@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : A9GR62_SORC5: (2019-01-26 )
MEAARETRLPCAAMAILTPLSLADARRIGALYGLEIADVRGLLAGSVNSNFALTLADGRGQVFLRVYEEQQLGAASREARMLEHLAAGGVATPQPLRRRDAAPSDTDAASDGAAFVAEHAGKPVALFPWVGGASLCQARVTPDATRRVGAALARVHLVGASFEGANASRFDLDGLDQRLRGLRSPAGARSTAPAPALPPDVAAAVDELTGRLERIRAAAPRTPGPQTLIHGDLFRDNVLWEAGEISALLDFESASRGSAAFDLAVTMLAWCFGDDLDPDLVSALAAGYTAVRPLSTEERDRLFHESVIAALRFSITRITDFELRPKGSGVYKDFRRFLARQRTLERLGPEGLLALLGV
Atome Classification :
(22 SA)
--------.........10........20........30.-.------..--.-.--...40........50......-------.-------.60........-.70-.---.--...-....80.-.....-.-.90-.-.......100.......110.......----120.......130-.-......-----------140-...--.....150.....------..160...--.-.--.-.--170----.......180--......-------.-190..-..-..--.200-.----.---...---....210..---...-----.-----.---220-.........230.......240--.---......250.......260.......270--------------------..--------------.--.---------------.-----..280-........290..------.......300.........310.......320----..----...-...330--..----.......340.......350......------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------MEAARETRL
P
C
A
A
M
A
I
LTP
L
S
L
A
D
A
R
R
I
G
A
-
L
-Y------
G
L
--
E
-
I
--
A
D
V
R
G
L
LAGSVNS
N
F
A
L
T
LAD-------G-------R
G
-
Q
V
F
L
R
V
Y
E
-
E
Q
--Q---L--GA
A
-
S
R
E
A
R
M
L
-
E
H
L
AA-G-GVA-T-P
Q
P
L
R
RRDAAPSDTDAASD
G
A
A
F
V
A
E
H----AGK
P
V
A
L
F
PWVG
G
-
A
-
S
L
C
QAR-----------V-T-
P
D
A
--
T
R
R
V
G
A
A
L
A
R
V
H
L
------VGASFEGA--N-A--S-R--FD
L
----
D
G
L
D
Q
R
L
R
G
L--RSPAGA-------R-STAPA-PA-LP--
P
D
---
V
----
A
---
A
A
V
---
D
E
L
T
G
R
L
E
R
---
I
R
A-----A-----A---P---RTPGPQ
T
L
I
H
G
D
LFRDNVLWEA--G---
E
I
S
A
L
L
DFESASRGS
A
A
F
D
L
A
V
T
M
L
A
W
C
F--------------------GD--------------D--L---------------
D
-----
P
D
L
V
--
S
A
L
A
A
G
Y
T
A--VR------PL
S
T
E
E
R
D
--
R
L
F
H
E
S
V
I
A
A
L
R
F
S
I
T
R
I
T
D
F
-----
E
L----RPK-GS
G
V
----
Y
K
----
D
F
R
R
F
L
A
R
Q
R
T
L
E
RL
G
P
E
G
L
L
A
L
LGV------------------
57
HHSearch
89.94
31%
-40
- C4 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-312]
-------------------------
T
D
I
T
E
D
E
L
R
N
F
L
T
-
Q
-
Y
------
D
V
G-
S
-
L
--
T
S
Y
K
G
I
A
E
---
N
S
N
F
L
L
H
T
T
----------------
K
D
-
P
L
I
L
T
L
Y
E
-
K
-------
K
--
N
D
L
-
P
F
F
L
G
L
M
-
Q
H
L
A
A
-
K
-
G
L
S
-
C
-
P
L
P
L
P
R
K
-----------
D
G
-
E
L
L
G
E
L
----
S
G
R
P
A
A
L
I
S
F
L
E
G
-
M
-
W
L
R
K
-------------
P
-
E
-
A
K
H
--
C
R
E
V
G
K
A
L
A
A
M
H
L
------
A
S
E
G
F
E
I
K
--
R
-
P
--
N
-
A
--
L
S
V
----
D
G
W
K
V
L
W
D
K
S
--
E
E
R
A
D
-----------------------
E
V
---
E
----
K
---
G
L
R
---
E
E
I
R
P
E
I
D
Y
---
L
A
A
-----
H
-----
W
-------
P
K
D
L
P
A
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
--
D
---
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
A
W
C
F
--------------------
E
K
DG------------
A
--
Y
---------------
N
-----
V
T
K
G
--
K
A
L
L
E
G
Y
Q
S
--
V
R
------
P
L
S
E
A
E
L
E
--
A
L
P
L
L
S
R
G
S
A
L
R
F
F
L
T
R
L
Y
D
W
-----
L
T
----
T
P
A
-
G
A
L
V
V---
K
K
----
D
P
L
E
Y
L
R
K
L
R
F
H
R
T
I
A
----------------------------
1
PsiBlast_PDB
89.47
29%
-40
- C4 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-319]
-------------------------
T
D
I
T
E
D
E
L
R
N
F
L
T
-
Q
-
Y
------
D
V
G-
S
-
L
--
T
S
Y
K
G
I
A
E
---
N
S
N
F
L
L
H
T
T
----------------
K
D
-
P
L
I
L
T
L
Y
E
-
K
-------
K
--
N
D
L
-
P
F
F
L
G
L
M
-
Q
H
L
A
A
-
K
-
G
L
S
-
C
-
P
L
P
L
P
R
K
D
G
E
------------
L
L
G
E
L
----
S
G
R
P
A
A
L
I
S
F
L
E
G
-
M
-
W
L
R
K
-----------------
P
E
A
K
H
C
R
E
V
G
K
A
L
A
A
M
H
L
------
A
S
E
G
F
E
I
K
--
R
-
P
--
N
-
A
--
L
S
V
----
D
G
W
----
K
V
L
--
W
D
K
S
E
E
-------
R
-
A
D
E
V
E
-
K
G
-
L
R
--
E
E
---
I
----
R
---
P
E
I
---
D
Y
L
A
----------
A
-----
H
-----
W
---
P
---
K
D
L
-
P
A
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
--
D
---
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
A
W
C
F
--------------------
E
K
--------------
D
--
G
---------------
A
-----
Y
N
V
T
K
G
K
A
L
L
E
G
Y
Q
S
--
V
R
------
P
L
S
E
A
E
L
E
--
A
L
P
L
L
S
R
G
S
A
L
R
F
F
L
T
R
L
Y
D
W
-----
L
T
----
T
P
A
-
G
A
L
V
----
V
K
KD
P
L
E
Y
L
R
K
L
R
F
H
R
T
I
A
N
V
A
E
Y
G
L
------------------------
31
Fugue
88.20
30%
-33
- C4 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
-------------------------
T
D
I
T
E
D
E
L
R
N
F
L
T
-
Q
-
Y
------
D
V
--
G
-----
S
L
T
S
Y
K
G
I
A
E
N
S
N
F
L
L
H
T
T
K
-------
D
-------
P
---
L
I
L
T
L
Y
E
-
K
K
--
N
--------
D
-
L
P
F
F
L
G
L
M
Q
H
L
A
A
-
K
-
G
L
S
-
C
-
P
L
P
L
P
R
K
D
G
E
L
------------
L
G
E
L
----
S
G
R
P
A
A
L
I
S
F
L
E
G
M
W
-
L
R
---
K
-----------
P
-
E
-
A
K
H
--
C
R
E
V
G
K
A
L
A
A
M
H
L
------
A
S
E
G
F
E
I
K
--
R
-
P
--
N
-
A
--
L
S
V
----
D
G
W
K
V
L
W
D
K
S
--
E
E
R
A
D
E
-------
V
-
E
K
G
L
R
-
E
E
-
I
R
--
P
E
---
I
----
D
---
Y
L
A
---
A
H
W
P
K
D
L
-------------------------------
P
A
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
--
D
---
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
A
W
C
F
--------------------
E
K
--------------
D
GA
Y
---------------
N
-----
V
T
K
G
--
K
A
L
L
E
G
Y
Q
S
--
V
R
------
P
L
S
E
A
E
L
E
--
A
L
P
L
L
S
R
G
S
A
L
R
F
F
L
T
R
L
Y
D
W
-----
L
T
----
T
P
A
-
G
A
L
V
VKKD
P
L
----
E
Y
L
R
K
L
R
F
H
R
T
I
A
N
V
A
E
Y
G
L
A
-----------------------
46
Fugue
69.07
17%
-14
* C4 *
-
4OCV
2
?
A:
[24-378]
----------------
T
N
E
A
L
F
D
V
A
S
H
F
A
L
E
G
--------------------
T
-
V
--
D
S
I
E
P
Y
G
D
G
H
I
N
T
T
Y
L
V
T
T
-
D
-------
G
-------
P
--
R
Y
I
L
Q
R
M
N
-
T
G
--
I
---
F
--
P
D
T
-
V
N
L
M
R
N
V
-
E
L
V
T
S
-
T
-
L
K
A
-
Q
G
K
E
T
L
D
I
V
R
T
T
S
G
D
T
W
A
E
I
D
G
G
A
W
R
V
Y
K
----
F
I
E
H
T
M
S
Y
N
L
V
P
-----------------------
N
-
P
D
V
--
F
R
E
A
G
R
A
F
G
D
F
Q
N
------
F
L
S
G
F
D
A
N
QL
T
-
E
--
T
-
I
--
A
H
F
----
H
D
T
P
H
R
F
E
D
F
--
K
K
A
L
A
A
-------
D
-
E
L
G
R
A
-
A
G
-
C
G
--
P
E
---
I
----
E
---
F
Y
L
---
S
-
H
A
D
Q
Y
A
V
---
V
M
D
-----
G
-----
L
---
R
---
D
G
S
I
P
L
R
V
T
H
N
D
T
K
L
N
N
I
L
M
D
A
TT
G
---
K
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
S
I
R
F
G
A
S
TALED---------------
E
R
--------------
D
--
L
---------------
D
K
V
H
F
S
T
E
L
F
--
R
A
Y
T
E
G
F
V
G
--
E
L
R
D----
S
I
T
A
R
E
A
E
--
L
L
P
F
S
G
N
L
L
T
M
E
C
G
M
R
F
L
A
D
Y
L
E
GDV
Y
F
----
A
T
K
Y
P
E
H
N
----
L
V
----
R
S
R
T
Q
I
K
L
V
R
E
M
E
Q
R
A
D
E
T
R
A
I
V
A
D
V
M
E
T
T--------------
33
Fugue
67.88
12%
-47
- C4 -
-
3I1A
2
?
A:
[3-330]
------------
K
Q
P
I
Q
A
Q
Q
L
I
E
L
L
K
V
H
Y
-------------------
G
I
--
D
-
I
--
H
T
A
Q
F
I
Q
G
G
A
D
T
N
A
F
A
Y
Q
A
D
S
-------
E
-------
S
K
-
S
Y
F
I
K
L
K
Y
-
G
Y
--
H
---
D
--
E
I
N
-
L
S
I
I
R
L
L
-
H
D
S
G
I
-
K
-
E
I
I
-
F
-
P
I
H
T
L
E
A
K
L
--------------
F
Q
Q
L
----
K
H
F
K
I
I
A
Y
P
F
I
H
A
-
P
-
N
G
F
T
Q
N
-----------
L
-
T
-
G
K
Q
--
W
K
Q
L
G
K
V
L
R
Q
I
H
E
------
T
S
V
P
I
S
I
Q
--
Q
-
Q
--
L
-
R
--
K
E
I
----
Y
S
P
K
W
R
E
I
V
R
--
S
F
Y
N
Q
I
EFDNSDD
K
-
L
T
A
A
F
-
K
S
-
F
F
--
N
Q
---
N
----
S
---
A
A
I
---
H
R
L
V
D
T
S
E
K
---
L
S
K
-----
K
-----
I
---
Q
---
P
D
L
D
K
Y
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
--
E
---
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
-
I
G
G
G
V
G
--------------------
N
V
--------------
W
--
N
---------------
K
-----
P
H
E
I
--
Q
Y
F
Y
E
G
Y
G
E
--
I
N
------
V
----
D
K
T
--
I
L
S
Y
Y
R
H
E
R
I
V
E
D
I
A
V
Y
G
Q
D
L
-----
L
S
----
R
N
Q
-
N
N
Q
S
----
R
L
----
E
S
F
K
Y
F
K
E
-----
M
F
D
P
N
N
V
V
E
I
A
F
A
T
E----------------
49
SP3
64.45
16%
6
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
M
D
L
D
T
D
A
N
-
T
I
P
E
L
-------
K
E
R
A
H
M
L
C
A
-
R
-
F
LGGAWK
T
V
--
P
-
L
EH
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
S
E
-------
V
YPPIRNE
P
N
-
K
V
L
L
R
V
Y
F
N
P
E
--
T
---
E
--
S
H
L
-
V
A
E
S
V
I
F
-
T
L
L
S
E
-
R
-
H
L
-----------------------
G
P
K
L
Y
G
I
F
----
S
G
--
G
R
L
E
E
Y
I
P
S
-
R
-
P
L
S
C
H
E
-----------
I
S
L
-
A
H
M
--
S
T
K
I
A
K
R
V
A
K
V
H
Q
--------
L
E
V
P
I
W
--
K
-
E
--
P
-
D
--
Y
L
C
----
E
A
L
Q
R
W
L
K
Q
L
--
T
G
T
V
D
A
-------
E
-
H
R
F
D
L
-
P
E
-
E
C
--
G
V
---
S
----
S
---
V
N
C
---
L
D
L
A
R
E
L
E
F
---
L
R
A
-----
H
-----
I
---
S
---
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
--
R
-----
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
I
--------------------
D
Y
--------------
D
--
I
DEAPF
Y
K
I
Q
TENFP-
E
-----
N
D
Q
M
--
L
E
F
F
L
N
Y
L
R
--
E
Q
GNTREN
E
L
Y
K
K
S
E
D
--
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
-----
L
Q
----
V
E
L
-
S
P
V
G
----
F
-----
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A
--------------------
61
HHSearch
62.44
14%
-48
- C4 -
-
2Q83
4
COTI_BACSU
A:
[21-305]
------------------------------
E
L
A
E
N
V
L
Q
-
G
-
W
------
D
V
--
Q
-
A
--
E
K
I
D
V
I
Q
----
A
L
V
W
K
V
H
T
D
----------------
S
G
-
A
V
C
L
K
R
I
H
-
R
P
------
E
--
K
K
A
-
L
F
S
I
F
A
Q
-
D
Y
L
A
K
-
K
-
G
M
N
-
V
-
P
G
I
L
P
N
K
-----------
K
G
-
S
L
Y
S
K
H
----
G
S
F
L
F
V
V
Y
D
W
I
E
G
-
R
-
P
F
E
L
-------------
T
-
V
-
K
Q
D
--
L
E
F
I
M
K
G
L
A
D
F
H
T
------
A
S
V
G
Y
Q
P
P
--
N
-
G
V
-
P
-
I
F
-
T
K
L
----
G
R
W
P
N
H
Y
T
K
R
--
C
K
Q
M
E
T
-------
W
K
L
M
A
E
A
-
E
K
-
E
D
--
P
F
---
S
Q
L
Y
L
Q
E
I
D
G
F
I
---
E
D
G
L
R
I
K
D
R
---
L
L
Q
-----
S
T
Y
V
P
W
T
---
E
---
Q
L
K
K
S
P
N
L
C
H
Q
D
Y
G
T
G
N
T
L
L
G
E
--
N
---
E
Q
I
W
V
I
D
L
D
T
V
S
F
D
L
P
I
R
D
L
R
K
M
I
I
P
L
L
D
--------------------
T
T
G-------------
V
--
W
---------------
D
-----
D
E
T
F
--
N
V
M
L
N
A
Y
E
S
--
R
A
------
P
L
T
E
E
Q
K
Q
--
V
M
F
I
D
M
L
F
--------------------------------------------------------------------------------------
39
Fugue
61.96
16%
5
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-------G
M
K
E
L
L
S
T
M
D
L
D
T
D
A
N
T
I
P
E
L
K
E
R
A
H
M
L
C
A
R
-
F
-
L
------
G
G
--
A
-
W
--
K
T
V
------
P
L
E
H
L
R
I
S
R
I
K
G
-------
G
-------
M
S
-
N
M
L
F
L
C
R
L
-
S
E
--
V
---
Y
--
P
P
I
-
R
N
E
P
N
K
V
-
L
L
R
V
Y
-
F
-
N
P
E
-
T
-
E
S
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
H
L
G
P
K
L
Y
G
I
F
----
S
G
G
--
R
L
E
E
Y
I
P
S
-
R
-
P
L
S
C
H
E
-----------
I
S
L
-
A
H
M
--
S
T
K
I
A
K
R
V
A
K
V
H
--------
Q
L
E
V
P
I
W
--
K
-
E
--
P
-
D
--
Y
L
C
----
E
A
L
Q
R
W
L
K
Q
L
--
T
G
T
V
D
A
-------
E
-
H
R
F
D
L
-
P
E
-
E
C
--
G
V
---
S
----
S
---
V
N
C
---
L
D
L
A
R
E
L
E
F
---
L
R
A
-----
H
-----
I
---
S
---
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
--
R
-----
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
I
--------------------
D
Y
--------------
D
--
I
DEAPF
Y
K
I
Q
TENFPE
N
-----
D
Q
M
L
--
E
F
F
L
N
Y
L
R
E
--
Q
G
------
N
T
R
E
N
E
L
Y
--
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
-----
G
V
W
G
L
L
Q
V
E
-
L
S
P
V
----
G
F
----
G
F
A
D
Y
-
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A
-------------------
58
HHSearch
59.22
22%
-10
- C4 -
-
6EF6
2
?
A:
[27-312]
----------------------------
D
V
T
I
A
Q
Q
A
L
T
-
H
-
Y
------
D
V
S-
D
-
N
--
A
S
L
R
L
L
-
N
L
S
E
N
A
T
Y
L
V
E
D
G
----------------
E
H
-
Q
S
I
L
R
V
H
R
-
Q
D
YH
Q
---
P
--
H
E
I
-
E
S
E
L
D
W
L
-
A
A
L
R
T
D
S
-
D
V
T
-
V
-
P
T
V
V
P
A
R
-----------
D
G
-
R
R
V
V
T
V
D
P
A
D
V
P
R
H
V
V
H
F
E
M
V
G
G
-
A
-
E
P
D
E
E
S
-----------
L
-
T
-
L
D
D
--
F
Q
T
L
G
R
I
T
A
S
L
H
E
------
H
S
Q
R
W
T
R
P
--
A
-
G
F
-
G
-
R
F
S
W
D
W
----
E
H
C
L
G
D
T
P
R
W
--
G
R
W
Q
D
A
-------------------
E
--
G
V
---
G
----
A
---
S
E
T
---
A
L
L
T
R
A
Q
D
L
---
L
H
R
-----
K
-----
L
---
E
E
Y
G
S
G
P
D
R
Y
G
L
I
H
A
D
L
R
L
A
N
L
L
V
D
S
--
S
TPQ
R
T
I
T
V
I
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
G
T
A
V
S
F
I
E
H
--------------------
D
---------------
P
--
R
---------------
L
-----
G
E
W
Q
--
E
S
W
V
A
G
Y
R
S
--
R
R
------
E
L
P
A
A
D
E
A
--
M
L
P
S
F
V
F
L
R
R
L
-----------------------------------------------------------------------------------
32
Fugue
57.50
19%
-4
- C4 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
--------
S
A
F
T
F
Q
T
L
H
P
D
T
I
M
D
A
L
F
E
H
G
I
R
V
D
S
G
L
T
P
-
L
-
N
------
S
Y
--
E
---------------
N
R
V
Y
Q
F
Q
D
E
D
-------
R
-------
R
--
R
F
V
V
K
F
Y
R
-
P
E
--
R
---
W
T
A
D
Q
I
-
L
E
E
H
Q
F
A
-
L
Q
L
V
N
-
D
-
E
V
P
-
V
-
A
A
P
V
A
F
N
G
Q
T
-------------
L
L
N
H
----
Q
G
F
Y
F
A
V
F
P
S
V
G
G
-
R
-
Q
F
--
E
A
-----------
D
-
N
-
I
D
Q
--
M
E
A
V
G
R
Y
L
G
R
M
H
Q
------
T
G
R
K
Q
L
F
I
--
H
-
R
--
P
-
T
--
I
G
L
----
N
E
Y
L
I
E
P
R
K
L
--
F
E
D
A
T
L
------------------
I
P
--
S
G
---
L
----
K
---
A
A
F
---
L
K
A
T
D
E
L
I
A
---
A
V
T
-----
A
-----
H
---
W
---
R
E
D
F
T
V
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
--
G
-----
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
L
L
N
G
D
-----------------------
K
--------------
A
--
E
---------------
Q
-----
R
M
Q
L
--
E
T
I
I
E
A
Y
E
E
--
F
S
------
E
F
D
T
A
E
I
G
L
I
E
P
L
R
A
M
R
L
V
Y
Y
L
A
W
L
M
R
R
W
A
D
-----
P
A
----
F
P
K
-
N
F
P
W
----
L
T
----
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
E
P
P
L
Q
L
TPMY--------------
44
Fugue
57.00
13%
-35
- C4 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
-----------------------
K
T
P
L
Y
E
T
L
N
E
S
S
A
V
A
-
L
-
A
------
V
K
--
L
-
G
--
L
T
L
T
C
Q
E
I
G
D
G
N
L
N
Y
V
F
H
I
Y
D
-------
R
----------
A
L
I
I
K
Q
A
V
-
P
Y
--
W
---
P
--
L
T
I
-
D
R
A
R
I
E
S
-
S
A
L
I
R
-
Q
-
G
E
H
-
V
-
P
H
L
V
------
P
R
V
F
Y
S
D
T
E
M
A
V
T
V
M
E
D
----
L
S
H
L
K
I
A
R
K
G
L
I
-------
E
G
E
-----------
N
-
Y
-
P
H
L
--
S
Q
H
I
G
E
F
L
G
K
T
L
F
Y
S
SDYA
L
E
P
K
V
K
K
Q
--
L
-
V
--
K
-
Q
--
F
T
N
----
P
E
L
C
D
I
T
E
R
L
VF
T
D
P
F
F
D
-------
H
-
D
T
N
D
F
-
E
E
-
E
L
--
R
P
---
F
----
V
---
E
K
L
W
N
N
D
S
V
K
I
E
A
A
K
---
L
K
K
-----
S
-----
F
---
L
---
T
--
S
A
E
T
L
I
H
G
D
L
H
T
G
S
I
F
A
S
E
--
H
---
E
-
T
K
V
I
D
P
E
F
A
F
Y
G
P
I
G
F
D
V
G
Q
F
I
A
N
L
F
L
N
A
L
S
R
DGADR
E
P
L
Y
E
H
V
N
Q
V
W
E
--------------
T
--
F
---------------
E
-----
E
T
F
S
--
E
A
W
Q
K
D
S
L
D
--
V
Y
------
A
N
I
D
G
Y
L
T
--
D
T
L
S
H
I
F
E
E
A
I
G
F
A
G
C
E
L
I
R
R
-----
T
I
----
G
L
A
-
H
V
A
D
----
L
D
----
T
I
V
P
F
D
K
R
I
G
R
K
R
L
A
L
E
T
G
T
A
F
I
E
K
R
SEFKT
I
T
D
V
I
E
L
F
K
L
L
V
K
59
HHSearch
56.93
19%
-32
- C4 -
-
1ZYL
-
SRKA_ECOLI
A:
[7-277]
-----------------------
T
F
Q
T
L
H
P
D
T
I
M
D
A
L
F
-
E
-
H
------
G
I
--
R
V
D
--
S
G
L
T
P
L
-
N
S
Y
E
N
R
V
Y
Q
F
Q
D
E
D
---------------
R
R
-
R
F
V
V
K
F
Y
R
-
P
E
RW
T
---
A
--
D
Q
I
-
L
E
E
H
Q
F
A
-
L
Q
L
V
N
-
D
-
E
V
P
-
V
-
A
A
P
V
A
F
N
------------
G
-
Q
T
L
L
N
H
----
Q
G
F
Y
F
A
V
F
P
S
V
G
G
-
R
-
Q
F
E
A
-------------
D
-
N
-
I
D
Q
--
M
E
A
V
G
R
Y
L
G
R
M
H
Q
------
T
G
R
K
Q
L
F
I
--
H
-
R
--
P
-
T
--
I
G
L
----
N
E
Y
L
I
E
P
R
K
L
--
F
E
D
A
T
L
----------------
I
-
P
S
--
G
L
---
K
----
A
---
A
F
L
---
K
A
T
D
E
L
I
A
A
---
V
T
A
-----
H
-----
W
-------
R
E
D
F
T
V
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
-------
G
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
L
L
N
G
D
K
A
---------------------------------------
E
---------------
Q
-----
R
M
Q
L
--
E
T
I
I
E
A
Y
E
E
--
F
S
------
E
F
D
T
A
E
I
G
--
L
I
E
P
L
R
A
M
R
L
V
Y
Y
---------------------------------------------------------------------------------
68
HHSearch
55.35
22%
-38
- C4 -
-
5UXD
2
?
A:
[4-255]
--------------------------
P
E
D
L
D
A
L
L
D
L
A
A
-
R
-
H
------
G
L
DL
D
-
G
--
G
T
L
R
T
E
E
I
G
L
D
F
R
V
A
F
A
R
A
H
D
---------------
G
G
-
D
W
V
L
R
L
P
R
-
R
P
D-
V
---
L
--
E
R
A
-
A
V
E
G
R
L
L
-
A
M
L
A
P
H
L
-
D
V
A
-
V
-
P
D
W
R
I
S
T
--------------------------
S
E
L
I
A
Y
P
L
L
P
G
-
S
-
P
G
L
T
V
A
ADG
E
V
S
W
HVDM
A
-
S
-
T
V
Y
--
A
R
S
L
G
S
V
V
A
Q
L
H
A
------
V
D
A
E
A
A
A
A
--
T
G
I
--
E
-
V
--
R
S
P
----
A
Q
V
R
G
A
W
R
Q
D
--
L
A
R
V
G
A
------------------
E
F
--
E
I
---
A
----
P
---
A
L
R
---
E
R
W
---
E
A
W
---
L
A
D
-----
D
-----
G
-------
C
W
P
G
H
S
V
L
T
H
G
E
L
Y
P
A
H
T
L
V
E
D
--
E
---
R
I
T
A
V
L
D
W
T
T
A
A
V
G
D
P
A
K
D
L
M
F
H
Q
V
S
A
---------------------------------------------------------
P
-----
S
A
I
F
--
E
V
A
L
Q
A
Y
A
E
--
G
G
------
G
R
P
-----------------------------------------------------------------------------------------------------
62
HHSearch
54.68
15%
-6
- C4 -
-
4OCV
2
?
A:
[24-320]
----------------------------
T
N
E
A
L
F
D
V
A
S
-
H
-
F
------
A
L
EG
T
-
V
--
D
S
I
E
P
Y
G
D
G
H
I
N
T
T
Y
L
V
T
T
D
----------------
G
P
-
R
Y
I
L
Q
R
M
N
-
T
G
--
I
FPD
T
--
V
N
L
M
R
N
V
E
L
V
T
-
S
T
L
K
A
-
Q
-
G
K
E
-
T
-
L
D
I
V
R
T
T
-----------
S
G
-
D
T
W
A
E
I
----
D
G
G
A
W
R
V
Y
K
F
I
E
H
-
T
-
M
S
Y
N
L
V
-----------
P
-
N
-
P
D
V
--
F
R
E
A
G
R
A
F
G
D
F
Q
N
------
F
L
S
G
F
D
A
N
--
Q
-
L
--
T
-
E
TI
A
H
F
----
H
D
T
P
H
R
F
E
D
F
--
K
K
A
L
A
A
-------
D
-
E
L
----
G
R
-
A
A
--
G
C
--------
G
---
P
E
I
---
E
F
Y
L
S
H
A
D
Q
---
Y
A
V
-----
V
-----
M
D
G
L
R
---
D
G
S
I
P
L
R
V
T
H
N
D
T
K
L
N
N
I
L
M
D
A
TT
G
---
K
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
S
I
R
F
G
A
S
--------------------
T
A
LEDERDLDK
V
----
H
--
F
---------------
S
-----
T
E
L
F
--
R
A
Y
T
E
G
F
V
G
E
L
R
D
------
S
I
T
A
R
E
A
E
--
L
L
P
F
S
G
N
L
L
T
------------------------------------------------------------------------------------
72
HHSearch
54.43
20%
-16
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[74-360]
----------------------------------------------------
E
-
H
--
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
S
E
VYPPIRN
E
-------
P
N
-
K
V
L
L
R
V
Y
F
-
N
P
E-
T
---
E
--
S
H
L
-
V
A
E
S
V
I
F
-
T
L
L
S
E
-
R
-
H
L
G
---
P
K
L
Y
G
I
F
-----------
S
---------------
G
G
R
L
E
E
Y
I
P
S
-
R
-
P
L
S
C
H
E
I
----------
S
-
L
-
A
H
M
--
S
T
K
I
A
K
R
V
A
K
V
H
Q
------
L
E
V
P
I
W
K
E
--
P
-
D
--
Y
L
C
--
E
A
L
----
Q
R
W
L
K
Q
L
T
G
T
--
V
D
A
E
H
R
----------
F
-
D
L
-
P
E
-
E
C
--
G
V
---
S
----
S
---
V
N
C
---
L
D
L
A
R
E
L
E
F
---
L
R
A
-----
H
-----
I
---
S
---
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
-------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
I
--------------------
D
Y
DIDEAPF
Y
K
I
Q
TEN
F
--
P
---------------
E
-----
N
D
Q
M
--
L
E
F
F
L
N
Y
L
R
--
E
Q
------
G
N
T
-----------------------------------------------------------------------------------------------------
73
HHSearch
54.02
20%
-15
- C4 -
-
1NW1
-
CKA2_CAEEL
B:
[74-360]
----------------------------------------------------
E
-
H
--
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
S
E
VYPPIRN
E
-------
P
N
-
K
V
L
L
R
V
Y
F
-
N
P
E-
T
---
E
--
S
H
L
-
V
A
E
S
V
I
F
-
T
L
L
S
E
-
R
-
H
L
G
---
P
K
L
Y
G
I
F
-----------
S
---------------
G
G
R
L
E
E
Y
I
P
S
-
R
-
P
L
S
C
H
E
I
----------
S
-
L
-
A
H
M
--
S
T
K
I
A
K
R
V
A
K
V
H
Q
------
L
E
V
P
I
W
K
E
--
P
-
D
--
Y
L
C
--
E
A
L
----
Q
R
W
L
K
Q
L
T
G
T
--
V
D
A
E
H
R
----------
F
-
D
L
-
P
E
-
E
C
--
G
V
---
S
----
S
---
V
N
C
---
L
D
L
A
R
E
L
E
F
---
L
R
A
-----
H
-----
I
---
S
---
L
S
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
-------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
I
--------------------
D
Y
DIDEAPF
Y
K
I
Q
TEN
F
--
P
---------------
E
-----
N
D
Q
M
--
L
E
F
F
L
N
Y
L
R
--
E
Q
------
G
N
T
-----------------------------------------------------------------------------------------------------
47
SP3
53.43
12%
-36
- C4 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
---------------
G
S
P
------------
A
A
W
V
E
R
L
F
-
G
-
Y
----------------
D
W
A
Q
Q
T
I
G
C
S
D
A
A
V
F
R
L
S
A
Q
-------
G
-------
R
P
-
V
L
F
V
K
T
D
L
-
S
G
--
A
---
L
--
N
E
L
-
Q
D
E
A
A
R
L
-
S
W
L
A
T
-
T
-
G
V
P
-
C
-
A
A
V
L
D
V
V
T
E
A
----------------------
G
R
D
W
L
L
L
G
E
V
P
G
-
Q
-
D
L
L
S
S
H
-----------
L
-
A
P
A
E
K
--
V
S
I
M
A
D
A
M
R
R
L
H
T
------
L
---------
D
-
P
--
A
-
T
--
C
P
F
----
D
H
Q
A
K
H
R
I
E
R
--
A
R
T
R
M
E
-------
A
-
G
L
V
D
Q
-
D
D
-
L
D
--
E
E
---
H
----
Q
---
G
L
------
A
P
A
E
L
F
A
---
R
L
K
-----
A
-----
R
---
M
---
P
D
G
E
D
L
V
V
T
H
G
D
A
C
L
P
N
I
M
V
E
N
--
G
---
R
F
S
G
F
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
T
R
D
I
A
----------------------
E
--------------
E
--
L
---------------
G
-----
G
E
W
A
--
D
R
F
L
V
L
Y
-
G
--
I
A
------
A
P
D
S
Q
R
I
A
--
F
Y
R
L
L
D
E
F
F
-------------------------------------------------------------------------------------
67
HHSearch
53.30
12%
-12
- C4 -
-
3I1A
4
?
B:
[5-272]
--------------------------
P
I
Q
A
Q
Q
L
I
E
L
L
K
V
H
-
Y
------
G
I
--
D
-
I
--
H
T
A
Q
F
I
Q
G
G
A
D
T
N
A
F
A
Y
Q
A
D
S
-------
E
-------
S
K
-
S
Y
F
I
K
L
K
Y
-
G
Y
--
H
--------
D
-
E
I
N
L
S
I
I
-
R
L
L
H
D
-
S
-
G
I
K
E
I
-
I
F
P
I
H
T
L
-----------
E
A
-
K
L
F
Q
Q
L
----
K
H
F
K
I
I
A
Y
P
F
I
H
A
-
P
-
N
G
F
T
Q
N
-----------
L
-
T
-
G
K
Q
--
W
K
Q
L
G
K
V
L
R
Q
I
H
E
------
T
S
V
P
I
S
I
Q
--
Q
-
Q
LR
K
-
E
--
I
Y
S
----
P
K
W
R
E
I
V
R
S
F
--
Y
N
Q
I
E
F
-------
D
-
N
S
D
D
K
L
T
A
A
F
K
--
S
F
---
F
----
N
---
Q
N
S
---
A
A
I
H
R
L
V
D
T
S
E
K
L
S
K
-----
K
-----
I
---
Q
---
P
D
L
D
K
Y
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
--
E
---
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
I
G
G
G
V
G
N
--------------------
V
---------------
W
--
N
---------------
K
-----
P
H
E
I
--
Q
Y
F
Y
E
G
Y
G
E
--
I
N
------
V
-------------------------------------------------------------------------------------------------------
60
HHSearch
53.21
17%
-8
- C4 -
-
4PDY
1
?
A:
[21-304]
-----------------------------
P
L
I
P
Q
A
V
V
S
-
K
-
Y
------
D
L
--
A
-
I
--
Q
Q
R
---
H
A
---
D
G
N
I
E
V
W
T
D
S
---------------
K
G
R
R
Y
A
A
K
R
S
S
-
I
---
A
---
P
--
A
H
C
-
R
I
M
V
Q
C
L
-
R
H
A
Q
E
-
Q
-
G
F
T
K
F
-
A
R
F
V
T
T
S
-----------
S
N
-
A
P
Y
V
R
H
----
G
D
F
T
Y
Y
V
T
E
W
V
S
G
-
Q
-
P
A
N
F
-------------
G
-
L
-
P
E
H
--
V
A
Q
T
A
Y
T
L
A
Q
F
H
E
------
A
T
R
S
F
R
T
D
--
W
-
K
----------DD
V
F
G
L
F
Q
A
R
W
R
D
L
--
R
Q
M
W
L
G
-------
A
-
D
R
K
R
E
-
K
D
-
A
F
D
Q
L
L
L
S
M
R
----
D
---
E
L
H
---
R
D
A
A
E
S
L
A
L
---
F
E
D
R
D
V
I
A
Y
-----
L
---
E
---
A
E
R
S
S
G
G
W
C
H
L
D
V
I
P
S
N
C
L
Y
T
P
--
Q
---
H
Q
V
V
L
I
D
F
E
L
A
R
P
A
P
R
A
L
D
M
A
H
L
L
R
R
S
L
E
--------------------
R
G
--------------
N
--
W
---------------
D
-----
G
H
L
A
--
Y
A
C
F
L
H
F
D
A
--
V
R
------
N
I
P
K
S
E
Y
R
--
A
V
E
A
I
L
R
F
P
Y
L
-----------------------------------------------------------------------------------
64
HHSearch
52.76
16%
-6
- C4 -
-
4WH3
8
NAHK_BIFL2
A:
[4-300]
----------------------------
S
N
E
V
L
F
G
I
A
S
-
H
-
F
------
A
L
EG
A
-
V
--
T
G
I
E
P
Y
G
D
G
H
I
N
T
T
Y
L
V
T
T
D
----------------
G
P
-
R
Y
I
L
Q
Q
M
N
-
T
S
--
I
FPD
T
V
-
N
L
M
-
R
N
V
E
L
V
T
-
S
T
L
K
A
-
Q
-
G
K
E
-
T
-
L
D
I
V
P
T
T
-----------
S
G
-
A
T
W
A
E
I
----
D
G
G
A
W
R
V
Y
K
F
I
E
H
-
T
-
V
S
Y
N
L
V
-----------
P
-
N
-
P
D
V
--
F
R
E
A
G
S
A
F
G
D
F
Q
N
------
F
L
S
E
F
D
A
S
--
Q
-
L
--
T
-
E
TI
A
H
F
----
H
D
T
P
H
R
F
E
D
F
--
K
A
A
L
A
A
-------
D
-
K
L
-----
G
-
R
A
--
A
A
---
C
----
Q
---
P
E
I
---
D
F
Y
L
S
H
A
D
Q
---
Y
A
V
-----
V
-----
M
D
G
L
R
---
D
G
S
I
P
L
R
V
T
H
N
D
T
K
L
N
N
I
L
M
D
A
TT
G
---
K
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
S
I
R
F
G
A
S
--------------------
T
A
LEDEKDLSK
V
----
H
--
F
---------------
S
-----
T
E
L
F
--
R
A
Y
T
E
G
F
V
G
E
L
R
G
------
S
I
T
A
R
E
A
E
--
L
L
P
F
S
G
N
L
L
T
------------------------------------------------------------------------------------
66
HHSearch
48.49
18%
-21
- C4 -
-
5IGI
3
?
A:
[2-258]
----------------------
T
V
V
T
T
A
D
T
S
Q
L
Y
A
L
A
A
-
R
-
H
------
G
L
K
-
L
-
H
--
G
P
L
T
V
N
E
L
G
L
D
Y
R
I
V
I
A
T
V
D
D
---------------
G
R
-
R
W
V
L
R
I
P
R
-
R
A
--
E
V
--
S
--
A
K
V
-
E
P
E
A
R
V
L
-
A
M
L
K
N
-
R
L
P
F
A
-
V
-
P
D
W
R
V
A
N
-----------
A
E
-
L
V
-
A
Y
P
----
M
L
E
D
S
T
A
-
V
I
Q
P
G
-
S
-
S
T
P
D
W
V
VPQ--------
D
-
S
-
E
V
F
--
A
E
S
F
A
T
A
L
A
A
L
H
A
------
V
P
I
S
A
A
V
D
--
A
G
M
--
L
-
I
--
R
T
P
----
T
Q
A
R
Q
K
V
A
D
D
--
V
D
R
V
R
R
----------------------
E
F
---
V
--------
V
N
D
---
K
R
L
H
R
W
Q
R
W
---
L
D
D
-----
D
-----
S
-------
S
W
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T-
E
---
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
L
M
V
F
---------------------------------------------------------
G
-----
E
E
G
L
--
A
K
L
L
L
T
Y
E
A
--
A
G
------
G
R
V
-----------------------------------------------------------------------------------------------------
71
HHSearch
37.45
15%
23
- C4 -
-
4R78
2
?
A:
[20-255]
---------------------------
H
M
E
K
I
I
K
E
K
I
S
-
S
L
L
------
S
Q
EE
E
-
V
--
L
S
V
E
Q
L
-
G
G
M
T
N
Q
N
Y
L
A
K
T
T
----------------
N
K
-
Q
Y
I
V
K
F
F
G
-
K
G
--
T
EK-
L
--
I
N
R
-
Q
D
E
K
Y
N
L
-
E
L
L
K
D
-
L
-
G
L
D
-
V
-
K
N
Y
L
F
D
I
-----------
E
--------------
A
G
I
K
V
N
E
Y
I
E
S
-
A
I
T
L
D
S
T
------------
S
-
I
-
K
T
K
--
F
D
K
I
A
P
I
L
Q
T
I
H
T
------
S
A
K
E
L
R
G
E
--
F
-
A
--
P
-
F
--
E
E
I
----
K
K
Y
E
S
L
I
E
E
Q
--
I
P
------------------------------------
Y
---
A
N
Y
---
E
S
V
R
N
A
V
F
S
---
L
E
K
-----
R
-----
L
---
A
---
D
L
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
S
P
--
Q
---
G
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
E
S
E
----------------------------------------
F
---------------
T
-----
S
Q
E
E
--
E
T
F
L
S
H
Y
E
S
--
D
Q
------
T
P
V
-----------------------------------------------------------------------------------------------------