@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O06916_LEGPN: (2019-01-31 )
MLKQPIQAQQLIELLKVHYGIDIHTAQFIQGGADTNAFAYQADSESKSYFIKLKYGYHDEINLSIIRLLHDSGIKEIIFPIHTLEAKLFQQLKHFKIIAYPFIHAPNGFTQNLTGKQWKQLGKVLRQIHETSVPISIQQQLRKEIYSPKWREIVRSFYNQIEFDNSDDKLTAAFKSFFNQNSAAIHRLVDTSEKLSKKIQPDLDKYVLCHSDIHAGNVLVGNEESIYIIDWDEPMLAPKERDLMFIGGGVGNVWNKPHEIQYFYEGYGEINVDKTILSYYRHERIVEDIAVYGQDLLSRNQNNQSRLESFKYFKEMFDPNNVVEIAFATEQ
Atome Classification :
(20 SA)
-------.......-------..10........-----20--.--.-......30........40......---------..50......---.-----.-------60.....-...70-....-....80........90.----.......100......-.110..-----------......120-.....-..130.......140.......150.......160..-----..------....170.......180.......190..--...------..-200.......210.......220--.---......230.......240...-....250--.-----------.--.-.-------------------...260.-......270--.----.---.......280..-...-..290.......------300---...---....310.......320..-.....330------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------MLKQP
I
Q
-------
A
Q
Q
L
I
E
L
L
K
V
H
Y-----GI--D--I-
H
T
A
Q
F
IQGGADTN
A
F
A
Y
QADSES
K
---------
S
Y
F
I
K
L
K
YGY---H-----D-------E
I
N
L
S
I
I
-
R
L
L
H
D-SG
I
K
-
E
I
I
F
P
I
H
T
L
E
A
K
L
F
Q
Q
L
----
K
H
F
K
I
I
A
Y
P
F
I
HAPNG-FT-QNL-----------
T
G
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
-
I
H
ETSVP
I
S
I
Q
Q
Q
L
R
K
E
IY
S
P
K
W
R
E
I
V
R
S
F
Y
N
Q-IEF-----DN------SD
D
K
L
T
A
A
F
K
S
F
FNQ
N
S
A
A
I
H
R
LVD
T
S
E
K
--
L
S
K
------KI-QPDLD
K
Y
V
L
CHSDIHAG
N
V
L
VGN--E---
E
S
I
Y
I
I
DWDEPMLAPKER
D
L
M
F
-IGGGVGN--V-----------W--N-K-------------------PH
E
I
Q
Y
F
-
Y
EGYGEI----N----
V
---
D
K
T
I
L
S
Y
Y
R
H
E
R
-
I
V
E
-
D
I
A
V
Y
G
Q
D
L
L
SR------NQN---
N
Q
S
---
R
L
E
S
F
K
Y
F
K
E
MFDPN
N
V
V
E
-
I
A
FATEQ-------------
39
HHSearch
96.52
100%
-120
- C4 -
-
3I1A
4
?
B:
[2-330]
--------
L
K
Q
P
I
Q
-------
A
Q
Q
L
I
E
L
L
K
V
H
Y
-----
G
I
--
D
--
I
-
H
T
A
Q
F
I
Q
G
G
A
D
T
N
A
F
A
Y
Q
A
D
S
E
S
K
---------
S
Y
F
I
K
L
K
Y
G
Y
---
H
-----
D
-------
E
I
N
L
S
I
I
-
R
L
L
H
D
-
S
G
I
K
-
E
I
I
F
P
I
H
T
L
E
A
K
L
F
Q
Q
L
----
K
H
F
K
I
I
A
Y
P
F
I
H
A
P
N
G
-
F
T
-
Q
N
L
-----------
T
G
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
-
I
H
E
T
S
V
P
I
S
I
Q
Q
Q
L
R
K
E
I
Y
S
P
K
W
R
E
I
V
R
S
F
Y
N
Q
-
I
E
F
-----
D
N
------
S
D
D
K
L
T
A
A
F
K
S
F
F
N
Q
N
S
A
A
I
H
R
L
V
D
T
S
E
K
--
L
S
K
------
K
I
-
Q
P
D
L
D
K
Y
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
--
E
---
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
-
I
G
G
G
V
G
N
--
V
-----------
W
--
N
-
K
-------------------
P
H
E
I
Q
Y
F
-
Y
E
G
Y
G
E
I
----
N
----
V
---
D
K
T
I
L
S
Y
Y
R
H
E
R
-
I
V
E
-
D
I
A
V
Y
G
Q
D
L
L
S
R
------
N
Q
N
---
N
Q
S
---
R
L
E
S
F
K
Y
F
K
E
M
F
D
P
N
N
V
V
E
-
I
A
F
A
T
E
--------------
21
Blastp_CBE
96.52
100%
-120
- C4 -
-
3I1A
4
?
B:
[2-330]
--------
L
K
Q
P
I
Q
-------
A
Q
Q
L
I
E
L
L
K
V
H
Y
-----
G
I
--
D
--
I
-
H
T
A
Q
F
I
Q
G
G
A
D
T
N
A
F
A
Y
Q
A
D
S
E
S
K
---------
S
Y
F
I
K
L
K
Y
G
Y
---
H
-----
D
-------
E
I
N
L
S
I
I
-
R
L
L
H
D
-
S
G
I
K
-
E
I
I
F
P
I
H
T
L
E
A
K
L
F
Q
Q
L
----
K
H
F
K
I
I
A
Y
P
F
I
H
A
P
N
G
-
F
T
-
Q
N
L
-----------
T
G
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
-
I
H
E
T
S
V
P
I
S
I
Q
Q
Q
L
R
K
E
I
Y
S
P
K
W
R
E
I
V
R
S
F
Y
N
Q
-
I
E
F
-----
D
N
------
S
D
D
K
L
T
A
A
F
K
S
F
F
N
Q
N
S
A
A
I
H
R
L
V
D
T
S
E
K
--
L
S
K
------
K
I
-
Q
P
D
L
D
K
Y
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
--
E
---
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
-
I
G
G
G
V
G
N
--
V
-----------
W
--
N
-
K
-------------------
P
H
E
I
Q
Y
F
-
Y
E
G
Y
G
E
I
----
N
----
V
---
D
K
T
I
L
S
Y
Y
R
H
E
R
-
I
V
E
-
D
I
A
V
Y
G
Q
D
L
L
S
R
------
N
Q
N
---
N
Q
S
---
R
L
E
S
F
K
Y
F
K
E
M
F
D
P
N
N
V
V
E
-
I
A
F
A
T
E
--------------
1
PsiBlast_PDB
95.79
100%
-120
- C4 -
-
3I0O
2
?
A:
[4-331]
----------
Q
P
I
Q
-------
A
Q
Q
L
I
E
L
L
K
V
H
Y
-----
G
I
--
D
--
I
-
H
T
A
Q
F
I
Q
G
G
A
D
T
N
A
F
A
Y
Q
A
D
S
E
S
K
---------
S
Y
F
I
K
L
K
Y
G
Y
---
H
-----
D
-------
E
I
N
L
S
I
I
-
R
L
L
H
D
-
S
G
I
K
-
E
I
I
F
P
I
H
T
L
E
A
K
L
F
Q
Q
L
----
K
H
F
K
I
I
A
Y
P
F
I
H
A
P
N
G
-
F
T
-
Q
N
L
-----------
T
G
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
-
I
H
E
T
S
V
P
I
S
I
Q
Q
Q
L
R
K
E
I
Y
S
P
K
W
R
E
I
V
R
S
F
Y
N
Q
-
I
E
F
-----
D
N
------
S
D
D
K
L
T
A
A
F
K
S
F
F
N
Q
N
S
A
A
I
H
R
L
V
D
T
S
E
K
--
L
S
K
------
K
I
-
Q
P
D
L
D
K
Y
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
--
E
---
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
-
I
G
G
G
V
G
N
--
V
-----------
W
--
N
-
K
-------------------
P
H
E
I
Q
Y
F
-
Y
E
G
Y
G
E
I
----
N
----
V
---
D
K
T
I
L
S
Y
Y
R
H
E
R
-
I
V
E
-
D
I
A
V
Y
G
Q
D
L
L
S
R
------
N
Q
N
---
N
Q
S
---
R
L
E
S
F
K
Y
F
K
E
M
F
D
P
N
N
V
V
E
-
I
A
F
A
T
E
Q
-------------
24
Fugue
95.70
100%
-118
- C4 -
-
3I1A
2
?
A:
[3-330]
---------
K
Q
P
I
Q
-------
A
Q
Q
L
I
E
L
L
K
V
H
Y
-----
G
I
--
D
--
I
-
H
T
A
Q
F
I
Q
G
G
A
D
T
N
A
F
A
Y
Q
A
D
S
E
S
K
---------
S
Y
F
I
K
L
K
Y
G
Y
---
H
-----
D
-------
E
I
N
L
S
I
I
-
R
L
L
H
D
-
S
G
I
K
-
E
I
I
F
P
I
H
T
L
E
A
K
L
F
Q
Q
L
----
K
H
F
K
I
I
A
Y
P
F
I
H
A
P
N
G
-
F
T
-
Q
N
L
-----------
T
G
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
-
I
H
E
T
S
V
P
I
S
I
Q
Q
Q
L
R
K
E
I
Y
S
P
K
W
R
E
I
V
R
S
F
Y
N
Q
-
I
E
F
-----
D
N
------
S
D
D
K
L
T
A
A
F
K
S
F
F
N
Q
N
S
A
A
I
H
R
L
V
D
T
S
E
K
--
L
S
K
------
K
I
-
Q
P
D
L
D
K
Y
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
--
E
---
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
-
I
G
G
G
V
G
N
--
V
-----------
W
--
N
-
K
-------------------
P
H
E
I
Q
Y
F
-
Y
E
G
Y
G
E
I
----
N
----
V
---
D
K
T
I
L
S
Y
Y
R
H
E
R
-
I
V
E
-
D
I
A
V
Y
G
Q
D
L
L
S
R
------
N
Q
N
---
N
Q
S
---
R
L
E
S
F
K
Y
F
K
E
M
F
D
P
N
N
V
V
E
-
I
A
F
A
T
E
--------------
3
PsiBlast_PDB
95.70
100%
-118
- C4 -
-
3I1A
2
?
A:
[3-330]
---------
K
Q
P
I
Q
-------
A
Q
Q
L
I
E
L
L
K
V
H
Y
-----
G
I
--
D
--
I
-
H
T
A
Q
F
I
Q
G
G
A
D
T
N
A
F
A
Y
Q
A
D
S
E
S
K
---------
S
Y
F
I
K
L
K
Y
G
Y
---
H
-----
D
-------
E
I
N
L
S
I
I
-
R
L
L
H
D
-
S
G
I
K
-
E
I
I
F
P
I
H
T
L
E
A
K
L
F
Q
Q
L
----
K
H
F
K
I
I
A
Y
P
F
I
H
A
P
N
G
-
F
T
-
Q
N
L
-----------
T
G
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
-
I
H
E
T
S
V
P
I
S
I
Q
Q
Q
L
R
K
E
I
Y
S
P
K
W
R
E
I
V
R
S
F
Y
N
Q
-
I
E
F
-----
D
N
------
S
D
D
K
L
T
A
A
F
K
S
F
F
N
Q
N
S
A
A
I
H
R
L
V
D
T
S
E
K
--
L
S
K
------
K
I
-
Q
P
D
L
D
K
Y
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
--
E
---
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
-
I
G
G
G
V
G
N
--
V
-----------
W
--
N
-
K
-------------------
P
H
E
I
Q
Y
F
-
Y
E
G
Y
G
E
I
----
N
----
V
---
D
K
T
I
L
S
Y
Y
R
H
E
R
-
I
V
E
-
D
I
A
V
Y
G
Q
D
L
L
S
R
------
N
Q
N
---
N
Q
S
---
R
L
E
S
F
K
Y
F
K
E
M
F
D
P
N
N
V
V
E
-
I
A
F
A
T
E
--------------
4
PsiBlast_PDB
95.47
100%
-120
- C4 -
-
3Q2M
1
?
A:
[3-331]
---------
K
Q
P
I
Q
-------
A
Q
Q
L
I
E
L
L
K
V
H
Y
-----
G
I
--
D
--
I
-
H
T
A
Q
F
I
Q
G
G
A
D
T
N
A
F
A
Y
Q
A
D
S
E
S
K
---------
S
Y
F
I
K
L
K
Y
G
Y
---
H
-----
D
-------
E
I
N
L
S
I
I
-
R
L
L
H
D
-
S
G
I
K
-
E
I
I
F
P
I
H
T
L
E
A
K
L
F
Q
Q
L
----
K
H
F
K
I
I
A
Y
P
F
I
H
A
P
N
G
-
F
T
-
Q
N
L
-----------
T
G
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
-
I
H
E
T
S
V
P
I
S
I
Q
Q
Q
L
R
K
E
I
Y
S
P
K
W
R
E
I
V
R
S
F
Y
N
Q
-
I
E
F
-----
D
N
------
S
D
D
K
L
T
A
A
F
K
S
F
F
N
Q
N
S
A
A
I
H
R
L
V
D
T
S
E
K
--
L
S
K
------
K
I
-
Q
P
D
L
D
K
Y
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
--
E
---
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
-
I
G
G
G
V
G
N
--
V
-----------
W
--
N
-
K
-------------------
P
H
E
I
Q
Y
F
-
Y
E
G
Y
G
E
I
----
N
----
V
---
D
K
T
I
L
S
Y
Y
R
H
E
R
-
I
V
E
-
D
I
A
V
Y
G
Q
D
L
L
S
R
------
N
Q
N
---
N
Q
S
---
R
L
E
S
F
K
Y
F
K
E
M
F
D
P
N
N
V
V
E
-
I
A
F
A
T
E
Q
-------------
2
PsiBlast_PDB
93.54
100%
-137
- C4 -
-
3I0Q
1
?
A:
[5-331]
-----------
P
I
Q
-------
A
Q
Q
L
I
E
L
L
K
V
H
Y
-----
G
I
--
D
--
I
-
H
T
A
Q
F
I
Q
------
A
F
A
Y
Q
A
D
S
E
S
K
---------
S
Y
F
I
K
L
K
Y
G
Y
---
H
-----
D
-------
E
I
N
L
S
I
I
-
R
L
L
H
D
-
S
G
I
K
-
E
I
I
F
P
I
H
T
L
E
A
K
L
F
Q
Q
L
----
K
H
F
K
I
I
A
Y
P
F
I
H
A
P
N
G
-
F
T
-
Q
N
L
-----------
T
G
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
-
I
H
E
T
S
V
P
I
S
I
Q
Q
Q
L
R
K
E
I
Y
S
P
K
W
R
E
I
V
R
S
F
Y
N
Q
-
I
E
F
-----
D
N
------
S
D
D
K
L
T
A
A
F
K
S
F
F
N
Q
N
S
A
A
I
H
R
L
V
D
T
S
E
K
--
L
S
K
------
K
I
-
Q
P
D
L
D
K
Y
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
--
E
---
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
-
I
G
G
G
V
G
N
--
V
-----------
W
--
N
-
K
-------------------
P
H
E
I
Q
Y
F
-
Y
E
G
Y
G
E
I
----
N
----
V
---
D
K
T
I
L
S
Y
Y
R
H
E
R
-
I
V
E
-
D
I
A
V
Y
G
Q
D
L
L
--------------
N
Q
S
---
R
L
E
S
F
K
Y
F
K
E
M
F
D
P
N
N
V
V
E
-
I
A
F
A
T
E
Q
-------------
27
Fugue
41.42
13%
-23
- C4 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
----------
T
D
I
T
-------
E
D
E
L
R
N
F
L
T
--------
Q
Y
--
D
--
V
-
G
S
L
T
S
Y
K
G
I
A
E
N
S
N
F
L
L
H
T
T
K
--
D
---------
P
L
I
L
T
L
Y
E
K
K
---
N
-----
D
-------
L
P
F
F
L
G
L
M
Q
H
L
A
A
-
K
G
L
S
--
C
P
L
P
L
P
R
K
D
G
E
L
L
G
E
L
----
S
G
R
P
A
A
L
I
S
F
L
---
E
G
M
W
L
-
R
K
P
-----------
E
A
K
H
C
R
E
V
G
-
K
A
L
A
A
M
H
L
A
S
E
---
G
F
E
I
K
R
P
N
A
L
S
V
D
G
W
K
V
L
W
D
K
S
E
E
R
-
A
D
E
-----
V
E
------
K
G
----------------
L
R
E
E
I
R
P
E
I
D
Y
--
L
A
A
------
H
W
-
P
K
D
L
P
A
G
V
I
-
H
A
D
L
F
Q
D
N
V
F
F
L
G
--
D
---
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
-
C
L
N
A
W
C
F
--
E
-----------
K
--
D
-
G
AYN----------------
V
T
K
G
K
A
L
-
L
E
G
Y
Q
S
V
R
P
L
S
E
----
A
---
E
L
E
A
L
P
L
L
S
R
G
S
-
A
L
R
-
F
F
L
T
R
L
Y
D
W
L
T
T
------
P
A
G
---
A
L
V
---
V
K
K
D
P
L
E
Y
L
R
K
L
R
F
H
R
T
I
A
-
N
V
A
E
Y
G
L
A------------
29
Fugue
41.24
13%
-15
- C4 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
-----SA
F
T
F
Q
T
L
H
-------
P
D
T
I
M
D
A
L
F
E
-
H
-----
G
I
--
R
--
V
-
D
S
G
L
T
P
L
N
S
Y
E
N
R
V
Y
Q
F
Q
D
E
D
R
R
R
---------
F
V
V
K
F
Y
R
P
E
R
---
W
-----
T
-------
A
D
Q
I
L
E
E
-
H
Q
F
A
L
-
Q
-
L
V
-
N
D
E
V
P
V
A
A
P
V
A
F
N
G
Q
T
L
----
L
N
H
Q
G
F
Y
F
A
V
F
P
S
V
G
G
-
R
Q
F
E
A
D
-----------
N
I
D
Q
M
E
A
V
G
-
R
Y
L
G
R
-
M
H
Q
T
G
R
K
Q
L
F
I
H
---------------
R
P
T
I
G
L
-
N
E
Y
-----
L
I
------
E
P
R
K
L
F
E
D
A
T
L
I
P
S
G
L
K
A
A
F
L
K
A
T
D
E
L
I
A
--
A
V
T
------
A
H
-
W
R
E
D
F
T
V
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
--
G
-----
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
-
L
L
N
G
--
D
--
K
-----------
A
--
E
-
Q
-------------------
R
M
Q
L
E
T
I
-
I
E
A
Y
E
E
F
S---
E
----
F
---
D
T
A
E
I
G
L
I
E
P
L
R
-
A
M
R
-
L
V
Y
Y
L
A
--
W
L
M
R
------
R
W
A
---
D
P
A
---
F
P
K
N
F
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
-
T
F
I
E
Q
A
K
V
L
Q
EPPLQLTPMY
41
HHSearch
38.14
14%
28
- C4 -
-
6EF6
2
?
A:
[27-348]
---------------------
D
V
T
I
A
Q
Q
A
L
T
H
Y
-----
D
V
--
S
--
D
N
A
S
L
R
L
L
-
N
L
S
E
N
--
A
T
Y
L
V
E
D
G
E
H
---------
Q
S
I
L
R
V
H
R
Q
D
---
Y
HQ
P
H
E
I
-------
E
S
E
L
D
W
L
-
A
A
L
R
T
D
S
D
V
T
--
V
P
T
V
V
P
A
R
D
G
R
R
V
V
T
V
D
P
A
D
V
P
R
H
V
V
H
F
E
M
V
G
G
A
E
P
-
D
E
-
E
S
L
-----------
T
L
D
D
F
Q
T
L
G
-
R
I
T
A
S
-
L
H
E
H
S
Q
R
W
T
R
P
A
G
F
G
R
F
S
W
D
--
W
E
H
C
L
G
D
T
-
P
R
-
W
G
R
-----
W
--------
Q
D
A
E
--
G
V
G
A
---
S
E
T
A
L
L
T
R
A
Q
D
L
L
H
R
--
K
L
E
------
E
Y
-
G
S
G
P
D
R
Y
G
L
I
H
A
D
L
R
L
A
N
L
L
V
D
S
--
S
TPQ
R
T
I
T
V
I
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
G
T
-
A
V
S
F
I
E
H
--
D
-----------
P
--
R
-
L
-------------------
G
E
W
Q
E
S
W
-
V
A
G
Y
R
S
R
----
R
E
L
P
A
A
---
D
E
A
M
L
P
S
F
V
F
L
R
-
R
L
L
-
L
L
A
W
M
G
S
H
T
H
S
R
------
E
S
A
T
K
A
I
S
Y
---
A
A
G
S
C
A
L
A
E
R
Y
L
S
S
--------------------------
42
HHSearch
37.10
16%
-21
- C4 -
-
2Q83
4
COTI_BACSU
A:
[19-289]
---------------------
L
T
E
L
A
E
N
V
L
Q
G
W
-----
D
V
--
Q
--
A
-
E
K
I
D
V
I
Q
----
A
--
L
V
W
K
V
H
T
D
S
G
---------
A
V
C
L
K
R
I
H
R
P
---
E
K
K
---
A
-------
L
F
S
I
F
A
Q
-
D
Y
L
A
K
-
K
G
M
N
--
V
P
G
I
L
P
N
K
K
G
S
L
Y
S
K
H
----
G
S
F
L
F
V
V
Y
D
W
I
E
G
R
P
F
-
E
L
---
T
-----------
V
K
Q
D
L
E
F
I
M
-
K
G
L
A
D
-
F
H
T
A
S
V
G
Y
Q
P
P
N
G
V
P
I
F
T
K
L
G
R
W
P
N
H
Y
T
K
R
C
K
Q
-
M
E
T
-----
W
K
L
M
A
E
A
E
K
E
D
P
F
S
Q
L
Y
L
Q
E
I
D
G
F
I
E
D
G
L
R
I
K
D
R
L
L
Q
S-
T
Y
V
------
P
W
T
E
Q
L
K
K
S
P
N
L
C
H
Q
D
Y
G
T
G
N
T
L
L
G
E
--
N
---
E
Q
I
W
V
I
D
L
D
T
V
S
F
D
L
P
I
R
D
L
R
K
-
M
I
I
P
L
L
D
--
T
TGV--------
W
--
D
---------------------
D
E
T
F
N
V
M
-
L
N
A
Y
E
S
R
----
A
-----------------------------------------------------------------------------------------------
44
HHSearch
36.69
14%
-27
* C4 *
-
2PPQ
-
KHSE_AGRFC
A:
[8-281]
-------------
T
-------
E
D
E
L
R
N
F
L
-
T
Q
Y
-----
D
V
--
G
S-
L
-
T
S
Y
K
G
I
A
E
---
N
--
S
N
F
L
L
H
T
T
K
D
---------
P
L
I
L
T
L
Y
E
K
-----KN
D
--
L
-------
P
F
F
L
G
L
M
-
Q
H
L
A
A
-
K
G
L
S
--
C
P
L
P
L
P
R
K
D
G
E
L
L
G
E
L
----
S
G
R
P
A
A
L
I
S
F
L
E
G
M
W
L
-
R
K
---
P
-----------
E
A
K
H
C
R
E
V
G
-
K
A
L
A
A
-
M
H
L
A
S
E
G
F
E
I
K
R
P
N
--
A
L
S
V
D
G
W
K
V
L
W
D
K
S
E
E
R
-
A
D
E
---------------------
V
E
K
G
L
---
R
E
E
I
R
P
E
I
D
Y
------
L
A
------
A
H
-
W
P
K
D
L
P
A
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
--
D
---
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
-
C
L
N
A
W
C
F
--
E
-----------
K
DG
A
Y
N
-------------------
V
T
K
G
K
A
L
-
L
E
G
Y
Q
S
V
----
R
P
L
S
E
A
---
E
L
E
A
L
P
L
L
S
R
G
S
-
A
L
R
-
F
F
L
T
R
L
----------------------------------------------------------------
46
HHSearch
36.50
16%
-32
- C4 -
-
1ZYL
-
SRKA_ECOLI
A:
[10-280]
-----------
T
L
H
-------
P
D
T
I
M
D
A
L
-
F
E
H
-----
G
I
--
R
--
V
D
S
G
L
T
P
L
-
N
S
Y
E
N
--
R
V
Y
Q
F
Q
D
E
D
R
R
--------
R
F
V
V
K
F
Y
R
P
E
---
R
WT
A
D
Q
I
-------
L
E
E
H
Q
F
A
-
L
Q
L
V
N
-
D
E
V
P
--
V
A
A
P
V
A
-
F
N
G
Q
T
L
L
N
H
----
Q
G
F
Y
F
A
V
F
P
S
V
G
G
R
Q
F
-
E
A
-
D
-------------
N
I
D
Q
M
E
A
V
G
-
R
Y
L
G
R
-
M
H
Q
T
G
R
K
Q
L
F
I
H
R
P
-
T
I
G
-
L
N
E
Y
L
I
E
P
R
K
L
----
F
E
D
-----
A
T
---------
L
I
P
S
G
L
K
A
A
F
L
-------
K
A
T
D
E
L
I
A
--
A
V
T
------
A
H
-
W
R
E
D
F
T
V
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
-------
G
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
-
L
L
N
G
D
K
A
--
E
--------------
Q
---------------------
R
M
Q
L
E
T
I
-
I
E
A
Y
E
E
F
----
S
E---
F
DTA
E
I
G
L
I
E
P
L
R
A
M
R
-
L
V
Y
-
Y
L
A
W
------------------------------------------------------------------
40
HHSearch
35.70
13%
-37
- C4 -
-
4PDY
1
?
A:
[21-285]
----------------------
P
L
I
P
Q
A
V
V
S
K
Y
-----
D
L
--
A
--
I
-
Q
Q
R
---
H
A
D
G
--
N
--
I
E
V
W
T
D
S
K
G
R
--------
R
Y
A
A
K
R
S
S
I
A
---
P
A
H
---
C
-------
R
I
M
V
Q
C
L
-
R
H
A
Q
E
-
Q
G
F
T
-
K
F
A
R
F
V
T
T
S
S
N
A
P
Y
V
R
H
----
G
D
F
T
Y
Y
V
T
E
W
V
S
G
Q
P
A
-
N
F
-
G
-------------
L
P
E
H
V
A
Q
T
A
-
Y
T
L
A
Q
-
F
H
E
A
T
R
S
F
R
T
D
W
K
---
D
D
V
F
G
L
F
Q
A
R
W
R
D
L
R
Q
M
-
W
L
G
-----
A
D
-------
R
K
R
E
K
D
A
F
D
Q
L
L
L
S
M
R
D
E
L
H
R
D
A
A
E
S
L
A
--
L
F
E
D
R
D
V
I
A
Y
L
-
E
A
E
R
S
S
G
G
W
C
H
L
D
V
I
P
S
N
C
L
Y
T
P
--
Q
---
H
Q
V
V
L
I
D
F
E
L
A
R
P
A
P
R
A
L
D
M
A
H
-
L
L
R
R
S
L
E
R
G
N
-----------
W
--
D
---------------------
G
H
L
A
Y
A
C
-
F
L
H
F
D
A
V
----
R
-----------------------------------------------------------------------------------------------
25
Fugue
34.63
16%
21
- C4 -
-
2Q83
5
COTI_BACSU
A:
[11-346]
------L
S
A
E
D
A
K
K
-------
L
T
E
L
A
E
N
V
L
Q
G
W
-----
D
V
--
Q
--
A
-
E
K
I
D
V
I
Q
A
------
L
V
W
K
V
H
T
D
S
G
---------
A
V
C
L
K
R
I
H
R
P
---
E
-----
K
-------
K
A
L
F
S
I
F
-
A
Q
D
Y
L
-
A
K
K
G
M
N
V
P
G
I
L
P
N
K
K
G
S
L
Y
S
K
H
----
G
S
F
L
F
V
V
Y
D
W
I
---
E
G
-
R
P
-
F
E
L
-----------
T
V
K
Q
D
L
E
F
I
M
K
G
L
A
D
-
F
H
T
A
S
V
G
Y
Q
P
P
N
G
V
P
I
F
T
K
L
G
R
W
P
N
H
Y
T
K
R
C
K
Q
M
E
T
W
K
L
M
A
E
A
E
------
K
E
D
P
F
S
Q
L
Y
L
Q
E
I
D
G
F
I
E
D
G
L
R
I
K
D
R
L
L
Q
ST
Y
V
P
------
W
T
-
E
Q
L
K
K
S
P
N
L
C
H
Q
D
Y
G
T
G
N
T
L
L
G
E
--
N
---
E
Q
I
W
V
I
D
L
D
T
V
S
F
D
L
P
I
R
D
L
R
K
M
I
I
P
L
L
D
T
--
T
-----------
G
--
V
-
W
-------------------
D
D
E
T
F
N
V
M
L
N
A
Y
E
S
R
----
A
----
P
-------
L
T
E
E
Q
K
Q
V
M
F
I
D
M
L
F
P
Y
E
L
Y
D
V
I
R
E
------
K
Y
V
---
R
K
S
---
A
L
-
P
K
E
E
L
E
S
A
F
E
Y
E
R
I
K
A
-
N
A
L
R
Q
L
I
-------------
56
HHSearch
34.02
17%
0
- C4 -
-
5UXD
2
?
A:
[6-252]
-------------
D
-------
L
D
A
L
L
D
L
A
-
A
R
H
-----
G
L
--
D
LD
G
-
G
T
L
R
T
E
E
I
G
L
D
F
--
R
V
A
F
A
R
A
H
D
G
G
--------
D
W
V
L
R
L
P
R
R
P
---
D
V
L
E
R
-
A
-------
A
V
E
G
R
L
L
-
A
M
L
A
P
H
L
D
V
A
--
V
P
D
W
R
I
S
--------------
T
S
E
L
I
A
Y
P
L
L
P
G
S
P
G
-
L
T
-
V
A
A
DG
E
V
S
W
HVDMA
S
T
V
Y
A
R
S
L
G
-
S
V
V
A
Q
-
L
H
A
V
D
A
E
A
A
A
A
T
G
I
E
V
R
S
-
P
A
Q
V
R
G
A
---
W
R
Q
D
-
L
A
R
-----
V
--------
G
A
----
E
F
-----
E
I
A
P
A
L
---
R
E
R
W
E
A
--
W
L
A
------
D
D
-
G
C
W
P
G
H
S
V
L
T
H
G
E
L
Y
P
A
H
T
L
V
E
D
--
E
---
R
I
T
A
V
L
D
W
T
T
A
A
V
G
D
P
A
K
D
L
M
F
-
H
Q
V
S
A
-
P
---------------------------------------
S
A
I
F
E
V
A
-
L
Q
A
Y
A
E
G
----
G
-----------------------------------------------------------------------------------------------
45
HHSearch
32.42
11%
-6
- C4 -
-
4WH3
8
NAHK_BIFL2
A:
[5-279]
----------------------
N
E
V
L
F
G
I
A
S
H
F
-----
A
L
EG
A
--
V
-
T
G
I
E
P
Y
G
D
G
H
I
N
--
T
T
Y
L
V
T
T
D
G
P
---------
R
Y
I
L
Q
Q
M
N
T
S
---
I
-----
F
PD
T
V
N
L
M
R
N
V
E
L
V
T
-
S
T
L
K
A
-
Q
G
K
E
--
T
L
D
I
V
P
T
T
S
G
A
T
W
A
E
I
----
D
G
G
A
W
R
V
Y
K
F
I
E
H
T
V
S
-
Y
N
-
L
V
P
-----------
N
P
D
V
F
R
E
A
G
-
S
A
F
G
D
-
F
Q
N
F
L
S
E
F
D
A
S
Q
L
T
E
T
I
A
H
F
H
D
T
P
H
R
F
E
D
F
K
A
A
-
L
A
A
-----
D
----------
K
L
-
G
R
A
A
A
-
C
Q
P
E
I
D
F
Y
L
S
H
A
D
Q
Y
A
V
--
V
M
D
------
G
L
-
R
D
G
S
I
P
L
R
V
T
H
N
D
T
K
L
N
N
I
L
M
D
A
TT
G
---
K
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
-
S
I
R
F
G
A
S
--
T
ALEDEKDLSK
V
H
--
F
-
S
-------------------
T
E
L
F
R
A
Y
-
T
E
G
F
V
G
E
----------------------------------------------------------------------------------------------------
43
HHSearch
32.31
11%
8
- C4 -
-
4OCV
2
?
A:
[24-298]
---------------------
T
N
E
A
L
F
D
V
A
S
H
F
-----
A
L
EG
T
--
V
-
D
S
I
E
P
Y
G
D
G
H
I
N
--
T
T
Y
L
V
T
T
D
G
P
---------
R
Y
I
L
Q
R
M
N
T
G
---
I
-----
F
PD
T
V
N
L
M
R
N
V
E
L
V
T
-
S
T
L
K
A
-
Q
G
K
E
--
T
L
D
I
V
R
T
T
S
G
D
T
W
A
E
I
----
D
G
G
A
W
R
V
Y
K
F
I
E
H
T
M
S
-
Y
N
-
L
V
P
-----------
N
P
D
V
F
R
E
A
G
-
R
A
F
G
D
-
F
Q
N
F
L
S
G
F
D
A
N
Q
L
T
E
T
I
A
H
F
H
D
T
P
H
R
F
E
D
F
K
K
A
-
L
A
A
-----
D
----------
E
L
-
G
R
A
A
G
-
C
G
P
E
I
E
F
Y
L
S
H
A
D
Q
Y
A
V
--
V
M
D
------
G
L
-
R
D
G
S
I
P
L
R
V
T
H
N
D
T
K
L
N
N
I
L
M
D
A
TT
G
---
K
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
-
S
I
R
F
G
A
S
--
T
ALEDERDL---
D
K
V
H
F
S
-------------------
T
E
L
F
R
A
Y
-
T
E
G
F
V
G
-----------------------------------------------------------------------------------------------------
64
SP3
32.22
9%
10
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
M
D
L
D
T
D
ANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
GGAWK
T
V
--
P
--
L
-
E
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
S
E
V
YPPIRNEPN
K
V
L
L
R
V
Y
F
N
P
---
E
-----
T
-------
E
S
H
L
V
A
E
-
S
V
I
F
T
-
L
L
S
E
-
R
------
H
L
G
P
K
L
Y
G
I
F
----
S
G
--
G
R
L
E
E
Y
I
P
S
R
P
L
-
S
C
-
H
E
I
S
----------
L
A
H
M
S
T
K
I
A
-
K
R
V
A
K
-
V
H
Q
L
E
V
P
I
W
--------
K
E
P
D
Y
L
C
E
A
L
Q
R
W
L
K
Q
-
L
T
G
-----
T
V
------
D
A
E
H
R
F
D
L
P
E
E
C
-
G
V
S
S
V
N
C
L
D
L
A
R
E
L
E
F
--
L
R
A
------
H
I
-
S
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
--
R
---
L
V
--
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
-
H
F
I
E
W
T
I
--
D
-----------
Y
--
D
-
I
DEAPF
Y
K
I
Q
TENFPE
N
D
Q
M
L
E
F
F
L
N
Y
-
L
R
E
Q
G
N
T
----
R
----
E
---
N
E
L
Y
K
K
S
E
D
L
V
Q
-
E
T
L
-
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
---
P
V
G
FG
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A
------------------
50
HHSearch
31.98
14%
14
- C4 -
-
1ND4
1
KKA2_KLEPN
A:
[10-261]
----------------------
G
S
P
A
A
W
V
E
R
L
F
-----
G
Y
--
D
-----
W
A
Q
Q
T
I
G
C
S
D
A
--
A
V
F
R
L
S
A
Q
G
R
P
--------
V
L
F
V
K
T
D
L
S
G
ALN
E
-----
L
-------
Q
D
E
A
A
R
L
-
S
W
L
A
T
-
T
G
V
P
--
C
A
A
V
L
D
V
V
T
E
----------
A
G
R
D
W
L
L
L
G
E
V
P
G
Q
D
L
-
L
S
-
S
H
L
A----------
P
A
E
K
V
S
I
M
A
-
D
A
M
R
R
-
L
H
T
L
D
P
A
T
C
P
F
D
H
Q
A
-
K
H
R
I
E
R
A
R
T
R
M
E
A
G
L
V
----
D
--------------
Q
----
D
D
L
D
E
E
H
Q
--
G
L
A
P
A
E
L
F
A
R
L
K
-----
A
------
R
M
--
P
D
G
E
D
L
V
V
T
H
G
D
A
C
L
P
N
I
M
V
E
N
--
G
---
R
F
S
G
F
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
-
A
T
R
D
I
A
E
--
E
-----------
L
--
G
---------------------
G
E
W
A
D
R
F
-
L
V
L
Y
G
I
A
----
A
----
P
---
D
S
Q
R
I
A
F
Y
R
L
L
D
---------------------------------------------------------------------------