V
E
S
----------------
L
C
K
R
E
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
----
N
-----
T
-
V
G
------
D
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
---------
N
E
---------
Y
---------
A
---------
G
F
N
C
---------
D
W
D
L
T
P
S
K
E
E
E
Y
H
F
I
M
H
Y
L
G
T
D
D
E
E
----------------------------
L
I
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
G
M
H
S
S
-
D
F
D
F
I
N
Y
G
M
T
R
--
L
T
A
S
C
L
P
I
F
R
S
----
17
PsiBlast_PDB
72.40
31%
-42
- C6 -
-
2CKP
1
CHKA_HUMAN
A:
[46-373]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
-----------------
P
----
R
K
V
L
L
R
L
Y
---------------------
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
EQ
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
--------------------
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
-----------------------
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
YDYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
18
PsiBlast_PDB
72.09
31%
12
- C6 -
-
2CKQ
1
CHKA_HUMAN
A:
[46-373]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
A
T
L
G
D
----
E
P
----
R
K
V
L
L
R
L
Y
-
G
-------------------
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
------
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
Y
DYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
6
PsiBlast_PDB
71.60
31%
17
- C6 -
-
5AFV
6
CHKA_HUMAN
A:
[16-361]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
------------------
G
A
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W
-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
Y
DYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
23
Blastp_CBE
71.57
32%
21
- C6 -
-
4BR3
2
CHKA_HUMAN
B:
[21-366]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
---
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
------------------
G
A
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W
-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
Y
DYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
12
PsiBlast_PDB
71.57
31%
18
- C6 -
-
4CG8
2
CHKA_HUMAN
A:
[21-366]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
-
G
------------------
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
WMYDYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
25
Blastp_CBE
71.35
32%
19
- C6 -
-
5EQE
1
CHKA_HUMAN
B:
[39-384]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
-
G
--------------------
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W
-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
Y
DYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
4
PsiBlast_PDB
71.31
31%
15
- C6 -
-
5EQP
1
CHKA_HUMAN
A:
[39-384]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
------------------
G
A
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W
-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
YDYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
16
PsiBlast_PDB
71.28
31%
20
- C6 -
-
2CKO
1
CHKA_HUMAN
A:
[46-373]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
-
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
-
G
A
I
------------------
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
Y
DYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
3
PsiBlast_PDB
71.21
31%
18
- C6 -
-
5EQE
1
CHKA_HUMAN
A:
[39-384]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
-
G
A
I
------------------
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
YDYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
24
Blastp_CBE
71.19
32%
18
- C6 -
-
5EQP
1
CHKA_HUMAN
B:
[39-384]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
-
G
--------------------
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
Y
DYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
7
PsiBlast_PDB
71.01
31%
16
- C6 -
-
5FTG
10
CHKA_HUMAN
A:
[16-361]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
-
G
------------------
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
WMYDYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
21
Blastp_CBE
70.49
32%
17
- C6 -
-
5W6O
4
CHKA_HUMAN
B:
[16-361]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
-
G
------------------
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
YDYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
8
PsiBlast_PDB
70.30
31%
19
- C6 -
-
5FUT
10
CHKA_HUMAN
A:
[16-361]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
-
G
----------------
G
A
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
YDYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
14
PsiBlast_PDB
70.27
31%
17
- C6 -
-
4CGA
1
CHKA_HUMAN
A:
[21-366]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
------------------
G
A
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
YDYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
11
PsiBlast_PDB
69.99
31%
16
- C6 -
-
4BR3
2
CHKA_HUMAN
A:
[21-366]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
------------------
G
A
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
MYDYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
9
PsiBlast_PDB
69.96
31%
17
- C6 -
-
5W6O
6
CHKA_HUMAN
A:
[16-361]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
-
G
------------------
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
YDYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
13
PsiBlast_PDB
69.81
31%
19
- C6 -
-
4CG9
1
CHKA_HUMAN
A:
[21-366]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
------------------
G
A
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
YDYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
29
Blastp_CBE
69.80
32%
20
- C6 -
-
2CKO
1
CHKA_HUMAN
B:
[46-373]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
-
G
------------------
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W
-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
YDYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
15
PsiBlast_PDB
69.63
31%
17
- C6 -
-
4DA5
1
CHKA_HUMAN
A:
[95-440]
----------------------------------------------------------
C
K
E
F
L
-
P
G
-
A
-
W
R
G
L
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
D
T
----
T
ATLG
D
----
E
P
----
R
K
V
L
L
R
L
Y
-------------------
A
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
Y
DYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------
26
Blastp_CBE
65.87
32%
-17
- C6 -
-
3G15
2
CHKA_HUMAN
B:
[39-384]
----------------------------------------------------------
C
K
E
F
L
-
P
--
A
-
W
-------------------
M
L
F
Q
C
---------------------------
V
L
L
R
L
-----------------------
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
-
L
G
P
K
L
Y
G
I
F
P
Q
G
R
L
E
Q
F
I
P
S
R
R
L
D
T
E
E
L
S
L
---------
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
--------------
M
P
F
N
K
--------------
E
-------
P
-
K
W-------------
L
F
G
T
M
E
K
Y
L
-----
K
E
V
L
R
I
K
---
F
T
--
E
----
E
----
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
----------------
L
L
E
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
----
L
LEGRE
N
-
S
E
-----
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
---------
C
E
W
M
YDYSYEK
Y
---------
P
---------
F
F
R
A
---------
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
---
L
S
T
E
E
K
S
I
I
K
--------------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Y
---------------------