@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AAR2_HUMAN: (2020-01-31 )
MAAVQMDPELAKRLFFEGATVVILNMPKGTEFGIDYNSWEVGPKFRGVKMIPPGIHFLHYSSVDKANPKEVGPRMGFFLSLHQRGLTVLRWSTLREEVDLSPAPESEVEAMRANLQELDQFLGPYPYATLKKWISLTNFISEATVEKLQPENRQICAFSDVLPVLSMKHTKDRVGQNLPRCGIECKSYQEGLARLPEMKPRAGTEIRFSELPTQMFPEGATPAEITKHSMDLSYALETVLNKQFPSSPQDVLGELQFAFVCFLLGNVYEAFEHWKRLLNLLCRSEAAMMKHHTLYINLISILYHQLGEIPADFFVDIVSQDNFLTSTLQVFFSSACSIAVDATLRKKAEKFQAHLTKKFRWDFAAEPEDCAPVVVELPEGIEMG
Atome Classification :
(20 SA)
-------------.....-------....10....--..-----.--.-20........30......--------..40...----..---------..----------------.50----------.-..----...--..60...-...---.-.70--....---.------.-.-..----80.--.......90....---....100.......110.......120-----....-.-----------.-.-------------130---------..-......----.------------140.-.--.....-----------.150-----......----------.160----.--....-------.-...-170-....--....180----------------....---.--..--190-------........----200......-----.210.......220..-.....230.....-----..------240......----.250......--.260..--------...-----...-270......--------.-------------280------..-----------..-..------...290...-....300-...--....-------..-----310---.--.......--.320.....----....-330....-------.---------------..340.---..--------....350-........360-----.......---..370.......-------.380..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------MAAVQ-------M
D
P
E
L
A
K
R
L
F
--FE-----G--
A
-
T
V
V
I
L
NMPKGTEF
G
I
DYN--------SWEVGPK----FR---------GV----------------KMI----------P-PG----
I
H
F
--
L
H
YSSVD-KA
N
---
P
-
K
E---VGPR---
M
------
G
-
F
-
F
L
----
S
L
H
--QRG
L
T
V
L
R
W
S
T
L
R
---
E
EVDLSPAP
E
S
E
V
E
A
M
R
A
N
L
Q
E
L
D
Q
F
L-----GPY
P
-
Y
-----------
A
-
T
-------------
L
-----------
K
K
-
W
I
S
L
T
N
----
F
------------
I
-
S
E
-
A
--
T
V
E
K
L-----------QPEN-----
R
Q
I
C
A
F
----------
S
D
------
V
--
L
P
V
L
-------S-M
K
H
-
T
K
--
D
R
VG--QNLPRCG----------------I
E
C
K
---
S
--
Y
Q
--
E
G
--------
L
A
RLPEMK----PRAG
T
E
I
R
F
-----
S
EL
P
T
Q
MFPEGA
T
P
A
E
-
I
T
K
H
SM
D
L
S
Y
A
L
E
-----
T
V
------
L
NKQFPS
S
P
----
Q
D
V
L
G
E
L
Q
F
A
--
F
V
-
C
F
L
--------
L
G
N
-----
V
Y
E
-
A
F
E
H
W
K
R
L
L
--------
N
-------------
L
--------
L
C
-----------
R
S
-
E
A
------
A
M
M
KH
H
T
L
Y
-
I
N
L
I
S
---
I
L
Y
--
H
Q
L
G-------EI-----
P
-----
A
--
D
F
F
V
D
I
V--SQ--DN
F
L
T
----
S
T
L
Q
-
V
F
F
SSAC-------
S
---------------
I
A
V
D
A
T
---
L
R
--------
K
K
A
E
K
F
--
Q
A
H
L
T
K
K
FR-------WDFAAEP---EDCA-
P
V
V
V
ELP-------EGIEMG
21
HHSearch
82.72
21%
-46
- C5 -
-
4ILG
-
AAR2_YEAST
A:
[1-337]
--------------------------------------------
M
--
N
-
T
V
P
F
T
S
A
P
I
E
V
T
I
G
I
D
Q
Y
--------
S
F
N
V
K
E
N
QP--
F
H
---------
G
I
----------------
K
D
I
----------
P
-
I
G
H---
V
H
V
--
I
H
F
Q
H
A
D
-
N
------------
S
S
M
R
---
Y
------
G
-
Y
-
W
F
----
D
C
R
--
M
G
N
-
F
Y
I
Q
Y
D
P
K
D
---
G
L
Y
K
M
M
E
E
R
D
G
A
K
F
E
N
I
V
H
N
F
K
E
R
Q
M
M
-----
V
S
Y
P
-
K
I----------
D
-
E
-------------
D
-----------
D
T
-
W
Y
N
L
T
E
----
F
------------
V
-
Q
M
-
D
--
K
I
R
K
I
-----------
V
R
K
D
-----
E
N
Q
F
S
Y
----------
V
D
------
S
-------------
S
-
M
-
T
-
T
V
--
Q
----------------------------------------------------
E
N
E
L
S
S
S
S
----
S
D
P
A
H
S
L
N
Y
-----
T
V
I
N
F
K
S
-
R
E
A
I
R
P
G
H
-
E
M
E
D
F
L
D
K
S
Y
Y
L
N
-----
T
V
------
M
L
Q
G
I
F
K
N
S
----
S
N
Y
F
G
E
L
Q
F
A
--
F
L
-
N
A
M
--------
F
F
G
-----
N
Y
G
-
S
S
L
Q
W
H
A
M
I
--------
E
-------------
L
--------
I
C
-----------
S
S
-
A
T
-------
V
--
P
K
H
M
L
-
D
K
L
D
E
---
I
L
Y
--
Y
Q
I
K
-------
T
L
-----
P
-----
E
--
Q
Y
-
S
D
I
L
--
L
N
--
E
R
V
W
N
----
I
C
L
Y
-
S
S
F
Q
K
N
S
-------------------------
L
H
N
T
---
E
K
--------
I
M
E
N
K
Y
--
P
E
L
L
------------------
D
---
D
E
H
N
-
P
T
I
V
G
G
L
-------------
22
HHSearch
79.89
20%
-44
- C5 -
-
3SBT
-
AAR2_YEAST
B:
[1-317]
--------------------------------------------
M
--
N
-
T
V
P
F
T
S
A
P
I
E
V
T
I
G
I
D
Q
Y
--------
S
F
N
V
K
E
N
QP--
F
H
---------
G
I
----------------
K
D
I
----------
P
-
I
G
H---
V
H
V
--
I
H
F
Q
H
A
D
-
N
------------
S
S
M
R
---
Y
------
G
-
Y
-
W
F
----
D
C
R
--
M
G
N
-
F
Y
I
Q
Y
D
P
K
D
---
G
L
Y
K
M
M
E
E
R
D
G
A
K
F
E
N
I
V
H
N
F
K
E
R
Q
M
M
-----
V
S
Y
P
-
K
-----------
I
D
E
-------------
D
-----------
D
T
-
W
Y
N
L
T
E
----
F
------------
V
-
Q
M
-
D
--
K
I
R
K
I
-----------
V
R
K
D
-----
E
N
Q
F
S
Y
----------
V
D
------
S
--
S
M
T
--------
T
-
V
Q
E
-
N
---
E
L
L
---------------------------------------------------------------
D
P
A
H
S
L
N
Y
-----
T
V
I
N
F
K
S
-
R
E
A
I
R
P
G
H
-
E
M
E
D
F
L
D
K
S
Y
Y
L
N
-----
T
V
------
M
L
Q
G
I
F
K
N
S
----
S
N
Y
F
G
E
L
Q
F
A
--
F
L
-
N
A
M
--------
F
F
G
-----
N
Y
G
-
S
S
L
Q
W
H
A
M
I
--------
E
-------------
L
--------
I
C
-----------
S
S
-
A
T
-------
V
--
P
K
H
M
L
-
D
K
L
D
E
---
I
L
Y
--
Y
Q
I
K
-------
T
L
-----
P
-----
E
--
Q
Y
-
S
D
I
L
--
L
N
--
E
R
V
W
N
----
I
C
L
Y
-
S
S
F
Q
K
N
S
-------------------------
L
H
N
T
---
E
K
--------
I
M
E
N
K
Y
--
P
E
L
L
-----------------------------------------------
31
Fugue
77.93
19%
-36
- C5 -
-
3SBT
-
AAR2_YEAST
B:
[1-317]
-------------
M
---------------------------------
N
-
T
V
P
F
T
S
A
P
I
E
V
T
I
G
I
D
Q
Y
--------
S
F
N
V
K
E
N
QP--
F
H
---------
G
I
----------------
K
D
I
----------
P
-
I
G
H---
V
H
V
--
I
H
F
Q
H
---------
A
-
D
N
---
S
S
M
R
---
Y
------
G
-
Y
-
W
F
----
D
C
R
--
M
-
G
N
F
Y
I
Q
Y
D
P
K
D
---
G
L
Y
K
M
M
E
E
R
D
G
A
K
F
E
N
I
V
H
N
F
K
E
R
Q
M
M
-----
V
S
Y
P
K
I
-----------
D
-
E
-------------
D
-----------
D
T
-
W
Y
N
L
T
E
----
F
------------
V
-
Q
M
-
D
--
K
I
R
K
I
-----------
V
R
K
D
-----
E
N
Q
F
S
Y
----------
V
D
----------------------------------------------------------------------
S
--
S
M
--------
T
T
V
Q
E
N
E
L
----
L
D
P
A
H
S
L
N
Y
-----
T
V
I
N
F
K
-
S
R
E
A
I
R
P
G
H
-
E
M
E
D
F
L
D
K
S
Y
Y
L
N
-----
T
V
------
M
L
Q
G
I
F
K
N
S
----
S
N
Y
F
G
E
L
Q
F
A
--
F
L
-
N
A
M
--------
F
F
G
-----
N
Y
G
-
S
S
L
Q
W
H
A
M
I
--------
E
-------------
L
--------
I
C
-----------
S
S
-
A
T
------
V
P
---
K
H
M
L
-
D
K
L
D
E
---
I
L
Y
--
Y
Q
I
K
-------
T
L
-----
P
-----
E
--
Q
Y
S
D
I
L
L
--
N
---
E
R
V
W
N
----
I
C
L
Y
-
S
S
F
Q
K
N
S
-------
L
---------------
H
N
T
E
K
I
---
M
E
--------
N
K
Y
P
E
L
--
L
--------------------------------------------------
5
PsiBlast_PDB
77.16
25%
7
- C5 -
-
4I43
-
AAR2_YEAST
A:
[3-286]
-------------------------------------------------
T
V
P
F
T
S
A
P
I
E
V
T
I
G
I
D
Q
Y
--------
S
F
N
V
K
E
N
QP--
F
H
---------
G
I
----------------
K
D
I
----------
P
-
I
G
H---
V
H
V
--
I
H
F
Q
H
A
D
-
N
S
S
---
M
-
R
Y
GYW
F
D
C
R
---
M
------
G
-
N
-
F
Y
----
I
Q
Y
DP
K
D
G
L
Y
-----
K
M
M
---
E
E
R
D
-----
G
A
K
F
E
N
I
------
R
-
Q
M
M
-----
V
S
Y
P
-
K
-----------
I
-
D
-------------
E
-----------
D
D
T
W
Y
N
L
T
E
----
F
------------
V
-
Q
M
-
D
--
K
I
R
K
I
VR---------
K
D
E
N
-----
Q
----
F
----------
S
Y
------
V
--
D
S
S
M
-------
T
-
T
V
Q
-
E
N
--
E
L
L
K
--
S
S
L
---------------------
E
A
K
---
N
--
E
D
--
D
P
--------
A
H
S
L
N
Y
----------
T
V
I
N
F
-----
K
S
------
R
E
A
I
R
P
G
H
-
E
M
E
D
F
L
D
K
S
Y
Y
L
N
-----
T
V
------
M
L
Q
G
I
F
K
N
S
----
S
N
Y
F
G
E
L
Q
F
A
--
F
L
-
N
A
M
--------
F
F
G
-----
N
Y
G
-
S
S
L
Q
W
H
A
M
I
--------
E
-------------
L
--------
I
C
------------
S
-
S
A
------
T
V
P
K
H
--
M
L
-
D
K
L
D
E
---
I
L
Y
--
Y
Q
I
K
-------
T
L
-----
P
-----
E
--
Q
Y
-------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.87
25%
7
- C5 -
-
3ZEF
-
AAR2_YEAST
A:
[3-291]
-------------------------------------------------
T
V
P
F
T
S
A
P
I
E
V
T
I
G
I
D
Q
Y
--------
S
F
N
V
K
E
N
QP--
F
H
---------
G
I
----------------
K
D
I
----------
P
-
I
G
H---
V
H
V
--
I
H
F
Q
H
A
D
-
N
S
S
---
M
-
R
Y
GYW
F
D
C
R
---
M
------
G
-
N
-
F
Y
----
I
Q
Y
DP
K
D
G
L
Y
-----
K
M
M
---
E
E
R
D
-----
G
A
K
F
E
N
I
V
H
N
F
K
E
R
-
Q
M
M
-----
V
S
Y
P
-
K
-----------
I
-
D
-------------
E
-----------
D
D
T
W
Y
N
L
T
E
----
F
------------
V
-
Q
M
-
D
--
K
I
R
K
I
VR---------
K
D
E
N
-----
Q
----
F
----------
S
Y
------
V
--
D
S
S
M
-------
T
-
T
V
Q
-
E
N
--
E
L
L
------------------------------------
E
D
--
D
P
--------
A
H
S
L
----------
N
Y
T
V
I
N
F
-----
K
S
------
R
E
A
I
R
P
G
H
-
E
M
E
D
F
L
D
K
S
Y
Y
L
N
-----
T
V
------
M
L
Q
G
I
F
K
N
S
----
S
N
Y
F
G
E
L
Q
F
A
--
F
L
-
N
A
M
--------
F
F
G
-----
N
Y
G
-
S
S
L
Q
W
H
A
M
I
--------
E
-------------
L
--------
I
C
------------
S
-
S
A
------
T
V
P
K
H
--
M
L
-
D
K
L
D
E
---
I
L
Y
--
Y
Q
I
K
-------
T
L
-----
P
-----
E
--
Q
Y
-------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
73.80
25%
-8
- C5 -
-
3SBT
-
AAR2_YEAST
B:
[3-279]
-------------------------------------------------
T
V
P
F
T
S
A
P
I
E
V
T
I
G
I
D
Q
Y
--------
S
F
N
V
K
E
N
QP--
F
H
---------
G
I
----------------
K
D
I
----------
P
-
I
G
H---
V
H
V
--
I
H
F
Q
H
A
D
-
N
S
S
---
M
-
R
Y
GYW
F
D
C
R
---
M
------
G
-
N
-
F
Y
----
I
Q
Y
DP
K
D
G
L
Y
-----
K
M
M
---
E
E
R
D
-----
G
A
K
F
E
N
I
V
H
N
F
K
E
R
-
Q
M
M
-----
V
S
Y
P
-
K
-----------
I
-
D
-------------
E
-----------
D
D
T
W
Y
N
L
T
E
----
F
------------
V
-
Q
M
-
D
--
K
I
R
K
I
VR---------
K
D
E
N
-----
Q
----
F
----------
S
Y
------
V
--
D
S
S
M
-------
T
-
T
V
Q
-
E
N
--
E
L
L
----------------------------------------
D
P
--------
A
H
S
L
----------
N
Y
T
V
I
N
F
-----
K
S
------
R
E
A
I
R
P
G
H
-
E
M
E
D
F
L
D
K
S
Y
Y
L
N
-----
T
V
------
M
L
Q
G
I
F
K
N
S
----
S
N
Y
F
G
E
L
Q
F
A
--
F
L
-
N
A
M
--------
F
F
G
-----
N
Y
G
-
S
S
L
Q
W
H
A
M
I
--------
E
-------------
L
--------
I
C
------------
S
-
S
A
------
T
V
P
K
H
--
M
L
-
D
K
L
D
E
---
I
L
Y
--
Y
Q
I
K
-------
T
L
-----
P
-----
E
--
Q
Y
-------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.27
23%
15
- C5 -
-
4ILG
-
AAR2_YEAST
A:
[3-287]
-------------------------------------------------
T
V
P
F
T
S
A
P
I
E
V
T
I
G
I
D
Q
Y
--------
S
F
N
V
K
E
N
QP--
F
H
---------
G
I
----------------
K
D
I
----------
P
-
I
G
H---
V
H
V
--
I
H
F
Q
H
A
D
-
N
S
S
---
M
-
R
Y
GYW
F
D
C
R
---
M
------
G
-
N
-
F
Y
----
I
Q
Y
DP
K
D
G
L
Y
-----
K
M
M
---
E
E
R
D
-----
G
A
K
F
E
N
I
V
H
N
F
K
E
R
-
Q
M
M
-----
V
S
Y
P
-
K
-----------
I
-
D
-------------
E
-----------
D
D
T
W
Y
N
L
T
E
----
F
------------
V
-
Q
M
-
D
--
K
I
R
K
I
-----------
V
R
K
D
-----
E
N
Q
F
S
Y
----------
V
D
------
S
-----------------------------------------------------
S
M
T
---
T
--
V
Q
--
E
N
--------
E
L
S
S
S
S
S
D
----
P
A
H
S
L
N
Y
T
V
-----
I
N
F
K
S
R
---
E
A
I
R
P
G
H
-
E
M
E
D
F
L
D
K
S
Y
Y
L
N
-----
T
V
------
M
L
Q
G
I
F
K
N
S
----
S
N
Y
F
G
E
L
Q
F
A
--
F
L
-
N
A
M
--------
F
F
G
-----
N
Y
G
-
S
S
L
Q
W
H
A
M
I
--------
E
-------------
L
--------
I
C
------------
S
-
S
A
------
T
V
P
K
H
--
M
L
-
D
K
L
D
E
---
I
L
Y
--
Y
Q
I
K
-------
T
L
-----
P
-----
E
--
Q
Y
-------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
69.72
18%
16
- C3 -
-
4GA6
1
AMPPA_THEKO
A:
[1-493]
MKAKIRILDMFSG
R
Y
T
V
L
-------
I
N
E
E
D
A
K
E
A
K
--
L
H
-----
P
--
D
-
D
L
V
K
I
E
A
G
K
K
A
V
Y
G
S
V
A
L
--------
S
N
L
V
G
K
G
----
E
V
---------
G
I
SRDVLDLHNFSEGETV
S
V
I
----------
P
-
A
G
----------
T
P
E
S
V
R
-
Y
I
K
---
K
-
K
M
---
H
G
E
K
---
L
RKVEIE
A
-
I
-
V
R
----
D
I
V
--
D
R
K
L
R
D
I
E
I
S
S
F
V
---
T
A
L
E
I
N
G
L
D
M
D
E
I
A
A
L
T
I
A
M
A
E
T
G
D
M
L
-----
D
I
D
R
-
K
-----------
P
-
I
-------------
M
DVHSIGGVPGN
K
T
-
N
I
L
V
V
P
----
I
------------
V
-
A
A
-
A
GL
T
I
P
K
T
-----------
S
S
R
A
I----
T
S
A
A
G
T
----------
A
D
------
V
--
V
E
V
F
-------
A
D
V
S
F
-
S
L
--
D
E
I
K
--
R
I
V
E
K
V
G
ACLVWGGALNLAPADD
I
T
I
K
---
A
--
E
R
--
A
L
SIDPTGLM
L
A
S
I
M
S
K
K
----
Y
A
M
G
S
Q
Y
V
L
-----
I
D
I
P
T
G
K
G
V
K
V
E
T
V
E
E
-
A
R
S
L
A
R
D
F
I
E
L
G
K
RLGQY
V
E
------
V
A
I
T
Y
G
G
Q
P
IGHT
V
G
P
A
L
E
A
R
E
A
--
L
S
-
A
L
M
--------
T
G
K
GPGSL
I
E
K
-
A
T
G
L
A
G
I
L
L
--------
E
-------------
M
GGVAPAGT
G
K
-----------
K
M
-
A
K
------
E
I
L
E
S
G
K
A
W
-
E
K
M
K
E
---
I
I
E
--
A
Q
G
G
DPNIKPE
E
I
-----
P
-----
I
GD
K
T
Y
T
F
T
A
--
A
T
--
S
G
Y
V
T
----
A
I
D
N
-
R
A
I
T
A
I
A
-------
R
AAGAPEDKGAGIELY
V
K
V
G
E
K
---
V
K
--------
E
G
D
P
L
F
--
T
I
H
A
E
H
E
A
R
-------
L
D
Q
A
I
V
L
---
A
R
R
T
E
P
I
R
I
E
---------------
40
Fugue
63.58
18%
32
- C6 -
-
5KDS
10
?
A:
[20-530]
------------H
M
A
S
V
L
ELEMRGD
S
I
S
E
A
K
K
R
K
V
WN
F
Q
-----
D
--
W
-
Q
I
T
G
L
S
A
R
A
G
D
K
I
T
V
Y
V
D
--------
V
A
E
G
D
P
T
PTLL
Y
K
QSLTQHGGA
T
S
----------------
F
Q
L
----------
K
-
P
G
----
K
N
E
--
I
T
I
P
E
I
N
-
Y
E
S
NGI
P
-
K
D
---
V
I
Q
G
---
G
------
D
-
L
-
F
F
TNYK
S
D
S
--
Q
K
R
A
P
K
V
R
I
E
G
A
S
---
K
Y
P
V
F
I
L
G
K
S
D
E
N
E
V
M
K
E
L
E
A
Y
V
E
K
I
K
AEPKT
T
P
N
I
-
F
-----------
A
-
V
SSNKSLEFVQATY
A
-----------
L
D
-
W
Y
K
K
N
N
----
K
------------
T
-
P
K
-
Y
--
T
A
E
Q
W
-----------
D
Q
Y
I
-----
A
D
A
M
G
F
WGFDNSKDVN
S
D
FNFR--
I
--
M
P
M
V
KNLSGGA
F
-
M
N
A
-
G
N
--
G
V
I
G
IR
P
G
N
Q
D
A
I
----------------
L
A
A
N
KGW
G
--
V
A
--
H
E
--------
L
G
H
N
F
D
T
G
----
G
R
T
I
V
E
V
T
N
-----
N
M
M
P
L
F
F
E
S
K
Y
K
T
K
T
R
-
I
T
D
Q
N
I
W
E
N
N
T
Y
P
-----
K
V
GLDDYS
N
N
E
L
Y
N
K
A
D
----
S
T
H
L
A
Q
L
A
P
L
--
W
Q
-
L
Y
L
--------
Y
D
N
T----
F
Y
G
-
K
F
E
R
Q
F
R
E
R
--------
D
FGNKNREDIYKSW
V
--------
V
A
-----------
A
S
-
D
A
MELDLT
E
F
F
A
R
H
G
I
R
-
V
D
--
D
---
K
V
K
--
E
D
L
A
-------
K
Y
-----
P
KPDKK
I
--
Y
Y
L
N
D
L
A
MN
Y
K
--
G
D
G
F
T
----
E
N
A
K
-
V
S
V
S
T
S
G
SNGNIKL
S
---------------
F
S
V
D
D
E
---
N
K
DNILGYEI
R
R
D
G
K
Y
--
V
G
F
T
S
N
D
S
F
-------
V
D
T
K
S
N
L
---
D
E
D
G
-
V
Y
V
V
T
P
Y
DRKLNTL
N
P
I
E
V
N
41
Fugue
59.47
21%
45
- C- -
-
4CP6
-
?
A:
[38-442]
----------TKV
G
S
I
I
Q
-------
Q
N
N
I
K
Y
K
V
L
T
--
V
E
-----
G
NI
G
-
T
V
Q
V
G
N
G
V
T
P
V
E
F
E
A
G
Q
D
GKPFTIPT
K
I
T
V
G
D
K
----
V
F
---------
T
V
----------------
T
E
V
ASQAFSYYPD
E
-
T
G
----
R
I
V
--
Y
Y
P
S
S
I
T
I
P
S
S
---
I
-
K
K
---
I
Q
K
K
----------
G
-
F
-
H
G
----
S
-
K
--
A
K
T
I
I
F
D
K
G
S
Q
L
----
E
K
I
E
D
R
A
F
D
F
S
E
L
E
--
E
I
E
L
P
A
S
L
E
Y
I
-----
G
T
S
A
-
F
-----------
S
-
F
-------------
S
-----------
Q
K
-
L
K
K
L
T
-----
F
------------
S
-
S
S
-
S
--
K
L
E
L
I
-----------
S
H
E
----------
A
F
----------
A
N
------
L
SN
L
E
K
L
-------
T
-
L
P
K
-
S
V
--
K
T
L
G
--
S
N
L
F
R
L
T
----------------
T
S
L
K
---
H
--
V
D
VE
E
G
--------
N
E
S
F
A
S
V
D
GVLF
S
K
D
K
T
Q
L
I
Y
-----
Y
--
P
S
Q
K
N
D
E
S
Y
K
T
P
K
-
E
T
K
E
L
A
S
Y
S
F
N
K
N
-----
S
Y
------
L
K
K
L
E
L
N
E
G
----
L
E
K
I
G
T
F
A
F
A
--
D
A
-
I
K
L
EEISLPNS
L
E
T
-----
I
E
R
L
A
F
Y
G
N
L
E
L
K
--------
E
-------------
L
--------
I
L
-----------
P
D
-
N
V
------
K
N
F
G
K
H
V
M
N
G
L
P
K
L
K
---
S
L
T
IG
N
N
I
N
-------
S
L
-----
P
-----
S
--
F
F
L
S
G
V
L
--
D
S
--
L
K
E
I
H
IKNK
S
T
E
F
-
S
V
K
K
D
T
F
-------
A
---------------
I
P
E
T
V
K
---
F
Y
--------
V
T
S
E
H
I
--
K
D
V
L
K
S
N
L
------------------
S
T
S
N
-
D
I
I
V
E
K
V
-------------
45
Fugue
59.23
18%
-22
- C2 -
-
4RAP
-
TIBC_ECOH1
A:
[10-391]
---------------------------
I
T
P
P
D
T
P
T
--
Q
A
-----
G
--
P
-
E
N
I
F
Y
D
F
N
D
G
A
R
V
L
L
P
E
G
--------
K
W
H
V
R
L
L
----
D
-----------------------------------------
A
-
D
S
----
E
N
I
--
L
F
C
C
D
V
D
-
K
G
W
---
V
-
T
S
---
S
K
K
Y
---
F
------
V
R
F
-
R
I
----
Q
V
F
--
R
Q
G
A
T
P
L
L
D
E
T
L
K
LKD
R
P
V
L
I
S
F
P
T
G
T
-----------
L
G
D
L
L
-----
G
W
F
P
-
Y
-----------
A
---------------------------
E
R
-
F
Q
S
L
H
K
CRLE
C
------------
T
M
S
Q
-
D
--
I
I
D
L
L
-----------
A
P
Q
Y
-----
P
Q
I
-
Q
F
----------
S
T
PDKPRT
V
--
A
P
Y
A
-------
T
-
Y
R
--
V
G
--
L
Y
F
G
--
G
D
T
N
N
Q
P
----------------
V
D
F
R
---
K
VG
F
H
--
R
S
--------
A
G
Y
I
L
G
V
D
----
P
R
E
A
P
-
V
R
L
-----
D
-
L
S
A
P
R
V
I
A
A
P
Y
V
C
I
-
A
T
Q
S
T
C
Q
A
K
Y
----------------
W
N
N
--
G
T
G
W
----
S
E
V
I
A
H
L
K
S
L
GY
R
V
M
C
I
D
--------
R
D
A
-----
H
Y
G
-
Q
G
F
V
W
N
H
I
P
WGAEDFTG
K
-------------
L
--------
P
L
-----------
Q
E
-
R
V
------
N
L
L
R
H
A
S
F
F
-
I
G
L
P
S
GL-
S
W
L
--
A
W
A
T
-------
R
I
-----
P
-----
V
--
V
L
I
S
G
F
S
--
L
P
--
N
S
E
F
Y
----
T
P
W
R
-
V
F
N
S
H
G
C
-------
Y
---------------
G
C
W
D
D
T
SLN
F
D
--------
H
H
D
F
L
W
--
C
P
R
H
K
N
T
D
R
-------
Q
F
E
C
T
R
L
ITG
A
Q
V
N
-
G
V
I
N
K
L
H
-------
R
S
L
T
--
36
Fugue
55.46
17%
-15
* C6 *
-
4CI2
1
CRBN_CHICK
B:
[71-451]
---------------
M
I
N
-------
F
D
T
S
L
P
T
S
H
M
--
Y
L
-----
G
--
S
-
D
M
E
E
F
H
G
R
T
L
H
D
D
D
-
S
C
Q
--------
V
I
P
V
L
P
H
----
V
M
---------------------------
V
M
L
----------
I
-
P
G
QTLP
L
Q
L
--
F
H
P
Q
E
V
S
-
M
V
R
---
N
-
L
I
---
Q
K
D
R
---
T
------
F
-
A
-
V
L
----
A
Y
S
--
N
V
R
E
R
E
A
H
F
G
T
T
A
---
E
I
Y
A
Y
R
E
E
Q
E
Y
G
I
E
T
V
K
V
K
A
I
G
R
Q
R
F
-------------------------
K
-------------
V
-----------
L
E
-
I
R
T
Q
S
D
----
G
------------
I
-
Q
Q
-
A
--
K
V
Q
I
L
------------
P
E
R
-----
V
L
P
S
T
M
----------
S
A
------
V
Q-
L
Q
S
L
-------
S
-
R
R
H
-
I
R
AF
R
Q
W
W
--
Q
K
Y
Q
K
R
K
----------------
F
H
C
A
---
S
--
L
T
--
S
W
--------
P
P
W
L
Y
S
L
Y
-----
D
A
E
T
L
M
E
R
-----
V
K
R
Q
L
H
E
W
D
E
N
L
K
D
E
S
-
L
P
T
N
P
I
D
F
S
Y
R
V
A
-----
A
C
------
L
-------
P
----
I
D
D
A
L
R
I
Q
L
L
--
K
I
-
G
S
A
--------
I
Q
R
-----
L
R
C
-
E
L
D
I
M
N
K
C
T
--------
S
-------------
L
--------
C
C
-----------
K
-----------
Q
C
Q
D
T
E
I
T
-
T
K
N
E
I
---
F
S
L
--
S
L
C
G
--------------
P
-----
M
--
A
A
Y
V
N
-----
P
--
H
G
Y
I
H
----
E
T
L
T
-
V
Y
--
K
A
C
-------
N
---------------
L
N
L
S
G
R
---
P
S
--------
T
E
H
S
W
F
PG
Y
A
W
T
I
A
Q
C
R
ICGNHMG
W
K
F
T
A
T
K
---
K
D
M
S
-
P
Q
K
F
W
G
L
-------
T
R
S
A
L
L
6
PsiBlast_PDB
51.08
23%
-
- C5 -
-
4ILI
-
AAR2_YEAST
A:
[3-279]
-------------------------------------------------
T
V
P
F
T
S
A
P
I
E
V
T
I
G
I
D
Q
Y
--------
S
F
N
V
K
E
N
QP--
F
H
---------
G
I
----------------
K
D
I
----------
P
-
I
G
H---
V
H
V
--
I
H
F
Q
H
A
D
-
N
S
S
---
M
-
R
Y
GYW
F
D
C
R
---
M
------
G
-
N
-
F
Y
----
I
Q
Y
DP
K
D
G
L
Y
-----
K
M
M
---
E
E
R
D
-----
G
A
K
F
E
N
I
V
H
N
F
K
E
R
-
Q
M
M
-----
V
S
Y
P
-
K
-----------
I
-
D
-------------
E
-----------
D
D
T
W
Y
N
L
T
E
----
F
------------
V
-
Q
M
-
D
--
K
I
R
K
I
-----------
V
R
K
D
-----
E
N
Q
F
S
Y
----------
V
D
------
S
-----------------------------------------------------
S
M
T
---
T
--
V
Q
--
E
N
--------
E
L
S
S
S
S
S
D
----
P
A
H
S
L
N
Y
T
V
-----
I
N
F
K
S
------------------
D
K
S
Y
Y
L
N
-----
T
V
------
M
L
Q
G
I
F
K
N
S
----
S
N
Y
F
G
E
L
Q
F
A
--
F
L
-
N
A
M
--------
F
F
G
-----
N
Y
G
-
S
S
L
Q
W
H
A
M
I
--------
E
-------------
L
--------
I
C
------------
S
-
E
A
------
T
V
P
K
H
--
M
L
-
D
K
L
D
E
---
I
L
Y
--
Y
Q
I
K
-------
T
L
-----
P
-----
E
--
Q
Y
-------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
50.91
11%
22
- C4 -
-
3GYC
5
?
A:
[13-393]
----------EIS
P
R
A
I
T
M------
W
D
F
S
W
L
E
R
R
W
--
P
G
-----
A
--
G
Y
E
D
W
D
Q
V
L
D
E
L
S
E
R
G
--
Y
N
--------
A
I
R
I
D
A
Y
----
P
H
---------
L
I
----------------
A
E
N
----------
P
M
K
K
----
W
L
L
KE
V
W
N
Q
Q
D
W
-
G
S
P
---
D
M
N
E
---
V
Q
V
Q
PNL
N
------
L
-
F
-
L
S
----
K
C
K
--
E
R
D
I
K
V
G
L
S
S
W
Y
R
---
L
D
V
D
E
V
C
L
K
L
D
T
P
E
K
L
A
D
C
W
L
T
I
L
R
S
I
-----
E
E
D
G
-
L
-----------
L
-
D
-------------
T
-----------
I
L
-
Y
V
D
L
C
N
----
E
------------
W
-
P
G
-
D
--
S
W
A
P
F
-----------
F
A
K
T
-----
Y
P
N
V
G
W
----------
G
N
------
W
--
Y
K
E
E
-------
S
-
L
R
W
M
K
T
--
S
L
E
K
M-
R
Q
V
Y
P
-
D
M---------------
P
F
L
Y
---
S
--
F
D
--
H
G
--------
D
V
K
----------------
K
Y
-----
E
E
V
D
C
S
F
L
D
L
Y
E
H
H
I
W
M
A
Q
Q
N
G
G
E
F
Y
K
L
V
G
-----
Y
G
------
Y
N
R
F
L
P
D
D
Y
----
K
N
V
V
K
N
A
E
R
V
--
Y
R
----------------------
E
-
R
P
G
Y
W
Q
K
L
L
--------
T
-------------
D
--------
K
I
-----------
E
L
M
A
S
------
V
A
R
K
N
R
R
P
L
-
V
T
T
E
C
WGL
V
D
Y
--
K
D
W
P
-------
L
L
-----
K
-----
W
--
D
W
V
K
D
L
C
--
E
L
--
G
T
I
T
A
----
A
R
T
G
M
W
V
G
V
A
T
S
-------
N
---------------
F
C
G
P
Q
F
---
A
G
M-------
W
R
D
V
E
W
--
H
K
R
L
T
S
I
I
R
SSPLD--
E
S
L
T
K
N
N
---
E
V
A
A
-
K
L
L
K
R
L
--------------
4
PsiBlast_PDB
48.11
25%
-
- C- -
-
3SBS
-
AAR2_YEAST
A:
[3-279]
-------------------------------------------------
T
V
P
F
T
S
A
P
I
E
V
T
I
G
I
D
Q
Y
--------
S
F
N
V
K
E
N
QP--
F
H
---------
G
I
----------------
K
D
I
----------
P
-
I
G
H---
V
H
V
--
I
H
F
Q
H
A
D
-
N
S
S
---
M
-
R
Y
GYW
F
D
C
R
---
M
------
G
-
N
-
F
Y
----
I
Q
Y
DP
K
D
G
L
Y
-----
K
M
M
---
E
E
R
D
-----
G
A
K
F
E
N
I
V
H
N
F
K
E
R
-
Q
M
M
-----
V
S
Y
P
-
K
-----------
I
-
D
-------------
E
-----------
D
D
T
W
Y
N
L
T
E
----
F
------------
V
-
Q
M
-
D
--
K
I
R
K
I
VR---------
K
D
E
N
-----
Q
----
F
----------
S
Y
------
V
--
D
S
S
M
-------
T
-
T
V
Q
-
E
N
--
E
L
L
K
-------------------------------------------------
A
H
S
L
----------
N
Y
T
V
I
N
F
-----
K
S
------
R
E
A
I
R
P
G
H
-
E
M
E
D
F
L
D
K
S
Y
Y
L
N
-----
T
V
------
M
L
Q
G
I
F
K
N
S
----
S
N
Y
F
G
E
L
Q
F
A
--
F
L
-
N
A
M
--------
F
F
G
-----
N
Y
G
-
S
S
L
Q
W
H
A
M
I
--------
E
-------------
L
--------
I
C
------------
S
-
S
A
------
T
V
P
K
H
--
M
L
-
D
K
L
D
E
---
I
L
Y
--
Y
Q
I
K
-------
T
L
-----
P
-----
E
--
Q
Y
-------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
47.78
25%
-
- C- -
-
4ILH
-
AAR2_YEAST
B:
[3-279]
-------------------------------------------------
T
V
P
F
T
S
A
P
I
E
V
T
I
G
I
D
Q
Y
--------
S
F
N
V
K
E
N
QP--
F
H
---------
G
I
----------------
K
D
I
----------
P
-
I
G
H---
V
H
V
--
I
H
F
Q
H
A
D
-
N
S
S
---
M
-
R
Y
GYW
F
D
C
R
---
M
------
G
-
N
-
F
Y
----
I
Q
Y
DP
K
D
G
L
Y
-----
K
M
M
---
E
E
R
D
-----
G
A
K
F
E
N
I
V
H
N
F
K
E
R
-
Q
M
M
-----
V
S
Y
P
-
K
-----------
I
-
D
-------------
E
-----------
D
D
T
W
Y
N
L
T
E
----
F
------------
V
-
Q
M
-
D
--
K
I
R
K
I
VR---------
K
D
E
N
-----
Q
----
F
----------
S
Y
------
V
--
D
S
S
M
-------
T
-
T
V
Q
-
E
N
--
E
-----------------------------------------------------
H
S
L
----------
N
Y
T
V
I
N
F
-----
K
S
------
R
E
A
I
R
P
G
H
-
E
M
E
D
F
L
D
K
S
Y
Y
L
N
-----
T
V
------
M
L
Q
G
I
F
K
N
S
----
S
N
Y
F
G
E
L
Q
F
A
--
F
L
-
N
A
M
--------
F
F
G
-----
N
Y
G
-
S
S
L
Q
W
H
A
M
I
--------
E
-------------
L
--------
I
C
------------
S
-
S
A
------
T
V
P
K
H
--
M
L
-
D
K
L
D
E
---
I
L
Y
--
Y
Q
I
K
-------
T
L
-----
P
-----
E
--
Q
Y
-------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
47.56
12%
5
- C1 -
-
4L3A
-
?
A:
[48-516]
-------------
D
N
V
N
I
-------
P
D
S
T
F
K
A
Y
L
N
--
G
L
LGQAS
T
--
A
-
N
I
T
E
A
Q
M
D
S
L
T
Y
I
T
L
A
N
I
--------
N
V
---
T
D
----
L
T
---------
G
I
----------------
E
Y
A
----------
H
-
N
-----
I
K
D
--
L
T
I
N
N
I
H
-
A
T
N
---
Y
-
N
Q
---
I
S
G
L
---
S
------
N
-
L
E
R
L
----
R
I
M
--
G
A
D
V
T
S
D
K
I
P
N
L
S
---
G
L
T
N
L
T
L
L
D
L
S
H
S
A
H
D
D
S
I
L
T
K
I
N
T
L
P
-----
K
V
T
S
-
I
DLSYNGAITDI
M
-
P
-------------
L
-----------
K
T
-
M
P
E
L
K
S
----
L
NIQFDGVHDYRG
I
-
E
D
F
P
--
K
L
N
T
L
-----------
L
A
Y
S
-----
Q
T
I
G
G
K
----------
K
L
INSDI-
K
--
S
S
K
L
-------
T
-
Y
N
A
-
E
N
--
Q
T
L
Y
--
V
P
F
S
L
M
T
----------------
E
R
T
V
---
N
--
Y
D
--
G
Y
--------
V
P
D
F
V
K
S
T
----
A
S
S
D
T
Y
F
T
M
NEQQV
N
G
N
R
L
T
I
T
S
D
G
L
T
V
S
D
-
V
S
K
T
D
F
D
N
L
E
K
M
E
-----
Y
N
------
A
R
I
D
L
S
Y
Q
S
----
Y
N
T
P
E
Q
F
Q
N
G
--
G
S
-
Y
T
I
--------
S
M
P
-----
I
Y
D
-
H
Y
F
T
V
D
H
S
L
--------
N
-------------
I
--------
T
A
DSEKTYIENQL
V
T
-
E
A
------
T
F
L
S
D
I
H
A
K
-
T
D
D
G
S
---
T
V
T
--
S
D
F
A
-------
D
K
VDFNT
P
-----
G
--
T
Y
T
V
T
L
Q
--
S
E
NN
A
G
L
K
A
----
T
P
V
Q
-
V
N
V
T
I
K
A
-------
K
---------------
T
T
I
T
A
D
---
E
K
--------
I
T
Y
K
V
D
--
T
S
K
T
E
A
A
F
L
-------
A
D
I
K
A
T
T
---
N
D
G
T
-
A
I
T
S
D
F
A
-------
T
V
V
D
L
S
8
PsiBlast_PDB
36.49
29%
0
- C- -
-
3SZE
-
ESPP_ECO57
A:
[902-1000]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
S
N
S
A
Y
A
M
R
T
N
L
S
E
S
D
K
-
L
-----
E
V
K
K
-
H
-----------
L
-
S
-------------
G
-----------
E
N
-
N
I
L
L
V
D
----
F
------------
L
-
Q
K
-
P
--
T
P
E
K
Q
LNIELVSAPKD
T
N
E
N
VFKAS
K
Q
T
I
G
F
----------
S
D
------
V
--
T
P
V
I
-------
T
-
T
R
E
-
T
D
--
D
K
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
30.26
25%
-112
- C5 -
-
2WJ8
-
NCAP_HRSVA
A:
[210-291]
-----------------------------------------------------------------
Y
E
--------
V
F
E
K
H
P
H
----
F
------------------------------
I
----------
D
-
V
F
----
V
H
F
--
G
I
A
Q
S
S
T
-
R
G
G
---
S
-
R
V
---
E
G
I
F
---
A
------
G
-
L
-
F
M
----
N
A
Y
--
G
A
G
Q
V
M
L
R
W
G
V
L
A
---
K
S
V
K
N
I
M
L
G
H
A
S
V
Q
A
------
E
M
E
Q
V
V
-----
E
V
Y
E
-
Y
-----------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
29.82
27%
-75
- C5 -
-
4XDP
2
KDM4C_HUMAN
A:
[181-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
T
E
D
-
M
D
L
Y
S
---
I
N
Y
--
L
H
F
G
-------
E
------
P
-----
K
--
S
W
Y
A
I
P
P
--
E
H
--
G
K
R
L
E
----
R
L
A
Q
-
G
F
F
P
S
S
--------
S
---------------
Q
G
C
D
A
F
---
L
R
--------
H
K
M
T
L
I
--
S
P
S
V
L
K
K
Y
G
-------
I
P
F
D
K
I
T
---
Q
E
A
G
-
E
F
M
I
T
F
P
-------
Y
G
Y
H
A
G