@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O61882_CAEEL: (2019-02-01 )
MSTKPLSILQPGTGLFNTHVTLEDVNKAIKEQMSTESELTAESKMEVIGEGNGFSSCVILITCHWTIPSSHLPKKLILKIVSFVHVQGLLNKSNEEGNSVMSPEEEAHVHAHFEKSCQKGHNLEVEFCEAFGHLEGLLLPKVFFSQKFEEDNPNKGFVGMEFVEGSVVRHCYENVTVDELQPILKALARLQALSLSTESCRNLDNGEAFEESLMDMLSEDGLKGIFDQSRNIDQKLSEKVERIEQNHKEILNLETVLNLNKVVGIDQKVICHGDLWAANILWTQTDGGFIADKVLDYQESHMGNPAEDLVRLLVSTISGADRQSHWEHILEQFYTYFTDEIGSNNAPYTLEQLKTSFKLYFPVGALTLISLFGPAVDMKLQGMESGKAENYRRIVIEKVDCLLDDVLNFHDFNKKFTGKN
Atome Classification :
(20 SA)
-----------------.........10........20.-----.......30-----........40-......--...50........60...-....----------..-70........80...------.....90........100.......110.......120.......130.......140.......150-------.......-.160.....-..170-.---------.---------.---..----..--180.......190.--......200...--.-...210........220...-..-.-..230--..-....---.240.......250...--------....----260-....---...270.......280...--....290.......300.......310..--------...---------------..---------------320--------------.-------------.-----------.....-------.330.......340.---......350.........360.----------...--...370.......-380.......390.......400.....--.-------.410.......420--
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------MSTKP
L
S
I
LQPGTGLFN
T
H
V
T
L
-----
E
D
V
N
K
A
I
K
E
-----
Q
MST
E
S
ELT--AE
S
K
M
E
--
V
I
GEGNGF
S
S
C
V
I
L
-
I
T
C
-
H
W
TI----------
P
S
-SHL
P
K
K
L
I
L
K
I
V
S
F
V
------
H
V
Q
G
L
L
NKSNEEGNSVMSP
E
E
E
A
H
V
H
A
H
F
E
K
S
C
QKGHN
L
E
V
E
F
C
E
A
F
G
H
L
E
G
L
L
L
P
K
V
F
F
S
Q
KFEE-D-------NPNKG
F
V
-
G
M
E
F
V
E
G
S
V
-
V
R
H
C
Y
-E---------N---------V---
T
V
----
D
E
--
L
Q
P
I
L
K
A
L
A
R
L
Q
A
L--SL
S
T
E
S
CRNLDN--
G
-
E
A
F
E
-
E
S
L
M
D
M
L
S
EDG-
L
K
G
-
I
F
-D-QSR
N
I
--
D
Q
-
K
L
S
E
---
K
V
E
R
I
E
Q
N
H
K
E
I
L
N
L
E
T
--------
V
LN
L
----
N
K
V-VGID---
Q
K
V
I
CHGD
L
W
A
A
N
I
L
W
TQT--DG
G
F
I
A
D
K
V
L
D
Y
Q
E
S
HMGN
P
A
E
D
L
V
R
L
L
V
--------
S
TI---------------SG---------------AD---------------
R
-------------
Q
-----------
S
H
W
E
H
-------
I
L
E
Q
F
Y
T
Y
F
T
D
EIGS---NNA
P
Y
T
L
--
E
Q
L
KTS
F
K
L
Y
FP
V
----------
G
A
L
--
T
L
I
S
L
FGPAV
D
M
K
-
L
QGMESGKAE
N
Y
R
R
I
V
I
E
K
V
D
C
L
L
D
D
V
L
--
N
-------
F
H
DFNKKFTGKN----
64
Fugue
81.67
13%
-72
- C4 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
------------------------------------
T
L
P
-----
A
V
I
S
R
W
L
S
S
-----
V
L
P
G
G
A
A
----
P
E
V
T
V
E
--
S
G
V
D
S
T
G
M
S
S
E
T
I
I
-
L
T
A
-
R
W
Q
Q
----------
D
G
-
R
S
I
Q
Q
K
L
V
A
R
V
-----------------
A
P
A
A
E
D
V
P
V
F
P
T
Y
R
---------------
L
D
H
Q
F
E
V
I
R
L
V
G
E
L
T
D
V
P
V
P
R
V
R
W
I
E
T
-
T
G
-
D
-------
V
L
G
T
P
F
F
-
L
M
D
Y
V
E
G
V
V
-
P
P
D
V
M
-
P
---------
Y
---------
T
---
F
G
----
D
N
--
W
F
A
D
A
P
A
E
R
Q
R
Q
L
Q
--
D
A
T
V
A
A
L
A
T
L
H
S
--
I
-
P
N
A
Q
-
N
T
F
S
F
L
-
T
D
T
T
-
L
H
R
-
H
F
-
N
-
W
V
R
S
W
--
Y
D
-
F
A
V
E
---
G
I
G
R
S
P
L
L
E
R
T
F
E
W
L
Q
S
----------
H
W
----
P
D
D
-
A
A
A
R
---
E
P
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
F
------
Q
P
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
W
M
I
F
--------
A
H
R
---------------
V
F
---------------
Q
E
---------------
L
-------------
A
-----------
G
L
A
T
L
PGLPEVM
R
E
D
D
V
R
A
T
Y
Q
A
L
T
G
V
---
E
L
G
-----------
D
L
H
W
F
Y
V
Y
----------
S
G
V
--
M
W
A
C
V
F
M
R
T
G
A
R
R
-
V
H
F
G
E
I
E
K
P
D
D
V
E
S
L
------
F
Y
H
A
G
L
M
--
K
-------
H
L
L
G
E
E
H
---------
34
HHSearch
70.69
15%
-2
- C4 -
-
5FTG
11
CHKA_HUMAN
A:
[7-340]
------------------------------------
R
T
R
-----
R
R
A
Y
L
W
C
K
E
-----
F
L
P
G
A
W
R
G
L
RE
D
E
F
H
I
S
--
V
I
R
G
--
G
L
S
N
M
L
F
Q
-
C
S
L
-
P
D
T
T
----------
A
T
L
G
D
E
P
R
K
V
L
L
R
L
Y
G
-------------------------------------
E
-----
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
-
S
L
G
-
P
K
L
Y
G
I
F
P
----------------
Q
G
R
-
L
E
Q
F
I
P
S
R
R
-
L
D
T
E
E
-----------
L
---------
S
---
L
P
----
D
I
--
S
A
E
I
A
E
K
M
A
T
F
H
G
M
--
K
M
P
F
N
K
E
P
K
W
L
--------
F
-
G
T
M
E
K
Y
L
K
--
E
-
V
L
R
-
I
K
F
T
-
E
E
S
R
I
---
K
-
K
L
H
K
---
L
L
S
Y
---
N
L
P
L
E
L
E
-
N
L
--------
R
S
L
L
----
E
S
--
T
P
-
S
---
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
E
G
RE
N
S
E
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
--------
E
W
M
---------------
Y
D
YSYEKYPF
F
R
A
N
IRK
Y
P
---------------
T
-------------
K
-----------
K
Q
Q
L
H
-------
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
LS
T
E
E
K
S
I
I
K
--
E
E
M
L
L
E
V
N
R
F
A
L
A
----------
S
H
F
--
L
-------------------------------------------------------------------
33
HHSearch
67.78
15%
-6
* C4 *
-
5FUT
10
CHKA_HUMAN
A:
[7-340]
------------------------------------
R
T
R
-----
R
R
A
Y
L
W
C
K
E
-----
F
L
P
G
A
W
R
G
L
RE
D
E
F
H
I
S
--
V
I
R
G
--
G
L
S
N
M
L
F
Q
-
C
S
L
-
P
D
T
T
----------
A
T
L
G
D
E
P
R
K
V
L
L
R
L
Y
G
-----------------------------------
G
A
E
-----
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
-
S
L
G
-
P
K
L
Y
G
I
F
P
----------------
Q
G
R
-
L
E
Q
F
I
P
S
R
R
-
L
D
T
E
E
-----------
L
---------
S
---
L
P
----
D
I
--
S
A
E
I
A
E
K
M
A
T
F
H
G
M
--
K
M
P
F
N
K
E
P
K
W
L
--------
F
-
G
T
M
E
K
Y
L
K
--
E
-
V
L
R
-
I
K
F
T
-
E
E
S
R
I
---
K
-
K
L
H
K
---
L
L
S
Y
---
N
L
P
L
E
L
E
-
N
L
--------
R
S
L
L
----
E
S
--
T
P
-
S
---
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
E
G
RE
N
S
E
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
--------
E
W
M
---------------
Y
D
YSYEKYPF
F
R
A
N
IRK
Y
P
---------------
T
-------------
K
-----------
K
Q
Q
L
H
-------
F
I
S
S
Y
L
P
A
F
Q
N
D
F
E
N
LS
T
E
E
K
S
I
I
K
--
E
E
M
L
L
E
V
N
R
F
A
L
A
----------
S
H
F
--
L
-------------------------------------------------------------------
28
HHSearch
66.83
13%
-41
- C4 -
-
3CSV
11
?
A:
[4-306]
------------------------------------
S
R
E
-----
D
E
I
R
D
F
L
A
T
-----
H
-
G
Y
--
A
D
-----
W
N
R
T
--
P
----------
R
Y
Q
R
L
R
S
-
P
T
------------------
G
A
K
A
V
L
M
D
W
S
P
E
------
E
G
G
--------------------------------
D
T
Q
P
F
V
D
L
A
Q
Y
L
R
N
L
-
D
I
S
A
P
E
I
Y
A
E
E
H
--------------
A
R
G
L
L
-
L
I
E
D
L
G
D
A
L
-
F
T
E
V
I
-
N
---------
N
---------
D
PAQ
E
M
----
P
L
--
Y
R
A
A
V
D
L
L
I
H
L
H
D
A
--
Q
T
P
E
L
A
R
---
L
D
--
P
-
E
T
L
S
-
E
M
T
R
L
-----
A
-
F
S
E
-
Y
R
-
Y
-
A
I
L
G
----
D
-
A
A
E
D
---
N
R
K
R
F
E
H
R
F
A
Q
----------------
I
L
----
S
A
Q
-
L
E
-
G
---
D
M
V
F
V
H
R
D
F
H
A
Q
N
L
L
W
L
P
E
--
R
E
G
L
A
R
V
G
V
I
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
V
S
L
L
Q
--------
D
A
R
---------------
R
----------------
D
V
---------------
P
-------------
A
-----------
Q
V
E
A
Q
-------
M
I
D
H
Y
I
Q
A
T
------------
G
V
D
E
--
S
H
F
R
S
A
Y
A
V
I
A
V
Q
----------
R
N
M
--
R
I
L
---
G
I
F
A
R
L
S
-
Q
R
----
F
G
K
R
H
Y
-
I
E
F
V
P
R
V
W
A
H
F
E
R
G
L
--
A
-------
H
---------------
59
Fugue
66.64
13%
-9
- C4 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
-----------------------------
K
T
P
L
Y
E
T
L
N
E
-----
S
S
A
V
A
L
A
V
K
-----
L
-----------
G
L
T
L
T
--
C
Q
E
I
G
D
G
N
L
N
Y
V
F
H
-
I
Y
----------------------
D
R
A
L
I
I
K
Q
A
V
--------------------
P
Y
W
P
L
T
I
D
---------------
R
A
R
I
E
S
S
A
L
I
R
Q
G
E
H
V
P
H
L
V
P
R
V
F
Y
S
D
--------------
T
E
M
A
V
T
-
V
M
E
D
L
S
H
L
K
I
A
R
K
G
L
-
I
---------
E
---------
G
---
E
N
----
Y
P
H
L
S
Q
H
I
G
E
F
L
G
K
T
L
F
Y
S
S
D
Y
A
L
E
P
K
V
K
K
Q
L
--
V
-
K
Q
F
T
-
N
P
E
L
C
D
I
T
E
R
L
-
V
F
T
-
D
P
-
F
-
F
D
H
D
T
--
N
D
-
F
E
E
E
---
L
R
P
F
V
E
K
L
W
N
N
D
S
V
K
I
E
--------
A
A
K
L
----
K
K
S
-
F
L
T
S
---
A
E
T
L
I
H
G
D
L
H
T
G
S
I
F
A
S
E
H
--
E
-----
T
K
V
I
D
P
E
F
A
F
Y
G
P
I
G
F
D
V
G
Q
F
I
A
--------
N
L
F
---------------
L
N
---------------
A
L
---------------
S
R
DGADR
E
P
L
Y
E
H
V
N
-----------
Q
V
W
E
T
-------
F
E
E
T
F
S
E
A
W
Q
K
D
S
L
D
---
V
Y
A
N
I
D
G
--
Y
L
T
D
T
L
S
H
I
F
E
E
A
----------
I
G
F
--
A
G
C
E
L
I
R
R
T
I
G
L
A
H
V
A
D
L
D
T
I
V
P
F
D
K
R
I
G
R
K
R
L
A
L
E
T
G
T
A
F
I
--
E
KRSEFKT
I
T
D
V
I
E
L
F
K
L
L
V
K---
39
HHSearch
66.44
15%
-39
- C4 -
-
3ATS
1
Y3168_MYCTU
A:
[4-297]
-----------------------------------
A
V
I
S
-----
R
W
L
S
S
V
L
P
G
-----
G
A
-----
A
P
--
E
-
V
T
V
E
SG
V
D
S
T
--
G
M
S
S
E
T
I
I
-
L
T
A
-
R
W
Q
Q
----------
D
G
-
R
S
I
Q
Q
K
L
V
A
R
V
A
P
A
A
------
E
D
V
P
V
---------------------
F
P
T
Y
-----
R
L
D
H
Q
F
E
V
I
R
L
V
G
E
L
T
D
V
P
V
P
R
V
R
W
I
E
T
T
G
D
---------
V
L
G
T
P
F
F
-
L
M
D
Y
V
E
G
V
V
-
P
P
D
V
M
-
P
YTFGDNWFA
D
---------
A
---
P
A
E
R
Q
R
Q
L
--
Q
D
A
T
V
A
A
L
A
T
L
H
S
I
--
P
N
A
Q
N
T
F
-
S
F
L
T
-------
D
-
T
T
L
H
R
H
F
N
--
W
-
V
R
S
-
W
Y
-
D
-
F
A
V
E
G
---
I
-
G
R
S
P
---
L
L
E
R
T
---
F
E
W
L
Q
-------------
S
H
W
----
P
D
D
A
A
A
-
R
---
E
P
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
F
------
Q
P
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
W
M
I
F
--------
A
H
R
---------------
V
F
---------------
Q
E
---------------
L
-------------
A
G
L
A
TLPGLPEV
M
R
E
D
D
-------
V
R
A
T
Y
Q
A
L
-------------------------------------------------------------------------------------------------------------------
50
SP3
64.73
10%
-21
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-----------------
G
M
K
E
L
L
S
T
M
D
L
D
T
D
A
N
T
I
P
E
L
K
-----
E
R
A
H
M
L
C
A
R
-----
F
L
G
G
A
W
K
T
V
PL
E
H
L
R
I
S
--
R
I
K
G
G
M
S
--
N
M
L
F
L
-
C
R
L
S
E
V
Y
P
----------
P
I
-
R
N
E
P
N
K
V
L
L
R
V
Y
F
N
P
------
E
T
-------------------------------
E
S
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
H
--
L
G
P
K
L
Y
G
----------------
I
F
S
G
G
R
-
L
E
E
Y
I
P
S
-
R
-
P
L
S
C
H
-
E
---------
I
---------
S
---
L
A
----
H
M
--
S
T
K
I
A
K
R
V
A
K
V
H
Q
L
-------
E
V
P
I
W
K
E
--
P
-
D
Y
L
C
-
E
A
L
Q
R
W
L
K
Q
L
T
-
G
T
V
-
D
A
-
E
-
H
R
F
D
L
--
P
E
-
E
C
G
V
---
S
S
V
N
C
L
D
L
A
R
E
L
E
F
L
R
A
--------
H
I
S
---------
L
S
K
S
---
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
R
--------
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
--------
E
W
T
IDYDIDEAPF
Y
K
I
Q
T
E
N
---------------
F
P
---------------
E
-------------
N
-----------
D
Q
M
L
E
-------
F
F
L
N
Y
L
R
E
Q
G
N
T
R
E
N
---
E
-
L
Y
K
K
S
--
E
D
L
V
Q
E
T
L
P
F
--
V
----------
P
V
S
--
H
F
F
W
G
V
W
G
L
L
Q
V
E
-
L
S
P
V
G
F
G
--------
F
A
D
Y
G
R
D
R
L
S
L
Y
F
--
K
-------
H
K
Q
L
L
K
N
L
A
-------
38
HHSearch
64.36
15%
-46
- C4 -
-
3ATT
2
Y3168_MYCTU
A:
[4-297]
-----------------------------------
A
V
I
S
-----
R
W
L
S
S
V
L
P
G
-----
G
A
-----
A
P
--
E
-
V
T
V
E
SG
V
D
S
T
--
G
M
S
S
E
T
I
I
-
L
T
A
-
R
W
Q
Q
----------
D
G
-
R
S
I
Q
Q
K
L
V
A
R
V
A
P
A
A
------
E
D
V
P
V
---------------------
F
P
T
Y
-----
R
L
D
H
Q
F
E
V
I
R
L
V
G
E
L
T
D
V
P
V
P
R
V
R
W
I
E
T
T
G
D
---------
V
L
G
T
P
F
F
-
L
M
D
Y
V
E
G
V
V
-
P
P
D
V
M
-
P
YTFGDNWFA
D
---------
A
---
P
A
E
R
Q
R
Q
L
--
Q
D
A
T
V
A
A
L
A
T
L
H
S
I
--
P
N
A
Q
N
T
F
-
S
F
L
T
-------
D
-
T
T
L
H
R
H
F
N
--
W
-
V
R
S
-
W
Y
-
D
-
F
A
V
E
G
---
I
-
G
R
S
P
---
L
L
E
R
T
---
F
E
W
L
Q
-------------
S
H
W
----
P
D
D
A
A
A
-
R
---
E
P
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
F
------
Q
P
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
W
M
I
F
--------
A
H
R
---------------
V
F
---------------
Q
E
---------------
L
-------------
A
G
L
A
TLPGLPEV
M
R
E
D
D
-------
V
R
A
T
Y
Q
A
L
-------------------------------------------------------------------------------------------------------------------
29
HHSearch
64.25
16%
-38
- C4 -
-
2PUL
1
MTNK_BACSU
A:
[12-308]
------------------------------------
L
N
E
-----
S
S
A
V
A
L
A
V
K
-----
L
-
G
L
--------
T
L
T
C
Q
--
E
I
G
D
--
G
N
L
N
Y
V
F
H
-
I
Y
----------------------
D
R
A
L
I
I
K
Q
A
V
P
Y
------
A
K
V
--
E
-----------------
S
W
P
L
T
I
D
-----
R
A
R
I
E
S
S
A
L
I
R
Q
G
E
H
V
P
H
L
V
P
R
V
F
Y
S
D
T
--------------
E
M
A
V
T
-
V
M
E
D
L
S
H
L
K
I
A
R
K
G
L
-
I
E
G-------
E
---------
N
---
Y
P
----
H
L
--
S
Q
H
I
G
E
F
L
G
K
T
L
F
Y
--
S
S
D
Y
A
L
E
P
K
V
K
K
Q
L
V
-
K
Q
F
T
N
P
E
L
C
D
I
T
E
R
L
V
-
F
T
D
P
F
F
-
D
H
D
T
N
D
F
--
E
E
-
E
L
R
P
---
F
V
E
K
L
W
N
-
N
D
S
V
K
I
-
E
A
--------
A
K
L
K
----
K
S
F
-
L
T
-
S
---
A
E
T
L
I
H
G
D
L
H
T
G
S
I
F
A
S
E
-------
H
E
T
K
V
I
D
P
E
F
A
F
Y
G
P
I
G
F
D
V
G
Q
F
I
A
--------
N
L
F
---------------
L
N
---------------
A
L
S
--------------
R
-------------
D
-----------
G
A
D
R
E
-------
P
L
Y
E
H
V
N
Q
V
W
E
T
F
E
--------
E
T
F
--
S
E
A
W
Q
K
D
S
----------------------------------------------------------------------------------------
30
HHSearch
63.76
16%
-40
- C4 -
-
2OLC
3
MTNK_BACSU
A:
[12-308]
------------------------------------
L
N
E
-----
S
S
A
V
A
L
A
V
K
-----
L
-
G
L
--------
T
L
T
C
Q
--
E
I
G
D
--
G
N
L
N
Y
V
F
H
-
I
Y
----------------------
D
R
A
L
I
I
K
Q
A
V
P
Y
------------------------------
W
P
L
T
I
D
-----
R
A
R
I
E
S
S
A
L
I
R
Q
G
E
H
V
P
H
L
V
P
R
V
F
Y
S
D
T
--------------
E
M
A
V
T
-
V
M
E
D
L
S
H
L
K
I
A
R
K
G
L
-
I
E
G-------
E
---------
N
---
Y
P
----
H
L
--
S
Q
H
I
G
E
F
L
G
K
T
L
F
Y
--
S
S
D
Y
A
L
E
P
K
V
K
K
Q
L
V
-
K
Q
F
T
N
P
E
L
C
D
I
T
E
R
L
V
-
F
T
D
P
F
F
-
D
H
D
T
N
D
F
--
E
E
-
E
L
R
P
---
F
V
E
K
L
W
N
-
N
D
S
V
K
I
-
E
A
--------
A
K
L
K
----
K
S
F
-
L
T
-
S
---
A
E
T
L
I
H
G
D
L
H
T
G
S
I
F
A
S
E
-------
H
E
T
K
V
I
D
P
E
F
A
F
Y
G
P
I
G
F
D
V
G
Q
F
I
A
--------
N
L
F
---------------
L
N
---------------
A
L
S
--------------
R
-------------
D
-----------
G
A
D
R
E
-------
P
L
Y
E
H
V
N
Q
V
W
E
T
F
E
--------
E
T
F
--
S
E
A
W
Q
K
D
S
----------------------------------------------------------------------------------------
63
Fugue
62.19
14%
-7
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-----------------
G
M
K
E
L
L
S
T
M
D
L
D
T
D
A
N
T
I
P
E
L
K
-----
E
R
A
H
M
L
C
A
R
-----
F
L
G
G
A
W
K
T
V
--
P
L
E
H
L
R
--
I
S
R
I
K
G
G
M
S
N
M
L
F
L
-
C
R
L
S
E
V
Y
P
----------
P
I
-
R
N
E
P
N
K
V
L
L
R
V
Y
F
N
P
------
E
T
E
S
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
H
L
G
P
K
L
Y
G
I
F
S
G
----------------
G
R
L
E
E
Y
I
P
S
R
P
L
S
C
H
E
I
S
L
----------------------------------------------------------
A
----
H
M
--
S
T
K
I
A
K
R
V
A
K
V
H
Q
L
--
E
V
P
I
W
K
-----
E
--
P
-
D
Y
L
C
-
E
A
L
Q
R
W
L
K
Q
L
T
-
G
T
V
-
D
A
-
E
-
H
R
F
D
L
--
P
E
-
E
C
G
V
---
S
S
V
N
C
L
D
L
A
R
E
L
E
F
L
R
A
--------
H
I
S
L
----
S
K
-----
S
---
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
R
--
L
------
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
IDYDI
D
E
A
---------------
P
F
---------------
Y
K
---------------
I
-------------
Q
-----------
T
E
N
F
P
-------
E
N
D
Q
M
L
E
F
F
L
N
Y
L
R
E
---
Q
G
N
T
R
E
N
--
E
L
Y
K
K
S
E
D
L
V
Q
E
T
----------
L
P
F
--
V
P
V
S
H
F
F
W
G
V
W
G
L
-
L
Q
V
E
L
S
P
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
--
L
-------
L
K
N
L
A
-----------
46
HHSearch
61.82
15%
-40
- C4 -
-
5IGI
3
?
A:
[5-254]
----------------------------------
T
T
A
D
T
-----
S
Q
L
Y
A
L
A
A
R
-----
H
-
G
L
K
L
-
H
-----
G
P
L
T
--
V
N
E
L
--
G
L
D
Y
R
I
V
I
-
A
T
V
-
D
D
------------------
G
R
R
W
V
L
R
I
P
R
R
A
------
E
V
S
--------------------------
A
-----
K
V
E
P
E
A
R
V
L
A
M
L
K
N
R
L
P
F
A
V
P
D
W
R
V
A
N
A
E
L
V
A
Y
-------
P
M
L
E
D
S
T
-
A
-
V
I
Q
P
G
S
S
-
T
P
D
W
V
V
P
---------
Q
---------
D
---
S
E
----
V
F
--
A
E
S
F
A
T
A
L
A
A
L
H
A
V
--
P
I
S
A
A
V
D
A
G
M
L
I
----
R
T
P
--
T
Q
A
R
Q
-----
K
-
V
A
D
-
D
V
-
D
-
R
V
R
R
E
--
F
V
-
V
N
D
K
---
R
L
H
R
----
W
Q
R
W
L
D
------------
D
D
-----
S
S
--
W
P
-
D
---
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T
-----
E
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
L
M
--------
V
F
G
---------------------------------------------------------------
E
-----------
E
G
L
A
K
-------
L
L
L
T
Y
E
A
A
-------------------------------------------------------------------------------------------------------------------
61
Fugue
60.29
12%
34
- C4 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
------------------
S
A
F
T
-----------
F
Q
T
L
H
P
-----
D
T
I
M
D
A
L
F
E
H
GIRV
D
S
G
L
T
P
L
N
S
--
Y
E
N
R
V
Y
--
Q
F
Q
D
E
D
R
R
R
F
V
V
K
F
-
Y
------------------------
R
P
E
R
W
T
A
D
Q
I
L
------
E
E
H
Q
F
A
L
Q
L
V
N
D
E
V
P
V
A
A
P
V
A
------------
F
N
G
Q
T
L
L
N
H
----------------------------------
Q
G
F
Y
F
A
-
V
F
P
S
V
G
G
R
Q
-
F
-----
E
---------
A
---------
D
---
N
I
----
D
Q
--
M
E
A
V
G
R
Y
L
G
R
M
H
Q
T
--
G
R
K
----
Q
L
F
I
H
--
R
-
P
T
I
G
-
L
N
E
Y
L
I
E
P
R
K
L
-
F
E
D
-
A
T
-
L
-
I
P
S
G
L
--
K
A
-
A
F
L
K
---
A
T
D
E
L
I
A
A
V
T
A
H
W
R
E
D
F
---------------------------
T
V
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
G
--------
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
L
L
N
--------
G
-----------------
D
K
---------------
A
E
---------------
Q
-------------
R
-----------
M
Q
L
E
T
-------
I
I
E
A
Y
E
E
F
S
E
F
D
T
A
E
---
I
G
L
I
E
P
L
--
R
A
M
R
L
V
Y
Y
L
A
W
L
M
----------
R
R
W
--
A
-----
D
P
A
F
P
K
N
-
F
P
W
L
T
G
------
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
--
V
-------
L
Q
E
P
P
L
Q
L
T
P
M
Y
----
37
HHSearch
59.63
14%
-60
- C4 -
-
5UXD
2
?
A:
[3-251]
----------------------------------
M
P
E
D
L
-----
D
A
L
L
D
L
A
A
R
-----
H
G
L
D
L
-
D
G
-----
G
T
L
R
--
T
E
E
I
--
G
L
D
F
R
V
A
F
-
A
R
A
-
H
D
------------------
G
G
D
W
V
L
R
L
P
R
R
P
------
D
V
L
--------------------------
E
-----
R
A
A
V
E
G
R
L
L
A
M
L
A
P
H
L
D
V
A
V
P
D
W
R
I
S
T
----------------
S
E
L
I
-
A
Y
P
L
L
P
G
S
P
-
G
L
T
V
A
-
A
---------
D
G
E
V
S
W
HVDM
A
---
S
T
----
V
Y
--
A
R
S
L
G
S
V
V
A
Q
L
H
A
V
--
D
A
E
A
A
A
A
T
G
-
I
E
--
V
-
R
S
-
P
-
A
Q
V
R
G
-----
A
-
W
R
Q
-
D
L
-
A
-
R
V
G
A
E
--
F
--
E
I
A
P
------
A
L
R
E
R
W
E
A
W
L
A
------------
D
D
-----
G
C
--
W
P
-
G
---
H
S
V
L
T
H
G
E
L
Y
P
A
H
T
L
V
E
D
E
------
R
I
T
A
V
L
D
W
T
T
A
A
V
G
D
P
A
K
D
L
M
F
H
Q
V
--------
S
A
----------------
P
-----------------------------------------------
S
-----------
A
I
F
E
V
-------
A
L
Q
A
Y
A
E
G
-------------------------------------------------------------------------------------------------------------------
45
HHSearch
59.37
15%
-35
- C4 -
-
5IGH
-
?
A:
[5-254]
----------------------------------
T
T
A
D
T
-----
S
Q
L
Y
A
L
A
A
R
-----
H
-
G
L
K
L
-
H
-----
G
P
L
T
--
V
N
E
L
--
G
L
D
Y
R
I
V
I
-
A
T
V
-
D
D
------------------
G
R
R
W
V
L
R
I
P
R
R
A
------
E
V
S
--------------------------
A
-----
K
V
E
P
E
A
R
V
L
A
M
L
K
N
R
L
P
F
A
V
P
D
W
R
V
A
N
A
E
L
V
A
Y
-------
P
M
L
E
D
S
T
-
A
M
V
I
Q
P
G
S
S
-
T
P
D
W
V
V
P
---------
Q
---------
D
---
S
E
----
V
F
--
A
E
S
F
A
T
A
L
A
A
L
H
A
V
--
P
I
S
A
A
V
D
A
G
M
L
I
----
R
T
P
--
T
Q
A
R
Q
-----
K
-
V
A
D
-
D
V
-
D
-
R
V
R
R
E
--
F
V
-
V
N
D
K
---
R
L
H
R
----
W
Q
R
W
L
D
------------
D
D
-----
S
S
--
W
P
-
D
---
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T
-----
E
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
L
M
--------
V
F
G
---------------------------------------------------------------
E
-----------
E
G
L
A
K
-------
L
L
L
T
Y
E
A
A
-------------------------------------------------------------------------------------------------------------------
44
HHSearch
58.77
12%
-35
- C4 -
-
3MES
2
?
B:
[50-350]
-------------------------------------
D
T
-----
E
I
I
I
G
I
C
R
K
-----
N
I
P
G
W
K
E
I
N
E-
S
Y
I
E
V
K
--
Q
I
F
S
--
G
L
T
N
Q
L
F
V
-
V
S
I
-
V
N
E
---------------
L
K
H
P
R
I
L
F
R
I
Y
G
K
H
------
V
--
F
-------------------------
Y
-----
D
S
K
V
E
L
D
V
F
R
Y
L
S
N
I
-
N
I
A
-
P
N
I
I
A
D
F
P
----------------
E
G
R
-
I
E
E
F
I
D
G
E
P
-
L
T
T
K
Q
-----------
L
---------
Q
---
L
T
----
H
I
--
C
V
E
V
A
K
N
M
G
S
L
H
I
I
--
N
S
K
R
A
D
F
P
S
R
F
D
--
K
E
P
I
L
F
-
K
R
I
Y
L
W
R
E
--
E
-
A
K
I
-
Q
V
-
S
-
K
N
N
-
Q
--
I
---
D
K
E
---
L
Y
S
K
I
L
E
E
I
D
Q
L
E
E
-
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
-
L
Y
S
-
P
A
-
F
---
S
L
V
F
A
H
N
D
L
Q
E
N
N
L
L
Q
T
Q
-------
N
N
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
A
D
I
A
N
Y
F
C
--------
E
Y
I
---------------
Y
D
---------------
Y
C
SEKQPY
F
K
F
K
YEDYP
C
-------------
E
-----------
E
L
R
K
L
-------
F
I
S
V
Y
L
S
Q
T
L
-----------------------------------------------------------------------------------------------------------------
42
HHSearch
56.98
14%
-24
- C4 -
-
6EF6
2
?
A:
[46-292]
-------------------------------------------------------------------------
L
R
--
L
L
-
N
--
L
S
E
N
A
T
Y
L
-
V
E
D
-
G
-------------------
E
H
Q
S
I
L
R
V
H
R
Q
D
------
Y
H
Q
P
-------------------------
H
-----
E
I
E
S
E
L
D
W
L
A
A
L
R
T
D
S
D
V
T
V
P
T
V
V
P
A
R
D
G
R
R
-
V
V
T
V
D
P
A
D-
V
P
R
H
V
V
-
H
F
E
M
V
G
G
A
E
-
P
D
E
E
------------
S
---------
L
---
T
L
----
D
D
--
F
Q
T
L
G
R
I
T
A
S
L
H
E
H
--
S
Q
R
W
T
R
P
-
A
G
F
G
--
R
-
F
S
W
---
D
W
E
H
C
L
G
--
D
-
T
P
R
--
W
-
G
-
R
W
Q
D
A
EG
V
G
A
S
E
T
A
---
L
L
T
R
A
Q
D
L
L
H
R
K
L
-------------
E
E
Y
----
G
S
--
G
P
-
D
---
R
Y
G
L
I
H
A
D
L
R
L
A
N
L
L
V
D
S
S
--
T
-
P
Q
R
T
I
T
V
I
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
G
T
A
V
S
--------
F
I
E
---------------
H
D
---------------
P
R
---------------
L
-------------
G
-----------
E
W
Q
E
S
-------
W
V
A
G
Y
R
S
R
-------------------------------------------------------------------------------------------------------------------
43
HHSearch
56.78
12%
-35
- C4 -
-
3MES
3
?
A:
[50-351]
-------------------------------------
D
T
-----
E
I
I
I
G
I
C
R
K
-----
N
I
P
G
W
K
E
I
N
E-
S
Y
I
E
V
K
--
Q
I
F
S
--
G
L
T
N
Q
L
F
V
-
V
S
I
-
V
N
E
---------------
L
K
H
P
R
I
L
F
R
I
Y
G
K
H
------
V
-
K
F
-------------------------
Y
-----
D
S
K
V
E
L
D
V
F
R
Y
L
S
N
I
-
N
I
A
-
P
N
I
I
A
D
F
P
----------------
E
G
R
-
I
E
E
F
I
D
G
E
P
-
L
T
T
K
Q
-----------
L
---------
Q
---
L
T
----
H
I
--
C
V
E
V
A
K
N
M
G
S
L
H
I
I
--
N
S
K
R
A
D
F
P
S
R
F
D
--
K
E
P
I
L
F
-
K
R
I
Y
L
W
R
E
--
E
-
A
K
I
-
Q
V
-
S
-
K
N
N
----
I
---
D
K
E
---
L
Y
S
K
I
L
E
E
I
D
Q
L
E
E
-
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
-
L
Y
S
-
P
A
-
F
---
S
L
V
F
A
H
N
D
L
Q
E
N
N
L
L
Q
T
Q
-------
N
N
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
A
D
I
A
N
Y
F
C
--------
E
Y
I
---------------
Y
D
---------------
Y
C
SEKQPY
F
K
F
K
YEDYP
C
-------------
E
-----------
E
L
R
K
L
-------
F
I
S
V
Y
L
S
Q
T
L
-----------------------------------------------------------------------------------------------------------------
73
Fugue
56.62
12%
44
- C4 -
-
2QG7
-
?
A:
[50-458]
YPITESNLRILEGED
R
S
E
K
A
K
E
L
L
K
K
Y
V
S
N
V
F
E
N
E
K
T
L
Y
-----
I
Y
C
K
Y
V
M
L
H
-----
Y
G
K
D
L
V
N
P
N
--
E
V
D
S
L
E
--
F
Q
I
I
N
G
T
---------
N
I
-
L
I
K
V
----------
K
D
-
M
S
K
Q
A
K
Y
L
I
R
L
Y
G
-------------------
P
T
D
E
I
I
N
R
E
R
E
K
K
I
S
C
I
L
Y
N
K
-
N
I
A
K
K
I
Y
V
F
F
--
T
N
G
R
I
E
E
F
M
D
G
Y
A
L
S
R
E
D
I
K
N
----------------------------------------------------------
P
----
K
F
--
Q
K
L
I
A
K
N
L
K
L
L
H
D
I
--
K
L
N
E
N
L
Y
K
E
L
Q
V
--
T
-
Q
K
V
P
-
G
T
R
P
S
F
L
W
N
T
I
-
W
K
Y
-
F
H
-
L
-
L
N
E
E
R
--
K
K
-
I
C
S
F
---
D
A
K
A
N
I
L
K
L
I
D
F
D
V
L
R
D
--------
S
I
V
E
----
V
E
S
-
L
C
K
R
E
NS
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
T
V
G
--
E
G
D
S
I
--
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
--------
E
Y
A
---------------
G
-----------------
F
---------------
N
-------------
C
-----------
D
W
D
L
T
-------
P
S
K
E
E
E
Y
H
F
I
M
H
Y
L
G
---
T
D
D
E
E
L
I
--
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
----------
S
H
I
N
W
G
L
W
S
L
L
Q
G
M
H
S
F
D
-
F
I
N
Y
G
M
T
R
L
T
A
S
-----------------------------
C
L
P
I
F
R
S
K
V
----
66
Fugue
55.59
15%
34
- C1 -
-
5L3T
-
THP1_YEAST
B:
[1-455]
-----------------
M
D
M
A
N
Q
L
L
D
E
L
A
H
G
N
F
S
-
H
L
T
L
NLSQN
G
R
E
I
A
I
L
Q
K
-----
Q
L
T
G
F
D
D
K
Q
--
L
E
T
F
V
E
--
Q
H
P
A
M
P
N
D
T
R
F
K
I
M
-
C
T
S
-
F
L
N
Y
A
R
D
VDPWSAW
S
S
-
S
D
L
I
F
E
F
Y
Q
C
L
I
N
C
L
INDNAP
H
I
E
M
L
I
P
V
A
T
R
E
T
E
F
I
I
N
L
A
G
K
L
D
S
F
-
H
L
Q
L
-----
H
T
R
S
H
Q
F
L
S
H
I
S
S
I
L
S
R
L
F
N
S
I
K
P
P
R
G
N
A
S
-
S
-------
T
N
I
P
G
K
Q
R
I
L
L
Y
L
V
N
K
L
-
N
N
I
Y
F
-
R
---------
I
---------
E
---
S
P
----
Q
L
--
C
S
N
I
F
K
N
F
Q
P
K
S
M
L
--
A
H
F
N
E
Y
--
Q
L
D
Q
--
Q
-
I
E
Y
R
-
Y
L
L
G
R
Y
Y
L
L
N
S
Q
V
H
N
-
A
F
-
V
-
Q
F
N
E
A
--
F
Q
-
S
L
L
N
LPL
T
N
Q
A
I
T
R
N
G
T
R
I
L
N
Y
M
I
--------
P
T
G
L
I
L
GK
M
V
K
-
W
G
P
L
---
R
P
F
L
S
Q
E
T
I
D
N
W
S
V
L
Y
K
H
V
--
R
Y
G
N
I
Q
G
V
S
L
W
L
R
Q
N
E
R
H
L
C
A
R
Q
L
L
I
V
L
L
--------
E
K
L
---------------
P
M
---------------
V
T
---------------
Y
-------------
R
-----------
N
L
I
K
T
-------
V
I
K
S
W
T
T
----
E
W
G
Q
---
N
K
L
P
Y
S
L
I
E
R
V
L
Q
L
S
I
G
P
T
F
E
D
PGAQEITIYN
G
I
H
--
S
P
K
N
V
E
N
V
L
V
T
L
I
-
N
L
G
L
L
R
A
N
C
F
P
Q
L
Q
L
C
V
V
K
K
T
T
M
I
Q
E
I
V
PP
V
-------
N
E
R
I
T
K
M
F
P
A
H
S
HVLW