Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MDDFAEWVRVAFGLGEGPLVRTVGGRGADGDVWHLRVRDREYAVKRPFRAF-DPAAVRHEAALLEHLTSGGVEVPTHVASPEGQLVVEVPDHLGGGNARVSHWVTGT-SVTDR-TSEVAEQLGTLLAQLHRAAPATWDRPRSWHTAMVPPDEWAELVRRSSGQPWHQALVARHD-DLTAYAEVVDRAGPGTGPFVLGHCDLHPDNALAAPDGSLRALDWEDCGPVDPTRELAKTLVQWHVLGESVDDDAITKTVAAYRDAGGPGLLADTPDFAMVLCSET-NFLANQVRLALDVSAPGERRDQARGEITEALADYLPSIAALERVLSVTRPG 4R78 Chain:A ((40-275)) ------------------LSVEQL-GGMTNQNYLAKTTNKQYIVKFFGKGTEKLINRQDEKYNLELLKDLGLDVKNYLFDI-------------EAGIKVNEYIESAITLDSTSIKTKFDKIAPILQTIHTSAKEL-R-GEFAP-FEE----IKKYES-LIEEQIPYANYESVRNAVFSLEKRL---ADLGVDRKSCHIDLVPENFIESPQGRLYLIDWEYSSMNDPMWDLAALFLESEF-----TSQEEETFLSHYESDQTPVSHEKIAIYKILQDTIWSLWT------------------------------------------------

General information: TITO was launched using: RESULT: Template: 4R78.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1019 17597 17.27 76.18 target 2D structure prediction score : 0.66 Monomeric hydrophicity matching model chain A : 0.63 3D Compatibility (PKB) : 17.27 2D Compatibility (Sec. Struct. Predict.) : 0.66 1D Compatibility (Hydrophobicity) : 0.63 QMean score : 0.290

(partial model without unconserved sides chains): PDB file : Tito_4R78.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4r78-query.scw PDB file : Tito_Scwrl_4R78.pdb: