@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AFG2H_HUMAN: (2020-01-31 )
MSSKKNRKRLNQSAENGSSLPSAASSCAEARAPSAGSDFAATSGTLTVTNLLEKVDDKIPKTFQNSLIHLGLNTMKSANICIGRPVLLTSLNGKQEVYTAWPMAGFPGGKVGLSEMAQKNVGVRPGDAIQVQPLVGAVLQAEEMDVALSDKDMEINEEELTGCILRKLDGKIVLPGNFLYCTFYGRPYKLQVLRVKGADGMILGGPQSDSDTDAQRMAFEQSSMETSSLELSLQLSQLDLEDTQIPTSRSTPYKPIDDRITNKASDVLLDVTQSPGDGSGLMLEEVTGLKCNFESAREGNEQLTEEERLLKFSIGAKCNTDTFYFISSTTRVNFTEIDKNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPNLPDVKVAGLVKITLKDFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCREAALLALEEDIQANLIMKRHFTQALSTVTPRIPESLRRFYEDYQEKSGLHTL
Atome Classification :
(22 SA)
.........10....-....20........30........40........50........60........70........80........90........100.--.-.....110.......120.......130.......140.......150.-..-....160.....-..170.......180....----...190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330......-----------.340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460....--...470.......480.......490.......500.......510.......520.......530.......540.----.....----.550.......560.......570......---.580---.......590--....---....600.......610......-.620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730....-...740-........750.......760.......770.......780.......790.......800.......810.......820.......830.......840.....-----------------------..850----------------------.----....-----...860.......870.......880.......890.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSS
K
K
N
R
K
R
L
NQSAE-NGSSL
P
S
A
A
S
S
C
A
EARAPSAGSDFAATSG
T
L
T
V
T
N
L
L
E
K
V
D
D
KI
P
K
T
F
Q
N
S
L
I
H
LGLNTMKSANICIGR
P
V
L
L
TSLNGK
Q
E
V
Y
T
AWPM--A-GFPGGKV
G
L
S
E
M
A
Q
KNVGVRPGD
A
I
Q
V
Q
P
L
V
G
A
V
L
Q
AEEM
D
V
ALSDKDM-EI-
N
E
E
E
L
T
G
C
I
L
R
K-LDG
K
I
V
LPG
N
F
L
Y
C
T
FYGR----
P
Y
K
L
Q
V
L
R
VKGAD
G
M
I
LGGPQSDSD
T
D
A
Q
R
M
A
F
E
QSSMETS
S
L
E
L
S
L
Q
L
SQLDLEDTQIPTSRSTPYKP
I
D
D
R
ITNKAS
D
V
L
L
D
VTQSPGDGS
G
L
M
L
E
EVTG
L
K
C
N
F
E
SAREG
N
E
Q
L
T
E
E
E
R
L
L
K
F
S
IG
A
K
CNT
D
T
F
Y
F
ISST
T
R
V
N
F
T
EID-----------KNSKEQDN
Q
F
K
V
T
Y
D
M
I
G
G
L
S
S
Q
L
K
A
I
R
E
I
I
ELPLKQ
P
E
L
F
K
SYGIPAP
R
G
V
L
L
YGPPGT
G
K
T
M
I
A
R
A
V
A
N
EV
G
A
Y
V
SVIN
G
P
E
I
I
S
K
F
YG
E
T
E
A
K
L
R
Q
I
F
A
E
A
TLRHP
S
I
I
F
I
D
E
L
D
A
LCPKREG
A
Q
--
N
E
V
E
K
R
V
V
A
S
L
L
T
L
M
D
GIGSEVSEG
Q
V
L
V
L
GATNRP
H
A
L
D
A
A
L
RRPGRFD
K
E
I
E
IGVPN
A
Q
D
R
L
D
I
L
Q
K
L
L
R
R
V
P
H
L
----
L
T
E
A
E
----
L
L
Q
L
A
NSAHGYVG
A
D
L
K
V
L
C
NEA
G
L
C
A
L
R
R
---
I
L
K
K---QPNLPD
V
K
V
---
A
G
L
V
---
K
I
T
L
K
D
F
L
Q
A
M
N
DI
R
P
S
A
M
R
E
I
A
-IDVPNVSWSDIGG
L
E
S
I
K
L
K
L
E
Q
AVEWPLKH
P
E
S
F
I
RMGIQPPK
G
V
L
L
YGPPGC
S
K
T
M
I
A
K
A
L
ANESG
L
N
F
L
A
IK
G
P
E
L
M
N
K
YVG
E
S
E
R
A
V
R
E
T
F
R
K
A
R
AVA
P
S
I
I
F
FDE
L
D
A
L
A
V
ER-GSSL-G-A
G
N
V
A
D
R
V
L
A
Q
L
L
T
E
MD
G
I
E
Q
LK
D
V
T
I
L
A
ATNR
P
D
R
I
D
K
A
L
MRPGRI
D
R
I
I
Y
V
PLPD
A
A
T
R
R
E
I
F
K
L
Q
F
HSMPVSNEV
D
L
D
E
L
I
L
QTDAYS
G
A
E
I
V
A
V
C
R
E
A
A
L
L
A
-----------------------
L
E
E
D
-----------------------
I
----
Q
A
N
L
-----
I
M
K
R
H
F
T
Q
A
L
S
T
VTPRI
P
E
S
L
R
R
F
Y
E
D
Y
Q
E
KSGLHTL
34
HHSearch
85.19
51%
0
- C- -
-
5C1A
-
TERA_HUMAN
K:
[201-745]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
--
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
---
Q
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
-----
D
D
V
D
----
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
---
K
M
D
L
---
I
D
L
E
D
E
T
I
D
---
A
E
V
M
NSL
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
R
E
T
V
-
V
E
V
P
Q
V
T
W
E
D
I
G
G
L
E
D
V
K
R
E
L
Q
E
L
V
Q
Y
P
V
E
H
P
D
K
F
L
K
F
G
M
T
P
S
K
G
V
L
F
Y
G
P
P
G
C
G
K
T
L
L
A
K
A
I
A
N
E
C
Q
A
N
F
I
S
I
K
G
P
E
L
L
T
M
W
F
G
E
S
E
A
N
V
R
E
I
F
D
K
A
R
Q
A
A
P
C
V
L
F
F
D
E
L
D
S
I
A
K
A
R
--------
G
G
G
A
A
D
R
V
I
N
Q
I
L
T
E
M
D
G
M
S
T
K
K
N
V
F
I
I
G
A
T
N
R
P
D
I
I
D
P
A
I
L
R
P
G
R
L
D
Q
L
I
Y
I
P
L
P
D
E
K
S
R
V
A
I
L
K
A
N
L
R
K
S
P
V
A
K
D
V
D
L
E
F
L
A
K
M
T
N
G
F
S
G
A
D
L
T
E
I
C
Q
R
A
C
K
L
A
-----------------------
I
R
E
S
IESEIRRERERQTNPSAMEVEED
D
----
P
V
P
E
-----
I
R
R
D
H
F
E
E
A
M
R
F
A
R
R
S
---------------------
6
PsiBlast_PDB
79.03
48%
-44
- C2 -
-
5C1B
2
TERA_HUMAN
A:
[189-739]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
--
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
R
---
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
-
K
L
----
A
D
D
V
D
----
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
KMD
L
I
D
L
---
E
D
E
T
I
D
A
E
V
---
M
N
S
L
---
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
R
E
T
V
-
V
E
V
P
Q
V
T
W
E
D
I
G
G
L
E
D
V
K
R
E
L
Q
E
L
V
Q
Y
P
V
E
H
P
D
K
F
L
K
F
G
M
T
P
S
K
G
V
L
F
Y
G
P
P
G
C
G
K
T
L
L
A
K
A
I
A
N
E
C
Q
A
N
F
I
S
I
K
G
P
E
L
L
T
M
W
F
G
E
S
E
A
N
V
R
E
I
F
D
K
A
R
Q
A
A
P
C
V
L
F
F
D
E
L
D
S
I
A
K
A
R
--------
G
G
G
A
A
D
R
V
I
N
Q
I
L
T
E
M
D
G
M
S
T
K
K
N
V
F
I
I
G
A
T
N
R
P
D
I
I
D
P
A
I
L
R
P
G
R
L
D
Q
L
I
Y
I
P
L
P
D
E
K
S
R
V
A
I
L
K
A
N
L
R
K
S
P
V
A
K
D
V
D
L
E
F
L
A
K
M
T
N
G
F
S
G
A
D
L
T
E
I
C
Q
R
A
C
K
L
A
-----------------------
I
R
E
S
-----------------------
I
----
E
S
E
I
RPE--
I
R
R
D
H
F
E
E
A
M
R
F
A
R
R
S
V
S
D
N
D
I
R
K
Y
E
M
F
A
Q
-------
5
PsiBlast_PDB
78.88
48%
-41
- C2 -
-
5C18
2
TERA_HUMAN
A:
[189-739]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
--
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
R
---
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
-
K
L
----
A
D
D
V
D
----
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
KMD
L
I
D
L
---
E
D
E
T
I
D
A
E
V
---
M
N
S
L
---
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
R
E
T
V
-
V
E
V
P
Q
V
T
W
E
D
I
G
G
L
E
D
V
K
R
E
L
Q
E
L
V
Q
Y
P
V
E
H
P
D
K
F
L
K
F
G
M
T
P
S
K
G
V
L
F
Y
G
P
P
G
C
G
K
T
L
L
A
K
A
I
A
N
E
C
Q
A
N
F
I
S
I
K
G
P
E
L
L
T
M
W
F
G
E
S
E
A
N
V
R
E
I
F
D
K
A
R
Q
A
A
P
C
V
L
F
F
D
E
L
D
S
I
A
K
A
R
---------
G
G
A
A
D
R
V
I
N
Q
I
L
T
E
M
D
G
M
S
T
K
K
N
V
F
I
I
G
A
T
N
R
P
D
I
I
D
P
A
I
L
R
P
G
R
L
D
Q
L
I
Y
I
P
L
P
D
E
K
S
R
V
A
I
L
K
A
N
L
R
K
S
P
V
A
K
D
V
D
L
E
F
L
A
K
M
T
N
G
F
S
G
A
D
L
T
E
I
C
Q
R
A
C
K
L
A
-----------------------
I
R
E
S
-----------------------
I
----
E
S
E
I
RPE--
I
R
R
D
H
F
E
E
A
M
R
F
A
R
R
S
V
S
D
N
D
I
R
K
Y
E
M
F
A
Q
-------
14
PsiBlast_PDB
78.38
47%
-47
- C2 -
-
5FTL
3
TERA_HUMAN
A:
[190-760]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
--
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
R
---
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
-
K
L
----
A
D
D
V
D
----
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
KMD
L
I
D
L
---
E
D
E
T
I
D
A
E
V
---
M
N
S
L
---
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
R
E
T
V
-
V
E
V
P
Q
V
T
W
E
D
I
G
G
L
E
D
V
K
R
E
L
Q
E
L
V
Q
Y
P
V
E
H
P
D
K
F
L
K
F
G
M
T
P
S
K
G
V
L
F
Y
G
P
P
G
C
G
K
T
L
L
A
K
A
I
A
N
E
C
Q
A
N
F
I
S
I
K
G
P
E
L
L
T
M
W
F
G
E
S
E
A
N
V
R
E
I
F
D
K
A
R
Q
A
A
P
C
V
L
F
F
D
E
L
D
S
I
A
K
A
R
G
G
N
I
G
-
D
-
G
G
G
A
A
D
R
V
I
N
Q
I
L
T
E
M
D
G
M
S
T
K
K
N
V
F
I
I
G
A
T
N
R
P
D
I
I
D
P
A
I
L
R
P
G
R
L
D
Q
L
I
Y
I
P
L
P
D
E
K
S
R
V
A
I
L
K
A
N
L
R
K
S
P
V
A
K
D
V
D
L
E
F
L
A
K
M
T
N
G
F
S
G
A
D
L
T
E
I
C
Q
R
A
C
K
L
A
IRESIESEI-----------------------------------------------
V
P
E
-----
I
R
R
D
H
F
E
E
A
M
R
F
A
R
R
S
V
S
D
N
D
I
R
K
Y
E
M
F
A
Q
-------
16
PsiBlast_PDB
77.68
47%
-48
- C2 -
-
5FTN
4
TERA_HUMAN
A:
[190-760]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
--
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
R
---
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
-
K
L
----
A
D
D
V
D
----
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
KMD
L
I
D
L
---
E
D
E
T
I
D
A
E
V
---
M
N
S
L
---
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
R
E
T
V
-
V
E
V
P
Q
V
T
W
E
D
I
G
G
L
E
D
V
K
R
E
L
Q
E
L
V
Q
Y
P
V
E
H
P
D
K
F
L
K
F
G
M
T
P
S
K
G
V
L
F
Y
G
P
P
G
C
G
K
T
L
L
A
K
A
I
A
N
E
C
Q
A
N
F
I
S
I
K
G
P
E
L
L
T
M
W
F
G
E
S
E
A
N
V
R
E
I
F
D
K
A
R
Q
A
A
P
C
V
L
F
F
D
E
L
D
S
I
A
K
A
R
G
G
N
I
G
-
D
-
G
G
G
A
A
D
R
V
I
N
Q
I
L
T
E
M
D
G
M
S
T
K
K
N
V
F
I
I
G
A
T
N
R
P
D
I
I
D
P
A
I
L
R
P
G
R
L
D
Q
L
I
Y
I
P
L
P
D
E
K
S
R
V
A
I
L
K
A
N
L
R
K
S
P
V
A
K
D
V
D
L
E
F
L
A
K
M
T
N
G
F
S
G
A
D
L
T
E
I
C
Q
R
A
C
K
L
A
IRESIESEI-----------------------------------------------
V
P
E
-----
I
R
R
D
H
F
E
E
A
M
R
F
A
R
R
S
V
S
D
N
D
I
R
K
Y
E
M
F
A
Q
-------
13
PsiBlast_PDB
77.15
47%
-48
- C2 -
-
5FTK
3
TERA_HUMAN
A:
[190-760]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
--
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
R
---
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
-
K
L
----
A
D
D
V
D
----
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
KMD
L
I
D
L
---
E
D
E
T
I
D
A
E
V
---
M
N
S
L
---
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
R
E
T
V
-
V
E
V
P
Q
V
T
W
E
D
I
G
G
L
E
D
V
K
R
E
L
Q
E
L
V
Q
Y
P
V
E
H
P
D
K
F
L
K
F
G
M
T
P
S
K
G
V
L
F
Y
G
P
P
G
C
G
K
T
L
L
A
K
A
I
A
N
E
C
Q
A
N
F
I
S
I
K
G
P
E
L
L
T
M
W
F
G
E
S
E
A
N
V
R
E
I
F
D
K
A
R
Q
A
A
P
C
V
L
F
F
D
E
L
D
S
I
A
K
A
R
G
G
N
I
G
-
D
-
G
G
G
A
A
D
R
V
I
N
Q
I
L
T
E
M
D
G
M
S
T
K
K
N
V
F
I
I
G
A
T
N
R
P
D
I
I
D
P
A
I
L
R
P
G
R
L
D
Q
L
I
Y
I
P
L
P
D
E
K
S
R
V
A
I
L
K
A
N
L
R
K
S
P
V
A
K
D
V
D
L
E
F
L
A
K
M
T
N
G
F
S
G
A
D
L
T
E
I
C
Q
R
A
C
K
L
A
IRESIESEI-----------------------------------------------
V
P
E
-----
I
R
R
D
H
F
E
E
A
M
R
F
A
R
R
S
V
S
D
N
D
I
R
K
Y
E
M
F
A
Q
-------
15
PsiBlast_PDB
77.09
47%
-51
- C2 -
-
5FTM
4
TERA_HUMAN
A:
[190-760]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
--
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
R
---
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
-
K
L
----
A
D
D
V
D
----
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
KMD
L
I
D
L
---
E
D
E
T
I
D
A
E
V
---
M
N
S
L
---
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
R
E
T
V
-
V
E
V
P
Q
V
T
W
E
D
I
G
G
L
E
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V
K
R
E
L
Q
E
L
V
Q
Y
P
V
E
H
P
D
K
F
L
K
F
G
M
T
P
S
K
G
V
L
F
Y
G
P
P
G
C
G
K
T
L
L
A
K
A
I
A
N
E
C
Q
A
N
F
I
S
I
K
G
P
E
L
L
T
M
W
F
G
E
S
E
A
N
V
R
E
I
F
D
K
A
R
Q
A
A
P
C
V
L
F
F
D
E
L
D
S
I
A
K
A
R
G
G
N
I
G
-
D
-
G
G
G
A
A
D
R
V
I
N
Q
I
L
T
E
M
D
G
M
S
T
K
K
N
V
F
I
I
G
A
T
N
R
P
D
I
I
D
P
A
I
L
R
P
G
R
L
D
Q
L
I
Y
I
P
L
P
D
E
K
S
R
V
A
I
L
K
A
N
L
R
K
S
P
V
A
K
D
V
D
L
E
F
L
A
K
M
T
N
G
F
S
G
A
D
L
T
E
I
C
Q
R
A
C
K
L
A
IRESIESEI-----------------------------------------------
V
P
E
-----
I
R
R
D
H
F
E
E
A
M
R
F
A
R
R
S
V
S
D
N
D
I
R
K
Y
E
M
F
A
Q
-------
19
PsiBlast_PDB
76.70
47%
-109
- C2 -
-
6MCK
1
?
A:
[2-552]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
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A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
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K
R
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K
T
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--
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
R
---
A
H
V
I
V
M
A
A
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R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
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D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
-
K
L
----
A
D
D
V
D
----
L
E
Q
V
A
N
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T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
-------------------------------
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
R
E
T
V
-
V
E
V
P
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V
T
W
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D
I
G
G
L
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K
R
E
L
Q
E
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Y
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M
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G
P
P
G
C
G
K
T
L
L
A
K
A
I
A
N
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C
Q
A
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F
I
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I
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G
P
E
L
L
T
M
W
F
G
E
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E
A
N
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R
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I
F
D
K
A
R
Q
A
A
P
C
V
L
F
F
D
E
L
D
S
I
A
K
A
R
-----------
A
A
D
R
V
I
N
Q
I
L
T
E
M
D
G
M
S
T
K
K
N
V
F
I
I
G
A
T
N
R
P
D
I
I
D
P
A
I
L
R
P
G
R
L
D
Q
L
I
Y
I
P
L
P
D
E
K
S
R
V
A
I
L
K
A
N
L
R
K
S
P
V
A
K
D
V
D
L
E
F
L
A
K
M
T
N
G
F
S
G
A
D
L
T
E
I
C
Q
R
A
C
K
L
A
IRESIESEIRRERERQT-----------------------------------------
E
-----
I
R
R
D
H
F
E
E
A
M
R
F
A
R
R
S
V
S
D
N
D
I
R
K
Y
E
M
F
A
Q
-------
23
HHSearch
76.57
42%
32
- C2 -
-
5G4F
-
VAT_THEAC
C:
[2-723]
---------------------------------------
E
S
N
N
G
I
I
L
R
V
A
E
-------
A
N
S
T
D
P
G
M
S
R
V
R
L
D
E
S
S
R
R
L
L
D
A
E
I
G
D
V
V
E
I
E
K
V
R
--
K
T
V
G
R
V
Y
R
A
RP
E
-
D
E
N
K
G
I
V
R
I
D
S
V
M
R
N
N
C
G
A
S
I
G
D
K
V
K
V
R
K
V
R
--
T
E
I
A
K
K
V
T
L
A
P
I
I
R
K
D
Q
R
L
K
F
G
E
G
I
E
E
Y
V
Q
R
A
-
L
I
R
R
P
M
L
E
Q
D
N
I
S
V
P
G
L
T
L
AGQT
G
L
L
F
K
V
V
K
T
L
P
S
K
V
P
V
-------------------------------
E
I
G
----------------------------------------
E
---------------------------------------------------
E
T
K
I
E
I
R
E
E
P
-----------
A
S
-
E
V
L
E
E
V
S
R
I
S
Y
E
D
I
G
G
L
S
E
Q
L
G
K
I
R
E
M
I
E
L
P
L
K
H
P
E
L
F
E
R
L
G
I
T
P
P
K
G
V
I
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
S
G
A
N
F
L
S
I
N
G
P
E
I
M
S
K
Y
Y
G
Q
S
E
Q
K
L
R
E
I
F
S
K
A
E
E
T
A
P
S
I
I
F
I
D
E
I
D
S
I
A
P
K
R
E
E
V
Q
--
G
E
V
E
R
R
V
V
A
Q
L
L
T
L
M
D
G
M
K
E
---
R
G
H
V
I
V
I
G
A
T
N
R
I
D
A
I
D
P
A
L
R
R
P
G
R
F
D
R
E
I
E
I
G
V
P
D
R
N
G
R
K
E
I
L
M
I
H
T
R
N
M
P
L
G
MSEE
E
K
N
K
F
----
L
E
E
M
A
D
Y
T
Y
G
F
V
G
A
D
L
A
A
L
V
R
E
S
A
M
N
A
L
R
R
---
Y
L
P
E
---
I
D
L
D
-
K
P
I
P
---
T
E
I
L
EKM
V
V
T
E
D
D
F
K
N
A
L
K
S
I
E
P
S
S
L
R
E
V
M
-
V
E
V
P
N
V
H
W
D
D
I
G
G
L
E
D
V
K
R
E
I
K
E
T
V
E
L
P
L
L
K
P
D
V
F
K
R
L
G
I
R
P
S
K
G
F
L
L
Y
G
P
P
G
V
G
K
T
L
L
A
K
A
V
A
T
E
S
N
A
N
F
I
S
I
K
G
P
E
V
L
S
K
W
V
G
E
S
E
K
A
I
R
E
I
F
K
K
A
K
Q
V
A
P
A
I
V
F
L
D
E
I
D
S
I
A
P
R
R
-
G
T
T
S
-
D
--
S
G
V
T
E
R
I
V
N
Q
L
L
T
S
L
D
G
I
E
V
M
N
G
V
V
V
I
G
A
T
N
R
P
D
I
M
D
P
A
L
L
R
A
G
R
F
D
K
L
I
Y
I
P
P
P
D
K
E
A
R
L
S
I
L
K
V
H
T
K
N
M
P
L
A
P
D
V
D
L
N
D
I
A
Q
R
T
E
G
Y
V
G
A
D
L
E
N
L
C
R
E
A
G
M
N
A
-----------------------
Y
R
E
N
-----------------------
P
----
D
A
T
S
-----
V
S
Q
K
N
F
L
D
A
L
K
T
I
R
P
S
V
D
E
E
V
I
K
F
Y
R
T
L
---------
9
PsiBlast_PDB
76.37
47%
-46
- C2 -
-
3CF1
4
TERA_MOUSE
A:
[190-760]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
--
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
R
---
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
-
K
L
----
A
D
D
V
D
----
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
KMD
L
I
D
L
---
E
-
E
T
I
D
A
E
V
---
M
N
S
L
---
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
R
E
T
V
-
V
E
V
P
Q
V
T
W
E
D
I
G
G
L
E
D
V
K
R
E
L
Q
E
L
V
Q
Y
P
V
E
H
P
D
K
F
L
K
F
G
M
T
P
S
K
G
V
L
F
Y
G
P
P
G
C
G
K
T
L
L
A
K
A
I
A
N
E
C
Q
A
N
F
I
S
I
K
G
P
E
L
L
T
M
W
F
G
E
S
E
A
N
V
R
E
I
F
D
K
A
R
Q
A
A
P
C
V
L
F
F
D
E
L
D
S
I
A
K
A
R
----
G
-
D
-
G
G
G
A
A
D
R
V
I
N
Q
I
L
T
E
M
D
G
M
S
T
K
K
N
V
F
I
I
G
A
T
N
R
P
D
I
I
D
P
A
I
L
R
P
G
R
L
D
Q
L
I
Y
I
P
L
P
D
E
K
S
R
V
A
I
L
K
A
N
L
R
K
S
P
V
A
K
D
V
D
L
E
F
L
A
K
M
T
N
G
F
S
G
A
D
L
T
E
I
C
Q
R
A
C
K
L
A
IRESIESEI-----------------------------------------------
V
P
E
-----
I
R
R
D
H
F
E
E
A
M
R
F
A
R
R
S
V
S
D
N
D
I
R
K
Y
E
M
F
A
Q
-------
8
PsiBlast_PDB
76.32
47%
-46
- C2 -
-
5C19
-
TERA_HUMAN
A:
[189-759]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
--
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
R
---
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
-
K
L
----
A
D
D
V
D
----
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
KMD
L
I
D
L
---
E
D
E
T
I
D
A
E
V
---
M
N
S
L
---
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
R
E
T
V
-
V
E
V
P
Q
V
T
W
E
D
I
G
G
L
E
D
V
K
R
E
L
Q
E
L
V
Q
Y
P
V
E
H
P
D
K
F
L
K
F
G
M
T
P
S
K
G
V
L
F
Y
G
P
P
G
C
G
K
T
L
L
A
K
A
I
A
N
E
C
Q
A
N
F
I
S
I
K
G
P
E
L
L
T
M
W
F
G
E
S
E
A
N
V
R
E
I
F
D
K
A
R
Q
A
A
P
C
V
L
F
F
D
E
L
D
S
I
A
K
A
R
G
G
N
I
G
-
D
-
G
G
G
A
A
D
R
V
I
N
Q
I
L
T
E
M
D
G
M
S
T
K
K
N
V
F
I
I
G
A
T
N
R
P
D
I
I
D
P
A
I
L
R
P
G
R
L
D
Q
L
I
Y
I
P
L
P
D
E
K
S
R
V
A
I
L
K
A
N
L
R
K
S
P
V
A
K
D
V
D
L
E
F
L
A
K
M
T
N
G
F
S
G
A
D
L
T
E
I
C
Q
R
A
C
K
L
A
IRESIESEI-----------------------------------------------
V
P
E
-----
I
R
R
D
H
F
E
E
A
M
R
F
A
R
R
S
V
S
D
D
D
I
D
K
Y
E
D
F
A
D
-------
11
PsiBlast_PDB
76.10
47%
-42
- C2 -
-
3CF3
3
TERA_MOUSE
A:
[190-760]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
--
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
R
---
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
-
K
L
----
A
D
D
V
D
----
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
KMD
L
I
D
L
---
E
D
E
T
I
D
A
E
V
---
M
N
S
L
---
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
R
E
T
V
-
V
E
V
P
Q
V
T
W
E
D
I
G
G
L
E
D
V
K
R
E
L
Q
E
L
V
Q
Y
P
V
E
H
P
D
K
F
L
K
F
G
M
T
P
S
K
G
V
L
F
Y
G
P
P
G
C
G
K
T
L
L
A
K
A
I
A
N
E
C
Q
A
N
F
I
S
I
K
G
P
E
L
L
T
M
W
F
G
E
S
E
A
N
V
R
E
I
F
D
K
A
R
Q
A
A
P
C
V
L
F
F
D
E
L
D
S
I
A
K
A
R
G
G
N
I
G
-
D
-
G
G
G
A
A
D
R
V
I
N
Q
I
L
T
E
M
D
G
M
S
T
K
K
N
V
F
I
I
G
A
T
N
R
P
D
I
I
D
P
A
I
L
R
P
G
R
L
D
Q
L
I
Y
I
P
L
P
D
E
K
S
R
V
A
I
L
K
A
N
L
R
K
S
P
V
A
K
D
V
D
L
E
F
L
A
K
M
T
N
G
F
S
G
A
D
L
T
E
I
C
Q
R
A
C
K
L
A
IRESIESEI-----------------------------------------------
V
P
E
-----
I
R
R
D
H
F
E
E
A
M
R
F
A
R
R
S
V
S
D
N
D
I
R
K
Y
E
M
F
A
Q
-------
12
PsiBlast_PDB
75.80
47%
-50
- C2 -
-
5FTJ
4
TERA_HUMAN
A:
[190-760]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
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G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
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L
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A
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A
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K
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E
K
T
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--
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
R
---
A
H
V
I
V
M
A
A
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R
P
N
S
I
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A
L
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R
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G
R
F
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D
I
G
I
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D
A
T
G
R
L
E
I
L
Q
I
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M
-
K
L
----
A
D
D
V
D
----
L
E
Q
V
A
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H
G
H
V
G
A
D
L
A
A
L
C
S
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A
A
L
Q
A
I
R
K
KMD
L
I
D
L
---
E
D
E
T
I
D
A
E
V
---
M
N
S
L
---
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
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-
V
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V
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L
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A
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L
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A
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G
G
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G
-
D
-
G
G
G
A
A
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L
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M
D
G
M
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K
N
V
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I
I
G
A
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I
I
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P
A
I
L
R
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G
R
L
D
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L
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Y
I
P
L
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D
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R
V
A
I
L
K
A
N
L
R
K
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V
A
K
D
V
D
L
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F
L
A
K
M
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N
G
F
S
G
A
D
L
T
E
I
C
Q
R
A
C
K
L
A
IRESIESEI-----------------------------------------------
V
P
E
-----
I
R
R
D
H
F
E
E
A
M
R
F
A
R
R
S
V
S
D
N
D
I
R
K
Y
E
M
F
A
Q
-------
22
HHSearch
75.53
32%
15
- C2 -
-
5E7P
5
?
A:
[17-744]
---------------------------------------
T
P
L
S
H
L
R
L
T
A
R
L
N
------
T
S
A
L
D
S
R
R
G
V
V
R
L
H
P
E
V
L
A
A
L
G
I
R
E
W
D
A
V
A
L
T
G
T
R
--
T
T
A
A
V
A
G
V
A
--
G
P
G
V
P
A
G
T
A
L
L
D
D
V
T
L
S
N
A
G
V
R
E
N
A
A
V
L
V
S
P
V
T
--
V
Y
G
A
R
S
V
T
V
S
G
S
R
L
A
T
-
Q
----
S
I
S
P
A
T
L
R
M
A
-
L
L
G
K
V
M
T
V
G
D
T
V
S
L
L
P
R
D
--------------------
S
A
A
T
---------------
S
A
L
A
S
S
V
G
I
T
W
T
S
E
L
L
T
V
T
A
V
D
P
-------------------------------
P
----------------------------------------------
G
T
V
S
V
Q
P
N
S
V
V
S
W
G
T
G
T
PEDPAPPPTGR
H
T
V
S
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V
S
F
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D
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V
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L
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L
L
K
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L
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A
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H
L
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L
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G
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A
G
V
G
K
A
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M
V
R
A
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C
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--
R
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V
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L
D
G
P
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V
G
A
L
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R
L
R
S
V
T
S
A
V
A
-
A
V
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S
G
G
V
L
F
I
A
D
V
D
A
L
L
P
A
G
N
E
M
R
----
P
P
E
P
V
A
T
L
I
L
A
E
L
R
K
A
V
A
---
T
P
G
V
A
F
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A
V
P
E
N
V
D
A
R
L
R
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C
D
R
E
L
G
L
S
L
P
D
A
T
A
R
R
S
L
L
E
M
L
L
R
G
V
P
S
------
E
D
L
D
----
L
G
D
I
A
D
H
T
P
G
F
V
V
A
D
L
A
A
V
V
R
E
G
A
L
R
A
A
A
R
---
A
S
S
S
---
D
------------
D
D
P
---
V
L
R
H
A
D
L
E
G
A
L
T
V
I
R
P
L
S
R
S
A
-
E
-
V
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V
G
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D
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G
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M
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K
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A
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L
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L
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L
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D
K
W
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L
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A
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A
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D
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A
P
S
L
V
F
L
D
E
I
D
A
L
A
P
R
R
-
G
Q
N
F
---
D
S
G
V
T
D
K
V
V
A
S
L
L
T
E
L
D
G
I
E
P
L
R
D
V
V
V
L
G
A
T
N
R
P
D
L
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D
P
A
L
L
R
P
G
R
L
E
R
L
V
F
V
E
P
P
D
A
A
A
R
R
D
I
L
R
T
A
G
K
S
I
P
L
A
D
D
V
D
L
D
S
L
A
D
D
L
D
G
Y
S
A
A
D
C
V
A
L
L
R
E
S
A
M
T
A
-----------------------
M
R
R
S
-----------------------
I
----
D
A
A
D
-----
V
T
A
A
D
V
A
K
A
R
E
T
V
R
P
S
L
D
P
A
Q
V
E
S
L
R
E
F
A
E
K
------
7
PsiBlast_PDB
75.26
47%
-38
- C2 -
-
6CHS
4
?
H:
[217-779]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
R
E
M
V
E
L
P
L
R
H
P
Q
L
F
K
S
I
G
I
K
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P
R
G
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L
L
Y
G
P
P
G
T
G
K
T
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M
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
M
A
G
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S
E
S
N
L
R
K
A
F
E
E
A
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K
N
S
P
A
I
I
F
I
D
E
I
D
S
I
A
P
K
R
E
K
T
N
--
G
E
V
E
R
R
V
V
S
Q
L
L
T
L
M
D
G
M
K
---
A
R
S
N
V
V
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
P
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
-
K
L
----
A
D
D
V
D
----
L
E
Q
I
A
A
E
T
H
G
Y
V
G
S
D
L
A
A
L
C
S
E
A
A
M
Q
Q
I
R
E
KMD
L
I
D
L
---
D
E
D
T
I
D
A
E
V
---
L
D
S
L
---
G
V
T
M
D
N
F
R
Y
A
L
G
V
S
N
P
S
A
L
R
E
V
A
V
V
E
V
P
N
V
R
W
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G
G
L
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K
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L
K
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V
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P
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H
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K
F
L
K
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G
L
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P
S
R
G
V
L
F
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G
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P
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M
L
A
K
A
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A
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A
A
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L
L
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M
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F
G
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S
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N
I
R
D
I
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D
K
A
R
A
A
A
P
C
V
V
F
L
D
E
L
D
S
I
A
K
A
R
-
G
G
S
I
-
G
D
A
G
G
A
S
D
R
V
V
N
Q
L
L
T
E
M
D
G
M
T
S
K
K
N
V
F
V
I
G
A
T
N
R
P
E
Q
L
D
P
A
L
C
R
P
G
R
L
D
Q
L
I
Y
V
P
L
P
D
E
A
G
R
L
S
I
L
K
A
Q
L
R
K
T
P
V
S
K
D
V
D
L
A
Y
I
A
S
K
T
H
G
F
S
G
A
D
L
A
F
I
T
Q
R
A
V
K
L
A
-----------------------
I
K
E
S
-----------------------
I
----
A
A
E
I
EPVPE
L
T
K
R
H
F
E
E
A
M
R
D
A
R
R
S
V
S
D
V
E
I
R
R
Y
E
A
F
A
Q
Q
------
36
HHSearch
74.21
51%
-54
- C2 -
-
5FTJ
4
TERA_HUMAN
E:
[202-745]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
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S
E
S
N
L
R
K
A
F
E
E
A
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K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
--
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
---
Q
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
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R
F
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R
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V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
-----
D
D
V
D
----
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
---
K
M
D
L
---
I
D
L
E
D
E
T
I
D
AEV
M
N
S
L
---
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
R
E
T
V
-
V
E
V
P
Q
V
T
W
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G
G
L
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V
K
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L
Q
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L
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V
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L
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C
G
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L
L
A
K
A
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A
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C
Q
A
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I
S
I
K
G
P
E
L
L
T
M
W
F
G
E
S
E
A
N
V
R
E
I
F
D
K
A
R
Q
A
A
P
C
V
L
F
F
D
E
L
D
S
I
A
K
A
R
-
G
G
N
I
G
D
-
G
G
G
A
A
D
R
V
I
N
Q
I
L
T
E
M
D
G
M
S
T
K
K
N
V
F
I
I
G
A
T
N
R
P
D
I
I
D
P
A
I
L
R
P
G
R
L
D
Q
L
I
Y
I
P
L
P
D
E
K
S
R
V
A
I
L
K
A
N
L
R
K
S
P
V
A
K
D
V
D
L
E
F
L
A
K
M
T
N
G
F
S
G
A
D
L
T
E
I
C
Q
R
A
C
K
L
A
-----------------------
I
R
E
S
-----------------------
I
ESEI-
V
P
E
-----
I
R
R
D
H
F
E
E
A
M
R
F
A
R
R
----------------------
17
PsiBlast_PDB
72.49
47%
-61
- C2 -
-
5IFW
2
TERA_HUMAN
B:
[191-761]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
--------
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
R
---
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
-
K
L
----
A
D
D
V
D
----
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K----------
D
E
T
I
D
A
E
V
---
M
N
S
L
---
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
R
E
T
V
-
V
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V
P
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V
T
W
E
D
I
G
G
L
E
D
V
K
R
E
L
Q
E
L
V
Q
-----------------
K
G
V
L
F
Y
G
P
P
G
C
G
K
T
L
L
A
K
A
I
A
N
E
C
Q
A
N
F
I
S
I
K
G
P
E
L
L
T
M
W
F
G
E
S
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A
N
V
R
E
I
F
D
K
A
R
Q
A
A
P
C
V
L
F
F
D
E
L
D
S
I
A
K
---------------
D
R
V
I
N
Q
I
L
T
E
M
D
G
M
S
---
N
V
F
I
I
G
A
T
N
R
P
D
I
I
D
P
A
I
L
R
P
G
R
L
D
Q
L
I
Y
I
P
L
P
D
E
K
S
R
V
A
I
L
K
A
N
L
R
K
S
P
V
A
K
D
V
D
L
E
F
L
A
K
M
T
N
G
F
S
G
A
D
L
T
E
I
C
Q
R
A
C
K
L
A
IRESIESEIRRERERQTNPSAME
V
E
E
D
-----------------------
D
----
P
V
P
E
-----
I
R
R
D
H
F
E
E
A
M
R
F
A
R
R
S
V
S
D
N
D
I
R
K
Y
E
M
F
A
Q
-------
60
Fugue
72.24
34%
8
- C2 -
-
5E7P
5
?
B:
[18-744]
-----
P
L
S
H
L
R
L
T
A
R
L
N
T
S
A
L
D
S
-----------------------------------------
R
R
G
V
V
R
L
H
P
E
V
L
A
A
L
G
I
R
E
W
D
A
V
A
L
T
G
-
T
R
T
T
A
A
V
A
G
V
A
G
--
P
-
G
V
P
A
G
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A
L
L
D
D
V
T
L
S
N
A
G
V
R
E
N
A
A
V
L
V
S
P
V
T
--
V
Y
G
A
R
S
V
T
V
S
G
S
-----
R
L
-
A
T
Q
S
I
S
P
A
T
L
R
M
A
L
L
G
K
V
M
T
V
G
D
-----------------------------------------
T
V
S
L
L
P
R
D
S
A
A
T
S
A
L
A
S
S
V
-------------------------
G
I
T
W
T
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E
L
L
T
V
T
A
V
D
P
P
G
------------------------------------
T
V
S
V
Q
P
N
--------
S
V
V
S
W
G
P
P
T
G
R
-----------
H
T
V
S
P
Q
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V
S
F
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D
V
K
V
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L
L
K
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L
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V
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A
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V
R
A
V
C
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--
R
R
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L
D
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L
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L
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A
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G
-
G
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R
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L
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L
R
K
A
V
A
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G
-------
V
A
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N
V
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A
R
L
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S
L
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D
A
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A
R
R
S
L
L
E
M
L
L
R
G
V
P
S
------
E
D
L
D
----
L
G
D
I
A
D
H
T
P
G
F
V
V
A
D
L
A
A
V
V
R
E
G
A
L
R
A
A
A
R
---
A
S
S
S
---
D
D
D
P
V
---------
L
R
---
H
A
D
L
E
G
A
L
T
V
I
R
P
L
S
R
S
A
S
E
E
V
S
-
V
G
S
--
V
T
L
D
D
V
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M
V
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T
K
R
A
L
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V
L
W
P
L
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V
L
L
Y
G
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C
G
K
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R
A
L
A
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G
R
L
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V
H
A
V
K
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M
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K
W
V
G
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S
E
K
A
V
R
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L
F
A
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A
R
D
S
A
P
S
L
V
F
L
D
E
I
D
A
L
A
-----------
P
R
G
V
T
D
K
V
V
A
S
L
L
T
E
L
D
G
I
E
P
L
R
D
V
V
V
L
G
A
T
N
R
P
D
L
I
D
P
A
L
L
R
P
G
R
L
E
R
L
V
F
V
E
P
P
D
A
A
A
R
R
D
I
L
R
T
A
G
K
S
I
P
L
A
D
D
V
D
L
D
S
L
A
D
D
L
D
G
Y
S
A
A
D
C
V
A
L
L
R
E
S
A
M
T
A
-----------------------
M
R
R
S
-----------------------
I
----
D
A
A
D
-----
V
T
A
A
D
V
A
K
A
R
E
T
V
R
P
S
L
D
P
A
Q
V
E
S
L
R
E
F
A
E
K
------
1
PsiBlast_PDB
71.68
50%
-22
- C2 -
-
5VC7
3
VAT_THEAC
A:
[5-544]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
S
Y
E
D
I
G
G
L
S
E
Q
L
G
K
I
R
E
M
I
E
L
P
L
K
H
P
E
L
F
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R
L
G
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P
K
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V
I
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Y
G
P
P
G
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G
K
T
L
I
A
R
A
V
A
N
E
S
G
A
N
F
L
S
I
N
G
P
E
I
M
S
K
Y
Y
G
Q
S
E
Q
K
L
R
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I
F
S
K
A
E
E
T
A
P
S
I
I
F
I
D
E
I
D
S
I
A
P
K
R
E
E
V
Q
--
G
E
V
E
R
R
V
V
A
Q
L
L
T
L
M
D
G
M
K
---
E
R
G
H
V
I
V
I
G
A
T
N
R
I
D
A
I
D
P
A
L
R
R
P
G
R
F
D
R
E
I
E
I
G
V
P
D
R
N
G
R
K
E
I
L
M
I
H
T
R
N
M
P
L
G
----
M
S
E
E
E
KNKF
L
E
E
M
A
D
Y
T
Y
G
F
V
G
A
D
L
A
A
L
V
R
E
S
A
M
N
A
L
R
R
---
Y
L
P
E
IDL
D
K
P
I
P
T
E
I
L
---
E
K
M
V
----
V
T
E
D
D
F
K
N
A
L
K
S
I
E
P
S
S
L
R
E
V
M
-
V
E
V
P
N
V
H
W
D
D
I
G
G
L
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K
R
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K
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L
P
L
L
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V
F
K
R
L
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I
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K
G
F
L
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Y
G
P
P
G
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G
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L
L
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N
A
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F
I
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I
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G
P
E
V
L
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W
V
G
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K
A
I
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I
F
K
K
A
K
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V
A
P
A
I
V
F
L
D
E
I
D
S
I
A
P
R
R
-
G
T
T
S
-
D
-
S
G
-
V
T
E
R
I
V
N
Q
L
L
T
S
L
D
G
I
E
V
M
N
G
V
V
V
I
G
A
T
N
R
P
D
I
M
D
P
A
L
L
R
A
G
R
F
D
K
L
I
Y
I
P
P
P
D
K
E
A
R
L
S
I
L
K
V
H
T
K
N
M
P
L
A
P
D
V
D
L
N
D
I
A
Q
R
T
E
G
Y
V
G
A
D
L
E
N
L
C
R
E
A
G
M
N
A
-----------------------
Y
R
E
N
-----------------------
P
----
D
A
T
S
-----
V
S
Q
K
N
F
L
D
A
L
K
T
I
R
P
S
V
D
E
E
V
I
K
F
Y
R
T
L
S
E
-------
4
PsiBlast_PDB
71.44
50%
-24
- C2 -
-
5G4F
-
VAT_THEAC
A:
[186-725]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
S
Y
E
D
I
G
G
L
S
E
Q
L
G
K
I
R
E
M
I
E
L
P
L
K
H
P
E
L
F
E
R
L
G
I
T
P
P
K
G
V
I
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
S
G
A
N
F
L
S
I
N
G
P
E
I
M
S
K
Y
Y
G
Q
S
E
Q
K
L
R
E
I
F
S
K
A
E
E
T
A
P
S
I
I
F
I
D
E
I
D
S
I
A
P
K
R
E
E
V
Q
--
G
E
V
E
R
R
V
V
A
Q
L
L
T
L
M
D
G
M
K
---
E
R
G
H
V
I
V
I
G
A
T
N
R
I
D
A
I
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P
A
L
R
R
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G
R
F
D
R
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I
G
V
P
D
R
N
G
R
K
E
I
L
M
I
H
T
R
N
M
P
L
G
----
M
S
E
E
E
KNKF
L
E
E
M
A
D
Y
T
Y
G
F
V
G
A
D
L
A
A
L
V
R
E
S
A
M
N
A
L
R
R
---
Y
L
P
E
IDL
D
K
P
I
P
T
E
I
L
---
E
K
M
V
----
V
T
E
D
D
F
K
N
A
L
K
S
I
E
P
S
S
L
R
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V
M
-
V
E
V
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N
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H
W
D
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I
G
G
L
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V
K
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E
L
P
L
L
K
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D
V
F
K
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L
G
I
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K
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G
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L
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A
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F
I
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I
K
G
P
E
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L
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K
W
V
G
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A
I
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I
F
K
K
A
K
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V
A
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A
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F
L
D
E
I
D
S
I
A
P
R
R
-
G
T
T
S
-
D
-
S
G
-
V
T
E
R
I
V
N
Q
L
L
T
S
L
D
G
I
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V
M
N
G
V
V
V
I
G
A
T
N
R
P
D
I
M
D
P
A
L
L
R
A
G
R
F
D
K
L
I
Y
I
P
P
P
D
K
E
A
R
L
S
I
L
K
V
H
T
K
N
M
P
L
A
P
D
V
D
L
N
D
I
A
Q
R
T
E
G
Y
V
G
A
D
L
E
N
L
C
R
E
A
G
M
N
A
-----------------------
Y
R
E
N
-----------------------
P
----
D
A
T
S
-----
V
S
Q
K
N
F
L
D
A
L
K
T
I
R
P
S
V
D
E
E
V
I
K
F
Y
R
T
L
S
E
-------
18
PsiBlast_PDB
69.41
47%
-61
- C2 -
-
1R7R
1
TERA_MOUSE
A:
[190-735]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
V
G
G
C
R
K
Q
L
A
Q
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E
M
V
E
L
P
L
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H
P
A
L
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K
A
I
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V
K
P
P
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G
I
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L
Y
G
P
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G
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G
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I
A
R
A
V
A
N
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T
G
A
F
F
F
L
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G
P
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S
K
L
A
G
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S
N
L
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A
F
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A
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N
A
P
A
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I
F
I
D
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D
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A
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K
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H
--
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
-----
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
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D
I
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I
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D
A
T
G
R
L
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I
L
Q
I
H
T
K
N
M
-
K
L
----
A
D
D
V
D
----
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
KMD
L
I
D
L
---
E
D
E
T
I
D
A
E
V
---
M
N
S
L
---
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
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V
-
V
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L
A
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A
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A
N
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Q
A
N
F
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G
P
E
L
L
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M
W
F
G
E
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E
A
N
V
R
E
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F
D
K
A
R
Q
A
A
P
C
V
L
F
F
D
E
L
D
S
I
A
K
A
R
G
G
N
I
G
-
D
-
G
G
G
A
A
D
R
V
I
N
Q
I
L
T
E
M
D
------
N
V
F
I
I
G
A
T
N
R
P
D
I
I
D
P
A
I
L
R
P
G
R
L
D
Q
L
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Y
I
P
L
P
D
E
K
S
R
V
A
I
L
K
A
N
L
R
K
S
----
D
V
D
L
E
F
L
A
K
M
T
N
G
F
S
G
A
D
L
T
E
I
C
Q
R
A
C
K
L
A
IRES---------------------------------------------------
P
V
P
E
-----
I
R
R
D
H
--------------------------------
52
HHSearch
44.00
35%
-146
- C2 -
-
3D8B
2
FIGL1_HUMAN
A:
[78-339]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
P
V
N
W
E
D
I
A
G
V
E
F
A
K
A
T
I
K
E
I
V
V
W
P
M
L
R
P
D
I
F
T
G
L
R
-
G
P
P
K
G
I
L
L
F
G
P
P
G
T
G
K
T
L
I
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K
C
I
A
S
Q
S
G
A
T
F
F
S
I
S
A
S
S
L
T
S
K
W
V
G
E
G
E
K
M
V
R
A
L
F
A
V
A
R
C
Q
Q
P
A
V
I
F
I
D
E
I
D
S
L
L
S
Q
--------
E
S
S
R
R
I
K
T
E
F
L
V
Q
L
D
G
-----
S
E
D
R
I
L
V
V
G
A
T
N
R
P
Q
E
I
D
E
A
A
R
R
--
R
L
V
K
R
L
Y
I
P
L
P
E
A
S
A
R
K
Q
I
V
I
N
L
M
S
K
E
Q
C
C
----
L
S
E
E
E
----
I
E
Q
I
V
Q
Q
S
D
A
F
S
G
A
D
M
T
Q
L
C
R
E
A
S
L
G
P
I
R
S
---
L
Q
T
------------------
V
R
---
P
I
A
Y
I
D
F
E
N
A
F
R
T
V
R
P
S
V
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------