@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : A6FXA8_9DELT: (2019-01-26 )
MHSRPQISPERAAQLAAEWFEGQLDAPAELDSYADRNFLVRAPDGTKAVLKVPNVELAEDIDLQIAILKWLEARPSAPLVPRVLGPTRTIEDDAGRPTRAWMVGWIEGELWFDASPTPALREELGAALGQLARDLEDFRHPGMERHFAWNLAEANWIAEELHRFEDPARAELVCDALMQFQGRVLPRLAELPTQVIHGDANDKNLAVAEGRLVGVFDFGDACWCPAVCDLAIALAYAAMDLRLGCALPEVAAACAQVCAGYHGRRPLTALELDLLYDLLRARLAVSVTSSTRAREAEPDNAYVSASEQGAWSVLEALGAVGRRAFTATVAEACGLALAPRVPGARTGDELLAARRRRLGPSLSLSYASSGMPLYIRRGEGSWLFDEHDQAFLDCVNNVCHVGHCHPRVVEAGAAQMARLNTNTRYLHEGLVDYAEALCATLPAPLEVVYLVNSGSEANELALRLARDYTGGFDVAVLDAAYHGNTGNLVDMSPYKFDAPGGRGRREWVHVLPTPDPYRGAHGDDGPAYAAALDAADAAARGRGSRLAALFCESVLGCAGQVVPASGFLAAAYARARAAGAVCIADEVQVGFGRVGDGMWAFEAEGVVPDILTLGKPIGNGHPLGAVVTTRAIAEALGGGRMEFFCTFGGNPVSAAVGAAVLAVIEDEGLVANARDTGSWLRGAFEQLAADPVLGRGIGEVRGRGLFIGVELVEDRSTKRPDAARASAIVAHARARGVLLSTDGPARNVIKIKPPICFADVEARILASTLARALSATMR
Atome Classification :
(60 SA)
.........10........20........30........40........50........60........70...-.....80........90........100.......110.......120.-......130.......140.......150.......160.......170.......180.......190...-....200......---.210.......220.......230.......240-------........250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350......----.360.......370.......380....---...390...--.--.----.--.--400.....---....410--------........---420----.---..--..------.----..430.--.......440..-.-...---------------..450.......460......------.------470----..------.----......480...---....---490--.-.--.---.....500--....----.--------..510----...--....------------.-.----520--.--..---..--.----.----.530---...-....540...-....550..-.-....560...-....570.......580.......590...--....600.......610.......620-....-....630.---....--.-.-------640---..----.......650.......660.....-..670.-......680..-.....690....--...700--.......710.....-----.-------.---720..-------------------.....730.......740--....--.-...750.......760.......770......-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MHSRPQI
S
P
E
R
A
A
Q
L
A
A
E
W
FEGQLDAP
A
E
L
D
SYADR
N
F
L
V
RAPDG
T
K
A
V
L
KVPNVE
L
A
E
DI
D
L
Q
I
A
I
L
K
W
L
E
AR-PSAPLVPRVLGPTRTIEDDAGR
P
T
R
A
W
M
V
G
W
IE
G
E
L
W
FDASP
T
P
A
L
R
E
E
-
L
G
A
A
L
G
Q
L
A
R
D
L
E
D
F
RHPGM
E
R
H
F
A
WNL
A
E
A
N
W
I
A
E
E
L
H
RFEDP
A
R
A
E
L
V
C
D
A
L
M
Q
F
Q
G
R
V
L
P
R
L
A
EL
P
T
Q
V
-IHGDANDK
N
L
A
V
A---E
G
R
L
V
G
V
F
DFGDACW
C
P
A
V
C
D
L
A
I
A
L
A
Y
A
A
M
D
L
--------RLGCA
L
P
E
V
A
A
A
C
A
Q
V
C
A
GYHGRRP
L
T
A
L
E
L
D
L
L
Y
D
L
L
R
A
R
L
A
V
S
VTSSTRAREAEPDN
A
Y
VSASEQ
G
A
W
S
V
L
E
A
L
G
A
VG
R
R
A
F
T
A
T
V
A
E
ACGLALAPRVPGART
G
D
E
L
L
A
A
R
R
R
RL----GPS
L
S
L
S
YASSG
M
P
L
Y
I
RRGEGSWLFDE---H
D
Q
A
F
L
D
C
V
--
N
--
N
----
V
--C--H--VGHC
H
---
P
R
V
V
E
A---------
G
A
A
Q
M
A
RL---N-T----
N
---
T
R
--
Y
L
------
H
----
E
G
L
V
-
D
--
Y
A
E
A
L
C
A
TL-PA-
P
-
L
E
V
---------------
V
Y
L
VNSGS
E
A
N
E
L
A
L
R
L
A
R
DY------T------G------G
F
------
D
----
V
A
V
L
D
A
A
YHGNT---G
N
L
V---DM---S-P--Y---KFDAPGGR--
G
R
R
E
----
W
--------
V
H
V------LPT--PDPY------------R-G----AH---G--DD---G
P
--
A
----
Y
----
A
A
A
L---DA
A
-
D
A
AARGRG
S
R
-
L
A
A
L
F
C
E
S
V
-
L
-GCAGQVVPAS-
G
F
L
A
A
A
Y
A
R
ARAA
G
A
V
C
I
ADE
V
Q
VGFGRVG--D
G
M
W
A
FEAEGVV
P
D
I
L
T
LGKPIGNG-H-P
L
G
A
-
V
V
T
T
R
A
I
A
---
E
A
LG--G-G-------
R
-----
M
E
----
F
F
C
T
FGG
N
P
V
S
A
A
V
G
A
A
V
L
A
V
IEDE-
G
L
V
ANA-RD
T
G
S
W
L
R
G
A
F
-
E
Q
LAAD
P
V
L
G
RG--
I
G
E
VRG--
R
G
L
F
I
G
V
E
L
VEDRST-----K-------R---P
D
A
A
R
-------------------
A
S
A
I
V
A
HARAR
G
V
L
L
S-T--DGPA--R-
N
V
I
K
IKPP
I
C
F
A
D
V
E
A
R
I
L
A
S
T
L
A
R
A
L
S
ATMR-
160
HHSearch
84.80
40%
-36
- C4 -
-
5G4J
2
?
A:
[18-439]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
A
R
R
Y
A
T
I
----
G
P
H
S
P
L
F
Y
R
---
Q
P
L
E
L
V
S
G
S
G
V
W
L
T
D
A
---
Q
G
K
V
Y
L
D
G
Y
--
N
--
N
----
V
--
P
--
H
--
V
G
H
A
N
---
P
A
V
A
D
A
---------
I
Y
Q
Q
L
L
T
V
---
N
-
L
----
H
---
T
R
--
Y
L
------
N
----
S
R
V
V
-
E
--
Y
A
E
A
L
L
S
K
F
-
D
G
-
A
-
L
E
R
---------------
L
F
L
T
N
S
G
S
E
A
N
E
L
A
L
R
I
A
R
Q
H
------
T
------
G
------
N
T
------
G
----
V
L
V
S
D
F
S
Y
H
G
N
T
---
T
S
L
A
---
E
I
---
T
-
T
--
G
---
L
T
V
H
E
-----
P
L
G
A
----
H
--------
V
R
A
------
L
R
I
--
P
D
V
S
------------
G
-
I
----
A
E
VD
V
P
--
V
L
---
L
E
--
Q
----
S
----
L
A
D
V
---
D
A
A
-
I
A
S
L
Q
A
A
G
H
G
-
V
S
V
F
L
F
D
P
L
-
F
-
S
T
E
G
L
L
Q
L
P
S
-
G
Y
I
E
G
V
A
T
R
V
R
A
A
G
G
L
V
I
S
D
E
V
Q
S
G
F
G
R
T
G
--
S
G
M
W
G
Y
Q
M
F
N
V
E
P
E
L
V
T
M
G
K
P
M
G
N
G
-
H
-
P
I
G
A
-
V
V
T
T
A
E
L
L
---
D
E
F
G
--
R
-
H
-------------
N
M
----
F
F
N
T
F
A
G
N
P
V
S
S
A
A
G
L
A
V
L
R
Y
M
D
Q
E
-
D
L
M
A
K
A
-
D
Q
L
G
K
Y
I
R
K
R
L
-
E
N
I
A
Q
R
---
S
G
N
--
V
G
S
V
R
G
--
R
G
L
F
F
G
I
D
I
I
E
S
D
G
S
-----
R
-------
N
---
P
A
P
A
L
-------------------
T
K
I
L
I
E
D
M
R
E
R
G
V
L
I
S
-
R
--
V
G
P
H
--
D
-
N
V
L
K
M
R
P
P
L
V
F
G
R
E
H
A
D
I
L
L
G
Q
L
E
L
S
L
A
S
L
P
--
159
HHSearch
84.25
40%
-36
- C4 -
-
5G4I
3
?
A:
[18-439]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
A
R
R
Y
A
T
I
----
G
P
H
S
P
L
F
Y
R
---
Q
P
L
E
L
V
S
G
S
G
V
W
L
T
D
A
---
Q
G
K
V
Y
L
D
G
Y
--
N
--
N
----
V
--
P
--
H
--
V
G
H
A
N
---
P
A
V
A
D
A
---------
I
Y
Q
Q
L
L
T
V
---
N
-
L
----
H
---
T
R
--
Y
L
------
N
----
S
R
V
V
-
E
--
Y
A
E
A
L
L
S
K
F
-
D
G
-
A
-
L
E
R
---------------
L
F
L
T
N
S
G
S
E
A
N
E
L
A
L
R
I
A
R
Q
H
------
T
------
G
------
N
T
------
G
----
V
L
V
S
D
F
S
Y
H
G
N
T
---
T
S
L
A
---
E
I
---
T
-
T
--
G
---
L
T
V
H
E
-----
P
L
G
A
----
H
--------
V
R
A
------
L
R
I
--
P
D
V
S
------------
G
-
I
----
A
E
VD
V
P
--
V
L
---
L
E
--
Q
----
S
----
L
A
D
V
---
D
A
A
-
I
A
S
L
Q
A
A
G
H
G
-
V
S
V
F
L
F
D
P
L
-
F
-
S
T
E
G
L
L
Q
L
P
S
-
G
Y
I
E
G
V
A
T
R
V
R
A
A
G
G
L
V
I
S
D
E
V
Q
S
G
F
G
R
T
G
--
S
G
M
W
G
Y
Q
M
F
N
V
E
P
E
L
V
T
M
G
K
P
M
G
N
G
-
H
-
P
I
G
A
-
V
V
T
T
A
E
L
L
---
D
E
F
G
--
R
-
H
-------------
N
M
----
F
F
N
T
F
A
G
N
P
V
S
S
A
A
G
L
A
V
L
R
Y
M
D
Q
E
-
D
L
M
A
K
A
-
D
Q
L
G
K
Y
I
R
K
R
L
-
E
N
I
A
Q
R
---
S
G
N
--
V
G
S
V
R
G
--
R
G
L
F
F
G
I
D
I
I
E
S
D
G
S
-----
R
-------
N
---
P
A
P
A
L
-------------------
T
K
I
L
I
E
D
M
R
E
R
G
V
L
I
S
-
R
--
V
G
P
H
--
D
-
N
V
L
K
M
R
P
P
L
V
F
G
R
E
H
A
D
I
L
L
G
Q
L
E
L
S
L
A
S
L
P
--
22
Blastp_CBE
81.90
41%
-17
- C4 -
-
5G4I
2
?
B:
[18-437]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
A
R
R
Y
A
T
I
----
G
P
H
S
P
L
F
Y
R
Q
---
P
L
E
L
V
S
G
S
G
V
W
L
T
D
A
---
Q
G
K
V
Y
L
D
G
Y
--
N
--
N
----
V
--
P
--
H
--
V
G
H
A
N
---
P
A
V
A
D
A
---------
I
Y
Q
Q
L
L
T
V
---
N
-
L
----
H
---
T
R
--
Y
L
------
N
----
S
R
V
V
-
E
--
Y
A
E
A
L
L
S
K
F
-
D
G
-
A
-
L
E
R
---------------
L
F
L
T
N
S
G
S
E
A
N
E
L
A
L
R
I
A
R
Q
H
------
T
------
G
------
N
T
------
G
----
V
L
V
S
D
F
S
Y
H
G
N
T
---
T
S
L
A
---
E
I
---
T
-
T
G-
L
---
T
V
H
E
P
L
G
------
A
----
H
--------
V
R
A
------
L
R
I
--
P
D
-
V
------------
S
-
G
----
I
A
---
E
--
V
D
---
V
P
--
V
----
L
LEQS
L
A
D
V
---
D
A
A
-
I
A
S
L
Q
A
A
G
H
G
-
V
S
V
F
L
F
D
P
L
-
F
-
S
T
E
G
L
L
Q
L
P
S
-
G
Y
I
E
G
V
A
T
R
V
R
A
A
G
G
L
V
I
S
D
E
V
Q
S
G
F
G
R
T
G
--
S
G
M
W
G
Y
Q
M
F
N
V
E
P
E
L
V
T
M
G
K
P
M
G
N
G
-
H
-
P
I
G
A
-
V
V
T
T
A
E
L
L
---
D
E
F
G
--
R
-
H
-------
N
-----
M
-----
F
F
N
T
F
A
G
N
P
V
S
S
A
A
G
L
A
V
L
R
Y
M
D
Q
E
-
D
L
M
A
K
A
-
D
Q
L
G
K
Y
I
R
K
R
L
-
E
N
I
A
Q
R
---
S
G
N
--
V
G
S
V
R
G
--
R
G
L
F
F
G
I
D
I
I
E
S
D
G
S
-----
R
-------
N
---
P
A
P
A
L
-------------------
T
K
I
L
I
E
D
M
R
E
R
G
V
L
I
S
-
R
--
V
G
P
H
--
D
-
N
V
L
K
M
R
P
P
L
V
F
G
R
E
H
A
D
I
L
L
G
Q
L
E
L
S
L
A
S
----
21
Blastp_CBE
81.81
41%
-16
- C4 -
-
5G4J
2
?
B:
[18-437]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
A
R
R
Y
A
T
I
----
G
P
H
S
P
L
F
Y
R
Q
---
P
L
E
L
V
S
G
S
G
V
W
L
T
D
A
---
Q
G
K
V
Y
L
D
G
Y
--
N
--
N
----
V
--
P
--
H
--
V
G
H
A
N
---
P
A
V
A
D
A
---------
I
Y
Q
Q
L
L
T
V
---
N
-
L
----
H
---
T
R
--
Y
L
------
N
----
S
R
V
V
-
E
--
Y
A
E
A
L
L
S
K
F
-
D
G
-
A
-
L
E
R
---------------
L
F
L
T
N
S
G
S
E
A
N
E
L
A
L
R
I
A
R
Q
H
------
T
------
G
------
N
T
------
G
----
V
L
V
S
D
F
S
Y
H
G
N
T
---
T
S
L
A
---
E
I
---
T
-
T
G-
L
---
T
V
H
E
P
L
G
------
A
----
H
--------
V
R
A
------
L
R
I
--
P
D
-
V
------------
S
-
G
----
I
A
---
E
--
V
D
---
V
P
--
V
----
L
LEQS
L
A
D
V
---
D
A
A
-
I
A
S
L
Q
A
A
G
H
G
-
V
S
V
F
L
F
D
P
L
-
F
-
S
T
E
G
L
L
Q
L
P
S
-
G
Y
I
E
G
V
A
T
R
V
R
A
A
G
G
L
V
I
S
D
E
V
Q
S
G
F
G
R
T
G
--
S
G
M
W
G
Y
Q
M
F
N
V
E
P
E
L
V
T
M
G
K
P
M
G
N
G
-
H
-
P
I
G
A
-
V
V
T
T
A
E
L
L
---
D
E
F
G
--
R
-
H
-------
N
-----
M
-----
F
F
N
T
F
A
G
N
P
V
S
S
A
A
G
L
A
V
L
R
Y
M
D
Q
E
-
D
L
M
A
K
A
-
D
Q
L
G
K
Y
I
R
K
R
L
-
E
N
I
A
Q
R
---
S
G
N
--
V
G
S
V
R
G
--
R
G
L
F
F
G
I
D
I
I
E
S
D
G
S
-----
R
-------
N
---
P
A
P
A
L
-------------------
T
K
I
L
I
E
D
M
R
E
R
G
V
L
I
S
-
R
--
V
G
P
H
--
D
-
N
V
L
K
M
R
P
P
L
V
F
G
R
E
H
A
D
I
L
L
G
Q
L
E
L
S
L
A
S
----
2
PsiBlast_PDB
81.12
40%
-15
- C4 -
-
5G4J
2
?
A:
[18-437]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
A
R
R
Y
A
T
I
----
G
P
H
S
P
L
F
Y
R
Q
---
P
L
E
L
V
S
G
S
G
V
W
L
T
D
A
---
Q
G
K
V
Y
L
D
G
Y
--
N
--
N
----
V
--
P
--
H
--
V
G
H
A
N
---
P
A
V
A
D
A
---------
I
Y
Q
Q
L
L
T
V
---
N
-
L
----
H
---
T
R
--
Y
L
------
N
----
S
R
V
V
-
E
--
Y
A
E
A
L
L
S
K
F
-
D
G
-
A
-
L
E
R
---------------
L
F
L
T
N
S
G
S
E
A
N
E
L
A
L
R
I
A
R
Q
H
------
T
------
G
------
N
T
------
G
----
V
L
V
S
D
F
S
Y
H
G
N
T
---
T
S
L
A
---
E
I
---
T
-
T
G-
L
---
T
V
H
E
P
L
G
------
A
----
H
--------
V
R
A
------
L
R
I
--
P
D
-
V
------------
S
-
G
----
I
A
---
E
--
V
D
---
V
P
--
V
----
L
L
E
Q
S
L
A
D
V
---
D
A
A
-
I
A
S
L
Q
A
A
G
H
G
-
V
S
V
F
L
F
D
P
L
-
F
-
S
T
E
G
L
L
Q
L
P
S
-
G
Y
I
E
G
V
A
T
R
V
R
A
A
G
G
L
V
I
S
D
E
V
Q
S
G
F
G
R
T
G
--
S
G
M
W
G
Y
Q
M
F
N
V
E
P
E
L
V
T
M
G
K
P
M
G
N
G
-
H
-
P
I
G
A
-
V
V
T
T
A
E
L
L
---
D
E
F
G
--
R
-
H
-------
N
-----
M
-----
F
F
N
T
F
A
G
N
P
V
S
S
A
A
G
L
A
V
L
R
Y
M
D
Q
E
-
D
L
M
A
K
A
-
D
Q
L
G
K
Y
I
R
K
R
L
-
E
N
I
A
Q
R
---
S
G
N
--
V
G
S
V
R
G
--
R
G
L
F
F
G
I
D
I
I
E
S
D
G
S
-----
R
-------
N
---
P
A
P
A
L
-------------------
T
K
I
L
I
E
D
M
R
E
R
G
V
L
I
S
-
R
--
V
G
P
H
--
D
-
N
V
L
K
M
R
P
P
L
V
F
G
R
E
H
A
D
I
L
L
G
Q
L
E
L
S
L
A
S
----
1
PsiBlast_PDB
80.60
40%
-16
- C4 -
-
5G4I
3
?
A:
[18-437]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
A
R
R
Y
A
T
I
----
G
P
H
S
P
L
F
Y
R
Q
---
P
L
E
L
V
S
G
S
G
V
W
L
T
D
A
---
Q
G
K
V
Y
L
D
G
Y
--
N
--
N
----
V
--
P
--
H
--
V
G
H
A
N
---
P
A
V
A
D
A
---------
I
Y
Q
Q
L
L
T
V
---
N
-
L
----
H
---
T
R
--
Y
L
------
N
----
S
R
V
V
-
E
--
Y
A
E
A
L
L
S
K
F
-
D
G
-
A
-
L
E
R
---------------
L
F
L
T
N
S
G
S
E
A
N
E
L
A
L
R
I
A
R
Q
H
------
T
------
G
------
N
T
------
G
----
V
L
V
S
D
F
S
Y
H
G
N
T
---
T
S
L
A
---
E
I
---
T
-
T
G-
L
---
T
V
H
E
P
L
G
------
A
----
H
--------
V
R
A
------
L
R
I
--
P
D
-
V
------------
S
-
G
----
I
A
---
E
--
V
D
---
V
P
--
V
----
L
L
E
Q
S
L
A
D
V
---
D
A
A
-
I
A
S
L
Q
A
A
G
H
G
-
V
S
V
F
L
F
D
P
L
-
F
-
S
T
E
G
L
L
Q
L
P
S
-
G
Y
I
E
G
V
A
T
R
V
R
A
A
G
G
L
V
I
S
D
E
V
Q
S
G
F
G
R
T
G
--
S
G
M
W
G
Y
Q
M
F
N
V
E
P
E
L
V
T
M
G
K
P
M
G
N
G
-
H
-
P
I
G
A
-
V
V
T
T
A
E
L
L
---
D
E
F
G
--
R
-
H
-------
N
-----
M
-----
F
F
N
T
F
A
G
N
P
V
S
S
A
A
G
L
A
V
L
R
Y
M
D
Q
E
-
D
L
M
A
K
A
-
D
Q
L
G
K
Y
I
R
K
R
L
-
E
N
I
A
Q
R
---
S
G
N
--
V
G
S
V
R
G
--
R
G
L
F
F
G
I
D
I
I
E
S
D
G
S
-----
R
-------
N
---
P
A
P
A
L
-------------------
T
K
I
L
I
E
D
M
R
E
R
G
V
L
I
S
-
R
--
V
G
P
H
--
D
-
N
V
L
K
M
R
P
P
L
V
F
G
R
E
H
A
D
I
L
L
G
Q
L
E
L
S
L
A
S
----
139
Fugue
79.15
20%
-31
- C2 -
-
4A0G
2
BIODA_ARATH
A:
[27-831]
---
P
F
H
L
P
L
N
H
P
T
Y
L
I
--
W
S
A
N
T
S
L
G
K
T
L
V
S
T
G
I
A
A
S
F
L
L
Q
Q
P
S
S
S
A
T
---------------
K
L
L
Y
L
K
P
I
Q
T
G
F
P
S
D
S
D
S
R
F
V
F
S
K
L
D
S
L
S
L
R
R
Q
I
P
--------
I
S
I
S
N
S
V
L
H
S
S
L
P
A
A
K
S
L
G
L
N
V
E
V
S
E
------------------
S
G
M
C
S
L
N
F
R
D
E
K
----
T
V
T
G
A
P
E
L
L
C
K
T
L
Y
A
W
E
A
A
I
S
P
H
L
A
A
E
R
E
N
A
T
V
E
D
S
V
V
L
Q
M
I
E
K
C
L
K
E
E
M
D
L
L
C
L
V
E
T
A
G
G
V
A
S
P
G
P
S
G
T
L
Q
C
D
L
Y
R
P
F
R
L
P
G
I
L
VGDG
R
L
G
G
I
S
G
T
I
A
A
Y
E
S
L
K
L
R
G
Y
D
----
I
A
A
V
V
F
E
D
H
G
L
V
N
E
V
P
L
T
S
Y
L
R
N
K
V
P
V
L
V
L
P
P
V
P
K
D
P
S
-
D
D
L
I
E
W
F
V
E
-------
S
D
G
V
F
K
A
L
K
E
T
M
V
L
A
N
L
E
R
L
E
R
L
N
G
M
A
K
L
A
G
E
V
F
W
W
P
----
F
T
Q
H
K
L
V
H
Q
E
T
V
T
V
I
D
S
R
C
G
E
N
F
S
I
Y
K
A
---
S
D
N
S
S
L
S
Q
Q
--
F
--
D
----
A
--
C
--
A
--
S
W
W
T
Q
G
P
D
P
T
F
Q
A
E
---------
L
A
R
E
M
G
Y
T
---
A
-
A
----
R
---
F
G
--
H
V
MFPENV
Y
----
E
P
A
L
-
K
--
C
A
E
L
L
L
D
G
V
-
G
K
-
G
W
A
S
R
---------------
V
Y
F
S
D
N
G
S
T
A
I
E
I
A
L
K
M
A
F
R
K
------
F
------
C
V
D
H
NFI
V
V
------
K
----
V
I
A
L
R
G
S
Y
H
G
D
T
---
L
G
A
M
---
E
A
QAP
S
-
P
--
Y
TG-
F
L
Q
Q
P
W
Y
T
--
G
R
G
L
----
F
L
D
P
P
T
---
V
F
L
S
NG
S
W
N
I
S
L
--
P
E
S
F
SEIAPEYGTFTS
R
-
D
----
E
I
---
F
--
D
K
---
S
R
--
D
----
A
----
S
T
L
A
---
R
I
Y
-
S
A
Y
L
S
K
H
L
A
H
-
V
G
A
L
I
I
E
P
V
-
I
H
G
A
G
G
M
H
M
V
D
P
-
L
F
Q
R
V
L
V
N
E
C
R
N
R
K
I
P
V
I
F
D
E
V
F
T
G
F
W
R
L
G
--
V
E
-
T
T
T
E
L
L
G
C
K
P
D
I
A
C
F
A
K
L
L
T
G
G
-
M
V
P
L
A
V
-
T
L
A
T
D
A
V
F
---
D
S
F
S
--
G
-
D
-------
S
-----
K
L
KALL
H
G
H
S
Y
S
A
H
A
M
G
C
A
T
A
A
K
A
I
Q
W
F
K
D
P
-
E
T
N
H
N
I
-
T
S
Q
G
K
T
L
R
E
L
W
D
E
E
L
V
Q
Q
I
S
S
H
S
A
--
V
Q
R
V
V
V
--
I
G
T
L
F
A
L
E
L
K
S
------------------------
L
Y
-------------------
A
K
S
L
L
I
M
L
R
E
D
G
I
F
T
R
------
P
L
--
G
-
N
V
I
Y
L
M
C
G
P
C
T
S
P
E
I
C
R
R
L
L
T
K
L
Y
K
R
L
G
E
F
N
R
T
8
PsiBlast_PDB
75.81
33%
-17
- C4 -
-
1ZC9
1
DGDA_BURCE
A:
[20-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
G
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
Q
--
M
--
S
AV
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
E
Y
A
G
K
L
---
D
H
L
----
F
---
S
E
--
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
------
G
------
K
Y
------
E
----
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
----
Y
---
S
A
G
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
----
R
F
---
E
--
R
N
---
G
A
--
Y
D---
Y
----
L
A
E
L
---
D
Y
A
F
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
--
E
-
L
-------
G
-----
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
I
V
--
Q
L
P
G
--
M
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
------
90
Blastp_CBE
75.68
33%
-24
- C4 -
-
5LH9
2
?
A:
[37-455]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
I
A
R
G
D
G
N
Y
I
T
D
I
---
D
G
Q
R
M
L
D
G
V
--
G
--
G
----
L
WN
V
--
N
--
I
G
H
N
R
---
A
S
V
K
A
A
---------
I
A
A
Q
L
D
E
L
AYY
Q
-
T
----
F
---
D
G
--
I
A
------
H
----
P
R
V
F
-
D
--
L
A
E
R
L
T
G
M
F
-
A
Q
-
E
R
M
A
R
---------------
V
L
F
S
S
G
G
S
D
A
V
E
T
A
L
K
M
A
R
Q
Y
W
I
A
S
GE
P
------
G
------
R
T
------
R
----
F
L
S
L
R
N
G
Y
H
G
--------
V
---
H
M
---
G
-
G
--
T
---
S
V
---
G
G
N
--
G
V
Y
H
----
Y
NHGQLLAG
C
H
L
------
L
D
T
--
P
W
L
Y
------------
R
-
N
----
P
W
---
D
--
C
R
---
D
P
--
Q
----
A
----
L
T
A
H
C
I
R
Q
L
E
-
E
Q
I
A
L
L
G
A
Q
T
-
I
A
A
L
I
A
E
P
V
-
Q
-
G
A
G
G
V
I
V
P
P
A
-
D
Y
W
P
R
L
R
E
V
C
D
R
H
G
I
L
L
I
A
D
E
V
V
T
G
F
G
R
S
G
---
C
M
L
G
S
R
G
W
G
V
A
P
D
I
L
C
L
A
K
G
I
T
A
G
-
Y
I
P
L
G
A
-
T
L
F
N
Q
R
I
A
---
D
A
I
E
--
N
-
G
-------
Q
GFSHM
I
M
----
H
G
Y
T
Y
S
G
H
P
T
A
C
A
A
A
L
A
V
L
D
I
V
E
A
E
-
D
L
P
G
N
A
-
A
K
V
G
A
Q
L
---
L
-
E
Q
L
--
Q
P
L
V
E
R
Y
AV
V
G
E
V
R
G
--
K
G
L
M
I
A
L
D
L
V
S
D
K
R
T
-----
R
-------
Q
PLD
P
A
A
G
Q
-------------------
P
S
R
I
A
D
E
A
R
R
A
G
V
L
V
R
------
P
I
--
G
-
N
K
I
I
L
S
P
P
L
T
L
T
R
D
E
A
G
L
M
V
S
A
L
E
A
A
F
A
-----
88
Blastp_CBE
75.49
33%
-26
- C4 -
-
5LH9
2
?
C:
[37-455]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
I
A
R
G
D
G
N
Y
I
T
D
I
---
D
G
Q
R
M
L
D
G
V
--
G
--
G
----
L
WN
V
--
N
--
I
G
H
N
R
---
A
S
V
K
A
A
---------
I
A
A
Q
L
D
E
L
AYY
Q
-
T
----
F
---
D
G
--
I
A
------
H
----
P
R
V
F
-
D
--
L
A
E
R
L
T
G
M
F
-
A
Q
-
E
R
M
A
R
---------------
V
L
F
S
S
G
G
S
D
A
V
E
T
A
L
K
M
A
R
Q
Y
W
I
A
S
GE
P
------
G
------
R
T
------
R
----
F
L
S
L
R
N
G
Y
H
G
--------
V
---
H
M
---
G
-
G
--
T
---
S
V
---
G
G
N
--
G
V
Y
H
----
Y
NHGQLLAG
C
H
L
------
L
D
T
--
P
W
L
Y
------------
R
-
N
----
P
W
---
D
--
C
R
---
D
P
--
Q
----
A
----
L
T
A
H
C
I
R
Q
L
E
-
E
Q
I
A
L
L
G
A
Q
T
-
I
A
A
L
I
A
E
P
V
-
Q
-
G
A
G
G
V
I
V
P
P
A
-
D
Y
W
P
R
L
R
E
V
C
D
R
H
G
I
L
L
I
A
D
E
V
V
T
G
F
G
R
S
G
---
C
M
L
G
S
R
G
W
G
V
A
P
D
I
L
C
L
A
K
G
I
T
A
G
-
Y
I
P
L
G
A
-
T
L
F
N
Q
R
I
A
---
D
A
I
E
--
N
-
G
-------
Q
GFSHM
I
M
----
H
G
Y
T
Y
S
G
H
P
T
A
C
A
A
A
L
A
V
L
D
I
V
E
A
E
-
D
L
P
G
N
A
-
A
K
V
G
A
Q
L
---
L
-
E
Q
L
--
Q
P
L
V
E
R
Y
AV
V
G
E
V
R
G
--
K
G
L
M
I
A
L
D
L
V
S
D
K
R
T
-----
R
-------
Q
PLD
P
A
A
G
Q
-------------------
P
S
R
I
A
D
E
A
R
R
A
G
V
L
V
R
------
P
I
--
G
-
N
K
I
I
L
S
P
P
L
T
L
T
R
D
E
A
G
L
M
V
S
A
L
E
A
A
F
A
-----
130
Fugue
75.32
32%
-12
- C4 -
-
1D7U
1
DGDA_BURCE
A:
[3-433]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
D
D
A
T
F
W
R
N
A
R
Q
H
L
V
----
R
Y
G
G
------
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
Q
--
M
--
S
AV
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
-
E
Y
A
G
K
---
L
--DHLF
S
---
G
---
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
----------------------G
K
Y
E
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
Y
S
--
A
----
G
-
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
RFER-----
N
--
G
A
---
Y
D
--
Y
----
L
----
A
E
L
D
---
Y
A
F
-
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
E
L
--
G
-------------
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
-
I
--
V
Q
L
P
GM
G
-
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
E
R
A
L
--
89
Blastp_CBE
75.18
33%
-24
- C4 -
-
5LH9
2
?
B:
[37-455]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
I
A
R
G
D
G
N
Y
I
T
D
I
---
D
G
Q
R
M
L
D
G
V
--
G
--
G
----
L
WN
V
--
N
--
I
G
H
N
R
---
A
S
V
K
A
A
---------
I
A
A
Q
L
D
E
L
AYY
Q
-
T
----
F
---
D
G
--
I
A
------
H
----
P
R
V
F
-
D
--
L
A
E
R
L
T
G
M
F
-
A
Q
-
E
R
M
A
R
---------------
V
L
F
S
S
G
G
S
D
A
V
E
T
A
L
K
M
A
R
Q
Y
W
I
A
S
GE
P
------
G
------
R
T
------
R
----
F
L
S
L
R
N
G
Y
H
G
--------
V
---
H
M
---
G
-
G
--
T
---
S
V
---
G
G
N
--
G
V
Y
H
----
Y
NHGQLLAG
C
H
L
------
L
D
T
--
P
W
L
Y
------------
R
-
N
----
P
W
---
D
--
C
R
---
D
P
--
Q
----
A
----
L
T
A
H
C
I
R
Q
L
E
-
E
Q
I
A
L
L
G
A
Q
T
-
I
A
A
L
I
A
E
P
V
-
Q
-
G
A
G
G
V
I
V
P
P
A
-
D
Y
W
P
R
L
R
E
V
C
D
R
H
G
I
L
L
I
A
D
E
V
V
T
G
F
G
R
S
G
---
C
M
L
G
S
R
G
W
G
V
A
P
D
I
L
C
L
A
K
G
I
T
A
G
-
Y
I
P
L
G
A
-
T
L
F
N
Q
R
I
A
---
D
A
I
E
--
N
-
G
-------
Q
GFSHM
I
M
----
H
G
Y
T
Y
S
G
H
P
T
A
C
A
A
A
L
A
V
L
D
I
V
E
A
E
-
D
L
P
G
N
A
-
A
K
V
G
A
Q
L
---
L
-
E
Q
L
--
Q
P
L
V
E
R
Y
AV
V
G
E
V
R
G
--
K
G
L
M
I
A
L
D
L
V
S
D
K
R
T
-----
R
-------
Q
PLD
P
A
A
G
Q
-------------------
P
S
R
I
A
D
E
A
R
R
A
G
V
L
V
R
------
P
I
--
G
-
N
K
I
I
L
S
P
P
L
T
L
T
R
D
E
A
G
L
M
V
S
A
L
E
A
A
F
A
-----
83
Blastp_CBE
75.11
33%
-25
- C4 -
-
5LHA
2
?
D:
[37-455]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
I
A
R
G
D
G
N
Y
I
T
D
I
---
D
G
Q
R
M
L
D
G
V
--
G
--
G
----
L
WN
V
--
N
--
I
G
H
N
R
---
A
S
V
K
A
A
---------
I
A
A
Q
L
D
E
L
AYY
Q
-
T
----
F
---
D
G
--
I
A
------
H
----
P
R
V
F
-
D
--
L
A
E
R
L
T
G
M
F
-
A
Q
-
E
R
M
A
R
---------------
V
L
F
S
S
G
G
S
D
A
V
E
T
A
L
K
M
A
R
Q
Y
WIASGE
P
------
G
------
R
T
------
R
----
F
L
S
L
R
N
G
Y
H
G
--------
V
---
H
M
---
G
-
G
--
T
---
S
V
---
G
G
N
--
G
V
Y
H
----
Y
NHGQLLAG
C
H
L
------
L
D
T
--
P
W
L
Y
------------
R
-
N
----
P
W
---
D
--
C
R
---
D
P
--
Q
----
A
----
L
T
A
H
CIR
Q
L
E
-
E
Q
I
A
L
L
G
A
Q
T
-
I
A
A
L
I
A
E
P
V
-
Q
-
G
A
G
G
V
I
V
P
P
A
-
D
Y
W
P
R
L
R
E
V
C
D
R
H
G
I
L
L
I
A
D
E
V
V
T
G
F
G
R
S
G
---
C
M
L
G
S
R
G
W
G
V
A
P
D
I
L
C
L
A
K
G
I
T
A
G
-
Y
I
P
L
G
A
-
T
L
F
N
Q
R
I
A
---
D
A
I
E
--
N
-
G
-------
Q
GFSHM
I
M
----
H
G
Y
T
Y
S
G
H
P
T
A
C
A
A
A
L
A
V
L
D
I
V
E
A
E
-
D
L
P
G
N
A
-
A
K
V
G
A
Q
L
---
L
-
E
Q
L
--
Q
P
L
V
E
R
Y
AV
V
G
E
V
R
G
--
K
G
L
M
I
A
L
D
L
V
S
D
K
R
T
-----
R
-------
Q
PLD
P
A
A
G
Q
-------------------
P
S
R
I
A
D
E
A
R
R
A
G
V
L
V
R
------
P
I
--
G
-
N
K
I
I
L
S
P
P
L
T
L
T
R
D
E
A
G
L
M
V
S
A
L
E
A
A
F
A
-----
87
Blastp_CBE
75.01
33%
-23
- C4 -
-
5LH9
2
?
D:
[37-455]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
I
A
R
G
D
G
N
Y
I
T
D
I
---
D
G
Q
R
M
L
D
G
V
--
G
--
G
----
L
WN
V
--
N
--
I
G
H
N
R
---
A
S
V
K
A
A
---------
I
A
A
Q
L
D
E
L
AYY
Q
-
T
----
F
---
D
G
--
I
A
------
H
----
P
R
V
F
-
D
--
L
A
E
R
L
T
G
M
F
-
A
Q
-
E
R
M
A
R
---------------
V
L
F
S
S
G
G
S
D
A
V
E
T
A
L
K
M
A
R
Q
Y
WIASGE
P
------
G
------
R
T
------
R
----
F
L
S
L
R
N
G
Y
H
G
--------
V
---
H
M
---
G
-
G
--
T
---
S
V
---
G
G
N
--
G
V
Y
H
----
Y
NHGQLLAG
C
H
L
------
L
D
T
--
P
W
L
Y
------------
R
-
N
----
P
W
---
D
--
C
R
---
D
P
--
Q
----
A
----
L
T
A
H
CIR
Q
L
E
-
E
Q
I
A
L
L
G
A
Q
T
-
I
A
A
L
I
A
E
P
V
-
Q
-
G
A
G
G
V
I
V
P
P
A
-
D
Y
W
P
R
L
R
E
V
C
D
R
H
G
I
L
L
I
A
D
E
V
V
T
G
F
G
R
S
G
---
C
M
L
G
S
R
G
W
G
V
A
P
D
I
L
C
L
A
K
G
I
T
A
G
-
Y
I
P
L
G
A
-
T
L
F
N
Q
R
I
A
---
D
A
I
E
--
N
-
G
-------
Q
GFSHM
I
M
----
H
G
Y
T
Y
S
G
H
P
T
A
C
A
A
A
L
A
V
L
D
I
V
E
A
E
-
D
L
P
G
N
A
-
A
K
V
G
A
Q
L
---
L
-
E
Q
L
--
Q
P
L
V
E
R
Y
AV
V
G
E
V
R
G
--
K
G
L
M
I
A
L
D
L
V
S
D
K
R
T
-----
R
-------
Q
PLD
P
A
A
G
Q
-------------------
P
S
R
I
A
D
E
A
R
R
A
G
V
L
V
R
------
P
I
--
G
-
N
K
I
I
L
S
P
P
L
T
L
T
R
D
E
A
G
L
M
V
S
A
L
E
A
A
F
A
-----
7
PsiBlast_PDB
74.88
33%
-14
- C4 -
-
1M0Q
1
DGDA_BURCE
A:
[20-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
G
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
Q
--
M
--
S
AV
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
E
Y
A
G
K
L
---
D
H
L
----
F
---
S
E
--
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
------
G
------
K
Y
------
E
----
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
----
Y
---
S
A
G
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
----
R
F
---
E
--
R
N
---
G
A
--
Y
D---
Y
----
L
A
E
L
---
D
Y
A
F
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
--
E
-
L
-------
G
-----
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
I
V
--
Q
L
P
G
--
M
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
------
17
PsiBlast_PDB
74.82
33%
-12
- C4 -
-
1DGD
2
DGDA_BURCE
A:
[19-428]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
G
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
Q
--
M
--
S
AV
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
E
Y
A
G
K
L
---
D
H
L
----
F
---
S
G
--
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
------
G
------
K
Y
------
E
----
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
----
Y
---
S
A
G
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
----
R
F
---
E
--
R
N
---
G
A
--
Y
D---
Y
----
L
A
E
L
---
D
Y
A
F
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
--
E
-
L
-------
G
-----
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
I
V
--
Q
L
P
G
--
M
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
------
3
PsiBlast_PDB
74.81
33%
-14
- C4 -
-
1Z3Z
2
DGDA_BURCE
A:
[18-427]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
G
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
A
--
M
--
S
AV
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
E
Y
A
G
K
L
---
D
H
L
----
F
---
S
E
--
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
------
G
------
K
Y
------
E
----
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
----
Y
---
S
A
G
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
----
R
F
---
E
--
R
N
---
G
A
--
Y
D---
Y
----
L
A
E
L
---
D
Y
A
F
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
--
E
-
L
-------
G
-----
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
I
V
--
Q
L
P
G
--
M
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
------
11
PsiBlast_PDB
74.78
33%
-12
- C4 -
-
1DKA
2
DGDA_BURCE
A:
[20-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
G
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
Q
--
M
--
S
AV
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
E
Y
A
G
K
L
---
D
H
L
----
F
---
S
E
--
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
------
G
------
K
Y
------
E
----
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
----
Y
---
S
A
G
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
----
R
F
---
E
--
R
N
---
G
A
--
Y
D---
Y
----
L
A
E
L
---
D
Y
A
F
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
--
E
-
L
-------
G
-----
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
I
V
--
Q
L
P
G
--
M
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
------
12
PsiBlast_PDB
74.76
33%
-13
- C4 -
-
2DKB
2
DGDA_BURCE
A:
[20-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
G
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
Q
--
M
--
S
AV
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
E
Y
A
G
K
L
---
D
H
L
----
F
---
S
E
--
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
------
G
------
K
Y
------
E
----
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
----
Y
---
S
A
G
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
----
R
F
---
E
--
R
N
---
G
A
--
Y
D---
Y
----
L
A
E
L
---
D
Y
A
F
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
--
E
-
L
-------
G
-----
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
I
V
--
Q
L
P
G
--
M
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
------
13
PsiBlast_PDB
74.73
33%
-14
- C4 -
-
1D7R
1
DGDA_BURCE
A:
[20-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
G
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
Q
--
M
--
S
AV
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
E
Y
A
G
K
L
---
D
H
L
----
F
---
S
G
--
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
------
G
------
K
Y
------
E
----
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
----
Y
---
S
A
G
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
----
R
F
---
E
--
R
N
---
G
A
--
Y
D---
Y
----
L
A
E
L
---
D
Y
A
F
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
--
E
-
L
-------
G
-----
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
I
V
--
Q
L
P
G
--
M
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
------
15
PsiBlast_PDB
74.66
33%
-13
- C4 -
-
1D7U
1
DGDA_BURCE
A:
[20-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
G
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
Q
--
M
--
S
AV
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
E
Y
A
G
K
L
---
D
H
L
----
F
---
S
G
--
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
------
G
------
K
Y
------
E
----
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
----
Y
---
S
A
G
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
----
R
F
---
E
--
R
N
---
G
A
--
Y
D---
Y
----
L
A
E
L
---
D
Y
A
F
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
--
E
-
L
-------
G
-----
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
I
V
--
Q
L
P
G
--
M
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
------
10
PsiBlast_PDB
74.52
33%
-14
- C4 -
-
1ZOD
2
DGDA_BURCE
A:
[20-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
G
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
Q
--
M
--
S
AV
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
E
Y
A
G
K
L
---
D
H
L
----
F
---
S
E
--
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
------
G
------
K
Y
------
E
----
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
----
Y
---
S
A
G
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
----
R
F
---
E
--
R
N
---
G
A
--
Y
D---
Y
----
L
A
E
L
---
D
Y
A
F
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
--
E
-
L
-------
G
-----
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
I
V
--
Q
L
P
G
--
M
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
------
4
PsiBlast_PDB
74.49
33%
-15
- C4 -
-
1M0N
1
DGDA_BURCE
A:
[20-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
G
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
Q
--
M
--
S
AV
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
E
Y
A
G
K
L
---
D
H
L
----
F
---
S
E
--
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
------
G
------
K
Y
------
E
----
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
----
Y
---
S
A
G
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
----
R
F
---
E
--
R
N
---
G
A
--
Y
D---
Y
----
L
A
E
L
---
D
Y
A
F
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
--
E
-
L
-------
G
-----
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
I
V
--
Q
L
P
G
--
M
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
------
14
PsiBlast_PDB
74.34
33%
-13
- C4 -
-
1D7S
1
DGDA_BURCE
A:
[20-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
G
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
Q
--
M
--
S
AV
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
E
Y
A
G
K
L
---
D
H
L
----
F
---
S
G
--
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
------
G
------
K
Y
------
E
----
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
----
Y
---
S
A
G
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
----
R
F
---
E
--
R
N
---
G
A
--
Y
D---
Y
----
L
A
E
L
---
D
Y
A
F
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
--
E
-
L
-------
G
-----
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
I
V
--
Q
L
P
G
--
M
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
------
5
PsiBlast_PDB
74.34
33%
-14
- C4 -
-
1M0O
1
DGDA_BURCE
A:
[20-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
G
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
Q
--
M
--
S
AV
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
E
Y
A
G
K
L
---
D
H
L
----
F
---
S
E
--
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
------
G
------
K
Y
------
E
----
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
----
Y
---
S
A
G
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
----
R
F
---
E
--
R
N
---
G
A
--
Y
D---
Y
----
L
A
E
L
---
D
Y
A
F
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
--
E
-
L
-------
G
-----
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
I
V
--
Q
L
P
G
--
M
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
------
18
PsiBlast_PDB
74.07
33%
-12
- C4 -
-
1DGE
2
DGDA_BURCE
A:
[19-428]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
G
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
Q
--
M
--
S
AV
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
E
Y
A
G
K
L
---
D
H
L
----
F
---
S
G
--
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
------
G
------
K
Y
------
E
----
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
----
Y
---
S
A
G
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
----
R
F
---
E
--
R
N
---
G
A
--
Y
D---
Y
----
L
A
E
L
---
D
Y
A
F
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
--
E
-
L
-------
G
-----
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
I
V
--
Q
L
P
G
--
M
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
------
9
PsiBlast_PDB
73.95
33%
-15
- C4 -
-
1ZOB
2
DGDA_BURCE
A:
[20-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
G
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
Q
--
M
--
S
AV
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
E
Y
A
G
K
L
---
D
H
L
----
F
---
S
E
--
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
------
G
------
K
Y
------
E
----
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
----
Y
---
S
A
G
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
----
R
F
---
E
--
R
N
---
G
A
--
Y
D---
Y
----
L
A
E
L
---
D
Y
A
F
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
--
E
-
L
-------
G
-----
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
I
V
--
Q
L
P
G
--
M
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
------
16
PsiBlast_PDB
73.69
33%
-14
- C4 -
-
1D7V
1
DGDA_BURCE
A:
[20-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
G
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
Q
--
M
--
S
AV
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
E
Y
A
G
K
L
---
D
H
L
----
F
---
S
G
--
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
------
G
------
K
Y
------
E
----
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
----
Y
---
S
A
G
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
----
R
F
---
E
--
R
N
---
G
A
--
Y
D---
Y
----
L
A
E
L
---
D
Y
A
F
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
--
E
-
L
-------
G
-----
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
I
V
--
Q
L
P
G
--
M
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
------
6
PsiBlast_PDB
73.30
33%
-10
- C4 -
-
1M0P
1
DGDA_BURCE
A:
[20-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
G
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
Q
--
M
--
S
AV
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
E
Y
A
G
K
L
---
D
H
L
----
F
---
S
E
--
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
------
G
------
K
Y
------
E
----
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
----
Y
---
S
A
G
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
----
R
F
---
E
--
R
N
---
G
A
--
Y
D---
Y
----
L
A
E
L
---
D
Y
A
F
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
--
E
-
L
-------
G
-----
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
I
V
--
Q
L
P
G
--
M
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
------
147
SP3
70.04
17%
-14
- C4 -
-
2DKB
2
?
?:
[3-433]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
D
D
A
T
F
W
R
N
A
R
H
H
L
----
V
R
-----
Y
G
G
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
---
D
G
R
A
I
L
D
F
T
--
S
--
G
----
Q
--
M
SA
V
--
L
G
H
C
H
---
P
E
I
V
S
V
---------
I
G
E
Y
A
G
K
L
---
D
-
H
L---
F
---
S
E
--
M
L
------
S
----
R
P
V
V
-
D
--
L
A
T
R
L
A
N
I
T
-
P
P
-
G
-
L
D
R
---------------
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
------
T
------
G
------
K
Y
------
E
----
I
V
G
F
A
Q
S
W
H
G
M
T
---
G
A
A
A
---
S
A
---
T
-
Y
--
S
---
A
-
G
R
K
G
V
G
--
P
A
A
V
----
G
--------
S
F
A
------
I
P
A
--
P
F
T
Y
------------
R
-
P
----
R
F
---
E
--
R
N
---
G
A
YD
Y
----
L
----
A
E
L
D
---
Y
A
F
-
D
L
I
D
R
Q
S
S
G
N
-
L
A
A
F
I
A
E
P
I
-
L
-
S
S
G
G
I
I
E
L
P
D
-
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
--
T
-
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
-
I
V
T
S
A
A
I
E
---
E
R
A
H
--
E
-
L
-------
G
-----
Y
L
----
F
Y
T
T
H
V
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
-
G
L
V
A
R
A
-
N
V
M
G
D
R
L
R
R
G
L
-
L
D
L
M
E
R
F
---
D
C
--
I
G
D
V
R
G
--
R
G
L
L
L
G
V
E
I
V
K
D
R
R
T
-----
K
-------
E
---
P
A
D
G
L
-------------------
G
A
K
I
T
R
E
C
M
N
L
G
L
S
M
N
-
I
V
Q
L
P
G
M
--
G
-
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
E
R
A
L
--
51
Blastp_CBE
68.71
34%
-13
- C4 -
-
5M4B
2
?
A:
[26-424]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
L
A
V
A
G
G
Q
G
A
R
L
V
E
E
---
D
G
R
E
L
I
D
L
S
--
G
AW
G
----
A
--
A
--
S
--
L
G
Y
G
H
---
P
A
I
I
E
A
V
S
R
A
A
A
NPA
G
A
S
I
L
S
A
S
---
N
-
A
----
P
---
A
-------------------
V
-
A
--
L
A
E
R
L
T
A
S
F
-
P
-R
G
-
T
H
K
---------------
V
W
F
G
H
S
G
S
D
A
N
E
A
A
Y
R
A
I
T
R
A
------
T
------
G
------
R
T
------
G
----
V
I
A
F
I
G
A
Y
H
G
C
T
---
V
G
S
M
---
A
F
---
S
-
G
--
H
---
S
V
Q
A
D
A
A
K
--
A
--
D
----
G
--------
L
I
L
------
L
P
Y
--
P
D
P
Y
------------
R
-
P
----
Y
Q
---
D
--
D
P
---
T
G
--
D
----
A
----
V
L
A
L
---
L
K
E
-
R
L
A
A
V
P
A
G
S
--
I
A
A
A
F
I
E
P
I
-
Q
-
S
A
G
G
L
I
V
P
P
D
-
G
F
L
R
K
F
A
D
I
C
R
A
H
G
I
S
V
V
C
D
E
V
K
V
G
L
A
R
S
G
--
R
-
L
H
C
F
E
H
E
G
F
V
P
D
I
L
V
L
G
K
G
L
G
G
G
-
L
-
P
L
S
A
-
V
I
A
P
A
E
I
L
---
D
C
A
S
--
A
-
F
-------
A
-----
M
Q
-------
T
L
H
G
N
P
V
C
A
A
A
G
L
A
V
L
E
T
I
E
A
E
-
N
L
T
T
A
A
-
E
R
K
G
K
L
L
R
E
G
L
-
A
R
L
A
E
R
H
E
L
-----
I
G
D
I
R
G
--
R
G
L
A
C
G
V
E
L
V
R
N
R
Q
S
-----
R
-------
E
---
P
A
R
A
E
-------------------
T
A
K
L
I
Y
R
A
Y
E
L
G
L
V
L
Y
-
Y
--
V
G
M
N
--
G
-
N
V
L
E
M
T
P
P
L
T
M
T
E
D
E
V
R
H
A
V
N
L
L
D
Q
A
F
T
-----
79
Blastp_CBE
68.27
31%
-8
- C4 -
-
5GHF
1
?
A:
[31-448]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
V
I
E
R
G
D
G
I
Y
V
E
D
V
---
S
G
K
R
Y
I
E
A
M
--
S
--
G
----
L
WS
V
--
G
--
V
G
F
S
E
---
P
R
L
A
E
A
---------
A
A
R
Q
M
K
K
L
PFY
H
---------------------------
G
P
V
I
-
D
--
L
A
E
K
L
V
S
M
A
-
P
V
-
P
-
M
S
K
---------------
A
Y
F
T
N
S
G
S
E
A
N
D
T
V
V
K
L
I
W
Y
R
------
S
------
N
------
A
L
GEPERK
K
----
I
I
S
R
K
R
G
Y
H
G
V
T
I
A
S
A
S
L
T
---
G
L
PN-
N
-
H
--
R
---
S
F
D
L
P
I
D
R
---------------------
I
------
L
H
T
G
C
P
H
F
Y
------------
R
E
G
----
Q
A
---
G
--
E
S
---
E
E
--
Q
----
F
----
A
T
R
L
A
--
D
E
L
-
E
Q
L
I
I
A
E
G
P
H
T
I
A
A
F
I
G
E
P
V
-
M
-
G
A
G
G
V
V
V
P
P
K
-
T
Y
W
E
K
V
Q
A
V
L
K
R
Y
D
I
L
L
I
A
D
E
V
I
C
G
F
G
R
T
G
--
N
-
L
F
G
S
Q
T
F
D
M
K
P
D
I
L
V
M
S
K
Q
L
S
S
S
-
Y
L
P
I
S
A
F
L
I
N
E
R
V
Y
A
PIA---------------------------------
S
G
H
P
V
A
A
A
V
A
L
E
N
L
A
I
I
E
E
R
-
D
L
V
A
N
A
-
R
D
R
G
T
Y
M
Q
K
R
L
-
R
E
L
Q
D
H
P
L
------
V
G
E
V
R
G
--
V
G
L
I
A
G
V
E
L
V
T
D
K
Q
A
-----
K
TGL----
E
---
P
T
G
A
L
-------------------
G
A
K
A
N
A
V
L
Q
E
R
G
V
I
S
R
-
A
--
M
G
------
D
T
L
A
F
C
P
P
L
I
I
N
D
Q
Q
V
D
T
M
V
S
A
L
E
A
T
L
N
-----
52
Blastp_CBE
68.16
34%
-14
- C4 -
-
5M46
6
?
A:
[26-424]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
L
A
V
A
G
G
Q
G
A
R
L
V
E
E
---
D
G
R
E
L
I
D
L
S
--
G
AW
G
----
A
--
A
--
S
--
L
G
Y
G
H
---
P
A
I
I
E
A
V
S
R
A
A
A
N
PA
G
A
S
I
L
S
A
S
---
N
-
A
----
P
---
A
-------------------
V
-
A
--
L
A
E
R
L
T
A
S
F
-
P
G
R
G
-
T
H
K
---------------
V
W
F
G
H
S
G
S
D
A
N
E
A
A
Y
R
A
I
T
R
A
------
T
------
G
------
R
T
------
G
----
V
I
A
F
I
G
A
Y
H
G
C
T
---
V
G
S
M
---
A
F
---
S
-
G
--
H
-------------
A
--
D
----
G
--------
L
I
L
------
L
P
Y
--
P
D
P
Y
------------
R
-
P
----
Y
Q
---
D
--
D
P
---
T
G
--
D
----
A
----
V
L
A
L
---
L
K
E
-
R
L
A
A
V
P
A
G
S
--
I
A
A
A
F
I
E
P
I
-
Q
-
S
D
G
G
L
I
V
P
P
D
-
G
F
L
R
K
F
A
D
I
C
R
A
H
G
I
S
V
V
C
D
E
V
K
V
G
L
A
R
S
G
--
R
-
L
H
C
F
E
H
E
G
F
V
P
D
I
L
V
L
G
K
G
L
G
G
G
-
L
-
P
L
S
A
-
V
I
A
P
A
E
I
L
---
D
C
A
S
--
A
-
F
-------
A
-----
M
Q
-------
T
L
H
G
N
P
V
C
A
A
A
G
L
A
V
L
E
T
I
E
A
E
-
N
L
T
T
A
A
-
E
R
K
G
K
L
L
R
E
G
L
-
A
R
L
A
E
R
H
E
L
-----
I
G
D
I
R
G
--
R
G
L
A
C
G
V
E
L
V
R
N
R
Q
S
-----
R
-------
E
---
P
A
R
A
E
-------------------
T
A
K
L
I
Y
R
A
Y
E
L
G
L
V
L
Y
-
Y
--
V
G
M
N
--
G
-
N
V
L
E
M
T
P
P
L
T
M
T
E
D
E
V
R
H
A
V
N
L
L
D
Q
A
F
T
-----
80
Blastp_CBE
67.95
33%
-5
* C4 *
-
3DXV
2
ACLR_ACHOB
B:
[25-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
L
A
I
S
G
G
R
G
A
R
L
I
E
E
---
N
G
R
E
L
I
D
L
S
--
G
--
A
WGAA
S
--
L
--
G
--
Y
G
H
P
A
---
I
V
A
A
V
S
---------
A
A
A
A
N
P
A
G
---
A
-
T
----
I
---
L
S
--
A
S
------
N
----
A
P
A
V
-
T
--
L
A
E
R
L
L
A
S
F
-
P
G
-
E
G
T
H
K
---------------
I
W
F
G
H
S
G
S
D
A
N
E
A
A
Y
R
A
I
V
K
A
------
T
------
G
------
R
S
------
G
----
V
I
A
F
A
G
A
Y
H
G
C
T
---
V
G
S
M
---
A
F
---
S
-
G
--
H
---
S
V
Q
A
D
A
A
K
--
A
--
D
----
G
--------
L
I
L
------
L
P
Y
--
P
D
P
Y
------------
R
-
P
----
Y
R
---
N
--
D
P
---
T
G
--
D
----
A
----
I
L
T
L
---
L
T
E
-
K
L
A
A
V
P
A
G
S
--
I
G
A
A
F
I
E
P
I
-
Q
-
S
D
G
G
L
I
V
P
P
D
-
G
F
L
R
K
F
A
D
I
C
R
A
H
G
I
L
V
V
C
D
E
V
K
V
G
L
A
R
S
G
--
R
-
L
H
C
F
E
H
E
G
F
V
P
D
I
L
V
L
G
K
G
L
G
G
G
-
L
-
P
L
S
A
-
V
I
A
P
A
E
I
L
---
D
C
A
S
--
A
-
F
-------
A
-----
M
Q
-------
T
L
H
G
N
P
I
S
A
A
A
G
L
A
V
L
E
T
I
D
R
D
-
D
L
P
A
M
A
-
E
R
K
G
R
L
L
R
D
G
L
-
S
E
L
A
K
R
H
P
L
-----
I
G
D
I
R
G
--
R
G
L
A
C
G
M
E
L
V
C
D
R
Q
S
-----
R
-------
E
---
P
A
R
A
E
-------------------
T
A
K
L
I
Y
R
A
Y
Q
L
G
L
V
V
Y
-
Y
--
V
G
M
N
--
G
-
N
V
L
E
F
T
P
P
L
T
I
T
E
T
D
I
H
K
A
L
D
L
L
D
R
A
F
S
-----
164
HHSearch
67.62
25%
-60
- C4 -
-
4WYD
13
BIOA_MYCTU
A:
[54-454]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
DG
Q
P
I
E
V
L
D
A
M
--
S
--
S
----
W
WT
A
--
I
--
H
G
H
G
H
---
P
A
L
D
Q
A
---------
L
T
T
Q
L
R
V
M
---
N
-
H
----
V
MF-
G
G
--
L
T
------
H
----
E
P
A
A
-
R
--
L
A
K
L
L
V
D
I
T
-
P
A
-
G
-
L
D
T
---------------
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
GL
P
------
G
------
K
R
------
R
----
L
M
T
W
R
G
G
Y
H
G
D
T
---
F
L
A
M
---
S
I
---
C
-
D
--
P
---
H
G
G
M
H
S
L
W
TD
V
L
A
A
----
Q
--------
V
F
A
------
P
Q
V
--
P
R
D
Y
------------
D
--------------------
P
--
A
----
Y
----
S
A
A
F
---
E
A
Q
-
L
---
A
Q
H
A
G
E
-
L
A
A
V
V
V
E
P
V
V
Q
-
G
A
G
G
M
R
F
H
D
P
-
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
---
A
L
F
A
A
D
H
A
G
V
S
P
D
I
M
C
V
G
K
A
L
T
G
G
-
Y
L
S
L
A
A
-
T
L
C
T
A
D
V
A
---
H
T
I
S
--
A
-
G
AAG----
A
-----
L
M
----
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
-
D
W
R
T
R
I
-
T
E
L
A
A
G
L
T
A
G
L
-
D
T
A
R
A
----
L
P
A
--
V
T
D
V
R
V
--
C
G
A
I
G
V
I
E
C
D
R
P
V
-----------------------
D
-------------------
L
A
V
A
T
P
A
A
L
D
R
G
V
W
L
R
-
P
--
F
R
------
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
--
54
Blastp_CBE
67.41
34%
-11
- C4 -
-
5M4D
5
?
A:
[25-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
L
A
V
A
G
G
Q
G
A
R
L
V
E
E
---
D
G
R
E
L
I
D
L
S
--
G
AW
G
----
A
--
A
--
S
--
L
G
Y
G
H
---
P
A
I
I
E
A
V
S
R
A
A
A
NPA
G
A
S
I
L
S
A
S
---
N
-
A
----
P
---
A
-------------------
V
-
A
--
L
A
E
R
L
T
A
S
F
-
P
G
R
G
-
T
H
K
---------------
V
W
F
G
H
S
G
S
D
A
N
E
A
A
Y
R
A
I
T
R
A
------
T
------
G
------
R
T
------
G
----
V
I
A
F
I
G
A
Y
H
G
C
T
---
V
G
S
M
---
A
F
---
S
-
G
--
H
---
S
V
Q
A
D
A
A
K
--
A
--
D
----
G
--------
L
I
L
------
L
P
Y
--
P
D
P
Y
------------
R
-
P
----
Y
Q
---
D
--
D
P
---
T
G
--
D
----
A
----
V
L
A
L
---
L
K
E
-
R
L
A
A
V
P
A
G
S
--
I
A
A
A
F
I
E
P
I
-
Q
-
S
D
G
G
L
I
V
P
P
D
-
G
F
L
R
K
F
A
D
I
C
R
A
H
G
I
S
V
V
C
D
E
V
A
V
G
L
A
R
S
G
--
R
-
L
H
C
F
E
H
E
G
F
V
P
D
I
L
V
L
G
K
G
L
G
G
G
-
L
-
P
L
S
A
-
V
I
A
P
A
E
I
L
---
D
C
A
S
--
A
-
F
-------
A
-----
M
Q
-------
T
L
H
G
N
P
V
C
A
A
A
G
L
A
V
L
E
T
I
E
A
E
-
N
L
T
T
A
A
-
E
R
K
G
K
L
L
R
E
G
L
-
A
R
L
A
E
R
H
E
L
-----
I
G
D
I
R
G
--
R
G
L
A
C
G
V
E
L
V
R
N
R
Q
S
-----
R
-------
E
---
P
A
R
A
E
-------------------
T
A
K
L
I
Y
R
A
Y
E
L
G
L
V
L
Y
-
Y
--
V
G
M
N
--
G
-
N
V
L
E
M
T
P
P
L
T
M
T
E
D
E
V
R
H
A
V
N
L
L
D
Q
A
F
T
-----
53
Blastp_CBE
66.52
34%
-11
- C4 -
-
5M49
2
?
A:
[22-421]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
L
A
V
A
G
G
Q
G
A
R
L
V
E
E
---
D
G
R
E
L
I
D
L
S
--
G
AW
G
----
A
--
A
--
S
--
L
G
Y
G
H
---
P
A
I
I
E
A
V
S
R
A
A
A
NPA
G
A
S
I
L
S
A
S
---
N
-
A
----
P
---
A
-------------------
V
-
A
--
L
A
E
R
L
T
A
S
F
-
P
-R
G
-
T
H
K
---------------
V
W
F
G
H
S
G
S
D
A
N
E
A
A
Y
R
A
I
T
R
A
------
T
------
G
------
R
T
------
G
----
V
I
A
F
I
G
A
Y
H
G
C
T
---
V
G
S
M
---
A
F
---
S
---------------
K
--
A
--
D
----
G
--------
L
I
L
------
L
P
Y
--
P
D
P
Y
------------
R
-
P
----
Y
Q
---
D
--
D
P
---
T
G
--
D
----
A
----
V
L
A
L
---
L
K
E
-
R
L
A
A
V
P
A
G
S
--
I
A
A
A
F
I
E
P
I
-
Q
-
S
D
G
G
L
I
V
P
P
D
-
G
F
L
R
K
F
A
D
I
C
R
A
H
G
I
S
V
V
C
D
E
V
K
V
G
L
A
R
S
G
--
R
-
L
H
C
F
E
H
E
G
F
V
P
D
I
L
V
L
G
K
G
L
G
G
G
-
L
-
P
L
S
A
-
V
I
A
P
A
E
I
L
---
D
C
A
S
--
A
-
F
-------
A
-----
M
Q
-------
T
L
H
G
N
P
V
C
A
A
A
G
L
A
V
L
E
T
I
E
A
E
-
N
L
T
T
A
A
-
E
R
K
G
K
L
L
R
E
G
L
-
A
R
L
A
E
R
H
E
L
-----
I
G
D
I
R
G
--
R
G
L
A
C
G
V
E
L
V
R
N
R
Q
S
-----
R
-------
E
---
P
A
R
A
E
-------------------
T
A
K
L
I
Y
R
A
Y
E
L
G
L
V
L
Y
-
Y
--
V
G
M
N
--
G
-
N
V
L
E
M
T
P
P
L
T
M
T
E
D
E
V
R
H
A
V
N
L
L
D
Q
A
F
T
-----
81
Blastp_CBE
66.50
33%
-3
- C4 -
-
3DXW
4
ACLR_ACHOB
B:
[38-436]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
L
A
I
S
G
G
R
G
A
R
L
I
E
E
---
N
G
R
E
L
I
D
L
S
--
G
--
A
WGAA
S
--
L
--
G
--
Y
G
H
P
A
---
I
V
A
A
V
S
---------
A
A
A
A
N
P
A
G
---
A
-
T
----
I
---
L
S
--
A
S
------
N
----
A
P
A
V
-
T
--
L
A
E
R
L
L
A
S
F
-
P
G
-
E
G
T
H
K
---------------
I
W
F
G
H
S
G
S
D
A
N
E
A
A
Y
R
A
I
V
K
A
------
T
------
G
------
R
S
------
G
----
V
I
A
F
A
G
A
Y
H
G
C
T
---
V
G
S
M
---
A
F
---
S
-
G
--
H
-------------
A
--
D
----
G
--------
L
I
L
------
L
P
Y
--
P
D
P
Y
------------
R
-
P
----
Y
R
---
N
--
D
P
---
T
G
--
D
----
A
----
I
L
T
L
---
L
T
E
-
K
L
A
A
V
P
A
G
S
--
I
G
A
A
F
I
E
P
I
-
Q
-
S
D
G
G
L
I
V
P
P
D
-
G
F
L
R
K
F
A
D
I
C
R
A
H
G
I
L
V
V
C
D
E
V
K
V
G
L
A
R
S
G
--
R
-
L
H
C
F
E
H
E
G
F
V
P
D
I
L
V
L
G
K
G
L
G
G
G
-
L
-
P
L
S
A
-
V
I
A
P
A
E
I
L
---
D
C
A
S
--
A
-
F
-------
A
-----
M
Q
-------
T
L
H
G
N
P
I
S
A
A
A
G
L
A
V
L
E
T
I
D
R
D
-
D
L
P
A
M
A
-
E
R
K
G
R
L
L
R
D
G
L
-
S
E
L
A
K
R
H
P
L
-----
I
G
D
I
R
G
--
R
G
L
A
C
G
M
E
L
V
C
D
R
Q
S
-----
R
-------
E
---
P
A
R
A
E
-------------------
T
A
K
L
I
Y
R
A
Y
Q
L
G
L
V
V
Y
-
Y
--
V
G
M
N
--
G
-
N
V
L
E
F
T
P
P
L
T
I
T
E
T
D
I
H
K
A
L
D
L
L
D
R
A
F
S
-----
82
Blastp_CBE
66.46
33%
-4
- C4 -
-
2ZUK
4
ACLR_ACHOB
B:
[38-436]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
L
A
I
S
G
G
R
G
A
R
L
I
E
E
---
N
G
R
E
L
I
D
L
S
--
G
--
A
WGAA
S
--
L
--
G
--
Y
G
H
P
A
---
I
V
A
A
V
S
---------
A
A
A
A
N
P
A
G
---
A
-
T
----
I
---
L
S
--
A
S
------
N
----
A
P
A
V
-
T
--
L
A
E
R
L
L
A
S
F
-
P
G
-
E
G
T
H
K
---------------
I
W
F
G
H
S
G
S
D
A
N
E
A
A
Y
R
A
I
V
K
A
------
T
------
G
------
R
S
------
G
----
V
I
A
F
A
G
A
Y
H
G
C
T
---
V
G
S
M
---
A
F
---
S
-
G
--
H
-------------
A
--
D
----
G
--------
L
I
L
------
L
P
Y
--
P
D
P
Y
------------
R
-
P
----
Y
R
---
N
--
D
P
---
T
G
--
D
----
A
----
I
L
T
L
---
L
T
E
-
K
L
A
A
V
P
A
G
S
--
I
G
A
A
F
I
E
P
I
-
Q
-
S
D
G
G
L
I
V
P
P
D
-
G
F
L
R
K
F
A
D
I
C
R
A
H
G
I
L
V
V
C
D
E
V
K
V
G
L
A
R
S
G
--
R
-
L
H
C
F
E
H
E
G
F
V
P
D
I
L
V
L
G
K
G
L
G
G
G
-
L
-
P
L
S
A
-
V
I
A
P
A
E
I
L
---
D
C
A
S
--
A
-
F
-------
A
-----
M
Q
-------
T
L
H
G
N
P
I
S
A
A
A
G
L
A
V
L
E
T
I
D
R
D
-
D
L
P
A
M
A
-
E
R
K
G
R
L
L
R
D
G
L
-
S
E
L
A
K
R
H
P
L
-----
I
G
D
I
R
G
--
R
G
L
A
C
G
M
E
L
V
C
D
R
Q
S
-----
R
-------
E
---
P
A
R
A
E
-------------------
T
A
K
L
I
Y
R
A
Y
Q
L
G
L
V
V
Y
-
Y
--
V
G
M
N
--
G
-
N
V
L
E
F
T
P
P
L
T
I
T
E
T
D
I
H
K
A
L
D
L
L
D
R
A
F
S
-----
166
HHSearch
65.65
28%
1
- C4 -
-
4PPM
2
PIGE_SERSF
A:
[415-849]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
D
N
V
F
R
S
A
A
G
T
Q
L
Y
D
D
---
A
G
E
A
F
L
D
M
V
--
A
--
G
----
Y
GC
L
--
N
--
L
G
H
N
P
---
Q
P
V
V
N
A
---------
L
K
N
Y
L
D
A
Q
---
G
-
P
----
N
F--
I
Q
YI
S
I
------
P
----
E
Q
T
A
-
K
--
L
A
E
V
L
C
R
L
A
-
P
G
-
N
-
M
G
R
---------------
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
A
S
------
T
------
G
------
K
P
------
G
----
I
A
Y
L
R
N
S
Y
H
G
K
T
---
L
G
A
L
---
S
I
---
T
-
G
--
R
---
D
K
H
R
R
Y
F
T
--
P
L
L
D
----
A
--------
M
V
E
------
V
P
F
--
G
D
------------------------------------------------
L
A
A
L
---
R
E
A
-
L
-----
N
R
E
D
-
V
G
A
L
M
I
E
P
I
-
Q
-
G
E
G
G
V
H
I
P
P
A
-
G
Y
L
Q
A
V
Q
Q
L
C
R
E
T
G
V
L
L
M
V
D
E
V
Q
T
G
L
G
R
T
G
---
K
L
F
A
C
E
W
D
G
I
E
P
D
V
L
M
L
S
K
S
L
S
G
G
L
I
-
P
I
G
A
-
T
L
C
R
A
D
L
W
---
Q
K
A
Y
--
G
-
T
ADR----
F
-----
L
V
----
H
S
S
T
Y
G
G
G
N
L
A
S
V
V
A
L
S
A
L
R
E
I
L
A
Q
-
D
L
V
G
H
A
-
E
R
M
G
A
Y
F
K
Q
A
L
-
S
E
I
A
A
R
---
Y
P
F
--
V
S
E
V
R
G
--
R
G
L
M
L
G
I
Q
F
D
Q
A
---------H
T
T
W
K
F
-
L
---
P
D
P
V
Q
A
H
L
R
A
A
M
D
R
M
E
Q
A
L
G
E
M
F
C
M
K
F
V
T
K
L
C
Q
D
H
K
I
L
T
F
-
I
--
T
A
N
S
--
S
-
T
V
I
R
I
Q
P
P
L
I
I
S
K
A
E
I
D
R
F
V
G
A
F
A
T
V
C
E
E
L
S
--
156
HHSearch
65.62
26%
-13
- C4 -
-
5KR6
2
?
B:
[51-475]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
R
I
I
T
G
G
K
G
I
R
I
Q
D
S
---
E
G
R
E
Y
I
D
A
F
--
A
--
G
----
L
YC
V
--
N
--
V
G
Y
G
R
---
T
E
I
A
D
A
---------
I
Y
E
Q
A
K
E
L
---
A
-
Y
----
Y
HTY
V
G
--
H
S
------
N
----
E
P
I
I
-
E
--
L
S
E
R
I
I
R
E
W
A
P
A
-
G
-
M
S
K
---------------
V
Y
Y
G
M
S
G
S
D
A
N
E
T
Q
I
K
L
V
W
Y
Y
------
N
N
V
L
GRP
Q
------
K
K
------
K
----
I
I
S
R
Q
R
G
Y
H
G
S
G
---
I
M
T
G
---
S
L
---
T
-
G
--
L
---
P
A
F
H
N
H
F
D
--
L
P
L
E
----
P
--------
I
R
H
------
T
T
C
--
P
H
Y
Y
------------
R
-
A
----
P
A
---
G
--
M
S
---
E
A
--
E
F
S
R
H
C
----
A
D
E
L
---
E
K
M
-
I
L
A
--
E
G
P
D
T
-
V
A
A
F
I
G
E
P
V
-
M
-
G
T
G
G
I
V
P
P
P
E
-
G
Y
W
E
A
I
Q
A
V
L
N
K
Y
D
I
L
L
I
A
D
E
V
V
C
G
F
G
R
T
G
---
S
M
F
G
S
H
H
Y
G
M
K
P
D
L
I
T
V
A
K
G
L
T
S
A
Y
A
-
P
L
S
G
-
V
I
V
G
E
K
V
W
---
K
V
L
E
--
Q
-
G
S
D
Q
YG--
P
-----
I
G
----
H
G
W
T
Y
S
G
H
P
I
C
A
A
A
A
L
A
N
L
D
I
I
E
R
E
-
N
L
T
G
N
A
-
A
D
T
G
A
Y
F
Q
Q
R
M
-
R
E
T
F
G
D
---
H
P
L
--
V
G
E
V
R
G
--
V
G
L
M
A
A
L
E
F
V
A
D
K
D
K
-----
R
-------
T
RFD
P
S
L
K
V
-------------------
G
P
R
V
S
A
A
C
L
E
D
G
M
I
A
R
-
A
--
M
P
-
H
--
G
-
D
I
L
G
F
A
P
P
L
V
I
T
R
A
E
V
D
E
I
V
D
I
A
K
Q
A
V
D
A
V
A
--
165
HHSearch
63.41
28%
3
- C4 -
-
4PPM
2
PIGE_SERSF
B:
[415-849]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
D
N
V
F
R
S
A
A
G
T
Q
L
Y
D
D
---
A
G
E
A
F
L
D
M
V
--
A
--
G
----
Y
GC
L
--
N
--
L
G
H
N
P
---
Q
P
V
V
N
A
---------
L
K
N
Y
L
D
A
Q
---
G
-
P
----
N
F--
I
Q
YI
S
I
------
P
----
E
Q
T
A
-
K
--
L
A
E
V
L
C
R
L
A
-
P
G
-
N
-
M
G
R
---------------
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
A
S
------
T
------
G
------
K
P
------
G
----
I
A
Y
L
R
N
S
Y
H
G
K
T
---
L
G
A
L
---
S
I
---
T
-
G
--
R
---
D
K
H
R
R
Y
F
T
--
P
L
L
D
----
A
--------
M
V
E
------
V
P
F
--
G
D
------------------------------------------------
L
A
A
L
---
R
E
A
-
L
-----
N
R
E
D
-
V
G
A
L
M
I
E
P
I
-
Q
-
G
E
G
G
V
H
I
P
P
A
-
G
Y
L
Q
A
V
Q
Q
L
C
R
E
T
G
V
L
L
M
V
D
E
V
Q
T
G
L
G
R
T
G
---
K
L
F
A
C
E
W
D
G
I
E
P
D
V
L
M
L
S
K
S
L
S
G
G
L
I
-
P
I
G
A
-
T
L
C
R
A
D
L
W
---
Q
K
A
Y
--
G
-
T
ADR----
F
-----
L
V
----
H
S
S
T
Y
G
G
G
N
L
A
S
V
V
A
L
S
A
L
R
E
I
L
A
Q
-
D
L
V
G
H
A
-
E
R
M
G
A
Y
F
K
Q
A
L
-
S
E
I
A
A
R
---
Y
P
F
--
V
S
E
V
R
G
--
R
G
L
M
L
G
I
Q
F
D
-----------WHTTWKF
L
---
P
D
P
V
Q
AHLRAAMDRMEQALGEMFC
M
K
F
V
T
K
L
C
Q
D
H
K
I
L
T
F
-
I
--
T
A
N
S
--
S
-
T
V
I
R
I
Q
P
P
L
I
I
S
K
A
E
I
D
R
F
V
G
A
F
A
T
V
C
E
E
L
S
--
163
HHSearch
63.06
24%
-17
- C4 -
-
4UHO
13
?
A:
[53-467]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
R
I
I
V
A
A
E
G
S
W
L
V
D
D
---
K
G
R
R
I
Y
D
S
L
--
S
--
G
----
L
WT
C
--
G
--
A
G
H
S
R
---
K
E
I
A
D
A
---------
V
A
K
Q
I
G
T
L
---
D
-
Y
----
S
PG-
F
Q
--
Y
G
------
H
----
P
L
S
F
-
Q
--
L
A
E
K
I
A
Q
M
T
-
P
G
-
T
-
L
D
H
---------------
V
F
F
T
G
S
G
S
E
C
A
D
T
S
I
K
M
A
R
A
Y
------
W
R
I
K
GQA
Q
------
K
T
------
K
----
L
I
G
R
A
R
G
Y
H
G
V
N
---
V
A
G
T
---
S
L
---
G
-
G
--
I
---
G
G
N
R
K
M
F
G
--
P
L
-
M
----
D
--------
V
D
H
------
L
P
H
--
T
L
Q
P
------------
G
-
M
----
A
F
---
T
KG
A
A
ETG
G
V
--
E
----
L
----
A
N
E
L
---
L
K
L
-
I
E
L
--
H
D
A
S
N
-
I
A
A
V
I
V
E
P
M
-
S
-
G
S
A
G
V
I
V
P
P
K
-
G
Y
L
Q
R
L
R
E
I
C
D
A
N
D
I
L
L
I
F
D
E
V
I
T
A
F
G
R
M
G
---
K
A
T
G
A
E
Y
F
G
V
T
P
D
I
M
N
V
A
K
Q
V
T
N
G
A
V
-
P
M
G
A
-
V
I
A
S
S
E
I
Y
---
D
T
F
M
--
N
-
Q
NLPEYAV
E
-----
F
G
----
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
I
A
A
L
D
L
L
Q
K
E
-
N
L
I
Q
Q
S
-
A
E
L
A
P
H
F
E
K
A
L
-
H
G
L
K
G
T
----
K
N
--
V
I
D
I
R
N
--
C
G
L
A
G
A
I
Q
I
A
A
R
D
G
D
-----
A
-------------
I
V
R
-------------------
P
F
E
A
S
M
K
L
W
K
E
G
F
Y
V
R
-
F
--
G
G
------
D
T
L
Q
F
G
P
T
F
N
A
K
P
E
D
L
D
R
L
F
D
A
V
G
E
A
L
N
G
V
---
48
Blastp_CBE
62.53
35%
-5
- C4 -
-
1WKG
2
LYSJ_THET8
A:
[29-378]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
---
E
G
N
E
Y
I
D
C
V
--
G
--
G
YG--
V
--
A
--
N
--
L
G
H
G
N
---
P
E
V
V
E
A
---------
V
K
R
Q
A
E
T
L
---
M
-
A
----
M
---
P
Q
--
T
L
------
P
----
T
P
M
R
G
E
--
F
Y
R
T
L
T
A
I
L
-
P
P
-
E
-
L
N
R
---------------
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
------
T
------
G
------
R
K
------
K
----
F
V
A
A
M
R
G
F
S
G
R
T
M
--
G
S
L
S
---
V
T
---
W
-
E
--
P
---
K
Y
R
E
P
------------------------
F
------
L
P
L
--
V
E
P
V
------------
E
-
F
----
I
P
---
Y
--
N
D
---
V
E
--
A
----
L
----
K
R
A
V
---
D
-----------
E
E
-
T
A
A
V
I
L
E
P
V
-
Q
-
G
E
G
G
-
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
--
K
-
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
-
A
V
M
R
E
E
V
A
---
R
S
M
P
--
K
-
G
--------------
G
----
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
-
R
L
W
E
R
A
-
A
E
L
G
P
W
F
---
M
-
E
K
L
R
A
I
P
--
S
P
K
--
I
R
E
V
R
G
--
M
G
L
M
V
G
L
E
L
K
E
K
A
A
------------------
P
Y
I
A
R
-------------------
L
E
------
K
E
H
R
V
L
A
L
-
Q
--
A
G
P
-----
T
V
I
R
F
L
P
P
L
V
I
----------------------
176
HHSearch
62.33
27%
-23
- C4 -
-
4JF1
6
ARGD_SALTY
A:
[39-419]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
---
Q
G
K
E
Y
I
D
F
A
--
G
--
G
----
I
AV
T
--
A
--
L
G
H
C
H
---
P
A
L
V
E
A
---------
L
K
S
Q
G
E
T
L
---
W
-
H
----
T
S--
N
V
--
F
T
------
N
----
E
P
A
L
-
R
--
L
G
R
K
L
I
D
A
T
-
F
----
A
E
R
---------------
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
------
A
C
V
R
HSP
F
------
K
T
------
K
----
I
I
A
F
H
N
A
F
H
G
Q
S
---
L
F
T
V
---
S
V
---
G
-
G
--
Q
---
P
K
Y
S
D
G
F
G
--
P
K
P
A
----
D
--------
I
I
H
------
V
P
F
--
N
D
------------------------------------------------
L
H
A
V
---
K
A
V
----
M
D
---
D
H
-
T
C
A
V
V
V
E
P
I
-
Q
-
G
E
G
G
V
Q
A
A
T
P
-
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
---
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
E
I
A
---
S
A
F
---------------------------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
-
E
V
L
Q
G
I
-
H
T
K
R
Q
Q
F
V
Q
H
L
-
Q
A
I
D
E
Q
---
F
D
I
--
F
S
D
I
R
G
--
M
G
L
L
I
G
A
E
L
K
P
K
Y
K
---------------------
G
R
-------------------
A
R
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
-
N
--
A
G
A
-----
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
--
134
Fugue
62.22
23%
-4
- C4 -
-
2GSA
2
GSA_SYNP6
A:
[6-432]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
PGGV
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
---
D
G
N
R
Y
I
D
Y
V
--
G
--
T
----
W
--
G
--
P
AI
C
G
H
A
H
---
P
E
V
I
E
A
---------
L
K
V
A
M
E
K
----
G
-
T
----
S
---
F
G
--
A
P
------
C
----
A
L
E
N
-
V
--
L
A
E
M
V
N
D
A
V
-
P
S
---
I
E
M
---------------
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
------
T
------
G
------
R
D
------
K
----
I
I
K
F
E
G
C
Y
H
G
H
A
---
D
M
F
L
---
V
K
---
A
-
G
--
S
---
G
V
A
T
L
G
L
P
-----------------------------
S
S
--
P
G
V
P
------------
K
-
K
----
T
T
---
A
--
N
T
---
L
T
--
T
----
P
----
Y
N
D
L
---
E
A
V
-
K
A
L
F
A
E
N
P
G
E
-
I
A
G
V
I
L
E
P
I
-
V
-
G
N
S
G
F
I
V
P
D
A
-
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
--
Y
G
G
-
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
-
L
-
P
V
G
A
-
Y
G
G
K
R
E
I
M
---
Q
L
V
A
P-
A
-
G
-------
P
-----
M
Y
----
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
-
D
Q
I
T
K
R
L
S
D
G
L
-
L
A
I
A
Q
E
T
G
H
A
A
C
--
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
-----
K
-------
K
---
S
D
L
Q
K
-------------------
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
-
P
--
S
Q
F
E
--
A
-
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
-------
46
Blastp_CBE
61.94
35%
-6
- C4 -
-
1WKH
2
LYSJ_THET8
A:
[29-378]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
---
E
G
N
E
Y
I
D
C
V
--
G
--
G
YG--
V
--
A
--
N
--
L
G
H
G
N
---
P
E
V
V
E
A
---------
V
K
R
Q
A
E
T
L
---
M
-
A
----
M
---
P
Q
--
T
L
------
P
----
T
P
M
R
G
E
--
F
Y
R
T
L
T
A
I
L
-
P
P
-
E
-
L
N
R
---------------
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
------
T
------
G
------
R
K
------
K
----
F
V
A
A
M
R
G
F
S
G
R
T
M
--
G
S
L
S
---
V
T
---
W
-
E
--
P
---
K
Y
R
E
P
------------------------
F
------
L
P
L
--
V
E
P
V
------------
E
-
F
----
I
P
---
Y
--
N
D
---
V
E
--
A
----
L
----
K
R
A
V
---
D
-----------
E
E
-
T
A
A
V
I
L
E
P
V
-
Q
-
G
E
G
G
-
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
--
K
-
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
-
A
V
M
R
E
E
V
A
---
R
S
M
P
--
K
-
G
--------------
G
----
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
-
R
L
W
E
R
A
-
A
E
L
G
P
W
F
---
M
-
E
K
L
R
A
I
P
--
S
P
K
--
I
R
E
V
R
G
--
M
G
L
M
V
G
L
E
L
K
E
K
A
A
------------------
P
Y
I
A
R
-------------------
L
E
------
K
E
H
R
V
L
A
L
-
Q
--
A
G
P
-----
T
V
I
R
F
L
P
P
L
V
I
----------------------
45
Blastp_CBE
61.57
35%
-5
- C4 -
-
1WKH
2
LYSJ_THET8
B:
[29-378]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
---
E
G
N
E
Y
I
D
C
V
--
G
--
G
YG--
V
--
A
--
N
--
L
G
H
G
N
---
P
E
V
V
E
A
---------
V
K
R
Q
A
E
T
L
---
M
-
A
----
M
---
P
Q
--
T
L
------
P
----
T
P
M
R
G
E
--
F
Y
R
T
L
T
A
I
L
-
P
P
-
E
-
L
N
R
---------------
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
------
T
------
G
------
R
K
------
K
----
F
V
A
A
M
R
G
F
S
G
R
T
M--
G
S
L
S
---
V
T
---
W
-
E
--
P
---
K
Y
R
E
P
------------------------
F
------
L
P
L
--
V
E
P
V
------------
E
-
F
----
I
P
---
Y
--
N
D
---
V
E
--
A
----
L
----
K
R
A
V
---
D
-----------
E
E
-
T
A
A
V
I
L
E
P
V
-
Q
-
G
E
G
G
-
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
--
K
-
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
-
A
V
M
R
E
E
V
A
---
R
S
M
P
--
K
-
G
--------------
G
----
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
-
R
L
W
E
R
A
-
A
E
L
G
P
W
F
---
M
-
E
K
L
R
A
I
P
--
S
P
K
--
I
R
E
V
R
G
--
M
G
L
M
V
G
L
E
L
K
E
K
A
A
------------------
P
Y
I
A
R
-------------------
L
E
------
K
E
H
R
V
L
A
L
-
Q
--
A
G
P
-----
T
V
I
R
F
L
P
P
L
V
I
----------------------
49
Blastp_CBE
61.46
35%
-5
- C4 -
-
1VEF
2
LYSJ_THET8
B:
[29-378]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
---
E
G
N
E
Y
I
D
C
V
--
G
--
G
YG--
V
--
A
--
N
--
L
G
H
G
N
---
P
E
V
V
E
A
---------
V
K
R
Q
A
E
T
L
---
M
-
A
----
M
---
P
Q
--
T
L
------
P
----
T
P
M
R
G
E
--
F
Y
R
T
L
T
A
I
L
-
P
P
-
E
-
L
N
R
---------------
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
------
T
------
G
------
R
K
------
K
----
F
V
A
A
M
R
G
F
S
G
R
T
M--
G
S
L
S
---
V
T
---
W
-
E
--
P
---
K
Y
R
E
P
------------------------
F
------
L
P
L
--
V
E
P
V
------------
E
-
F
----
I
P
---
Y
--
N
D
---
V
E
--
A
----
L
----
K
R
A
V
---
D
-----------
E
E
-
T
A
A
V
I
L
E
P
V
-
Q
-
G
E
G
G
-
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
--
K
-
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
-
A
V
M
R
E
E
V
A
---
R
S
M
P
--
K
-
G
--------------
G
----
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
-
R
L
W
E
R
A
-
A
E
L
G
P
W
F
---
M
-
E
K
L
R
A
I
P
--
S
P
K
--
I
R
E
V
R
G
--
M
G
L
M
V
G
L
E
L
K
E
K
A
A
------------------
P
Y
I
A
R
-------------------
L
E
------
K
E
H
R
V
L
A
L
-
Q
--
A
G
P
-----
T
V
I
R
F
L
P
P
L
V
I
----------------------
50
Blastp_CBE
61.25
35%
-4
- C4 -
-
1VEF
2
LYSJ_THET8
A:
[29-378]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
---
E
G
N
E
Y
I
D
C
V
--
G
--
G
YG--
V
--
A
--
N
--
L
G
H
G
N
---
P
E
V
V
E
A
---------
V
K
R
Q
A
E
T
L
---
M
-
A
----
M
---
P
Q
--
T
L
------
P
----
T
P
M
R
G
E
--
F
Y
R
T
L
T
A
I
L
-
P
P
-
E
-
L
N
R
---------------
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
------
T
------
G
------
R
K
------
K
----
F
V
A
A
M
R
G
F
S
G
R
T
M
--
G
S
L
S
---
V
T
---
W
-
E
--
P
---
K
Y
R
E
P
------------------------
F
------
L
P
L
--
V
E
P
V
------------
E
-
F
----
I
P
---
Y
--
N
D
---
V
E
--
A
----
L
----
K
R
A
V
---
D
-----------
E
E
-
T
A
A
V
I
L
E
P
V
-
Q
-
G
E
G
G
-
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
--
K
-
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
-
A
V
M
R
E
E
V
A
---
R
S
M
P
--
K
-
G
--------------
G
----
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
-
R
L
W
E
R
A
-
A
E
L
G
P
W
F
---
M
-
E
K
L
R
A
I
P
--
S
P
K
--
I
R
E
V
R
G
--
M
G
L
M
V
G
L
E
L
K
E
K
A
A
------------------
P
Y
I
A
R
-------------------
L
E
------
K
E
H
R
V
L
A
L
-
Q
--
A
G
P
-----
T
V
I
R
F
L
P
P
L
V
I
----------------------
47
Blastp_CBE
61.04
35%
-4
- C4 -
-
1WKG
2
LYSJ_THET8
B:
[29-378]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
---
E
G
N
E
Y
I
D
C
V
--
G
--
G
YG--
V
--
A
--
N
--
L
G
H
G
N
---
P
E
V
V
E
A
---------
V
K
R
Q
A
E
T
L
---
M
-
A
----
M
---
P
Q
--
T
L
------
P
----
T
P
M
R
G
E
--
F
Y
R
T
L
T
A
I
L
-
P
P
-
E
-
L
N
R
---------------
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
------
T
------
G
------
R
K
------
K
----
F
V
A
A
M
R
G
F
S
G
R
T
M--
G
S
L
S
---
V
T
---
W
-
E
--
P
---
K
Y
R
E
P
------------------------
F
------
L
P
L
--
V
E
P
V
------------
E
-
F
----
I
P
---
Y
--
N
D
---
V
E
--
A
----
L
----
K
R
A
V
---
D
-----------
E
E
-
T
A
A
V
I
L
E
P
V
-
Q
-
G
E
G
G
-
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
--
K
-
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
-
A
V
M
R
E
E
V
A
---
R
S
M
P
--
K
-
G
--------------
G
----
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
-
R
L
W
E
R
A
-
A
E
L
G
P
W
F
---
M
-
E
K
L
R
A
I
P
--
S
P
K
--
I
R
E
V
R
G
--
M
G
L
M
V
G
L
E
L
K
E
K
A
A
------------------
P
Y
I
A
R
-------------------
L
E
------
K
E
H
R
V
L
A
L
-
Q
--
A
G
P
-----
T
V
I
R
F
L
P
P
L
V
I
----------------------
174
HHSearch
58.29
23%
-30
- C4 -
-
4AO9
2
BFAT_VARPD
A:
[69-447]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
---
D
G
H
R
Y
A
D
F
I
--
A
--
E
----
Y
TA
G
--
V
--
Y
G
H
S
A
---
P
E
I
R
D
A
---------
V
I
E
A
M
Q
G
G
---
I
------
N
---
L
T
--
G
H
------
N
----
L
L
E
G
-
R
--
L
A
R
L
I
C
E
R
F
-
P
Q
---
I
E
Q
---------------
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
------
T
------
G
------
R
R
------
K
----
I
V
V
F
S
G
G
Y
H
G
G
V
---
L
G
F
G
---
A
R
---
P
-
S
--
P
---
T
T
---------
V
P
F
----
D
--------
F
--------
L
V
L
--
P
-----------------------
Y
--------------------------
N
D
A
---
Q
T
A
-
R
A
Q
I
E
R
H
G
P
E
-
I
A
V
V
L
V
E
P
M
-
Q
-
G
A
S
G
C
I
P
G
Q
P
-
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
--
R
L
A
---
P
H
G
L
A
N
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
-
M
-
S
F
G
A
-
F
G
G
R
A
D
V
M
---
A
L
F
D
--
P
-
R
TG-----
P
-----
L
A
----
H
S
G
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F
T
P
-
E
A
A
G
A
L
-
A
E
R
G
E
A
L
R
A
R
L
-
N
A
L
C
A
N
---
E
G
V
--
A
M
Q
F
T
G
--
I
G
S
L
M
N
A
H
F
V
Q
G
D
V
R
SSEDL
A
-------
A
---
V
D
G
R
L
-------------------
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
-
P
--
R
G
-------
F
V
V
L
--
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
I
G
S
F
I
G
G
H
G
--
98
Blastp_CBE
52.62
32%
-11
- C4 -
-
2ZSL
1
GSA_AERPE
A:
[39-377]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
---
D
G
A
R
I
V
D
L
V
LA
Y
--
G
----
P
--
L
--
I
--
L
G
H
K
H
---
P
R
V
L
E
A
---------
V
E
E
A
L
A
R
----------------
G
--
W
L
------
Y
GAPG
E
A
E
V
-
L
--
L
A
E
K
I
L
G
Y
V
-
K
R
-
G
--
G
M
---------------
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
------
T
------
G
------
R
D
------
L
----
I
L
K
F
D
G
C
Y
H
G
S
H
---
D
A
V
L
VAA
G
---------------
G
V
P
T
S
A
--
G
V
P
E
----
A
--------
V
A
R
------
L
T
L
--
V
T
P
Y
---------------------------
N
D
--------------------
V
---
E
A
L
-
E
R
V
F
A
E
Y
G
D
R
-
I
A
G
V
I
V
E
P
V
-
I
-
A
N
A
G
V
I
P
P
R
R
-
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
LE
G
A
Q
G
Y
F
N
I
E
G
---
D
I
I
V
L
G
K
I
I
G
G
G
-
F
-
P
V
G
A
-
V
A
G
S
R
E
V
M
---
S
L
L
T
P-
Q
-
G
-------
K
-----
V
F
----
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
E
-
P
V
Y
S
V
S
-
R
E
A
A
K
A
L
E
E
A
A
-
S
E
V
L
D
R
T
G
L
P
Y
T
--
I
N
R
V
E
S
M
-
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
-----
A
-------
R
----------------------------------------------------------------------------------------
99
Blastp_CBE
52.59
32%
-11
- C4 -
-
2EPJ
1
GSA_AERPE
A:
[39-377]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
---
D
G
A
R
I
V
D
L
V
LA
Y
--
G
----
P
--
L
--
I
--
L
G
H
K
H
---
P
R
V
L
E
A
---------
V
E
E
A
L
A
R
----------------
G
--
W
L
------
Y
GAPG
E
A
E
V
-
L
--
L
A
E
K
I
L
G
Y
V
-
K
R
-
G
--
G
M
---------------
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
------
T
------
G
------
R
D
------
L
----
I
L
K
F
D
G
C
Y
H
G
S
H
---
D
A
V
L
VAA
G
---------------
G
V
P
T
S
A
--
G
V
P
E
----
A
--------
V
A
R
------
L
T
L
--
V
T
P
Y
---------------------------
N
D
--------------------
V
---
E
A
L
-
E
R
V
F
A
E
Y
G
D
R
-
I
A
G
V
I
V
E
P
V
-
I
-
A
N
A
G
V
I
P
P
R
R
-
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
LE
G
A
Q
G
Y
F
N
I
E
G
---
D
I
I
V
L
G
K
I
I
G
G
G
-
F
-
P
V
G
A
-
V
A
G
S
R
E
V
M
---
S
L
L
T
P-
Q
-
G
-------
K
-----
V
F
----
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
E
-
P
V
Y
S
V
S
-
R
E
A
A
K
A
L
E
E
A
A
-
S
E
V
L
D
R
T
G
L
P
Y
T
--
I
N
R
V
E
S
M
-
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
-----
A
-------
R
----------------------------------------------------------------------------------------
100
Blastp_CBE
52.51
32%
-15
- C4 -
-
2E7U
2
GSA_THET8
A:
[30-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
G
G
T
P
P
F
L
V
R
G
E
G
A
Y
V
W
D
A
---
D
G
N
R
Y
L
D
Y
V
--
M
--
S
WG--
P
--
L
--
I
--
L
G
H
A
H
---
P
K
V
----------------
L
A
R
V
---
R
-
E
----
T
--------
L
------
E
----
R
G
L
T
-
F
--
G
A
--------
P
S
-
P
-
L
E
V
A
L
A
K
K
V
K
R
A
Y
PFVD
L
V
R
F
V
N
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
------
T
------
G
------
R
P
------
Y
----
I
V
K
F
R
G
N
Y
H
G
H
A
D--
G
L
L
V
---
E
A
---
G
-
S
GA
L
---
T
L
G
V
P
S
S
A
--
G
V
P
E
EYAK
L
--------
T
L
V
------
L
E
Y
--
N
D
P
------------------------------------------------------
E
G
L
-
R
E
V
L
K
R
R
G
E
E
-
I
A
A
I
I
F
E
P
V
-
V
-
G
N
A
G
V
L
V
P
T
E
-
D
F
L
K
A
L
H
-
E
A
K
A
Y
G
V
L
L
I
A
D
E
V
M
T
G
F
-
R
L
A
--
F
G
-
G
A
T
E
L
L
G
L
K
P
D
L
V
T
L
G
K
I
L
G
G
G
-
L
-
P
A
A
A
-
Y
A
G
R
R
E
I
M
---
E
K
V
A
--
P
L
G
-------
P
-----
V
Y
----
Q
A
G
T
L
S
G
N
P
L
A
M
A
A
G
L
A
T
L
E
L
L
E
E
N
P
G
Y
Y
A
Y
L
-
E
D
L
G
A
R
L
E
A
G
L
-
K
E
V
L
K
E
K
G
L
P
H
T
--
V
N
R
V
-----
G
S
M
I
T
V
F
F
T
E
G
P
V
V
-----
T
-------
F
---
Q
D
A
R
R
-------------------
T
------------------------------------------------------------
95
Blastp_CBE
51.99
32%
-12
- C4 -
-
2ZSM
2
GSA_AERPE
C:
[39-377]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
---
D
G
A
R
I
V
D
L
V
LA
Y
--
G
----
P
--
L
--
I
--
L
G
H
K
H
---
P
R
V
L
E
A
---------
V
E
E
A
L
A
R
----------------
G
--
W
L
------
Y
GAPG
E
A
E
V
-
L
--
L
A
E
K
I
L
G
Y
V
-
K
R
-
G
--
G
M
---------------
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
------
T
------
G
------
R
D
------
L
----
I
L
K
F
D
G
C
Y
H
G
S
H
---
D
A
V
L
VAA
G
---------------
G
V
P
T
S
A
--
G
V
P
E
----
A
--------
V
A
R
------
L
T
L
--
V
T
P
Y
---------------------------
N
D
--------------------
V
---
E
A
L
-
E
R
V
F
A
E
Y
G
D
R
-
I
A
G
V
I
V
E
P
V
-
I
-
A
N
A
G
V
I
P
P
R
R
-
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
LE
G
A
Q
G
Y
F
N
I
E
G
---
D
I
I
V
L
G
K
I
I
G
G
G
-
F
-
P
V
G
A
-
V
A
G
S
R
E
V
M
---
S
L
L
T
P-
Q
-
G
-------
K
-----
V
F
----
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
E
-
P
V
Y
S
V
S
-
R
E
A
A
K
A
L
E
E
A
A
-
S
E
V
L
D
R
T
G
L
P
Y
T
--
I
N
R
V
E
S
M-
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
-----
A
-------
R
----------------------------------------------------------------------------------------
96
Blastp_CBE
51.95
32%
-10
- C4 -
-
2ZSM
2
GSA_AERPE
B:
[39-377]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
---
D
G
A
R
I
V
D
L
V
LA
Y
--
G
----
P
--
L
--
I
--
L
G
H
K
H
---
P
R
V
L
E
A
---------
V
E
E
A
L
A
R
----------------
G
--
W
L
------
Y
GAPG
E
A
E
V
-
L
--
L
A
E
K
I
L
G
Y
V
-
K
R
-
G
--
G
M
---------------
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
------
T
------
G
------
R
D
------
L
----
I
L
K
F
D
G
C
Y
H
G
S
H
---
D
A
V
L
VAA
G
---------------
G
V
P
T
S
A
--
G
V
P
E
----
A
--------
V
A
R
------
L
T
L
--
V
T
P
Y
---------------------------
N
D
--------------------
V
---
E
A
L
-
E
R
V
F
A
E
Y
G
D
R
-
I
A
G
V
I
V
E
P
V
-
I
-
A
N
A
G
V
I
P
P
R
R
-
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
LE
G
A
Q
G
Y
F
N
I
E
G
---
D
I
I
V
L
G
K
I
I
G
G
G
-
F
-
P
V
G
A
-
V
A
G
S
R
E
V
M
---
S
L
L
T
P-
Q
-
G
-------
K
-----
V
F
----
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
E
-
P
V
Y
S
V
S
-
R
E
A
A
K
A
L
E
E
A
A
-
S
E
V
L
D
R
T
G
L
P
Y
T
--
I
N
R
V
E
S
M
-
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
-----
A
-------
R
----------------------------------------------------------------------------------------
97
Blastp_CBE
51.74
32%
-11
- C4 -
-
2ZSM
1
GSA_AERPE
A:
[39-377]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
---
D
G
A
R
I
V
D
L
V
LA
Y
--
G
----
P
--
L
--
I
--
L
G
H
K
H
---
P
R
V
L
E
A
---------
V
E
E
A
L
A
R
----------------
G
--
W
L
------
Y
GAPG
E
A
E
V
-
L
--
L
A
E
K
I
L
G
Y
V
-
K
R
-
G
--
G
M
---------------
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
------
T
------
G
------
R
D
------
L
----
I
L
K
F
D
G
C
Y
H
G
S
H
---
D
A
V
L
VAA
G
---------------
G
V
P
T
S
A
--
G
V
P
E
----
A
--------
V
A
R
------
L
T
L
--
V
T
P
Y
---------------------------
N
D
--------------------
V
---
E
A
L
-
E
R
V
F
A
E
Y
G
D
R
-
I
A
G
V
I
V
E
P
V
-
I
-
A
N
A
G
V
I
P
P
R
R
-
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
LE
G
A
Q
G
Y
F
N
I
E
G
---
D
I
I
V
L
G
K
I
I
G
G
G
-
F
-
P
V
G
A
-
V
A
G
S
R
E
V
M
---
S
L
L
T
P-
Q
-
G
-------
K
-----
V
F
----
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
E
-
P
V
Y
S
V
S
-
R
E
A
A
K
A
L
E
E
A
A
-
S
E
V
L
D
R
T
G
L
P
Y
T
--
I
N
R
V
E
S
M
-
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
-----
A
-------
R
----------------------------------------------------------------------------------------
104
Blastp_CBE
49.52
31%
-38
- C4 -
-
2CFB
1
GSA_THEEB
A:
[19-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
V
F
D
H
V
K
G
A
H
I
W
D
V
---
D
G
N
Q
Y
I
D
Y
V
--
G
--
S
WG--
P
--
A
--
I
--
V
G
H
A
H
---
P
E
V
I
D
A
------------
L
H
A
A
L
---
E
-
K
----
G
---
T
S
--
F
G
------
A
----
P
C
L
L
-
E
N
I
L
A
E
M
V
I
A
A
V
-
P
S
---
V
E
M
---------------
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
------
T
------
Q
------
R
E
------
K
----
V
I
K
F
E
G
C
Y
H
G
H
A
---------------------------------------------------------------------------------------------
A
--
T
L
---
T
A
--
P
----
Y
----
N
D
-
L
---
E
A
V
-
S
R
L
F
E
Q
Y
P
N
D
-
I
A
G
V
I
L
E
P
V
-
V
-
G
N
A
G
F
I
P
P
D
A
-
G
F
L
E
G
L
R
E
L
T
K
Q
Y
G
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
--
Y
G
-
G
A
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
V
I
G
G
G
-
L
-
P
V
G
A
-
Y
G
G
R
A
E
I
M
---
K
M
V
A
P-
A
-
G
-------
P
--------------
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
I
L
S
R
P
-
G
S
Y
E
H
L
D
R
I
T
G
K
L
V
Q
G
L
L
-
D
------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
42.68
31%
-2
- C4 -
-
3BS8
1
GSA_BACSU
A:
[44-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
M
E
R
G
K
G
S
K
I
F
D
I
---
D
G
N
E
Y
I
D
Y
V
--
L
--
S
WG--
P
--
L
--
I
--
L
G
H
T
N
---
D
R
V
V
E
S
----------
L
K
K
V
A
E
Y
---
G
-
T
----
S
---
F
G
--
A
P
------
T
----
E
V
E
N
-
E
--
L
A
K
L
V
I
D
R
V
-
P
S
---
V
E
I
---------------
V
R
M
V
S
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
------
T
------
G
------
R
N
------
K
----
I
L
K
F
E
G
C
Y
H
G
H
G
---
D
S
L
L
---
I
K
---
A
-
G
--
S
GVA
T
L
G
L
P
D
S
P
--
G
V
P
E
----
G
--------
I
A
K
------
N
T
I
--
T
V
P
Y
------------
N
-----------------------------------
D
L
---
E
S
V
-
K
L
A
F
Q
Q
F
G
E
D
-
I
A
G
V
I
V
E
P
V
-
A
-
G
N
M
G
V
V
P
P
Q
E
-
G
F
L
Q
G
L
R
D
I
T
E
Q
Y
G
S
L
L
I
F
D
E
V
M
T
G
F
-
R
V
---
D
Y
N
C
A
Q
G
Y
F
G
V
T
P
D
L
T
C
L
G
K
V
I
G
G
G
-
L
-
P
V
G
A
-
Y
G
G
K
A
E
I
M
---
E
Q
I
A
P-
S
-
G
-------
P
-----
I
Y
----
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
L
E
T
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------