Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MVELTDPDLERLRRRLAPA-HI----EDLRPLTGGASSLTYAGQRLGDRVVVKMAPPGIQPTRNRDVLRQCRIIKALRATPVPVPDVLWADAGDPPEIPPLFVMSWIDGSSLEPLFDLDCACESEDIVAERFRSAAATMAQLHRIQPAAIGLGSE--PIVGAEAEIDRWCRALETVDPTLAAGWIDLGKALRAAAPP--PLPPAVVHGDFRLGNLRAVD--GRITGVLDWEIWSVGDPRVDVGWFLINCDRQT--YQ---RATPYAGATPSPAELVSIYCAAAGYRL-PDLAWFQALACFKSAATWSLIVKHNRRRHRPDANVEAMAQVLPHLLSRACILLD 3DXP Chain:A ((20-354)) -----RFDTEALEAWMRQHVEGFAGPLSVEQFKG-QSNPTFKLVTPGQTYVMRAKPG--------AIEREYRVMDALAGTDVPVAKMYALCEDESVIGRAFYIMEFVSGRVLWDQSLP-G--MSPAERTAIYDEMNRVIAAMHTVDYQAIGLGDYGKPGNYFQRQIERWTKQYKLSETESIPAMDSLMDWLPQHIPQEDADLTSIVHGDYRLDNLMFHPTEPRVLAVLDWELSTLGHPMGDFGYHCMSWHIAPGQFRGIAGLDHAALGIPDEASYRKLYEQRTGRPITGDWNFYLAFSMFRIAGILQGIMKRVVDGTASSAQALDAGKRARPMAEMGWEYA-

General information: TITO was launched using: RESULT: Template: 3DXP.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1371 -27726 -20.22 -90.31 target 2D structure prediction score : 0.67 Monomeric hydrophicity matching model chain A : 0.70 3D Compatibility (PKB) : -20.22 2D Compatibility (Sec. Struct. Predict.) : 0.67 1D Compatibility (Hydrophobicity) : 0.70 QMean score : 0.467

(partial model without unconserved sides chains): PDB file : Tito_3DXP.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3dxp-query.scw PDB file : Tito_Scwrl_3DXP.pdb: