@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : U2D2P5_9FIRM: (2019-02-02 )
MMKLKNLVLNTDQVANAILKNWNHDENSLNFWRGSANYVYFFTLKGDRYWLRFSRKDENSLEQIKAEIEFLLYLKENNFSAVYPIISNNHRYIEVVEDEGETYYAVVFNKAEGVNLEIEDMTEAEFECWGKSLASLHRLSKTFRPKEHVRNSWKQVLEVTSDILSDFPNEQNAKDELKKVEKWLKSLPVTNENYGLIHYDFELDNVFFNKQSRLFKAIDFDSSMYHWYVMDIACTLGDLNELDSPKAEDGLKHFLKGYRSINGIEEEFIDLLPKFERFDNLISFAKLLRSLQDSSFPSEPEWLKRLRPRLLKKCDEYRKGFEKAW
Atome Classification :
(20 SA)
.........10........20..--.--.--.-.-..30.-.-...---...40....-.-.-.-.50.....-----.-..--60...-.....70.....-.-.-.80.......--..90....--....-100.......110..-.----....---120.......130........140-----------.----..---....------------.--.-------150---...--....------..-160----..-..-------------..----------.-----------.-----------------170......--..-----180...------..-.---------.190...-------....200.......210.--.....-..220.......230..-..-----------..-.240---------.---------......250..-.....-260.-........270...-------------------.....280-......---.290-----........300..--...--...310.......320...--------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MM
K
L
K
N
L
VL
N
T
D
Q
V
A
N
A
I
L
K
NWN--H--D--E-N-S
L
N
F
W-R-GSA---
N
Y
V
Y
F
F
T
LK-G-
D
-
R
-
Y
W
L
R
FSRK-----D-EN--
S
L
E
Q
I
-
K
A
E
I
E
F
L
L
Y
L
KE-N-N-F
S
-
A
V
Y
P
IIS--NN
H
R
Y
I
E
V
--VEDE-G
E
T
Y
Y
A
V
V
F
NKAE
G
V
-
N
----
L
E
I
E---DM
T
E
A
E
F
E
C
W
G
-
K
S
L
A
S
L
H
R
L
S
-------------
K
----TF---R
P
K
E
------------
H
--
V
-------
R
-----
N
S
W
--
K
Q
V
L
------
E
V
-
T
S
-----
D
I
-
L
S
-------------DF----------P-----------N-----------------E-Q
N
A
K
D
E
L
--
K
K
-----
V
E
K
W
L
K
------SL-P---------VTNEN
Y
G
-------
L
I
H
Y
D
F
EL
D
N
V
F
FNKQ-
S
--
R
L
F
K
A
-IDFDSS
M
Y
H
W
Y
V
M
D
I
A
C
-TL-----------G
D
-
L
N
EL---------D---------SP
K
A
E
D
G
L
K
H
F
-
L
K
G
Y
R
-S--I-N
G
I
E
E
E
F
I
D
L
-
L
P
K
-------------------
F
E
R
F
D
N
L
I
-
S
F
A
K
L
L
---
R
S
L
------QDSSFPS
E
P
-
E
W
L
--
K
R
L
--
R
P
R
L
L
K
K
C
D
E
Y
R
K
G
F
E
KAW--------------
22
HHSearch
81.55
20%
32
* C2 *
-
6EF6
2
?
A:
[27-346]
----------
D
V
T
I
A
Q
Q
A
L
T
H
Y
D
--
V
--
S
--
D
N
A
-
S
L
R
L
L
-
N
-
L
S
E
---
N
A
T
Y
L
V
E
D
G
-
E
-
H
-
Q
-
S
I
L
R
V
H
R
Q
-----
D
-
Y
H
--
Q
P
H
E
I
-
E
S
E
L
D
W
L
A
A
L
R
T
D
S
-
D
-
V
T
-
V
P
T
V
V
P
A
--
R
D
G
R
R
V
V
T
--
V
D
P
A
D-
V
P
R
H
V
V
H
F
E
M
V
G
G
A
-
E
----
P
D
E
E
---
S
L
T
L
D
D
F
Q
T
L
G
-
R
I
T
A
S
L
H
E
H
S
-------------
Q
----
R
W
---
T
R
P
A
G-----------
F
--
G
-------
R
-----
F
S
W
--
D
W
E
H
------
C
L
G
D
T
-----
P
R
-
W
G
-------------
R
W
----------
Q
DAEGVG
A
----
S
-----------------
E
T
A
L
L
T
R
A
Q
--
D
L
-----
L
H
R
K
L
E
------
E
Y
-
G
---------
S
G
P
D
R
Y
G
-------
L
I
H
A
D
L
R
L
A
N
L
L
V
D
S
S
-
T
PQ
R
T
I
T
V
-
I
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
G
T
-
A
V
-----------
S
F
-
I
E
H
--------------------
D
P
R
L
G
E
W
Q
E
S
W
-
V
A
G
Y
R
-
S
--
R
-
R
E
L
P
A
A
D
E
A
M
-
L
P
S
-------------------
F
V
F
L
R
R
L
L
-
L
L
A
W
M
G
---
S
H
T
------
H
S
R
---
E
S
A
-
T
K
A
--
I
S
Y
--
A
A
G
S
C
A
L
A
E
R
Y
L
---------------------
53
Fugue
76.54
17%
3
- C2 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
-
S
A
F
T
F
Q
T
L
H
P
D
T
I
M
D
A
L
F
E
H
G
I
--
R
--
V
--
D
-
S
-
G
L
T
P
L
-
N
-
S
Y
E
---
N
R
V
Y
Q
F
Q
D
E
D
R
-
R
-
R
-
F
V
V
K
F
Y
R
P
-----
E
-
R
W
--
T
A
D
Q
I
-
L
E
E
H
Q
F
A
L
Q
L
V
N
-
D
-
E
-
V
P
-
V
A
A
P
V
A
F
--
N
G
Q
T
L
L
N
H
--------
Q
G
F
Y
F
A
V
F
P
S
V
G
G
R
-
Q
----
F
E
A
D
---
N
--
I
D
Q
M
E
A
V
G
-
R
Y
L
G
R
M
H
Q
T
G
-------------
R
----
K
Q
---
L
F
I
H
------------
R
--
P
-------
T
-----
I
G
L
--
N
E
Y
L
------
I
E
-
P
R
-----
K
L
-
F
E
-------------
D
A
----------
T
LIPSG------
L
-----------------
K
-
A
A
F
L
K
A
T
--
D
E
-----
L
I
A
A
V
T
------
A
H
-
W
---------
R
E
D
F
T
V
L
-------
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
G
-
P
--
M
F
----
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
-
L
L
-----------
N
G
--------------
D
---------
K
A
E
Q
R
M
Q
L
E
T
I
-
I
E
A
Y
E
-
E
--
F
-
S
E
F
D
T
A
E
I
G
L
-
I
E
P
-------------------
L
R
A
M
R
L
V
Y
-
Y
L
A
W
L
M
---
R
R
W
------
A
D
P
A
F
P
K
N
F
-
P
W
L
TG
E
D
Y
--
W
L
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
E
P
P
LQLTPMY-------
3
PsiBlast_PDB
74.17
19%
-8
- C2 -
-
1ZYL
-
SRKA_ECOLI
A:
[10-297]
-------
T
L
H
P
D
T
I
M
D
A
L
F
E
H
G
I
--
R
--
V
--
D
-
S
-
G
L
T
P
L
-
N
-
S
Y
E
---
N
R
V
Y
Q
F
Q
D
E
-
D
-
R
-
R
R
F
V
V
K
F
Y
R
P
-----
E
-
R
W
--
T
A
D
Q
I
-
L
E
E
H
Q
F
A
L
Q
L
V
N
-
D
-
E
-
V
P
-
V
A
A
P
V
A
F
--
N
G
Q
T
L
L
N
--------
H
Q
G
F
Y
F
A
V
F
P
S
V
G
G
R
-
Q
----
F
E
A
D
---
N
I
D
Q
--
M
E
A
V
G
-
R
Y
L
G
R
M
H
Q
T
G
-------------
R
KQLF
I
H
---
R
P
T
I
------------
G
--
L
NEYL
I
E
P
R
-----
K
L
F
--
E
D
A
T
------
L
I
-
P
S
-----
G
L
-
K
A
-------------
A
F
------------------------------------------
L
K
A
T
D
E
L
I
A
A
V
-----
T
A
H
W
R
E
------
D
F
-
T
---------
V
L
R
------------
L
H
G
D
C
H
A
G
N
I
L
W
-
R
D
-
G
--
P
M
F
---
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
-
L
L
-----------
N
G
--------------
D
---------
K
A
E
Q
R
M
Q
L
E
T
I
-
I
E
A
Y
E
-
E
--
F
-
S
E
F
D
T
A
E
I
G
L
-
I
E
P
-------------------
L
R
A
M
R
L
V
Y
-
Y
L
A
W
L
M
---
R
R
W
------
A
D
P
A
F
P
K
N
F
-
P
W
L
----------------------------------------
1
PsiBlast_PDB
73.34
23%
37
- C2 -
-
6EF6
2
?
A:
[27-306]
----------
D
V
T
I
A
Q
Q
A
L
T
H
Y
D
--
V
--
S
--
D
-
N
A
S
L
R
L
L
-
N
-
L
S
E
---
N
A
T
Y
L
V
E
D
G
-
E
-
H
-
Q
-
S
I
L
R
V
H
R
Q
-----
D
-
Y
H
--
Q
P
H
E
I
-
E
S
E
L
D
W
L
A
A
L
R
T
-
D
-
S
-
D
V
-
T
V
P
T
V
V
P
A
R
D
G
R
R
V
V
T
V
D
P
A
D
----
V
P
R
H
V
V
H
F
E
M
V
G
G
A
-
E
----
P
D
E
E
---
S
L
T
L
D
D
F
Q
T
L
G
-
R
I
T
A
S
L
H
E
H
S
-------------
Q
----
R
W
T--
R
P
A
G
------------
F
--
G
-------
R
-----
F
S
W
--
D
W
------------
E
-----
H
C
-
L
G
-------------
D
T
----------
P
-----------
R
WGRWQDAEGVG
A
S
E
T
A
L
L
-
T
R
A
Q
D
L
L
--
H
R
-----
K
L
E
E
Y
G
------
S
G
-
P
------------
D
R
Y
G
-------
L
I
H
A
D
L
R
L
A
N
L
L
V
D
S
S
-
T
PQ
R
T
I
T
V
-
I
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
G
T
-
A
V
-----------
S
F
-
I
E
H
--------------------
D
P
R
L
G
E
W
Q
E
S
W
-
V
A
G
Y
R
-
S
--
R
-
R
E
L
P
A
A
D
E
A
M
-
L
P
S
-------------------
F
-------------------------------------------------------------------------------
23
HHSearch
73.20
20%
-3
- C2 -
-
2PPQ
-
KHSE_AGRFC
A:
[9-286]
-----------
E
D
E
L
R
N
F
L
T
Q
Y
D
--
V
--
G
S-
L
-
T
-
S
Y
K
G
I
-
A
E------
N
S
N
F
L
L
H
T
T
-
K
-
D
-
P
-
L
I
L
T
L
Y
E
K
------------
K
N
D
L
-
P
F
F
L
G
L
M
Q
H
L
A
A
-
K
-
G
-
L
S
-
C
P
L
P
L
P
R
--
K
D
G
E
L
L
G
E
--
L
-----
S
G
R
P
A
A
L
I
S
F
L
E
G
M
-
W
----
L
R
K
-----
P
E
A
K
H
C
R
E
V
G
-
K
A
L
A
A
M
H
L
A
S
-------------
E
----
G
F
---
E
I
K
R
P
NA---------
L
--
S
-------
V
-----
D
G
W
--
K
V
L
W
------
D
K
-
S
E
-----
E
R
-
A
D
-------------
E
-----------------------
V
-----------------
E
-
K
G
L
R
E
E
I
--
R
P
-----
E
I
D
Y
L
A
------
A
H
-
W
---------
P
K
D
L
P
A
G
-------
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
D
----
E
L
S
G
L
-
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
-
C
L
-----------
N
A
-
W
C
F
E
K--------
D
---------
G
A
Y
N
V
T
K
G
K
A
L
-
L
E
G
Y
Q
-
S
--
V
-
R
P
L
S
E
A
E
L
E
A
-
L
P
L
-------------------
L
S
R
G
S
A
L
R
-
F
F
L
T
R
L
---
Y
D
W
------
L
T
---------------------------------------------------
24
HHSearch
72.80
15%
-14
- C2 -
-
2Q83
4
COTI_BACSU
A:
[19-308]
----------
L
T
E
L
A
E
N
V
L
Q
G
W
D
--
V
--
Q
--
A
-
E
-
K
I
D
V
I
Q--------
A
L
V
W
K
V
H
T
D
-
S
-
G
-
A
-
V
C
L
K
R
I
H
R
-----
P
------
E
K
K
A
-
L
F
S
I
F
A
Q
D
Y
L
A
K
-
K
-
G
-
M
N
-
V
P
G
I
L
P
N
--
K
K
G
S
L
Y
S
K
--
H
-----
G
S
F
L
F
V
V
Y
D
W
I
E
G
R
-
P
----
F
E
L
-----
T
V
K
Q
D
L
E
F
I
M
-
K
G
L
A
D
F
H
T
A
S
-------------
V
----
G
Y
---
Q
P
P
N
G
V
P
I
F
-------
T
--
K
-------
L
-----
G
R
W
--
P
N
H
Y
------
T
K
-
R
C
-----
K
Q
-
M
E
-------------
T
W
K
L
M
A
E
A
E
KED
P
F
S
Q
L
Y
L
Q
----
E
-----------------
I
-
D
G
F
I
E
D
G
--
L
R
-----
I
K
D
R
L
L
Q
ST
Y
V
-
P
W
T
E
---------
Q
L
K
K
S
P
N
-------
L
C
H
Q
D
Y
G
T
G
N
T
L
L
G
E
N
----
E
Q
I
W
V
-
I
D
L
D
T
V
S
F
D
L
P
I
R
D
L
R
K
-
M
I
-----------
I
P
-
L
L
D
T
---------
T
---------
G
V
W
D
D
E
T
F
N
V
M
-
L
N
A
Y
E
-
S
--
R
-
A
P
L
T
E
E
Q
K
Q
V
-
M
F
I
-------------------
D
M
L
F
P
Y
E
-------------------------------------------------------------------------
25
HHSearch
69.59
17%
-15
- C2 -
-
1ZYL
-
SRKA_ECOLI
A:
[12-288]
---------
H
P
D
T
I
M
D
-
A
L
F
E
H
G
--
I
--
R
--
V
D
S
-
G
L
T
P
L
-
N
-
S
Y
E
---
N
R
V
Y
Q
F
Q
D
E
D
R
-
R
-
R
-
F
V
V
K
F
Y
R
P
-----
E
-
R
W
--
T
A
D
Q
I
-
L
E
E
H
Q
F
A
L
Q
L
V
N
-
D
-
E
-
V
P
-
V
A
A
P
V
A
---
F
N
G
Q
T
L
L
N
-------
H
Q
G
F
Y
F
A
V
F
P
S
V
G
G
R
-
Q
----
F
E
A
-----
D
N
I
D
Q
M
E
A
V
G
-
R
Y
L
G
R
M
H
Q
T
G
-------------
R
----
K
Q
---
L
F
I
H
R-----------
P
TI
G
-------
L
-----
N
E
Y
--
L
I
E
P
------
R
K
-
L
F
-----
E
D
-
A
T
-------------
L
I
----------
P
SG---------
L
-----------------
K
-
A
A
F
L
K
A
T
--
D
E
-----
L
I
A
A
V
T
------
A
H
-
W
---------
R
E
D
F
T
V
L
-------
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
------
G
P
M
F
-
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
-
L
L
-----------
N
G
-
D
K
A
----------------------
E
Q
R
M
Q
L
E
T
I
-
I
E
A
Y
E
-
E
--
F
-
S
E
F
D
T
A
E
I
G
L
-
I
E
P
-------------------
L
R
A
M
R
L
V
Y
-
Y
L
A
W
L
M
---
R
R
W
------
A
D
P
--------------------------------------------------
56
Fugue
68.83
14%
4
- C2 -
-
2Q83
5
COTI_BACSU
A:
[11-346]
--
L
S
A
E
D
A
K
K
L
T
E
L
A
E
N
V
L
Q
G
W
D
--
V
--
Q
--
A
-
E
-
K
I
D
V
I
-
Q
-------
A
L
V
W
K
V
H
T
D
-
S
-
G
-
A
-
V
C
L
K
R
I
---------
H
R
--
P
E
K
K
A
-
L
F
S
I
F
A
Q
D
Y
L
A
K
-
K
-
G
M
N
V
-
P
G
I
L
P
N
K
--
K
G
S
L
Y
S
K
H
--------
G
S
F
L
F
V
V
Y
D
W
I
E
G
R
-
P
----
F
E
L
T
---
V
K
Q
D
L
E
F
---
I
M
K
G
L
A
D
F
H
T
A
S
-------------
V
----
G
Y
---
Q
P
P
N
------------
G
--
V
-------
P
I
F
T
KL
G
R
W
--
P
N
H
Y
------
T
K
-
R
C
-----
K
Q
M
E
T
-------------
W
K
----------
L
M
----------
A
E
A
E
KED
P
F
S
Q
L
Y
-----
L
-
Q
E
I
D
G
F
I
--
E
D
-----
G
L
R
I
K
D
------
R
L
-
L
Q
ST
Y
V
P
W
T
E
Q
L
K
K
S
P
N
-------
L
C
H
Q
D
Y
G
T
G
N
T
L
L
G
E
N
-
E
--
Q
-
I
W
V
-
I
D
L
D
T
V
S
F
D
L
P
I
R
D
L
R
K
M
I
I
-----------
P
L
-
L
--
D
---------
T
---------
T
G
V
W
D
D
E
T
F
N
V
M
L
N
A
Y
E
-
S
--
R
-
A
P
L
T
E
E
Q
K
Q
V
M
F
I
---------------------------
D
M
L
F
P
Y
E
L
---
Y
D
V
------
I
R
E
K
Y
V
R
K
S
-
A
L
P
--
K
E
E
--
L
E
S
A
F
E
Y
E
R
I
K
A
N
A
L
R
Q
L
I
--------------
55
Fugue
65.63
16%
31
- C2 -
-
3I1A
2
?
A:
[3-330]
-----
K
Q
P
I
Q
A
Q
Q
L
I
E
L
L
K
V
H
Y
G
--
I
--
D
--
I
-
H
-
T
A
Q
F
I
-
Q
-
G
G
A
DTN
A
F
A
Y
Q
A
D
S
E
-
S
-
K
-
S
-
Y
F
I
K
L
K
Y
--------
G
Y
--
H
D
E
I
N
-
L
S
I
I
R
L
L
H
D
S
G
I
-
K
-
E
-
I
I
-
F
P
I
H
T
L
E
--
A
K
L
F
--------
Q
Q
-
L
K
H
F
K
I
I
A
Y
P
F
I
H
A
P
-
N
----
G
F
T
Q
---
N
L
T
G
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
I
H
E
T
S
V
P
I
S
I
Q
Q
Q
LRKEI
Y
----
S
P
---
K
W
R
E
------------
I
--
V
-------
R
-----
S
F
Y
--
N
Q
I
E
FDNSDD
K
L
-
T
A
-----
A
F
-
K
S
-------------
F
F
----------
N
Q
----------
N
-----------------
S
-
A
A
I
H
R
L
V
--
D
T
-----
S
E
K
L
S
K
------
K
I
-
Q
---------
P
D
L
D
K
Y
V
-------
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
E
-
E
--
S
-
I
Y
I
-
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
-
I
G
-----------
G
G
-
V
G
-----------
N
---------
V
W
N
K
P
H
E
I
Q
Y
F
-
Y
E
G
Y
G
-
E
--
I
-
N
-
V
D
K
T
I
L
S
Y
-
Y
R
H
-------------------
E
R
I
V
E
D
I
A
-
V
Y
G
Q
D
L
L
--
S
R
N
------
Q
N
N
Q
S
R
L
E
S
F
K
Y
F
--
K
E
M
F
D
P
N
N
V
V
E
I
A
F
A
T
E
---------------------
21
HHSearch
64.95
13%
-23
- C2 -
-
4PDY
1
?
A:
[22-306]
------------
L
I
P
Q
A
V
V
S
K
Y
D
--
L
--
A
--
I
-
Q
-
Q
R
-------
H
A
---
D
G
N
I
E
V
W
T
D
S
K
-
G
R
R
-
Y
A
A
K
R
S
S
I
-----
A
------
P
A
H
C
-
R
I
M
V
Q
C
L
R
H
A
Q
E
-
Q
-
G
-
F
T
K
F
A
R
F
V
T
T
--
S
S
N
A
P
Y
V
R
--
H
-----
G
D
F
T
Y
Y
V
T
E
W
V
S
G
Q
-
P
----
A
N
F
-----
G
L
P
E
H
V
A
Q
T
A
-
Y
T
L
A
Q
F
H
E
A
T
-------------
R
----
S
F
---
R
T
D
W
K----------------------------
D
D
V
--
F
G
L
F
------
Q
A
-
R
W
-----
R
D
-
L
R
Q
M
W
L
G
A
D
R
KREKD
A
F
----------
D
Q
L
L
L
S
------
M
-----------------
R
-
D
E
L
H
R
D
A
--
A
E
-----
S
L
A
L
F
E
D
R
D
V
I
A
Y
L
-
E
---------
A
E
R
S
S
G
G
-------
W
C
H
L
D
V
I
P
S
N
C
L
Y
T
P
Q
----
H
Q
V
V
L
-
I
D
F
E
L
A
R
P
A
P
R
A
L
D
M
A
H
-
L
L
-----------
R
R
-
S
L
E
----------
R
---------
G
N
W
D
G
H
L
A
Y
A
C
-
F
L
H
F
D
-
A
--
V
-
R
N
I
P
K
S
E
Y
R
A
-
V
E
A
-------------------
I
L
R
F
P
Y
L
P
-
W
----------------------------------------------------------------------
29
HHSearch
60.37
18%
1
- C2 -
-
5IGH
-
?
A:
[9-258]
-----------
T
S
Q
L
Y
A
L
A
A
R
H
G
--
L
--
K
--
L
H
G
-
P
L
T
V
N
-
E
L
G
L
D
---
Y
R
I
V
I
A
T
V
D
-
D
G
R
-
R
-
W
V
L
R
I
P
R
R
-----
A
-
E
---
V
S
A
K
V
-
E
P
E
A
R
V
L
A
M
L
K
N
-
R
L
P
-
F
A
-
V
P
D
W
R
V
A
--
N
A
E
-
L
V
-
A
--
Y
P
M
L
--
E
D
--
S
T
A
M
V
I
Q
P
G
S
-
S
----
T
P
D
W
V
V
P
Q
D
S
E
V
F
A
E
S
F
A
-
T
A
L
A
A
L
H
A
V
P
-------------
I
----
S
A
---
A
V
D
A
G-----------
M
--
L
I
R
T
----
P
-----
T
Q
A
--
R
Q
K
V
------
A
D
-
D
V
-----
D
R
-
V
R
-------------
R
-----------------------
E
-----------------
F
-
V
V
N
D
K
R
L
--
H
R
-----
W
Q
R
W
L
D
------
D
D
-
S
---------
S
W
P
D
F
S
V
-------
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T
-
E
--
R
V
S
G
M
-
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
-
H
L
-----------
M
V
-
F
G
-------------------------
E
E
G
L
A
K
L
-
L
L
T
Y
E
-
A
--
A
-
G
G
R
V
-------------------------------------------------------------------------------------------------------------
30
HHSearch
60.33
18%
1
- C2 -
-
5IGI
3
?
A:
[9-258]
-----------
T
S
Q
L
Y
A
L
A
A
R
H
G
--
L
--
K
--
L
H
G
-
P
L
T
V
N
-
E
L
G
L
D
---
Y
R
I
V
I
A
T
V
D
-
D
G
R
-
R
-
W
V
L
R
I
P
R
R
-----
A
-
E
---
V
S
A
K
V
-
E
P
E
A
R
V
L
A
M
L
K
N
-
R
L
P
-
F
A
-
V
P
D
W
R
V
A
--
N
A
E
-
L
V
-
A
--
Y
P
M
L
--
E
D
--
S
T
A
-
V
I
Q
P
G
S
-
S
----
T
P
D
W
VVP
Q
D
S
E
V
F
A
E
S
F
A
-
T
A
L
A
A
L
H
A
V
P
-------------
I
----
S
A
---
A
V
D
A
G-----------
M
--
L
IRT----
P
-----
T
Q
A
--
R
Q
K
V
------
A
D
-
D
V
-----
D
R
-
V
R
-------------
R
-----------------------
E
-----------------
F
-
V
V
N
D
K
R
L
--
H
R
-----
W
Q
R
W
L
D
------
D
D
-
S
---------
S
W
P
D
F
S
V
-------
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T
-
E
--
R
V
S
G
M
-
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
-
H
L
-----------
M
V
-
F
G
-------------------------
E
E
G
L
A
K
L
-
L
L
T
Y
E
-
A
--
A
-
G
G
R
V
-------------------------------------------------------------------------------------------------------------
61
Fugue
59.29
12%
-10
- C2 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
--
K
T
P
L
Y
E
T
L
N
E
S
S
A
V
A
L
A
V
K
L
G
--
L
--
T
--
L
-
T
-
C
Q
E
I
G
-
D
-
G
N
L
---
N
Y
V
F
H
I
Y
---
D
-
R
-
A
-
L
I
I
K
Q
A
V
P
-----
Y
-
W
P
L-
T
I
D
R
A
-
R
I
E
S
S
A
L
I
R
Q
G
E
-
H
-
V
-
P
H
-
L
V
P
R
V
F
Y
--
S
D
T
E
M
A
V
T
--
V
M
E
D
-
L
S
H
L
--
K
I
A
R
K
G
L
I
E
-
G
----
E
N
Y
P
---
H
L
S
Q
H
I
G
E
F
L
G
-
K
T
L
F
Y
S
S
D
Y
A
-------------
L
----
E
P
---
K
V
K
K
------------
Q
--
L
-------
V
-----
K
Q
F
TN
P
E
L
C
------
D
I
-
T
E
-----
R
L
-
V
F
-------------
T
D
----------
P
FFDHDT
N
D
F
E
E
E
-----------------
L
-
R
P
F
V
E
K
L
--
W
N
-----
N
D
S
V
K
I
------
E
A
-
A
---------
K
L
K
K
S
F
L
TSAET--
L
I
H
G
D
L
H
T
G
S
I
F
A
S
E
H
-
E
----
T
K
V
-
I
D
P
E
F
A
F
Y
G
P
I
G
F
D
V
G
Q
-
F
I
-----------
A
N
-
L
F
L
N
---------
A
---------
L
S
R
D
G
A
D
R
E
P
L
-
Y
E
H
V
N
-
Q
--
V
W
E
T
F
E
E
T
F
S
E
A
-
W
Q
K
DSLDVYANIDG
Y
L
T
D
T
L
S
H
I
F
E
E
A
I
G
F
-
A
G
C
E
L
I
---
R
R
T
IGLAHV
A
D
L
D
T
I
V
P
F
-
D
K
R
--
I
G
R
--
K
R
L
A
L
E
T
G
T
A
F
I
E
K
R
S
E
F
K
T
I
T
D
V
I
E
L
F
K
L
L
V
K
64
Fugue
57.49
15%
40
- C2 -
-
4OCV
2
?
A:
[24-378]
----------
T
N
E
A
L
F
D
V
A
S
H
F
A
LE
G
--
T
--
V
-
D
-
S
I
E
P
Y
G
D
-
G
H
I
---
N
T
T
Y
L
V
T
T
D
-
G
-
P
-
R
-
Y
I
L
Q
R
M
N
T
GIFPD
T
-
V
N
--
L
M
R
N
V
-
E
L
V
T
S
T
L
K
A
Q
G
K
-
E
-
T
-
L
D
-
I
V
R
T
--
T
--
S
G
D
T
W
A
E
I
-----
D
-
G
G
A
W
R
V
Y
K
F
I
E
H
T
M
S
-
Y
----
N
L
V
P
---
N
--
P
D
V
F
R
E
A
G
-
R
A
F
G
D
F
Q
N
F
L
-------------
S
----
G
F
---
D
A
N
Q
LTETIAHFHD
T
P
H
--
R
-------
F
-----
E
D
F
--
K
K
A
L
------
A
A
------------
D
-------------
E
L
----------
G
-----------
R
-----------------
A
-
A
G
C
G
P
E
I
--
E
F
-----
Y
L
S
H
A
D
------
Q
Y
-
A
---------
V
V
M
D
G
L
R
D
GSIPLR
V
T
H
N
D
T
K
L
N
N
I
L
M
D
A
T
-
T
--
G
K
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
-
S
I
R
F
GASTALEDE
R
D
-
L
D
K
V
H
F
-------
S
---------
T
E
L
F
R
A
Y
T
E
G
F
-
V
G
E
L
R
D
S
--
I
-
T
A
R
E
A
E
L
L
P
F
-
S
G
N
-------------------
L
L
T
M
E
C
G
M
-
R
F
L
A
D
Y
L
E
G
D
V
Y
------
F
A
T
K
Y
P
E
H
N
-
L
V
R
--
S
R
T
--
Q
I
K
L
V
R
E
M
E
Q
R
A
D
E
T
R
A
I
V
A
D
V
M
E
T
T-------
32
HHSearch
55.84
17%
-1
- C2 -
-
4R78
2
?
A:
[38-277]
----------------------------
E
--
V
-
L
-
S
V
E
Q
L
-
G
-
G
M
T
---
N
Q
N
Y
L
A
K
T
T
-
N
-
K
-
Q
-
Y
I
V
K
F
F
G
K
-----
G
-
T
E
--
K
L
I
N
R
-
Q
D
E
K
Y
N
L
E
L
L
K
D
-
L
-
G
-
L
D
-
V
K
N
Y
L
F
D
--
I
E
--------------
A
G
--
I
K
V
N
E
Y
I
E
S
A
I
T
----
L
D
S
T
----
S
I
K
T
K
F
D
K
I
A
-
P
I
L
Q
T
I
H
T
S
A
-------------
K
----
E
L
---
R
G
E
F
------------
A
--
P
-------
F
E
E
I
--
K
K
Y
--
E
S
L
I
------
E
---------
E
Q
-
I
P
--------------
Y
----------
A
-----------
N
-----------------
Y
-
E
S
V
R
N
A
V
--
F
S
-----
L
E
K
---------
R
L
-
A
---------
D
L
G
V
D
R
K
-------
S
C
H
I
D
L
V
P
E
N
F
I
E
S
P
Q
----
G
R
L
Y
L
-
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
-
L
F
-----------
L
E
-
S
E
F
-----------------------
T
S
Q
E
E
E
T
F
-
L
S
H
Y
E
-
S
--
D
-
Q
T
P
V
S
H
--
E
K
-
I
A
I
-------------------
Y
K
I
L
Q
D
T
I
-
W
S
L
W
T
V
---
Y
-------------------------------------------------------------
26
HHSearch
55.36
13%
26
- C2 -
-
4OCV
2
?
A:
[24-323]
----------
T
N
E
A
L
F
D
V
A
S
H
F
A
--
L
--
E
GT
V
-
D
-
S
I
E
P
Y
-
G
D
G
H
I
---
N
T
T
Y
L
V
T
T
D
-
G
-
P
-
R
-
Y
I
L
Q
R
M
N
T
-----
G
-
I
F
P-
D
T
V
N
L
M
R
N
V
E
L
V
T
S
T
L
K
A
-
Q
-
G
-
K
E
-
T
L
D
I
V
R
T
--
T
S
G
D
T
W
A
E
--
I
-----
D
G
G
A
W
R
V
Y
K
F
I
E
H
T
-
M
----
S
Y
N
L
---
V
P
N
P
D
V
F
R
E
A
G
-
R
A
F
G
D
F
Q
N
F
L
-------------
S
----
G
F
---
D
A
N
Q
------------
L
TE
T
IAH----
F
-----
H
D
T
--
P
H
R
F
------
E
D
-
F
K
-----
K
A
-
L
A
A
DELGRAA-----
G
C
----------
G
P
----------
E
-----------------
I
-
E
F
Y
L
S
H
A
--
D
Q
-----
Y
A
V
V
M
D
------
G
L
-
R
---------
D
G
S
I
P
L
R
-------
V
T
H
N
D
T
K
L
N
N
I
L
M
D
A
T
T
G
--
K
A
R
A
I
-
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
-
S
I
-----------
R
F
-
G
A
S
T
ALEDERDLD
K
---------
V
H
F
S
T
E
L
F
R
A
Y
-
T
E
G
F
V
-
G
E
L
R
-
D
S
I
T
A
R
E
A
E
L
-
L
P
F
-------------------
S
G
N
L
L
T
M
E
-
C
----------------------------------------------------------------------
2
PsiBlast_PDB
55.35
27%
-28
- C2 -
-
2PPQ
-
KHSE_AGRFC
A:
[122-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
K
A
L
A
A
M
H
L
A
S
-------------
E
----
G
F
E
I
K
R
P
N
A
------------
L
--
S
-------
V
-----
D
G
W
--
K
V
L
W
------
D
K
-
S
E
-----
E
R
-
A
D
-------------
E
V
----------------------------------------
E
-
K
G
L
R
E
E
I
--
R
P
E
I
D
Y
L
A
A
H
W
P
K
------
D
L
-
P
---------
A
-----
G
-------
V
I
H
A
D
L
F
Q
D
N
V
F
F
-
L
G
-
D
--
E
L
S
G
L
-
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
-
C
L
-----------
N
A
W
C
F
E
K
---------
D
---------
G
A
Y
N
V
T
K
G
K
A
L
-
L
E
G
Y
Q
-
S
--
V
-
R
P
L
S
E
A
E
L
E
A
-
L
P
L
-------------------
L
S
R
G
S
A
L
R
-
F
F
---------------------------------------------------------------------
27
HHSearch
55.05
13%
21
- C2 -
-
4WH3
8
NAHK_BIFL2
A:
[5-302]
-----------
N
E
V
L
F
G
I
A
S
H
F
A
--
L
EG
A
--
V
-
T
-
G
I
E
P
Y
-
G
D
G
H
I
---
N
T
T
Y
L
V
T
T
D
-
G
-
P
-
R
-
Y
I
L
Q
Q
M
N
T
-----
S
-
I
F
PD
T
V
N
L
M
-
R
N
V
E
L
V
T
S
T
L
K
A
-
Q
-
G
-
K
E
-
T
L
D
I
V
P
T
--
T
S
G
A
T
W
A
E
--
I
-----
D
G
G
A
W
R
V
Y
K
F
I
E
H
T
-
V
----
S
Y
N
L
---
V
P
N
P
D
V
F
R
E
A
G
-
S
A
F
G
D
F
Q
N
F
L
-------------
S
----
E
F
---
D
A
S
Q
L-----------
T
E-
T
IAH----
F
-----
H
D
T
--
P
H
R
F
------
E
D
-
F
K
-----
A
A
-
L
A
A
DKLG--------
R
A
----------
A
-----------
A
C
Q
P
E
-------------
I
-
D
F
Y
L
S
H
A
--
D
Q
-----
Y
A
V
V
M
D
------
G
L
-
R
---------
D
G
S
I
P
L
R
-------
V
T
H
N
D
T
K
L
N
N
I
L
M
D
A
T
T
G
--
K
A
R
A
I
-
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
-
S
I
-----------
R
F
-
G
A
S
T
---------
A
LEDEKDLSK
V
H
F
S
T
E
L
F
R
A
Y
-
T
E
G
F
V
-
G
E
L
R
-
G
S
I
T
A
R
E
A
E
L
-
L
P
F
-------------------
S
G
N
L
L
T
M
E
------------------------------------------------------------------------
33
HHSearch
53.46
17%
2
- C2 -
-
4R7B
-
?
A:
[38-277]
----------------------------
E
--
V
-
L
-
S
V
E
Q
L
-
G
-
G
M
T
---
N
Q
N
Y
L
A
K
T
T
-
N
-
K
-
Q
-
Y
I
V
K
F
F
G
K
-----
G
-
T
E
--
K
L
I
N
R
-
Q
D
E
K
Y
N
L
E
L
L
K
D
-
L
-
G
-
L
D
-
V
K
N
Y
L
F
D
--
I
E
--------------
A
G
--
I
K
V
N
E
Y
I
E
S
A
I
T
----
L
D
S
T
----
S
I
K
T
K
F
D
K
I
A
-
P
I
L
Q
T
I
H
T
S
A
-------------
K
----
E
L
---
R
G
E
F
------------
A
--
P
-------
F
E
E
I
--
K
K
Y
--
E
S
L
I
------
E
---------
E
Q
-
I
P
--------------
Y
----------
A
-----------
N
-----------------
Y
-
E
S
V
R
N
A
V
--
F
S
-----
L
E
K
---------
R
L
-
A
---------
D
L
G
V
D
R
K
-------
S
C
H
I
D
L
V
P
E
N
F
I
E
S
P
Q
----
G
R
L
Y
L
-
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
-
L
F
-----------
L
E
-
S
E
F
-----------------------
T
S
Q
E
E
E
T
F
-
L
S
H
Y
E
-
S
--
D
-
Q
T
P
V
S
H
--
E
K
-
I
A
I
-------------------
Y
K
I
L
Q
D
T
I
-
W
S
L
W
T
V
---
Y
-------------------------------------------------------------
44
SP3
53.38
12%
6
- C2 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
---------
A
K
M
R
I
S
P
E
L
K
K
L
I
E
--
K
--
Y
--
R
-
C
-
V
K
D
T
E
-
G
-
M
S
P
---
A
K
V
Y
K
L
V
G
E
-
N
-
E
-
N
-
L
Y
L
K
M
T
D
S
-----
R
Y
K
G
--
T
T
Y
D
V
-
E
R
E
K
D
M
M
L
W
L
E
G
---
K
-
L
P
-
V
P
K
----------
V
L
H
F
--
E
R
H
D
-
G
--
W
S
N
L
L
M
S
E
A
D
G
V
-
L
C
S
E
E
Y
E
D
E
---
Q
S
P
E
K
I
I
E
L
Y
A
-
E
C
I
R
L
F
H
S
I
D
-------------
I
----
S
D
---
C
P
Y
T
------------
N
--
S
-------
L
-----
D
S
R
--
L
A
E
L
------
D
Y
-
L
L
N
N
DLA
D
V
-
D
C
-------------
E
N
----------
W
-----------
E
-----------------
E
-
D
T
P
F
K
D
P
--
R
E
-----
L
Y
D
F
L
K
------
T
E
-
K
---------
P
-
E
E
E
L
V
-------
F
S
H
G
D
L
G
D
S
N
I
F
V
K
-
D
-
G
--
K
V
S
G
F
-
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
-
C
V
-----------
R
S
-
I
R
E
D
---------
I
---------
G
E
--
E
Q
Y
V
E
L
F
-
F
D
L
L
G
---------
I
K
P
D
W
E
K
-
I
K
Y
-------------------
Y
I
L
L
D
E
L
F
------------------------------------------------------------------------