@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : A0BI55_PARTE: (2019-01-25 )
MSISEVQHQLNLTSYLNQQATVSVFLGVKEIQIDQVQQLATHTYKLTFKNSNKKIILHTKSSNAQVTGNQLEKDYMIAQKLSAANMPVPKALFYCGDQSIVGVPFYATEYVEGRLFNDKKLLSVSQTEKKLLFQEVSKALAHLHSISLNYLGLGELESQTSQYQTLNKKLYNLYKLHETKISTNVEDLLYWLSLNSPVKSELDNLCLVHGDFSLSKVVFHPTEPKVLAILDWQQAQLGNAFIDLASFVSPYYIPYSNGQHQIDGWFGIEEIIAQPNLQEVLSAYFTTRSSETTQDINYQLVISLLKQSIDQQILYKQTKEEKYQDNSHFISKAGYELLLRTTEGDPFGIKLRANNDGQLWSNWPVSQRCKSYYYRIKDFMKDEIFPVEKAILDKARAVPRTVKNKPIVEIEELQRKAKAVGLWNLFISDPMYGKGLTNLEYVYLSELMGLSYLAHEVFNCFAPETGNIKLLIAYGTPHQKEKYLKPLLEGQCKSFFAMTEKDVPSSDPNNFQCTITPTEGGFILNGGKWFVSSAPDERAIFGIVMGKSSKDMSNPIESQSMILVDMNNPKIKIVRQYSVLGFFDVPHGYSEVEFDNAFIPQENLLGQLGGAFKMAQGRLLGGRLHHCVRQIGLTRRCLDLMMARSEKRIIFKQSLKDNAAFQERLGDLEIAFQSCRLLSLNAGLLLDSAGSRHLHTFMAVSECKAHIPKACQYIIDQCIQAFGAEGVTEEQPLTLAYRFARAIRFMDGPCEIHLRQISRFAYGNHLFNDLNNAQGYGLAKL
Atome Classification :
(31 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390..------..------..-.400.--......410.....-..420.......430......---.440.......-------.-------450.-.......460........470.......480.......490.......500.......-510.....--..520-........530.--.--.....540-........550.......---560.....---------..570.......580....-.-.------------.590.......600....-...610.......620.......630.......640.......650.......660.......670.......680.--------......------690----------------......----..---700.......710.......720.......730.......740.--......750.......760.......770.......780------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
I
S
E
V
Q
H
Q
L
N
L
T
S
Y
LNQQ
A
T
V
S
V
F
L
G
V
K
E
I
Q
I
D
Q
V
Q
Q
L
A
T
H
T
Y
K
L
T
FKNSN
K
K
I
I
L
H
TKSSN
A
Q
VTG
N
Q
L
E
K
D
Y
M
I
A
Q
K
LSAANMPV
P
K
A
L
F
YCGDQ
S
I
VGVP
F
Y
A
T
E
YVEGRLFNDK
K
L
L
S
V
S
Q
T
E
K
K
L
L
F
Q
E
V
S
K
A
L
A
H
L
H
SI
S
L
N
Y
LGL
G
E
L
E
S
Q
T
S
Q
Y
Q
T
L
N
K
K
L
Y
N
L
Y
K
L
H
E
TKIST
N
V
E
D
L
L
Y
W
LSLNS
P
V
K
S
E
LD
N
L
C
L
V
HGDFS
L
S
K
V
V
FHPTE
P
K
V
L
A
I
L
D
W
Q
Q
A
QL
G
N
A
F
I
D
L
A
S
FVS
P
Y
Y
I
PYSNGQHQI
D
G
W
F
G
I
E
E
I
IAQP
N
L
Q
E
V
L
S
A
Y
F
TTRSSETTQD
I
N
Y
Q
L
V
I
S
L
L
K
Q
S
I
D
Q
Q
I
L
Y
K
Q
T
K
E
E
KYQDNS
H
F
I
S
KAG
Y
E
L
L
L
R
TTEGD
P
F
G
I
K
L
R
ANNDGQLWSNW
P
V
S
Q
R
C
K
S
Y
Y
Y
R
I
K
D
F
M
KDEIF
P
V
E
K
A
I
L
D
K
------
A
R------AV-PRTVK--NKPIV
E
I
E
E
L
Q
R
K
A
-
K
A
V
G
L
W
N
L
FISDPMYGKGLT
N
---
L
E
-
Y
V
Y
L
S
E
L
M
-------
G
-------
L
S
-
Y
-
L
A
H
E
V
F
N
C-FAPETG
N
I
K
L
L
I
A
YGT
P
H
Q
K
E
K
Y
L
K
P
L
L
E
G
Q
C
K
S
F
F
A
M
T
EKDVPSSDPN-
N
F
Q
C
T
I
TP--TEG
G
--
F
I
LNG
G
K
W
F
VSS--A--PDE
R
A
I
F
--
G
I
V
MGKSSKDMSNPIESQ---
S
M
I
L
V
DMN---------NP
K
I
K
I
V
R
Q
Y
S
V
L
G
F
F
DVP-H-G------------YSEVEFDNAFI
P
Q
E
N
L
L
G
-
Q
LGG
A
F
K
MAQGRL
L
G
G
R
L
H
H
C
V
R
Q
I
G
L
T
R
R
C
L
D
L
M
M
ARSE
K
R
I
I
F
K
Q
SLKD
N
A
A
F
Q
E
RLG
D
L
E
I
A
F
Q
S
C
R
L
L
SLNA
G
--------
L
L
LDSA------GS-----------------
R
H
L
H
T
F
----
M
A
---
V
S
E
C
K
A
H
I
P
K
A
C
Q
Y
I
I
D
Q
C
I
Q
A
FGAEGVTEEQ
P
L
T
L
A
Y
R
F
A
R
A
I
--RFMDGP
C
E
I
H
L
R
Q
I
S
R
F
A
Y
G
N
H
L
F
N
DLNNAQGYGLAKL-------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
86.06
37%
-24
- C2 -
-
2WBI
2
ACD11_HUMAN
B:
[22-413]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
---
T
R
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G
Q
E
V
L
I
K
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F
M
K
Q
H
I
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P
A
E
K
E
V
T
E
F
------
Y
V
------
Q
N
-
E
N
S
V
D
KW
G
K
P
L
V
-
I
D
K
L
K
E
M
A
-
K
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E
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L
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N
L
F
L
--
P
A
V
S
-
G
L
S
H
---
V
D
-
Y
A
L
I
A
E
E
T
-------
G
-------
K
C
-
F
-
F
A
P
D
V
F
N
C
-
Q
A
P
D
T
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N
M
E
V
L
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L
Y
G
S
E
E
Q
K
K
Q
W
L
E
P
L
L
Q
G
N
I
T
S
C
F
C
M
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E
P
D
V
A
S
S
D
A
T
-
N
I
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--
D
E
D
S
--
Y
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I
N
G
K
K
W
W
S
S
G
--
A
--
G
N
P
K
C
K
I
--
A
I
V
L
G
R
T
Q
N
T
S
-----
Q
H
---
S
M
I
L
V
P
M
N
---------
T
P
G
V
K
I
I
R
P
L
S
V
F
G
Y
T
D
N
F
-
H
G
G
------------
H
F
E
I
H
F
N
Q
V
R
V
P
A
T
N
L
I
L
-
G
E
G
R
G
F
E
I
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Q
G
R
L
G
P
G
R
I
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H
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M
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G
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A
E
R
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A
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R
I
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F
K
K
K
L
Y
A
H
E
V
V
A
H
W
I
A
E
S
R
I
A
I
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K
I
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L
L
T
L
K
A
A
--------
H
S
M
D
T
L
------
G
S
-----------------
A
G
A
K
K
E
----
I
A
---
M
I
K
V
A
A
--
P
R
A
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S
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I
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A
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C
G
G
A
G
V
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Q
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Y
P
L
A
N
M
Y
A
I
T
R
V
L
--
R
L
A
D
G
P
D
E
V
H
L
S
A
I
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.49
37%
-26
- C2 -
-
2WBI
2
ACD11_HUMAN
A:
[22-413]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
---
T
R
K
G
Q
E
V
L
I
K
V
K
H
F
M
K
Q
H
I
L
P
A
E
K
E
V
T
E
-----------------------KW
G
K
P
L
V
-
I
D
K
L
K
E
M
A
-
K
V
E
G
L
W
N
L
F
L
--
P
A
V
S
-
G
L
S
H
---
V
D
-
Y
A
L
I
A
E
E
T
-------
G
-------
K
C
-
F
-
F
A
P
D
V
F
N
C
-
Q
A
P
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T
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N
M
E
V
L
H
L
Y
G
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E
E
Q
K
K
Q
W
L
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P
L
L
Q
G
N
I
T
S
C
F
C
M
T
E
P
D
V
A
S
S
D
A
T
-
N
I
E
C
S
I
Q
R
--
D
E
D
S
--
Y
V
I
N
G
K
K
W
W
S
S
G
--
A
--
G
N
P
K
C
K
I
--
A
I
V
L
G
R
T
Q
N
T
S
L
S
R
H
K
Q
H
---
S
M
I
L
V
P
M
N
---------
T
P
G
V
K
I
I
R
P
L
S
V
F
G
Y
T
D
N
F
-
H
G
G
------------
H
F
E
I
H
F
N
Q
V
R
V
P
A
T
N
L
I
L
-
G
E
G
R
G
F
E
I
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Q
G
R
L
G
P
G
R
I
H
H
C
M
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G
L
A
E
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A
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E
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A
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R
I
A
F
K
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K
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Y
A
H
E
V
V
A
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W
I
A
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S
R
I
A
I
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I
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L
L
T
L
K
A
A
--------
H
S
M
D
T
L
------
G
S
-----------------
A
G
A
K
K
E
----
I
A
---
M
I
K
V
A
A
--
P
R
A
V
S
K
I
V
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W
A
I
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V
C
G
G
A
G
V
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Q
D
Y
P
L
A
N
M
Y
A
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V
L
--
R
L
A
D
G
P
D
E
V
H
L
S
A
I
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
84.99
37%
-2
- C2 -
-
4HR3
1
?
A:
[7-413]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
P
S
A
R
A
A
E
L
I
A
A
V
R
E
F
I
D
A
E
V
M
P
V
E
R
A
V
L
A
H
------
H
D
E
L
L
G
A
R
A
G
-
T
T
A
E
L
--
W
H
V
P
P
E
L
D
S
L
K
A
K
A
-
R
A
A
G
L
W
N
L
F
L
P
D
P
E
L
G
G
G
L
S
N
---
S
E
-
Y
A
P
L
A
E
Q
M
-------
G
-------
R
S
L
F
-
A
P
T
V
-
F
N
C
-
N
A
P
D
S
G
N
M
E
V
L
H
R
Y
G
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Q
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Q
K
E
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W
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L
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G
D
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A
F
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M
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D
V
A
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A
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N
M
A
A
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A
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--
E
G
D
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--
V
V
I
N
G
R
K
W
W
S
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--
V
--
G
H
--
P
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C
KV
I
I
F
M
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L
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A
-
H
R
Y
A
R
H
---
S
M
V
L
V
P
M
D
---------
T
P
G
I
T
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M
L
P
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M
G
F
Y
D
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P
-
G
-
G
------------
H
G
V
V
S
F
D
N
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R
L
P
A
D
A
F
I
A
-
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K
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F
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P
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A
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E
H
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G
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A
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N
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T
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L
L
V
L
H
A
A
--------
W
L
L
D
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------
G
I
-----------------
M
G
A
-
L
-----
S
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---
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S
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V
A
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L
A
K
Y
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
83.77
34%
-23
- C2 -
-
2WBI
2
ACD11_HUMAN
B:
[22-424]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
T
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-------
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------
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-----------------
A
G
A
-
K
-----
K
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---
I
A
M
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A
A
P
R
A
V
S
K
I
V
D
W
A
I
Q
V
C
G
G
A
G
V
S
Q
D
Y
P
L
A
N
M
Y
A
I
T
R
V
L
--
R
L
A
D
G
P
D
E
V
H
L
S
A
I
A
T
M
E
L
R
D
Q
A
K
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.93
38%
19
- C2 -
-
4HR3
1
?
A:
[10-407]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
R
A
A
E
L
I
A
A
V
R
E
F
I
D
A
E
V
M
P
V
E
R
A
V
L
A
H
H
D
E
L
L
G
A
R
------
A
G
-
T
T
A
E
L
--
W
H
V
P
P
E
L
D
S
L
K
A
K
A
-
R
A
A
G
L
W
N
L
F
L
P
D
P
E
L
G
G
G
L
S
N
---
S
E
-
Y
A
P
L
A
E
Q
M
-------
G
-------
R
S
-
L
-
F
A
P
T
V
F
N
C
-
N
A
P
D
S
G
N
M
E
V
L
H
R
Y
G
S
Q
E
Q
K
E
V
W
L
E
P
L
L
E
G
D
I
R
S
A
F
C
M
T
E
P
D
V
A
S
S
D
A
T
-
N
M
A
A
T
A
V
V
--
E
G
D
E
--
V
V
I
N
G
R
K
W
W
S
T
G
--
V
GH
P
D
C
K
V
I
----
I
F
M
G
L
T
D
P
N
-
A
H
R
Y
A
R
H
---
S
M
V
L
V
P
M
D
---------
T
P
G
I
T
V
E
R
M
L
P
T
M
G
F
Y
D
E
P
-
G
-
G
------------
H
G
V
V
S
F
D
N
V
R
L
P
A
D
A
F
I
A
-
G
P
G
K
G
F
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I
A
Q
G
R
L
G
P
G
R
V
H
H
A
M
R
L
I
G
L
A
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V
A
L
E
H
A
C
R
R
G
L
D
R
T
A
F
G
K
P
L
V
N
L
G
G
N
R
E
R
I
A
D
A
R
I
A
I
N
Q
T
R
L
L
V
L
H
A
A
--------
W
L
L
D
T
V
------
G
I
-------------------
M
G
A
L
----
S
A
---
V
S
E
I
K
V
A
A
P
N
M
A
Q
Q
V
I
D
M
A
I
Q
I
H
G
G
G
G
L
S
N
D
F
P
L
A
A
A
W
V
N
A
R
A
L
--
R
L
A
D
G
P
D
E
V
H
R
G
V
V
A
R
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
80.52
22%
-40
- C2 -
-
2Z1Q
2
?
B:
[5-577]
---------------------------------------------------------------------------------------------------------------------
K
K
L
W
Q
K
----
G
G
G
W
L
L
E
V
P
E
R
-------------------------------------------------------------------------------
V
Y
T
P
E
D
F
---------------------------------------------------------------------------------------------------------------------------------------------
D
E
S
V
K
E
I
A
R
T
T
R
T
F
V
E
R
E
V
L
P
L
L
E
R
M
------------------------
E
--
H
G
E
L
E
L
N
V
P
L
M
R
K
A
-
G
E
L
G
L
L
A
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D
V
P
E
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Y
G
G
L
D
L
P
K
---
V
I
-
S
T
V
V
A
E
E
L
-------
S
-------
G
S
-
G
-
G
F
S
V
T
Y
G
A
-
H
T
S
I
G
--
T
L
P
L
V
Y
F
G
T
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Q
K
R
K
Y
L
P
K
L
A
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G
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W
I
A
A
Y
C
L
T
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G
S
G
S
D
A
L
A
A
K
T
R
A
T
L
S
E
--
D
G
K
H
--
Y
I
L
N
G
V
K
Q
W
I
S
N
--
A
--
G
--
F
A
H
L
--
F
T
V
F
A
K
V
D
G
E
------
H
F
---
T
A
F
L
V
E
R
D
---------
T
P
G
L
S
F
G
P
E
E
K
K
M
G
I
K
--
A
-
S
-
S
------------
T
R
Q
V
I
L
E
D
V
K
V
P
V
E
N
V
L
G
-
E
I
G
K
G
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
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L
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A
Q
Y
A
T
Q
R
V
Q
F
G
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P
I
G
R
F
G
L
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Q
K
L
G
E
M
A
S
R
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Y
A
A
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S
A
V
Y
R
T
V
--------
G
L
I
D
E
A
L
LGKKG
P
E
-----------------
A
V
M
A
G
I
E
E
Y
A
V
E
---
A
S
I
I
K
V
L
G
S
E
V
L
D
Y
V
V
D
E
G
V
Q
I
H
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
A
R
I
N
--
R
I
F
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G
T
N
E
I
N
R
L
L
I
P
G
M
L
L
R
R
A
E
P
E
D
L
E
L
H
Q
V
Q
N
L
K
K
L
A
L
M
V
A
G
L
A
V
Q
K
YGQGVEEE
Q
E
V
L
G
A
V
A
D
I
L
I
D
A
Y
A
A
E
S
A
L
L
R
A
R
R
L
GGL
A
P
V
L
A
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I
Y
L
A
Q
A
L
D
R
A
Q
A
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A
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S
V
LPRLVEG
D
E
A
R
V
V
Y
S
A
A
R
R
L
T
KREPGD
L
V
A
L
R
R
Q
A
A
E
A
V
L
E
A
GGYPIPR------------------
47
Fugue
78.32
19%
-25
- C2 -
-
2UXW
4
ACADV_HUMAN
A:
[21-607]
------------------------------------------------------------------------------------------------
Q
S
M
S
F
A
V
G
M
F
K
G
Q
L
T
T
D
Q
V
F
P
Y
P
S
V
L
N
E
E
Q
T
Q
F
L
K
E
L
V
E
P
V
S
R
F
F
E
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
D
P
A
K
N
D
A
------
L
E
------
M
V
-
E
-------------
E
T
T
W
Q
G
L
-
K
E
L
G
A
F
G
L
Q
V
P
S
E
L
G
G
V
G
L
C
N
---
T
Q
-
Y
A
R
L
V
E
I
V
-------
G
-------
M
H
-
D
-
L
G
V
G
I
T
L
G
-
A
H
Q
S
I
G
-
F
K
G
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L
L
F
G
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K
A
Q
K
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K
Y
L
P
K
L
A
S
G
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V
A
A
F
C
L
T
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P
S
S
G
S
D
A
A
S
I
R
T
S
A
V
P
S
P
--
C
G
K
Y
--
Y
T
L
N
G
S
K
L
W
I
S
N
--
G
--
G
L
A
D
I
F
T
--
V
F
A
K
T
P
V
T
D
P
A
T
G
A
V
K
E
K
I
--
T
A
F
V
V
E
R
G
---------
F
G
G
I
T
H
G
P
P
E
K
K
M
G
I
K
A
S
N
----------------
T
A
E
V
F
F
D
G
V
R
V
P
S
E
N
V
L
G
-
E
V
G
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G
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
E
K
I
H
N
F
G
L
I
Q
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K
L
A
R
M
V
M
L
Q
Y
V
T
E
S
M
A
Y
M
V
S
--------
A
N
M
D
Q
G
------
A
T
-----------------
D
F
---
Q
----
I
E
---
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
--
R
I
F
E
G
T
N
D
I
L
R
L
F
V
A
L
Q
G
C
M
D
K
G
K
E
L
S
G
L
G
S
A
L
K
N
P
F
G
SGLSLSGLVHPEL
S
R
S
G
E
L
A
V
R
A
L
E
Q
F
A
T
V
V
E
A
K
L
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K
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Q
F
L
L
Q
R
L
A
D
G
A
I
D
L
Y
A
M
V
V
V
L
S
R
A
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R
S
L
S
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GHPT
A
Q
H
E
K
M
L
C
D
T
W
C
I
E
A
A
A
R
I
R
E
G
M
A
A
L
Q
SDPW
Q
Q
E
L
Y
R
N
F
K
S
I
S
K
A
L
V
E
R
GGVVTSNPLGF
52
SP3
76.91
10%
-83
- C2 -
-
3MDD
2
ACADM_PIG
A:
[1-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
F
E
L
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
T
-------
G
------
E
Y
-
P
-------------
V
P
L
L
K
R
A
-
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
G
I
---
I
D
-
S
C
L
I
T
E
E
L
-------
A
-------
Y
G
-
C
---
T
G
V
Q
T
A
-
I
E
A
N
T
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
-
A
G
S
D
V
A
-
G
I
K
T
K
A
E
K
--
K
G
D
E
--
Y
I
I
N
G
Q
K
M
W
I
T
N
--
G
--
G
K
A
N
W
Y
F
--
L
L
A
R
S
D
P
D
P
K
A
P
-
A
S
K
A
F
---
T
G
F
I
V
E
A
D
---------
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
---
S
-
D
------------
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
-
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
--------
W
E
I
D
S
G
------
R
R
-----------------
N
----
T
----
Y
Y
---
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
--
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
H
I
G
R
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
50
SP3
74.98
10%
-96
* C2 *
-
1RX0
8
ACAD8_HUMAN
A:
[10-393]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
C
I
D
P
S
M
G
L
N
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
Q
-------
K
E
------
L
F
-
P
-------------
V
D
V
M
R
K
A
-
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
S
R
---
L
D
-
T
S
V
I
F
E
A
L
-------
A
-------
T
G
-
C
---
T
S
T
T
A
Y
-
I
S
I
H
N
M
C
A
W
M
I
D
S
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
M
E
K
F
A
S
Y
C
L
T
E
P
G
-
S
G
S
D
A
A
-
S
L
L
T
S
A
K
K
--
Q
G
D
H
--
Y
I
L
N
G
S
K
A
F
I
S
G
--
A
--
G
E
S
D
I
Y
V
--
V
M
C
R
T
-----
G
G
P
G
P
K
G
I
---
S
C
I
V
V
E
K
G
---------
T
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
---
Q
-
P
------------
T
R
A
V
I
F
E
D
C
A
V
P
V
A
N
R
I
G
-
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
R
N
A
A
--------
V
A
L
Q
E
E
------
R
K
-----------------
D
---
A
V
----
A
L
---
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
--
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
R
S
L
L
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
54
SP3
74.81
9%
-95
- C2 -
-
1IVH
5
IVD_HUMAN
A:
[6-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
A
I
N
G
L
S
E
E
Q
R
Q
L
R
Q
T
M
A
K
F
L
Q
E
H
L
A
P
K
A
Q
E
I
D
R
S
-------------------------
N
E
F
K
N
L
R
E
F
W
K
Q
L
-
G
N
L
G
V
L
G
I
T
A
P
V
Q
Y
G
G
S
G
L
G
Y
---
L
E
-
H
V
L
V
M
E
E
I
-------
S
-------
R
A
-
S
--
G
A
V
G
L
S
Y
-
G
A
H
S
N
L
C
I
N
Q
L
V
R
N
G
N
E
A
Q
K
E
K
Y
L
P
K
L
I
S
G
E
Y
I
G
A
L
A
M
S
E
P
N
-
A
G
S
D
V
V
-
S
M
K
L
K
A
E
K
--
K
G
N
H
--
Y
I
L
N
G
N
K
F
W
I
T
N
--
G
--
P
D
A
D
V
L
I
--
V
Y
A
K
--
T
D
L
A
A
V
P
A
S
R
G
I
---
T
A
F
I
V
E
K
G
---------
M
P
G
F
S
T
S
K
K
L
D
K
L
G
M
R
--
G
-
S
-
N
------------
T
C
E
L
I
F
E
D
C
K
I
P
A
A
N
I
L
G
-
H
E
N
K
G
V
Y
V
L
M
S
G
L
D
L
E
R
L
V
L
A
G
G
P
L
G
L
M
Q
A
V
L
D
H
T
I
P
Y
L
H
V
R
E
A
F
G
Q
K
I
G
H
F
Q
L
M
Q
G
K
M
A
D
M
Y
T
R
L
M
A
C
R
Q
Y
V
Y
N
V
A
--------
K
A
C
D
E
G
------
H
C
-----------------
T
----
A
----
K
D
---
C
A
G
V
I
L
Y
S
A
E
C
A
T
Q
V
A
L
D
G
I
Q
C
F
G
G
N
G
Y
I
N
D
F
P
M
G
R
F
L
R
D
A
K
L
Y
--
E
I
G
A
G
T
S
E
V
R
R
L
V
I
G
R
A
F
N
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
53
SP3
74.08
11%
-90
- C2 -
-
1JQI
4
ACADS_RAT
A:
[4-387]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
Q
S
V
E
L
P
E
T
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
E
-------
H
------
L
F
-
P
-------------
T
S
Q
V
K
K
M
-
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
D
Y
---
L
A
-
Y
S
I
A
L
E
E
I
-------
S
-------
R
G
-
C
-
A
S
T
G
V
I
M
S
-
V
N
N
-
S
L
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
-
N
G
S
D
A
G
-
A
A
S
T
T
A
R
E
--
E
G
D
S
--
W
V
L
N
G
T
K
A
W
I
T
N
--
S
--
W
E
A
S
A
T
V
--
V
F
A
S
----
T
D
R
S
R
Q
N
K
G
I
---
S
A
F
L
V
P
M
P
---------
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
--
A
-
S
-
S
------------
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
-
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
--------
M
L
K
D
N
K
------
K
P
---------------------
F
T
----
K
E
---
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
--
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
R
S
Y
R
----------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
73.36
21%
-34
- C2 -
-
1RX0
12
ACAD8_HUMAN
D:
[12-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
I
D
P
S
M
G
L
N
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
Q
K
------
E
---------------------
L
F
P
V
D
V
M
R
K
A
-
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
S
R
---
L
D
-
T
S
V
I
F
E
A
L
-------
A
-------
T
G
C
T
S
T
T
-
A
Y
I
----
S
I
H
N
M
C
A
W
M
I
D
S
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
M
E
K
F
A
S
Y
C
L
T
E
P
G
-
S
G
S
D
A
A
-
S
L
L
T
S
A
K
K
--
Q
G
D
H
--
Y
I
L
N
G
S
K
A
F
I
S
G
--
A
--
G
E
--
S
D
I
--
Y
V
V
M
C
R
T
G
G
P
---
G
P
K
G
I
---
S
C
I
V
V
E
K
G
---------
T
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
---
Q
-
P
------------
T
R
A
V
I
F
E
D
C
A
V
P
V
A
N
R
I
G
-
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
R
N
A
A
--------
V
A
L
Q
E
E
------
R
K
------------------
D
A
-
V
-----
A
L
---
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
--
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
R
S
L
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
72.89
26%
-33
- C2 -
-
1UKW
2
?
A:
[17-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
-
Y
D
E
------
K
E
------
E
V
-
P
W
-------
P
V
I
E
------
K
L
-
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
G
L
K
M
---
L
D
-
E
V
I
V
G
E
---------
E
-------
L
A
-
Y
-
A
C
M
G
I
Y
T
I
P
M
A
S
D
L
G
I
T
P
V
L
L
A
-
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
-
N
G
S
D
A
A
-
A
L
K
T
R
A
I
R
--
Q
G
D
H
--
Y
V
L
N
G
T
K
M
W
I
S
N
--
G
--
G
E
--
A
E
W
--
V
V
V
F
A
T
V
N
P
E
L
R
H
--
K
G
V
---
V
A
L
V
V
E
R
G
---------
T
P
G
F
K
A
I
K
I
H
G
K
M
G
--
Q
R
A
-
S
-
G
------------
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
-
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
--------
W
L
A
D
Q
-------
G
L
-----------------
P
H
A
H
-------
A
---
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
--
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
72.76
19%
-30
- C2 -
-
2IX5
5
ACOX4_ARATH
B:
[45-431]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
D
Y
Y
H
F
N
D
L
L
T
P
E
E
Q
A
I
R
K
K
V
R
E
C
M
E
K
E
V
A
P
I
M
T
E
Y
W
E
K
------
A
---------------------
E
F
P
F
H
I
T
P
K
L
-
G
A
M
G
V
A
G
G
S
I
-
K
G
Y
G
C
P
G
L
S
I
---
T
A
-
N
A
I
A
T
A
E
I
-------
A
-------
R
V
D
A
S
C
S
-
T
F
I
L
V
-
H
--
S
S
L
G
M
L
T
I
A
L
C
G
S
E
A
Q
K
E
K
Y
L
P
S
L
A
Q
L
N
T
V
A
C
W
A
L
T
E
P
D
-
N
G
S
D
A
S
-
G
L
G
T
T
A
T
K
--
V
E
G
G
--
W
K
I
N
G
Q
K
R
W
I
G
N
--
S
--
T
F
--
A
D
L
--
L
I
I
F
A
R
N
T
T
T
-----
N
Q
I
---
N
G
F
I
V
K
K
D
---------
A
P
G
L
K
A
T
K
I
P
N
K
I
G
L
R
M
---
V
-
Q
------------
N
G
D
I
L
L
Q
N
V
F
V
P
D
E
D
R
L
P
-
G
V
N
-
S
F
Q
D
T
S
K
V
L
A
V
S
R
V
M
V
A
W
Q
P
I
G
I
S
M
G
I
Y
D
M
C
H
R
Y
L
K
E
R
K
Q
F
G
A
P
L
A
A
F
Q
L
N
Q
Q
K
L
V
Q
M
L
G
N
V
Q
A
M
F
L
M
G
W
R
L
C
--------
K
L
Y
E
T
G
------
Q
------------------
M
T
--
P
-----
G
Q
---
A
S
L
G
K
A
W
I
S
S
K
A
R
E
T
A
S
L
G
R
E
L
L
G
G
N
G
I
L
A
D
F
L
V
A
K
A
F
C
D
L
E
P
I
--
Y
T
Y
E
G
T
Y
D
I
N
T
L
V
T
G
R
E
V
T
G
I
A
S
F
K
P
A
------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
72.23
20%
-24
- C2 -
-
3MDD
2
ACADM_PIG
A:
[1-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
F
E
L
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
T
-------------------------
G
E
Y
P
--
V
P
L
L
K
R
A
-
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
---LG
I
I
D
-
S
C
L
I
T
E
E
L
-------
A
-------
Y
G
-
C
-
T
G
V
Q
T
A
I
E
-
A
N
T
-
L
G
-
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
-
I
K
T
K
A
E
K
K
--
G
-
D
E
--
Y
I
I
N
G
Q
K
M
W
I
T
N
--
G
--
G
K
A
N
W
Y
F
--
L
L
A
R
S
D
P
D
P
K
-
A
P
A
S
K
A
F
---
T
G
F
I
V
E
A
D
---------
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
----------------
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
-
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
--------
W
E
I
D
S
---------------------------
G
R
R
N
T
----
Y
Y
---
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
--
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
H
I
G
R
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
74
HHSearch
71.29
23%
-22
- C2 -
-
2JIF
6
ACDSB_HUMAN
A:
[24-403]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
L
Q
T
F
T
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
E
N
------
S
---------------------
K
M
E
K
S
V
I
Q
G
L
-
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
S
F
---
L
S
-
T
V
L
V
I
E
E
L
-------
A
-------
K
V
D
A
S
V
A
-
V
F
C
E
---
I
Q
N
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
-
E
K
V
G
S
F
C
L
S
E
A
G
-
A
G
S
D
S
F
-
A
L
K
T
R
A
D
K
--
E
G
D
Y
--
Y
V
L
N
G
S
K
M
W
I
S
S
--
A
--
E
H
--
A
G
L
--
F
L
V
M
A
N
V
D
P
T
--
I
G
Y
K
G
I
---
T
S
F
L
V
D
R
D
---------
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
---
S
-
S
------------
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
-
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
--------
R
L
L
E
A
G
------
K
-------------------
P
F
-
I
-----
K
E
---
A
S
M
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
--
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
D
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
78
HHSearch
71.23
20%
-25
- C2 -
-
1IVH
5
IVD_HUMAN
A:
[6-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
A
I
N
G
L
S
E
E
Q
R
Q
L
R
Q
T
M
A
K
F
L
Q
E
H
L
A
P
K
A
Q
E
I
D
R
S
------
N
E
-------------------
F
K
N
L
R
E
F
W
K
Q
L
-
G
N
L
G
V
L
G
I
T
A
P
V
Q
Y
G
G
S
G
L
G
Y
---
L
E
-
H
V
L
V
M
E
E
I
-------
S
-------
R
A
S
G
A
V
G
-
L
S
Y
G
A
-
H
--
S
N
L
C
I
N
Q
L
V
R
N
G
N
E
A
Q
K
E
K
Y
L
P
K
L
I
S
G
E
Y
I
G
A
L
A
M
S
E
P
N
-
A
G
S
D
V
V
-
S
M
K
L
K
A
E
K
--
K
G
N
H
--
Y
I
L
N
G
N
K
F
W
I
T
N
--
G
--
P
D
--
A
D
V
--
L
I
V
Y
A
K
T
D
L
A
A
V
P
A
S
R
G
I
---
T
A
F
I
V
E
K
G
---------
M
P
G
F
S
T
S
K
K
L
D
K
L
G
M
R
G
---
S
-
N
------------
T
C
E
L
I
F
E
D
C
K
I
P
A
A
N
I
L
G
-
H
E
N
K
G
V
Y
V
L
M
S
G
L
D
L
E
R
L
V
L
A
G
G
P
L
G
L
M
Q
A
V
L
D
H
T
I
P
Y
L
H
V
R
E
A
F
G
Q
K
I
G
H
F
Q
L
M
Q
G
K
M
A
D
M
Y
T
R
L
M
A
C
R
Q
Y
V
Y
N
V
A
--------
K
A
C
D
E
G
------
H
------------------
C
T
--
A
-----
K
D
---
C
A
G
V
I
L
Y
S
A
E
C
A
T
Q
V
A
L
D
G
I
Q
C
F
G
G
N
G
Y
I
N
D
F
P
M
G
R
F
L
R
D
A
K
L
Y
--
E
I
G
A
G
T
S
E
V
R
R
L
V
I
G
R
A
F
N
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
71.22
24%
0
- C- -
-
3B96
2
ACADV_HUMAN
A:
[33-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
K
E
L
V
E
P
V
S
R
F
F
E
E
----------------
V
-
N
D
P
A
K
--
N
D
A
L
E
M
V
E
E
T
T
W
Q
G
L
K
E
L
G
A
F
G
L
Q
V
P
S
E
L
G
G
V
G
L
C
N
---
T
Q
-
Y
A
R
L
V
E
I
V
-------
G
-------
M
H
-
D
-
L
G
V
G
I
-
T
L
-
G
A
H
Q
S
I
G
F
K
G
I
L
L
F
G
T
K
A
Q
K
E
K
Y
L
P
K
L
A
S
G
E
T
V
A
A
F
C
L
T
E
P
S
-
S
G
S
D
A
A
-
S
I
R
T
S
A
V
P
--
S
P
C
G
K
Y
Y
T
L
N
G
S
K
L
W
I
S
N
--
G
GL
A
D
I
F
T
V
F
--
A
----------
K
T
P
V
T
D
P
---
A
T
G
A
V
--------------
K
E
K
I
T
A
F
V
V
E
R
G
F
G
G
I
T
-
H
-
G
P
PEKKMGIKA
S
N
T
A
E
V
F
F
D
G
V
R
V
P
S
E
N
V
L
G
-
E
V
G
S
G
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
V
M
L
Q
Y
V
T
E
S
M
A
Y
M
V
S
--------
A
N
M
D
Q
-------
G
A
-----------------
T
D
F
Q
I
E
----
A
A
---
I
S
--
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
--
R
I
F
E
G
T
N
D
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
HHSearch
71.03
19%
-28
- C2 -
-
3SWO
6
?
C:
[16-397]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
E
L
F
D
T
D
R
L
L
D
Q
D
E
R
D
I
A
A
T
V
R
Q
F
V
D
T
R
L
K
P
N
V
E
G
W
F
E
S
---------------------------
A
T
L
P
S
E
L
A
K
E
F
-
G
N
L
G
V
L
G
M
H
L
Q
-
G
Y
G
C
A
G
T
N
A
---
V
S
-
Y
G
L
A
C
M
E
L
-------
E
-------
A
G
D
S
G
F
R
S
F
-
V
S
V
-
Q
--
G
S
L
S
M
F
S
I
Y
R
Y
G
S
E
E
Q
K
N
E
W
L
P
R
L
A
A
G
D
A
I
G
C
F
G
L
T
E
P
D
-
F
G
S
N
P
A
-
G
M
R
T
R
A
R
R
--
D
G
S
D
--
W
I
L
N
G
T
K
M
W
I
T
N
--
G
--
N
L
--
A
D
V
--
A
T
V
W
A
Q
T
D
D
-------
G
I
---
R
G
F
L
V
P
T
D
---------
T
P
G
F
T
A
N
E
I
H
R
K
L
S
L
R
A
---
S
-
V
------------
T
S
E
L
V
L
D
N
V
R
L
P
A
S
A
Q
L
P
--
L
A
E
G
L
S
A
P
L
S
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
S
L
E
T
T
I
A
Y
T
Q
S
R
E
V
F
D
K
P
L
S
N
Y
Q
L
T
Q
E
K
L
A
N
M
T
V
E
L
G
K
G
M
L
L
A
I
H
L
G
--------
R
I
K
D
A
E
------
G
------------------
V
R
P
-------
E
Q
---
I
S
L
G
K
L
N
N
V
R
E
A
I
A
I
A
R
E
C
R
T
L
L
G
G
S
G
I
T
L
E
Y
S
P
L
R
H
A
N
N
L
E
S
V
--
L
T
Y
E
G
T
S
E
M
H
L
L
S
I
G
K
A
L
T
G
K
A
A
F
---------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
70.88
21%
-28
- C2 -
-
3OWA
6
?
C:
[26-429]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
F
T
P
E
D
F
S
S
E
H
K
M
I
A
K
T
T
E
D
F
I
V
N
E
V
L
P
E
L
E
Y
L
E
Q
H
------
E
-----------------
F
---
D
R
S
V
R
L
L
K
E
A
-
G
E
L
G
L
L
G
A
D
V
P
E
E
Y
G
G
I
G
L
D
K
---
V
S
-
S
A
L
I
A
E
K
F
-------
S
-------
R
A
-
G
G
F
A
I
-
T
H
G
A
-
H
--
V
G
I
G
S
L
P
I
V
L
F
G
N
E
E
Q
K
K
K
Y
L
P
L
L
A
T
G
E
K
L
A
A
Y
A
L
T
E
P
G
-
S
G
S
D
A
L
-
G
A
K
T
T
A
R
L
N
A
E
G
T
H
--
Y
V
L
N
G
E
K
Q
W
I
T
N
--
S
--
A
F
--
A
D
V
--
F
I
V
Y
A
K
I
D
G
------
E
H
F
---
S
A
F
I
V
E
K
D
---------
Y
A
G
V
S
T
S
P
E
E
K
K
M
G
I
K
C
---
S
-
S
------------
T
R
T
L
I
L
E
D
A
L
V
P
K
E
N
L
L
G
-
E
I
G
K
G
H
I
I
A
F
N
I
L
N
I
G
R
Y
K
L
G
V
G
T
V
G
S
A
K
R
A
V
E
I
S
A
Q
Y
A
N
Q
R
Q
Q
F
K
Q
P
I
A
R
F
P
L
I
Q
E
K
L
A
N
M
A
A
K
T
Y
A
A
E
S
S
V
Y
R
T
V
--------
G
L
F
E
S
R
------
M
S
TLS
E
E
E
V
K
D
G
K
A
V
A
A
S
I
A
E
Y
-
A
-----
I
E
---
C
S
L
N
K
V
F
G
S
E
V
L
D
Y
T
V
D
E
G
V
Q
I
H
G
G
Y
G
F
M
A
E
Y
E
I
E
R
M
Y
R
D
S
R
I
N
--
R
I
F
E
G
T
N
E
I
N
R
L
I
V
P
G
T
F
L
R
K
A
M
K
G
--------------------------------------------------------------------------------------------------------------------------------------------------------
80
HHSearch
70.23
20%
-20
- C2 -
-
2PG0
2
?
B:
[8-383]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
L
R
E
E
H
H
M
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
R
------
G
---------------------
I
I
P
R
S
F
W
A
K
M
-
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
D
F
---
A
Y
-
S
V
V
I
N
E
E
L
-------
E
-------
K
V
G
S
S
L
V
----
G
I
-
G
L
H
N
D
I
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
-
A
G
S
D
L
A
-
N
I
S
T
T
A
V
K
--
D
G
D
Y
--
Y
I
V
N
G
Q
K
T
F
I
T
N
--
G
--
I
H
--
A
D
L
--
I
V
V
A
C
K
T
D
P
Q
A
K
P
P
H
R
G
I
---
S
L
L
V
V
E
R
D
---------
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
---
Q
-
D
------------
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
-
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
--------
E
E
H
M
A
G
------
K
-------------------
Q
I
-
V
-----
T
E
---
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
--
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
69
HHSearch
69.97
19%
-24
- C2 -
-
6ES9
3
?
A:
[165-551]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
D
E
D
L
E
M
I
R
D
Q
F
R
R
Y
A
E
E
R
V
I
P
N
A
H
E
W
H
L
K
------
D
--------------------
Q
L
I
P
M
E
I
I
E
E
L
-
A
E
L
G
V
F
G
L
T
I
P
E
E
F
G
G
L
G
L
S
K
---
A
S
-
M
V
V
V
T
E
E
L
-------
S
-------
R
G
Y
I
G
V
G
-
S
L
G
----
T
R
S
E
I
A
A
E
L
I
L
C
G
G
T
E
A
Q
K
A
K
W
L
P
G
L
A
S
G
E
I
L
S
T
A
V
F
T
E
P
N
-
T
G
S
D
L
G
-
S
L
R
T
R
A
V
R
--
D
G
E
D
--
W
V
V
T
G
N
K
T
W
I
T
H
--
A
--
Q
R
--
T
H
V
--
M
T
L
L
A
R
T
D
P
E
T
-
T
D
W
R
G
L
---
S
M
F
L
A
E
K
E
P
G
T
DDDPFP
T
P
G
M
T
G
-
G
E
I
E
V
L
G
Y
R
G
---
M
-
K
------------
E
Y
E
L
G
F
D
G
F
R
I
K
G
E
N
L
L
G
G
E
P
G
R
G
F
K
Q
L
M
E
T
F
E
S
A
R
I
Q
T
A
A
R
A
V
G
V
A
Q
S
A
A
E
I
G
M
R
Y
A
V
D
R
K
Q
F
G
K
S
L
I
E
F
P
R
V
A
D
K
L
A
M
M
A
V
E
I
M
I
A
R
Q
L
T
Y
F
S
A
--------
W
E
K
D
H
G
------
R
R
------------------
C
--
D
-----
L
E
---
A
G
M
A
K
L
L
G
A
R
V
A
W
A
A
A
D
N
A
L
Q
I
H
G
G
N
G
F
A
L
E
Y
A
I
S
R
V
L
C
D
A
R
I
L
--
N
I
F
E
G
A
A
E
I
Q
A
Q
V
I
A
R
R
L
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
79
HHSearch
69.66
20%
-19
- C2 -
-
2PG0
2
?
A:
[6-383]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
R
Y
L
R
E
E
H
H
M
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
R
------
G
---------------------
I
I
P
R
S
F
W
A
K
M
-
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
D
F
---
A
Y
-
S
V
V
I
N
E
E
L
-------
E
-------
K
V
G
S
S
L
V
----
G
I
-
G
L
H
N
D
I
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
-
A
G
S
D
L
A
-
N
I
S
T
T
A
V
K
--
D
G
D
Y
--
Y
I
V
N
G
Q
K
T
F
I
T
N
--
G
--
I
H
--
A
D
L
--
I
V
V
A
C
K
T
D
P
Q
A
K
P
P
H
R
G
I
---
S
L
L
V
V
E
R
D
---------
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
---
Q
-
D
------------
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
-
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
--------
E
E
H
M
A
G
------
K
-------------------
Q
I
-
V
-----
T
E
---
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
--
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
73
HHSearch
69.57
23%
-29
- C2 -
-
6AF6
6
PIGA_SERS3
A:
[1-383]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
F
N
L
S
N
S
Q
S
D
I
Y
E
S
A
Y
R
F
A
C
D
V
L
D
Q
D
A
Q
T
R
I
S
Q
---------------------------
K
I
L
S
T
E
L
W
K
K
A
-
A
A
Y
G
F
A
H
G
P
V
S
H
Q
F
G
G
S
E
L
G
A
---
L
D
-
T
A
L
M
I
E
A
L
-------
G
-------
K
G
S
R
D
I
G
-
L
S
F
S
L
-
C
A
H
L
C
A
C
V
I
P
L
Y
R
F
G
S
S
E
L
K
D
K
Y
L
E
S
L
V
T
G
K
L
I
A
A
N
A
A
T
E
P
D
-
A
G
S
D
I
Y
-
N
M
Q
A
T
A
Q
P
--
C
E
G
G
--
Y
I
L
N
G
K
K
I
F
I
T
N
--
A
--
P
I
--
A
D
V
--
F
I
I
Y
A
K
T
N
P
D
--
H
G
F
L
G
V
---
S
A
F
L
I
E
K
G
---------
T
P
G
L
N
V
G
E
V
I
P
K
D
C
L
S
N
---
C
-
P
------------
W
S
E
I
V
F
N
D
I
F
I
P
Q
S
Q
R
I
G
-
M
E
G
A
G
G
A
I
F
H
D
S
M
I
W
A
K
G
C
L
S
A
L
F
V
G
G
L
A
R
L
L
E
T
T
L
E
Y
A
K
A
R
Q
Q
F
G
K
A
I
G
Q
F
Q
S
V
S
N
R
I
I
D
M
K
L
R
L
E
Q
C
R
L
M
L
Y
R
A
C
--------
W
K
H
D
Q
G
------
Q
-------------------
D
A
-
E
-----
A
D
---
I
A
M
S
K
L
L
I
S
E
Y
A
V
Q
S
G
L
D
A
I
Q
T
F
G
G
A
A
M
D
Q
E
L
G
L
V
R
H
L
L
N
M
I
P
S
--
R
I
F
S
G
T
N
D
I
Q
K
E
I
I
A
R
K
L
G
L
R
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
68.56
24%
-13
- C2 -
-
4IV6
2
?
A:
[18-378]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
D
F
V
E
K
Q
V
K
P
V
V
R
E
-
L
E
H
------
A
N
------
T
Y
-
P
-------------
E
E
L
I
E
T
M
-
K
E
I
G
I
F
G
L
A
I
P
E
P
-
Y
G
F
G
A
V
S
---
M
P
C
Y
V
Q
V
A
E
E
L
-------
A
-------
R
G
-
W
-
M
S
--
L
A
G
A
-
M
G
G
H
T
V
V
S
K
L
L
L
L
F
G
T
E
E
Q
K
Q
K
Y
L
P
R
M
A
T
G
E
L
R
A
T
M
A
L
T
E
P
G
-
G
G
S
D
L
Q
-
A
M
R
T
V
A
R
R
--
D
G
D
D
--
Y
V
I
N
G
S
K
T
W
I
S
N
--
A
----
R
R
S
D
L
--
V
A
L
M
C
K
T
D
P
D
A
Q
P
A
H
K
G
V
---
S
I
L
L
V
E
-
K
---------
V
P
G
F
D
V
S
R
D
L
P
K
L
G
Y
K
G
V
E
-
S
---------------
C
E
L
N
F
T
D
A
R
V
P
V
S
S
L
L
G
D
D
E
G
R
G
F
A
Q
M
M
K
G
L
E
V
G
R
L
Q
V
A
A
R
A
T
G
V
A
R
A
A
F
E
D
A
L
R
Y
S
Q
E
R
E
S
F
G
K
P
I
W
Q
H
Q
S
V
G
N
M
L
A
D
M
G
T
K
L
Y
A
A
R
S
L
L
L
S
A
A
--------
E
K
F
D
A
G
------
Q
R
-----------------
C
D
M
E
A
G
----
M
A
-------
K
L
F
A
S
E
T
A
M
Q
I
A
L
D
A
V
R
V
H
G
G
Y
G
Y
S
T
E
Y
D
V
E
R
Y
F
R
D
A
P
L
M
--
I
V
G
E
G
T
N
E
I
Q
R
N
V
I
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
65.91
24%
-12
- C2 -
-
2UXW
3
ACADV_HUMAN
A:
[53-439]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
K
E
L
V
E
P
V
S
R
F
F
E
E
----------------
V
-
N
D
P
A
K
--
N
D
A
L
E
M
V
E
E
T
T
W
Q
G
L
K
E
L
G
A
F
G
L
Q
V
P
S
E
L
G
G
V
G
L
C
N
---
T
Q
-
Y
A
R
L
V
E
I
V
-------
G
-------
M
H
-
D
-
L
G
V
G
I
-
T
L
-
G
A
H
Q
S
I
G
F
K
G
I
L
L
F
G
T
K
A
Q
K
E
K
Y
L
P
K
L
A
S
G
E
T
V
A
A
F
C
L
T
E
P
S
-
S
G
S
D
A
A
-
S
I
R
T
S
A
V
P
--
S
P
C
G
K
Y
Y
T
L
N
G
S
K
L
W
I
S
N
--
G
GL
A
D
I
F
T
V
F
--
A
----------
K
T
P
V
T
D
P
---
A
T
G
A
V
--------------
K
E
K
I
T
A
F
V
V
E
R
G
F
G
G
I
T
-
H
-
G
P
PEKKMGIKA
S
N
T
A
E
V
F
F
D
G
V
R
V
P
S
E
N
V
L
G
-
E
V
G
S
G
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
V
M
L
Q
Y
V
T
E
S
M
A
Y
M
V
S
--------
A
N
M
D
Q
-------
G
A
-----------------
T
D
F
Q
I
E
----
A
A
---
I
S
--
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
--
R
I
F
E
G
T
N
D
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
64.72
27%
-102
- C2 -
-
2DVL
2
?
A:
[95-371]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
-
G
S
D
A
K
-
S
L
R
A
E
A
R
R
--
V
K
G
G
--
F
V
L
N
G
V
K
S
W
I
T
S
--
A
--
G
H
--
A
H
L
--
Y
V
V
M
A
R
T
E
K
G
I
S
A
----------
F
L
V
E
K
G
---------
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
-
H
A
A
-
H
--------------
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
-
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
--------
R
K
K
D
R
-------
G
E
-----------------
R
--
F
T
L
----
E
A
---
S
A
A
K
L
F
A
S
A
A
A
V
E
-
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
--
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
62.71
23%
-8
- C2 -
-
4L1F
4
?
A:
[31-375]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
D
K
A
H
I
W
D
R
K
L
I
D
K
M
-
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
D
V
---
L
S
-
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
T
G
-------
I
T
---
L
S
A
N
V
S
L
C
-
A
T
P
-------
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
-
G
T
D
A
S
-
A
Q
Q
T
T
A
V
L
--
K
G
D
K
--
Y
I
L
N
G
S
K
I
F
I
T
N
--
G
KE
A
D
T
Y
V
V
F
--
A
M
T
------
D
K
S
Q
G
V
H
G
I
---
S
A
F
I
L
E
K
G
---------
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
-
T
---------------
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
-
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
--------
M
L
K
N
E
--------
G
-----------------
K
P
Y
S
E
A
----
A
A
---
M
A
K
C
F
A
--
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
--
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
58.85
26%
-18
- C2 -
-
6AF6
6
PIGA_SERS3
A:
[40-377]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
W
K
K
A
-
A
A
Y
G
F
A
H
G
P
V
S
H
Q
F
G
G
S
E
L
G
A
---
L
D
-
T
A
L
M
I
E
A
L
-------
G
K
G
S
RD
I
G
L
S
-
F
S
L
C
A
H
L
C
A
C
-
V
I
P
-------
L
Y
R
F
G
S
S
E
L
K
D
K
Y
L
E
S
L
V
T
G
K
L
I
A
A
N
A
A
T
E
P
D
A
-
G
S
D
I
Y
-
N
M
Q
A
T
A
Q
P
--
C
E
G
G
--
Y
I
L
N
G
K
K
I
F
I
T
N
--
A
--
P
I
A
D
V
F
----
I
I
Y
A
K
T
N
P
D
--
H
G
F
L
G
V
---
S
A
F
L
I
E
K
G
---------
T
P
G
L
N
V
G
E
V
I
P
K
D
C
L
S
N
C
P
----------------
W
S
E
I
V
F
N
D
I
F
I
P
Q
S
Q
R
I
G
-
M
E
G
A
G
G
A
I
F
H
D
S
M
I
W
A
K
G
C
L
S
A
L
F
V
G
G
L
A
R
L
L
E
T
T
L
E
Y
A
K
A
R
Q
Q
F
G
K
A
I
G
Q
F
Q
S
V
S
N
R
I
I
D
M
K
L
R
L
E
Q
C
R
L
M
L
Y
R
A
C
--------
W
K
H
D
Q
G
------
Q
D
-----------------
A
E
A
D
I
A
----
M
S
K
L
L
I
S
E
------
Y
A
V
Q
S
G
L
D
-
A
I
Q
T
F
G
--
G
A
A
M
D
Q
E
L
G
L
V
R
H
L
L
N
M
I
PS
R
I
F
S
G
T
N
D
I
Q
K
E
I
I
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
56.35
26%
-45
- C2 -
-
4N5F
2
?
A:
[106-383]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
G
R
V
I
G
A
F
C
L
T
E
P
H
A
-
G
S
E
A
N
-
N
L
R
T
R
A
E
L
--
R
D
G
Q
--
W
V
L
N
G
A
K
Q
F
V
T
N
--
G
----
Q
R
A
G
V
--
A
I
V
F
A
-----
M
T
D
P
E
A
G
K
RG
I
S
A
F
L
V
P
T
D
---------
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
--
A
-
S
-
D
------------
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
-
N
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
---------
K
L
R
T
A
------
G
--------------------
L
P
C
L
----
S
E
---
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
--
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
49.59
24%
-20
- C2 -
-
1BUC
3
ACDS_MEGEL
A:
[104-374]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
-
G
T
D
A
S
-
G
Q
Q
T
I
A
T
K
--
N
D
D
G
T
-
Y
T
L
N
G
S
K
I
F
I
T
N
GG
A
--
A
D
I
Y
I
V
F
--
A
M
T
------
D
K
S
K
G
N
H
G
I
---
T
A
F
I
L
E
D
G
---------
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
-
T
---------------
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
-
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
GKP
F
T
V
D
A
A
------
I
A
-----------------
K
R
V
A
S
D
----
V
A
---
M
R
------------
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
--
Q
I
Y
E
G
T
N
E
V
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------