@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q12K05_SHEDO: (2019-02-01 )
MMKTEPSINLSLKRLVENPSYADACDILDERPLEFWLPTIEVILSQHQLAKKTVLRISNGSNALFDIDNEYILKLVPPNWDYQGISEVTSLTLLNLANHSENLSLAVPKMIGFGRVDNWFYVIMTKLKGLSMATVWPDLNTAQKLPLVKQLGQFMTELHQITSTQAFTPDPRLSVDWPEYIKGLISDSVPRHARKGVSPELVTQISDYLQAADSDFNDIHAVFIHMDLHPWNLMVEKHHGHYRLCGVVDFGDALVGNCQLLELATPIIFVCQGNKTLIDELVANYSPLNEVYLDRQVLQRQLMAVSLIRPACDFNFVLQQVPQSGKRDSWQAIAKQLFPLYKGRPA
Atome Classification :
(20 SA)
-----....-.....10........20........30......-..40.--.....---..-50-.-.......------.60....-...----.------------.70---.......-..-80-.-......-..90-........100--.......110.---..-.----------...120.......------130.---.-.-.-...140---.....-....150.....-..160.......-170-.-.----...-----------.-.--..180.--......190----------..-.-...----.200........210..--.--.-...220.--........230.......240.......250.......260......-------------.270.-----.-.-----.---------------------.--------....280....--.--...290.......300--------.......-.310.--..------....320.......330...-----....340....------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----MMKT-EPSI
N
L
S
L
K
R
L
VENPSYA
D
A
C
D
I
L
DER
P
L
E
F
W
L
-
P
T
I
E
V
--
I
L
S
Q
H
---
Q
L
-
A
--
K
-
K
T
V
L
R
IS------NG-S
N
A
L
-
F
DI----D------------N
E
----
Y
I
L
K
LVP-PN-W--D-Y
Q
G
I
S
E
-
V
T
S
L
-
T
L
L
NLANHSEN--
L
S
LA
V
P
K
MIGF---GR-V----------D
N
W
F
Y
V
I
M
T
K
LKG------
L
S
M
A
---
T
-V-W-PDL
N
-----
T
A
Q
K
L
-
P
L
V
K
Q
L
G
Q
F
M
T
E
-
L
H
Q
I
TSTQAFTP-D---P-R----LSV-----------D-
W
--
P
E
Y
I
K
G
--
L
I
SDSV
P
R
H
----------
A
R-K-GV
S
----
P
E
-
L
V
T
Q
I
S
D
Y
L
Q
A
ADS--D--F-N
D
I
H
--
A
--
V
F
I
H
M
DLHPW
N
L
M
V
EKHHG
H
Y
R
L
C
G
V
V
DFG
D
A
L
VGN
C
Q
L
L
E
LAT
P
I
I
-------------
F
V
--C-----Q-G-----
N
---------------------
K
--------
T
L
I
D
E
L
-
V
ANY--S--
P
L
N
E
V
Y
L
D
R
Q
V
L
Q
R
Q
---------
L
M
A
V
S
L
I-RPAC
D
--
F
N
------
F
V
L
Q
QVPQSGKR
D
S
W
Q
A
I
A
K
-----
Q
L
F
P
LYKGRPA------------------------
29
Fugue
85.58
14%
-47
- C3 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
----------------------
S
A
F
T
F
Q
T
----
L
H
P
D
T
I
M
D
A
L
-
F
E
H
G
I
-----------
R
-
V
--
D
-
S
G
L
T
P
L
N
------
S
Y
-
E
N
R
V
-
Y
Q
F
----
Q
------------
D
E
DR
R
R
F
V
V
K
F
Y
R
-
P
E
R
W
--
T
-
A
D
Q
I
L
E
-
E
H
Q
F
-
A
L
Q
L
V
N
D
E
V
P
V
--
A
A
P
V
A
F
N
G
Q
T
L
---
L
N
-
H
----------
Q
G
F
Y
F
A
V
F
P
S
V
G
G
------
R
Q
F
-------------------
E
A
D
N
I
-
D
Q
M
E
A
V
G
R
Y
L
G
R
-
M
H
Q
T
G
R
K
Q
L
F
I
H
-
R
---
P
-
T
----
I
G
L
-----------
N
-
E
YL
I
E
P
R
K
L
--
F
E
D
A
T
L
I
P
S
----------
G
L
-
K
-
A
A
F
----
L
K
-
A
T
D
E
L
I
A
A
V
T
A
H
W
R
-------
E
D
F
T
--
V
--
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
G
------
P
M
F
V
D
L
D
D
A
R
N
G
-
P
A
V
Q
D
L
W
M
L
L
N
-------------
G
D
--
K
-----
A
-
E
-----
Q
---------------------
R
--------
M
Q
L
E
T
I
-
I
E
A
Y
--
E
--
E
F
S
E
F
D
T
A
E
I
G
L
I
E
P
---------
L
R
A
M
R
L
V
-
Y
Y
L
A
W
--
L
M
R
R
WAD
P
A
F
P
K
N
F
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
-----
T
F
I
E
Q
A
K
V
L
Q
E
PPLQLTPMY---------------
55
HHSearch
78.42
16%
-41
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[8-281]
-----------------------------------------
T
E
-
D
E
L
R
N
--
F
L
T
Q
Y
---
D
V
-
G
--
S
L
T
S
Y
K
G
I
A
------
E
---
N
S
N
-
F
L
L
H
T
T-
K
------------
D
P
----
L
I
L
T
L
Y
E
-
K
-----
K
-
N
D
L
P
F
F
-
L
G
L
M
-
Q
H
L
A
-----
A
K
---
G
L
S
C
P
L
P
L
P
R
---
K
D
-
G
EL
L
G
E
L
----
S
G
R
P
A
A
L
I
S
F
L
E
G
------
M
W
L
R
---
K
-
P
---------------
E
A
-
K
H
C
R
E
V
G
K
A
L
A
A
-
M
H
L
A
S
E
G
F
E
I
K
R
P
N
---
A
-
L
----
S
V
D
-----------
G
-
W
--
K
V
L
W
D
K
--
S
E
E
R
-
A
D
-----------------
E
V
E
----
K
G
-
L
R
E
E
I
R
P
E
I
D
Y
L
A
A
--
H
--
W
P
K
D
L
P
--
A
--
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
D
E
----
L
S
G
L
I
D
F
Y
F
A
C
N
D
-
L
L
A
Y
D
V
S
I
C
L
N
-------------
A
W
--
C
-----
F
-
E
KDGAY
N
---------------------
V
--------
T
K
G
K
A
L
-
L
E
G
Y
--
Q
--
S
V
---
R
P
L
S
E
A
E
L
E
A
---------
L
P
L
L
S
R
G
-
S
A
L
R
F
--
F
L
------
T
R
L
---------------------------------------------------------
67
SP3
78.16
12%
-27
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
------------
G
M
K
E
L
L
S
T
M
D
L
D
T
D
A
N
T
I
P
E
L
K
----------
E
R
A
H
M
--
L
C
A
R
F
LGG
A
W
-
K
--
T
-
V
P
L
E
H
L
R
I
S
R
I
K
G
G
M
-
S
N
M
L
-
F
L
C
----
R
L
S
EVYPPIRNEP
N
K
----
V
L
L
R
V
Y
F
N
P
E
-
T
--
E
-
S
H
L
V
A
E
-
S
V
I
F
-
T
L
L
S
E
R
H
L
G
---------
P
K
L
Y
G
I
---
F
S
-
G
--------------
G
R
L
E
E
Y
I
P
S
------
R
P
L
-----------
S
C
H
-----
E
I
S
L
A
-
H
M
S
T
K
I
A
K
R
V
A
K
-
V
H
Q
L
E
------
V
-
P
---
I
-
W
----
K
E
P
-----------
D
-
Y
--
L
C
E
A
L
Q
--
R
W
L
K
Q
L
T
G
T
V
DAE
H
R
F
D
L
P
E
E
-
C
-
G
V
S
----
S
V
-
N
C
L
D
L
A
R
E
L
E
F
L
R
A
--
H
--
I
-
S
L
S
K
--
S
PV
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
R
L
V
------
L
I
D
F
E
Y
A
S
Y
-
N
Y
R
A
F
D
F
A
N
H
F
I
-------------
E
W
--
T
-----
I
-
D
-----
Y
DIDEAPF
Y
K
I
Q
TENFPE
N
D
Q
M
L
--------
E
F
F
L
N
Y
-
L
R
E
Q
--
G
NT
R
E
N
E
L
Y
K
K
S
E
D
L
V
Q
E
---------
T
L
P
F
V
P
V
-
S
H
F
F
W
--
G
V
------
W
G
L
L
Q
V
E
L
S
P
V
G
F
G
F
A
D
Y
G
R
-----
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA------------------
34
Fugue
76.44
15%
-21
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
-------------------------------
T
D
I
T
E
D
E
L
R
N
F
L
-
T
Q
Y
D
V
GS
L
T
S
Y
K
---
G
I
-
A
--
E
-
N
S
N
F
L
L
H
------
T
T
-------------
K
------------
D
P
----
L
I
L
T
L
Y
E
-
K
K
-------
N
D
L
P
F
-
F
L
G
L
M
Q
H
L
A
A
K
G
L
S
C
P
--
L
P
L
P
R
K
D
G
E
L
L
---
G
E
-
L
----------
S
G
R
P
A
A
L
I
S
F
L
E
G
M
-----
W
L
--------------------
R
K
P
E
A
-
K
H
C
R
E
V
G
K
A
L
A
A
M
H
L
A
S
E
G
F
E
I
K
R
P
-
N
---
A
-
L
----
S
V
D
-----------
G
-
W
--
K
V
L
W
D
K
--
S
E
E
R
A
D
E
------------------
V
E
----
K
G
-
L
R
E
E
I
R
P
E
I
D
Y
L
A
A
--
H
--
W
P
K
D
L
P
--
A
--
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
D
----
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
-
L
A
Y
D
V
S
I
C
L
N
-------------
A
W
--
C
FEKDG
A
-
Y
-----
N
---------------------
V
--------
T
K
G
K
A
L
-
L
E
G
Y
--
Q
--
S
V
R
P
L
S
E
A
E
L
E
A
L
P
L
---------
L
S
R
G
S
A
L
-
R
F
F
L
T
R
L
Y
D
------
W
L
T
T
P
A
G
A
L
V
V
K
K
D
P
L
E
Y
L
R
-----
K
L
R
F
H
R
T
I
A
N
V
AEYGLA------------------
31
Fugue
74.68
14%
-88
- C3 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
--------
A
-
K
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
------------------------
D
T
E
---
G
M
-
S
--
P
-
A
K
V
Y
K
L
V
------
G
E
-------------
N
------------
E
N
----
L
Y
L
K
M
T
D
-
S
R
-
Y
--
K
-
G
T
T
Y
D
V
-
E
R
E
K
-
D
M
M
L
W
L
E
G
K
------
L
P
V
P
K
V
L
H
F
---
E
R
-
H
----------
D
G
W
S
N
L
L
M
S
E
A
D
G
------
V
L
C
S
---
E
-
E
-
Y
-
E
D
-------
E
Q
S
P
E
-
K
I
I
E
L
Y
A
E
C
I
R
L
-
F
H
S
I
D
I
S
D
C
-
P
Y
-
T
---
N
-
S
----
L
D
S
-----------
R
-
L
--
A
E
L
D
Y
L
--
L
N
N
D
L
A
D
V
D
----------
C
E
-
N
-
W
E
E
----
D
T
-
P
F
K
D
P
R
E
L
Y
D
F
L
K
T
--
E
--
K
-
P
E
E
E
--
L
--
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
----
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
--------------------------------------------------------------------------
K
W
Y
D
I
-
A
F
C
V
--
R
--
S
I
R
E
D
I
G
E
E
Q
Y
V
E
L
F
---------
F
D
L
L
G
-----------------------
I
K
P
D
W
E
K
I
K
Y
Y
I
L
L
D
-----
E
L
F
--------------------------------
39
Fugue
74.08
13%
-0
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
M
-
D
L
D
T
D
A
N
T
I
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
G
A
W
K
T
V
P
L
-
E
H
L
R
I
--
S
R
I
K
G
---
G
M
S
N
--
M
-
L
F
L
C
R
L
S
------
E
V
-
Y
P
P
I
-
R
N
E
----
P
------------
N
K
----
V
L
L
R
V
Y
F
-
N
P
-------
E
T
E
S
H
-
L
V
A
E
-
S
V
I
F
T
L
L
S
E
R
H
--
L
G
P
K
L
Y
G
I
F
S
G
---
G
R
-
L
----------
E
E
Y
------------------
I
P
---
S
-
R
-
P
-
L
S
C
H
-----
E
I
S
L
A
-
H
M
S
T
K
I
A
K
R
V
A
K
-
V
H
Q
-
L
E
V
P
I
W
K
E
-
P
---
D
-
Y
----
L
C
E
-----------
A
-
L
--
Q
R
W
L
K
Q
--
L
T
G
T
V
D
A
E
H
R
F
D
L
P-----
E
E
-
C
-
G
V
S
----
S
V
-
N
C
L
D
L
A
R
E
L
E
F
L
R
A
--
H
--
I
-
S
L
S
K
SP
V
--
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
R
------
L
V
L
I
D
F
-
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
IDYDIDEAPF
Y
K
--
I
-----
Q
-
T
-----
E
---------------------
N
FPE
N
D
Q
M
L
E
F
F
L
N
Y
-
L
R
E
Q
GN
T
--
R
E
N
E
L
Y
K
K
S
E
D
L
V
Q
E
---------
T
L
P
F
V
P
V
-
S
H
F
F
W
--
G
V
------
W
G
L
L
Q
V
E
L
S
P
V
G
F
G
F
A
D
Y
G
R
-----
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA------------------
53
HHSearch
71.94
17%
-2
- C3 -
-
4DCA
1
?
A:
[26-299]
-----------------------------------------
D
A
-
E
I
Y
E
H
--
L
N
K
-----
Q
I
-
K
--
I
-
N
E
L
R
Y
L
S
------
S
G
D
D
S
D
T
-
F
L
C
----
N
------------
E
Q
----
Y
V
V
K
V
P
K
-
R
D
-
S
V
-
R
-
I
S
Q
K
R
E
-
L
E
L
Y
-
R
F
L
E
-----
N
C
K-
L
S
Y
Q
I
P
A
V
V
Y
Q
---
S
---------------
D
R
F
N
I
M
K
Y
I
K
G
------
E
R
I
T
---
Y
E
Q
-
Y
-
H
K
L
S
-----
E
K
E
K
D
-
A
L
A
Y
D
E
A
T
F
L
K
E
-
L
H
S
I
E
I
D
C
--
S
V
-
S
L
F
S
D
-
A
----
L
V
N
-----------
K
-
K
--
D
K
F
L
Q
---
D
K
K
L
L
I
S
I
L
----------
E
K
E
Q
-
L
L
T
----
D
E
-
M
L
E
H
I
E
T
I
Y
E
N
I
L
S
--
N
AV
L
-
F
K
Y
T
--
P
--
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
N
N
R
----
L
F
G
V
I
D
F
G
D
F
N
V
G
-
D
P
D
N
D
F
L
C
L
L
D
-------------
C
S
--
T
D----
D
-
F
-----
G
---------------------
K
--------
E
F
G
R
K
V
-
L
K
Y
Y
--
Q
--
H
K
---
A
P
E
--
V
A
E
R
K
---------
A
E
L
N
D
V
Y
-
W
S
I
D
Q
--
I
I
------
Y
G
Y
E
R
K
D
-----------------------------------------------------
45
HHSearch
70.96
15%
-8
- C3 -
-
6EF6
2
?
A:
[27-324]
-----------------------------------------
D
V
-
T
I
A
Q
Q
--
A
L
T
H
Y
---
D
V
-
S
--
D
N
A
S
L
R
L
L
N
------
L
S
-
E
N
A
T
-
Y
L
V
E
D
G-
E
------------
H
Q
----
S
I
L
R
V
H
R
-
Q
D
-
Y
HQ
P
-
H
E
I
E
S
E
-
L
D
W
L
-
A
A
L
R
-----
T
D
--
S
D
V
T
V
P
T
V
V
P
A
---
R
D
-
G
RR
V
V
T
V
D
P
A
D
V
P
R
H
V
V
H
F
E
M
V
G
G
------
A
E
P
D
---
E
-
E
-
S
------------
L
T
L
-
D
D
F
Q
T
L
G
R
I
T
A
S
-
L
H
E
H
S
Q
R
W
T
R
P
A
-
G
-----
F
----
G
R
F
-----------
S
-
W
DW
E
H
C
L
G
D
TP
R
W
G
R
W
Q
D
A
E
----------
G
V
-
G
-
A
S
E
T
A
L
L
T
R
-
A
Q
D
L
L
H
R
K
L
E
E
Y
G
------
S
-
G
P
D
R
--
Y
--
G
L
I
H
A
D
L
R
L
A
N
L
L
V
D
S
S
T
-
P
Q
R
T
I
T
V
I
D
F
D
D
C
G
F
G
-
W
Y
F
Y
D
F
G
T
A
V
S
-------------
F
I
--
E
-----
H
-
D
PR---
L
---------------------
G
--------
E
W
Q
E
S
W
-
V
A
G
Y
--
R
--
S
R
---
R
E
L
P
A
A
D
E
A
M
---------
L
P
S
F
V
F
L
-
R
R
L
L
L
--
L
A
------
W
M
G
S
H
T
H
S
----------------------------------------------------
54
HHSearch
70.95
16%
10
- C3 -
-
3HAM
3
?
A:
[17-291]
--------------------------------------------------------------
K
--
I
-
N
E
L
R
Y
L
S
------
S
G
D
D
S
D
T
-
F
L
C
----
N
------------
E
Q
----
Y
V
V
K
V
P
K
-
R
D
-
S
V
-
R
-
I
S
Q
K
R
E
-
F
E
L
Y
-
R
F
L
E
-----
N
C
K-
L
S
Y
Q
I
P
A
V
V
Y
Q
---
S
---------------
D
R
F
N
I
M
K
Y
I
K
G
------
E
R
I
T
---
Y
-
E
Q
Y
-
H
K
L
S
-----
E
K
E
K
D
-
A
L
A
Y
D
E
A
T
F
L
K
E
-
L
H
S
I
E
I
D
C
--
S
V
-
S
LFS
D
-
A
----
L
V
N
-----------
K
-
K
--
D
K
F
L
Q
D
---
K
K
L
L
I
S
I
L
----------
E
K
-
E
Q
L
L
T
----
D
E
-
M
L
E
H
I
E
T
I
Y
E
N
I
L
N
--
N
AV
L
-
F
K
Y
T
--
P
--
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
N
N
R
----
L
F
G
V
I
D
F
G
D
F
N
V
G
-
D
P
D
N
D
F
L
C
L
L
D
-------------
C
S
--
T
D----
D
-
F
-----
G
---------------------
K
--------
E
F
G
R
K
V
-
L
K
Y
Y
--
Q
--
H
K
---
A
P
E
--
V
A
E
R
K
---------
A
E
L
N
D
V
Y
-
W
S
I
D
Q
--
I
I
------
Y
G
Y
E
R
K
D
R
E
M
L
I
K
G
V
S
E
L
L
Q
----------------------------------------
37
Fugue
70.60
15%
9
- C3 -
-
3JR1
3
?
A:
[14-309]
---N
L
Y
F
Q
G
M
W
K
S
I
S
Q
V
L
A
E
Q
F
G
A
Y
-----
Y
F
I
K
H
K
E
K
L
Y
S
G
E
M
N
E
I
W
L
--
I
N
D
E
V
---------
Q
-
T
V
F
V
K
I
N
------
E
R
-
S
Y
R
S
M
F
R
A
----
E
------------
A
D
----
Q
L
A
L
L
A
K
-
T
N
--------------------------------
S
I
N
V
P
L
V
Y
G
I
---
G
N
-
S
----------
Q
G
H
S
F
L
L
L
E
A
L
N
-----------------------
K
-----
S
K
N
K
Q
-
S
S
F
T
I
F
A
E
K
I
A
Q
-
L
H
Q
I
Q
G
P
D
K
Y
G
L
-
D
---
F
-
D
----
T
W
L
GP
I
Y
Q
P
N
D
W
QT
S
-
W
--
A
K
F
F
S
E
N-
R
I
G
W
Q
L
Q
I
C
----------
K
E
-
K
-
G
L
I
----
F
G
-
N
I
D
L
I
V
Q
I
V
A
D
T
L
S
--
K
--
H
-
N
P
-
K
--
P
--
S
I
L
H
G
N
L
W
I
E
N
C
I
Q
V
D
D
-------
K
I
F
V
C
N
P
A
C
Y
W
G
D
R
E
C
D
I
A
F
S
S
L
-------------
F
---------------------------------------
E
--------
P
F
P
T
N
F
-
Y
Q
R
Y
--
N
--
E
I
Y
P
L
E
E
G
Y
L
E
R
K
L
I
---------
Y
Q
L
Y
Y
L
L
-
N
F
S
Y
R
--
Y
Y
---------------
N
K
K
Q
S
Y
V
S
L
T
Q
-----
K
L
I
N
Q
I
L
H
K
--------------------------
48
HHSearch
70.58
17%
10
* C3 *
-
3TDW
1
?
A:
[11-283]
------------------------------------------------
M
--
I
M
T
Q
F
---
P
D
I
S
--
I
-
Q
S
V
E
S
L
G
------
E
G
F
R
N
Y
A
-
I
L
V
----
N
------------
G
D
----
W
V
F
R
F
P
K
-
S
Q
-
Q
G
-
A
-
D
E
L
N
K
E
-
I
Q
L
L
-
P
L
L
V
-----
G
C
--
V
K
V
N
I
P
Q
Y
V
Y
I
---
G
K
R
S
----------
D
G
N
P
F
V
G
Y
R
K
V
Q
G
------
Q
I
L
G
---
E
-
D
G
M
-
A
V
L
P
-----
D
D
A
K
D
-
R
L
A
L
Q
L
A
E
F
M
N
E
-
L
S
A
F
P
V
E
T
--
A
I
-
S
---
A
G
V
----
P
V
T
-----------
N
-
L
--
K
N
K
I
L
L
--
L
S
E
A
V
E
D
Q
V
----------
F
--
P
-
L
L
D
----
E
S
-
L
R
D
Y
L
T
L
R
F
Q
S
Y
M
T
HP
V
--
Y
-
T
R
Y
T
--
P
--
R
L
I
H
G
D
L
S
P
D
H
F
L
T
N
L
N
S
R
Q
T
P
L
T
G
I
I
D
F
G
D
A
A
I
S
-
D
P
D
Y
D
Y
V
Y
L
L
E
-------------
D
C
----------------
G
---------------------
E
---------
L
F
T
R
Q
-
V
M
A
Y
--
R
--
G
E
---
V
D
-
L
D
T
H
I
R
K
---------
V
S
L
F
V
T
F
-
D
Q
V
S
Y
--
L
L
------
E
G
L
R
A
R
D
Q
----------------------------------------------------
44
HHSearch
70.40
16%
-15
- C- -
-
3N4U
-
?
A:
[12-286]
------------------------------------------------
A
--
I
E
Q
L
Y
---
P
D
F
T
--
I
-
N
T
I
E
I
S
G
------
E
G
N
D
C
I
A
-
Y
E
I
----
N
------------
R
D
----
F
I
F
K
F
P
K
-
H
S
-
R
G
-
S
-
T
N
L
F
N
E
-
V
N
I
L
-
K
R
I
H
-----
N
K
--
L
P
L
P
I
P
E
V
V
F
T
---
G
M
-
P
S
ET-------
Y
Q
M
S
F
A
G
F
T
K
I
K
G
------
V
P
L
T
---
P
-
L
-
L
L
N
N
L
P
-----
K
Q
S
Q
N
-
Q
A
A
K
D
L
A
R
F
L
S
E
-
L
H
S
I
N
I
S
G
--
F
K
-
S
-----
N
----
L
V
L
-----------
D
-
F
--
R
E
K
I
N
E
--
D
N
K
K
I
K
K
L
L
----------
S
R
---
E
L
K
----
G
P
-
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
--
N
EI
Y
-
F
K
Y
Y
--
P
--
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
K
--
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
-
D
P
D
N
D
F
I
S
L
M
E
-------------
D
D
--
E
-----
E
-
Y
-----
G
---------------------
M
--------
E
F
V
S
K
I
-
L
N
H
Y
--
K
--
H
K
---
D
I
--
P
T
V
L
E
K
---------
Y
R
M
K
E
K
Y
-
W
S
F
E
K
--
I
I
------
Y
G
K
E
Y
G
Y
M
D
---------------------------------------------------
32
Fugue
70.38
12%
-38
- C3 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
-------
T
L
-
P
A
V
I
S
R
W
L
S
S
V
L
P
G
G
A
A
P
E
V
T
V
E
S
G
V
D
S
T
G
M
S
S
-
E
T
I
I
L
--
T
A
R
W
Q
---
Q
-------------------------
D
G
-
R
S
I
----
Q
------------
Q
K
----
L
V
A
R
V
A
P
-
A
A
-
E
--
D
-
V
P
V
F
P
T
Y
R
L
D
H
-
Q
F
E
V
I
R
L
V
G
E
L
--
T
D
V
P
V
P
R
V
R
W
I
ETT
G
D
-
V
----------
L
G
T
P
F
F
L
M
D
Y
V
E
G
V
V
PPDV
M
P
Y
T
FGD
N
-
W
-
F
-
A
D
A
P
-----
A
E
R
Q
R
-
Q
L
Q
D
A
T
V
A
A
L
A
T
-
L
H
S
I
P
N
A
Q
N
T
F
S
-
F
LT-
D
-
T
----
T
L
H
-----------
R
-
H
--
F
N
W
V
R
S
--
W
Y
D
F
A
V
E
G
I
----------
G
R
-
S
-
P
L
L
----
E
R
-
T
F
E
W
L
Q
S
H
W
P
D
D
A
A
--
A
--
R
-
E
P
-------
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
F
----
Q
P
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
W
M
I
F
A
-------------
H
R
--
V
-----
F
-
Q
-----
E
---------------------
L
--------
A
G
L
A
T
L
-
P
G
L
P
--
E
--
V
M
R
E
D
D
V
R
A
T
Y
Q
A
L
T
G
V
E
L
G
DL
H
W
F
Y
V
Y
S
G
V
-
M
W
A
C
V
--
F
M
------
R
T
G
A
R
R
V
H
F
G
E
I
E
K
P
D
D
V
E
S
LFYH
A
G
L
M
K
H
L
L
G
E
E
H
------------------------
41
Fugue
69.24
15%
-7
- C3 -
-
3CSV
11
?
A:
[4-333]
------------
S
R
E
D
E
I
R
D
F
L
A
T
H
G
Y
A
D
------------------------------
W
N
-
R
--
T
-
P
R
Y
Q
R
L
R
------
S
P
-
T
G
A
K
-
A
V
L
M
---
D
------------
W
-----------
S
-
P
E
----------
E
G
-
G
D
T
Q
-
P
F
V
D
L
A
Q
Y
L
R
N
--
L
D
I
S
A
P
E
I
Y
A
E
---
E
H
-
A
----------
R
G
--
L
L
L
I
E
D
L
G
D
------
A
L
F
T
---
E
-
V
-
I
-
N
N
-------
D
P
A
Q
E
M
P
L
Y
R
A
A
V
D
L
L
I
H
-
L
H
D
A
Q
T
P
E
L
A
R
L
-
D
---
P
-
E
----
T
L
S
-----------
E
M
T
--
R
L
A
F
S
E
--
Y
R
Y
A
I
L
----------------
G
-
D
A
A
----
E
D
-
N
R
K
R
F
E
H
R
F
A
Q
I
L
S
--
A
--
Q
-
L
E
-
G
--
D
M-
V
F
V
H
R
D
F
H
A
Q
N
L
L
W
L
P
E
R
E
G
L
A
R
V
G
V
I
D
F
Q
D
A
K
L
G
H
-
R
A
Y
D
L
V
S
L
L
Q
-------------
D
A
--
R
-----
R
-
D
-----
V
---------------------
P
--------
A
Q
V
E
A
Q
M
I
D
H
Y
--
I
--
Q
A
T
G
V
D
E
S
H
F
R
S
A
Y
A
---------
V
I
A
V
Q
R
N
M
R
I
L
G
I
--
F
A
------
R
L
S
Q
R
F
G
K
R
H
Y
I
E
F
V
P
R
V
W
A
-----
H
F
E
R
G
L
A
H
P
A
L
ASA
A
E
E
I
L
N
A
L
PAPA
P
E
V
L
E
R
L
R
A
28
Fugue
68.94
14%
-52
- C3 -
-
3HAM
3
?
A:
[1-299]
--------------
M
V
N
L
D
A
E
I
Y
E
H
L
N
K
Q
I
-
K
I
N
E
L
R
Y
L
S
S
G
D
-
D
S
D
T
F
--
L
C
N
E
------------
Q
Y
V
V
K
V
P
------
K
R
-
D
S
V
R
-
I
S
Q
----
K
------------
R
E
----
F
E
L
Y
R
F
L
-
E
N
---------------------------
C
K
--
L
S
Y
Q
I
P
A
V
V
Y
Q
---
S
D
-------------
R
F
N
I
M
K
Y
I
K
G
E
R
------
I
T
Y
E
---
Q
-
Y
---
H
K
L
S
-----
E
K
E
K
D
-
A
L
A
Y
D
E
A
T
F
L
K
E
-
L
H
S
I
E
I
D
C
S
V
S
L
-
F
---
S
-
D
A---
L
V
N
-----------
K
-
K
--
D
K
F
L
Q
D
--
K
K
L
L
I
S
I
L
E
----------
K
E
-
Q
-
L
L
T
----
D
E
-
M
L
E
H
I
E
T
I
Y
E
N
I
L
N
--
N
--
A
-
V
L
F
K
Y
T
P
--
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
N
N
----
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
L
L
D
C
-------------
S
T
--
D
-----
D
-
F
-----
G
---------------------
K
--------
E
F
G
R
K
V
-
L
K
Y
Y
--
Q
--
H
K
A
P
E
V
A
E
R
K
A
E
L
N
D
---------
V
Y
----------
W
--
S
I
------
D
Q
I
I
Y
G
Y
E
R
K
D
R
E
M
L
I
K
G
V
S
-----
E
L
L
Q
T
Q
A
E
M
F
I
F-----------------------
47
HHSearch
68.38
17%
-29
- C3 -
-
5UXD
2
?
A:
[8-251]
--------------------------------------------
D
A
L
L
D
--
L
A
A
R
H
---
G
L
-
D
LD
G
-
G
T
L
R
T
E
E
------
I
G
L
D
F
R
V
-
A
F
A
R
A
HD
G
------------
G
D
----
W
V
L
R
L
P
R
-
R
P
-
D
--
V
L
E
R
A
A
V
E
-
G
R
L
L
-
A
M
L
A
-----
P
H
--
L
D
V
A
V
P
D
W
R
I
S
---
T
---------------
S
E
L
I
A
Y
P
L
L
P
G
------
S
P
G
L
---
T
-
V
-
A
-
A
D
G
E
V
S
W
HV
D
M
A
S
T
-
V
Y
A
R
S
L
G
S
V
V
A
Q
-
L
H
A
V
D
A
E
A
--
A
A
-
A
---
T
-
G
I
E
V
R
S
P
A
-----------
Q
-
V
--
R
G
A
W
R
Q
--
D
L
A
R
V
G
A
E
--------------
F
-
E
I
A
----
P
A
-
L
R
E
R
W
E
A
W
L
A
D
D
G
------
C
-
W
P
G
H
--
S
--
V
L
T
H
G
E
L
Y
P
A
H
T
L
V
E
D
E
R
----
I
T
A
V
L
D
W
T
T
A
A
V
G
-
D
P
A
K
D
L
M
F
H
Q
V
-------------
S
A
----------------
P
---------------------
S
--------
A
I
F
E
V
A
-
L
Q
A
Y
--
A
--
E
G
---------------------------------------------------------------------------------------------------------
50
HHSearch
68.30
14%
-5
- C3 -
-
5IQC
2
AACA_STAAU
A:
[27-289]
--------------------------------------------------------------
K
--
V
-
D
S
I
E
I
I
G
------
S
G
Y
D
S
V
A
-
Y
L
V
----
N
------------
N
E
----
Y
I
F
K
T
K
F
-
S
T
-
N
K-
K
-
K
G
Y
A
K
E
-
K
A
I
Y
-
N
F
L
N
-----
T
N
LE
T
N
V
K
I
P
N
I
E
Y
S
---
Y
I
-
S
----------
D
E
L
S
I
L
G
Y
K
E
I
K
G
------
T
F
L
T
---
P
E
I
-
Y
-
S
T
M
S
-----
E
E
E
Q
N
-
L
L
K
R
D
I
A
S
F
L
R
Q
-
M
H
G
L
D
Y
T
D
--
I
S
-
E
---
C
------
T
I
D
-----------
N
-
K
--
Q
N
V
L
E
E
--
Y
I
L
-
L
R
E
T
I
----------
Y
--
N
-
D
L
T
----
D
I
-
E
K
D
Y
I
E
S
F
M
E
R
L
N
A
T-
T
--
V
-
F
E
G
K
--
K
--
C
L
C
H
N
D
F
S
C
N
H
L
L
L
D
G
N
N
---
R
L
T
G
I
I
D
F
G
D
S
G
I
I
-
D
E
Y
C
D
F
I
Y
L
L
E
-------------
D
S
--
E
-----
E
E
I
-----
G
---------------------
T
--------
N
F
G
E
D
I
-
L
R
M
Y
--
G
--
N
I
-----
D
I
E
K
A
K
E
Y
---------
Q
D
I
V
E
E
Y
-
Y
P
I
E
T
--
I
V
------
Y
G
I
K
N
I
K
Q
E
---------------------------------------------------
49
HHSearch
67.87
13%
3
- C3 -
-
1ZYL
-
SRKA_ECOLI
A:
[14-288]
--------------------------------------------
D
T
I
M
D
--
A
L
F
E
H
---
G
I
-
R
--
V
D
S
G
L
T
P
L
N
------
S
Y
-
E
N
R
V
-
Y
Q
F
Q
D
ED
R
------------
R
R
----
F
V
V
K
F
Y
R
-
P
E
-
R
WT
A
-
D
Q
I
L
E
E
-
H
Q
F
A
-
L
Q
L
V
-----
N
D
---
E
V
P
V
A
A
P
V
A
F
---
N
G
-
Q
T
L
L
N
H
-----
Q
G
F
Y
F
A
V
F
P
S
V
G
G
------
R
Q
F
E
---
A
-
D
---------------
N
I
-
D
Q
M
E
A
V
G
R
Y
L
G
R
-
M
H
Q
T
G
R
K
Q
L
F
I
H
-
R
P--
T
-
I
----
G
L
N
-----------
E
-
Y
--
L
I
E
P
R
K
--
L
F
E
D
A
-
T
L
I
----------
P
--
S
-
G
L
K
----
A
A
-
F
L
K
A
T
D
E
L
I
A
A
V
T
A
--
H
--
W
R
E
D
F
T
--
V
--
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
------
G
P
M
F
V
D
L
D
D
A
R
N
G
-
P
A
V
Q
D
L
W
M
L
L
N
-------------
G
D
--
K
-----
A
-
E
-----
Q
---------------------
R
--------
M
Q
L
E
T
I
-
I
E
A
Y
--
E
--
E
F
---
S
E
F
D
T
A
E
I
G
L
---------
I
E
P
L
R
A
M
-
R
L
V
Y
Y
--
L
A
------
W
L
M
R
R
W
A
D
P
---------------------------------------------------
51
HHSearch
67.02
14%
-6
- C3 -
-
5IQI
1
AACA_STAAU
C:
[27-289]
--------------------------------------------------------------
K
--
V
-
D
S
I
E
I
I
G
------
S
G
Y
D
S
V
A
-
Y
L
V
----
N
------------
N
E
----
Y
I
F
K
T
K
F
-
S
T
-
N
K-
K
-
K
G
F
A
K
E
-
K
A
I
Y
-
N
F
L
N
-----
T
N
LE
T
N
V
K
I
P
N
I
E
Y
S
---
Y
I
-
S
----------
D
E
L
S
I
L
G
Y
K
E
I
K
G
------
T
F
L
T
---
P
E
I
-
Y
-
S
T
M
S
-----
E
E
E
Q
N
-
L
L
K
R
D
I
A
S
F
L
R
Q
-
M
H
G
L
D
Y
T
D
--
I
S
-
E
---
C
------
T
I
D
-----------
N
-
K
--
Q
N
V
L
E
E
--
Y
I
L
L
R
E
-
T
I
----------
Y
--
N
-
D
L
T
----
D
I
-
E
K
D
Y
I
E
S
F
M
E
R
L
N
A
T-
T
--
V
-
F
E
G
K
--
K
--
C
L
C
H
N
D
F
S
C
N
H
L
L
L
D
G
N
N
---
R
L
T
G
I
I
D
F
G
D
S
G
I
I
-
D
E
Y
C
D
F
I
Y
L
L
E
-------------
D
S
--
E
-----
E
E
I
-----
G
---------------------
T
--------
N
F
G
E
D
I
-
L
R
M
Y
--
G
--
N
I
-----
D
I
E
K
A
K
E
Y
---------
Q
D
I
V
E
E
Y
-
Y
P
I
E
T
--
I
V
------
Y
G
I
K
N
I
K
Q
E
---------------------------------------------------
65
SP3
65.17
9%
-72
- C3 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
--------
A
-
K
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
------------------------
T
E
---
G
M
-
S
--
P
-
A
K
V
Y
K
L
V
------
G
E
-------------
N
------------
E
N
----
L
Y
L
K
M
T
D
-
S
R
-
Y
--
K
-
G
T
T
Y
D
V
-
E
R
E
K
-
D
M
M
L
W
L
E
G
K
------
L
P
V
P
K
V
L
H
F
---
E
R
-
H
----------
D
G
W
S
N
L
L
M
S
E
A
D
G
------
V
L
C
S
---
E
-
E
-
Y
---
E
D
-----
E
Q
S
P
E
-
K
I
I
E
L
Y
A
E
C
I
R
L
-
F
H
S
I
D
I
S
D
C
P
Y
------
T
-
N
----
S
L
D
-----------
S
-
R
--
L
A
E
L
D
Y
--
L
L
N
N
D
L
A
D
V
----------
D
C
-
E
-
N
W
E
----
E
D
T
P
F
K
D
P
R
E
L
Y
D
F
L
K
T
--
E
--
K
-
P
E
E
E
--
L
--
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
----
D
G
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
-
K
W
Y
D
I
A
F
C
V
R
-------------
S
I
R
E
D
-----
I
-
G
-----
E
---------------------
E
--------
Q
Y
V
E
L
F
-
F
D
L
L
--
G
--
I
K
P
D
--
W
E
K
I
K
Y
Y
I
L
---------
L
D
E
L
F
------------------------------------------------------------------------------