@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S3CRC1_GLAL2: (2019-02-02 )
MNQIVEDAGSLDVFRWPSSSPPSPENLEHAARLCQGALGSTSVAVVATPYNHAGWSAQDCIKVSFPSENRSFIAKVPRLVDENSATACKNEAQRASWASQHQIGPAVIAIDDLSGAFAMEFLSGQTLSAQMMLQDHLKTCTIGLLRRIHDAPSQHYMQIYNAPAAVKRMLQAADKERLLDGDDGLLLESLITWTFQKVGCQPTFQTLVPCHNDFHSQNIMLDQQGTLWAIDFEDCDLGDPMWDLGYLTANMGLEPLDLAGIYGCNMEQKKRLEVFYYLAIGHCAVWSAIHGPLWTQHYRDCMLRLRRGWLRL
Atome Classification :
(20 SA)
-----------.........10......--..20........30.......--.40.-----.----......50......---..60.-...---.-------.--------.-------.---70........80...-.....90........100...--.....110-------.--------.---.----.-----....120--....-....130-.----.---------------......140.......--150....-----.---.-------.160-..-----------.....-.170..----.----.----------.---------.---.180-----..---..-....190---------.....------------..-200-.-........210.......220-...------.....230---.......----240.......250-----------..------------------.-------------------------..--.-..-260-------------..------....---------------.-----------.-.----270....-...280.---......290.--.-----.---..----------..300.......310-------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------M
N
Q
I
V
E
DAGSL
D
V
F
RWP--SSSPPS
P
E
N
L
E
H
A
A
R
L
C
Q
GAL--GS
T
S
-----
V
----
A
V
V
ATPYNHAGW
S
A
---
Q
D
C
I
K
-
V
SF---P-------S--------E-------
N
---
R
S
F
I
A
K
V
P
R
L
VDENS-A
T
A
C
K
N
E
A
Q
R
ASWASQ-HQIG--
P
A
V
I
A
I
D--------D--------L---S----
G
-----
A
F
A
M
E
F
---LSGQ-
T
L
S
A
Q
M
--
M
----
L
---------------
Q
D
H
L
K
T
C
T
I
G
L
L
R
R
I
H--DA
P
S
Q
H
Y
-----
M
---
Q
-------
I
YN--A
P
-----------
A
A
V
K
R
-
M
L
Q
A
A
D
----
K
----
E
----------R---------L---LDG------D
D
---
G
L
-
L
L
E
S
L
I
T
---------
W
T
F
Q
K------------VG-C---Q-
P
T
F
Q
T
L
VPCHNDFHSQ
N
I
M
L--DQQ------G
T
L
W
A
I
DF---EDCDLGD----P
M
W
D
L
G
Y
L
T
ANM------------GL------------------E-------------------------PL--D-LA-G---------------IY------GC
N
M
---------------
E
-----------
Q
-
K
----
K
R
L
E
V
F
Y
-
Y
L
A
I
G
H
C
---
A
V
W
S
A
IHG
P
L
--
W
-----
T
---
Q
H
----------
Y
R
D
C
M
L
R
L
R
R
GWLRL-------------------------------------------
55
HHSearch
81.75
18%
-25
- C1 -
-
1NW1
-
CKA2_CAEEL
A:
[50-415]
------------------------------------
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
--
G
G
A
W
KTVPL
E
----
H
L
R
I
S
R
I
K
-
G
G
M
S
----
N
M
L
F
L
-
C
R
L
---
S
-------
E
VYPPIRN-
E
-------
P
---
N
K
V
L
L
R
V
Y
F
N
P
E
T
E
S
---
H
L
V
A
E
S
V
I
F
T
L
L
S
E
-
R
H
L
G
--
P
K
L
Y
G
I
F
--------
S
-----------------
G
-----
G
R
L
E
E
Y
---
I
P
S
R
-
P
L
S
C
H
E
--
I
----
S
---------------
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
--
Q
L
E
V
P
I
W
-----
K
EPD
Y
-------
L
C
E
--
A
L
-----------
Q
R
W
L
K
-
Q
L
T
G
T
V
----
D
----
A
E
H
R
F
------
D
---------
L
---
P
E
E
CGVSSV
N
C
---
L
D
-
L
A
R
E
L
E
F
---------
L
R
A
H
I
------------
S
--------
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
--
P
K
--------
R
L
V
L
I
D
F
---
E
Y
A
S
Y
N
Y
----
R
A
F
D
F
A
N
H
F
I
E
W
------------
T
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
-------------------------
N
D
Q
M
L
E
F
F
-
L
---------------
N
Y
L
-----
R
E
Q
G
---------------
N
TRENE
L
Y
K
K
S
E
D
L
V
----
Q
E
T
L
P
F
V
-
P
V
S
H
F
F
W
---
G
V
W
G
L
L
Q
V
E
L
--
S
-----
P
VGF
G
F
----------
A
D
Y
G
R
D
R
L
S
L
Y
-----------------------------------------------
56
HHSearch
81.43
18%
-25
- C1 -
-
1NW1
-
CKA2_CAEEL
B:
[50-415]
------------------------------------
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
--
G
G
A
W
KTVPL
E
----
H
L
R
I
S
R
I
K
-
G
G
M
S
----
N
M
L
F
L
-
C
R
L
---
S
-------
E
VYPPIRN-
E
-------
P
---
N
K
V
L
L
R
V
Y
F
N
P
E
T
E
S
---
H
L
V
A
E
S
V
I
F
T
L
L
S
E
-
R
H
L
G
--
P
K
L
Y
G
I
F
--------
S
-----------------
G
-----
G
R
L
E
E
Y
---
I
P
S
R
-
P
L
S
C
H
E
--
I
----
S
---------------
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
--
Q
L
E
V
P
I
W
-----
K
EPD
Y
-------
L
C
E
--
A
L
-----------
Q
R
W
L
K
-
Q
L
T
G
T
V
----
D
----
A
E
H
R
F
------
D
---------
L
---
P
E
E
CGVSSV
N
C
---
L
D
-
L
A
R
E
L
E
F
---------
L
R
A
H
I
------------
S
--------
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
--
P
K
--------
R
L
V
L
I
D
F
---
E
Y
A
S
Y
N
Y
----
R
A
F
D
F
A
N
H
F
I
E
W
------------
T
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
-------------------------
N
D
Q
M
L
E
F
F
-
L
---------------
N
Y
L
-----
R
E
Q
G
---------------
N
TRENE
L
Y
K
K
S
E
D
L
V
----
Q
E
T
L
P
F
V
-
P
V
S
H
F
F
W
---
G
V
W
G
L
L
Q
V
E
L
--
S
-----
P
VGF
G
F
----------
A
D
Y
G
R
D
R
L
S
L
Y
-----------------------------------------------
62
HHSearch
80.70
15%
-22
- C1 -
-
3C5I
3
?
D:
[11-354]
------------------------------------
L
T
D
P
L
Y
I
K
K
I
C
L
E
K
V
--
P
E
W
N
HFTE-
D
----
N
L
R
V
K
Q
I
L
---
L
T
----
N
Q
L
F
E
-
V
G
L
---
K
-------
E
E
T
A
N
N
Y
NS
I
-------
R
---
T
R
V
L
F
R
I
Y
G
K
H
V
D
E
L
-
Y
-
N
T
I
S
E
F
E
V
Y
K
T
M
S
K
-
Y
K
I
A
--
P
Q
L
L
N
T
F
--------
N
-----------------
G
-----
G
R
I
E
E
W
---
L
Y
G
D
-
P
L
R
I
D
D
--
L
----
K
---------------
N
P
T
I
L
I
G
I
A
N
V
L
G
K
F
H
--
T
L
S
R
K
R
H
LPEH-
W
---
D
RTP
C
---
I
F
K
--
M
M
-----------
E
K
W
K
N
-
Q
L
F
K
Y
K
----
N
----
I
----------
E
---------
K
---
Y
N
C
------
D
I
---
H
K
-
Y
I
K
E
S
D
K
---------
F
I
K
F
M
------------
K
V
-
Y
S
KS
D
-
N
L
A
N
T
I
V
F
C
H
N
D
L
Q
E
N
N
I
I
N
--
T
N
-------
K
C
L
R
L
I
D
F
---
E
Y
S
G
F
N
F
----
L
A
T
D
I
A
N
F
F
I
E
T
------------
S
I
DYSVSSYPF
F
E
I
D
KKKYI
S
-------------------------
Y
E
N
R
K
L
F
I
-
T
---------------
A
Y
L
-----
S
N
Y
L
DKVVPT
P
K
L
I
-----
D
-----------
E
I
L
----
E
A
V
E
V
Q
A
-
L
G
A
H
L
L
W
---
G
F
W
S
I
I
R
G
Y
Q
--
T
KSYNE
F
---
D
F
----------
F
L
Y
A
E
Q
R
L
K
M
Y
D
D
---------------------------------------------
59
HHSearch
78.91
16%
-23
- C1 -
-
5FTG
11
CHKA_HUMAN
A:
[4-352]
----------------------------------
P
E
P
R
T
R
R
R
A
Y
L
W
C
K
E
F
L
--
P
G
A
W
RGLRE
D
----
E
F
H
I
S
V
I
R
-
G
G
L
S
----
N
M
L
F
Q
-
C
S
L
---
P
-------
D
--------
T
TATLGDE
P
---
R
K
V
L
L
R
L
Y
G
--------
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
-
R
S
L
G
--
P
K
L
Y
G
I
F
--------
P
-----------------
Q
-----
G
R
L
E
Q
F
---
I
P
S
R
-
R
L
D
T
E
E
--
L
----
S
---------------
L
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
--
G
M
K
M
P
F
N
-----
K
---
E
PKW----
L
F
G
--
T
M
-----------
E
K
Y
L
K
-
E
V
L
R
I
K
----
F
----
T
----------
E
E
S
R
------
I
K
K
-
L
H
K
------
L
L
---
S
Y
N
L
P
L
E
L
E
N
---------
L
R
S
L
L
------------
E
--------
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
--
L
E
G
RENSEK
Q
K
L
M
L
I
D
F
---
E
Y
S
S
Y
N
Y
----
R
G
F
D
I
G
N
H
F
C
E
W
------------
M
Y
------------------
D
YSYEKYPF
F
R
A
N
IRKYPT-------
K
K
Q
Q
L
H
F
I
-
S
---------------
S
Y
L
-----
P
A
F
Q
NDFENLS
T
E
E
K
S
I
I
K
E
-----------
E
M
L
----
L
E
V
N
R
F
A
-
L
A
S
H
F
L
W
---
G
L
W
S
I
V
Q
A
K
I
--
S
-------------------------------------------------------------------------------
60
HHSearch
78.64
16%
-0
- C1 -
-
5FUT
10
CHKA_HUMAN
A:
[4-352]
----------------------------------
P
E
P
R
T
R
R
R
A
Y
L
W
C
K
E
F
L
--
P
G
A
W
RGLRE
D
----
E
F
H
I
S
V
I
R
-
G
G
L
S
----
N
M
L
F
Q
-
C
S
L
---
P
-------
D
--------
T
TATLGDE
P
---
R
K
V
L
L
R
L
Y
G
------G
A
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
-
R
S
L
G
--
P
K
L
Y
G
I
F
--------
P
-----------------
Q
-----
G
R
L
E
Q
F
---
I
P
S
R
-
R
L
D
T
E
E
--
L
----
S
---------------
L
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
--
G
M
K
M
P
F
N
-----
K
---
E
PKW----
L
F
G
--
T
M
-----------
E
K
Y
L
K
-
E
V
L
R
I
K
----
F
----
T
----------
E
E
S
R
------
I
K
K
-
L
H
K
------
L
L
---
S
Y
N
L
P
L
E
L
E
N
---------
L
R
S
L
L
------------
E
--------
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
--
L
E
G
RENSEK
Q
K
L
M
L
I
D
F
---
E
Y
S
S
Y
N
Y
----
R
G
F
D
I
G
N
H
F
C
E
W
------------
M
Y
------------------
D
YSYEKYPF
F
R
A
N
IRKYPT-------
K
K
Q
Q
L
H
F
I
-
S
---------------
S
Y
L
-----
P
A
F
Q
NDFENLS
T
E
E
K
S
I
I
K
E
-----------
E
M
L
----
L
E
V
N
R
F
A
-
L
A
S
H
F
L
W
---
G
L
W
S
I
V
Q
A
K
I
--
S
-------------------------------------------------------------------------------
26
Fugue
75.30
13%
4
- C1 -
-
2QG7
-
?
A:
[50-458]
YPITESNLRIL
E
G
E
D
R
S
E
K
A
K
E
L
L
K
K
Y
V
--
S
N
V
F
E
N
E
K
T
L
Y
I
Y
C
K
Y
V
M
L
H
Y
GK
D
L
V
N
-----
P
----
N
E
V
D
S
L
E
F
Q
I
I
N
G
T
---
N
I
L
I
K
-
V
K
D
---
M
-------
S
--------
K
-------
Q
---
A
K
Y
L
I
R
L
Y
G
--
P
T
D
E
-
I
I
N
R
E
R
E
K
K
I
S
C
I
L
Y
N
-
K
N
I
A
--
K
K
I
Y
V
F
------------------
F
---
T
----
N
-----
G
R
I
E
E
F
---
M
D
G
Y
-
A
L
S
R
E
D
--
I
----
K
---------------
N
P
K
F
Q
K
L
I
A
K
N
L
K
L
L
H
D
I
K
L
N
E
N
L
Y
-----
K
---
E
-------
L
Q
V
--
T
Q
KVPGTRPSF
L
W
N
T
I
W
K
-
Y
F
H
L
L
N
----
E
----
E
----------
R
K
KICSFDAK
A
---
N
I
L
------
K
L
---
I
D
-
F
D
V
L
R
D
S
---------
I
V
E
V
E
------------
S
L
-
C
---
K
-
R
E
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
T
V
G
E
G
------
D
S
I
S
F
I
D
F
---
E
Y
S
C
P
M
E
----
R
A
Y
D
I
A
N
H
F
N
E
Y
AGFNCDWDLTPS
K
E
------------------
E
-------------------------
E
Y
--
H
-
F
I
-
M
---------------
H
Y
L
GTDD
E
E
L
I
N
---------------
Q
-----------
L
-
I
----
R
E
I
Q
P
F
Y
-
I
C
S
H
I
N
W
---
G
L
W
S
L
L
Q
G
M
H
--
S
-----
F
---
D
F
----------
I
N
Y
G
M
T
R
L
T
A
S
C
L
P
I
F
R
S
K
V--------------------------------------
27
Fugue
75.27
15%
-5
- C1 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
----------------
G
M
K
E
L
L
S
T
M
D
L
D
--
T
D
A
N
T
I
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
--
G
G
A
W
-----
K
----
T
V
P
L
E
H
L
R
I
S
R
I
K
G
G
MS
N
M
L
F
L
-
C
R
L
S
EV
Y
-------
P
--------
P
-------
I
---
R
N
E
P
N
K
V
L
L
R
V
Y
F
N
P
-
E
T
E
S
H
L
V
A
E
S
V
I
F
T
L
L
-
S
E
R
H
--
L
G
P
K
L
Y
G
--------
I
--------
F
---
S
----
G
-----
G
R
L
E
E
Y
---
I
P
S
R
-
P
L
S
C
H
E
--
I
----
S
---------------
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
--
Q
L
E
V
P
I
W
-----
K
---
E
-------
P
D
Y
--
L
C
-----------
E
A
L
Q
R
-
W
L
K
Q
L
T
----
G
----
T
V
DAE
H
R
F
D
L
P
E
---------
E
---
C
G
V
------
S
S
---
V
N
-
C
L
D
L
A
R
E
---------
L
E
F
L
R
------------
A
H
-
I
---
S
-
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
--
P
K
R
--------
L
V
L
I
D
F
---
E
Y
A
S
Y
N
Y
----
R
A
F
D
F
A
N
H
F
I
E
W
------------
T
I
------------------
D
Y------------------------
D
I
--
D
-
E
A
-
P
---------------
F
Y
------
K
I
Q
T
---------------
E
-----------
N
-
F
----
P
E
N
D
Q
M
L
-
E
F
F
L
N
Y
L
---
R
E
Q
G
N
T
R
E
N
E
--
L
-----
Y
---
K
K
----------
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
ELSPVGFG
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA
41
SP3
72.95
14%
-15
- C1 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-------------
G
M
K
E
L
L
S
T
M
D
L
D
T
D
A
--
N
T
I
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
G
A
--
W
K
T
V
-----
P
----
L
E
H
L
R
I
S
R
I
K
G
G
M
S
---
N
M
L
F
L
-
C
R
L
---
S
EVYPPIR
N
--------
E
-------
P
---
N
K
V
L
L
R
V
Y
F
N
P
E
T
---
E
S
H
L
V
A
E
S
V
I
F
T
L
L
S
E
-
R
H
L
G
--
P
K
L
Y
G
I
------------------
F
---
S
----
G
-----
G
R
L
E
E
Y
---
I
P
S
R
-
P
L
S
C
H
E
--
I
----
S
---------------
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
--
Q
L
E
V
P
I
W
-----
K
---
E
-------
P
D
Y
--
L
C
-----------
E
A
L
Q
R
-
W
L
K
Q
L
T
----
G
----
T
V
DAE
H
R
F
D
L
-
P
---------
E
---
E
C
G
------
V
S
---
S
V
-
N
C
L
D
L
A
R
---------
E
L
E
F
L
------------
R
A
-
H
I
--
S
-
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
--
P
--------
K
R
L
V
L
I
D
F
---
E
Y
A
S
Y
N
Y
----
R
A
F
D
F
A
N
H
F
I
E
W
------------
T
I
------------------
D
YDIDEAPF
Y
K
I
Q
TENFPE
N
D
Q
M
L
E
F
F
L
--
N
-
Y
L
-
R
---------------
E
Q
------
G
N
T
R
---------------
E
-----------
N
-
E
----
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
---
V
P
V
S
H
F
F
W
G
V
--
W
-----
G
---
L
L
Q
V
ELSPVGFG
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA-----------------------------------
39
Fugue
72.70
20%
-25
- C1 -
-
4WW7
1
BUD32_YEAST
A:
[4-257]
----------E
F
I
D
K
V
S
S
Y
L
T
P
D
V
D
I
A
P
--
I
S
Q
G
A
A
-------------------
I
V
-----
F
----
T
T
T
T
H
P
Y
L
P
R
A
------------------
K
-------
D
--------
S
-------
H
---
Q
K
Y
I
I
K
Y
-
R
P
R
T
L
N
E
-
S
R
L
L
A
K
L
Y
L
I
P
G
L
C
V
--------
P
Q
L
I
A
C
D
--------
P
--------
Y
---
N
----
G
-----
F
I
W
L
E
F
---
L
-
G
E
-
D
L
P
G
G
H
--
G
----
F
---------------
S
N
------------------------------------------------------------
L
K
N
-
F
L
W
M
H
D
----
Q
----
D
-----------------------------------------
P
Y
S
D
L
V
A
---------
T
T
L
R
K
------------
V
G
-
R
---
Q
I
G
L
L
H
W
N
D
Y
C
H
G
D
L
T
S
S
N
I
V
L
--
V
R
D
------
G
A
R
W
T
P
H
L
---
I
D
F
G
L
G
--------
S
V
S
N
L
V
E
D
K
------------
G
V
------------------
D
-------------------------
L
Y
--
V
-
L
E
R
A
---------------
I
L
------
S
T
H
S
---------------
K
-----------
H
-
A
----
E
K
Y
N
A
W
I
-
M
E
G
F
E
E
V
---
Y
R
E
Q
G
A
K
G
A
K
--
K
-----
L
---
K
E
----------
V
T
K
R
F
E
E
V
R
L
R
G
R
K
R
-------------------------------------------
75
HHSearch
70.82
16%
-37
- C1 -
-
3I1A
4
?
B:
[6-290]
-------------------------------------
I
Q
A
Q
Q
L
I
E
L
L
K
V
H
Y
--
G
I
D
I
-----
H
----
T
A
--
Q
F
I
Q
-
G
G
A
D
----
T
N
A
F
A
-
Y
Q
A
---
D
-------
S
--------
E
-------
S
---
K
S
Y
F
I
K
L
K
Y
G
Y
H
D
-------
E
I
N
L
S
I
I
R
L
L
H
D
-
S
G
I
K
E
I
I
F
P
I
H
T
L
EAKL
F
Q
Q
L
K
--------
H
---
F
----
K
-----
I
I
A
Y
P
F
---
I
H
A
P
-
N
G
F
T
Q
N
-------
L
---------------
T
G
K
Q
W
K
Q
L
G
K
V
L
R
Q
I
H
--
E
T
S
V
P
I
S
-----
I
---
Q
Q
Q
LR---
K
E
I
--
Y
S
-----------
P
K
W
R
E
-
I
V
R
S
F
Y
NQIE
F
DNSD
D
----------
K
---------
L
T
A
A
F
K
S
------
F
F
N
Q
N
S
A
-
A
I
H
R
L
V
D
---------
T
S
E
K
L
------------
S
K
K
I
---
Q
-
P
D
L
D
K
Y
V
L
C
H
S
D
I
H
A
G
N
V
L
V
--
G
N
E
------
E
S
I
Y
I
I
D
W
---
D
E
P
M
L
A
P
----
K
E
R
D
L
M
F
I
G
G
G
V
------------
G
N
------------------
V
WNK----------------------
P
H
E
I
Q
Y
F
Y
-
E
---------------
G
Y
G-----
E
I
N
V
---------------
D
-------------
K
----
T
I
L
S
Y
Y
R
-
H
E
R
I
V
E
D
---
I
A
------------------------------------------------------------------------------------------
32
Fugue
70.79
12%
-14
- C1 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
-T
L
P
A
V
I
S
R
W
L
S
S
V
L
P
G
G
A
A
P
E
V
T
V
E
S
G
VD
S
T
G
M
S
S
E
T
I
I
L
T
A
R
W
Q
Q
D
G
R
S
--
I
Q
Q
K
-----
L
----
V
A
R
V
A
P
-----------
A
A
E
D
V
-
P
V
F
---
P
-------
T
--------
Y
-------
R
---
L
D
H
Q
F
E
V
I
R
L
V
G
E
L
T
-
D
V
P
V
P
R
V
R
W
I
E
T
--
T
G
-
D
V
L
G
--
T
P
F
F
L
M
D
--------
Y
--------
V
---
E
----
G
V
V
PPD
V
M
P
Y
T
F
---
G
D
N
W
-
F
A
D
A
P
A
--
E
----
R
---------------
Q
R
Q
L
Q
D
A
T
V
A
A
L
A
T
L
H
--
S
I
P
N
A
Q
N
T
----
F
---
S
-------
F
L
T
DT
T
L
-----------
H
R
H
F
N
-
W
V
R
S
W
Y
----
D
----
F
----------
A
---------
V
---
E
G
I
------
G
R
---
S
P
-
L
L
E
R
T
F
E
---------
W
L
Q
S
H
------------
W
P
-
D
---
D
-
A
A
A
R
E
P
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
--
R
D
F
------
Q
P
V
A
V
L
D
W
---
E
M
V
A
L
G
P
----
R
E
L
D
V
A
W
M
I
F
A
H
------------
R
V
------------------
F
-------------------------
Q
E
--
L
-
A
G
-
L
A
TLPGLPEVMR
E
D
D
V
R
A
------
T
Y
Q
A
---------------
L
-----------
T
-
G
----
V
E
L
G
D
L
H
-
W
F
Y
V
Y
S
G
---
V
M
W
A
C
V
F
M
R
T
--
G
-----
A
---
R
R
----------
V
H
F
G
E
I
E
K
P
D
D
V
E
S
L
FYH
A
G
L
M
K
H
L
L
G
EEH----------------------------
65
HHSearch
70.08
15%
-27
- C1 -
-
3MES
3
?
A:
[50-404]
--------------------------------------
D
T
E
I
I
I
G
I
C
R
K
N
I
--
P
G
W
K
-----
E
INES
Y
I
E
V
K
Q
I
F
-
S
G
L
T
----
N
Q
L
F
V
-
V
S
I
---
V
----------------
N
-------
E
LKH
P
R
I
L
F
R
I
Y
G
K
H
V
-
K
F
-
Y
-
D
S
K
V
E
L
D
V
F
R
Y
L
S
N
-
I
N
I
A
--
P
N
I
I
A
D
F
--------
P
-----------------
E
-----
G
R
I
E
E
F
---
I
D
G
E
-
P
L
T
T
K
Q
--
L
----
Q
---------------
L
T
H
I
C
V
E
V
A
K
N
M
G
S
L
H
--
I
I
N
S
K
R
A
DFPSR
F
---
D
KEPI---
L
F
K
--
R
I
-----------
Y
L
W
R
E
-
E
A
K
I
Q
V
----
S
----
K
NN------------------
I
---
D
K
E
------
L
Y
---
S
K
-
I
L
E
E
I
D
Q
---------
L
E
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
L
---
Y
-
S
P
A
F
S
L
V
F
A
H
N
D
L
Q
E
N
N
L
L
Q
--
T
Q
-------
N
N
I
R
M
I
D
Y
---
E
Y
S
A
I
N
F
----
A
G
A
D
I
A
N
Y
F
C
E
Y
------------
I
Y
------------------
D
YCSEKQPY
F
K
F
K
YEDYPC-------
E
E
L
R
K
L
F
I
-
S
---------------
V
Y
L
-----
S
Q
T
L
---------------
Q
EQVMPSQ
Q
I
V
H
I
M
T
----
K
A
V
E
V
F
T
-
L
I
S
H
I
T
W
---
G
L
W
S
I
A
----V-
E
-----
F
---
D
F
----------
T
E
Y
A
N
T
R
F
T
H
Y
L
Q
---------------------------------------------
64
HHSearch
69.46
15%
-33
- C1 -
-
3MES
2
?
B:
[50-404]
--------------------------------------
D
T
E
I
I
I
G
I
C
R
K
N
I
--
P
G
W
K
-----
E
INES
Y
I
E
V
K
Q
I
F
-
S
G
L
T
----
N
Q
L
F
V
-
V
S
I
---
V
----------------
N
-------
E
LKH
P
R
I
L
F
R
I
Y
G
K
H
V
--
F
-
Y
-
D
S
K
V
E
L
D
V
F
R
Y
L
S
N
-
I
N
I
A
--
P
N
I
I
A
D
F
--------
P
-----------------
E
-----
G
R
I
E
E
F
---
I
D
G
E
-
P
L
T
T
K
Q
--
L
----
Q
---------------
L
T
H
I
C
V
E
V
A
K
N
M
G
S
L
H
--
I
I
N
S
K
R
A
DFPSR
F
---
D
KEPI---
L
F
K
--
R
I
-----------
Y
L
W
R
E
-
E
A
K
I
Q
V
----
S
----
K
NN--------
Q
---------
I
---
D
K
E
------
L
Y
---
S
K
-
I
L
E
E
I
D
Q
---------
L
E
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
L
---
Y
-
S
P
A
F
S
L
V
F
A
H
N
D
L
Q
E
N
N
L
L
Q
--
T
Q
-------
N
N
I
R
M
I
D
Y
---
E
Y
S
A
I
N
F
----
A
G
A
D
I
A
N
Y
F
C
E
Y
------------
I
Y
------------------
D
YCSEKQPY
F
K
F
K
YEDYPC-------
E
E
L
R
K
L
F
I
-
S
---------------
V
Y
L
-----
S
Q
T
L
---------------
Q
EQVMPSQ
Q
I
V
H
I
M
T
----
K
A
V
E
V
F
T
-
L
I
S
H
I
T
W
---
G
L
W
S
I
A
----SV
E
-----
F
---
D
F
----------
T
E
Y
A
N
T
R
F
T
H
Y
L
Q
---------------------------------------------
51
HHSearch
69.34
14%
-25
- C1 -
-
4R78
2
?
A:
[18-297]
-----------------------------------
G
S
H
M
E
K
I
I
K
E
K
I
S
S
L
L
--
S
Q
E
E
-----
E
----
V
L
S
V
E
Q
L
--
G
G
M
T
----
N
Q
N
Y
L
-
A
K
T
--------------------
T
-------
N
---
K
Q
Y
I
V
K
F
F
G
K
G
T
E
K
L
-
I
-
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
-
L
G
L
D
--
V
K
N
Y
L
F
D
--------
I
--------
E
---
A
----
G
-----
I
K
V
N
E
Y
---
I
E
S
A
I
T
L
D
S
T
S
-----------------------
I
K
T
K
F
D
K
I
A
P
I
L
Q
T
I
H
--
T
S
A
K
E
L
R
G
E
---
F
---
A
-------
P
F
E
--
E
I
-----------
K
K
Y
E
S
-
L
I
E
E
Q
I
---------
P
----------
Y
---------------
A
------
N
Y
---
E
S
-
V
R
N
A
V
F
S
---------
L
E
K
R
L
------------
A
D
--------
L
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
--
S
P
Q
------
G
R
L
Y
L
I
D
W
---
E
Y
S
S
M
N
D
----
P
M
W
D
L
A
A
L
F
L
E
S
------------
E
F
------------------
T
-------------------------
S
Q
E
E
E
T
F
L
-
S
---------------
H
Y
E-----
S
D
Q
T
---------------
P
-----------
V
S
H
----
E
K
I
A
I
Y
K
-
I
L
Q
D
T
I
W
---
S
L
W
T
V
Y
K
E
E
Q
--
G
-----
E
---
D
F
----------
G
D
Y
G
V
N
R
Y
Q
R
A
V
----------------------------------------------
71
HHSearch
68.66
14%
-48
- C1 -
-
5IGH
-
?
A:
[8-295]
--------------------------------------
D
T
S
Q
L
Y
A
L
A
A
R
-
H
--
G
L
K
L
-----
H
-----
G
P
L
T
V
N
E
-
L
G
L
D
----
Y
R
I
V
I
-
A
T
V
---
D
----------------
D
-------
G
---
R
R
W
V
L
R
I
P
R
R
A
E
V
S
---
A
K
V
E
P
E
A
R
V
L
A
M
L
K
N
R
L
P
F
A
V-
P
D
W
R
V
A
N
--------
A
--------
E
L
V
A
Y
P
MLE
D
-----
S
T
A
M
V
I
---
Q
P
G
S
-
S
T
P
D
W
V
V
P
Q
----
D
---------------
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
H
--
A
V
P
I
S
A
A
-----
V
---
D
A
G
M
L
I
R
T
P
T
Q
--
A
R
-----------
Q
K
V
A
D
-
D
V
D
R
V
R
---------
R
----------
E
-----------------------
F
---
V
V
-
N
D
K
R
L
H
R
---------
W
Q
R
W
L
------------
D
D
-
D
---
S
-
S
W
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
--
D
N
T
E-----
R
V
S
G
M
I
D
W
---
S
E
A
R
V
D
D
----
P
A
I
D
M
A
A
H
L
M
V
F
------------
G
E
------------------
E
-------------------------
G
L
--
A
K
L
L
-
L
---------------
T
Y
E
-----
A
A
G
G
---------------
R
V
W
P--------
R
L
A
----
H
H
I
A
E
R
L
-
A
F
G
A
V
T
Y
---
A
L
F
A
L
D
S
G
N
-------------
E
E
----------
Y
L
A
A
A
K
A
---------------------------------------------------
72
HHSearch
68.01
16%
-18
- C1 -
-
3CSV
9
?
A:
[5-279]
--------------------------------------
R
E
D
E
I
R
D
F
L
A
T
-
H
--
G
Y
A
D
-----
W
----
N
R
--
T
P
-------------
R
Y
Q
R
L
R
S
---
P
----------------
T
-------
G
---
A
K
A
V
L
M
D
W
S
P
E
E
G
G
----
D
T
Q
P
F
V
D
L
A
Q
Y
L
R
N
-
L
D
I
S
A-
P
E
I
Y
A
E
E
--------
H
--------
A
---
R
----
G
-----
L
L
L
I
E
D
---
L
G
D
A
-
L
F
T
E
V
I
--
N
N
DPA
Q
---------------
E
M
P
L
Y
R
A
A
V
D
L
L
I
H
L
H
--
D
A
Q
T
P
E
L
AR---
L
---
D
-------
P
E
---
T
L
-----------
S
E
M
T
R
L
A
F
S
E
Y
R
---------
Y
----------
A
---------
I
---
L
G
D
------
A
A
---
E
D
-
N
R
K
R
F
E
H
---------
R
F
A
Q
I
------------
L
S
-
A
-----
Q
L
E
G
D
M
V
F
V
H
R
D
F
H
A
Q
N
L
L
W
--
L
P
E
REGL--
A
R
V
G
V
I
D
F
---
Q
D
A
K
L
G
H
----
R
A
Y
D
L
V
S
L
L
Q
D
A
------------
R
R
------------------
D
VP-----------------------
A
Q
V
E
A
Q
M
I
-
D
---------------
H
Y
I
-----
Q
A
T
G
---------------
V
D
E
S
--------
H
F
R
----
S
A
Y
A
V
I
A
-
V
Q
R
N
M
R
I
---
L
G
I
F
A
R
--------------------------------------------------------------------------------------
38
Fugue
67.80
19%
-30
* C2 *
-
4EO3
3
?
A:
[2-322]
-------------------
A
R
V
K
H
F
E
L
L
--
T
D
E
G
K
T
F
T
H
V
D
---------
L
--
Y
G
K
Y
-----
T
----
I
L
F
F
F
P
K
A
G
T
S
G
S
T
---
R
E
A
V
E
-
F
S
R
---
E
-------
N
--------
F
-------
E
---
K
A
Q
V
V
G
I
S
R
----
D
S
-
V
E
A
L
K
R
F
K
E
K
N
---------
D
--
L
K
V
T
L
L
S
--------
D
--------
P
---
E
----
G
-----
I
L
H
E
F
F
NVL
E
N
G
K
-
T
V
R
S
T
F
--
L
----
I
D
RWGFVR
K
E
W
R
RVKV
E
G
H
V
Q
E
V
K
E
A
L
D
R
L
I
E
--
E
D
L
S
L
---------------------
N
--
K
H
-----------
I
E
W
R
R
-
A
R
R
A
L
K
----
K
----
D
----------
R
---------
V
---
P
R
E
------
E
L
---
E
L
-
L
I
K
A
A
H
L
APSCMNNQP
W
R
F
V
V
------------
V
D
-
E
---
E
-
E
L
L
K
K
I
H
E
A
---
L
P
G
G
N
Y
W
M
--
K
N
A
------
P
A
L
I
A
V
H
S
K
KD
F
D
C
A
L
P
D
NRDY
F
L
F
D
T
G
L
A
V
G
N
L
L
V
Q
A
T
Q
M
-----
G
L
------------------
V
-------------------------
A
H
--
P
-
V
A
-
G
---------------
Y
D
------
P
V
K
V
---------------
K
-----------
E
-
I
L
KIP
E
D
H
V
L
I
T
-
L
I
A
V
G
Y
L
GDE
S
E
L
S
E
K
H
R
E
L
E
-
R
-----
S
---
E
R
----------
V
R
K
E
L
S
E
I
V
R
W
N
L
---------------------------------------------
70
HHSearch
67.70
14%
-46
- C1 -
-
5IGI
3
?
A:
[8-295]
--------------------------------------
D
T
S
Q
L
Y
A
L
A
A
R
-
H
--
G
L
K
L
-----
H
-----
G
P
L
T
V
N
E
-
L
G
L
D
----
Y
R
I
V
I
-
A
T
V
---
D
----------------
D
-------
G
---
R
R
W
V
L
R
I
P
R
R
A
E
V
S
---
A
K
V
E
P
E
A
R
V
L
A
M
L
K
N
R
L
P
F
A
V-
P
D
W
R
V
A
N
--------
A
--------
E
L
V
A
Y
PMLE
D
-----
S
T
A
-
V
I
---
Q
P
G
S
-
S
T
P
D
W
V
VP
Q
----
D
---------------
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
H
--
A
V
P
I
S
A
A
-----
V
---
D
A
GMLIRT
P
T
Q
--
A
R
-----------
Q
K
V
A
D
-
D
V
D
R
V
R
---------
R
----------
E
-----------------------
F
---
V
V
-
N
D
K
R
L
H
R
---------
W
Q
R
W
L
------------
D
D
-
D
---
S
-
S
W
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
--
D
N
T
E-----
R
V
S
G
M
I
D
W
---
S
E
A
R
V
D
D
----
P
A
I
D
M
A
A
H
L
M
V
F
------------
G
E
------------------
E
-------------------------
G
L
--
A
K
L
L
-
L
---------------
T
Y
E
-----
A
A
G
G
---------------
R
V
W
P--------
R
L
A
----
H
H
I
A
E
R
L
-
A
F
G
A
V
T
Y
---
A
L
F
A
L
D
S
G
N
-------------
E
E
----------
Y
L
A
A
A
K
A
---------------------------------------------------
69
HHSearch
66.77
13%
-63
- C1 -
-
2PPQ
-
KHSE_AGRFC
A:
[8-282]
--------------------------------------
T
E
D
E
L
R
N
F
L
-
T
Q
Y
--
D
V
G
S
-----
L
-----
T
S
Y
K
G
I
A
-
E
-------
N
S
N
F
L
-
L
H
T
--------------------
T
-------
K
---
D
P
L
I
L
T
L
Y
E
K
---
K
---
N
D
L
P
F
F
L
G
L
M
Q
H
L
A
A
-
K
G
L
S
C
-
P
L
P
L
P
R
K
--------
D
GEL
L
G
E
L
S
G
---
R
----
P
-----
A
A
L
I
S
F
---
L
E
G
M
-
W
L
R
K
P
------------------------
E
A
K
H
C
R
E
V
G
K
A
L
A
A
M
H
--
L
A
S
E
G
F
E
-----
I
---
K
R
P
-----
N
A
L
--
S
V
-----------
D
G
W
K
V
-
L
W
D
K
S
E
---------
E
----------
R
-------------
A
D
E
------
V
E
---
K
G
-
L
R
E
E
I
R
P
---------
E
I
D
Y
L
------------
A
A
-
H
---
W
-
P
K
D
L
P
A
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
--
L
G
D
------
E
L
S
G
L
I
D
F
---
Y
F
A
C
N
D
L
----
L
A
Y
D
V
S
I
C
L
N
A
W
------------
C
F
------------------
E
KDGAYN-------------------
V
T
K
G
K
A
L
L
-
E
---------------
G
Y
Q
-----
S
V
R
P
---------------
L
S
E
---------
A
E
L
----
E
A
L
P
L
L
S
-
R
G
S
A
L
R
F
---
F
L
T
R
L
Y
--------------------------------------------------------------------------------------
52
HHSearch
66.25
14%
-23
* C1 *
-
4R7B
-
?
A:
[18-297]
-----------------------------------
G
S
H
M
E
K
I
I
K
E
K
I
S
S
L
L
--
S
Q
E
E
-----
E
----
V
L
S
V
E
Q
L
--
G
G
M
T
----
N
Q
N
Y
L
-
A
K
T
--------------------
T
-------
N
---
K
Q
Y
I
V
K
F
F
G
K
G
T
E
K
L
-
I
-
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
-
L
G
L
D
--
V
K
N
Y
L
F
D
--------
I
--------
E
---
A
----
G
-----
I
K
V
N
E
Y
---
I
E
S
A
I
T
L
D
S
T
S
-----------------------
I
K
T
K
F
D
K
I
A
P
I
L
Q
T
I
H
--
T
S
A
K
E
L
R
GE---
F
---
A
-------
P
F
E
--
E
I
-----------
K
K
Y
E
S
-
L
I
E
E
Q
I
---------
P
----------
Y
---------------
A
------
N
Y
---
E
S
-
V
R
N
A
V
F
S
---------
L
E
K
R
L
------------
A
D
--------
L
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
--
S
P
Q
------
G
R
L
Y
L
I
D
W
---
E
Y
S
S
M
N
D
----
P
M
W
D
L
A
A
L
F
L
E
S
------------
E
F
------------------
T
-------------------------
S
Q
E
E
E
T
F
L
-
S
---------------
H
Y
E-----
S
D
Q
T
---------------
P
-----------
V
S
H
----
E
K
I
A
I
Y
K
-
I
L
Q
D
T
I
W
---
S
L
W
T
V
Y
K
E
E
Q
--
G
-----
E
---
D
F
----------
G
D
Y
G
V
N
R
Y
Q
R
A
V
----------------------------------------------